1. Introducció

Aquest arxiu conté les sol·lucions analítiques als problemes plantejats en la PAC1 Anàlisi de dades òmiques (M0-157). El projecte total del treball es pot consultar al: meu repositori github, cliqueu aquí

2. Carrega de dades

Abans que res, carreguem les dades al nostre entorn de treball. Treballarem amb un dels exemples de mostra, veure aquí. Aquest exemple porta dos arxius, DataInfo_S013 i DataValues_S013. Carreguem els dos fitxers:

DataInfo_S013 <- read.csv("DataInfo_S013.csv", sep = ",")
DataValues_S013 <- read.csv("DataValues_S013.csv", sep = ",")

Com és habitual amb dades òmiques, tenim moltes varibales i un nombre reduït de casos d’estudi. Tot i així, abans que res mirem l’estructura dels dos.

3. Eploració previa de les dades descarregades

dim(DataInfo_S013)
## [1] 695   4
dim(DataValues_S013)
## [1]  39 696

Aqui ja veiem que en l’arxiu Info hi ha 695 files que han de correspondre a les variables que hi ha a Values. En aquest darrer tenim 696 columnes i 39 files. Les files corresponen a cada cas d’estudi més les 695 columnes són les variables que es tenen de cada un d’ells.

Per veure què són les variables, mirem les 20 primeres files d’Info i podem fer-nos una idea.

head(DataInfo_S013,20)
##                    X           VarName    varTpe Description
## 1           SUBJECTS          SUBJECTS   integer    dataDesc
## 2            SURGERY           SURGERY character    dataDesc
## 3                AGE               AGE   integer    dataDesc
## 4             GENDER            GENDER character    dataDesc
## 5              Group             Group   integer    dataDesc
## 6           MEDDM_T0          MEDDM_T0   integer    dataDesc
## 7          MEDCOL_T0         MEDCOL_T0   integer    dataDesc
## 8          MEDINF_T0         MEDINF_T0   integer    dataDesc
## 9          MEDHTA_T0         MEDHTA_T0   integer    dataDesc
## 10            GLU_T0            GLU_T0   integer    dataDesc
## 11            INS_T0            INS_T0   numeric    dataDesc
## 12           HOMA_T0           HOMA_T0   numeric    dataDesc
## 13          HBA1C_T0          HBA1C_T0   numeric    dataDesc
## 14 HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0   numeric    dataDesc
## 15           PESO_T0           PESO_T0   integer    dataDesc
## 16            bmi_T0            bmi_T0   numeric    dataDesc
## 17             CC_T0             CC_T0   numeric    dataDesc
## 18           CINT_T0           CINT_T0   integer    dataDesc
## 19            CAD_T0            CAD_T0   integer    dataDesc
## 20            TAD_T0            TAD_T0   integer    dataDesc

Aqui ja veiem que hi ha 9 primers camps que semblen ser els que tenen la informació sobre el pacient de cada mostra. Mirem que contenen aquests camps a values:

# En mirem 10 en realitat, per comprovar que la primera columna és un index
head(DataValues_S013[,1:10])
##   X.1 SUBJECTS SURGERY AGE GENDER Group MEDDM_T0 MEDCOL_T0 MEDINF_T0 MEDHTA_T0
## 1   1        1 by pass  27      F     1        0         0         0         1
## 2   2        2 by pass  19      F     2        0         0         0         0
## 3   3        3 by pass  42      F     1        0         0         0         0
## 4   4        4 by pass  37      F     2        0         0         0         0
## 5   5        5 tubular  42      F     1        0         0         0         0
## 6   6        6 by pass  24      F     2        0         0         0         0

Com suposavem, aquestes columnes corresponen a: 1. Un codi de pacient (que està repetit a les dues primeres columnes, d’aquí que hi hagi una fila més a Info que columnes a Values) 2. La cirugia a la que va ser sotmés el pacient 3. L’edat i el gènere 4. Un grup de tractament 5. 4 tractaments que venen amb 0 i 1

Per veure que la resta són variables metabòliques, mirem 10 columnes més

head(DataValues_S013[,11:20],10)
##    GLU_T0 INS_T0 HOMA_T0 HBA1C_T0 HBA1C.mmol.mol_T0 PESO_T0 bmi_T0 CC_T0
## 1      85  11.40    2.40       NA                NA     151   62.9   0.7
## 2      78  12.10    2.32       NA                NA     139   47.0    NA
## 3      75   8.41    1.56      5.4             35.51      84   29.8   0.7
## 4      71  12.80    2.25      5.1             32.23     136   53.1   1.0
## 5      82   6.01    1.22      5.6             37.69     121   46.6   0.9
## 6      71   9.88    1.73      5.1             32.23     148   48.8   0.7
## 7      80   9.20    1.82      5.6             37.69     109   43.7   0.9
## 8      90   3.40    0.76      5.5             36.60     109   41.8   0.9
## 9      92   5.43    1.23      5.7             38.78     114   44.0   0.9
## 10     84   6.98    1.45      5.5             36.60     120   40.6    NA
##    CINT_T0 CAD_T0
## 1      116    167
## 2       NA     NA
## 3       90    126
## 4      157    162
## 5      123    132
## 6      110    148
## 7      122    141
## 8      124    136
## 9      136    148
## 10      NA     NA

Obviament ja ho veiem i també podem veure que hi ha més d’un valor que no es té per a alguna de les variables (NA). Anem a veure si n’hi ha molts

sum(is.na(DataValues_S013))/(dim(DataValues_S013)[1]*dim(DataValues_S013)[2])
## [1] 0.1248895

Això apunta a que tenim un 12,5% de valors desconeguts. Aquest és un aspecte que caldrà tenir en compte en els anàlisi posteriors

4. Generació de l’obsject SummarizedExperiment

Ara que ja sabem que tenim a les dades, podem procedir a carregar-les en un objecte SummarizedExperiment. Per a fer-ho, convertirem però les dades a un data frame i li traurem la primera columna que ja hem vist que és redundant amb la segona. Aleshores ja ho podem carregar. En concret, carregarem:

  1. Les dades de les 9 primeres columnes (obviant la primera que esta duplicada) de DataVAlues corresponen a dades dels pacients que els guardarem com a rowData ja que no formen part de l’anàlisi dels metabolits
  2. La resta de dades de DataValues seràn els assays que és on es guarden les dades de les mostres que tenim
  3. L’arxiu DataInfo com a colData que és on es guarda la informació de com és cada columna d’assays. D’aquí només hem d’agafar la part corresponent als metabolits. És a dir de la fila 11 endavant.
# Primer carreguem la llibreria per poder tractar el SummarizedExperiment
library(SummarizedExperiment)
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
## 
## Attaching package: 'MatrixGenerics'
## The following objects are masked from 'package:matrixStats':
## 
##     colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse,
##     colCounts, colCummaxs, colCummins, colCumprods, colCumsums,
##     colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs,
##     colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
##     colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds,
##     colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads,
##     colWeightedMeans, colWeightedMedians, colWeightedSds,
##     colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet,
##     rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods,
##     rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps,
##     rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins,
##     rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks,
##     rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars,
##     rowWeightedMads, rowWeightedMeans, rowWeightedMedians,
##     rowWeightedSds, rowWeightedVars
## Loading required package: GenomicRanges
## Loading required package: stats4
## Loading required package: BiocGenerics
## 
## Attaching package: 'BiocGenerics'
## The following objects are masked from 'package:stats':
## 
##     IQR, mad, sd, var, xtabs
## The following objects are masked from 'package:base':
## 
##     anyDuplicated, aperm, append, as.data.frame, basename, cbind,
##     colnames, dirname, do.call, duplicated, eval, evalq, Filter, Find,
##     get, grep, grepl, intersect, is.unsorted, lapply, Map, mapply,
##     match, mget, order, paste, pmax, pmax.int, pmin, pmin.int,
##     Position, rank, rbind, Reduce, rownames, sapply, saveRDS, setdiff,
##     table, tapply, union, unique, unsplit, which.max, which.min
## Loading required package: S4Vectors
## 
## Attaching package: 'S4Vectors'
## The following object is masked from 'package:utils':
## 
##     findMatches
## The following objects are masked from 'package:base':
## 
##     expand.grid, I, unname
## Loading required package: IRanges
## 
## Attaching package: 'IRanges'
## The following object is masked from 'package:grDevices':
## 
##     windows
## Loading required package: GenomeInfoDb
## Loading required package: Biobase
## Welcome to Bioconductor
## 
##     Vignettes contain introductory material; view with
##     'browseVignettes()'. To cite Bioconductor, see
##     'citation("Biobase")', and for packages 'citation("pkgname")'.
## 
## Attaching package: 'Biobase'
## The following object is masked from 'package:MatrixGenerics':
## 
##     rowMedians
## The following objects are masked from 'package:matrixStats':
## 
##     anyMissing, rowMedians
# Després generem les dades de pacients i de metabolits i la llista de rownames que volem tal i com hem indicat al text
pacients <- DataValues_S013[,2:10]
metabolits <- DataValues_S013[,11:696]
colNames <- DataInfo_S013[10:695,]
# Ara ja podem carregar el SummarizedExperiment
seMA <- SummarizedExperiment(assays = list(counts = as.matrix(metabolits)),
                             colData = colNames,
                             rowData = pacients)
seMA
## class: SummarizedExperiment 
## dim: 39 686 
## metadata(0):
## assays(1): counts
## rownames: NULL
## rowData names(9): SUBJECTS SURGERY ... MEDINF_T0 MEDHTA_T0
## colnames(686): GLU_T0 INS_T0 ... SM.C24.0_T5 SM.C24.1_T5
## colData names(4): X VarName varTpe Description

Sembla que l’objecte s’ha generat correctament

Mirem un parell de funcions que es poden fer.

# Comprovem com es diuen les columnes que tenim en cada una de les classes de dins de l'objecte
dimnames(seMA)
## [[1]]
## NULL
## 
## [[2]]
##   [1] "GLU_T0"            "INS_T0"            "HOMA_T0"          
##   [4] "HBA1C_T0"          "HBA1C.mmol.mol_T0" "PESO_T0"          
##   [7] "bmi_T0"            "CC_T0"             "CINT_T0"          
##  [10] "CAD_T0"            "TAD_T0"            "TAS_T0"           
##  [13] "TG_T0"             "COL_T0"            "LDL_T0"           
##  [16] "HDL_T0"            "VLDL_T0"           "PCR_T0"           
##  [19] "LEP_T0"            "ADIPO_T0"          "GOT_T0"           
##  [22] "GPT_T0"            "GGT_T0"            "URICO_T0"         
##  [25] "CREAT_T0"          "UREA_T0"           "HIERRO_T0"        
##  [28] "TRANSF_T0"         "FERR_T0"           "Ile_T0"           
##  [31] "Leu_T0"            "Val_T0"            "Ala_T0"           
##  [34] "Pro_T0"            "Gly_T0"            "Ser_T0"           
##  [37] "Trp_T0"            "Phe_T0"            "Met_T0"           
##  [40] "Orn_T0"            "Arg_T0"            "His_T0"           
##  [43] "Asn_T0"            "Asp_T0"            "Glu_T0"           
##  [46] "Gln_T0"            "Cit_T0"            "Tyr_T0"           
##  [49] "Thr_T0"            "Lys_T0"            "Creatinine_T0"    
##  [52] "Kynurenine_T0"     "Putrescine_T0"     "Sarcosine_T0"     
##  [55] "Serotonin_T0"      "Taurine_T0"        "SDMA_T0"          
##  [58] "C0_T0"             "C2_T0"             "C3.OH_T0"         
##  [61] "C6..C4.1.DC._T0"   "C5.DC..C6.OH._T0"  "C7.DC_T0"         
##  [64] "C8_T0"             "C10_T0"            "C10.1_T0"         
##  [67] "C10.2_T0"          "C14.1_T0"          "C14.2_T0"         
##  [70] "C16.1_T0"          "C16.2_T0"          "C16.2.OH_T0"      
##  [73] "C18.1_T0"          "C18.1.OH_T0"       "C18.2_T0"         
##  [76] "lysoPC.a.C16.0_T0" "lysoPC.a.C16.1_T0" "lysoPC.a.C17.0_T0"
##  [79] "lysoPC.a.C18.0_T0" "lysoPC.a.C18.1_T0" "lysoPC.a.C18.2_T0"
##  [82] "lysoPC.a.C20.3_T0" "lysoPC.a.C20.4_T0" "lysoPC.a.C24.0_T0"
##  [85] "lysoPC.a.C26.0_T0" "lysoPC.a.C26.1_T0" "lysoPC.a.C28.0_T0"
##  [88] "lysoPC.a.C28.1_T0" "PC.aa.C24.0_T0"    "PC.aa.C28.1_T0"   
##  [91] "PC.aa.C30.0_T0"    "PC.aa.C32.0_T0"    "PC.aa.C32.1_T0"   
##  [94] "PC.aa.C32.3_T0"    "PC.aa.C34.1_T0"    "PC.aa.C34.2_T0"   
##  [97] "PC.aa.C34.3_T0"    "PC.aa.C34.4_T0"    "PC.aa.C36.0_T0"   
## [100] "PC.aa.C36.1_T0"    "PC.aa.C36.2_T0"    "PC.aa.C36.3_T0"   
## [103] "PC.aa.C36.4_T0"    "PC.aa.C36.5_T0"    "PC.aa.C38.0_T0"   
## [106] "PC.aa.C38.1_T0"    "PC.aa.C38.3_T0"    "PC.aa.C38.4_T0"   
## [109] "PC.aa.C38.5_T0"    "PC.aa.C38.6_T0"    "PC.aa.C40.1_T0"   
## [112] "PC.aa.C40.2_T0"    "PC.aa.C40.3_T0"    "PC.aa.C40.4_T0"   
## [115] "PC.aa.C40.5_T0"    "PC.aa.C40.6_T0"    "PC.aa.C42.0_T0"   
## [118] "PC.aa.C42.1_T0"    "PC.aa.C42.2_T0"    "PC.aa.C42.4_T0"   
## [121] "PC.aa.C42.5_T0"    "PC.aa.C42.6_T0"    "PC.ae.C30.0_T0"   
## [124] "PC.ae.C32.1_T0"    "PC.ae.C32.2_T0"    "PC.ae.C34.0_T0"   
## [127] "PC.ae.C34.1_T0"    "PC.ae.C34.2_T0"    "PC.ae.C34.3_T0"   
## [130] "PC.ae.C36.0_T0"    "PC.ae.C36.1_T0"    "PC.ae.C36.2_T0"   
## [133] "PC.ae.C36.3_T0"    "PC.ae.C36.4_T0"    "PC.ae.C36.5_T0"   
## [136] "PC.ae.C38.0_T0"    "PC.ae.C38.2_T0"    "PC.ae.C38.3_T0"   
## [139] "PC.ae.C38.4_T0"    "PC.ae.C38.5_T0"    "PC.ae.C38.6_T0"   
## [142] "PC.ae.C40.1_T0"    "PC.ae.C40.2_T0"    "PC.ae.C40.3_T0"   
## [145] "PC.ae.C40.4_T0"    "PC.ae.C40.5_T0"    "PC.ae.C40.6_T0"   
## [148] "PC.ae.C42.1_T0"    "PC.ae.C42.2_T0"    "PC.ae.C42.3_T0"   
## [151] "PC.ae.C42.4_T0"    "PC.ae.C42.5_T0"    "PC.ae.C44.3_T0"   
## [154] "PC.ae.C44.4_T0"    "PC.ae.C44.5_T0"    "PC.ae.C44.6_T0"   
## [157] "SM..OH..C14.1_T0"  "SM..OH..C16.1_T0"  "SM..OH..C22.1_T0" 
## [160] "SM..OH..C22.2_T0"  "SM..OH..C24.1_T0"  "SM.C16.0_T0"      
## [163] "SM.C16.1_T0"       "SM.C18.0_T0"       "SM.C18.1_T0"      
## [166] "SM.C20.2_T0"       "SM.C24.0_T0"       "SM.C24.1_T0"      
## [169] "MEDDM_T2"          "MEDCOL_T2"         "MEDINF_T2"        
## [172] "MEDHTA_T2"         "GLU_T2"            "INS_T2"           
## [175] "HOMA_T2"           "HBA1C_T2"          "HBA1C.mmol.mol_T2"
## [178] "PESO_T2"           "bmi_T2"            "CC_T2"            
## [181] "CINT_T2"           "CAD_T2"            "TAD_T2"           
## [184] "TAS_T2"            "TG_T2"             "COL_T2"           
## [187] "LDL_T2"            "HDL_T2"            "VLDL_T2"          
## [190] "PCR_T2"            "LEP_T2"            "ADIPO_T2"         
## [193] "GOT_T2"            "GPT_T2"            "GGT_T2"           
## [196] "URICO_T2"          "CREAT_T2"          "UREA_T2"          
## [199] "HIERRO_T2"         "TRANSF_T2"         "FERR_T2"          
## [202] "Ile_T2"            "Leu_T2"            "Val_T2"           
## [205] "Ala_T2"            "Pro_T2"            "Gly_T2"           
## [208] "Ser_T2"            "Trp_T2"            "Phe_T2"           
## [211] "Met_T2"            "Orn_T2"            "Arg_T2"           
## [214] "His_T2"            "Asn_T2"            "Asp_T2"           
## [217] "Glu_T2"            "Gln_T2"            "Cit_T2"           
## [220] "Tyr_T2"            "Thr_T2"            "Lys_T2"           
## [223] "Creatinine_T2"     "Kynurenine_T2"     "Putrescine_T2"    
## [226] "Sarcosine_T2"      "Serotonin_T2"      "Taurine_T2"       
## [229] "SDMA_T2"           "C0_T2"             "C2_T2"            
## [232] "C3.OH_T2"          "C6..C4.1.DC._T2"   "C5.DC..C6.OH._T2" 
## [235] "C7.DC_T2"          "C8_T2"             "C10_T2"           
## [238] "C10.1_T2"          "C10.2_T2"          "C14.1_T2"         
## [241] "C14.2_T2"          "C16.1_T2"          "C16.2_T2"         
## [244] "C16.2.OH_T2"       "C18.1_T2"          "C18.1.OH_T2"      
## [247] "C18.2_T2"          "X"                 "lysoPC.a.C14.0_T2"
## [250] "lysoPC.a.C16.0_T2" "lysoPC.a.C16.1_T2" "lysoPC.a.C17.0_T2"
## [253] "lysoPC.a.C18.0_T2" "lysoPC.a.C18.1_T2" "lysoPC.a.C18.2_T2"
## [256] "lysoPC.a.C20.3_T2" "lysoPC.a.C20.4_T2" "lysoPC.a.C24.0_T2"
## [259] "lysoPC.a.C26.0_T2" "lysoPC.a.C26.1_T2" "lysoPC.a.C28.0_T2"
## [262] "lysoPC.a.C28.1_T2" "PC.aa.C24.0_T2"    "PC.aa.C28.1_T2"   
## [265] "PC.aa.C30.0_T2"    "PC.aa.C32.0_T2"    "PC.aa.C32.1_T2"   
## [268] "PC.aa.C32.3_T2"    "PC.aa.C34.1_T2"    "PC.aa.C34.2_T2"   
## [271] "PC.aa.C34.3_T2"    "PC.aa.C34.4_T2"    "PC.aa.C36.0_T2"   
## [274] "PC.aa.C36.1_T2"    "PC.aa.C36.2_T2"    "PC.aa.C36.3_T2"   
## [277] "PC.aa.C36.4_T2"    "PC.aa.C36.5_T2"    "PC.aa.C38.0_T2"   
## [280] "PC.aa.C38.1_T2"    "PC.aa.C38.3_T2"    "PC.aa.C38.4_T2"   
## [283] "PC.aa.C38.5_T2"    "PC.aa.C38.6_T2"    "PC.aa.C40.1_T2"   
## [286] "PC.aa.C40.2_T2"    "PC.aa.C40.3_T2"    "PC.aa.C40.4_T2"   
## [289] "PC.aa.C40.5_T2"    "PC.aa.C40.6_T2"    "PC.aa.C42.0_T2"   
## [292] "PC.aa.C42.1_T2"    "PC.aa.C42.2_T2"    "PC.aa.C42.4_T2"   
## [295] "PC.aa.C42.5_T2"    "PC.aa.C42.6_T2"    "PC.ae.C30.0_T2"   
## [298] "PC.ae.C32.1_T2"    "PC.ae.C32.2_T2"    "PC.ae.C34.0_T2"   
## [301] "PC.ae.C34.1_T2"    "PC.ae.C34.2_T2"    "PC.ae.C34.3_T2"   
## [304] "PC.ae.C36.0_T2"    "PC.ae.C36.1_T2"    "PC.ae.C36.2_T2"   
## [307] "PC.ae.C36.3_T2"    "PC.ae.C36.4_T2"    "PC.ae.C36.5_T2"   
## [310] "PC.ae.C38.0_T2"    "PC.ae.C38.2_T2"    "PC.ae.C38.3_T2"   
## [313] "PC.ae.C38.4_T2"    "PC.ae.C38.5_T2"    "PC.ae.C38.6_T2"   
## [316] "PC.ae.C40.1_T2"    "PC.ae.C40.2_T2"    "PC.ae.C40.3_T2"   
## [319] "PC.ae.C40.4_T2"    "PC.ae.C40.5_T2"    "PC.ae.C40.6_T2"   
## [322] "PC.ae.C42.1_T2"    "PC.ae.C42.2_T2"    "PC.ae.C42.3_T2"   
## [325] "PC.ae.C42.4_T2"    "PC.ae.C42.5_T2"    "PC.ae.C44.3_T2"   
## [328] "PC.ae.C44.4_T2"    "PC.ae.C44.5_T2"    "PC.ae.C44.6_T2"   
## [331] "SM..OH..C14.1_T2"  "SM..OH..C16.1_T2"  "SM..OH..C22.1_T2" 
## [334] "SM..OH..C22.2_T2"  "SM..OH..C24.1_T2"  "SM.C16.0_T2"      
## [337] "SM.C16.1_T2"       "SM.C18.0_T2"       "SM.C18.1_T2"      
## [340] "SM.C20.2_T2"       "SM.C24.0_T2"       "SM.C24.1_T2"      
## [343] "MEDDM_T4"          "MEDCOL_T4"         "MEDINF_T4"        
## [346] "MEDHTA_T4"         "GLU_T4"            "INS_T4"           
## [349] "HOMA_T4"           "HBA1C_T4"          "HBA1C.mmol.mol_T4"
## [352] "PESO_T4"           "bmi_T4"            "CC_T4"            
## [355] "CINT_T4"           "CAD_T4"            "TAD_T4"           
## [358] "TAS_T4"            "TG_T4"             "COL_T4"           
## [361] "LDL_T4"            "HDL_T4"            "VLDL_T4"          
## [364] "PCR_T4"            "LEP_T4"            "ADIPO_T4"         
## [367] "GOT_T4"            "GPT_T4"            "GGT_T4"           
## [370] "URICO_T4"          "CREAT_T4"          "UREA_T4"          
## [373] "HIERRO_T4"         "TRANSF_T4"         "FERR_T4"          
## [376] "Ile_T4"            "Leu_T4"            "Val_T4"           
## [379] "Ala_T4"            "Pro_T4"            "Gly_T4"           
## [382] "Ser_T4"            "Trp_T4"            "Phe_T4"           
## [385] "Met_T4"            "Orn_T4"            "Arg_T4"           
## [388] "His_T4"            "Asn_T4"            "Asp_T4"           
## [391] "Glu_T4"            "Gln_T4"            "Cit_T4"           
## [394] "Tyr_T4"            "Thr_T4"            "Lys_T4"           
## [397] "Creatinine_T4"     "Kynurenine_T4"     "Putrescine_T4"    
## [400] "Sarcosine_T4"      "Serotonin_T4"      "Taurine_T4"       
## [403] "SDMA_T4"           "C0_T4"             "C2_T4"            
## [406] "C3.OH_T4"          "C6..C4.1.DC._T4"   "C5.DC..C6.OH._T4" 
## [409] "C7.DC_T4"          "C8_T4"             "C10_T4"           
## [412] "C10.1_T4"          "C10.2_T4"          "C14.1_T4"         
## [415] "C14.2_T4"          "C16.1_T4"          "C16.2_T4"         
## [418] "C16.2.OH_T4"       "C18.1_T4"          "C18.1.OH_T4"      
## [421] "C18.2_T4"          "lysoPC.a.C16.0_T4" "lysoPC.a.C16.1_T4"
## [424] "lysoPC.a.C17.0_T4" "lysoPC.a.C18.0_T4" "lysoPC.a.C18.1_T4"
## [427] "lysoPC.a.C18.2_T4" "lysoPC.a.C20.3_T4" "lysoPC.a.C20.4_T4"
## [430] "lysoPC.a.C24.0_T4" "lysoPC.a.C26.0_T4" "lysoPC.a.C26.1_T4"
## [433] "lysoPC.a.C28.0_T4" "lysoPC.a.C28.1_T4" "PC.aa.C24.0_T4"   
## [436] "PC.aa.C28.1_T4"    "PC.aa.C30.0_T4"    "PC.aa.C32.0_T4"   
## [439] "PC.aa.C32.1_T4"    "PC.aa.C32.3_T4"    "PC.aa.C34.1_T4"   
## [442] "PC.aa.C34.2_T4"    "PC.aa.C34.3_T4"    "PC.aa.C34.4_T4"   
## [445] "PC.aa.C36.0_T4"    "PC.aa.C36.1_T4"    "PC.aa.C36.2_T4"   
## [448] "PC.aa.C36.3_T4"    "PC.aa.C36.4_T4"    "PC.aa.C36.5_T4"   
## [451] "PC.aa.C38.0_T4"    "PC.aa.C38.1_T4"    "PC.aa.C38.3_T4"   
## [454] "PC.aa.C38.4_T4"    "PC.aa.C38.5_T4"    "PC.aa.C38.6_T4"   
## [457] "PC.aa.C40.1_T4"    "PC.aa.C40.2_T4"    "PC.aa.C40.3_T4"   
## [460] "PC.aa.C40.4_T4"    "PC.aa.C40.5_T4"    "PC.aa.C40.6_T4"   
## [463] "PC.aa.C42.0_T4"    "PC.aa.C42.1_T4"    "PC.aa.C42.2_T4"   
## [466] "PC.aa.C42.4_T4"    "PC.aa.C42.5_T4"    "PC.aa.C42.6_T4"   
## [469] "PC.ae.C30.0_T4"    "PC.ae.C32.1_T4"    "PC.ae.C32.2_T4"   
## [472] "PC.ae.C34.0_T4"    "PC.ae.C34.1_T4"    "PC.ae.C34.2_T4"   
## [475] "PC.ae.C34.3_T4"    "PC.ae.C36.0_T4"    "PC.ae.C36.1_T4"   
## [478] "PC.ae.C36.2_T4"    "PC.ae.C36.3_T4"    "PC.ae.C36.4_T4"   
## [481] "PC.ae.C36.5_T4"    "PC.ae.C38.0_T4"    "PC.ae.C38.2_T4"   
## [484] "PC.ae.C38.3_T4"    "PC.ae.C38.4_T4"    "PC.ae.C38.5_T4"   
## [487] "PC.ae.C38.6_T4"    "PC.ae.C40.1_T4"    "PC.ae.C40.2_T4"   
## [490] "PC.ae.C40.3_T4"    "PC.ae.C40.4_T4"    "PC.ae.C40.5_T4"   
## [493] "PC.ae.C40.6_T4"    "PC.ae.C42.1_T4"    "PC.ae.C42.2_T4"   
## [496] "PC.ae.C42.3_T4"    "PC.ae.C42.4_T4"    "PC.ae.C42.5_T4"   
## [499] "PC.ae.C44.3_T4"    "PC.ae.C44.4_T4"    "PC.ae.C44.5_T4"   
## [502] "PC.ae.C44.6_T4"    "SM..OH..C14.1_T4"  "SM..OH..C16.1_T4" 
## [505] "SM..OH..C22.1_T4"  "SM..OH..C22.2_T4"  "SM..OH..C24.1_T4" 
## [508] "SM.C16.0_T4"       "SM.C16.1_T4"       "SM.C18.0_T4"      
## [511] "SM.C18.1_T4"       "SM.C20.2_T4"       "SM.C24.0_T4"      
## [514] "SM.C24.1_T4"       "MEDDM_T5"          "MEDCOL_T5"        
## [517] "MEDINF_T5"         "MEDHTA_T5"         "GLU_T5"           
## [520] "INS_T5"            "HOMA_T5"           "HBA1C_T5"         
## [523] "HBA1C.mmol.mol_T5" "PESO_T5"           "bmi_T5"           
## [526] "CC_T5"             "CINT_T5"           "CAD_T5"           
## [529] "TAD_T5"            "TAS_T5"            "TG_T5"            
## [532] "COL_T5"            "LDL_T5"            "HDL_T5"           
## [535] "VLDL_T5"           "PCR_T5"            "LEP_T5"           
## [538] "ADIPO_T5"          "GOT_T5"            "GPT_T5"           
## [541] "GGT_T5"            "URICO_T5"          "CREAT_T5"         
## [544] "UREA_T5"           "HIERRO_T5"         "TRANSF_T5"        
## [547] "FERR_T5"           "Ile_T5"            "Leu_T5"           
## [550] "Val_T5"            "Ala_T5"            "Pro_T5"           
## [553] "Gly_T5"            "Ser_T5"            "Trp_T5"           
## [556] "Phe_T5"            "Met_T5"            "Orn_T5"           
## [559] "Arg_T5"            "His_T5"            "Asn_T5"           
## [562] "Asp_T5"            "Glu_T5"            "Gln_T5"           
## [565] "Cit_T5"            "Tyr_T5"            "Thr_T5"           
## [568] "Lys_T5"            "Creatinine_T5"     "Kynurenine_T5"    
## [571] "Putrescine_T5"     "Sarcosine_T5"      "Serotonin_T5"     
## [574] "Taurine_T5"        "SDMA_T5"           "C0_T5"            
## [577] "C2_T5"             "C3.OH_T5"          "C6..C4.1.DC._T5"  
## [580] "C5.DC..C6.OH._T5"  "C7.DC_T5"          "C8_T5"            
## [583] "C10_T5"            "C10.1_T5"          "C10.2_T5"         
## [586] "C14.1_T5"          "C14.2_T5"          "C16.1_T5"         
## [589] "C16.2_T5"          "C16.2.OH_T5"       "C18.1_T5"         
## [592] "C18.1.OH_T5"       "C18.2_T5"          "lysoPC.a.C16.0_T5"
## [595] "lysoPC.a.C16.1_T5" "lysoPC.a.C17.0_T5" "lysoPC.a.C18.0_T5"
## [598] "lysoPC.a.C18.1_T5" "lysoPC.a.C18.2_T5" "lysoPC.a.C20.3_T5"
## [601] "lysoPC.a.C20.4_T5" "lysoPC.a.C24.0_T5" "lysoPC.a.C26.0_T5"
## [604] "lysoPC.a.C26.1_T5" "lysoPC.a.C28.0_T5" "lysoPC.a.C28.1_T5"
## [607] "PC.aa.C24.0_T5"    "PC.aa.C28.1_T5"    "PC.aa.C30.0_T5"   
## [610] "PC.aa.C32.0_T5"    "PC.aa.C32.1_T5"    "PC.aa.C32.3_T5"   
## [613] "PC.aa.C34.1_T5"    "PC.aa.C34.2_T5"    "PC.aa.C34.3_T5"   
## [616] "PC.aa.C34.4_T5"    "PC.aa.C36.0_T5"    "PC.aa.C36.1_T5"   
## [619] "PC.aa.C36.2_T5"    "PC.aa.C36.3_T5"    "PC.aa.C36.4_T5"   
## [622] "PC.aa.C36.5_T5"    "PC.aa.C38.0_T5"    "PC.aa.C38.1_T5"   
## [625] "PC.aa.C38.3_T5"    "PC.aa.C38.4_T5"    "PC.aa.C38.5_T5"   
## [628] "PC.aa.C38.6_T5"    "PC.aa.C40.1_T5"    "PC.aa.C40.2_T5"   
## [631] "PC.aa.C40.3_T5"    "PC.aa.C40.4_T5"    "PC.aa.C40.5_T5"   
## [634] "PC.aa.C40.6_T5"    "PC.aa.C42.0_T5"    "PC.aa.C42.1_T5"   
## [637] "PC.aa.C42.2_T5"    "PC.aa.C42.4_T5"    "PC.aa.C42.5_T5"   
## [640] "PC.aa.C42.6_T5"    "PC.ae.C30.0_T5"    "PC.ae.C32.1_T5"   
## [643] "PC.ae.C32.2_T5"    "PC.ae.C34.0_T5"    "PC.ae.C34.1_T5"   
## [646] "PC.ae.C34.2_T5"    "PC.ae.C34.3_T5"    "PC.ae.C36.0_T5"   
## [649] "PC.ae.C36.1_T5"    "PC.ae.C36.2_T5"    "PC.ae.C36.3_T5"   
## [652] "PC.ae.C36.4_T5"    "PC.ae.C36.5_T5"    "PC.ae.C38.0_T5"   
## [655] "PC.ae.C38.2_T5"    "PC.ae.C38.3_T5"    "PC.ae.C38.4_T5"   
## [658] "PC.ae.C38.5_T5"    "PC.ae.C38.6_T5"    "PC.ae.C40.1_T5"   
## [661] "PC.ae.C40.2_T5"    "PC.ae.C40.3_T5"    "PC.ae.C40.4_T5"   
## [664] "PC.ae.C40.5_T5"    "PC.ae.C40.6_T5"    "PC.ae.C42.1_T5"   
## [667] "PC.ae.C42.2_T5"    "PC.ae.C42.3_T5"    "PC.ae.C42.4_T5"   
## [670] "PC.ae.C42.5_T5"    "PC.ae.C44.3_T5"    "PC.ae.C44.4_T5"   
## [673] "PC.ae.C44.5_T5"    "PC.ae.C44.6_T5"    "SM..OH..C14.1_T5" 
## [676] "SM..OH..C16.1_T5"  "SM..OH..C22.1_T5"  "SM..OH..C22.2_T5" 
## [679] "SM..OH..C24.1_T5"  "SM.C16.0_T5"       "SM.C16.1_T5"      
## [682] "SM.C18.0_T5"       "SM.C18.1_T5"       "SM.C20.2_T5"      
## [685] "SM.C24.0_T5"       "SM.C24.1_T5"
# I ara mirem les 10 primeres columnes i les 5 primeres files d'assays
assay(seMA)[1:5, 1:10]
##      GLU_T0 INS_T0 HOMA_T0 HBA1C_T0 HBA1C.mmol.mol_T0 PESO_T0 bmi_T0 CC_T0
## [1,]     85  11.40    2.40       NA                NA     151   62.9   0.7
## [2,]     78  12.10    2.32       NA                NA     139   47.0    NA
## [3,]     75   8.41    1.56      5.4             35.51      84   29.8   0.7
## [4,]     71  12.80    2.25      5.1             32.23     136   53.1   1.0
## [5,]     82   6.01    1.22      5.6             37.69     121   46.6   0.9
##      CINT_T0 CAD_T0
## [1,]     116    167
## [2,]      NA     NA
## [3,]      90    126
## [4,]     157    162
## [5,]     123    132
# I també mirem com ha quedat colData
colData(seMA)
## DataFrame with 686 rows and 4 columns
##                                   X           VarName      varTpe Description
##                         <character>       <character> <character> <character>
## GLU_T0                       GLU_T0            GLU_T0     integer    dataDesc
## INS_T0                       INS_T0            INS_T0     numeric    dataDesc
## HOMA_T0                     HOMA_T0           HOMA_T0     numeric    dataDesc
## HBA1C_T0                   HBA1C_T0          HBA1C_T0     numeric    dataDesc
## HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0     numeric    dataDesc
## ...                             ...               ...         ...         ...
## SM.C18.0_T5             SM.C18.0_T5       SM.C18.0_T5     numeric    dataDesc
## SM.C18.1_T5             SM.C18.1_T5       SM.C18.1_T5     numeric    dataDesc
## SM.C20.2_T5             SM.C20.2_T5       SM.C20.2_T5     numeric    dataDesc
## SM.C24.0_T5             SM.C24.0_T5       SM.C24.0_T5     numeric    dataDesc
## SM.C24.1_T5             SM.C24.1_T5       SM.C24.1_T5     numeric    dataDesc
# I les dades bàsiques dels pacients
rowData(seMA)
## DataFrame with 39 rows and 9 columns
##      SUBJECTS     SURGERY       AGE      GENDER     Group  MEDDM_T0 MEDCOL_T0
##     <integer> <character> <integer> <character> <integer> <integer> <integer>
## 1           1     by pass        27           F         1         0         0
## 2           2     by pass        19           F         2         0         0
## 3           3     by pass        42           F         1         0         0
## 4           4     by pass        37           F         2         0         0
## 5           5     tubular        42           F         1         0         0
## ...       ...         ...       ...         ...       ...       ...       ...
## 35         35     tubular        39           M         2         0         0
## 36         36     tubular        35           M         1         0         0
## 37         37     by pass        46           M         2         0         0
## 38         38     tubular        41           M         1         0         0
## 39         39     by pass        26           M         1         0         0
##     MEDINF_T0 MEDHTA_T0
##     <integer> <integer>
## 1           0         1
## 2           0         0
## 3           0         0
## 4           0         0
## 5           0         0
## ...       ...       ...
## 35          0         1
## 36          0         0
## 37          1         0
## 38          0         0
## 39          0         0

5. Anàlisi exploratoria inicial de les dades

5.1. Descripció de les dades

Fins ara hem vist que les nostres dades tenen NA, el que pot suposar un problema. Anem a veure també si la variabilitat de rangs és molt gran´i ens cal normalitzar les dades. Fem un summary a més per veure com varien els estadístics bàsics. Si ho fem amb tot l’arxiu no s’arriba a apreciar la sortida, així que en fem uns quants

summary(assay(seMA)[,1:150])
##      GLU_T0          INS_T0         HOMA_T0          HBA1C_T0    
##  Min.   : 71.0   Min.   : 3.40   Min.   : 0.760   Min.   :5.100  
##  1st Qu.: 91.0   1st Qu.:11.85   1st Qu.: 2.435   1st Qu.:5.400  
##  Median :103.0   Median :16.00   Median : 4.210   Median :5.600  
##  Mean   :106.5   Mean   :17.60   Mean   : 4.890   Mean   :5.592  
##  3rd Qu.:109.5   3rd Qu.:21.15   3rd Qu.: 5.720   3rd Qu.:5.800  
##  Max.   :263.0   Max.   :43.00   Max.   :13.600   Max.   :6.400  
##                                                   NA's   :15     
##  HBA1C.mmol.mol_T0    PESO_T0          bmi_T0          CC_T0       
##  Min.   :32.23     Min.   : 84.0   Min.   :29.80   Min.   :0.7000  
##  1st Qu.:35.51     1st Qu.:119.5   1st Qu.:44.40   1st Qu.:0.9000  
##  Median :37.69     Median :135.0   Median :48.80   Median :0.9000  
##  Mean   :37.60     Mean   :140.0   Mean   :50.52   Mean   :0.9343  
##  3rd Qu.:39.88     3rd Qu.:155.0   3rd Qu.:55.35   3rd Qu.:1.0000  
##  Max.   :46.44     Max.   :200.0   Max.   :68.60   Max.   :1.7000  
##  NA's   :15                                        NA's   :4       
##     CINT_T0          CAD_T0          TAD_T0           TAS_T0     
##  Min.   : 90.0   Min.   : 85.0   Min.   : 60.00   Min.   :111.0  
##  1st Qu.:122.5   1st Qu.:136.0   1st Qu.: 74.50   1st Qu.:121.0  
##  Median :133.0   Median :148.0   Median : 83.00   Median :128.0  
##  Mean   :135.7   Mean   :147.1   Mean   : 83.58   Mean   :133.5  
##  3rd Qu.:147.5   3rd Qu.:158.5   3rd Qu.: 90.00   3rd Qu.:144.0  
##  Max.   :186.0   Max.   :182.0   Max.   :125.00   Max.   :180.0  
##  NA's   :4       NA's   :4       NA's   :8        NA's   :8      
##      TG_T0           COL_T0          LDL_T0          HDL_T0      
##  Min.   : 30.0   Min.   :102.0   Min.   : 24.0   Min.   : 11.00  
##  1st Qu.: 84.0   1st Qu.:180.5   1st Qu.:100.3   1st Qu.: 39.25  
##  Median :118.0   Median :207.0   Median :130.0   Median : 47.00  
##  Mean   :129.1   Mean   :206.6   Mean   :128.2   Mean   : 49.97  
##  3rd Qu.:151.0   3rd Qu.:236.0   3rd Qu.:158.8   3rd Qu.: 59.50  
##  Max.   :268.0   Max.   :295.0   Max.   :191.0   Max.   :107.00  
##                                  NA's   :1       NA's   :1       
##     VLDL_T0          PCR_T0          LEP_T0          ADIPO_T0     
##  Min.   : 6.00   Min.   : 0.00   Min.   : 27.00   Min.   : 1.720  
##  1st Qu.:16.80   1st Qu.: 3.51   1st Qu.: 49.25   1st Qu.: 4.700  
##  Median :23.60   Median : 8.25   Median : 67.20   Median : 7.460  
##  Mean   :25.81   Mean   :10.13   Mean   : 78.33   Mean   : 7.702  
##  3rd Qu.:30.20   3rd Qu.:13.90   3rd Qu.: 98.25   3rd Qu.: 8.590  
##  Max.   :53.60   Max.   :29.80   Max.   :155.00   Max.   :17.100  
##                  NA's   :14      NA's   :13       NA's   :14      
##      GOT_T0         GPT_T0           GGT_T0         URICO_T0    
##  Min.   :11.0   Min.   : 11.00   Min.   :12.00   Min.   :2.700  
##  1st Qu.:15.0   1st Qu.: 31.00   1st Qu.:20.00   1st Qu.:4.700  
##  Median :20.0   Median : 40.00   Median :26.00   Median :5.500  
##  Mean   :23.9   Mean   : 44.54   Mean   :31.41   Mean   :5.501  
##  3rd Qu.:25.0   3rd Qu.: 48.50   3rd Qu.:37.00   3rd Qu.:6.200  
##  Max.   :83.0   Max.   :157.00   Max.   :86.00   Max.   :8.600  
##                                  NA's   :2       NA's   :2      
##     CREAT_T0         UREA_T0        HIERRO_T0        TRANSF_T0    
##  Min.   :0.5000   Min.   :14.00   Min.   : 13.00   Min.   :159.0  
##  1st Qu.:0.7000   1st Qu.:24.00   1st Qu.: 50.00   1st Qu.:236.5  
##  Median :0.8000   Median :29.00   Median : 69.00   Median :268.5  
##  Mean   :0.7923   Mean   :31.38   Mean   : 75.61   Mean   :262.9  
##  3rd Qu.:0.9000   3rd Qu.:38.00   3rd Qu.: 92.25   3rd Qu.:289.8  
##  Max.   :1.2000   Max.   :56.00   Max.   :166.00   Max.   :374.0  
##                                   NA's   :1        NA's   :9      
##     FERR_T0           Ile_T0           Leu_T0          Val_T0     
##  Min.   : 11.10   Min.   : 53.50   Min.   : 90.1   Min.   :183.0  
##  1st Qu.: 25.00   1st Qu.: 83.55   1st Qu.:150.5   1st Qu.:256.0  
##  Median : 49.00   Median : 91.70   Median :183.0   Median :311.0  
##  Mean   : 77.06   Mean   : 98.98   Mean   :185.2   Mean   :318.4  
##  3rd Qu.: 97.00   3rd Qu.:116.00   3rd Qu.:217.0   3rd Qu.:369.5  
##  Max.   :372.00   Max.   :150.00   Max.   :281.0   Max.   :508.0  
##  NA's   :2                                                        
##      Ala_T0          Pro_T0          Gly_T0          Ser_T0     
##  Min.   :194.0   Min.   :123.0   Min.   :153.0   Min.   : 94.5  
##  1st Qu.:414.0   1st Qu.:164.5   1st Qu.:227.5   1st Qu.:133.5  
##  Median :459.0   Median :222.0   Median :270.0   Median :159.0  
##  Mean   :471.9   Mean   :234.6   Mean   :291.1   Mean   :161.4  
##  3rd Qu.:543.0   3rd Qu.:257.5   3rd Qu.:311.5   3rd Qu.:180.0  
##  Max.   :907.0   Max.   :592.0   Max.   :586.0   Max.   :310.0  
##                                                                 
##      Trp_T0           Phe_T0           Met_T0           Orn_T0     
##  Min.   : 41.00   Min.   : 48.40   Min.   :-99.00   Min.   : 39.6  
##  1st Qu.: 52.15   1st Qu.: 70.60   1st Qu.: 23.25   1st Qu.: 74.6  
##  Median : 62.30   Median : 87.30   Median : 28.30   Median :103.0  
##  Mean   : 67.22   Mean   : 87.48   Mean   : 23.08   Mean   :102.4  
##  3rd Qu.: 76.95   3rd Qu.:102.00   3rd Qu.: 33.30   3rd Qu.:128.5  
##  Max.   :123.00   Max.   :139.00   Max.   : 53.00   Max.   :195.0  
##                                                                    
##      Arg_T0          His_T0           Asn_T0          Asp_T0     
##  Min.   : 90.7   Min.   : 70.50   Min.   :27.30   Min.   : 7.10  
##  1st Qu.:120.5   1st Qu.: 80.65   1st Qu.:39.55   1st Qu.:15.65  
##  Median :143.0   Median : 94.40   Median :47.40   Median :20.50  
##  Mean   :148.5   Mean   : 97.68   Mean   :48.81   Mean   :23.12  
##  3rd Qu.:167.5   3rd Qu.:108.00   3rd Qu.:56.00   3rd Qu.:27.85  
##  Max.   :254.0   Max.   :167.00   Max.   :82.10   Max.   :59.30  
##                                                                  
##      Glu_T0           Gln_T0           Cit_T0          Tyr_T0      
##  Min.   : 16.90   Min.   : 241.0   Min.   :12.00   Min.   : 49.30  
##  1st Qu.: 51.70   1st Qu.: 628.0   1st Qu.:26.25   1st Qu.: 71.65  
##  Median : 66.40   Median : 713.0   Median :30.30   Median : 89.00  
##  Mean   : 84.68   Mean   : 749.9   Mean   :32.76   Mean   : 92.46  
##  3rd Qu.: 86.25   3rd Qu.: 872.5   3rd Qu.:38.35   3rd Qu.:108.00  
##  Max.   :351.00   Max.   :1320.0   Max.   :59.50   Max.   :162.00  
##                                                                    
##      Thr_T0          Lys_T0      Creatinine_T0    Kynurenine_T0  
##  Min.   : 67.5   Min.   :266.0   Min.   : 39.10   Min.   :1.610  
##  1st Qu.:112.0   1st Qu.:316.5   1st Qu.: 65.85   1st Qu.:2.540  
##  Median :144.0   Median :378.0   Median : 78.40   Median :3.160  
##  Mean   :151.5   Mean   :381.8   Mean   : 80.43   Mean   :3.303  
##  3rd Qu.:177.5   3rd Qu.:434.5   3rd Qu.: 99.20   3rd Qu.:3.775  
##  Max.   :286.0   Max.   :562.0   Max.   :115.00   Max.   :6.510  
##                                                                  
##  Putrescine_T0       Sarcosine_T0     Serotonin_T0        Taurine_T0    
##  Min.   :-99.0000   Min.   : 2.050   Min.   :-99.0000   Min.   : 41.00  
##  1st Qu.:  0.1295   1st Qu.: 5.895   1st Qu.:  0.3565   1st Qu.: 78.55  
##  Median :  0.2120   Median : 7.700   Median :  0.6500   Median :107.00  
##  Mean   :-12.7355   Mean   : 8.648   Mean   : -9.5029   Mean   :108.77  
##  3rd Qu.:  0.2670   3rd Qu.:12.200   3rd Qu.:  0.9180   3rd Qu.:132.50  
##  Max.   :  0.3660   Max.   :15.700   Max.   :  1.8100   Max.   :181.00  
##                                                                         
##     SDMA_T0          C0_T0           C2_T0           C3.OH_T0     
##  Min.   :0.820   Min.   :21.60   Min.   : 0.360   Min.   :0.1500  
##  1st Qu.:1.115   1st Qu.:36.00   1st Qu.: 5.215   1st Qu.:0.2100  
##  Median :1.290   Median :43.30   Median : 7.270   Median :0.2400  
##  Mean   :1.317   Mean   :45.60   Mean   : 7.762   Mean   :0.2474  
##  3rd Qu.:1.535   3rd Qu.:52.05   3rd Qu.: 9.200   3rd Qu.:0.2800  
##  Max.   :1.940   Max.   :79.30   Max.   :19.500   Max.   :0.3700  
##                                                                   
##  C6..C4.1.DC._T0   C5.DC..C6.OH._T0     C7.DC_T0           C8_T0       
##  Min.   :-99.000   Min.   :-9.0000   Min.   :-9.0000   Min.   :0.3230  
##  1st Qu.: -9.000   1st Qu.: 0.0410   1st Qu.: 0.0395   1st Qu.:0.4385  
##  Median :  0.094   Median : 0.0490   Median : 0.0470   Median :0.5190  
##  Mean   :-14.232   Mean   :-1.1096   Mean   :-1.1098   Mean   :0.5419  
##  3rd Qu.:  0.118   3rd Qu.: 0.0565   3rd Qu.: 0.0555   3rd Qu.:0.6235  
##  Max.   :  0.201   Max.   : 0.0780   Max.   : 0.0760   Max.   :0.8710  
##                                                                        
##      C10_T0          C10.1_T0         C10.2_T0         C14.1_T0     
##  Min.   :0.2500   Min.   :0.1300   Min.   :0.1000   Min.   :0.0900  
##  1st Qu.:0.4200   1st Qu.:0.1900   1st Qu.:0.1300   1st Qu.:0.1450  
##  Median :0.5200   Median :0.2300   Median :0.1500   Median :0.1900  
##  Mean   :0.5274   Mean   :0.2482   Mean   :0.1621   Mean   :0.1944  
##  3rd Qu.:0.6350   3rd Qu.:0.3050   3rd Qu.:0.1850   3rd Qu.:0.2450  
##  Max.   :0.9300   Max.   :0.4200   Max.   :0.2600   Max.   :0.3000  
##                                                                     
##     C14.2_T0         C16.1_T0         C16.2_T0        C16.2.OH_T0     
##  Min.   :0.0600   Min.   :0.0600   Min.   :0.03000   Min.   :0.00000  
##  1st Qu.:0.1000   1st Qu.:0.0900   1st Qu.:0.03000   1st Qu.:0.04000  
##  Median :0.1200   Median :0.1000   Median :0.04000   Median :0.04000  
##  Mean   :0.1244   Mean   :0.1126   Mean   :0.04487   Mean   :0.04385  
##  3rd Qu.:0.1400   3rd Qu.:0.1300   3rd Qu.:0.05000   3rd Qu.:0.05500  
##  Max.   :0.2100   Max.   :0.1900   Max.   :0.08000   Max.   :0.07000  
##                                                                       
##     C18.1_T0       C18.1.OH_T0         C18.2_T0      lysoPC.a.C16.0_T0
##  Min.   :0.0700   Min.   :0.03000   Min.   :0.0600   Min.   : 72.3    
##  1st Qu.:0.1200   1st Qu.:0.04000   1st Qu.:0.0900   1st Qu.:118.5    
##  Median :0.1600   Median :0.04000   Median :0.1100   Median :144.0    
##  Mean   :0.1703   Mean   :0.04615   Mean   :0.1074   Mean   :151.7    
##  3rd Qu.:0.2150   3rd Qu.:0.05000   3rd Qu.:0.1300   3rd Qu.:174.0    
##  Max.   :0.2900   Max.   :0.07000   Max.   :0.1700   Max.   :308.0    
##                                                                       
##  lysoPC.a.C16.1_T0 lysoPC.a.C17.0_T0 lysoPC.a.C18.0_T0 lysoPC.a.C18.1_T0
##  Min.   :1.940     Min.   :0.790     Min.   : 14.30    Min.   :12.70    
##  1st Qu.:2.870     1st Qu.:1.445     1st Qu.: 34.05    1st Qu.:22.25    
##  Median :3.810     Median :2.110     Median : 45.20    Median :28.80    
##  Mean   :4.283     Mean   :2.101     Mean   : 50.51    Mean   :32.32    
##  3rd Qu.:5.500     3rd Qu.:2.425     3rd Qu.: 60.70    3rd Qu.:40.55    
##  Max.   :9.890     Max.   :4.340     Max.   :120.00    Max.   :58.20    
##                                                                         
##  lysoPC.a.C18.2_T0 lysoPC.a.C20.3_T0 lysoPC.a.C20.4_T0 lysoPC.a.C24.0_T0
##  Min.   : 19.10    Min.   :1.190     Min.   : 4.21     Min.   :0.2400   
##  1st Qu.: 34.75    1st Qu.:2.940     1st Qu.: 7.50     1st Qu.:0.3500   
##  Median : 39.90    Median :4.090     Median :10.50     Median :0.4600   
##  Mean   : 43.82    Mean   :4.373     Mean   :10.77     Mean   :0.4974   
##  3rd Qu.: 50.75    3rd Qu.:5.335     3rd Qu.:13.55     3rd Qu.:0.5550   
##  Max.   :109.00    Max.   :9.410     Max.   :19.60     Max.   :0.9200   
##                                                                         
##  lysoPC.a.C26.0_T0 lysoPC.a.C26.1_T0 lysoPC.a.C28.0_T0 lysoPC.a.C28.1_T0
##  Min.   :-9.0000   Min.   :0.1200    Min.   :-9.0000   Min.   :0.2400   
##  1st Qu.: 0.3100   1st Qu.:0.2600    1st Qu.: 0.2650   1st Qu.:0.3800   
##  Median : 0.4200   Median :0.3300    Median : 0.3400   Median :0.4600   
##  Mean   : 0.2841   Mean   :0.3408    Mean   :-0.7536   Mean   :0.5238   
##  3rd Qu.: 0.5050   3rd Qu.:0.4150    3rd Qu.: 0.4100   3rd Qu.:0.5900   
##  Max.   : 2.1300   Max.   :0.6600    Max.   : 1.7200   Max.   :1.5000   
##                                                                         
##  PC.aa.C24.0_T0   PC.aa.C28.1_T0  PC.aa.C30.0_T0  PC.aa.C32.0_T0  
##  Min.   :-9.000   Min.   :1.970   Min.   :0.630   Min.   : 5.360  
##  1st Qu.: 0.145   1st Qu.:2.380   1st Qu.:1.420   1st Qu.: 8.525  
##  Median : 0.180   Median :2.910   Median :1.710   Median :10.200  
##  Mean   :-1.650   Mean   :3.014   Mean   :1.895   Mean   :10.695  
##  3rd Qu.: 0.250   3rd Qu.:3.640   3rd Qu.:2.305   3rd Qu.:12.100  
##  Max.   : 0.780   Max.   :4.770   Max.   :3.520   Max.   :17.300  
##                                                                   
##  PC.aa.C32.1_T0  PC.aa.C32.3_T0   PC.aa.C34.1_T0   PC.aa.C34.2_T0 
##  Min.   : 2.64   Min.   :0.1200   Min.   : 50.60   Min.   :154.0  
##  1st Qu.: 7.11   1st Qu.:0.1750   1st Qu.: 99.75   1st Qu.:245.0  
##  Median :10.50   Median :0.2400   Median :136.00   Median :302.0  
##  Mean   :11.77   Mean   :0.2362   Mean   :139.15   Mean   :338.7  
##  3rd Qu.:12.80   3rd Qu.:0.2800   3rd Qu.:161.00   3rd Qu.:389.5  
##  Max.   :29.60   Max.   :0.4400   Max.   :310.00   Max.   :904.0  
##                                                                   
##  PC.aa.C34.3_T0  PC.aa.C34.4_T0   PC.aa.C36.0_T0  PC.aa.C36.1_T0 
##  Min.   : 3.94   Min.   :0.2000   Min.   :0.610   Min.   : 8.40  
##  1st Qu.: 6.34   1st Qu.:0.3700   1st Qu.:1.030   1st Qu.:13.30  
##  Median : 9.73   Median :0.6300   Median :1.300   Median :15.70  
##  Mean   :10.29   Mean   :0.7015   Mean   :1.568   Mean   :18.32  
##  3rd Qu.:11.00   3rd Qu.:0.9050   3rd Qu.:1.880   3rd Qu.:23.00  
##  Max.   :24.40   Max.   :1.8600   Max.   :4.560   Max.   :43.30  
##                                                                  
##  PC.aa.C36.2_T0  PC.aa.C36.3_T0   PC.aa.C36.4_T0   PC.aa.C36.5_T0  
##  Min.   : 60.6   Min.   : 36.60   Min.   : 40.10   Min.   : 2.770  
##  1st Qu.: 89.8   1st Qu.: 58.90   1st Qu.: 95.15   1st Qu.: 6.595  
##  Median :112.0   Median : 69.80   Median :120.00   Median : 9.200  
##  Mean   :125.9   Mean   : 78.45   Mean   :120.26   Mean   : 9.591  
##  3rd Qu.:151.0   3rd Qu.: 91.20   3rd Qu.:149.50   3rd Qu.:11.750  
##  Max.   :282.0   Max.   :187.00   Max.   :214.00   Max.   :23.700  
##                                                                    
##  PC.aa.C38.0_T0  PC.aa.C38.1_T0   PC.aa.C38.3_T0   PC.aa.C38.4_T0  
##  Min.   :1.340   Min.   :-9.000   Min.   : 16.90   Min.   : 34.20  
##  1st Qu.:2.385   1st Qu.: 0.910   1st Qu.: 29.15   1st Qu.: 66.85  
##  Median :3.000   Median : 1.100   Median : 37.40   Median : 92.20  
##  Mean   :3.258   Mean   : 1.219   Mean   : 41.54   Mean   : 92.36  
##  3rd Qu.:3.960   3rd Qu.: 1.625   3rd Qu.: 51.25   3rd Qu.:111.50  
##  Max.   :6.180   Max.   : 6.230   Max.   :110.00   Max.   :164.00  
##                                                                    
##  PC.aa.C38.5_T0  PC.aa.C38.6_T0   PC.aa.C40.1_T0   PC.aa.C40.2_T0  
##  Min.   :11.20   Min.   : 13.90   Min.   :-9.000   Min.   :0.1700  
##  1st Qu.:20.55   1st Qu.: 43.90   1st Qu.: 0.335   1st Qu.:0.2300  
##  Median :29.50   Median : 56.70   Median : 0.460   Median :0.3400  
##  Mean   :28.74   Mean   : 62.95   Mean   :-1.550   Mean   :0.6377  
##  3rd Qu.:36.75   3rd Qu.: 77.45   3rd Qu.: 0.565   3rd Qu.:0.4300  
##  Max.   :47.70   Max.   :128.00   Max.   : 3.330   Max.   :5.7700  
##                                                                    
##  PC.aa.C40.3_T0  PC.aa.C40.4_T0  PC.aa.C40.5_T0   PC.aa.C40.6_T0 
##  Min.   :0.370   Min.   :1.080   Min.   : 1.750   Min.   : 5.39  
##  1st Qu.:0.490   1st Qu.:1.860   1st Qu.: 3.680   1st Qu.:16.15  
##  Median :0.580   Median :2.500   Median : 4.910   Median :19.50  
##  Mean   :0.871   Mean   :2.777   Mean   : 5.178   Mean   :22.21  
##  3rd Qu.:0.780   3rd Qu.:3.385   3rd Qu.: 6.185   3rd Qu.:29.65  
##  Max.   :4.820   Max.   :5.970   Max.   :11.100   Max.   :41.10  
##                                                                  
##  PC.aa.C42.0_T0   PC.aa.C42.1_T0   PC.aa.C42.2_T0   PC.aa.C42.4_T0  
##  Min.   :0.3700   Min.   :0.2000   Min.   :0.1600   Min.   :0.1100  
##  1st Qu.:0.5600   1st Qu.:0.2750   1st Qu.:0.2150   1st Qu.:0.1800  
##  Median :0.6800   Median :0.3500   Median :0.2800   Median :0.2200  
##  Mean   :0.7562   Mean   :0.4087   Mean   :0.4064   Mean   :0.3379  
##  3rd Qu.:0.8700   3rd Qu.:0.4250   3rd Qu.:0.3300   3rd Qu.:0.2450  
##  Max.   :1.7400   Max.   :1.3800   Max.   :2.3100   Max.   :2.6100  
##                                                                     
##  PC.aa.C42.5_T0   PC.aa.C42.6_T0     PC.ae.C30.0_T0   PC.ae.C32.1_T0 
##  Min.   :0.1300   Min.   :-9.00000   Min.   :0.2100   Min.   :1.220  
##  1st Qu.:0.2600   1st Qu.: 0.27500   1st Qu.:0.2700   1st Qu.:1.675  
##  Median :0.3200   Median : 0.34000   Median :0.3300   Median :2.160  
##  Mean   :0.3818   Mean   :-0.08128   Mean   :0.3262   Mean   :2.219  
##  3rd Qu.:0.4000   3rd Qu.: 0.42500   3rd Qu.:0.3600   3rd Qu.:2.625  
##  Max.   :1.4400   Max.   : 1.09000   Max.   :0.5000   Max.   :4.120  
##                                                                      
##  PC.ae.C32.2_T0   PC.ae.C34.0_T0  PC.ae.C34.1_T0  PC.ae.C34.2_T0  
##  Min.   :0.3500   Min.   :0.250   Min.   :2.760   Min.   : 3.030  
##  1st Qu.:0.5450   1st Qu.:0.390   1st Qu.:4.135   1st Qu.: 5.310  
##  Median :0.6700   Median :0.470   Median :4.850   Median : 6.170  
##  Mean   :0.6997   Mean   :0.511   Mean   :5.147   Mean   : 7.382  
##  3rd Qu.:0.8300   3rd Qu.:0.630   3rd Qu.:6.395   3rd Qu.: 8.590  
##  Max.   :1.2000   Max.   :0.840   Max.   :9.350   Max.   :19.000  
##                                                                   
##  PC.ae.C34.3_T0   PC.ae.C36.0_T0  PC.ae.C36.1_T0   PC.ae.C36.2_T0  
##  Min.   : 1.450   Min.   :0.470   Min.   : 1.510   Min.   : 3.230  
##  1st Qu.: 3.285   1st Qu.:0.760   1st Qu.: 2.310   1st Qu.: 4.390  
##  Median : 4.140   Median :0.940   Median : 3.120   Median : 5.210  
##  Mean   : 4.581   Mean   :1.008   Mean   : 3.922   Mean   : 5.852  
##  3rd Qu.: 5.030   3rd Qu.:1.135   3rd Qu.: 3.695   3rd Qu.: 6.965  
##  Max.   :10.100   Max.   :1.980   Max.   :18.200   Max.   :10.800  
##                                                                    
##  PC.ae.C36.3_T0   PC.ae.C36.4_T0   PC.ae.C36.5_T0   PC.ae.C38.0_T0 
##  Min.   : 1.660   Min.   : 2.180   Min.   : 1.760   Min.   :0.490  
##  1st Qu.: 2.710   1st Qu.: 6.490   1st Qu.: 4.950   1st Qu.:1.265  
##  Median : 3.120   Median : 7.940   Median : 6.240   Median :1.630  
##  Mean   : 3.812   Mean   : 8.826   Mean   : 6.642   Mean   :1.623  
##  3rd Qu.: 4.610   3rd Qu.:10.850   3rd Qu.: 8.215   3rd Qu.:1.945  
##  Max.   :11.000   Max.   :20.100   Max.   :13.100   Max.   :2.960  
##                                                                    
##  PC.ae.C38.2_T0   PC.ae.C38.3_T0   PC.ae.C38.4_T0   PC.ae.C38.5_T0  
##  Min.   : 0.350   Min.   : 0.830   Min.   : 3.100   Min.   : 3.370  
##  1st Qu.: 1.195   1st Qu.: 1.250   1st Qu.: 4.440   1st Qu.: 7.470  
##  Median : 1.580   Median : 1.530   Median : 5.480   Median : 8.610  
##  Mean   : 2.752   Mean   : 2.235   Mean   : 5.729   Mean   : 9.477  
##  3rd Qu.: 2.115   3rd Qu.: 1.990   3rd Qu.: 6.425   3rd Qu.:10.500  
##  Max.   :25.500   Max.   :11.200   Max.   :11.100   Max.   :19.200  
##                                                                     
##  PC.ae.C38.6_T0  PC.ae.C40.1_T0  PC.ae.C40.2_T0  PC.ae.C40.3_T0  
##  Min.   :1.380   Min.   :0.450   Min.   :0.620   Min.   : 0.560  
##  1st Qu.:2.715   1st Qu.:0.895   1st Qu.:0.965   1st Qu.: 0.740  
##  Median :3.740   Median :1.160   Median :1.170   Median : 0.880  
##  Mean   :3.995   Mean   :1.373   Mean   :1.557   Mean   : 1.574  
##  3rd Qu.:4.915   3rd Qu.:1.570   3rd Qu.:1.390   3rd Qu.: 1.160  
##  Max.   :7.690   Max.   :4.540   Max.   :8.440   Max.   :11.400  
##                                                                  
##  PC.ae.C40.4_T0  PC.ae.C40.5_T0  PC.ae.C40.6_T0  PC.ae.C42.1_T0  
##  Min.   :1.020   Min.   :1.050   Min.   :1.340   Min.   :0.2100  
##  1st Qu.:1.645   1st Qu.:1.570   1st Qu.:1.700   1st Qu.:0.3600  
##  Median :1.940   Median :1.790   Median :2.200   Median :0.4300  
##  Mean   :2.380   Mean   :2.317   Mean   :2.309   Mean   :0.6195  
##  3rd Qu.:2.610   3rd Qu.:2.385   3rd Qu.:3.035   3rd Qu.:0.5650  
##  Max.   :7.970   Max.   :8.690   Max.   :3.540   Max.   :3.4000  
##                                                                  
##  PC.ae.C42.2_T0   PC.ae.C42.3_T0  
##  Min.   :0.2900   Min.   :0.4600  
##  1st Qu.:0.3800   1st Qu.:0.6050  
##  Median :0.4700   Median :0.7900  
##  Mean   :0.6236   Mean   :0.9569  
##  3rd Qu.:0.6100   3rd Qu.:0.9450  
##  Max.   :2.8200   Max.   :4.1900  
## 

Veiem que la variabilitat en els rangs és molt elevada i, per tant, caldrà normalitzar les dades. Recordem també que tenim un nombre de NAs força elevat.

5.2. Preprocessat

Amb el que hem pogut veure fins aquó de les dades que tenim és que ens calen dos procesos per poder començar els anàlisi multivariants:

  1. Imputar els missing values
  2. Normalitzar les dades

Això ho podem fer amb POMA que al mateix temps ens permet fer algun boxplot

# primer instal·lem el paquet i les llibreries
# BiocManager::install("POMA") # Això només el primer cop per instal·lar el paquet
library(POMA)
## Welcome to POMA!
## Version 1.16.0
## POMAShiny app: https://github.com/pcastellanoescuder/POMAShiny
library(ggtext)
## Warning: package 'ggtext' was built under R version 4.4.3
library(magrittr)
## 
## Attaching package: 'magrittr'
## The following object is masked from 'package:GenomicRanges':
## 
##     subtract

Ataquem primer la imputació.

Abans de fer-la cal dir que no podem imputar NA en columnes on no tenim cap valor. Per tant, mirem si hi ha alguna columna que no tingui cap valor i l’eliminem.

# Busquem columnes amb tot NAs
eliminats = c()
for (i in 1:685)
  if (sum(is.na(assay(seMA)[,i])) == 39)
  {print((paste(i, sum(is.na(assay(seMA)[,i])))))
    eliminats = c(eliminats, i)}
## [1] "248 39"

Eliminem per tant, la columna 248

seMAclean <- seMA[,-eliminats]

I fem la imputació dels NA utilitzant el knn que és possiblement el mètode més robust per fer-ho

seMAimputed <- seMAclean %>%
  PomaImpute(method = "knn", zeros_as_na = FALSE, remove_na = FALSE, cutoff = 20)
## -39 features removed.

Després comprovem que no tenim NAs

sum(is.na(assay(seMAimputed)))
## [1] 0

Doncs ara, ha podem normalitzar les dades. D’entre els mètodes que es poden utilitzar hem rebutjat els logaritmes perquè amb les dades que tenim ens generen NAs, ek mix_max perquè genera molta variabilitat en les dades en el nostre cas i el box_cox perquè no funciona amb la matriu que tenim.

Ens queden els dos mètodes d’escalat i el auto_scaling és el que dona el gràfic més homogeni. Així que ens quedem amb aquest

# Ensenyem el resultat de min_max per veure que les funcions de densitat són molt variables
seMAnormalized <- seMAimputed %>% 
  PomaNorm(method = "min_max")
PomaDensity(seMAnormalized, x = "features")

# Ensenyem el resultat de min_max per veure que les funcions de densitat són molt variables
seMAnormalized <- seMAimputed %>% 
  PomaNorm(method = "auto_scaling")
PomaDensity(seMAnormalized, x = "features")

Sembla que hi ha algun outlier, però crec que no és preocupant

5.4. Analisi univariant

L’anàlisi univariant no té massa sentit amb una matriu tant gran de dades, però per provar alguna cosa, podem dir que fer alguns histogrames no està de mas. Farem 9 de les variables per veure una mica com es distribueixen després del preprocessament

opt <- par(mfrow=c(3,3))
for (i in 1:9)
  hist(assay(seMAnormalized)[,i], 
       xlab = colData(seMAnormalized)[i,2], 
       main = colData(seMAnormalized)[i,2])

par(opt)

Podem apreciar que les distribucions no són molt homogenies, el que potser implica poques correlacions. Veurem més endavant

6. Reducció de les dimensions

Un pas important ara que hem vist com són les variables pot ser fer un Anàlisi de Components Principals (PCA)). Com que tenim els NAs eliminats i les dades normalitzades, podem fer-lo sense problemes addicionals.

PCAseMA <- prcomp(assay(seMAnormalized), scale. = TRUE)
PCAseMA
## Standard deviations (1, .., p=39):
##  [1] 1.893256e+01 7.377935e+00 5.806778e+00 5.366514e+00 5.212884e+00
##  [6] 4.421286e+00 4.032098e+00 3.610802e+00 3.464758e+00 2.993985e+00
## [11] 2.905096e+00 2.840228e+00 2.671005e+00 2.633563e+00 2.591891e+00
## [16] 2.550440e+00 2.438817e+00 2.282599e+00 2.222872e+00 2.118927e+00
## [21] 2.067725e+00 2.042961e+00 1.985076e+00 1.889037e+00 1.853185e+00
## [26] 1.802430e+00 1.759200e+00 1.735222e+00 1.711374e+00 1.624513e+00
## [31] 1.531975e+00 1.494274e+00 1.382320e+00 1.374211e+00 1.328333e+00
## [36] 1.224837e+00 1.109147e+00 1.021286e+00 1.161219e-14
## 
## Rotation (n x k) = (685 x 39):
##                             PC1           PC2           PC3           PC4
## GLU_T0            -1.199624e-02  4.941264e-02 -2.319322e-02 -1.078391e-02
## INS_T0            -3.040036e-02  5.672071e-02 -2.721737e-02  2.233584e-02
## HOMA_T0           -4.080096e-02  3.104342e-02 -2.125132e-02  7.222602e-03
## HBA1C_T0          -4.651415e-02 -1.834343e-02  2.008314e-02 -5.565033e-04
## HBA1C.mmol.mol_T0  3.552732e-02 -9.188496e-03  2.104319e-02  4.572940e-04
## PESO_T0           -2.326499e-02  8.125680e-02 -3.630520e-02 -3.611425e-03
## bmi_T0            -2.471270e-02  8.087699e-02 -3.633006e-02  1.303281e-02
## CC_T0             -5.244727e-02 -1.569056e-03  6.832376e-03  6.712868e-03
## CINT_T0           -2.108588e-02  1.005267e-01 -1.260106e-02  2.898376e-02
## CAD_T0            -1.094508e-02  1.031612e-01 -1.546234e-02 -6.292826e-03
## TAD_T0             3.368663e-02 -5.542617e-03  1.880689e-02 -1.076498e-02
## TAS_T0             4.155077e-02 -5.256121e-04  3.309474e-03 -4.469568e-03
## TG_T0              4.626877e-03  2.775474e-02 -5.204236e-02  5.830628e-02
## COL_T0            -3.209452e-03  4.890035e-02 -1.392578e-02  2.888548e-02
## LDL_T0            -9.495424e-03  6.748697e-02 -1.252003e-02  2.204182e-02
## HDL_T0             6.530946e-04 -3.647308e-02  2.226752e-02 -1.236797e-02
## VLDL_T0           -4.486175e-03  2.630072e-02 -5.128724e-02  5.894473e-02
## PCR_T0            -1.594345e-02 -2.534249e-02  2.709684e-02 -1.312719e-02
## LEP_T0            -2.977204e-02  5.974349e-02 -1.459339e-02  5.927173e-03
## ADIPO_T0          -2.157399e-02  5.445112e-03 -1.229830e-02 -2.448064e-02
## GOT_T0            -1.097243e-02  3.930316e-03  3.068829e-02  3.609539e-03
## GPT_T0            -1.042910e-02  6.848081e-03 -1.324231e-02 -8.294370e-03
## GGT_T0            -2.106519e-02  5.718606e-02 -4.429951e-02  4.709703e-02
## URICO_T0          -4.690040e-02  3.257911e-02 -1.050633e-02  2.145387e-02
## CREAT_T0          -5.238177e-02 -4.462782e-03  7.125217e-03  3.583363e-04
## UREA_T0           -1.102555e-02  4.186594e-02 -8.738753e-03  3.110859e-02
## HIERRO_T0         -3.876584e-03  4.665753e-02 -5.411954e-03  2.833490e-02
## TRANSF_T0          3.990148e-02 -6.735974e-03  1.411681e-02  2.756888e-02
## FERR_T0            1.100355e-02  2.202379e-02  1.604286e-02  1.859058e-03
## Ile_T0            -9.979157e-03  4.347839e-02 -8.025407e-02  3.102797e-02
## Leu_T0            -1.901120e-03  3.243955e-02 -8.925402e-02  2.524131e-02
## Val_T0             1.370998e-03  2.254413e-02 -9.141408e-02  3.520201e-02
## Ala_T0            -5.657694e-03  5.095690e-02 -1.196257e-01  2.891007e-02
## Pro_T0            -2.375758e-02  4.844247e-02 -8.208939e-02 -1.149389e-02
## Gly_T0            -1.004746e-02  3.877661e-02 -6.471853e-02 -2.918055e-02
## Ser_T0            -1.665486e-02  5.123520e-02 -7.174336e-02 -1.949394e-02
## Trp_T0            -1.706001e-02  1.060458e-02 -9.699474e-02  2.718742e-02
## Phe_T0            -8.719772e-03  4.965718e-02 -1.062346e-01  1.202598e-04
## Met_T0             2.364641e-02 -8.029138e-02  4.323907e-02 -2.661267e-02
## Orn_T0            -9.794162e-03  4.300912e-03 -8.253731e-02  2.358071e-02
## Arg_T0            -8.207693e-03  7.242484e-02 -9.691286e-02  5.283762e-02
## His_T0            -1.961687e-02  3.543715e-02 -1.080403e-01 -6.512983e-03
## Asn_T0            -2.278992e-02 -1.581569e-02 -2.588730e-02 -2.529066e-02
## Asp_T0            -2.454699e-02  7.611141e-02 -6.003059e-02  3.112978e-02
## Glu_T0            -1.891976e-02  9.132817e-02 -6.796917e-02  5.490545e-02
## Gln_T0            -6.384554e-03 -5.760449e-02 -2.247765e-02 -7.017922e-02
## Cit_T0            -3.067717e-02  4.560629e-02 -3.427953e-02  3.033582e-02
## Tyr_T0            -1.926940e-02  2.538624e-02 -1.016609e-01  1.033410e-02
## Thr_T0            -3.264978e-03 -2.056393e-02 -4.111030e-02  1.093298e-02
## Lys_T0            -6.434112e-03  1.624795e-02 -1.015303e-01  4.084040e-02
## Creatinine_T0     -1.030747e-02  5.069871e-02 -3.989496e-02 -1.454879e-03
## Kynurenine_T0     -4.960725e-02 -3.669416e-03 -2.642139e-02 -9.883789e-04
## Putrescine_T0     -7.308058e-03 -6.104151e-04 -1.309582e-02  5.102346e-03
## Sarcosine_T0      -3.160741e-02  4.123728e-02 -1.020420e-02  2.945476e-02
## Serotonin_T0      -7.413211e-03 -7.621286e-03  4.666980e-02  5.402820e-03
## Taurine_T0        -1.772370e-02  3.613755e-02 -3.522009e-02  1.739916e-02
## SDMA_T0           -5.241650e-02 -2.826580e-03  3.299265e-03  6.957672e-04
## C0_T0             -2.576613e-02  4.587907e-02 -8.069356e-02  4.560331e-02
## C2_T0             -2.218579e-02 -2.907379e-02  3.813234e-02 -2.346379e-02
## C3.OH_T0          -5.247407e-02 -8.697286e-03  6.063526e-03  1.223400e-03
## C6..C4.1.DC._T0    3.267974e-03  3.041575e-02  4.521626e-02  1.201054e-02
## C5.DC..C6.OH._T0  -3.565798e-02 -1.456302e-02  3.969868e-03  1.830535e-02
## C7.DC_T0          -3.495627e-02 -5.186282e-03  6.317214e-03 -5.121927e-03
## C8_T0             -5.250656e-02 -7.142245e-03  5.207529e-03  2.284466e-03
## C10_T0            -5.251524e-02 -5.433485e-03  3.792803e-03  2.205449e-03
## C10.1_T0          -5.249195e-02 -8.578609e-03  4.615177e-03  1.155361e-03
## C10.2_T0          -5.245744e-02 -8.645811e-03  6.548846e-03  1.100308e-03
## C14.1_T0          -5.249986e-02 -8.257121e-03  5.865208e-03  1.783103e-03
## C14.2_T0          -5.247850e-02 -8.609041e-03  6.262901e-03  1.412700e-03
## C16.1_T0          -5.248726e-02 -8.523857e-03  6.458853e-03  1.373352e-03
## C16.2_T0          -5.246910e-02 -9.095494e-03  6.594646e-03  1.459950e-03
## C16.2.OH_T0       -5.247213e-02 -9.103851e-03  6.569942e-03  1.380622e-03
## C18.1_T0          -5.253721e-02 -7.752416e-03  5.969628e-03  1.142369e-03
## C18.1.OH_T0       -5.246717e-02 -9.145540e-03  6.585084e-03  1.396145e-03
## C18.2_T0          -5.248329e-02 -8.754111e-03  6.588226e-03  1.652488e-03
## lysoPC.a.C16.0_T0 -1.888892e-02  7.119173e-02 -1.024627e-01  3.386555e-02
## lysoPC.a.C16.1_T0 -4.645715e-02  2.996157e-02 -5.568621e-02  1.882351e-02
## lysoPC.a.C17.0_T0 -5.085825e-02  1.727304e-02 -1.904967e-02  1.555739e-02
## lysoPC.a.C18.0_T0 -1.950736e-02  5.616350e-02 -1.097307e-01  3.486232e-02
## lysoPC.a.C18.1_T0 -2.845384e-02  5.606669e-02 -7.789242e-02  2.511448e-02
## lysoPC.a.C18.2_T0 -2.672044e-02  1.336755e-02 -8.544482e-02  9.233331e-03
## lysoPC.a.C20.3_T0 -4.491626e-02  2.014642e-03 -5.759618e-02  2.154599e-02
## lysoPC.a.C20.4_T0 -3.186501e-02  3.680045e-02 -4.321636e-02  1.251284e-02
## lysoPC.a.C24.0_T0 -5.259933e-02 -4.423072e-03  1.436010e-03  2.071438e-03
## lysoPC.a.C26.0_T0 -4.635546e-02 -8.375227e-04 -1.651850e-02  2.296390e-02
## lysoPC.a.C26.1_T0 -5.260177e-02 -4.112828e-03  3.559603e-03  7.598541e-04
## lysoPC.a.C28.0_T0 -3.820598e-02 -1.176691e-02 -3.463173e-02  1.541886e-02
## lysoPC.a.C28.1_T0 -5.268437e-02  9.811227e-04 -1.621543e-03  3.456510e-03
## PC.aa.C24.0_T0    -3.450394e-02  1.405759e-02 -1.144507e-02 -1.788179e-02
## PC.aa.C28.1_T0    -5.090210e-02 -5.572934e-03 -8.989270e-03  1.676002e-03
## PC.aa.C30.0_T0    -5.076110e-02 -1.062761e-02 -4.171637e-03  5.860590e-03
## PC.aa.C32.0_T0    -4.047902e-02 -1.049841e-02 -2.208971e-02 -5.985915e-03
## PC.aa.C32.1_T0    -2.933937e-02 -4.226707e-03 -5.208939e-02  1.485087e-02
## PC.aa.C32.3_T0    -5.254305e-02 -8.265740e-03  4.482921e-03  2.645503e-03
## PC.aa.C34.1_T0    -4.679961e-03 -2.399894e-03 -5.577084e-02  2.887736e-02
## PC.aa.C34.2_T0    -5.839240e-03 -5.785504e-02 -3.948971e-02  3.145463e-02
## PC.aa.C34.3_T0    -3.396562e-02 -2.782546e-02 -5.344318e-02  2.916803e-02
## PC.aa.C34.4_T0    -5.193914e-02 -1.288689e-02 -9.518723e-04  7.521392e-03
## PC.aa.C36.0_T0    -5.113143e-02  1.940279e-02 -1.720350e-02  1.913615e-02
## PC.aa.C36.1_T0    -2.407247e-02 -2.667213e-03 -7.121721e-02  5.948390e-02
## PC.aa.C36.2_T0    -8.060236e-03 -4.625739e-02 -6.466646e-02  3.938564e-02
## PC.aa.C36.3_T0    -6.934274e-03 -4.507168e-02 -5.754152e-02  4.404455e-02
## PC.aa.C36.4_T0     7.269459e-03 -1.944508e-02 -3.726738e-03  2.456261e-02
## PC.aa.C36.5_T0    -2.377410e-02  1.315630e-02 -1.724130e-02  5.942156e-02
## PC.aa.C38.0_T0    -4.909721e-02  1.107830e-02 -2.123144e-02  1.879520e-02
## PC.aa.C38.1_T0    -4.226607e-02  3.070666e-02 -3.542939e-04  3.360842e-02
## PC.aa.C38.3_T0    -7.449456e-03 -2.944195e-02 -8.810957e-02  4.505764e-02
## PC.aa.C38.4_T0     4.819443e-03 -1.588009e-02 -3.221724e-02  1.804556e-02
## PC.aa.C38.5_T0    -8.793357e-03 -1.005540e-02 -2.803464e-02  3.987593e-02
## PC.aa.C38.6_T0     3.682175e-03 -5.666075e-03 -2.843888e-03  1.717111e-02
## PC.aa.C40.1_T0    -3.532944e-02 -7.802958e-03 -5.990080e-02  3.450067e-02
## PC.aa.C40.2_T0    -4.948016e-02  2.974843e-02 -2.947529e-02  2.070395e-02
## PC.aa.C40.3_T0    -5.078606e-02  2.243592e-02 -2.445202e-02  1.596725e-02
## PC.aa.C40.4_T0    -4.967989e-02  1.463772e-02 -4.116538e-02  2.311102e-02
## PC.aa.C40.5_T0    -4.508810e-02 -1.838723e-02 -3.328628e-02  1.524805e-02
## PC.aa.C40.6_T0    -6.193391e-03 -4.759122e-03 -2.173514e-02  3.784442e-02
## PC.aa.C42.0_T0    -5.263114e-02  3.232547e-03 -4.267086e-03  5.772590e-03
## PC.aa.C42.1_T0    -5.270876e-02  1.840187e-03 -2.633491e-03  5.705166e-03
## PC.aa.C42.2_T0    -5.235307e-02  9.994660e-03 -1.034820e-02  9.934093e-03
## PC.aa.C42.4_T0    -5.233352e-02  7.367583e-03 -1.202856e-02  9.351755e-03
## PC.aa.C42.5_T0    -5.269167e-02 -1.287353e-03 -3.441852e-03  4.735824e-03
## PC.aa.C42.6_T0    -4.304304e-02 -4.360666e-03 -1.269944e-02  1.956059e-02
## PC.ae.C30.0_T0    -5.254257e-02 -7.763565e-03  3.942071e-03  1.377721e-03
## PC.ae.C32.1_T0    -5.134015e-02 -1.054594e-02 -4.191666e-03 -3.771758e-03
## PC.ae.C32.2_T0    -5.254671e-02 -7.489553e-03  4.855983e-04  2.477391e-03
## PC.ae.C34.0_T0    -5.252130e-02 -7.244882e-03  4.246375e-03  3.879746e-03
## PC.ae.C34.1_T0    -4.894199e-02 -1.066988e-02 -7.958685e-03  5.977845e-03
## PC.ae.C34.2_T0    -3.815767e-02 -3.850930e-02 -2.519837e-02  1.399627e-02
## PC.ae.C34.3_T0    -4.339116e-02 -3.679685e-02 -1.527740e-02  6.648265e-03
## PC.ae.C36.0_T0    -5.256366e-02  2.609808e-03 -5.873801e-03  8.648078e-03
## PC.ae.C36.1_T0    -3.954970e-02  6.158932e-02 -5.052192e-02  3.778079e-02
## PC.ae.C36.2_T0    -4.722815e-02  1.147999e-02 -1.985515e-02  2.980044e-02
## PC.ae.C36.3_T0    -4.564989e-02 -2.815843e-02 -1.852507e-02  1.615099e-02
## PC.ae.C36.4_T0    -3.142224e-02 -3.911879e-02 -2.895686e-02  1.854032e-02
## PC.ae.C36.5_T0    -3.810759e-02 -3.191308e-02 -1.404708e-02  1.430391e-02
## PC.ae.C38.0_T0    -5.176857e-02 -5.287911e-03 -5.684053e-03  1.273141e-02
## PC.ae.C38.2_T0    -3.518049e-02  5.861955e-02 -6.408075e-02  3.593753e-02
## PC.ae.C38.3_T0    -4.089493e-02  5.243691e-02 -5.363895e-02  5.026145e-02
## PC.ae.C38.4_T0    -4.569485e-02  2.625039e-03 -2.448249e-02  2.056411e-02
## PC.ae.C38.5_T0    -3.192526e-02 -2.723012e-02 -1.504464e-02  2.332015e-03
## PC.ae.C38.6_T0    -4.613645e-02 -2.173110e-02 -5.003642e-03  1.414507e-02
## PC.ae.C40.1_T0    -5.084815e-02  2.284226e-02 -2.106949e-02  1.964880e-02
## PC.ae.C40.2_T0    -4.710051e-02  3.631939e-02 -3.784293e-02  2.692484e-02
## PC.ae.C40.3_T0    -4.020022e-02  5.202573e-02 -5.975111e-02  4.330442e-02
## PC.ae.C40.4_T0    -4.713499e-02  3.459666e-02 -4.848859e-02  2.895913e-02
## PC.ae.C40.5_T0    -4.608866e-02  4.094891e-02 -4.734619e-02  3.106280e-02
## PC.ae.C40.6_T0    -5.133905e-02 -7.497071e-03  4.333479e-05  7.503292e-03
## PC.ae.C42.1_T0    -5.172954e-02  1.700410e-02 -1.623628e-02  1.361134e-02
## PC.ae.C42.2_T0    -5.214331e-02  1.293312e-02 -1.249491e-02  1.188298e-02
## PC.ae.C42.3_T0    -5.140818e-02  1.829603e-02 -1.933481e-02  1.482275e-02
## PC.ae.C42.4_T0    -5.233265e-02  5.381443e-03 -1.570495e-02  9.153817e-03
## PC.ae.C42.5_T0    -5.075374e-02  1.856278e-02 -2.889258e-02  1.420372e-02
## PC.ae.C44.3_T0    -5.262260e-02  2.564179e-03 -4.501264e-03  6.423447e-03
## PC.ae.C44.4_T0    -5.264653e-02 -3.518964e-03 -8.844004e-04  3.910610e-03
## PC.ae.C44.5_T0    -5.078459e-02 -1.029710e-02  2.150019e-03 -1.480206e-03
## PC.ae.C44.6_T0    -5.167694e-02 -1.145469e-02 -1.209864e-03 -4.265336e-04
## SM..OH..C14.1_T0  -4.928159e-02 -1.530486e-02  9.313234e-03 -5.387356e-03
## SM..OH..C16.1_T0  -5.181957e-02 -8.689912e-03  1.020446e-02  1.710025e-03
## SM..OH..C22.1_T0  -3.615453e-02 -4.026414e-02  6.899994e-03  1.878689e-02
## SM..OH..C22.2_T0  -4.666995e-02  3.342502e-03 -1.296481e-02  1.391046e-02
## SM..OH..C24.1_T0  -5.226009e-02 -1.048512e-02  8.167850e-03  2.521347e-03
## SM.C16.0_T0       -7.828120e-03 -8.261959e-03 -3.558635e-03 -1.574621e-02
## SM.C16.1_T0       -3.170526e-02 -2.404167e-02 -1.615961e-02 -1.583856e-02
## SM.C18.0_T0       -2.901498e-02  1.082833e-02  1.581796e-02  2.361674e-03
## SM.C18.1_T0       -3.905315e-02 -3.637680e-03  8.261195e-03 -6.774493e-03
## SM.C20.2_T0       -5.245883e-02 -9.913957e-03  6.340898e-03  1.655250e-03
## SM.C24.0_T0       -3.504443e-02 -1.304466e-02 -3.389091e-02  1.930640e-02
## SM.C24.1_T0       -1.898667e-02  1.945600e-02  5.773657e-03  3.296389e-03
## MEDDM_T2          -5.245502e-02 -9.564885e-03  6.632371e-03  1.080576e-03
## MEDCOL_T2         -5.245502e-02 -9.564885e-03  6.632371e-03  1.080576e-03
## MEDINF_T2         -5.211366e-02 -1.071897e-02  8.022690e-03  4.077391e-03
## MEDHTA_T2         -5.191703e-02 -6.650130e-03  4.399277e-04  8.783626e-03
## GLU_T2             3.825544e-02  4.252139e-03  8.247871e-03  6.010433e-03
## INS_T2            -4.434399e-04 -1.904866e-02  1.892014e-02 -5.602655e-02
## HOMA_T2           -3.988365e-02 -1.687539e-02  1.363804e-02 -2.900605e-02
## HBA1C_T2          -4.792830e-02 -1.739073e-02  2.556816e-02 -3.765267e-03
## HBA1C.mmol.mol_T2  3.171862e-02 -1.119653e-02  5.174481e-02 -1.201423e-02
## PESO_T2            3.380214e-02 -1.080327e-02 -2.174437e-02 -3.614014e-02
## bmi_T2             3.172695e-02 -1.218128e-02 -2.219040e-02 -1.703664e-02
## CC_T2             -5.216416e-02 -9.795423e-03  8.209750e-03  2.364884e-03
## CINT_T2            4.225017e-02 -1.881668e-03 -4.082745e-03 -4.780645e-03
## CAD_T2             4.179569e-02 -1.463169e-02 -1.059582e-02 -2.620972e-02
## TAD_T2             4.150739e-02  7.100272e-03 -2.455751e-02  2.022245e-02
## TAS_T2             4.103215e-02  8.194423e-03 -1.866632e-02  1.211508e-03
## TG_T2              2.816995e-02 -5.140429e-03  2.624929e-02  8.348114e-03
## COL_T2             3.435067e-02 -1.191990e-02  5.950666e-02  3.593478e-03
## LDL_T2             3.493637e-02  6.368421e-04  5.580306e-02  1.864162e-02
## HDL_T2             1.345175e-02 -2.688160e-02  6.069721e-02 -3.438750e-03
## VLDL_T2            9.435087e-03 -2.811919e-02  3.547613e-02 -1.640362e-02
## PCR_T2            -1.412898e-02 -7.153529e-04  4.185992e-02 -2.697978e-02
## LEP_T2             1.146354e-02 -1.097647e-02  1.987033e-02  2.800129e-03
## ADIPO_T2          -9.355925e-03  1.016337e-03 -1.348928e-02 -1.676050e-02
## GOT_T2             2.360281e-03 -4.586665e-02  1.356174e-02  1.720447e-02
## GPT_T2             7.162270e-03 -2.884920e-02 -5.487717e-03  1.160603e-02
## GGT_T2             7.795501e-03 -2.681696e-02  2.554680e-02  1.852152e-02
## URICO_T2          -3.060967e-02 -2.809284e-02  2.956216e-03 -3.039250e-02
## CREAT_T2          -5.200608e-02 -1.218551e-02  7.035255e-03 -3.953076e-03
## UREA_T2            1.408107e-02  1.329286e-02  7.416350e-02 -2.894384e-02
## HIERRO_T2          1.517783e-02 -1.184607e-02  1.936847e-02  6.521345e-02
## TRANSF_T2          4.199475e-02 -1.246983e-02  2.440201e-02  2.761878e-03
## FERR_T2            7.675456e-03  1.469931e-02 -8.725266e-03 -1.736711e-02
## Ile_T2            -8.621274e-03  5.497743e-02 -2.719281e-03 -1.001336e-01
## Leu_T2            -7.991628e-03  5.891425e-02  4.834765e-04 -1.001346e-01
## Val_T2            -1.093656e-02  6.777186e-02  1.628445e-02 -1.015320e-01
## Ala_T2            -1.674712e-02  7.820676e-02  3.684546e-02 -5.876309e-02
## Pro_T2            -1.612979e-02  6.755335e-02  1.536146e-02 -8.844213e-02
## Gly_T2            -5.530842e-03  3.553334e-02  4.204593e-02 -7.628765e-02
## Ser_T2            -3.100467e-03  4.105752e-02  2.107735e-02 -8.835778e-02
## Trp_T2            -2.766754e-03  6.757765e-02  7.508522e-02 -8.954113e-02
## Phe_T2            -5.692661e-03  6.578627e-02  2.704765e-02 -9.437132e-02
## Met_T2            -1.747946e-02  3.089153e-03  4.662582e-02 -1.477892e-02
## Orn_T2            -3.148348e-03  4.774206e-02  3.655536e-02 -7.391611e-02
## Arg_T2            -8.224978e-03  9.950650e-02  5.251903e-02 -3.832805e-02
## His_T2            -1.376341e-02  9.003043e-02  2.209472e-02 -8.717891e-02
## Asn_T2            -2.652617e-02  6.025220e-02  6.064235e-02 -7.983231e-02
## Asp_T2            -9.997523e-04  3.315654e-02  3.544431e-02 -6.710315e-03
## Glu_T2             7.175733e-03  6.425496e-02 -7.479546e-02  3.022789e-02
## Gln_T2            -1.947893e-02  3.329075e-02  8.014939e-02 -7.136711e-02
## Cit_T2            -2.384681e-02  6.593545e-02  5.819803e-02 -5.666937e-02
## Tyr_T2            -1.792655e-02  7.871440e-02  4.156426e-02 -6.984888e-02
## Thr_T2            -1.433721e-02  3.885229e-02  2.722568e-02 -8.101006e-02
## Lys_T2            -6.023937e-03  7.755619e-02  4.519433e-02 -8.510239e-02
## Creatinine_T2     -7.893733e-03  6.571092e-02  3.904550e-02 -8.615072e-02
## Kynurenine_T2     -5.067728e-02  4.045360e-03  2.062023e-02 -2.315684e-02
## Putrescine_T2      3.431822e-03  2.780524e-02 -1.475363e-02  9.083907e-03
## Sarcosine_T2      -2.618470e-02  3.965990e-02  4.400402e-02 -3.359136e-02
## Serotonin_T2      -1.023620e-02  9.753314e-03 -1.196136e-02 -3.510861e-02
## Taurine_T2        -1.174743e-02  3.227001e-02  9.268447e-03 -3.186203e-03
## SDMA_T2           -5.156382e-02  1.879322e-03  1.290757e-02 -1.335975e-02
## C0_T2             -1.308114e-02  7.750648e-02  4.646985e-02 -1.763247e-02
## C2_T2             -3.077317e-02 -1.270500e-02  1.518447e-04 -2.498897e-02
## C3.OH_T2          -5.246289e-02 -8.721361e-03  7.433831e-03 -4.104634e-04
## C6..C4.1.DC._T2   -8.794011e-05  1.910149e-02 -3.701148e-02  7.061459e-02
## C5.DC..C6.OH._T2  -3.966257e-02 -7.223369e-05  1.488706e-02  2.432386e-02
## C7.DC_T2          -3.945212e-02 -1.980068e-02  2.891609e-02 -2.036034e-02
## C8_T2             -5.247319e-02 -5.835348e-03  9.043459e-03 -1.731781e-03
## C10_T2            -5.246485e-02 -5.304002e-03  8.694260e-03 -3.987744e-03
## C10.1_T2          -5.247819e-02 -8.349250e-03  6.843062e-03 -1.389674e-03
## C10.2_T2          -5.247311e-02 -8.721554e-03  8.374141e-03  8.508383e-05
## C14.1_T2          -5.246604e-02 -8.142849e-03  7.353581e-03  1.867183e-04
## C14.2_T2          -5.244983e-02 -8.934934e-03  7.540346e-03  5.834426e-04
## C16.1_T2          -5.246639e-02 -8.892285e-03  7.453149e-03  9.577030e-04
## C16.2_T2          -5.246115e-02 -9.330009e-03  6.968043e-03  1.079576e-03
## C16.2.OH_T2       -5.246307e-02 -9.292363e-03  6.853309e-03  1.052735e-03
## C18.1_T2          -5.247788e-02 -8.059194e-03  7.173419e-03 -1.154825e-03
## C18.1.OH_T2       -5.245963e-02 -9.360578e-03  7.095768e-03  9.061943e-04
## C18.2_T2          -5.244010e-02 -9.203304e-03  7.137599e-03  3.176886e-04
## lysoPC.a.C14.0_T2 -2.281826e-02 -2.099876e-02  4.869040e-02 -6.003401e-02
## lysoPC.a.C16.0_T2  3.493555e-03  7.448962e-02  1.829048e-02 -6.285216e-02
## lysoPC.a.C16.1_T2 -4.670242e-02  2.390311e-02  2.526679e-02 -3.617971e-02
## lysoPC.a.C17.0_T2 -5.072213e-02  1.749478e-02  1.964668e-02 -1.388903e-02
## lysoPC.a.C18.0_T2 -5.873949e-03  9.003806e-02  4.289960e-02 -3.330789e-02
## lysoPC.a.C18.1_T2 -7.168029e-03  6.562473e-02  5.350483e-02 -8.218161e-02
## lysoPC.a.C18.2_T2 -1.281283e-02  5.720073e-02  6.436753e-02 -6.609383e-02
## lysoPC.a.C20.3_T2 -4.856328e-02  2.413333e-02  2.823329e-02 -1.929142e-02
## lysoPC.a.C20.4_T2 -3.083156e-02  3.708094e-02  2.702869e-02 -6.382399e-02
## lysoPC.a.C24.0_T2 -5.250876e-02 -5.785631e-03  7.645641e-03  8.490239e-04
## lysoPC.a.C26.0_T2 -3.694677e-02 -1.823682e-03  8.127999e-03 -2.731974e-02
## lysoPC.a.C26.1_T2 -5.242601e-02 -8.338033e-03  6.106086e-03 -1.056458e-03
## lysoPC.a.C28.0_T2 -2.936705e-02  1.280549e-02  1.984245e-02 -3.555226e-02
## lysoPC.a.C28.1_T2 -5.241746e-02 -4.941967e-03  6.137211e-03 -8.752074e-04
## PC.aa.C24.0_T2    -1.427309e-02 -3.239714e-02  2.729680e-02 -2.494807e-02
## PC.aa.C28.1_T2    -5.132681e-02  9.440831e-03  3.099406e-02 -1.031314e-02
## PC.aa.C30.0_T2    -5.202883e-02 -1.455034e-03  1.700220e-02 -8.123360e-03
## PC.aa.C32.0_T2    -3.869823e-02  2.687094e-02  5.608107e-02 -5.442115e-02
## PC.aa.C32.1_T2    -3.876949e-02  3.663324e-02  3.865157e-02 -3.515520e-02
## PC.aa.C32.3_T2    -5.253778e-02 -7.642949e-03  6.702165e-03 -4.443329e-04
## PC.aa.C34.1_T2    -6.871676e-03  6.605999e-02  9.276728e-02 -7.690553e-02
## PC.aa.C34.2_T2    -2.109368e-02  6.180995e-02  9.372387e-02 -4.502574e-02
## PC.aa.C34.3_T2    -3.948838e-02  4.385576e-02  5.840761e-02 -2.567210e-02
## PC.aa.C34.4_T2    -5.250617e-02 -4.972344e-03  1.066010e-02 -1.586721e-03
## PC.aa.C36.0_T2    -5.175205e-02  6.067581e-03  7.172530e-03 -6.574652e-03
## PC.aa.C36.1_T2    -2.360321e-02  8.036915e-02  7.265451e-02 -3.386197e-02
## PC.aa.C36.2_T2    -1.459649e-02  7.477894e-02  9.525628e-02 -1.698838e-02
## PC.aa.C36.3_T2    -1.460511e-02  7.605173e-02  8.745500e-02 -3.869726e-02
## PC.aa.C36.4_T2    -2.018011e-02  3.026035e-02  5.029445e-02 -5.499788e-02
## PC.aa.C36.5_T2    -2.966238e-02  3.767907e-02  4.615501e-02 -4.347601e-02
## PC.aa.C38.0_T2    -5.023731e-02  2.264437e-02  2.931214e-02 -1.909040e-02
## PC.aa.C38.1_T2    -4.530134e-02  2.682410e-02 -2.860314e-04 -2.944812e-02
## PC.aa.C38.3_T2    -2.349020e-02  8.168681e-02  7.646186e-02 -2.231953e-02
## PC.aa.C38.4_T2    -1.962151e-02  6.048277e-02  8.261177e-02 -5.319342e-02
## PC.aa.C38.5_T2    -2.422760e-02  5.609569e-02  8.694400e-02 -6.374079e-02
## PC.aa.C38.6_T2    -1.405830e-02  4.953124e-02  6.309218e-02 -3.780808e-02
## PC.aa.C40.1_T2    -2.775708e-02  3.940623e-02  7.435345e-03 -5.730204e-02
## PC.aa.C40.2_T2    -5.042860e-02  6.634111e-03 -1.657985e-02  7.106866e-03
## PC.aa.C40.3_T2    -5.124411e-02  4.023766e-03 -5.621997e-03 -1.139779e-03
## PC.aa.C40.4_T2    -5.049400e-02  2.448560e-02  1.043348e-02 -7.141418e-03
## PC.aa.C40.5_T2    -4.539757e-02  3.198962e-02  5.355546e-02 -2.436583e-02
## PC.aa.C40.6_T2    -2.352882e-02  6.759138e-02  6.843537e-02 -2.036261e-02
## PC.aa.C42.0_T2    -5.253554e-02 -3.916966e-03  5.710044e-03 -2.719226e-03
## PC.aa.C42.1_T2    -5.252381e-02 -5.140283e-03  5.328132e-03 -1.722765e-03
## PC.aa.C42.2_T2    -5.233557e-02 -2.056739e-03 -3.032401e-03  9.581801e-04
## PC.aa.C42.4_T2    -5.248732e-02 -2.398640e-03 -3.353148e-03  4.047450e-03
## PC.aa.C42.5_T2    -5.260377e-02 -4.255415e-03  4.630732e-03  2.678030e-04
## PC.aa.C42.6_T2    -4.149299e-02 -7.351144e-03  2.247671e-02 -1.793776e-02
## PC.ae.C30.0_T2    -3.866764e-02  3.953976e-03  1.315170e-02 -3.710400e-02
## PC.ae.C32.1_T2    -5.158453e-02  6.287398e-03  2.350916e-02 -1.888153e-02
## PC.ae.C32.2_T2    -5.256756e-02 -3.948619e-03  1.068639e-02 -4.495941e-03
## PC.ae.C34.0_T2    -5.254033e-02 -3.562469e-03  1.103251e-02 -1.613118e-03
## PC.ae.C34.1_T2    -4.645693e-02  3.031314e-02  4.895663e-02 -3.711287e-02
## PC.ae.C34.2_T2    -4.617194e-02  3.563224e-02  5.082014e-02 -3.033178e-02
## PC.ae.C34.3_T2    -4.844283e-02  2.431023e-02  4.018361e-02 -1.851495e-02
## PC.ae.C36.0_T2    -5.258760e-02  3.198468e-03  7.374210e-03 -5.493374e-03
## PC.ae.C36.1_T2    -3.117258e-02  4.693675e-02 -3.237397e-02  2.902262e-03
## PC.ae.C36.2_T2    -4.512749e-02  3.938198e-02  4.617977e-02 -2.463510e-02
## PC.ae.C36.3_T2    -5.032515e-02  1.799711e-02  3.413767e-02 -1.825086e-02
## PC.ae.C36.4_T2    -4.494408e-02  3.281381e-02  5.986622e-02 -4.009632e-02
## PC.ae.C36.5_T2    -4.560357e-02  3.248087e-02  5.238353e-02 -3.456805e-02
## PC.ae.C38.0_T2    -5.193794e-02  8.088385e-03  1.926391e-02 -7.537202e-03
## PC.ae.C38.2_T2    -4.133954e-02  3.041475e-02 -3.077215e-02  1.035068e-02
## PC.ae.C38.3_T2    -3.854888e-02  3.658070e-02 -4.625893e-02  1.518008e-02
## PC.ae.C38.4_T2    -4.751978e-02  3.432325e-02  4.018823e-02 -3.478686e-02
## PC.ae.C38.5_T2    -4.018721e-02  3.833141e-02  6.642050e-02 -5.865205e-02
## PC.ae.C38.6_T2    -4.949739e-02  2.061775e-02  4.156293e-02 -2.144402e-02
## PC.ae.C40.1_T2    -5.075761e-02  1.149852e-02 -2.444890e-03 -3.679518e-03
## PC.ae.C40.2_T2    -5.148151e-02  1.317231e-02  1.771201e-03 -1.264436e-03
## PC.ae.C40.3_T2    -4.283186e-02  2.643150e-02 -4.399597e-02  1.635151e-02
## PC.ae.C40.4_T2    -4.962281e-02  2.384091e-02 -1.290434e-02 -5.914266e-03
## PC.ae.C40.5_T2    -4.731579e-02  3.100539e-02 -3.163526e-02  1.496497e-03
## PC.ae.C40.6_T2    -5.135826e-02  1.550029e-02  2.686007e-02 -1.532806e-02
## PC.ae.C42.1_T2    -5.189516e-02  1.142358e-03 -4.632406e-03  2.442960e-03
## PC.ae.C42.2_T2    -5.205024e-02  3.838136e-04  6.813092e-04 -2.497777e-03
## PC.ae.C42.3_T2    -5.176138e-02  6.231921e-03 -6.203187e-03  5.002887e-04
## PC.ae.C42.4_T2    -5.244812e-02  1.292784e-03  6.611616e-03 -3.296204e-03
## PC.ae.C42.5_T2    -5.161280e-02  1.297242e-02  2.214389e-03 -1.455270e-02
## PC.ae.C44.3_T2    -4.360104e-02  4.895102e-03  2.906923e-02  1.629672e-02
## PC.ae.C44.4_T2    -5.251256e-02 -5.460471e-03  6.536077e-03 -1.266908e-03
## PC.ae.C44.5_T2    -5.106780e-02  6.549883e-04  2.490225e-02 -2.180662e-02
## PC.ae.C44.6_T2    -5.192468e-02 -4.793165e-03  1.721883e-02 -1.264488e-02
## SM..OH..C14.1_T2  -4.880184e-02  1.826323e-02  4.003102e-02 -1.380669e-02
## SM..OH..C16.1_T2  -5.176974e-02  5.650898e-03  2.461918e-02 -1.938129e-03
## SM..OH..C22.1_T2  -4.818457e-02  3.029608e-02  4.304018e-02 -3.241965e-03
## SM..OH..C22.2_T2  -4.752607e-02  3.605125e-02  3.492114e-02 -9.298929e-03
## SM..OH..C24.1_T2  -5.255810e-02 -3.864650e-03  1.121992e-02  1.417137e-04
## SM.C16.0_T2       -1.835175e-02  6.548734e-02  9.266550e-02 -2.850688e-02
## SM.C16.1_T2       -3.935709e-02  3.352410e-02  4.735321e-02 -2.714570e-02
## SM.C18.0_T2       -2.653149e-02  3.169499e-02  6.981412e-02  3.677801e-03
## SM.C18.1_T2       -3.952526e-02  1.579564e-02  4.474842e-02 -9.096202e-03
## SM.C20.2_T2       -5.248856e-02 -8.014355e-03  8.616849e-03  2.762188e-05
## SM.C24.0_T2       -4.357222e-02  4.788717e-02  4.456885e-02 -4.712070e-03
## SM.C24.1_T2       -2.191563e-02  6.491029e-02  8.093587e-02 -2.428401e-02
## MEDDM_T4          -5.232131e-02 -9.587091e-03  7.383240e-03  9.461683e-04
## MEDCOL_T4         -5.233223e-02 -8.672076e-03  8.971278e-03  1.229109e-03
## MEDINF_T4         -5.225489e-02 -1.098214e-02  6.806316e-03  3.441130e-03
## MEDHTA_T4         -5.196640e-02 -4.783872e-03  3.883764e-03  9.995554e-03
## GLU_T4             3.776587e-02  9.708867e-03 -5.493337e-03  1.930741e-02
## INS_T4            -8.057575e-03 -1.788429e-02  2.241292e-02 -8.746490e-03
## HOMA_T4           -4.833630e-02 -1.115173e-02  9.878051e-03  3.709219e-03
## HBA1C_T4          -4.735918e-02 -1.419374e-02  2.491052e-02 -2.095342e-03
## HBA1C.mmol.mol_T4  3.326820e-02  2.034290e-03  4.200954e-02 -4.767790e-03
## PESO_T4            3.288495e-02 -8.905267e-03 -2.403978e-02 -4.005446e-02
## bmi_T4             3.094881e-02 -1.048555e-02 -2.612189e-02 -2.319682e-02
## CC_T4             -5.215970e-02 -1.286902e-02  5.244644e-03 -1.417420e-03
## CINT_T4            4.279097e-02 -2.547964e-03 -8.785329e-03 -1.697358e-02
## CAD_T4             3.820527e-02  1.988881e-03  6.380656e-03 -1.054119e-02
## TAD_T4             3.888406e-02 -2.264666e-03  4.187906e-02  7.651832e-03
## TAS_T4             4.239813e-02  5.360805e-03  4.200986e-02 -1.453473e-02
## TG_T4              2.759201e-02 -1.336125e-02  3.672854e-03  5.090264e-02
## COL_T4             3.621061e-02 -8.279696e-03  7.623956e-02 -7.160270e-04
## LDL_T4             3.831689e-02  8.833033e-03  5.682105e-02  1.894601e-02
## HDL_T4             1.453665e-02 -1.994897e-02  6.643885e-02 -2.669485e-02
## VLDL_T4            9.870018e-03 -4.033020e-02  1.802995e-02  5.564629e-02
## PCR_T4            -2.166929e-02  1.217278e-03  2.833520e-02 -2.946358e-02
## LEP_T4             1.455570e-02 -1.568257e-02  2.964047e-02 -6.557642e-03
## ADIPO_T4          -4.504446e-03  1.127687e-02 -3.303355e-02 -2.535030e-02
## GOT_T4            -5.335540e-03 -2.610513e-02 -1.364143e-02  2.050602e-02
## GPT_T4             3.887932e-03 -2.283927e-02 -3.072336e-02  4.906735e-02
## GGT_T4             3.954245e-03  4.308871e-03  1.292712e-02  1.266444e-03
## URICO_T4          -4.156842e-02 -2.498072e-02  2.054556e-02  1.741022e-02
## CREAT_T4          -5.211554e-02 -1.083001e-02  5.202121e-03 -1.823182e-03
## UREA_T4            1.689411e-02  1.411641e-02 -1.529797e-02  3.072658e-02
## HIERRO_T4          4.260482e-03 -2.449553e-02  1.241037e-02  4.234017e-02
## TRANSF_T4          3.678199e-02 -7.980235e-03  6.058152e-02  1.680610e-03
## FERR_T4            1.079934e-02  1.832551e-02 -3.696757e-02  8.470054e-03
## Ile_T4             9.262907e-03 -8.640029e-02 -4.576903e-02 -4.984219e-02
## Leu_T4             9.422412e-03 -8.796663e-02 -5.678239e-02 -7.056775e-02
## Val_T4             1.001374e-02 -8.727427e-02 -5.667147e-02 -8.636508e-02
## Ala_T4             1.726081e-02 -9.022227e-02 -5.553461e-02 -3.481182e-02
## Pro_T4             1.140462e-02 -6.154606e-02 -6.179894e-02 -7.409421e-02
## Gly_T4             5.556011e-03 -7.761374e-02 -3.371671e-03 -7.567848e-02
## Ser_T4             1.463329e-02 -3.311877e-02 -3.267483e-03 -2.855353e-02
## Trp_T4            -1.381675e-03 -9.454777e-02 -3.107555e-02 -8.216936e-02
## Phe_T4             5.788309e-03 -7.585191e-02 -6.444177e-02 -9.993741e-02
## Met_T4            -1.699207e-02 -6.642533e-02  4.589468e-02 -8.793842e-02
## Orn_T4            -2.300997e-03 -8.507586e-02 -3.841970e-02 -7.731444e-02
## Arg_T4             1.727422e-02 -8.035830e-02 -5.833876e-02 -5.863482e-02
## His_T4             7.593302e-03 -8.450097e-02 -7.253802e-02 -7.107802e-02
## Asn_T4            -3.936490e-03 -1.044768e-01 -1.519229e-02 -8.279319e-02
## Asp_T4            -3.282301e-03 -2.824834e-02 -6.080712e-02 -1.565711e-02
## Glu_T4             2.061895e-02  1.539095e-02 -1.058520e-01  5.156662e-02
## Gln_T4             1.303804e-02 -1.050770e-02  5.064413e-02  4.448180e-02
## Cit_T4            -6.288421e-03 -9.584785e-02 -3.430173e-02 -6.596955e-02
## Tyr_T4             1.554605e-03 -8.454654e-02 -4.993335e-02 -8.158786e-02
## Thr_T4             4.983106e-03 -8.900770e-02  2.722186e-03 -7.678495e-02
## Lys_T4             1.420386e-02 -5.292446e-02  1.299039e-02 -2.968199e-02
## Creatinine_T4      7.388703e-03 -8.833154e-02 -5.368672e-02 -5.931448e-02
## Kynurenine_T4     -1.549081e-02 -5.617529e-03 -3.994171e-02 -5.408187e-02
## Putrescine_T4     -4.081949e-03 -1.353443e-02  2.323255e-02  2.264845e-03
## Sarcosine_T4      -2.423799e-02 -3.485859e-02 -8.979389e-03  1.408779e-02
## Serotonin_T4      -1.100873e-02  7.112118e-03 -9.217869e-03 -3.478700e-02
## Taurine_T4         1.222143e-02  3.682083e-02  5.409716e-02  1.939982e-02
## SDMA_T4           -5.133143e-02 -2.778403e-02  3.129862e-04 -1.014630e-02
## C0_T4             -1.577593e-03 -8.812115e-02 -6.511264e-02 -6.111451e-02
## C2_T4             -2.191465e-02 -8.727889e-02  1.952410e-02 -4.392680e-03
## C3.OH_T4          -5.240269e-02 -9.192554e-03  6.613897e-03 -5.927405e-04
## C6..C4.1.DC._T4    3.086552e-03  3.624466e-02  3.066182e-02  3.903211e-02
## C5.DC..C6.OH._T4  -3.776637e-02  2.286194e-03 -2.741385e-02 -3.617937e-02
## C7.DC_T4          -3.918263e-02 -1.357590e-02 -1.525952e-02  1.418613e-03
## C8_T4             -5.231163e-02 -1.044477e-02  6.015725e-03 -2.244538e-03
## C10_T4            -5.228081e-02 -1.251930e-02  4.201056e-03 -2.919374e-03
## C10.1_T4          -5.238288e-02 -1.119416e-02  5.391740e-03  2.614087e-05
## C10.2_T4          -5.242964e-02 -9.721547e-03  7.304200e-03  2.644183e-04
## C14.1_T4          -5.239423e-02 -1.100754e-02  6.403639e-03 -5.615208e-04
## C14.2_T4          -5.242313e-02 -1.008755e-02  6.660763e-03  4.522273e-04
## C16.1_T4          -4.571691e-02 -1.086825e-02  8.704063e-05  6.301137e-03
## C16.2_T4          -5.244948e-02 -9.609665e-03  6.737918e-03  1.135550e-03
## C16.2.OH_T4       -4.582815e-02 -1.059955e-02  1.470787e-05  6.660216e-03
## C18.1_T4          -5.239694e-02 -1.156639e-02  6.212138e-03 -7.840861e-04
## C18.1.OH_T4       -5.244969e-02 -9.540861e-03  6.859970e-03  9.155320e-04
## C18.2_T4          -5.243200e-02 -1.009875e-02  6.686196e-03  5.992285e-04
## lysoPC.a.C16.0_T4  1.713196e-02 -7.138737e-02 -8.209270e-02 -2.393707e-02
## lysoPC.a.C16.1_T4 -4.027309e-02 -4.251549e-02 -5.491598e-02 -2.199679e-02
## lysoPC.a.C17.0_T4 -4.928457e-02 -2.815814e-02 -2.395334e-02 -1.046205e-02
## lysoPC.a.C18.0_T4  1.413599e-02 -5.238706e-02 -8.900639e-02 -1.301527e-02
## lysoPC.a.C18.1_T4  5.038105e-03 -8.082093e-02 -6.025839e-02 -4.679781e-02
## lysoPC.a.C18.2_T4 -1.491493e-03 -9.588730e-02 -5.134648e-02 -4.717478e-02
## lysoPC.a.C20.3_T4 -4.884794e-02 -3.296966e-02 -2.043077e-02 -3.217678e-03
## lysoPC.a.C20.4_T4 -1.417880e-02 -8.274569e-02 -3.412700e-02 -2.518016e-02
## lysoPC.a.C24.0_T4 -5.245141e-02 -8.250638e-03  3.619021e-03  1.066094e-03
## lysoPC.a.C26.0_T4 -3.856085e-02 -1.341375e-02 -1.743713e-02 -1.873343e-02
## lysoPC.a.C26.1_T4 -5.247117e-02 -9.099357e-03  8.160507e-04  8.595927e-04
## lysoPC.a.C28.0_T4 -3.516106e-02 -1.816111e-02 -4.611272e-02 -2.461032e-02
## lysoPC.a.C28.1_T4 -5.246483e-02 -9.063869e-03 -1.807198e-03  3.881281e-03
## PC.aa.C24.0_T4    -3.164774e-02 -9.324753e-03 -2.704195e-02 -1.317167e-02
## PC.aa.C28.1_T4    -5.022019e-02 -3.179324e-02  5.546469e-03 -1.914702e-02
## PC.aa.C30.0_T4    -5.100076e-02 -2.698390e-02  4.912533e-03 -1.292185e-03
## PC.aa.C32.0_T4    -1.647288e-02 -1.003664e-01 -1.015577e-02 -4.807823e-02
## PC.aa.C32.1_T4    -1.892055e-02 -5.558125e-02 -3.809191e-02 -2.862147e-02
## PC.aa.C32.3_T4    -5.245559e-02 -1.173329e-02  5.160321e-03  3.379655e-04
## PC.aa.C34.1_T4     1.409626e-02 -9.104317e-02 -2.358959e-02 -4.504567e-02
## PC.aa.C34.2_T4     7.209987e-03 -1.071653e-01 -1.273804e-02 -3.102972e-02
## PC.aa.C34.3_T4    -2.922942e-02 -6.244900e-02 -3.840478e-02 -1.984401e-02
## PC.aa.C34.4_T4    -5.232296e-02 -1.387201e-02  4.576163e-03  2.359843e-04
## PC.aa.C36.0_T4    -5.173241e-02 -1.899562e-02 -8.811460e-03  2.920794e-03
## PC.aa.C36.1_T4    -1.032037e-02 -7.115917e-02 -1.124918e-02 -3.905434e-02
## PC.aa.C36.2_T4     7.555204e-03 -9.117929e-02 -9.295991e-03 -4.530973e-02
## PC.aa.C36.3_T4     7.099049e-03 -8.297010e-02 -7.683613e-03 -3.580771e-02
## PC.aa.C36.4_T4     7.730246e-03 -9.962392e-02  1.352704e-02 -2.015163e-02
## PC.aa.C36.5_T4    -2.533029e-02 -6.763111e-02 -2.385244e-02 -3.456147e-02
## PC.aa.C38.0_T4    -4.772214e-02 -4.203239e-02 -5.801135e-03 -2.038307e-02
## PC.aa.C38.1_T4    -5.116917e-02 -1.275558e-02 -1.823866e-02  1.873576e-02
## PC.aa.C38.3_T4     5.259916e-03 -7.584427e-02 -9.527220e-03 -3.220045e-02
## PC.aa.C38.4_T4     9.180663e-03 -9.531148e-02  8.052211e-03 -4.808785e-02
## PC.aa.C38.5_T4    -4.965751e-04 -1.000333e-01 -1.741344e-03 -6.204222e-02
## PC.aa.C38.6_T4     6.768952e-03 -8.764110e-02 -3.264173e-03 -7.004607e-03
## PC.aa.C40.1_T4    -3.389054e-02 -2.801690e-02 -3.432404e-02 -4.573889e-03
## PC.aa.C40.2_T4    -5.092157e-02  2.877257e-03 -2.541736e-02  2.067328e-02
## PC.aa.C40.3_T4    -5.171111e-02 -4.423233e-03 -1.904176e-02  1.375604e-02
## PC.aa.C40.4_T4    -4.928070e-02 -1.818413e-02 -3.194470e-02  2.931356e-03
## PC.aa.C40.5_T4    -4.256444e-02 -5.996266e-02  1.345227e-03 -2.742795e-02
## PC.aa.C40.6_T4    -3.830424e-03 -8.943352e-02 -1.282754e-03 -1.147365e-02
## PC.aa.C42.0_T4    -5.226782e-02 -1.641383e-02 -2.238445e-03 -4.074328e-04
## PC.aa.C42.1_T4    -5.249195e-02 -1.077104e-02 -8.519061e-04  2.153613e-03
## PC.aa.C42.2_T4    -5.244790e-02 -6.414860e-03 -7.032941e-03  6.514160e-03
## PC.aa.C42.4_T4    -5.236424e-02 -4.784123e-03 -9.218458e-03  8.616250e-03
## PC.aa.C42.5_T4    -5.249389e-02 -1.162755e-02 -5.653181e-04  3.276734e-03
## PC.aa.C42.6_T4    -4.000615e-02 -2.481959e-02 -2.258466e-02 -2.354775e-03
## PC.ae.C30.0_T4    -4.191499e-02 -2.207880e-02  1.030657e-02 -1.402873e-02
## PC.ae.C32.1_T4    -4.939342e-02 -4.074802e-02  1.649122e-03 -2.386045e-02
## PC.ae.C32.2_T4    -5.218699e-02 -1.831028e-02  1.679541e-03 -6.964678e-03
## PC.ae.C34.0_T4    -5.235198e-02 -1.424114e-02  5.960183e-03 -3.558667e-03
## PC.ae.C34.1_T4    -4.061515e-02 -6.791533e-02 -7.813853e-04 -5.040955e-02
## PC.ae.C34.2_T4    -3.655876e-02 -7.488340e-02 -6.960182e-03 -5.563544e-02
## PC.ae.C34.3_T4    -3.940780e-02 -6.814094e-02  2.714868e-03 -3.598939e-02
## PC.ae.C36.0_T4    -5.216797e-02 -1.831788e-02  1.998333e-04 -5.647126e-03
## PC.ae.C36.1_T4    -2.673550e-02  1.030129e-02 -9.677020e-02  2.719704e-02
## PC.ae.C36.2_T4    -3.968251e-02 -6.131523e-02 -2.554263e-02 -2.504375e-02
## PC.ae.C36.3_T4    -4.817349e-02 -4.603808e-02 -2.356109e-03 -2.583440e-02
## PC.ae.C36.4_T4    -3.365439e-02 -7.733988e-02  5.319832e-07 -6.532096e-02
## PC.ae.C36.5_T4    -3.441805e-02 -8.167917e-02  4.396732e-03 -5.025253e-02
## PC.ae.C38.0_T4    -5.107980e-02 -2.705217e-02 -4.754182e-03 -4.389361e-03
## PC.ae.C38.2_T4    -3.251521e-02  2.003178e-02 -8.543100e-02  3.823899e-02
## PC.ae.C38.3_T4    -3.276376e-02  2.145729e-02 -8.128558e-02  5.303645e-02
## PC.ae.C38.4_T4    -4.280554e-02 -5.827199e-02 -5.359582e-03 -3.899559e-02
## PC.ae.C38.5_T4    -2.607104e-02 -8.351648e-02  8.783486e-03 -6.756581e-02
## PC.ae.C38.6_T4    -4.580786e-02 -5.588684e-02  5.973495e-03 -3.165104e-02
## PC.ae.C40.1_T4    -5.151444e-02 -1.217382e-02 -2.108544e-02  1.003652e-02
## PC.ae.C40.2_T4    -5.039888e-02 -7.600454e-03 -2.773796e-02  1.385474e-02
## PC.ae.C40.3_T4    -3.745867e-02  1.955701e-02 -7.309303e-02  4.691796e-02
## PC.ae.C40.4_T4    -4.579107e-02 -5.475700e-03 -5.314290e-02  1.583794e-02
## PC.ae.C40.5_T4    -4.060167e-02 -1.832017e-03 -7.349792e-02  1.551030e-02
## PC.ae.C40.6_T4    -5.003971e-02 -3.815300e-02 -1.241504e-03 -1.623764e-02
## PC.ae.C42.1_T4    -5.215109e-02 -5.778763e-03 -1.236943e-02  1.216057e-02
## PC.ae.C42.2_T4    -5.232789e-02 -7.731871e-03 -9.310328e-03  7.574398e-03
## PC.ae.C42.3_T4    -5.168568e-02 -8.194570e-03 -2.183769e-02  8.086212e-03
## PC.ae.C42.4_T4    -5.212115e-02 -1.336107e-02 -8.742491e-03  6.003850e-04
## PC.ae.C42.5_T4    -4.821479e-02 -3.021840e-02 -3.149769e-02 -1.430080e-02
## PC.ae.C44.3_T4    -5.253276e-02 -6.925788e-03 -2.523453e-03  4.897807e-03
## PC.ae.C44.4_T4    -5.243211e-02 -1.157038e-02  2.064830e-03  8.127635e-04
## PC.ae.C44.5_T4    -4.808206e-02 -4.321302e-02 -2.101124e-03 -2.560206e-02
## PC.ae.C44.6_T4    -5.065478e-02 -3.031522e-02  4.643480e-04 -1.293130e-02
## SM..OH..C14.1_T4  -4.464298e-02 -5.221134e-02  8.126572e-03 -3.452157e-02
## SM..OH..C16.1_T4  -5.067272e-02 -2.882120e-02  9.079541e-03 -8.134989e-03
## SM..OH..C22.1_T4  -4.611094e-02 -4.176324e-02  1.554981e-02 -1.572935e-02
## SM..OH..C22.2_T4  -4.448851e-02 -5.348386e-02 -7.229770e-03 -1.426901e-02
## SM..OH..C24.1_T4  -5.228478e-02 -1.415748e-02  6.742601e-03 -1.739562e-04
## SM.C16.0_T4        1.291397e-02 -1.018592e-01  6.458077e-03 -4.162183e-02
## SM.C16.1_T4       -1.581946e-02 -9.631158e-02 -7.437753e-03 -4.231515e-02
## SM.C18.0_T4       -4.589461e-03 -8.799884e-02  8.513275e-03  1.926188e-02
## SM.C18.1_T4       -2.294203e-02 -8.631346e-02 -3.427442e-03 -1.092838e-02
## SM.C20.2_T4       -5.237725e-02 -1.306412e-02  6.092465e-03  6.583696e-04
## SM.C24.0_T4       -3.860105e-02 -5.500487e-02 -2.059113e-03 -1.005620e-02
## SM.C24.1_T4        1.019777e-02 -9.989735e-02 -7.273003e-03 -6.633316e-03
## MEDDM_T5          -5.150080e-02 -3.237145e-03  3.624385e-03  1.010204e-02
## MEDCOL_T5         -5.150080e-02 -3.237145e-03  3.624385e-03  1.010204e-02
## MEDINF_T5         -5.147425e-02 -4.520952e-03  3.540330e-03  1.237918e-02
## MEDHTA_T5         -5.144547e-02 -3.290546e-03  4.415548e-03  9.942508e-03
## GLU_T5            -4.932356e-03  8.827364e-02  2.392928e-02  2.086465e-02
## INS_T5            -3.656599e-02  3.097675e-02  1.651235e-02  3.040778e-02
## HOMA_T5           -5.044671e-02  5.744586e-03  1.377589e-02  1.311854e-02
## HBA1C_T5          -4.740661e-02 -1.726258e-02  2.114776e-02 -1.609879e-03
## HBA1C.mmol.mol_T5  3.435251e-02 -8.243280e-03  2.939061e-02 -3.154598e-03
## PESO_T5           -2.080252e-02  8.848088e-02 -3.398739e-02 -6.389771e-03
## bmi_T5            -2.237296e-02  9.031373e-02 -3.361876e-02  6.714940e-03
## CC_T5             -5.219480e-02 -1.130866e-02  8.353558e-03  1.394497e-03
## CINT_T5           -2.298862e-02  9.986742e-02 -2.057489e-02  2.146791e-02
## CAD_T5            -1.107638e-02  1.027230e-01 -2.940514e-02  2.045903e-03
## TAD_T5             3.879234e-02  5.728967e-03  2.662768e-02  2.104849e-02
## TAS_T5             4.134639e-02  1.224887e-02  1.332890e-02  2.122096e-03
## TG_T5             -1.296414e-02  5.106110e-02  1.744704e-02  6.915014e-02
## COL_T5             1.030419e-02  3.538364e-02  9.360254e-02  2.797949e-02
## LDL_T5             2.068921e-02  4.370577e-02  6.554792e-02  3.320838e-02
## HDL_T5            -9.409149e-03  7.674480e-03  6.183629e-02  1.216976e-02
## VLDL_T5           -3.165450e-02  3.064036e-02  1.568542e-02  7.712265e-02
## PCR_T5            -3.820377e-02  2.402352e-02  3.775250e-02 -4.537154e-02
## LEP_T5            -2.092006e-02  7.537560e-02  2.583980e-02 -1.449497e-02
## ADIPO_T5          -1.194825e-02  2.956043e-02 -1.952951e-02 -9.008070e-03
## GOT_T5            -2.025115e-02  3.161952e-02 -7.807932e-03  8.795260e-03
## GPT_T5            -1.211157e-02  5.657011e-02 -2.766752e-02  2.687791e-02
## GGT_T5            -3.310877e-02  7.348772e-02 -1.661329e-02  4.534138e-02
## URICO_T5          -4.899134e-02  1.976455e-02  2.344549e-04  2.449636e-02
## CREAT_T5          -5.247049e-02 -4.689248e-03  6.840599e-03 -1.884846e-04
## UREA_T5           -1.447445e-02  6.533065e-02 -1.604312e-02  4.974307e-03
## HIERRO_T5         -4.796012e-03  6.332439e-04  1.148873e-02  7.421884e-02
## TRANSF_T5         -1.355665e-02  6.965061e-02  3.776407e-02  2.406428e-02
## FERR_T5            1.195663e-03  2.637314e-02 -4.554595e-02  3.085219e-02
## Ile_T5             3.465359e-02 -8.079058e-03 -2.817134e-02  5.863541e-02
## Leu_T5             3.353699e-02 -1.673166e-02 -1.775763e-02  4.551440e-02
## Val_T5             3.577992e-02 -1.360018e-02  3.709242e-03  3.393547e-02
## Ala_T5             4.356605e-02  1.599638e-02 -1.211484e-02  6.537560e-02
## Pro_T5             3.821640e-02 -8.080291e-03 -1.398297e-02  2.737739e-02
## Gly_T5             2.963037e-02 -2.137027e-02  3.944158e-02  3.703296e-02
## Ser_T5             3.513482e-02 -3.761597e-02  3.179049e-02  1.723059e-02
## Trp_T5             2.121909e-02 -1.242593e-02  4.457891e-02  5.339619e-02
## Phe_T5             3.252321e-02 -2.805376e-03 -1.502318e-02  4.471480e-02
## Met_T5             1.384154e-02 -4.230277e-02  8.062186e-02  2.833562e-02
## Orn_T5             2.846596e-02 -2.453541e-02  2.363622e-02  4.225131e-02
## Arg_T5             3.627374e-02 -3.391671e-04 -2.278124e-03  9.847268e-02
## His_T5             3.298185e-02 -8.154079e-03 -4.140090e-02  7.439198e-02
## Asn_T5             3.107940e-02 -3.627083e-02  4.541242e-02  4.194208e-02
## Asp_T5             9.369929e-03  1.453723e-02  2.249959e-02  4.561277e-02
## Glu_T5             2.226301e-02  4.292080e-02 -7.259913e-02  6.952453e-02
## Gln_T5             2.810448e-02 -5.990639e-02  5.466750e-02  4.683917e-02
## Cit_T5             2.621963e-02 -7.355723e-03  2.464372e-02  6.534109e-02
## Tyr_T5             3.543152e-02  9.604781e-04  8.252083e-03  5.498797e-02
## Thr_T5             3.183640e-02 -1.746851e-02  7.279472e-02  1.029979e-02
## Lys_T5             4.125049e-02 -6.561489e-03  1.465518e-02  6.663065e-02
## Creatinine_T5      2.401439e-02 -2.828510e-02  3.363679e-02  3.403529e-02
## Kynurenine_T5     -6.222454e-03 -8.007623e-03  9.589713e-02  1.346008e-02
## Putrescine_T5     -9.185678e-03 -3.704751e-03 -3.769871e-02  4.288502e-02
## Sarcosine_T5      -2.136796e-02  1.621620e-02  3.700191e-03  3.974124e-02
## Serotonin_T5      -1.326178e-02  1.282109e-03 -1.678207e-02 -3.395655e-02
## Taurine_T5         2.022184e-02  1.322162e-02  1.453510e-02 -3.155788e-02
## SDMA_T5           -5.184739e-02 -1.465096e-02  1.452524e-02  1.157047e-02
## C0_T5              2.960476e-02  4.178836e-03  2.111815e-03  8.299266e-02
## C2_T5             -2.218936e-02 -4.967117e-02  6.677972e-02  4.401575e-02
## C3.OH_T5          -5.238162e-02 -1.044421e-02  7.088899e-03  8.029096e-05
## C6..C4.1.DC._T5   -3.334221e-03  1.183923e-03 -4.458075e-02  3.625662e-02
## C5.DC..C6.OH._T5  -4.574370e-02 -6.148936e-03 -3.807181e-03 -1.703594e-02
## C7.DC_T5          -4.120378e-02 -2.786588e-02  2.621333e-02 -2.092243e-02
## C8_T5             -5.225193e-02 -1.067114e-02  8.435645e-03  8.035746e-05
## C10_T5            -5.216199e-02 -1.137957e-02  8.743399e-03  1.517650e-03
## C10.1_T5          -4.000612e-02 -1.197213e-02  1.832955e-02  3.550731e-02
## C10.2_T5          -5.239715e-02 -1.026692e-02  7.127743e-03  6.733821e-04
## C14.1_T5          -5.238913e-02 -1.048270e-02  7.702819e-03  1.966301e-03
## C14.2_T5          -5.241707e-02 -9.923341e-03  6.784646e-03  1.245400e-03
## C16.1_T5          -5.243229e-02 -9.892061e-03  6.872788e-03  1.296953e-03
## C16.2_T5          -5.244414e-02 -9.750169e-03  6.708102e-03  1.064722e-03
## C16.2.OH_T5       -4.268832e-02 -1.280140e-02 -3.344134e-02 -3.205222e-02
## C18.1_T5          -5.242291e-02 -1.004155e-02  7.210269e-03  2.320689e-03
## C18.1.OH_T5       -5.244673e-02 -9.784750e-03  6.796257e-03  1.004841e-03
## C18.2_T5          -5.243392e-02 -9.888021e-03  6.550968e-03  1.622239e-03
## lysoPC.a.C16.0_T5  2.907325e-02 -1.432611e-02 -4.024542e-03  1.049269e-01
## lysoPC.a.C16.1_T5 -3.770926e-02 -3.027073e-03 -3.943408e-02  5.920804e-02
## lysoPC.a.C17.0_T5 -4.988898e-02 -1.018307e-02  1.042120e-02  3.926384e-02
## lysoPC.a.C18.0_T5  2.688807e-02  6.407240e-03 -4.838211e-03  1.145931e-01
## lysoPC.a.C18.1_T5  2.054466e-02 -2.087372e-02  2.111059e-03  9.161491e-02
## lysoPC.a.C18.2_T5  1.494636e-02 -3.181746e-02  1.523820e-02  1.036081e-01
## lysoPC.a.C20.3_T5 -4.278276e-02 -1.101158e-02 -2.985152e-03  7.534093e-02
## lysoPC.a.C20.4_T5 -1.554890e-03 -2.765956e-02  9.501379e-03  9.692562e-02
## lysoPC.a.C24.0_T5 -5.240408e-02 -8.990629e-03  5.033681e-03  3.108793e-03
## lysoPC.a.C26.0_T5 -5.242397e-02 -6.845549e-03 -4.610364e-04  8.050022e-03
## lysoPC.a.C26.1_T5 -5.240065e-02 -1.021802e-02  5.164947e-03  5.007766e-03
## lysoPC.a.C28.0_T5 -3.058255e-02 -8.995770e-03  4.522804e-03  7.876446e-02
## lysoPC.a.C28.1_T5 -5.243372e-02 -9.282513e-03  4.969562e-03  6.307637e-03
## PC.aa.C24.0_T5    -2.996863e-02 -4.164895e-03  1.888470e-02  1.128320e-02
## PC.aa.C28.1_T5    -5.049343e-02 -2.076042e-02  2.944869e-02  2.385457e-02
## PC.aa.C30.0_T5    -5.022501e-02 -2.013622e-02  1.900439e-02  2.462978e-02
## PC.aa.C32.0_T5    -1.299253e-02 -6.246764e-02  8.907183e-02  9.105592e-02
## PC.aa.C32.1_T5    -1.865142e-02 -2.706506e-02  1.888486e-02  7.939344e-02
## PC.aa.C32.3_T5    -5.244319e-02 -9.996895e-03  7.662508e-03  2.925786e-03
## PC.aa.C34.1_T5     2.626829e-02 -4.407915e-02  7.721770e-02  9.794823e-02
## PC.aa.C34.2_T5     2.013604e-02 -5.430590e-02  8.325655e-02  1.031700e-01
## PC.aa.C34.3_T5    -2.049242e-02 -3.036288e-02  3.911787e-02  1.015323e-01
## PC.aa.C34.4_T5    -5.226023e-02 -1.091114e-02  7.744382e-03  8.979559e-03
## PC.aa.C36.0_T5    -5.154809e-02 -1.118056e-02  3.369201e-03  2.459519e-02
## PC.aa.C36.1_T5     4.658680e-03 -2.188069e-02  7.480618e-02  1.242558e-01
## PC.aa.C36.2_T5     2.214578e-02 -3.266877e-02  8.478424e-02  1.080345e-01
## PC.aa.C36.3_T5     2.272746e-02 -2.994081e-02  7.403130e-02  1.099153e-01
## PC.aa.C36.4_T5     2.079923e-02 -5.039248e-02  7.343672e-02  8.974764e-02
## PC.aa.C36.5_T5    -2.826087e-02 -2.924563e-02  4.671139e-02  7.374215e-02
## PC.aa.C38.0_T5    -4.741980e-02 -2.308284e-02  2.709394e-02  4.359518e-02
## PC.aa.C38.1_T5    -5.146515e-02 -2.945281e-03  5.442573e-03  1.679289e-02
## PC.aa.C38.3_T5     1.901366e-02 -1.173850e-02  4.177319e-02  1.178720e-01
## PC.aa.C38.4_T5     2.479418e-02 -2.775443e-02  8.306046e-02  9.282048e-02
## PC.aa.C38.5_T5     1.667028e-02 -4.590749e-02  9.941096e-02  8.733492e-02
## PC.aa.C38.6_T5     2.250060e-02 -3.984975e-02  6.314098e-02  1.135098e-01
## PC.aa.C40.1_T5    -3.198230e-02 -1.566270e-02  1.408036e-02  5.864319e-02
## PC.aa.C40.2_T5    -5.171586e-02 -8.661961e-04 -1.559623e-02  1.466316e-02
## PC.aa.C40.3_T5    -5.169293e-02 -3.568410e-03 -9.416695e-03  1.329640e-02
## PC.aa.C40.4_T5    -5.019211e-02 -1.275151e-02  8.257900e-03  3.448146e-02
## PC.aa.C40.5_T5    -4.094825e-02 -2.889005e-02  6.263438e-02  6.649408e-02
## PC.aa.C40.6_T5     1.455528e-02 -2.215147e-02  6.117233e-02  1.346530e-01
## PC.aa.C42.0_T5    -5.231470e-02 -1.156519e-02  6.669088e-03  9.862692e-03
## PC.aa.C42.1_T5    -5.246941e-02 -9.591139e-03  4.616755e-03  5.910429e-03
## PC.aa.C42.2_T5    -5.244764e-02 -6.501827e-03 -2.657050e-03  7.038771e-03
## PC.aa.C42.4_T5    -5.238574e-02 -5.151438e-03 -5.477948e-03  8.607143e-03
## PC.aa.C42.5_T5    -5.243442e-02 -9.774281e-03  3.240068e-03  8.726349e-03
## PC.aa.C42.6_T5    -3.883784e-02  4.446195e-03  2.885925e-02  2.931491e-02
## PC.ae.C30.0_T5    -4.338125e-02  1.230531e-03  3.757069e-02  1.544726e-02
## PC.ae.C32.1_T5    -5.000798e-02 -2.463406e-02  3.016962e-02  2.190687e-02
## PC.ae.C32.2_T5    -5.228321e-02 -1.246613e-02  1.090434e-02  6.976597e-03
## PC.ae.C34.0_T5    -5.230840e-02 -1.059795e-02  1.208706e-02  5.232805e-03
## PC.ae.C34.1_T5    -4.048060e-02 -3.767488e-02  7.322595e-02  5.577031e-02
## PC.ae.C34.2_T5    -3.249940e-02 -4.658514e-02  7.552751e-02  6.816774e-02
## PC.ae.C34.3_T5    -3.650278e-02 -4.556629e-02  5.977278e-02  5.952175e-02
## PC.ae.C36.0_T5    -5.214814e-02 -1.253209e-02  1.143110e-02  1.205451e-02
## PC.ae.C36.1_T5    -3.399604e-02  1.780170e-02 -4.805272e-02  6.258786e-02
## PC.ae.C36.2_T5    -3.698098e-02 -2.696795e-02  5.992963e-02  7.752413e-02
## PC.ae.C36.3_T5    -4.709058e-02 -2.744909e-02  4.481171e-02  3.842484e-02
## PC.ae.C36.4_T5    -3.082485e-02 -5.476116e-02  7.887616e-02  5.879241e-02
## PC.ae.C36.5_T5    -2.920571e-02 -5.754691e-02  7.636102e-02  6.537629e-02
## PC.ae.C38.0_T5    -5.165695e-02 -1.421318e-02  1.269032e-02  2.363743e-02
## PC.ae.C38.2_T5    -3.716498e-02  1.788185e-02 -5.784289e-02  4.351079e-02
## PC.ae.C38.3_T5    -4.081035e-02  2.084427e-02 -4.695902e-02  6.010280e-02
## PC.ae.C38.4_T5    -4.211157e-02 -2.866996e-02  6.975017e-02  5.656605e-02
## PC.ae.C38.5_T5    -1.797039e-02 -5.504358e-02  9.519102e-02  6.293168e-02
## PC.ae.C38.6_T5    -4.478431e-02 -3.529525e-02  5.314466e-02  4.865804e-02
## PC.ae.C40.1_T5    -5.186014e-02 -7.165665e-03 -3.167751e-03  2.450672e-02
## PC.ae.C40.2_T5    -5.085067e-02 -1.608866e-03 -1.202225e-02  3.121778e-02
## PC.ae.C40.3_T5    -4.110564e-02  2.082306e-02 -5.621954e-02  5.430364e-02
## PC.ae.C40.4_T5    -4.847784e-02  2.352035e-03 -1.905042e-02  4.171745e-02
## PC.ae.C40.5_T5    -4.479973e-02  5.846900e-03 -3.249299e-02  5.523492e-02
## PC.ae.C40.6_T5    -5.007202e-02 -2.001413e-02  3.049148e-02  3.288928e-02
## PC.ae.C42.1_T5    -5.233277e-02 -5.129929e-03 -5.171104e-03  1.303470e-02
## PC.ae.C42.2_T5    -5.240686e-02 -5.697950e-03 -1.342449e-03  1.010146e-02
## PC.ae.C42.3_T5    -5.199001e-02 -5.210296e-03 -7.307275e-03  1.701921e-02
## PC.ae.C42.4_T5    -5.214477e-02 -9.002769e-03  2.398404e-03  1.525033e-02
## PC.ae.C42.5_T5    -4.919234e-02 -1.100229e-02 -5.061407e-03  4.178787e-02
## PC.ae.C44.3_T5    -5.249463e-02 -6.823690e-03 -1.539056e-03  6.112403e-03
## PC.ae.C44.4_T5    -5.240055e-02 -9.800095e-03  6.272282e-03  6.023474e-03
## PC.ae.C44.5_T5    -4.952147e-02 -2.504813e-02  2.919331e-02  2.260792e-02
## PC.ae.C44.6_T5    -5.081071e-02 -2.120197e-02  1.897629e-02  1.626352e-02
## SM..OH..C14.1_T5  -4.546559e-02 -2.704088e-02  6.026883e-02  3.922726e-02
## SM..OH..C16.1_T5  -5.123293e-02 -1.555209e-02  2.719542e-02  1.767007e-02
## SM..OH..C22.1_T5  -4.081127e-02 -3.174242e-02  5.776840e-02  4.910790e-02
## SM..OH..C22.2_T5  -4.280667e-02 -2.744135e-02  4.966870e-02  6.182782e-02
## SM..OH..C24.1_T5  -5.225125e-02 -1.193210e-02  1.215401e-02  4.825664e-03
## SM.C16.0_T5        2.511732e-02 -4.307651e-02  9.079469e-02  9.336900e-02
## SM.C16.1_T5       -1.059342e-02 -5.039223e-02  9.530042e-02  7.761307e-02
## SM.C18.0_T5        1.577563e-03 -3.445486e-02  7.254780e-02  1.129948e-01
## SM.C18.1_T5       -2.851238e-02 -3.932298e-02  6.635420e-02  7.695362e-02
## SM.C20.2_T5       -5.234350e-02 -1.104973e-02  8.486420e-03  4.303566e-03
## SM.C24.0_T5       -2.543839e-02 -4.487573e-02  4.899507e-02  9.971798e-02
## SM.C24.1_T5        1.987643e-02 -4.300291e-02  6.967238e-02  1.136367e-01
##                             PC5           PC6           PC7           PC8
## GLU_T0            -1.720638e-02  5.225217e-02 -8.167498e-02 -9.482512e-02
## INS_T0            -4.680565e-03  1.730841e-02 -9.167174e-02 -3.646095e-02
## HOMA_T0           -3.741193e-03  1.957496e-02 -8.456639e-02 -3.776664e-02
## HBA1C_T0          -3.651642e-03 -7.550311e-02  2.605982e-02 -4.682885e-02
## HBA1C.mmol.mol_T0 -7.868349e-03 -9.884411e-02  5.186465e-02 -8.635331e-02
## PESO_T0           -1.571945e-02 -1.853918e-02 -1.015980e-01 -4.935067e-02
## bmi_T0            -1.499417e-02 -2.546247e-03 -7.231073e-02 -8.336802e-02
## CC_T0             -8.783815e-04 -1.672638e-02 -6.702046e-03 -3.477634e-03
## CINT_T0           -9.147539e-03  6.461575e-03 -5.710439e-02 -2.950765e-02
## CAD_T0            -2.201109e-02  4.748038e-03 -2.472878e-02 -8.230949e-02
## TAD_T0             1.245867e-03 -5.554776e-02  3.420465e-02 -1.381334e-01
## TAS_T0            -2.246549e-03 -6.898702e-02  3.331780e-02 -7.178541e-02
## TG_T0              1.198507e-03  1.147710e-01 -2.812192e-02 -1.178921e-01
## COL_T0            -5.145790e-02  6.776599e-02  4.855158e-02 -1.474685e-01
## LDL_T0            -5.645871e-02  5.741456e-02  3.208877e-03 -1.039765e-01
## HDL_T0             9.606825e-03 -2.049912e-02  1.517202e-01 -6.373278e-02
## VLDL_T0            1.300810e-03  1.127417e-01 -2.928555e-02 -1.193238e-01
## PCR_T0            -6.154786e-02  2.831460e-02 -2.763230e-02 -4.876511e-02
## LEP_T0            -2.436914e-02  6.605562e-02 -3.959974e-02 -5.872691e-02
## ADIPO_T0           5.368261e-02 -3.865827e-02  1.314290e-01 -6.910006e-02
## GOT_T0             6.108101e-02  2.095381e-02 -2.327114e-02  2.338151e-02
## GPT_T0             2.777123e-02 -1.406648e-02 -9.987168e-02 -2.821359e-02
## GGT_T0             4.267764e-03  5.452914e-02 -6.165759e-02  1.632076e-02
## URICO_T0          -5.514437e-03 -2.317072e-02 -3.966028e-02 -2.211302e-02
## CREAT_T0          -2.221790e-03 -1.696298e-02 -6.561388e-03 -1.009235e-02
## UREA_T0            2.230292e-02 -6.647338e-03  5.907549e-02 -3.659304e-02
## HIERRO_T0         -1.598124e-02 -7.663829e-03  9.753732e-02 -4.882519e-02
## TRANSF_T0         -2.004095e-02 -4.090444e-02  6.306716e-02 -8.195304e-02
## FERR_T0            1.554729e-02 -8.481643e-02 -5.392052e-02  5.102036e-02
## Ile_T0            -5.137047e-02 -1.814508e-02 -9.762338e-02  6.681650e-02
## Leu_T0            -4.979559e-02 -3.952419e-02 -6.160850e-02  9.519243e-02
## Val_T0            -8.624054e-02 -6.936978e-02 -5.354972e-02  7.621330e-02
## Ala_T0            -5.731886e-02  1.032876e-02 -3.375025e-02 -3.066922e-02
## Pro_T0            -5.170318e-02  3.301973e-04 -3.183349e-02  4.499325e-02
## Gly_T0             2.584130e-02  9.960660e-03  8.524526e-02 -1.637441e-02
## Ser_T0             9.667183e-03  7.528748e-04  2.183134e-02  3.237344e-02
## Trp_T0            -7.514744e-02 -4.320357e-02 -1.008027e-02  7.696338e-02
## Phe_T0            -3.174623e-03 -1.305164e-02 -3.630534e-02  5.554906e-02
## Met_T0            -4.561577e-02 -8.413285e-02 -1.434409e-02  6.786305e-02
## Orn_T0             2.626557e-02 -3.866191e-02  5.930407e-02  1.107789e-01
## Arg_T0             3.758529e-03  2.559945e-02 -9.669983e-03  3.575544e-02
## His_T0            -5.772913e-02 -4.527846e-02  5.579843e-02  9.148808e-03
## Asn_T0            -7.118079e-02 -7.034770e-02  5.249856e-02  7.005387e-02
## Asp_T0             5.081524e-02  6.263675e-02 -1.416829e-02  2.775880e-03
## Glu_T0             2.911597e-02  5.553226e-02 -2.818070e-02  1.876658e-02
## Gln_T0            -8.858740e-02 -9.707748e-02  2.529117e-02  4.358871e-02
## Cit_T0            -3.348022e-02 -2.887103e-02  6.845149e-02  3.061526e-02
## Tyr_T0            -3.299038e-02 -5.502142e-02 -2.302697e-02  5.891471e-02
## Thr_T0            -3.758933e-02 -3.088679e-02  7.741645e-06  3.502390e-02
## Lys_T0            -8.360483e-02 -2.639707e-02 -2.841377e-02  9.333770e-02
## Creatinine_T0     -7.268980e-02 -1.946597e-02 -5.505576e-02 -1.971956e-03
## Kynurenine_T0     -2.184854e-02 -2.927665e-02 -2.226942e-03  1.634914e-02
## Putrescine_T0     -1.422032e-03  2.653869e-02 -2.151411e-02 -8.102914e-02
## Sarcosine_T0      -4.702161e-02 -3.998080e-02 -8.360544e-02  4.504707e-03
## Serotonin_T0      -3.660384e-02 -4.174247e-02 -3.714212e-02  2.028322e-02
## Taurine_T0         2.303257e-02  8.874477e-03  5.537447e-02  5.992887e-02
## SDMA_T0           -1.083996e-02 -1.442000e-02 -5.837398e-03  5.334632e-03
## C0_T0             -5.546852e-02 -9.703710e-03  7.288252e-03  6.949636e-02
## C2_T0             -5.357889e-02 -1.853974e-02 -7.294737e-04  3.031611e-02
## C3.OH_T0          -8.049950e-04 -1.685275e-02 -5.720577e-03 -4.501664e-03
## C6..C4.1.DC._T0    6.345401e-02  1.514277e-02  2.980171e-02  1.486396e-02
## C5.DC..C6.OH._T0   7.444036e-03  3.325842e-02 -1.126359e-02 -5.711161e-02
## C7.DC_T0           2.030726e-02  9.218933e-03 -3.946623e-02 -6.761951e-02
## C8_T0              5.195643e-04 -1.544026e-02 -6.039082e-03 -5.888426e-03
## C10_T0            -5.194313e-03 -1.390781e-02 -8.961734e-03 -8.080121e-03
## C10.1_T0          -1.149999e-03 -1.654954e-02 -5.999145e-03 -2.400591e-03
## C10.2_T0          -1.097363e-03 -1.741047e-02 -6.384232e-03 -4.243890e-03
## C14.1_T0          -1.253263e-03 -1.556003e-02 -7.347215e-03 -4.047762e-03
## C14.2_T0          -3.964059e-04 -1.654552e-02 -6.779788e-03 -4.183592e-03
## C16.1_T0          -4.211973e-04 -1.642898e-02 -6.473875e-03 -3.383211e-03
## C16.2_T0           1.722988e-04 -1.658912e-02 -5.823732e-03 -3.149858e-03
## C16.2.OH_T0        3.835253e-04 -1.642682e-02 -5.763418e-03 -3.266227e-03
## C18.1_T0          -5.738362e-04 -1.499314e-02 -5.094615e-03 -3.146759e-03
## C18.1.OH_T0        3.341911e-04 -1.667711e-02 -5.460129e-03 -3.208975e-03
## C18.2_T0          -8.515310e-05 -1.642368e-02 -5.634036e-03 -2.927529e-03
## lysoPC.a.C16.0_T0 -1.995276e-02  5.948158e-02  3.836247e-02 -1.932225e-02
## lysoPC.a.C16.1_T0 -9.343917e-03  2.293789e-02  2.386768e-02 -3.062042e-02
## lysoPC.a.C17.0_T0  3.778171e-04  2.923538e-03  2.190826e-02 -1.362318e-02
## lysoPC.a.C18.0_T0 -4.834820e-03  3.863049e-02  7.027255e-02 -4.261001e-03
## lysoPC.a.C18.1_T0 -4.225782e-02  2.608724e-02  6.014253e-02 -2.527009e-02
## lysoPC.a.C18.2_T0 -5.465281e-02 -3.844544e-02  6.696464e-02  2.407618e-02
## lysoPC.a.C20.3_T0 -3.637022e-02 -1.191781e-03  3.786481e-02 -1.880932e-02
## lysoPC.a.C20.4_T0 -6.922633e-02 -9.356772e-03  3.990059e-02  1.728300e-02
## lysoPC.a.C24.0_T0 -1.561510e-03 -1.288768e-02 -2.857343e-03 -7.335436e-03
## lysoPC.a.C26.0_T0 -1.616745e-02  1.731921e-02  2.893751e-03 -2.142149e-02
## lysoPC.a.C26.1_T0 -1.729590e-03 -1.368794e-02 -6.056346e-03 -5.898450e-03
## lysoPC.a.C28.0_T0  4.752687e-03  3.482702e-03  3.577506e-02 -9.533845e-03
## lysoPC.a.C28.1_T0 -1.893440e-03 -7.688304e-03 -3.171737e-03 -9.315131e-03
## PC.aa.C24.0_T0    -7.983825e-03 -5.865434e-04  9.092212e-03  4.676275e-03
## PC.aa.C28.1_T0    -3.280171e-02 -1.913532e-02  7.975742e-03 -5.340965e-03
## PC.aa.C30.0_T0    -2.399085e-02 -6.928877e-03  4.078529e-03 -6.915216e-03
## PC.aa.C32.0_T0    -8.762208e-02  6.070100e-03 -2.024989e-02 -6.062551e-03
## PC.aa.C32.1_T0    -7.973980e-02  4.021222e-02  2.102517e-02 -5.529703e-02
## PC.aa.C32.3_T0    -1.634294e-03 -1.442280e-02 -4.024442e-03 -3.545690e-03
## PC.aa.C34.1_T0    -1.358691e-01  6.207255e-02  1.554621e-02 -4.307656e-02
## PC.aa.C34.2_T0    -1.123287e-01  1.886532e-02  1.450294e-02 -4.542198e-03
## PC.aa.C34.3_T0    -7.558684e-02  2.855907e-02  4.723807e-02 -3.041284e-02
## PC.aa.C34.4_T0    -1.114983e-02 -1.466927e-02  4.880546e-03 -9.268556e-04
## PC.aa.C36.0_T0    -4.866453e-03  1.096711e-02  9.491798e-03 -4.336857e-03
## PC.aa.C36.1_T0    -8.995863e-02  4.629354e-03  6.238861e-02  1.911958e-02
## PC.aa.C36.2_T0    -1.065939e-01 -1.792491e-02  8.123840e-02  4.749818e-02
## PC.aa.C36.3_T0    -1.181771e-01  3.399225e-02  4.548404e-02 -1.760972e-02
## PC.aa.C36.4_T0    -1.507633e-01  2.487290e-02  2.653414e-02  3.092012e-02
## PC.aa.C36.5_T0    -9.318970e-02  1.338077e-02  1.927210e-02 -9.116457e-03
## PC.aa.C38.0_T0    -2.628371e-02  1.543167e-02  2.688698e-02  3.004131e-03
## PC.aa.C38.1_T0     4.536433e-02  2.736050e-02  1.142073e-02  4.422727e-02
## PC.aa.C38.3_T0    -1.040235e-01  2.104650e-02  5.442356e-02  1.178817e-02
## PC.aa.C38.4_T0    -1.375978e-01  6.906655e-03  7.441293e-02  5.955489e-02
## PC.aa.C38.5_T0    -1.360513e-01  1.946649e-02  7.619882e-02  1.220394e-02
## PC.aa.C38.6_T0    -1.293613e-01  5.835488e-02 -2.094383e-03  1.803024e-02
## PC.aa.C40.1_T0    -1.007534e-02  1.674150e-02  1.933822e-02  1.014350e-02
## PC.aa.C40.2_T0     2.054555e-02  2.057545e-02  5.585775e-03 -1.713532e-02
## PC.aa.C40.3_T0     1.201239e-02  1.621059e-02  5.295341e-03 -1.596623e-02
## PC.aa.C40.4_T0    -7.560109e-03  1.638590e-02  1.959575e-02  5.641087e-04
## PC.aa.C40.5_T0    -6.222018e-02  5.328775e-03  3.972368e-02  1.891533e-02
## PC.aa.C40.6_T0    -1.213666e-01  4.723530e-02  1.831895e-02  5.592893e-02
## PC.aa.C42.0_T0    -3.384753e-04 -5.771281e-03 -2.023808e-03 -3.683554e-03
## PC.aa.C42.1_T0     1.536492e-03 -5.732066e-03 -1.758631e-03 -4.819984e-03
## PC.aa.C42.2_T0     6.728100e-03  1.601493e-03  8.878431e-04 -9.612972e-03
## PC.aa.C42.4_T0     1.079405e-02  4.747745e-04  2.569766e-03 -1.080221e-02
## PC.aa.C42.5_T0     2.582920e-03 -6.418000e-03 -5.546819e-04 -6.565432e-03
## PC.aa.C42.6_T0    -9.373045e-03  1.035186e-03  3.348758e-02  8.827461e-03
## PC.ae.C30.0_T0    -1.338956e-03 -1.545288e-02 -2.544031e-03 -6.353871e-03
## PC.ae.C32.1_T0    -2.601108e-02 -2.400430e-02  6.346597e-03 -4.861273e-03
## PC.ae.C32.2_T0    -4.140936e-03 -1.560429e-02  3.069318e-03 -3.652162e-03
## PC.ae.C34.0_T0    -4.019683e-03 -1.529466e-02 -1.046053e-03 -7.209058e-04
## PC.ae.C34.1_T0    -5.235666e-02 -1.821602e-03  2.540444e-02 -8.241284e-03
## PC.ae.C34.2_T0    -5.706711e-02 -3.910851e-02  6.903988e-02  1.429663e-02
## PC.ae.C34.3_T0    -4.383190e-02 -3.545553e-02  4.977467e-02  1.912311e-02
## PC.ae.C36.0_T0    -5.235953e-03 -3.264953e-03  3.508926e-03 -8.524646e-03
## PC.ae.C36.1_T0     1.866281e-02  5.270931e-02  1.827000e-02 -2.680179e-02
## PC.ae.C36.2_T0    -2.318909e-02  1.469721e-02  5.072248e-02 -1.326027e-02
## PC.ae.C36.3_T0    -4.434208e-02 -2.650860e-02  4.082930e-02  1.552741e-02
## PC.ae.C36.4_T0    -8.882630e-02 -6.402228e-02  4.444892e-02  5.145780e-02
## PC.ae.C36.5_T0    -8.686783e-02 -5.279710e-02  3.934474e-02  3.862369e-02
## PC.ae.C38.0_T0    -2.114916e-02 -7.383581e-04  1.324741e-02 -1.162616e-02
## PC.ae.C38.2_T0     4.363949e-02  5.447120e-02  3.109223e-02 -4.030964e-02
## PC.ae.C38.3_T0     2.251487e-02  4.497601e-02  8.119311e-03 -4.358758e-03
## PC.ae.C38.4_T0    -5.871994e-02 -1.710438e-02  3.978414e-02  3.367602e-02
## PC.ae.C38.5_T0    -1.054947e-01 -3.663010e-02  4.535264e-02  6.952506e-02
## PC.ae.C38.6_T0    -6.775473e-02 -2.766233e-02  2.528899e-02  3.025771e-02
## PC.ae.C40.1_T0     1.541510e-03  1.496883e-02  9.974178e-03 -1.410046e-02
## PC.ae.C40.2_T0     2.551408e-02  2.865062e-02  1.227763e-02 -2.580354e-02
## PC.ae.C40.3_T0     3.878820e-02  4.275935e-02  1.210894e-02 -1.321489e-02
## PC.ae.C40.4_T0     1.397030e-02  2.240093e-02  1.841033e-02 -5.708208e-03
## PC.ae.C40.5_T0     1.469480e-02  2.967998e-02  1.396232e-02 -6.595387e-03
## PC.ae.C40.6_T0    -2.906283e-02 -1.362632e-02  8.384364e-03  8.826663e-03
## PC.ae.C42.1_T0     9.406807e-03  1.054053e-02  4.049812e-03 -1.241204e-02
## PC.ae.C42.2_T0     5.632220e-03  3.395982e-03  2.729262e-03 -1.066297e-02
## PC.ae.C42.3_T0     9.635461e-03  6.570715e-03  6.286944e-03 -1.427222e-02
## PC.ae.C42.4_T0     1.946517e-03 -6.975062e-03  3.670406e-03 -4.764727e-03
## PC.ae.C42.5_T0     7.755425e-04  2.655460e-03  8.816230e-03 -5.572373e-03
## PC.ae.C44.3_T0     7.631846e-03 -5.533673e-03 -6.850433e-04 -8.754091e-03
## PC.ae.C44.4_T0     1.008239e-03 -1.222418e-02 -5.388078e-04 -7.079159e-03
## PC.ae.C44.5_T0    -2.071341e-02 -3.508820e-02  4.879852e-04  4.048929e-03
## PC.ae.C44.6_T0    -9.501347e-03 -3.081684e-02  6.255986e-03  1.050685e-02
## SM..OH..C14.1_T0  -3.141344e-02 -2.799530e-02  1.121089e-02  1.003209e-03
## SM..OH..C16.1_T0  -1.588592e-02 -1.852399e-02 -7.180153e-03 -2.388051e-03
## SM..OH..C22.1_T0  -9.104943e-02 -3.802572e-02  6.990730e-03  1.814329e-02
## SM..OH..C22.2_T0  -5.178924e-02 -2.480375e-03  2.360438e-02 -6.091544e-03
## SM..OH..C24.1_T0  -8.649874e-03 -1.966559e-02 -6.434049e-03  1.124302e-03
## SM.C16.0_T0       -1.488562e-01 -2.262330e-02 -2.134145e-02  4.166406e-02
## SM.C16.1_T0       -1.130297e-01 -1.969845e-02  1.669600e-02  1.420524e-02
## SM.C18.0_T0       -9.126795e-02  2.476338e-02 -9.998411e-02  7.515556e-03
## SM.C18.1_T0       -7.861392e-02  5.088848e-03 -4.145136e-02 -6.687798e-03
## SM.C20.2_T0       -2.986033e-03 -1.536661e-02 -6.170579e-03 -2.569133e-03
## SM.C24.0_T0       -1.067910e-01 -2.352615e-02 -6.989770e-03  1.212503e-02
## SM.C24.1_T0       -1.317757e-01  3.616167e-02 -4.653525e-02  1.629150e-02
## MEDDM_T2           5.335230e-04 -1.671410e-02 -5.427374e-03 -2.991869e-03
## MEDCOL_T2          5.335230e-04 -1.671410e-02 -5.427374e-03 -2.991869e-03
## MEDINF_T2         -1.621857e-03 -1.473630e-02 -3.032059e-03 -2.519910e-03
## MEDHTA_T2         -2.083133e-04 -2.368360e-02 -1.279995e-02 -1.143359e-02
## GLU_T2            -1.118887e-02 -5.800370e-02  8.254125e-03 -1.092430e-01
## INS_T2             3.090819e-02 -1.930247e-02 -1.230006e-01 -6.664509e-02
## HOMA_T2            1.440253e-02 -2.047260e-02 -8.632747e-02 -5.830863e-02
## HBA1C_T2          -2.599691e-04 -6.317939e-02  3.261653e-02 -3.200315e-02
## HBA1C.mmol.mol_T2  2.548893e-03 -9.128519e-02  9.628494e-02 -6.058926e-02
## PESO_T2           -8.422618e-03 -1.074308e-01 -8.275442e-02 -3.714993e-02
## bmi_T2            -7.553918e-03 -9.080199e-02 -4.640095e-02 -7.189316e-02
## CC_T2              5.353340e-04 -2.547399e-02 -5.263104e-03 -4.043000e-03
## CINT_T2           -3.628044e-03 -9.286452e-02 -4.509006e-02 -2.668227e-02
## CAD_T2            -1.030943e-02 -7.455611e-02 -5.792459e-03 -6.552317e-02
## TAD_T2             1.854242e-02 -4.129855e-02  4.584529e-02 -2.928613e-02
## TAS_T2            -8.975238e-03 -8.755485e-02  4.203579e-02 -1.106377e-02
## TG_T2             -8.086568e-03  2.133527e-02 -6.690457e-02 -1.054053e-01
## COL_T2            -3.390887e-02  4.053377e-02  5.647826e-02 -9.609843e-02
## LDL_T2            -3.529295e-02  4.725990e-02  1.961007e-02 -5.152556e-02
## HDL_T2            -1.236031e-02 -4.874211e-03  1.700483e-01 -3.913569e-02
## VLDL_T2            1.734216e-02 -1.787368e-03 -7.586753e-02 -1.041669e-01
## PCR_T2            -5.048295e-02 -5.045871e-02 -2.795160e-02 -7.567664e-02
## LEP_T2            -2.613449e-02 -2.895721e-03 -2.138457e-02 -1.238293e-01
## ADIPO_T2           5.953662e-02 -6.960679e-02  1.319751e-01 -1.363074e-01
## GOT_T2             7.922514e-02 -6.309165e-02 -3.240167e-02  1.361872e-02
## GPT_T2             2.797536e-02 -1.220010e-01 -9.896424e-02  6.792265e-03
## GGT_T2             4.093309e-03 -1.092805e-02 -3.107587e-02 -2.375686e-02
## URICO_T2           6.449549e-03 -9.003131e-02 -7.113357e-02 -6.111930e-02
## CREAT_T2          -1.101451e-03 -2.428540e-02 -8.121712e-03 -1.727923e-02
## UREA_T2            9.246213e-03 -6.329688e-02  1.065763e-02 -9.997231e-03
## HIERRO_T2          2.519406e-02 -6.479921e-02  4.174764e-02 -2.156146e-02
## TRANSF_T2         -5.450842e-03  2.204272e-02  3.987572e-02 -5.594969e-02
## FERR_T2            2.388398e-02 -1.071755e-01 -2.777856e-02  1.422247e-02
## Ile_T2             1.721587e-02  2.206445e-02 -8.740408e-02  1.344094e-02
## Leu_T2             4.333834e-02  1.040659e-02 -8.080355e-02  1.721225e-03
## Val_T2             3.157222e-02  3.083556e-02 -8.045533e-02  1.987207e-02
## Ala_T2             2.511295e-02  2.607178e-02 -3.506455e-02  3.353766e-02
## Pro_T2             2.682571e-02  3.102300e-02 -1.958630e-02  7.097354e-02
## Gly_T2             6.015683e-02  8.152288e-03  7.403439e-02 -1.341439e-02
## Ser_T2             5.469659e-02 -3.715034e-03  6.888119e-02  1.962146e-02
## Trp_T2             1.051456e-02  2.220434e-05 -4.249277e-02  6.963794e-02
## Phe_T2             5.919895e-02 -1.875741e-03 -5.919607e-02  1.386829e-02
## Met_T2            -4.358204e-02 -1.350427e-02  3.030178e-02 -2.177592e-02
## Orn_T2             8.910752e-02  3.440769e-03  3.481043e-02  9.715690e-02
## Arg_T2             6.449982e-02  1.334019e-02  1.130873e-02  2.978265e-02
## His_T2             5.598669e-02 -1.558040e-02  6.451985e-03 -5.906079e-03
## Asn_T2             2.967764e-02 -2.541473e-02  1.983555e-02  6.247737e-02
## Asp_T2             9.303459e-02  3.777466e-02  8.463650e-03  1.013563e-01
## Glu_T2             8.972179e-02  5.666394e-02 -2.963553e-02  6.097157e-02
## Gln_T2             1.979045e-03 -3.800938e-02  2.249517e-02  4.005224e-02
## Cit_T2             5.104910e-02  1.006388e-02  2.982796e-02  7.170646e-02
## Tyr_T2             3.225136e-02  1.711157e-02 -4.908838e-02  7.053955e-02
## Thr_T2             1.405572e-02 -3.251896e-02  3.622022e-02  1.057131e-01
## Lys_T2             3.625433e-02  2.472168e-02 -4.211960e-02  8.376134e-02
## Creatinine_T2      1.057030e-02 -4.221868e-02 -8.522527e-02 -2.521644e-02
## Kynurenine_T2      4.286078e-03 -1.084459e-02 -2.183669e-02  1.270585e-02
## Putrescine_T2     -3.517004e-02  4.758360e-02 -1.088779e-01 -7.627085e-03
## Sarcosine_T2      -1.389908e-02 -3.597845e-02 -8.449580e-02  1.159279e-02
## Serotonin_T2       2.677595e-03 -7.077001e-03 -5.041005e-02 -4.238170e-02
## Taurine_T2        -1.135532e-02  4.302486e-02  7.650946e-02  8.742790e-03
## SDMA_T2            2.331070e-03 -1.687652e-02 -1.117736e-02 -1.308855e-02
## C0_T2              5.136815e-02  1.912499e-02 -4.566347e-03  6.330069e-02
## C2_T2             -2.619780e-02 -1.845573e-02  6.319407e-03 -3.738991e-03
## C3.OH_T2          -3.210998e-04 -1.654680e-02 -5.493435e-03 -4.559499e-03
## C6..C4.1.DC._T2   -4.799601e-02 -1.765527e-02 -4.809238e-02  6.924043e-02
## C5.DC..C6.OH._T2   7.977267e-03 -2.763121e-02 -1.523796e-02 -2.478041e-02
## C7.DC_T2          -6.199207e-03 -6.434166e-04  3.408793e-02 -4.390904e-02
## C8_T2             -2.038211e-04 -1.568240e-02 -3.131575e-03 -5.629342e-03
## C10_T2             2.576608e-04 -1.564540e-02 -2.324640e-03 -4.254671e-03
## C10.1_T2           8.993374e-04 -1.705864e-02 -3.760236e-03 -2.635805e-03
## C10.2_T2          -1.168486e-03 -1.583713e-02 -4.687215e-03 -4.230737e-03
## C14.1_T2           8.301354e-04 -1.734898e-02 -5.369053e-03 -4.701638e-03
## C14.2_T2           3.900950e-04 -1.744887e-02 -4.983423e-03 -5.154641e-03
## C16.1_T2           3.981869e-04 -1.663127e-02 -5.459102e-03 -4.131066e-03
## C16.2_T2           1.703462e-04 -1.667970e-02 -5.303536e-03 -3.501014e-03
## C16.2.OH_T2        4.198663e-04 -1.670490e-02 -5.096444e-03 -3.297112e-03
## C18.1_T2           9.965502e-04 -1.652432e-02 -5.393868e-03 -3.573192e-03
## C18.1.OH_T2        3.563761e-04 -1.662586e-02 -5.484417e-03 -3.195867e-03
## C18.2_T2           5.830794e-04 -1.698207e-02 -6.357399e-03 -2.959610e-03
## lysoPC.a.C14.0_T2  4.129155e-02  1.482926e-02 -2.949976e-02  2.092916e-02
## lysoPC.a.C16.0_T2  4.867326e-02  6.091244e-02  2.343420e-02  3.995517e-02
## lysoPC.a.C16.1_T2  2.112456e-02  7.879195e-03 -3.084212e-03  3.967863e-03
## lysoPC.a.C17.0_T2  1.870546e-02  1.829343e-03  9.362323e-03  2.559791e-03
## lysoPC.a.C18.0_T2  4.008249e-02  5.508928e-02  4.925094e-02  5.926997e-02
## lysoPC.a.C18.1_T2  3.494736e-02  3.657744e-02  3.136254e-02  2.450641e-02
## lysoPC.a.C18.2_T2  2.967963e-02  2.411989e-02  4.622274e-02  5.362413e-02
## lysoPC.a.C20.3_T2  1.679209e-02 -5.474501e-03 -6.932282e-03  4.182618e-03
## lysoPC.a.C20.4_T2  2.233838e-02  4.602703e-03  1.012627e-02 -1.208096e-02
## lysoPC.a.C24.0_T2  2.521468e-03 -1.454099e-02 -2.993237e-03 -2.099184e-03
## lysoPC.a.C26.0_T2  2.314272e-02  3.940453e-02  2.757015e-03  6.353454e-02
## lysoPC.a.C26.1_T2  3.669205e-03 -1.461972e-02 -6.244206e-03 -5.180545e-03
## lysoPC.a.C28.0_T2  7.017750e-02  6.829672e-02  3.719571e-02 -3.808971e-03
## lysoPC.a.C28.1_T2  7.107187e-03 -1.265816e-02 -4.638762e-03 -7.794940e-04
## PC.aa.C24.0_T2     4.792009e-02  1.611711e-04 -1.496589e-03 -4.104744e-02
## PC.aa.C28.1_T2    -2.258037e-03  1.742778e-03  7.092117e-03 -1.395301e-02
## PC.aa.C30.0_T2    -2.257284e-03 -7.089688e-03 -1.561367e-02 -4.578557e-03
## PC.aa.C32.0_T2    -1.661137e-02  4.223363e-02 -3.946283e-02 -2.872698e-02
## PC.aa.C32.1_T2    -1.024004e-02  2.490432e-02 -3.466535e-02 -4.431384e-03
## PC.aa.C32.3_T2     1.468439e-03 -1.434961e-02 -5.246711e-03 -4.469718e-03
## PC.aa.C34.1_T2    -2.412064e-02  7.179342e-02  4.922817e-04 -1.312027e-02
## PC.aa.C34.2_T2    -2.398395e-02  6.458885e-02  2.008649e-02  2.544103e-02
## PC.aa.C34.3_T2     4.525159e-03  2.199950e-02 -4.887854e-03  2.757410e-02
## PC.aa.C34.4_T2     4.276433e-04 -1.386276e-02 -5.283069e-03 -1.829460e-03
## PC.aa.C36.0_T2     1.408847e-02 -7.568838e-04 -1.798447e-03  8.260845e-03
## PC.aa.C36.1_T2    -1.320246e-02  4.004558e-02  2.420103e-02  3.831552e-02
## PC.aa.C36.2_T2    -1.097672e-02  5.296806e-02  4.244622e-02  5.035341e-02
## PC.aa.C36.3_T2    -7.883061e-03  3.470613e-02 -3.594529e-03  2.246660e-02
## PC.aa.C36.4_T2    -6.117462e-02  4.168411e-02 -3.227996e-02 -5.108840e-02
## PC.aa.C36.5_T2    -1.562816e-02  2.784808e-02 -3.803730e-02 -1.854257e-02
## PC.aa.C38.0_T2     3.405639e-04  1.700928e-02 -7.435578e-03  7.176823e-03
## PC.aa.C38.1_T2     3.208236e-02 -2.523213e-02 -3.909691e-03  1.273222e-02
## PC.aa.C38.3_T2    -1.969331e-03  5.004234e-02 -2.832662e-03  1.391324e-02
## PC.aa.C38.4_T2    -3.046920e-02  4.311556e-02  1.295728e-02  2.341789e-03
## PC.aa.C38.5_T2    -2.194054e-02  4.601320e-02  7.204815e-03 -2.232764e-02
## PC.aa.C38.6_T2    -5.865667e-02  9.728755e-02  5.502724e-03 -4.098206e-02
## PC.aa.C40.1_T2     5.417858e-02  3.581962e-02  3.471026e-02  8.593136e-02
## PC.aa.C40.2_T2     3.038402e-02 -3.411823e-03 -1.051319e-02  9.636587e-03
## PC.aa.C40.3_T2     2.418455e-02 -5.609226e-03 -9.403537e-03  4.191854e-03
## PC.aa.C40.4_T2     2.630906e-02  5.646747e-03  8.326972e-03  7.019310e-03
## PC.aa.C40.5_T2     1.564386e-03  1.596877e-02  9.921107e-03 -1.055617e-03
## PC.aa.C40.6_T2    -3.603300e-02  8.247443e-02  1.434684e-02 -4.994244e-03
## PC.aa.C42.0_T2     7.115705e-03 -1.191451e-02 -6.953877e-03  2.351273e-03
## PC.aa.C42.1_T2     6.158132e-03 -1.346536e-02 -6.127439e-03  5.922023e-04
## PC.aa.C42.2_T2     1.484610e-02 -1.043891e-02 -4.496974e-03 -2.062524e-03
## PC.aa.C42.4_T2     1.320982e-02 -1.065920e-02 -4.646656e-03 -1.215163e-03
## PC.aa.C42.5_T2     6.680523e-03 -1.147817e-02 -4.461174e-03 -2.857915e-03
## PC.aa.C42.6_T2     1.996814e-02  4.411738e-02  1.493972e-02 -5.713965e-04
## PC.ae.C30.0_T2     3.344044e-02  5.892940e-03 -7.509632e-03  7.031713e-03
## PC.ae.C32.1_T2    -1.816300e-03 -1.007400e-02 -1.102167e-03 -4.259471e-03
## PC.ae.C32.2_T2     2.381175e-03 -1.171621e-02 -1.992898e-03 -4.359325e-03
## PC.ae.C34.0_T2     5.582478e-04 -1.256390e-02 -3.668750e-03 -5.859613e-03
## PC.ae.C34.1_T2    -2.985953e-04  1.197044e-02  2.199209e-03 -1.768993e-03
## PC.ae.C34.2_T2     5.129224e-04  1.072902e-02  2.740043e-02  1.067954e-02
## PC.ae.C34.3_T2    -1.300180e-03  8.174920e-03  3.433070e-02  1.316832e-02
## PC.ae.C36.0_T2     4.867268e-03 -5.772549e-03 -2.255814e-03 -4.840174e-03
## PC.ae.C36.1_T2     7.044954e-02  3.139541e-02 -7.032701e-03  2.285183e-02
## PC.ae.C36.2_T2     1.700228e-02  1.895934e-02  2.429909e-02  1.517971e-02
## PC.ae.C36.3_T2    -1.330701e-03 -3.871002e-03  8.505231e-03  1.221621e-02
## PC.ae.C36.4_T2    -1.206516e-02  3.448680e-05  9.839231e-03  6.630659e-03
## PC.ae.C36.5_T2    -1.529576e-02  1.811101e-03  1.269579e-02  2.510083e-03
## PC.ae.C38.0_T2     2.152600e-03  1.407403e-03 -2.567785e-03 -5.155444e-03
## PC.ae.C38.2_T2     6.184151e-02  1.645891e-02 -2.053148e-03  2.334096e-02
## PC.ae.C38.3_T2     6.958746e-02  2.055900e-02 -8.981885e-03  1.317036e-02
## PC.ae.C38.4_T2    -4.858352e-03  4.199892e-03  7.550304e-03 -1.992471e-03
## PC.ae.C38.5_T2    -2.245176e-02  1.581575e-02 -2.724343e-04  8.627956e-03
## PC.ae.C38.6_T2    -1.416607e-02  8.489767e-03  1.292476e-04  2.397077e-03
## PC.ae.C40.1_T2     2.618671e-02 -2.334381e-06 -3.587997e-03  4.106083e-03
## PC.ae.C40.2_T2     2.075903e-02  1.629994e-03 -7.748417e-03 -1.420783e-04
## PC.ae.C40.3_T2     6.288411e-02  1.382446e-02 -5.954528e-03  1.386434e-02
## PC.ae.C40.4_T2     3.725597e-02  3.616552e-03  1.250103e-03  4.348071e-03
## PC.ae.C40.5_T2     5.241610e-02  2.138607e-02  5.258925e-03 -5.391652e-03
## PC.ae.C40.6_T2    -3.626280e-03  4.752329e-03  3.786571e-03 -6.588993e-03
## PC.ae.C42.1_T2     1.789557e-02 -9.265420e-03 -7.450293e-03  5.251726e-03
## PC.ae.C42.2_T2     1.548579e-02 -1.068046e-02 -7.401324e-03  2.925121e-03
## PC.ae.C42.3_T2     2.289089e-02 -4.500102e-03 -1.418794e-03  3.917259e-04
## PC.ae.C42.4_T2     9.786602e-03 -1.231603e-02 -9.382795e-04 -1.052683e-03
## PC.ae.C42.5_T2     2.097016e-02 -1.684919e-03 -2.401746e-03  6.243628e-03
## PC.ae.C44.3_T2     4.489241e-02  5.319532e-03  1.677958e-03  6.267753e-02
## PC.ae.C44.4_T2     4.575337e-03 -1.649072e-02 -4.433444e-03 -2.019262e-03
## PC.ae.C44.5_T2     2.689887e-04 -1.850295e-02 -7.228189e-03  6.827175e-03
## PC.ae.C44.6_T2     2.281602e-03 -2.003565e-02 -5.540281e-03  9.672714e-03
## SM..OH..C14.1_T2  -3.128806e-03  7.491248e-03  2.846838e-02 -2.012743e-02
## SM..OH..C16.1_T2  -2.337047e-03 -1.996498e-03  3.425147e-03 -1.401822e-02
## SM..OH..C22.1_T2  -1.460378e-02  1.283401e-02  2.095862e-02 -1.166198e-02
## SM..OH..C22.2_T2   1.103739e-02  2.124836e-02  2.330506e-02 -1.459678e-02
## SM..OH..C24.1_T2  -1.506632e-03 -1.132405e-02 -4.409095e-03 -4.372059e-03
## SM.C16.0_T2       -2.953034e-02  6.955873e-02  2.968863e-02 -1.429604e-02
## SM.C16.1_T2       -2.176239e-02  4.520771e-02  2.844724e-02 -1.435402e-02
## SM.C18.0_T2       -3.193996e-02  5.061410e-02 -2.953849e-02 -5.102235e-02
## SM.C18.1_T2       -2.472939e-02  3.823218e-02  6.380900e-03 -3.559307e-02
## SM.C20.2_T2        3.941159e-04 -1.496786e-02 -7.424851e-03 -3.102055e-03
## SM.C24.0_T2       -2.343616e-02  3.750628e-02  1.502857e-02 -2.759474e-03
## SM.C24.1_T2       -2.394161e-02  6.834633e-02 -9.549456e-03 -1.125271e-02
## MEDDM_T4           6.221103e-04 -1.705296e-02 -4.746287e-03 -1.258012e-02
## MEDCOL_T4         -1.279878e-03 -1.462806e-02 -4.335024e-03 -5.317345e-03
## MEDINF_T4         -1.077442e-03 -1.600652e-02 -9.408243e-03 -4.101081e-03
## MEDHTA_T4         -7.630148e-04 -2.206942e-02 -8.189762e-03  5.209798e-04
## GLU_T4            -2.335043e-02 -7.303913e-02  3.325266e-02 -4.895984e-02
## INS_T4             6.262207e-03 -7.832525e-02 -8.589785e-02 -1.552017e-02
## HOMA_T4           -2.913690e-03 -4.379960e-02 -3.602175e-02 -9.687979e-03
## HBA1C_T4          -3.063996e-03 -6.986846e-02  2.777070e-02 -3.937712e-02
## HBA1C.mmol.mol_T4 -7.227177e-03 -9.957181e-02  6.688474e-02 -7.666988e-02
## PESO_T4           -5.581687e-03 -1.113947e-01 -8.267917e-02 -1.958222e-02
## bmi_T4            -6.284647e-03 -9.656870e-02 -4.804764e-02 -5.061252e-02
## CC_T4             -4.927665e-04 -2.135734e-02 -4.243705e-04 -1.795031e-03
## CINT_T4           -2.542294e-03 -9.694827e-02 -3.110850e-02 -1.952803e-02
## CAD_T4            -3.078503e-03 -8.988065e-02 -1.714567e-02 -7.752544e-02
## TAD_T4            -1.051695e-02 -3.504618e-02  8.120200e-03 -5.891459e-02
## TAS_T4            -3.017671e-02 -5.098324e-02  5.464420e-03 -5.655045e-02
## TG_T4             -4.312488e-02  5.874859e-02 -7.270923e-02 -7.012975e-02
## COL_T4            -3.381578e-02  4.722974e-02  6.574965e-02 -6.535415e-02
## LDL_T4            -2.136601e-02  5.759097e-02  2.882439e-02 -5.418709e-02
## HDL_T4            -2.386914e-02 -9.187241e-03  1.784191e-01 -7.362755e-03
## VLDL_T4           -5.363939e-03  6.989135e-02 -6.740415e-02 -8.616311e-02
## PCR_T4            -8.291790e-02 -4.313247e-02 -4.297700e-03 -1.222779e-02
## LEP_T4            -5.003410e-02 -9.852481e-03 -2.310543e-02 -3.564679e-02
## ADIPO_T4           8.887434e-02 -2.827812e-02  1.045157e-01 -1.467068e-01
## GOT_T4             7.457260e-02 -8.108751e-02  3.989564e-02 -9.971311e-04
## GPT_T4             3.503376e-02 -9.067913e-02 -2.791009e-02 -6.942741e-03
## GGT_T4            -1.079355e-02  1.347402e-02 -1.209469e-02  5.379085e-02
## URICO_T4           1.216507e-02 -7.685507e-02 -6.200506e-02 -3.406470e-02
## CREAT_T4           3.378724e-04 -2.445086e-02 -8.398565e-03 -9.871337e-03
## UREA_T4            8.528855e-03 -5.255088e-02  1.295444e-01  4.712962e-02
## HIERRO_T4         -1.662116e-02  1.615284e-02  5.311776e-04 -1.093656e-01
## TRANSF_T4         -3.037808e-02 -2.602045e-02  4.948900e-02  4.605902e-03
## FERR_T4            2.197843e-02 -8.527818e-02 -2.604519e-02  1.790478e-02
## Ile_T4             6.543982e-02  5.926885e-03 -7.198042e-02 -2.585782e-02
## Leu_T4             5.069705e-02 -5.163313e-03 -6.172129e-02 -5.965764e-03
## Val_T4             2.705059e-02  1.359068e-02 -2.942072e-02 -1.671233e-02
## Ala_T4             3.727865e-02  3.287996e-02 -5.343688e-02  1.735262e-02
## Pro_T4             3.423316e-02  3.056576e-02  1.449866e-02  3.752052e-02
## Gly_T4             8.064635e-02  4.319920e-02  2.923927e-02 -3.900687e-02
## Ser_T4             1.068991e-02 -5.360095e-04  2.055315e-02 -1.833503e-02
## Trp_T4            -6.711082e-03 -8.434375e-03 -1.371399e-02  5.703897e-02
## Phe_T4             5.878263e-02  1.152045e-02 -7.751260e-03 -3.971354e-03
## Met_T4            -1.571397e-02 -3.681075e-02  1.401116e-03 -2.851400e-02
## Orn_T4             4.259717e-02  1.855289e-02  6.309745e-02  3.943508e-02
## Arg_T4             3.475179e-02  3.817134e-02  1.042684e-04 -3.191402e-02
## His_T4             6.035623e-02  1.428180e-02  2.091095e-02 -3.206589e-02
## Asn_T4             4.563756e-02 -7.671654e-03  7.756611e-03  1.896251e-02
## Asp_T4             4.927814e-02  1.872835e-03 -5.607167e-03  2.995203e-02
## Glu_T4             6.366851e-02  5.005528e-02  5.878442e-03  2.707172e-02
## Gln_T4            -3.129997e-02 -1.168173e-01  3.990498e-02 -2.741574e-02
## Cit_T4             1.129950e-02  1.543412e-02  4.084034e-02 -3.487535e-03
## Tyr_T4             3.542797e-02  7.505496e-03 -2.542831e-03  4.446905e-02
## Thr_T4             3.370749e-02  1.114443e-02  2.791434e-02  3.492639e-02
## Lys_T4             3.838280e-02 -2.497339e-02 -2.867644e-02 -3.597825e-02
## Creatinine_T4      3.309588e-02  1.104996e-02 -5.124964e-02 -3.218996e-02
## Kynurenine_T4      2.106531e-02 -1.394489e-02 -3.474016e-02  7.061174e-02
## Putrescine_T4     -8.483349e-02  1.529647e-02 -5.026553e-02  1.190210e-01
## Sarcosine_T4      -1.177845e-02 -3.288678e-02 -3.811990e-02  7.868818e-02
## Serotonin_T4      -4.284880e-03 -4.406096e-03 -4.100236e-02 -4.564248e-02
## Taurine_T4        -8.950146e-03 -7.928578e-02  4.921781e-02 -2.440191e-02
## SDMA_T4            3.687367e-03 -7.157059e-03 -1.148116e-02 -6.233502e-03
## C0_T4             -5.141620e-03  2.045451e-02  2.580952e-02  2.051326e-02
## C2_T4              1.784705e-02  1.161645e-02 -4.414147e-02 -5.831901e-02
## C3.OH_T4           7.054105e-04 -1.895762e-02 -4.814558e-03 -3.414600e-03
## C6..C4.1.DC._T4   -9.159270e-02 -3.639221e-02 -4.041502e-02  9.696004e-02
## C5.DC..C6.OH._T4   2.287131e-03 -1.252604e-02  1.462209e-02  2.657713e-02
## C7.DC_T4           1.676911e-02 -1.226962e-02  6.814039e-03  4.522521e-03
## C8_T4              2.049179e-03 -2.013561e-02 -4.256355e-03 -4.126333e-03
## C10_T4             4.748747e-03 -1.757094e-02 -3.597221e-03 -5.067743e-03
## C10.1_T4           2.951269e-03 -1.834806e-02 -4.631755e-03 -3.266517e-03
## C10.2_T4           2.915242e-04 -1.767538e-02 -4.867431e-03 -1.801703e-03
## C14.1_T4           1.352338e-03 -1.712699e-02 -5.719900e-03 -5.573397e-03
## C14.2_T4           8.748731e-04 -1.744915e-02 -5.186923e-03 -3.217442e-03
## C16.1_T4          -4.802218e-03  1.706512e-03  4.550589e-02 -8.860807e-03
## C16.2_T4           4.153818e-04 -1.671166e-02 -5.930076e-03 -3.482852e-03
## C16.2.OH_T4       -4.855219e-03  1.592772e-03  4.493913e-02 -8.718487e-03
## C18.1_T4           1.489636e-03 -1.580470e-02 -6.624890e-03 -5.587097e-03
## C18.1.OH_T4        5.327879e-04 -1.689038e-02 -5.554705e-03 -3.282125e-03
## C18.2_T4           7.599482e-04 -1.704478e-02 -5.220560e-03 -3.241188e-03
## lysoPC.a.C16.0_T4  5.121107e-02  7.177351e-02 -6.433101e-03 -1.512495e-02
## lysoPC.a.C16.1_T4  4.814257e-02  3.372299e-02 -7.522975e-03 -1.211151e-02
## lysoPC.a.C17.0_T4  2.472207e-02  3.021292e-03  1.075846e-02 -1.401078e-02
## lysoPC.a.C18.0_T4  5.044986e-02  6.161521e-02  5.457132e-02  6.720166e-03
## lysoPC.a.C18.1_T4  5.704308e-02  6.094733e-02  1.642761e-02 -4.281159e-02
## lysoPC.a.C18.2_T4  5.740298e-02 -5.790233e-03  4.470806e-02  5.948071e-04
## lysoPC.a.C20.3_T4  1.076509e-02  1.195988e-03 -1.496281e-02 -1.061877e-02
## lysoPC.a.C20.4_T4  4.276114e-02  3.096234e-02 -3.870057e-02 -6.418373e-02
## lysoPC.a.C24.0_T4  3.073208e-03 -1.730292e-02 -4.485640e-03 -2.884361e-03
## lysoPC.a.C26.0_T4  2.253355e-02  2.152669e-02 -2.563499e-02  1.470922e-02
## lysoPC.a.C26.1_T4  2.694835e-03 -1.483558e-02 -5.639067e-03 -2.672828e-03
## lysoPC.a.C28.0_T4  2.424564e-02  4.551225e-03 -1.081909e-02  5.637048e-02
## lysoPC.a.C28.1_T4  6.121849e-03 -1.263217e-02 -3.313464e-03 -1.035523e-03
## PC.aa.C24.0_T4     2.262053e-02  3.122511e-02 -1.725024e-02  4.618926e-02
## PC.aa.C28.1_T4     2.529209e-03  6.709833e-04  1.005991e-02 -7.491789e-03
## PC.aa.C30.0_T4     4.828646e-03 -1.120518e-03 -1.796308e-02 -1.577906e-03
## PC.aa.C32.0_T4     2.773994e-02  8.742806e-02 -5.272916e-02 -1.707745e-02
## PC.aa.C32.1_T4     1.250721e-02  8.838460e-02 -3.227590e-02  2.784093e-02
## PC.aa.C32.3_T4     1.584270e-03 -1.381786e-02 -4.848805e-03 -3.628922e-03
## PC.aa.C34.1_T4    -7.739405e-03  1.226862e-01 -2.378326e-02 -1.623161e-02
## PC.aa.C34.2_T4    -1.050548e-02  7.313568e-02  4.059138e-03  1.255993e-02
## PC.aa.C34.3_T4    -4.237827e-03  4.912400e-02  2.700112e-02  2.639334e-02
## PC.aa.C34.4_T4    -2.372289e-03 -1.199562e-02 -5.594563e-03  6.523612e-04
## PC.aa.C36.0_T4     1.056348e-02  8.040621e-03  8.857315e-03  3.155503e-03
## PC.aa.C36.1_T4    -4.853587e-02  8.863772e-02  3.882958e-02  3.827715e-02
## PC.aa.C36.2_T4    -3.864676e-02  6.195056e-02  5.833934e-02  6.176635e-02
## PC.aa.C36.3_T4    -4.622997e-02  8.342419e-02 -5.710335e-03  4.040688e-02
## PC.aa.C36.4_T4    -1.250613e-02  9.577756e-02 -6.300606e-02 -1.884866e-02
## PC.aa.C36.5_T4    -3.147602e-02  6.800822e-02 -2.056615e-02 -1.076283e-03
## PC.aa.C38.0_T4    -1.271027e-03  3.186359e-02  7.769639e-03  5.174960e-03
## PC.aa.C38.1_T4     1.431643e-02  1.496266e-02  1.484004e-03  3.358954e-03
## PC.aa.C38.3_T4    -4.019321e-02  1.009897e-01 -1.306164e-02  5.102613e-02
## PC.aa.C38.4_T4    -2.762959e-02  9.572786e-02 -3.111845e-02  1.860275e-02
## PC.aa.C38.5_T4    -2.445981e-02  1.092561e-01 -3.035773e-02 -1.520907e-02
## PC.aa.C38.6_T4    -3.976156e-02  1.161441e-01 -2.856020e-02 -2.705500e-02
## PC.aa.C40.1_T4     3.734444e-02  4.698770e-02  6.506392e-03  2.205278e-02
## PC.aa.C40.2_T4     2.635762e-02  1.129636e-03  3.073795e-03 -1.863949e-03
## PC.aa.C40.3_T4     2.113096e-02  2.412896e-03  9.991507e-04 -1.754358e-03
## PC.aa.C40.4_T4     2.783414e-02  2.153183e-02  8.284951e-03  6.439017e-03
## PC.aa.C40.5_T4    -6.780948e-03  5.739093e-02 -1.462312e-02  4.327099e-03
## PC.aa.C40.6_T4    -4.344218e-02  1.087207e-01 -1.447058e-02 -1.103246e-02
## PC.aa.C42.0_T4     6.296538e-03 -8.657984e-03 -3.562393e-03 -1.602326e-03
## PC.aa.C42.1_T4     6.544875e-03 -1.114046e-02 -3.810689e-03 -1.921457e-03
## PC.aa.C42.2_T4     1.236289e-02 -8.144499e-03 -4.522907e-04 -6.254228e-03
## PC.aa.C42.4_T4     1.430619e-02 -8.063084e-03  5.862469e-04 -4.519321e-03
## PC.aa.C42.5_T4     6.171514e-03 -7.397710e-03 -4.726447e-03 -3.228396e-03
## PC.aa.C42.6_T4     1.434618e-02  1.573248e-02 -9.302576e-03  3.748314e-02
## PC.ae.C30.0_T4     1.476514e-02  4.263130e-02  1.181647e-02  4.249945e-03
## PC.ae.C32.1_T4     1.118356e-02  3.837654e-03 -2.766908e-03 -6.171587e-03
## PC.ae.C32.2_T4     6.153218e-03 -6.410174e-03 -3.992508e-03 -5.453986e-03
## PC.ae.C34.0_T4     2.179413e-03 -1.218479e-02 -5.208531e-03 -5.132130e-03
## PC.ae.C34.1_T4    -2.327206e-04  3.447648e-02 -5.272682e-04 -8.623733e-03
## PC.ae.C34.2_T4     7.819869e-03  2.604721e-02  5.200774e-02  5.487904e-03
## PC.ae.C34.3_T4     1.518003e-02  1.510617e-02  3.798394e-02  4.350871e-03
## PC.ae.C36.0_T4     4.670864e-03 -6.028202e-03 -2.119175e-03 -7.292384e-03
## PC.ae.C36.1_T4     7.921180e-02  5.695052e-02  5.009061e-02 -3.983171e-02
## PC.ae.C36.2_T4     8.465069e-03  3.295427e-02  4.840333e-02  7.954082e-04
## PC.ae.C36.3_T4    -5.425292e-03  6.361628e-03  2.665651e-02  1.638287e-02
## PC.ae.C36.4_T4    -1.336785e-02  2.596308e-02  1.075799e-02  1.711794e-02
## PC.ae.C36.5_T4    -6.016467e-03  3.200970e-02  8.579059e-03  1.127039e-02
## PC.ae.C38.0_T4    -5.724563e-03  9.901465e-03 -1.501623e-03 -4.189372e-03
## PC.ae.C38.2_T4     7.826863e-02  3.701886e-02  3.787274e-02 -9.320256e-03
## PC.ae.C38.3_T4     6.469396e-02  4.091143e-02  1.543588e-02  3.876735e-03
## PC.ae.C38.4_T4    -2.321748e-03  2.000925e-02  6.869525e-03  6.784508e-03
## PC.ae.C38.5_T4    -1.349853e-02  3.611045e-02  6.419068e-03  1.618844e-02
## PC.ae.C38.6_T4    -1.652951e-02  2.068113e-02  1.173129e-02  5.346097e-03
## PC.ae.C40.1_T4     1.627970e-02  5.313140e-03  6.054934e-03  4.178487e-05
## PC.ae.C40.2_T4     2.914961e-02  1.233505e-02 -1.494000e-03 -5.972933e-03
## PC.ae.C40.3_T4     6.497773e-02  2.926602e-02  1.589755e-02  8.522216e-04
## PC.ae.C40.4_T4     4.842871e-02  2.006119e-02  1.564379e-02 -1.418520e-03
## PC.ae.C40.5_T4     6.573000e-02  3.924799e-02  2.030707e-02 -1.807145e-02
## PC.ae.C40.6_T4    -5.342771e-03  1.101446e-02  1.659878e-03 -4.951780e-03
## PC.ae.C42.1_T4     1.395189e-02 -4.227097e-03 -8.699923e-04 -1.324381e-04
## PC.ae.C42.2_T4     1.026979e-02 -8.269396e-03  1.884920e-04 -8.149770e-04
## PC.ae.C42.3_T4     2.066689e-02 -2.015175e-03  7.682697e-03 -7.274655e-03
## PC.ae.C42.4_T4     1.111241e-02 -1.055521e-02  6.923911e-03  1.121604e-03
## PC.ae.C42.5_T4     3.459445e-02  1.199763e-02  3.987607e-04 -1.645389e-02
## PC.ae.C44.3_T4     9.049013e-03 -1.192936e-02 -1.099771e-03 -5.020693e-03
## PC.ae.C44.4_T4     4.294970e-03 -1.532038e-02 -2.566633e-03 -4.929617e-03
## PC.ae.C44.5_T4     3.222760e-03 -1.434472e-02 -1.086216e-02 -4.559887e-03
## PC.ae.C44.6_T4     6.820969e-03 -2.018065e-02 -4.071994e-03  3.479071e-04
## SM..OH..C14.1_T4   6.848421e-03  3.621023e-03  3.348323e-03 -3.866911e-02
## SM..OH..C16.1_T4   3.716071e-03 -4.686472e-03 -1.134484e-02 -2.325436e-02
## SM..OH..C22.1_T4  -4.151286e-02 -2.791574e-03  1.215903e-02 -6.981507e-03
## SM..OH..C22.2_T4  -1.095592e-03  2.375439e-02  2.135809e-02 -2.696514e-02
## SM..OH..C24.1_T4  -2.392746e-03 -1.511789e-02 -6.669545e-03 -4.195342e-03
## SM.C16.0_T4       -1.278910e-02  6.332065e-02 -2.274655e-02 -3.649563e-02
## SM.C16.1_T4        1.136336e-02  4.342851e-02  2.267820e-03 -4.960311e-02
## SM.C18.0_T4        3.942216e-03  6.945102e-02 -8.990950e-02 -6.874163e-02
## SM.C18.1_T4        1.761095e-02  5.892245e-02 -3.208513e-02 -7.174301e-02
## SM.C20.2_T4        1.036226e-03 -1.361141e-02 -7.427236e-03 -3.264413e-03
## SM.C24.0_T4       -5.001151e-02  1.702962e-02  1.843063e-02  2.425378e-02
## SM.C24.1_T4       -2.457752e-02  8.751003e-02 -4.356497e-02 -2.877841e-02
## MEDDM_T5           1.541726e-03 -2.849761e-02 -2.993495e-03 -1.568098e-02
## MEDCOL_T5          1.541726e-03 -2.849761e-02 -2.993495e-03 -1.568098e-02
## MEDINF_T5          3.187324e-04 -2.830269e-02 -8.097097e-03 -1.609873e-02
## MEDHTA_T5          1.631254e-03 -2.884248e-02 -2.306314e-03 -2.553045e-02
## GLU_T5            -5.527453e-02 -2.476306e-02  4.620418e-02 -8.763713e-02
## INS_T5            -4.071259e-03 -7.052698e-03 -1.010909e-01 -1.985246e-02
## HOMA_T5           -6.458594e-03 -1.875732e-02 -3.615516e-02 -1.173150e-02
## HBA1C_T5          -4.985002e-03 -6.739199e-02  3.365910e-02 -3.980743e-02
## HBA1C.mmol.mol_T5 -1.389622e-02 -9.161159e-02  8.775688e-02 -7.883002e-02
## PESO_T5           -2.179200e-02 -1.743265e-02 -8.966485e-02 -2.569118e-02
## bmi_T5            -2.150532e-02  6.569099e-04 -5.662520e-02 -3.639503e-02
## CC_T5              7.249484e-05 -2.415086e-02 -3.209995e-03 -4.924151e-03
## CINT_T5           -2.481676e-02  9.062593e-03 -6.193861e-02 -2.112038e-02
## CAD_T5            -2.543660e-02  1.344483e-02 -3.063541e-02 -8.651131e-02
## TAD_T5            -9.652439e-03 -6.385695e-02  6.541223e-02 -4.907469e-02
## TAS_T5            -5.731885e-04 -8.874218e-02  5.653855e-02 -5.204994e-03
## TG_T5             -5.063651e-02  9.927692e-02 -2.358428e-02 -9.542054e-02
## COL_T5            -6.630115e-02  7.337893e-02  8.637781e-02 -7.195214e-02
## LDL_T5            -5.459825e-02  7.575803e-02  5.339063e-02 -5.157834e-02
## HDL_T5            -2.128401e-02  1.008567e-02  1.538598e-01 -5.010872e-02
## VLDL_T5           -3.610009e-02  7.916395e-02 -4.088093e-02 -5.943094e-02
## PCR_T5            -5.089461e-02  8.309171e-03 -1.656186e-02 -8.089484e-03
## LEP_T5            -4.461574e-02  3.865464e-02 -4.633159e-03 -7.178361e-02
## ADIPO_T5           8.287738e-02 -1.397499e-02  1.188456e-01 -1.440083e-01
## GOT_T5             7.650004e-02 -4.735164e-02  2.626216e-02 -3.511994e-02
## GPT_T5             3.879732e-02 -7.825684e-02 -4.833914e-02 -4.640349e-02
## GGT_T5             1.371071e-02  4.304554e-02 -1.870616e-02 -1.201446e-02
## URICO_T5           1.750099e-03 -1.531693e-02 -4.368160e-02 -1.074753e-02
## CREAT_T5           1.526487e-04 -1.710771e-02 -8.572132e-03 -1.079947e-02
## UREA_T5            1.438625e-03 -2.261755e-02  7.992962e-02  4.763995e-02
## HIERRO_T5          2.410971e-03 -8.427796e-02  6.709630e-02 -2.060320e-03
## TRANSF_T5         -4.065783e-02  3.554980e-02  3.069176e-02 -6.478675e-03
## FERR_T5            7.311036e-03 -8.570257e-02 -4.028338e-02 -2.009189e-02
## Ile_T5             6.129890e-02 -1.666252e-02 -5.840193e-02  6.039952e-02
## Leu_T5             6.038558e-02 -4.559871e-02 -7.763930e-03  6.181194e-02
## Val_T5             4.059724e-02 -3.210582e-02 -4.171412e-03  7.112565e-02
## Ala_T5             3.978706e-02  1.317591e-02 -4.460490e-03 -2.495122e-03
## Pro_T5             6.525215e-02 -2.058756e-02 -2.213686e-02  3.287735e-02
## Gly_T5             6.657912e-02  1.914752e-02  4.520885e-02 -4.569807e-03
## Ser_T5             7.261378e-02 -2.481652e-02 -5.150885e-03 -4.236959e-02
## Trp_T5             8.324534e-03 -5.162927e-02  1.447775e-02  1.236680e-01
## Phe_T5             7.489163e-02 -1.366845e-02  2.949598e-02  2.778611e-02
## Met_T5            -1.800008e-02 -7.305444e-02 -2.840993e-02  8.711630e-02
## Orn_T5             1.019141e-01 -4.146962e-03  8.377865e-02  5.465269e-02
## Arg_T5             4.046660e-02  4.062245e-03  5.737180e-03  3.295377e-02
## His_T5             8.287990e-02 -2.552736e-02  3.708990e-02 -2.721187e-02
## Asn_T5             8.112528e-02 -3.836674e-02 -1.530230e-02  7.068078e-03
## Asp_T5             9.374592e-02  5.220115e-02  1.615056e-02  8.300922e-02
## Glu_T5             5.834101e-02  4.788402e-02  7.269412e-03  3.781849e-02
## Gln_T5             4.361097e-02 -6.386021e-02 -3.539830e-02 -1.811416e-02
## Cit_T5             1.036185e-01 -1.999110e-02  3.933326e-02  1.879824e-02
## Tyr_T5             7.664697e-02 -2.220519e-02  2.846423e-02  4.788779e-02
## Thr_T5             9.804510e-03 -2.324482e-02  1.268395e-02  6.584655e-02
## Lys_T5             1.077291e-02  1.167722e-02  1.186584e-02  5.304529e-02
## Creatinine_T5      2.462916e-02 -1.123241e-01 -7.763835e-02 -3.300848e-02
## Kynurenine_T5     -8.851449e-03 -7.068805e-03 -3.525099e-02  1.367677e-01
## Putrescine_T5     -2.499126e-02  3.659217e-03 -1.232352e-01 -6.563615e-03
## Sarcosine_T5      -1.309200e-03 -8.511145e-02 -7.574182e-02 -3.427045e-02
## Serotonin_T5       5.082634e-03 -6.754399e-03 -5.106285e-02 -4.064373e-02
## Taurine_T5         4.741507e-02 -4.708094e-02  1.418005e-02  2.091455e-02
## SDMA_T5            3.343762e-03 -2.072065e-02 -9.211640e-03 -2.264523e-03
## C0_T5              3.783909e-02 -2.135769e-02 -3.198523e-02  5.584267e-02
## C2_T5              1.585730e-02 -4.506457e-02 -2.991364e-02  5.162807e-03
## C3.OH_T5           7.224460e-04 -1.768228e-02 -4.798772e-03 -4.062188e-03
## C6..C4.1.DC._T5   -1.463326e-02 -3.892352e-02 -6.236010e-03  1.037224e-01
## C5.DC..C6.OH._T5   3.343447e-03 -1.516615e-02 -3.034681e-02 -2.334195e-02
## C7.DC_T5          -9.757712e-03  1.446298e-02  3.266875e-02 -4.915976e-02
## C8_T5              1.766735e-03 -2.036470e-02 -6.958868e-03 -4.334618e-03
## C10_T5             3.071888e-03 -2.052322e-02 -7.761144e-03 -5.174210e-03
## C10.1_T5           6.500279e-02 -2.494447e-02 -1.048334e-02  2.953837e-02
## C10.2_T5           6.744042e-04 -1.788651e-02 -5.670678e-03 -3.795668e-03
## C14.1_T5           1.246695e-03 -1.786041e-02 -5.143623e-03 -3.082646e-03
## C14.2_T5           1.016741e-03 -1.776352e-02 -5.281143e-03 -3.498403e-03
## C16.1_T5           5.211026e-04 -1.722812e-02 -5.016716e-03 -3.038556e-03
## C16.2_T5           5.672111e-04 -1.686587e-02 -5.538483e-03 -3.032647e-03
## C16.2.OH_T5        1.053338e-02 -2.164978e-02 -2.190764e-02  2.292170e-02
## C18.1_T5           1.956490e-03 -1.704430e-02 -5.771966e-03 -3.042850e-03
## C18.1.OH_T5        4.442292e-04 -1.668763e-02 -5.399711e-03 -2.942755e-03
## C18.2_T5           9.834848e-04 -1.718802e-02 -5.762315e-03 -2.680992e-03
## lysoPC.a.C16.0_T5  7.080223e-02  3.813469e-03 -4.165594e-02 -3.730536e-02
## lysoPC.a.C16.1_T5  6.900519e-02 -1.341190e-02 -1.066626e-02 -6.450577e-02
## lysoPC.a.C17.0_T5  2.487366e-02 -2.280832e-02  6.208461e-03 -1.254888e-02
## lysoPC.a.C18.0_T5  7.257095e-02  2.097141e-02  1.917232e-02 -9.816001e-03
## lysoPC.a.C18.1_T5  8.201356e-02 -1.183655e-03 -3.310276e-02 -5.780339e-02
## lysoPC.a.C18.2_T5  7.123098e-02 -5.169550e-02 -5.141749e-02 -1.626370e-02
## lysoPC.a.C20.3_T5  3.758766e-02 -1.500908e-02 -4.541578e-02 -1.344349e-02
## lysoPC.a.C20.4_T5  5.087245e-02 -2.825781e-02 -9.560753e-02 -1.624428e-02
## lysoPC.a.C24.0_T5  5.029244e-03 -1.724646e-02 -1.178378e-03 -6.888565e-03
## lysoPC.a.C26.0_T5  1.097507e-02 -1.018114e-02 -1.067626e-03 -8.000479e-03
## lysoPC.a.C26.1_T5  3.042777e-03 -1.463654e-02 -5.990520e-03 -3.808208e-03
## lysoPC.a.C28.0_T5  3.751754e-02  2.688244e-02  4.180641e-02  6.088762e-02
## lysoPC.a.C28.1_T5  4.852821e-03 -1.441850e-02 -3.722307e-03 -5.420191e-03
## PC.aa.C24.0_T5     1.902667e-02  1.029317e-01  5.592628e-03  2.327887e-02
## PC.aa.C28.1_T5     3.609349e-03 -1.163538e-02  6.425658e-03  1.036317e-02
## PC.aa.C30.0_T5     2.100091e-03 -9.604424e-03 -9.927398e-03  4.992370e-04
## PC.aa.C32.0_T5     4.776583e-02  1.800694e-02 -5.971899e-02  4.332068e-03
## PC.aa.C32.1_T5     3.429672e-02  3.630285e-02  1.533203e-03 -5.482252e-02
## PC.aa.C32.3_T5     1.614148e-03 -1.547499e-02 -4.610883e-03 -3.613500e-03
## PC.aa.C34.1_T5     2.761893e-02  5.089718e-02 -1.950930e-02 -3.673821e-02
## PC.aa.C34.2_T5     1.135867e-02  3.844365e-02 -1.530700e-02  1.639475e-02
## PC.aa.C34.3_T5     1.254723e-02  3.725922e-02 -8.986230e-04  1.708291e-03
## PC.aa.C34.4_T5     3.564734e-04 -1.414360e-02 -6.706927e-03  7.095643e-04
## PC.aa.C36.0_T5     1.467368e-02  1.637358e-03  9.001790e-03 -9.223767e-03
## PC.aa.C36.1_T5     4.375246e-02  3.868550e-02  6.665434e-02  2.779955e-02
## PC.aa.C36.2_T5     1.135660e-02  3.634538e-02  3.571460e-02  5.005929e-02
## PC.aa.C36.3_T5     7.302783e-03  3.804636e-02 -1.758279e-02  3.697830e-02
## PC.aa.C36.4_T5    -4.911345e-03  3.422378e-02 -7.179767e-02  3.182023e-02
## PC.aa.C36.5_T5    -2.951559e-02  1.929588e-02 -5.366847e-02  1.963963e-03
## PC.aa.C38.0_T5     7.425625e-03  8.548694e-03  1.915956e-02  1.425086e-03
## PC.aa.C38.1_T5     2.500377e-02 -6.390971e-03  1.614475e-02 -1.185600e-02
## PC.aa.C38.3_T5     8.581703e-03  5.881153e-02 -5.618626e-03  7.608727e-02
## PC.aa.C38.4_T5    -1.115337e-03  4.528570e-02 -2.464253e-02  5.377187e-02
## PC.aa.C38.5_T5    -2.278655e-03  4.950092e-02 -4.418336e-02  7.951087e-03
## PC.aa.C38.6_T5    -3.171722e-02  5.052549e-02 -4.403237e-02  9.278388e-03
## PC.aa.C40.1_T5     5.057646e-02  5.337592e-02  3.727134e-02  7.253678e-02
## PC.aa.C40.2_T5     2.390378e-02 -3.401774e-03  8.249943e-03 -1.236759e-02
## PC.aa.C40.3_T5     2.484305e-02 -3.321701e-03  9.327076e-03 -1.591358e-02
## PC.aa.C40.4_T5     2.942227e-02  1.020356e-02  3.484427e-03 -5.326501e-03
## PC.aa.C40.5_T5     1.472309e-02  2.495197e-02 -9.886069e-03 -3.718390e-03
## PC.aa.C40.6_T5    -2.198015e-02  5.577399e-02 -2.221719e-02  3.176114e-02
## PC.aa.C42.0_T5     5.582795e-03 -1.524493e-02 -1.339190e-03 -2.416744e-03
## PC.aa.C42.1_T5     4.445405e-03 -1.500554e-02 -2.067898e-03 -3.272964e-03
## PC.aa.C42.2_T5     1.134628e-02 -1.060588e-02  1.387126e-03 -9.011786e-03
## PC.aa.C42.4_T5     1.436200e-02 -9.078345e-03  1.910065e-03 -8.276968e-03
## PC.aa.C42.5_T5     8.337280e-03 -1.023938e-02 -3.132676e-03 -5.857119e-03
## PC.aa.C42.6_T5     3.059907e-02  1.772433e-02  3.327346e-02  4.770274e-02
## PC.ae.C30.0_T5     4.123809e-02  2.551173e-03  3.011578e-03  6.151764e-02
## PC.ae.C32.1_T5     1.464275e-02 -1.881502e-02  4.605090e-03 -3.990791e-03
## PC.ae.C32.2_T5     6.155085e-03 -1.396863e-02  5.778248e-04 -4.532878e-03
## PC.ae.C34.0_T5     4.204792e-03 -1.549245e-02 -3.383304e-03 -3.448050e-04
## PC.ae.C34.1_T5     1.500118e-02  4.682033e-03  1.869484e-02  1.162104e-03
## PC.ae.C34.2_T5     2.976525e-02 -3.134157e-03  5.747666e-02  1.428608e-02
## PC.ae.C34.3_T5     3.032804e-02 -4.137577e-04  3.366499e-02  4.786173e-03
## PC.ae.C36.0_T5     1.012804e-02 -1.211150e-02 -1.481114e-04 -4.683142e-03
## PC.ae.C36.1_T5     8.529050e-02  3.366812e-02  5.841114e-02 -3.737904e-02
## PC.ae.C36.2_T5     3.312514e-02  1.130067e-02  5.109737e-02  4.222601e-03
## PC.ae.C36.3_T5     1.091268e-02 -1.171201e-02  2.730497e-02  1.009591e-02
## PC.ae.C36.4_T5     1.211299e-02 -4.213648e-04  5.323768e-03  4.557527e-02
## PC.ae.C36.5_T5     9.455720e-03  9.487964e-03 -4.751863e-03  1.461187e-02
## PC.ae.C38.0_T5    -3.775928e-04 -7.523064e-03 -4.925656e-03 -1.442187e-03
## PC.ae.C38.2_T5     7.961989e-02  2.653794e-02  5.121811e-02 -3.425456e-02
## PC.ae.C38.3_T5     5.944123e-02  2.164338e-02  1.715554e-02  9.669008e-03
## PC.ae.C38.4_T5     2.808046e-03 -5.103262e-03  6.818595e-03  3.817361e-02
## PC.ae.C38.5_T5    -5.304074e-04  4.184585e-03 -1.701410e-02  4.579457e-02
## PC.ae.C38.6_T5    -5.422127e-03  2.228251e-03  4.434281e-04  1.316128e-02
## PC.ae.C40.1_T5     1.752307e-02 -5.276469e-03  6.689195e-04 -9.876361e-03
## PC.ae.C40.2_T5     3.109212e-02  2.143312e-03  7.229232e-03 -7.645975e-03
## PC.ae.C40.3_T5     6.101128e-02  2.036306e-02  1.588517e-02  2.419691e-03
## PC.ae.C40.4_T5     4.657417e-02  4.679170e-03  2.518755e-02  2.294853e-03
## PC.ae.C40.5_T5     5.827443e-02  1.581681e-02  9.322981e-03  2.320437e-03
## PC.ae.C40.6_T5    -1.353030e-05 -1.138217e-02 -5.227260e-03  5.994736e-03
## PC.ae.C42.1_T5     1.483743e-02 -7.959172e-03  6.368443e-05 -6.763585e-03
## PC.ae.C42.2_T5     1.296022e-02 -1.149058e-02  1.594072e-03 -7.583493e-03
## PC.ae.C42.3_T5     2.042069e-02 -6.966034e-03  8.290229e-03 -8.830890e-03
## PC.ae.C42.4_T5     1.466883e-02 -1.394389e-02  6.450968e-03 -1.856290e-03
## PC.ae.C42.5_T5     3.683359e-02 -6.289557e-03  6.145650e-03  1.283623e-02
## PC.ae.C44.3_T5     9.591082e-03 -1.242455e-02 -3.536827e-04 -7.342401e-03
## PC.ae.C44.4_T5     5.611252e-03 -1.649394e-02  1.922577e-04 -2.873987e-03
## PC.ae.C44.5_T5     2.671604e-03 -2.647666e-02 -2.356225e-03  1.437847e-02
## PC.ae.C44.6_T5     6.367906e-03 -2.830281e-02 -2.654624e-03  1.196712e-02
## SM..OH..C14.1_T5   5.134371e-03 -1.587543e-02  1.221979e-02  6.846117e-05
## SM..OH..C16.1_T5   1.238687e-03 -1.691769e-02 -5.327015e-03 -1.637048e-03
## SM..OH..C22.1_T5  -2.926439e-02  1.590346e-02  1.561327e-02  3.755648e-02
## SM..OH..C22.2_T5  -3.646292e-03  1.614545e-02  2.483269e-02  2.874542e-02
## SM..OH..C24.1_T5  -1.647480e-03 -1.615893e-02 -5.033890e-03  1.526793e-03
## SM.C16.0_T5        9.260947e-03  3.082699e-02 -3.813692e-02  2.319293e-02
## SM.C16.1_T5        2.088881e-02  6.418725e-03 -4.246977e-03  2.389299e-02
## SM.C18.0_T5        2.338297e-03  1.698358e-02 -1.131566e-01 -1.020511e-03
## SM.C18.1_T5        1.268094e-02  2.386554e-05 -5.257770e-02 -6.577657e-03
## SM.C20.2_T5        2.555965e-04 -1.638825e-02 -8.379642e-03 -2.673729e-03
## SM.C24.0_T5       -2.272492e-02  4.159004e-02 -7.619512e-04  3.837586e-02
## SM.C24.1_T5        3.476208e-03  3.909833e-02 -7.438568e-02  1.825088e-02
##                             PC9          PC10          PC11          PC12
## GLU_T0             2.438452e-02  1.566445e-01 -4.372887e-02  0.0011411416
## INS_T0             1.184253e-02  8.319994e-02  2.652871e-03 -0.0733849937
## HOMA_T0            3.823989e-03  8.110610e-02 -9.874944e-03 -0.0358306318
## HBA1C_T0          -1.177425e-02  1.898548e-03  1.669542e-02 -0.0205642309
## HBA1C.mmol.mol_T0 -1.407810e-02  6.920943e-03  3.176609e-02 -0.0459906567
## PESO_T0            3.890771e-02  6.941303e-02 -2.343311e-02 -0.0275387049
## bmi_T0             3.080049e-02 -9.919143e-03 -4.904091e-02 -0.0080915758
## CC_T0              2.226370e-03  1.272202e-02  6.092447e-03 -0.0015101419
## CINT_T0            4.588102e-02  7.945161e-02  1.348185e-02 -0.0298353579
## CAD_T0             3.684231e-02  4.255537e-03  8.382336e-03 -0.0379595877
## TAD_T0            -2.067237e-02 -2.303461e-02  2.661606e-02  0.0410332013
## TAS_T0            -3.590976e-02 -8.087202e-04 -2.106133e-02  0.0555980575
## TG_T0             -3.087772e-02  4.398666e-03  5.465659e-02 -0.0269775481
## COL_T0             4.909724e-02  1.136076e-01 -5.689940e-02 -0.0587275521
## LDL_T0             7.350369e-02  9.894287e-02 -6.425331e-02 -0.0261281662
## HDL_T0            -2.763510e-02  6.424031e-02 -1.577859e-03 -0.0382009746
## VLDL_T0           -3.142117e-02  4.394110e-03  5.604014e-02 -0.0268912269
## PCR_T0            -5.438458e-02 -1.818322e-02 -1.701929e-02  0.0066885346
## LEP_T0             3.243940e-02  8.085803e-03 -1.464749e-02  0.0451618844
## ADIPO_T0           2.705243e-02  9.432527e-02  4.728377e-02 -0.0598368878
## GOT_T0             4.412787e-02  1.216938e-01  9.602560e-03  0.1195336419
## GPT_T0             2.567755e-02  1.458978e-01 -6.485978e-02  0.0588308400
## GGT_T0             8.337893e-03  9.089830e-02 -5.241746e-02 -0.0369032701
## URICO_T0           2.206514e-02  5.224728e-02  8.756666e-03 -0.0183215461
## CREAT_T0           1.669129e-04  1.252453e-02  1.380460e-03 -0.0017000046
## UREA_T0            1.003705e-01  1.401143e-01  1.664338e-02  0.0387527116
## HIERRO_T0          1.580885e-02  9.101780e-02 -6.653866e-02 -0.0965712555
## TRANSF_T0          3.419223e-02 -2.891149e-02 -5.468015e-03  0.0077835440
## FERR_T0           -3.973643e-02  1.150497e-01  2.706092e-02  0.0529335138
## Ile_T0             9.714631e-03  3.195125e-02  3.548193e-02 -0.0784626187
## Leu_T0             1.715408e-02  3.827818e-02  6.259876e-02 -0.0614262919
## Val_T0             3.354803e-02  2.610879e-02  5.710035e-02 -0.0330814993
## Ala_T0             4.255389e-02 -4.268654e-02  1.958970e-02 -0.0162419783
## Pro_T0             7.449581e-03 -5.826336e-02 -5.016666e-02 -0.0728170160
## Gly_T0             2.899142e-02 -7.114528e-02 -8.053249e-02  0.0824415977
## Ser_T0             9.080881e-02 -5.795801e-02  2.589640e-02  0.0177973175
## Trp_T0             3.092291e-03 -3.051119e-02 -1.147493e-02 -0.0593995380
## Phe_T0             5.006890e-02 -4.229088e-02  6.253676e-02 -0.0759304170
## Met_T0            -1.787007e-02 -3.264462e-02 -1.073945e-02 -0.0124652071
## Orn_T0             5.396143e-02 -9.152832e-02 -4.525014e-02  0.0342398428
## Arg_T0             3.893213e-03 -3.853434e-02  8.349294e-03 -0.0542870877
## His_T0             3.311645e-02 -3.783414e-02  2.667074e-03 -0.0074564206
## Asn_T0            -6.447793e-04 -7.022776e-02  4.598260e-02 -0.0387297410
## Asp_T0             5.205696e-02 -9.000165e-03  7.080223e-02 -0.0027085193
## Glu_T0             6.328748e-03  3.259883e-02 -3.338263e-03 -0.0180519533
## Gln_T0             1.752337e-02 -4.199215e-02 -7.537963e-02  0.0236704461
## Cit_T0             2.048357e-02 -3.828404e-02 -6.401562e-02  0.0119408129
## Tyr_T0             4.656140e-02 -5.165183e-03 -4.602666e-02 -0.0290117151
## Thr_T0            -4.020490e-03 -1.891177e-01  8.955926e-02 -0.0349854585
## Lys_T0             5.415181e-02 -5.341548e-02 -4.635663e-03 -0.0229300537
## Creatinine_T0      4.199168e-04  6.992753e-02 -3.718438e-02  0.0106878588
## Kynurenine_T0      7.045162e-03 -1.758450e-02 -1.133900e-02  0.0185493986
## Putrescine_T0     -4.498463e-02 -4.222731e-02 -5.938579e-02 -0.0791321129
## Sarcosine_T0       8.238727e-02  1.190373e-03 -8.262403e-03 -0.0363316116
## Serotonin_T0       2.137453e-03  5.210545e-02  3.048434e-02 -0.0700331395
## Taurine_T0         1.168160e-01 -8.913214e-03  6.970391e-02  0.0786319497
## SDMA_T0            3.129001e-03  2.935570e-03 -2.498528e-03  0.0010150726
## C0_T0              2.522264e-02  1.451991e-02 -7.608140e-02  0.0040093251
## C2_T0             -7.703068e-03  4.628583e-02 -4.883553e-02  0.0698138643
## C3.OH_T0          -8.229066e-04 -4.331127e-04  4.626461e-03 -0.0001621719
## C6..C4.1.DC._T0    6.613895e-02 -8.018376e-03  7.753703e-02  0.0285756020
## C5.DC..C6.OH._T0  -1.936501e-02 -3.520575e-02 -4.000415e-02  0.0104659989
## C7.DC_T0          -5.297089e-02 -2.337867e-03  6.483862e-03 -0.0431429736
## C8_T0             -4.018189e-03  1.315918e-03  3.441526e-03  0.0016369018
## C10_T0            -1.189032e-03 -9.512684e-04  2.073752e-03 -0.0012961270
## C10.1_T0          -1.675055e-03 -4.256642e-04  4.915413e-03  0.0001980352
## C10.2_T0           4.375004e-04 -2.949667e-04  5.114624e-03  0.0015851432
## C14.1_T0          -1.302469e-03  1.079755e-03  3.161211e-03  0.0020159229
## C14.2_T0          -8.302591e-04  2.098108e-04  4.375547e-03  0.0004363813
## C16.1_T0          -9.019826e-04  3.333817e-04  4.200210e-03  0.0013036524
## C16.2_T0          -1.488416e-03  1.346483e-04  5.072529e-03  0.0011937387
## C16.2.OH_T0       -1.597754e-03  5.810142e-05  4.577058e-03  0.0011110285
## C18.1_T0           2.370344e-04  4.841495e-04  2.668645e-03  0.0033654899
## C18.1.OH_T0       -1.265610e-03 -2.457760e-04  5.206536e-03  0.0013025119
## C18.2_T0          -4.375405e-04  4.393503e-04  4.163872e-03  0.0007574662
## lysoPC.a.C16.0_T0  2.952183e-02 -9.151482e-03  1.950465e-03  0.0018750756
## lysoPC.a.C16.1_T0  9.804633e-03 -1.591580e-02 -1.064637e-02  0.0134362415
## lysoPC.a.C17.0_T0  3.074221e-02  1.165314e-02  7.607259e-03  0.0122885026
## lysoPC.a.C18.0_T0  5.276709e-02  5.532772e-03 -1.292071e-02  0.0034371271
## lysoPC.a.C18.1_T0  5.647095e-02  6.249979e-03 -4.035763e-02  0.0299229016
## lysoPC.a.C18.2_T0  5.771512e-02 -1.249026e-02 -1.159836e-02 -0.0478989673
## lysoPC.a.C20.3_T0  2.024000e-02 -2.110278e-02  1.341915e-02 -0.0138092960
## lysoPC.a.C20.4_T0  5.429436e-02 -9.571835e-03 -5.333094e-02  0.0305718464
## lysoPC.a.C24.0_T0  1.683707e-03  3.982614e-03  2.888444e-03  0.0030942051
## lysoPC.a.C26.0_T0  1.142585e-02 -2.043052e-02 -2.291047e-02  0.0092098645
## lysoPC.a.C26.1_T0 -8.536606e-04  2.172839e-04  2.711270e-03  0.0022013004
## lysoPC.a.C28.0_T0  5.415131e-02 -5.602505e-02  5.623046e-03 -0.0049046401
## lysoPC.a.C28.1_T0  4.221111e-03  5.483069e-03  3.155003e-03  0.0051117391
## PC.aa.C24.0_T0    -2.370547e-02 -7.568416e-02 -4.140068e-02  0.1001484003
## PC.aa.C28.1_T0     1.433741e-02 -1.574586e-02 -3.609275e-03 -0.0020953317
## PC.aa.C30.0_T0    -5.517825e-03  5.867289e-04  2.102904e-02 -0.0111722717
## PC.aa.C32.0_T0    -7.125569e-02  1.235553e-02 -9.650078e-03  0.0192225755
## PC.aa.C32.1_T0    -7.477015e-02 -3.052369e-02  5.952072e-02 -0.0094079819
## PC.aa.C32.3_T0    -2.544614e-03 -1.197704e-03  6.434538e-03  0.0032198141
## PC.aa.C34.1_T0    -6.521834e-02  1.032839e-02 -1.764965e-02  0.0264169199
## PC.aa.C34.2_T0    -9.417528e-02 -9.981003e-03  1.192865e-01 -0.0588832164
## PC.aa.C34.3_T0    -2.675132e-02 -2.877577e-02  5.858419e-02 -0.0309529646
## PC.aa.C34.4_T0    -1.842264e-04 -5.941290e-03  1.748494e-02  0.0005875088
## PC.aa.C36.0_T0     4.355774e-03  1.614224e-02  2.485147e-02  0.0028001971
## PC.aa.C36.1_T0     1.822949e-02 -1.081130e-02 -2.947106e-02  0.0323889882
## PC.aa.C36.2_T0    -9.126208e-03 -6.798199e-03  2.489167e-02 -0.0371985333
## PC.aa.C36.3_T0    -4.365393e-02 -3.021804e-02  9.277189e-02 -0.0503029036
## PC.aa.C36.4_T0    -4.239864e-02 -1.748278e-02  2.365256e-03  0.0401675619
## PC.aa.C36.5_T0    -2.114021e-02  6.598235e-02  7.518126e-02  0.1085964277
## PC.aa.C38.0_T0     1.355538e-02  1.537954e-02  2.712888e-02  0.0327262647
## PC.aa.C38.1_T0     4.764418e-02  2.274842e-03  2.995523e-02  0.0644095041
## PC.aa.C38.3_T0    -1.727412e-03 -1.510051e-02  1.070440e-02 -0.0231376372
## PC.aa.C38.4_T0     1.734799e-02 -1.567909e-02 -6.460058e-02  0.0480786275
## PC.aa.C38.5_T0    -7.951134e-03  8.587592e-03 -3.954710e-02  0.0814483467
## PC.aa.C38.6_T0    -3.630422e-02  5.637563e-02  9.206512e-02  0.0920466975
## PC.aa.C40.1_T0     1.136515e-02 -6.965453e-02  4.466369e-02  0.0255149472
## PC.aa.C40.2_T0     7.325809e-04  8.216582e-03  1.826894e-03  0.0005781338
## PC.aa.C40.3_T0     9.536780e-04  1.045175e-02  1.729133e-03  0.0020497739
## PC.aa.C40.4_T0     1.618590e-03  1.931190e-03 -1.298123e-02 -0.0011867244
## PC.aa.C40.5_T0     8.379472e-03 -3.490584e-03 -2.318493e-02  0.0089595565
## PC.aa.C40.6_T0     3.624991e-04  7.298149e-02  5.257308e-02  0.1255662350
## PC.aa.C42.0_T0     1.267314e-03  7.067169e-03  3.931522e-03  0.0079873705
## PC.aa.C42.1_T0     2.842658e-04  4.958987e-03  4.880249e-03  0.0040170308
## PC.aa.C42.2_T0     2.255935e-03  7.844077e-03  6.074108e-03  0.0027357295
## PC.aa.C42.4_T0    -1.472881e-03  2.275456e-03  4.388978e-03  0.0032091634
## PC.aa.C42.5_T0    -1.274033e-03  3.942851e-03  5.976009e-03  0.0041176892
## PC.aa.C42.6_T0    -2.334212e-02 -7.500383e-03 -1.209203e-02  0.0141781417
## PC.ae.C30.0_T0    -4.943242e-04  1.490677e-03  5.369465e-03  0.0013963966
## PC.ae.C32.1_T0    -1.636935e-02  3.128040e-03 -7.280748e-03 -0.0129938734
## PC.ae.C32.2_T0    -3.009282e-03  2.700478e-03  2.619852e-03  0.0041373636
## PC.ae.C34.0_T0     1.782242e-03  4.001094e-03  7.452979e-03  0.0045768555
## PC.ae.C34.1_T0     3.504717e-03  4.608150e-03 -1.192594e-02  0.0160042828
## PC.ae.C34.2_T0     7.022528e-03 -9.633279e-03  3.374992e-02 -0.0542376956
## PC.ae.C34.3_T0     1.759964e-03  8.646178e-03  1.453944e-02 -0.0390958436
## PC.ae.C36.0_T0     2.511810e-03  1.004379e-02  2.534522e-03  0.0073115957
## PC.ae.C36.1_T0     1.460929e-02  2.380984e-02 -1.675301e-03  0.0014039384
## PC.ae.C36.2_T0     2.622372e-02  3.295569e-02  3.914351e-02  0.0032068335
## PC.ae.C36.3_T0     7.390643e-03 -1.776337e-02  1.389654e-02 -0.0272429216
## PC.ae.C36.4_T0     1.433152e-03 -3.786745e-02 -2.220332e-02 -0.0408082383
## PC.ae.C36.5_T0    -1.430431e-02 -5.625388e-03 -1.031319e-02 -0.0051490795
## PC.ae.C38.0_T0    -6.650855e-04  8.698859e-03  2.565479e-02  0.0192403984
## PC.ae.C38.2_T0     3.529208e-03  1.178361e-02  6.063624e-03  0.0067734282
## PC.ae.C38.3_T0    -5.857545e-03  1.328929e-02 -1.316389e-02 -0.0103970992
## PC.ae.C38.4_T0     2.632344e-02 -2.344048e-02 -2.749089e-02 -0.0042413289
## PC.ae.C38.5_T0     9.085294e-03 -3.257597e-02 -7.211317e-02  0.0079272112
## PC.ae.C38.6_T0     3.029811e-03 -8.265778e-03  1.892851e-02  0.0171124478
## PC.ae.C40.1_T0     4.990820e-03  1.413786e-02  1.158104e-02  0.0069045360
## PC.ae.C40.2_T0     5.060404e-03  1.187921e-02  1.975034e-03  0.0120109428
## PC.ae.C40.3_T0    -1.158306e-02  8.218780e-03 -1.497619e-02 -0.0059401797
## PC.ae.C40.4_T0    -8.715934e-04  1.237714e-03 -1.353653e-02  0.0016546849
## PC.ae.C40.5_T0    -1.559573e-03  4.185351e-03 -1.851578e-02  0.0070963923
## PC.ae.C40.6_T0     6.496662e-03  1.251684e-02  1.253491e-02  0.0268623443
## PC.ae.C42.1_T0     1.420075e-03  8.505136e-03  3.505950e-03  0.0015166277
## PC.ae.C42.2_T0     5.969172e-03  8.676059e-03  5.429485e-03  0.0025691465
## PC.ae.C42.3_T0     5.230356e-03  1.031070e-02  7.538531e-03  0.0071826508
## PC.ae.C42.4_T0    -5.092435e-04  4.642052e-04  2.317941e-03 -0.0004316179
## PC.ae.C42.5_T0    -1.835085e-03  6.738746e-03 -1.932829e-02  0.0109449010
## PC.ae.C44.3_T0    -6.174146e-04  2.184672e-03  5.447010e-03  0.0030380544
## PC.ae.C44.4_T0    -2.536603e-04  1.947117e-03  7.210890e-03  0.0022865689
## PC.ae.C44.5_T0     1.028352e-02  6.216483e-03 -1.347160e-02  0.0108280937
## PC.ae.C44.6_T0     2.009489e-03  4.229734e-03  6.993864e-04  0.0074084055
## SM..OH..C14.1_T0   3.217281e-02  1.866019e-02  8.742795e-04  0.0253016283
## SM..OH..C16.1_T0   1.427308e-02  1.092237e-02 -2.176544e-03  0.0146051251
## SM..OH..C22.1_T0   4.601709e-02  1.686346e-03  3.999732e-02 -0.0024603102
## SM..OH..C22.2_T0   4.591399e-02  2.460958e-02  4.396110e-03  0.0255602683
## SM..OH..C24.1_T0   5.169412e-03  3.576971e-03  4.772324e-03  0.0020432097
## SM.C16.0_T0        3.023888e-02  2.527331e-03 -7.891104e-02  0.0098137398
## SM.C16.1_T0        3.089070e-02 -1.398498e-02 -4.848559e-02  0.0417026555
## SM.C18.0_T0       -1.202560e-02  3.421147e-02 -6.737069e-02  0.0269109807
## SM.C18.1_T0        9.935133e-03  5.650201e-03 -5.749871e-02  0.0423722595
## SM.C20.2_T0       -2.204906e-03  2.889194e-04  5.498236e-03  0.0026832657
## SM.C24.0_T0        2.590007e-02  1.812651e-02  1.379958e-02 -0.0549488414
## SM.C24.1_T0        3.172821e-02  6.053888e-02 -6.070472e-02  0.0211836450
## MEDDM_T2          -1.749600e-03 -2.207597e-04  5.514135e-03  0.0016886642
## MEDCOL_T2         -1.749600e-03 -2.207597e-04  5.514135e-03  0.0016886642
## MEDINF_T2          1.073802e-02 -2.169181e-03  5.499598e-03  0.0096684667
## MEDHTA_T2          2.744333e-03 -2.493038e-03  3.551650e-03  0.0105892151
## GLU_T2            -8.040464e-02 -1.534454e-03 -3.645192e-02 -0.0826727365
## INS_T2            -1.455470e-03  1.058576e-01  2.636846e-02  0.0166082812
## HOMA_T2           -1.721233e-02  5.896013e-02  9.024573e-03 -0.0029057547
## HBA1C_T2          -1.866469e-02  1.934431e-03  9.089025e-03 -0.0147388426
## HBA1C.mmol.mol_T2 -4.687372e-02  9.282276e-03  1.385515e-02 -0.0395754867
## PESO_T2           -3.996100e-02  4.792402e-03 -5.610296e-02 -0.0046861161
## bmi_T2            -5.439833e-02 -8.760790e-02 -9.176157e-02  0.0125181754
## CC_T2             -3.330115e-03  3.180395e-03  7.853189e-03  0.0010885893
## CINT_T2           -3.267537e-02 -2.547401e-02 -3.721482e-03  0.0071539976
## CAD_T2            -4.376061e-02 -7.694771e-02 -3.730201e-02 -0.0014229483
## TAD_T2            -3.674138e-02  2.408975e-02  3.165393e-02  0.0021022451
## TAS_T2            -5.144915e-02  1.032674e-02  4.199758e-02  0.0282620518
## TG_T2             -5.238165e-02 -5.699211e-02  7.491251e-02 -0.0437275392
## COL_T2             3.732244e-03  4.966492e-03 -3.789377e-02 -0.0946462474
## LDL_T2             1.868101e-02  1.230630e-02 -8.715048e-02 -0.0976904420
## HDL_T2            -6.677259e-02  2.488449e-02  5.257104e-03 -0.0273675031
## VLDL_T2           -5.209887e-02 -1.132747e-01  1.754740e-01  0.0015005900
## PCR_T2            -1.830017e-02 -3.935942e-03  2.791217e-02 -0.0086044179
## LEP_T2             3.168884e-02 -6.125718e-02 -5.771016e-02  0.1438405149
## ADIPO_T2           1.571897e-02  8.014546e-02  4.411104e-02 -0.0062582151
## GOT_T2             2.228021e-02  4.052539e-02 -7.888622e-03  0.0882646606
## GPT_T2             8.101769e-03  3.634105e-02  2.623692e-02  0.0274718446
## GGT_T2            -4.851850e-02  5.059467e-02 -7.101961e-02 -0.1222737983
## URICO_T2           4.227973e-02 -5.331745e-02  8.082714e-02  0.0082861230
## CREAT_T2          -4.360571e-03  2.414756e-03 -2.007411e-03  0.0012131230
## UREA_T2            3.772326e-02  7.648248e-02  1.399225e-03  0.0026558020
## HIERRO_T2          6.913364e-02  6.104554e-02 -1.399134e-02 -0.0139462552
## TRANSF_T2          3.210866e-03  1.271075e-02  3.315105e-03 -0.0221571207
## FERR_T2            1.640012e-02  8.245482e-02  6.465144e-02  0.0230298027
## Ile_T2             5.052063e-02 -3.179452e-02  8.082869e-02 -0.0612761661
## Leu_T2             7.510430e-02 -7.317111e-03  1.184252e-01 -0.0390664414
## Val_T2             6.062708e-02  2.970554e-02  8.673447e-02 -0.0273913175
## Ala_T2            -4.965361e-02 -2.150844e-02 -8.922136e-02  0.0809352864
## Pro_T2            -3.229892e-02 -4.038788e-02 -3.638602e-02 -0.0241970817
## Gly_T2            -1.098524e-02 -1.134044e-01 -6.184091e-02  0.0755340322
## Ser_T2             1.802550e-02 -7.278438e-02 -3.313766e-02  0.0018552613
## Trp_T2            -3.226769e-02  6.286561e-02  2.801016e-02 -0.0349236430
## Phe_T2             3.813385e-02 -2.650647e-02  2.434629e-02 -0.0220316415
## Met_T2            -3.780731e-02  1.155330e-02 -6.735303e-02  0.1020735886
## Orn_T2            -8.681249e-03 -5.927436e-03  3.052949e-02 -0.0575022395
## Arg_T2            -1.016715e-02  5.989284e-03 -4.137115e-02 -0.0197440405
## His_T2             1.943650e-02  1.098003e-03  5.240918e-02 -0.0054791098
## Asn_T2            -5.908132e-02 -1.065075e-02  4.395179e-03  0.0033795614
## Asp_T2             9.302471e-02 -4.634613e-02  8.179066e-02  0.0508354728
## Glu_T2            -7.865619e-03 -2.968862e-02 -2.048585e-02 -0.0534555661
## Gln_T2            -7.726617e-02 -6.747845e-02 -3.214801e-02  0.0505391910
## Cit_T2            -5.613445e-02  7.249721e-03 -5.316835e-02  0.0022949046
## Tyr_T2            -6.655879e-04  3.641485e-02 -4.457884e-02  0.0194684259
## Thr_T2             6.619701e-03 -6.844192e-02 -6.759000e-02 -0.0412902764
## Lys_T2             2.555269e-02  1.658001e-02 -2.124907e-03 -0.0300684878
## Creatinine_T2     -1.900106e-03 -3.145752e-02 -9.801935e-02  0.0484549215
## Kynurenine_T2     -2.485123e-03  2.593708e-02 -2.030821e-02  0.0129233877
## Putrescine_T2      6.652030e-02 -6.024775e-02  2.980903e-02  0.0781277213
## Sarcosine_T2      -3.042963e-02 -6.332374e-02 -5.049497e-02 -0.0244823342
## Serotonin_T2      -7.673519e-02 -3.001253e-02 -1.614245e-02 -0.1243642193
## Taurine_T2         7.108312e-02  5.139463e-02  1.233043e-01  0.0763686610
## SDMA_T2            4.421092e-03 -6.543397e-03 -4.931097e-03  0.0126166768
## C0_T2             -6.316472e-02 -1.204439e-04 -8.497564e-02  0.0059315116
## C2_T2              1.189102e-01 -6.412399e-02 -7.030720e-02  0.1126108396
## C3.OH_T2          -2.290726e-03  6.545155e-04  2.744649e-03 -0.0022078970
## C6..C4.1.DC._T2    2.258994e-02 -7.766120e-02  1.090785e-02 -0.0254367965
## C5.DC..C6.OH._T2  -1.619005e-02  5.155818e-03 -1.095532e-01 -0.0155756251
## C7.DC_T2           2.990464e-02 -1.466274e-02  1.138201e-02 -0.0023680199
## C8_T2             -3.946277e-03 -2.016438e-03 -4.892815e-03 -0.0044819213
## C10_T2            -1.689649e-03 -2.955533e-03 -6.081421e-03 -0.0007395848
## C10.1_T2          -2.513332e-03 -2.849664e-03  1.533687e-03  0.0020764589
## C10.2_T2          -2.458157e-03  5.095748e-04  3.015318e-03 -0.0003455321
## C14.1_T2           9.581341e-04 -1.831067e-04  2.607623e-03  0.0011376951
## C14.2_T2          -6.780064e-04 -3.354923e-04  3.439437e-03 -0.0002416523
## C16.1_T2          -1.197514e-03 -2.329373e-04  3.646585e-03  0.0011283228
## C16.2_T2          -1.620023e-03 -2.986397e-04  4.920638e-03  0.0005425549
## C16.2.OH_T2       -1.925349e-03 -1.971836e-04  4.958466e-03  0.0007408784
## C18.1_T2           1.320525e-03 -2.112072e-03  3.154135e-03  0.0043350990
## C18.1.OH_T2       -1.464172e-03 -4.929566e-04  4.604429e-03  0.0007351050
## C18.2_T2          -1.373893e-03 -2.224329e-03  3.251917e-03  0.0007809380
## lysoPC.a.C14.0_T2 -3.677995e-02 -2.923850e-02  8.876420e-02  0.0581908527
## lysoPC.a.C16.0_T2 -1.208685e-02 -8.192508e-02  8.029034e-02 -0.0241047995
## lysoPC.a.C16.1_T2 -3.948579e-02 -1.446009e-02  8.883838e-03  0.0025430176
## lysoPC.a.C17.0_T2 -3.598833e-03  3.700620e-03  3.558876e-02 -0.0076883248
## lysoPC.a.C18.0_T2 -5.269251e-02 -2.915075e-02  6.362648e-02 -0.0239291566
## lysoPC.a.C18.1_T2 -2.505871e-02 -1.663872e-02  8.150667e-02 -0.0106986872
## lysoPC.a.C18.2_T2 -4.657792e-02 -2.341282e-02  9.445091e-02 -0.0658712176
## lysoPC.a.C20.3_T2 -3.207203e-02  2.221072e-02  3.415974e-02 -0.0229755470
## lysoPC.a.C20.4_T2  1.444971e-02 -1.112530e-01  9.779859e-02 -0.0213018757
## lysoPC.a.C24.0_T2 -2.777105e-03  8.500908e-05  5.345103e-03 -0.0080323068
## lysoPC.a.C26.0_T2 -9.179566e-03 -1.052720e-02  3.340391e-03 -0.1091144974
## lysoPC.a.C26.1_T2 -1.041887e-03 -3.110108e-03  5.151420e-03 -0.0075153838
## lysoPC.a.C28.0_T2 -2.385781e-02 -3.988558e-02  5.401882e-03 -0.0379939865
## lysoPC.a.C28.1_T2 -3.709839e-04 -1.106363e-03  8.998397e-03 -0.0085302107
## PC.aa.C24.0_T2    -1.298118e-01 -5.620048e-02 -8.064836e-02 -0.0829207712
## PC.aa.C28.1_T2     2.930604e-03  6.755254e-03 -9.384665e-04 -0.0124008972
## PC.aa.C30.0_T2     2.208935e-03  9.623885e-04 -1.712576e-02 -0.0126165401
## PC.aa.C32.0_T2     1.432949e-02 -4.641975e-02 -7.541881e-02  0.0057901909
## PC.aa.C32.1_T2    -8.722052e-02  9.063347e-03 -5.166026e-02  0.0119539189
## PC.aa.C32.3_T2    -6.695932e-04 -1.191564e-03  3.837161e-03  0.0023916435
## PC.aa.C34.1_T2    -7.697083e-03 -1.766733e-03 -5.023240e-02  0.0367099852
## PC.aa.C34.2_T2    -2.965096e-02  1.111724e-02 -3.471691e-02 -0.0108464339
## PC.aa.C34.3_T2    -8.067233e-02  4.185582e-02 -1.766267e-02 -0.0134416475
## PC.aa.C34.4_T2    -6.765616e-03  1.787664e-03  6.783151e-03 -0.0007239137
## PC.aa.C36.0_T2    -6.341451e-03 -5.793066e-03  2.698436e-02 -0.0150658643
## PC.aa.C36.1_T2    -3.845061e-02  4.876843e-02 -1.576159e-02 -0.0237283902
## PC.aa.C36.2_T2    -6.480395e-02  4.552595e-02 -4.789780e-02 -0.0137201942
## PC.aa.C36.3_T2    -6.441610e-02  8.761223e-02 -5.126831e-02 -0.0255967184
## PC.aa.C36.4_T2     5.568241e-02 -1.041115e-01 -3.371356e-03  0.0205163678
## PC.aa.C36.5_T2    -3.314449e-02 -3.607944e-03  1.515417e-01  0.0162920791
## PC.aa.C38.0_T2     8.104002e-04  2.896619e-03  1.602915e-02  0.0013676368
## PC.aa.C38.1_T2     5.861455e-02 -2.871147e-03 -3.771339e-02 -0.0221693999
## PC.aa.C38.3_T2    -3.806647e-02  6.544571e-02 -3.214165e-02 -0.0224144753
## PC.aa.C38.4_T2     1.558178e-03 -5.662668e-02 -6.919775e-03  0.0199731246
## PC.aa.C38.5_T2    -1.228018e-02 -1.200290e-02  1.706041e-02  0.0100805882
## PC.aa.C38.6_T2     2.917421e-03 -1.986587e-02  3.934234e-02  0.0816818640
## PC.aa.C40.1_T2    -6.924124e-02 -4.710837e-02 -7.295041e-03 -0.0143671371
## PC.aa.C40.2_T2    -4.678656e-03 -1.185868e-02  1.511581e-02 -0.0285623410
## PC.aa.C40.3_T2     1.189317e-03 -9.438854e-03  1.953338e-02 -0.0239311423
## PC.aa.C40.4_T2    -1.479429e-02 -8.520032e-03 -5.890299e-03 -0.0190113742
## PC.aa.C40.5_T2    -1.885592e-02  8.027006e-04  2.434047e-04  0.0021328353
## PC.aa.C40.6_T2    -3.058009e-02 -1.144868e-02  4.012578e-02  0.0608298334
## PC.aa.C42.0_T2     1.204363e-03 -2.812403e-03  6.591418e-03 -0.0034106153
## PC.aa.C42.1_T2    -8.630676e-04 -2.820587e-03  8.053977e-03 -0.0046885445
## PC.aa.C42.2_T2    -2.441937e-03 -6.136856e-03  1.532725e-02 -0.0088556520
## PC.aa.C42.4_T2    -5.244581e-03 -6.079982e-03  6.639555e-03 -0.0066574129
## PC.aa.C42.5_T2    -2.000450e-03 -2.636467e-03  9.132261e-03 -0.0037164715
## PC.aa.C42.6_T2    -2.984007e-02 -5.499950e-02 -4.436935e-02 -0.0534398559
## PC.ae.C30.0_T2     2.049246e-02 -2.869912e-02 -6.201548e-02 -0.0513567092
## PC.ae.C32.1_T2    -7.289163e-03  2.414964e-03 -3.817822e-03 -0.0092611737
## PC.ae.C32.2_T2     1.951732e-04  2.526118e-04  4.904568e-03  0.0004368340
## PC.ae.C34.0_T2    -2.687920e-04  2.624590e-03  6.139950e-03  0.0001831408
## PC.ae.C34.1_T2     1.971999e-03  3.323629e-02 -4.184153e-02  0.0136219169
## PC.ae.C34.2_T2    -5.188830e-03  4.079203e-02  7.715860e-04 -0.0161392083
## PC.ae.C34.3_T2    -9.197479e-03  2.884276e-02  1.884646e-02 -0.0177151862
## PC.ae.C36.0_T2     1.809620e-03 -2.074499e-04  6.262309e-03 -0.0059805546
## PC.ae.C36.1_T2    -1.689664e-03 -1.214117e-02  3.060512e-02 -0.0762661885
## PC.ae.C36.2_T2    -4.355065e-03  4.436821e-02  4.843645e-03 -0.0359354720
## PC.ae.C36.3_T2    -9.220431e-03  2.740392e-02 -3.608369e-03 -0.0036803256
## PC.ae.C36.4_T2    -1.033174e-02  1.068833e-03 -2.060577e-02 -0.0094113266
## PC.ae.C36.5_T2    -1.550596e-02 -9.174313e-03  2.554035e-02 -0.0050455480
## PC.ae.C38.0_T2    -1.471433e-02  1.123126e-03  1.836527e-02  0.0022830359
## PC.ae.C38.2_T2    -4.165890e-03 -9.514809e-03  2.407472e-02 -0.0597408459
## PC.ae.C38.3_T2    -9.173288e-03 -1.231086e-02  1.316578e-02 -0.0585365805
## PC.ae.C38.4_T2     3.414948e-03 -4.508882e-03 -1.125733e-02 -0.0078507268
## PC.ae.C38.5_T2     5.980881e-03 -9.338991e-03 -4.362373e-02  0.0179816901
## PC.ae.C38.6_T2    -9.233326e-03  4.946235e-03  2.626247e-03  0.0158618594
## PC.ae.C40.1_T2    -3.938301e-03 -1.171860e-02  2.784093e-02 -0.0273968282
## PC.ae.C40.2_T2     5.906797e-03 -1.431966e-03  1.157519e-02 -0.0151763794
## PC.ae.C40.3_T2    -8.555471e-03 -2.147302e-02  9.936931e-03 -0.0475325693
## PC.ae.C40.4_T2    -9.996471e-04 -1.631708e-02  9.088828e-03 -0.0306577721
## PC.ae.C40.5_T2    -6.578600e-03 -3.262640e-02 -1.387098e-02 -0.0102971379
## PC.ae.C40.6_T2     2.967512e-03  2.887625e-03  5.880075e-03  0.0113148288
## PC.ae.C42.1_T2    -2.775885e-03 -5.528474e-03  1.248924e-02 -0.0182332770
## PC.ae.C42.2_T2     1.180939e-03 -4.653578e-03  1.604582e-02 -0.0164618813
## PC.ae.C42.3_T2    -2.580995e-03 -8.777222e-03  1.598032e-02 -0.0167319200
## PC.ae.C42.4_T2    -2.236861e-03 -4.914132e-03  2.543882e-03 -0.0125497480
## PC.ae.C42.5_T2     2.604033e-03 -1.864488e-02 -1.719446e-02 -0.0029721488
## PC.ae.C44.3_T2     4.386574e-02 -1.097872e-02  3.348892e-02  0.0477667398
## PC.ae.C44.4_T2    -1.651125e-03  4.000952e-04  5.684539e-03 -0.0046074118
## PC.ae.C44.5_T2     1.207539e-02 -2.856619e-03 -1.189010e-02  0.0011050811
## PC.ae.C44.6_T2     4.470381e-03 -8.023470e-03  7.614233e-04 -0.0089197136
## SM..OH..C14.1_T2   3.407758e-02  1.827549e-02 -2.352631e-03  0.0049211529
## SM..OH..C16.1_T2   1.532831e-02  8.149757e-03 -5.247941e-03  0.0039515263
## SM..OH..C22.1_T2   8.762428e-03  2.387552e-02  6.283526e-03 -0.0273168232
## SM..OH..C22.2_T2   2.452668e-02  2.054029e-02 -3.807063e-03 -0.0154546613
## SM..OH..C24.1_T2   1.038283e-03  2.179560e-03  4.906484e-03 -0.0024402279
## SM.C16.0_T2        3.535308e-02 -1.372327e-02 -5.475868e-02 -0.0439789305
## SM.C16.1_T2        5.265534e-02 -3.926306e-02 -5.504333e-02  0.0218098268
## SM.C18.0_T2        4.089960e-02 -4.009198e-02 -8.600465e-02 -0.0128112110
## SM.C18.1_T2        3.536327e-02 -4.405124e-02 -6.496450e-02  0.0428750458
## SM.C20.2_T2       -1.331726e-03 -5.017183e-04  1.868595e-03  0.0006729776
## SM.C24.0_T2        2.164601e-04 -2.475467e-03  1.275686e-02 -0.0519350681
## SM.C24.1_T2        2.829636e-02 -2.668050e-03 -4.834760e-02  0.0027343204
## MEDDM_T4          -1.295473e-03 -5.331804e-03  5.530460e-03  0.0097149252
## MEDCOL_T4         -2.650089e-03 -5.983372e-04  3.549935e-03  0.0054578323
## MEDINF_T4          3.318262e-03 -1.372820e-03  2.427305e-03  0.0019825183
## MEDHTA_T4         -6.455330e-03  5.089846e-03  8.611329e-04  0.0108380690
## GLU_T4            -7.493697e-02  2.376852e-02  3.139682e-02 -0.0445207893
## INS_T4            -2.340086e-02  1.127757e-01  2.021811e-02  0.0578442030
## HOMA_T4           -2.509828e-02  4.256145e-02  1.368028e-02  0.0209313295
## HBA1C_T4          -2.010392e-02 -2.015043e-03  6.295856e-03 -0.0130612070
## HBA1C.mmol.mol_T4 -4.527543e-02 -5.261190e-03  2.236632e-03 -0.0284371325
## PESO_T4           -5.312961e-02  1.809541e-02 -5.026330e-02 -0.0063546167
## bmi_T4            -7.402317e-02 -7.316531e-02 -9.495582e-02  0.0136152531
## CC_T4             -7.056194e-04  5.256027e-03  9.987147e-03  0.0024911345
## CINT_T4           -2.697782e-02 -2.008694e-02  1.800854e-02  0.0026937986
## CAD_T4            -4.924032e-02 -7.074472e-02 -4.318821e-02 -0.0083538540
## TAD_T4            -4.321823e-02 -2.328115e-02 -6.655867e-03  0.0072105683
## TAS_T4            -2.975666e-02 -2.650662e-02  3.241129e-02  0.0122856330
## TG_T4             -1.174818e-01 -6.447793e-02  5.175604e-02  0.0115176366
## COL_T4             3.723046e-02  1.441646e-03 -2.590997e-02 -0.0426816828
## LDL_T4             5.956884e-02  1.164449e-02 -6.159743e-02 -0.0403188683
## HDL_T4            -3.760033e-02  2.357316e-03 -2.754176e-02 -0.0687380226
## VLDL_T4           -7.524685e-02 -1.205780e-01  1.377404e-01  0.0435821939
## PCR_T4            -6.069087e-02 -3.194738e-02 -3.272802e-02  0.0124664058
## LEP_T4            -1.018098e-02 -9.596398e-03 -8.770465e-02  0.1675452062
## ADIPO_T4           2.289002e-03 -5.989597e-03  2.140253e-02  0.0303903548
## GOT_T4            -4.115118e-02 -3.525690e-02 -4.441703e-02  0.0865174808
## GPT_T4            -8.637388e-02  2.736998e-02 -5.735997e-02  0.0716564597
## GGT_T4            -8.546196e-02  1.954159e-03 -2.662139e-02 -0.0027861727
## URICO_T4           1.068767e-02 -1.214144e-02 -5.310204e-03  0.0180252855
## CREAT_T4          -9.150039e-03  2.085617e-03 -1.853854e-03  0.0068742710
## UREA_T4            2.133015e-04  8.106883e-02 -3.805009e-02 -0.0104724145
## HIERRO_T4         -4.348133e-02 -3.944859e-02  8.162162e-02  0.1245721974
## TRANSF_T4         -3.453523e-02 -1.667368e-02 -7.195757e-03  0.0116768459
## FERR_T4           -7.816823e-03  9.822035e-02  4.360047e-02  0.0421972259
## Ile_T4             1.163504e-02  5.193232e-02  2.405492e-02 -0.0828697675
## Leu_T4             2.297811e-02  4.197335e-02  2.729327e-02 -0.0534384897
## Val_T4             9.445198e-03  6.522680e-02  2.092756e-02 -0.0380519760
## Ala_T4            -1.763418e-02  4.546700e-02 -2.391798e-02  0.0257009908
## Pro_T4            -2.278118e-02  2.859739e-02 -4.347456e-02 -0.0015923672
## Gly_T4             5.739095e-02  1.747084e-02 -3.888554e-02  0.0603150933
## Ser_T4             7.153170e-02 -5.511175e-02  7.909896e-02  0.0398153550
## Trp_T4            -2.676004e-02  8.555640e-02 -1.227187e-03 -0.0386540416
## Phe_T4            -2.049453e-02  8.016591e-03  2.689865e-02  0.0096587295
## Met_T4             4.800276e-02  4.112174e-02  5.443935e-02  0.0135018112
## Orn_T4             1.122618e-02  4.395973e-02 -7.633567e-03 -0.0011770820
## Arg_T4            -4.245186e-04  2.720594e-02  3.275895e-02 -0.0485316685
## His_T4             1.146091e-02  3.378728e-02  5.347014e-02  0.0032244036
## Asn_T4             4.670200e-03  5.058516e-02  2.127590e-02 -0.0173025573
## Asp_T4             2.658399e-02 -2.661118e-02  7.518619e-02 -0.0403337687
## Glu_T4            -6.579921e-02 -1.925407e-02 -2.812359e-02 -0.0231977186
## Gln_T4            -2.593357e-02 -9.741863e-02  8.213071e-02 -0.0168638094
## Cit_T4            -4.439789e-02  5.884181e-02 -7.484107e-02  0.0048290743
## Tyr_T4            -5.397288e-03  7.515435e-02 -4.532767e-02  0.0132189660
## Thr_T4             3.149534e-02  7.354850e-02  2.410017e-02 -0.0485327644
## Lys_T4            -2.347232e-02  1.263432e-02  1.645377e-02 -0.0697487960
## Creatinine_T4     -2.590991e-02  3.789686e-02 -7.452025e-02 -0.0064326814
## Kynurenine_T4     -7.620445e-02 -4.202042e-02  5.501209e-02  0.1265185922
## Putrescine_T4      4.423712e-02  1.334575e-01 -7.661190e-02 -0.0814278634
## Sarcosine_T4      -6.045354e-02 -2.451042e-02 -1.054396e-01 -0.0223365154
## Serotonin_T4      -8.411942e-02 -3.496282e-02 -2.381245e-02 -0.1033833319
## Taurine_T4         3.545426e-02 -4.708329e-02  2.572742e-02 -0.0312944405
## SDMA_T4            8.916119e-03  3.956933e-03 -2.056975e-03  0.0106525786
## C0_T4             -5.421013e-02  4.133338e-02 -5.315085e-02  0.0150384969
## C2_T4              1.113633e-01 -5.976079e-02  4.059245e-03 -0.0349456801
## C3.OH_T4          -9.781871e-04 -1.658117e-03  5.651928e-03  0.0024056703
## C6..C4.1.DC._T4    1.407094e-02  1.375677e-02  5.126134e-02 -0.1105328308
## C5.DC..C6.OH._T4  -3.389654e-02 -1.282606e-02  2.850482e-02  0.0848781270
## C7.DC_T4           2.193740e-02 -1.220653e-02  2.853109e-02 -0.0297964024
## C8_T4             -8.918929e-04 -3.387141e-03  4.262850e-03  0.0042676275
## C10_T4             1.240142e-03 -5.756215e-03  3.949145e-03  0.0083002701
## C10.1_T4          -1.166841e-03 -1.045918e-03  5.606479e-03  0.0037787876
## C10.2_T4          -1.830344e-03 -9.723453e-04  4.566798e-03  0.0013333581
## C14.1_T4           1.020480e-03 -1.907603e-03  4.578690e-03  0.0023696824
## C14.2_T4          -8.037149e-04 -7.107741e-04  5.414957e-03  0.0014237106
## C16.1_T4           3.751107e-02 -3.243110e-02  1.858516e-02 -0.0018264391
## C16.2_T4          -1.126651e-03 -7.809452e-04  5.077796e-03  0.0015449444
## C16.2.OH_T4        3.736621e-02 -3.208838e-02  1.918626e-02 -0.0020701484
## C18.1_T4           1.755487e-03 -3.035026e-04  3.763649e-03  0.0036094795
## C18.1.OH_T4       -1.576510e-03 -4.564687e-04  5.127279e-03  0.0013681041
## C18.2_T4          -9.847642e-04 -9.932597e-04  4.923804e-03  0.0019841141
## lysoPC.a.C16.0_T4  4.037983e-02  7.544760e-03 -3.310141e-02  0.0115412067
## lysoPC.a.C16.1_T4 -2.723577e-02  1.393745e-02 -5.499241e-02  0.0440453833
## lysoPC.a.C17.0_T4 -5.800321e-03  2.598344e-02 -1.117355e-02  0.0128179911
## lysoPC.a.C18.0_T4  1.112485e-02  2.918098e-02 -1.060694e-01  0.0176435860
## lysoPC.a.C18.1_T4  4.429074e-02  6.319496e-02 -8.939372e-02  0.0681703998
## lysoPC.a.C18.2_T4  1.578698e-02  9.278644e-02 -6.053442e-02 -0.0237613762
## lysoPC.a.C20.3_T4 -4.325612e-02  2.258825e-02 -1.070803e-02  0.0039024720
## lysoPC.a.C20.4_T4  9.082234e-02 -1.459664e-04 -6.507288e-02  0.0011632926
## lysoPC.a.C24.0_T4 -6.517620e-03 -1.212414e-03  3.279045e-04  0.0004975587
## lysoPC.a.C26.0_T4 -6.810683e-02 -5.640325e-02  1.065247e-02  0.0779078192
## lysoPC.a.C26.1_T4 -2.069844e-03 -3.928337e-03 -6.978009e-04  0.0035508310
## lysoPC.a.C28.0_T4 -7.398017e-02  1.194107e-03 -1.732627e-02 -0.0499178987
## lysoPC.a.C28.1_T4 -6.808825e-03 -5.394078e-04 -3.374665e-03  0.0018973755
## PC.aa.C24.0_T4    -7.051444e-02  2.596789e-02 -8.264745e-02  0.0638251598
## PC.aa.C28.1_T4    -1.082328e-03  6.940969e-03 -1.902713e-02 -0.0117843172
## PC.aa.C30.0_T4    -1.847169e-02 -1.317830e-03 -4.181354e-03 -0.0154490899
## PC.aa.C32.0_T4     1.668858e-02  1.666794e-02  2.792293e-03 -0.0032078459
## PC.aa.C32.1_T4    -1.399527e-01 -9.440877e-03 -2.535094e-02  0.0307321516
## PC.aa.C32.3_T4    -9.201313e-04 -1.182859e-03  4.904797e-03  0.0031834647
## PC.aa.C34.1_T4    -2.100532e-02  2.065384e-02  1.186823e-02  0.0358508612
## PC.aa.C34.2_T4    -4.637610e-02  2.027928e-02  9.766321e-02 -0.0411198330
## PC.aa.C34.3_T4    -1.257884e-01  3.302441e-02  7.458715e-03  0.0106919465
## PC.aa.C34.4_T4    -1.229109e-02  2.888821e-04  6.136133e-03  0.0022554930
## PC.aa.C36.0_T4    -1.524409e-02  2.413201e-03  3.147619e-03  0.0057142936
## PC.aa.C36.1_T4    -9.404976e-02  1.731575e-02 -7.178422e-02  0.0088955135
## PC.aa.C36.2_T4    -7.241037e-02  4.377590e-02 -4.812382e-02 -0.0145522606
## PC.aa.C36.3_T4    -1.239933e-01  2.884162e-02  4.338030e-02 -0.0050689253
## PC.aa.C36.4_T4     5.251400e-02 -3.912048e-02  4.341864e-02 -0.0300822379
## PC.aa.C36.5_T4    -4.321603e-02  6.057243e-02  4.913536e-02  0.0748988472
## PC.aa.C38.0_T4     6.521981e-03  1.275282e-02 -1.650410e-02  0.0186605785
## PC.aa.C38.1_T4    -1.748230e-02  1.304953e-03 -5.250107e-03 -0.0002006813
## PC.aa.C38.3_T4    -1.033076e-01  2.484938e-02 -2.837121e-02  0.0023824832
## PC.aa.C38.4_T4     4.534849e-02 -9.485006e-03 -6.920821e-02 -0.0129272609
## PC.aa.C38.5_T4     2.143364e-02  1.654691e-02 -3.914828e-02  0.0083500721
## PC.aa.C38.6_T4     1.702596e-03  3.532248e-02  7.096462e-02  0.0360990449
## PC.aa.C40.1_T4    -8.474161e-02 -1.229185e-02  2.478016e-03  0.0106947333
## PC.aa.C40.2_T4    -2.132563e-02 -1.145196e-02 -1.386711e-02 -0.0020841038
## PC.aa.C40.3_T4    -1.551076e-02 -8.432729e-03 -1.038642e-02 -0.0010668881
## PC.aa.C40.4_T4    -2.320279e-02 -2.394261e-02 -3.453169e-02 -0.0121040357
## PC.aa.C40.5_T4     2.307931e-03 -8.444595e-03 -4.986669e-02 -0.0167174637
## PC.aa.C40.6_T4    -2.475407e-02  4.127912e-02 -6.010511e-03  0.0487025383
## PC.aa.C42.0_T4    -3.870217e-03  4.360429e-03 -2.426919e-03 -0.0004417728
## PC.aa.C42.1_T4    -5.114811e-03 -1.085054e-04  3.747784e-04  0.0011432534
## PC.aa.C42.2_T4    -9.262751e-03 -2.642589e-03 -7.594724e-05  0.0022149311
## PC.aa.C42.4_T4    -1.052726e-02 -6.405428e-03 -8.049988e-04  0.0008754701
## PC.aa.C42.5_T4    -7.323015e-03 -2.400807e-03  2.884554e-03  0.0014305754
## PC.aa.C42.6_T4    -6.054114e-02 -4.924675e-02 -2.898328e-03  0.0683357786
## PC.ae.C30.0_T4    -2.203024e-02 -7.578749e-02 -1.912135e-02 -0.0185215624
## PC.ae.C32.1_T4     9.371062e-03  3.689998e-03 -1.189111e-02 -0.0045905359
## PC.ae.C32.2_T4     1.086619e-03  3.918959e-03  6.520971e-04  0.0055431117
## PC.ae.C34.0_T4    -2.640836e-03  2.582667e-03  2.715145e-03  0.0007981227
## PC.ae.C34.1_T4     4.116153e-03  2.238277e-02 -3.026539e-02  0.0113338502
## PC.ae.C34.2_T4     5.078699e-03  4.567501e-02 -1.321030e-03 -0.0303250354
## PC.ae.C34.3_T4     3.957786e-02  3.918072e-02  3.077758e-02 -0.0545512347
## PC.ae.C36.0_T4    -2.447907e-03  5.289520e-03 -2.311451e-03 -0.0011379638
## PC.ae.C36.1_T4    -5.829928e-02 -1.941394e-02 -2.693233e-02  0.0069053814
## PC.ae.C36.2_T4    -4.702053e-02  5.051322e-02  1.368048e-02 -0.0169190054
## PC.ae.C36.3_T4     1.334863e-04  1.531508e-02 -1.742777e-04 -0.0133291460
## PC.ae.C36.4_T4     4.367763e-02 -2.341534e-02 -2.525184e-02 -0.0183500304
## PC.ae.C36.5_T4     4.453169e-02  9.629096e-03 -7.336372e-03 -0.0141288387
## PC.ae.C38.0_T4    -1.777307e-02  1.548673e-02  1.038314e-02  0.0139101803
## PC.ae.C38.2_T4    -5.790050e-02 -1.554894e-02 -3.499079e-02  0.0017937244
## PC.ae.C38.3_T4    -6.477336e-02 -2.644613e-02 -4.097382e-02 -0.0073185533
## PC.ae.C38.4_T4     1.608328e-02 -1.126379e-02 -3.116375e-02 -0.0249284683
## PC.ae.C38.5_T4     6.674743e-02 -1.770418e-02 -6.574850e-02 -0.0043392121
## PC.ae.C38.6_T4     1.956796e-02  3.195460e-03 -6.375032e-03  0.0093377754
## PC.ae.C40.1_T4    -1.811397e-02 -2.586041e-03 -1.397305e-02  0.0012474342
## PC.ae.C40.2_T4    -1.500571e-02 -2.820296e-03 -1.666790e-02  0.0063025899
## PC.ae.C40.3_T4    -4.676762e-02 -2.052814e-02 -4.034991e-02 -0.0074752094
## PC.ae.C40.4_T4    -3.236552e-02 -1.495357e-02 -4.178233e-02 -0.0159697227
## PC.ae.C40.5_T4    -1.637092e-02 -3.271541e-02 -4.258599e-02  0.0049547833
## PC.ae.C40.6_T4     3.779801e-03  1.019306e-02 -3.216061e-03 -0.0019570226
## PC.ae.C42.1_T4    -1.599005e-02 -5.173152e-03 -6.604195e-03  0.0004231795
## PC.ae.C42.2_T4    -1.386100e-02  5.028259e-05 -7.429963e-03 -0.0013216977
## PC.ae.C42.3_T4    -1.589464e-02 -3.814850e-03 -5.022884e-03  0.0034947117
## PC.ae.C42.4_T4    -1.207602e-02 -1.894867e-03 -7.221414e-03 -0.0079837073
## PC.ae.C42.5_T4     6.300763e-03 -5.421748e-04 -3.765709e-02 -0.0010889071
## PC.ae.C44.3_T4    -6.826162e-03 -2.207277e-03  2.053766e-03  0.0024287768
## PC.ae.C44.4_T4    -5.741591e-03  1.191747e-03  1.924667e-03 -0.0021985656
## PC.ae.C44.5_T4     1.709520e-02  1.620136e-02 -1.897851e-02 -0.0137942015
## PC.ae.C44.6_T4     2.162904e-03  1.032298e-02 -7.603335e-03 -0.0166169021
## SM..OH..C14.1_T4   4.780053e-02  2.720107e-02 -2.271664e-04  0.0005496719
## SM..OH..C16.1_T4   2.352904e-02  1.407374e-02  4.451120e-03  0.0079479161
## SM..OH..C22.1_T4  -3.576727e-03  6.416017e-03  1.660380e-02 -0.0365897134
## SM..OH..C22.2_T4   2.778896e-02  1.927775e-02  5.258520e-03 -0.0102785912
## SM..OH..C24.1_T4  -5.972742e-04  2.067723e-03  6.147719e-03 -0.0035982009
## SM.C16.0_T4        9.719893e-02 -1.283219e-03 -2.714603e-02 -0.0380455309
## SM.C16.1_T4        1.117830e-01 -1.129718e-02 -1.636837e-02  0.0060722674
## SM.C18.0_T4        8.678898e-02 -4.460900e-03  1.913085e-02 -0.0158605584
## SM.C18.1_T4        1.050777e-01  9.065340e-04  7.384252e-03  0.0186197115
## SM.C20.2_T4       -2.077015e-05 -4.417493e-04  7.731068e-03  0.0014703816
## SM.C24.0_T4       -1.547723e-02 -1.798613e-02 -1.609691e-02 -0.0805591119
## SM.C24.1_T4        6.460294e-02  1.248107e-02  1.246190e-02 -0.0248924860
## MEDDM_T5          -2.081174e-02  1.056882e-02 -7.765598e-03 -0.0039299087
## MEDCOL_T5         -2.081174e-02  1.056882e-02 -7.765598e-03 -0.0039299087
## MEDINF_T5         -1.562626e-02  9.368336e-03 -1.014908e-02 -0.0058726748
## MEDHTA_T5         -2.029859e-02  5.276411e-03 -7.706921e-03  0.0043546784
## GLU_T5            -4.850176e-02  8.815011e-02 -3.588817e-02 -0.0608892550
## INS_T5            -2.914502e-02  6.020734e-02 -1.844044e-02  0.0632741786
## HOMA_T5           -2.224748e-02  2.130206e-02 -7.098189e-03  0.0292288118
## HBA1C_T5          -1.398728e-02  6.576271e-03  6.188167e-03 -0.0180955006
## HBA1C.mmol.mol_T5 -2.469779e-02  2.414254e-02  1.775917e-03 -0.0459650659
## PESO_T5           -1.549499e-02  8.774059e-02 -5.724180e-02 -0.0066225623
## bmi_T5            -2.948982e-02  3.666861e-02 -8.377885e-02 -0.0032648621
## CC_T5             -1.976964e-03  1.275530e-03  6.416352e-03  0.0013134145
## CINT_T5            2.636169e-02  6.735410e-02 -7.109619e-03 -0.0187550742
## CAD_T5            -1.879027e-03  3.834517e-02 -3.794307e-02 -0.0162866081
## TAD_T5            -4.854968e-02 -2.153560e-02 -1.952808e-02 -0.0542149538
## TAS_T5            -3.507771e-02 -6.366392e-03 -2.581057e-02 -0.0155192250
## TG_T5             -3.797592e-02  1.111037e-02  4.466578e-02  0.0348026225
## COL_T5             6.626638e-02  2.055128e-02 -2.699682e-02  0.0071322784
## LDL_T5             6.665046e-02 -8.472541e-03 -6.801093e-02  0.0428541658
## HDL_T5             1.488909e-02  6.985152e-02  2.085830e-02 -0.0910290601
## VLDL_T5           -2.392753e-02  7.682472e-03  3.734754e-02  0.0161033589
## PCR_T5            -5.071122e-02 -5.009994e-02 -3.546458e-02  0.0112419839
## LEP_T5            -4.134818e-02 -1.028549e-02 -3.014177e-02  0.1162121439
## ADIPO_T5           2.051206e-02  3.396495e-02  2.540838e-02 -0.0252458677
## GOT_T5            -3.068490e-02  1.275141e-02  5.060946e-02  0.1258844589
## GPT_T5            -4.343434e-02  1.247998e-01  1.539874e-02 -0.0002728195
## GGT_T5            -4.526442e-02  5.488615e-02 -5.448673e-02 -0.0398235266
## URICO_T5           8.480467e-03  2.192658e-02 -1.625237e-02  0.0171849560
## CREAT_T5          -3.509225e-03  3.737331e-03  2.195526e-03 -0.0009646659
## UREA_T5            3.323230e-02  1.235930e-01  3.873472e-02 -0.0486405975
## HIERRO_T5          9.666549e-02  9.877007e-03  2.441010e-02  0.0629378810
## TRANSF_T5          8.463357e-03  1.015686e-01  6.807358e-02  0.0110761344
## FERR_T5            6.369155e-03  5.604180e-02  7.838224e-03  0.0855653557
## Ile_T5            -3.336954e-02  4.904461e-02  1.376321e-03  0.0211100523
## Leu_T5            -1.226412e-02  6.550521e-02  2.355205e-03  0.0831055150
## Val_T5             8.561579e-03  5.148652e-02  3.524355e-04  0.0631247085
## Ala_T5            -4.279643e-02 -3.753889e-02 -1.515545e-02  0.0120853408
## Pro_T5            -1.548274e-02 -3.581537e-02 -6.748290e-02 -0.0470365194
## Gly_T5             5.110683e-02  5.064507e-03 -4.531085e-02  0.0800065704
## Ser_T5             9.573323e-02 -3.281263e-02  1.582205e-02  0.0332329245
## Trp_T5            -6.489964e-02  9.255702e-02 -1.766283e-03  0.0649768499
## Phe_T5            -6.020638e-02  2.843089e-02  7.487516e-03  0.1048608106
## Met_T5            -3.116552e-02  1.358938e-01  1.940083e-02  0.0116821619
## Orn_T5            -1.063276e-02  1.983470e-02  1.400235e-03  0.0742736238
## Arg_T5            -6.133284e-03  4.969942e-02 -2.487106e-02 -0.0142279137
## His_T5            -1.065237e-02  5.017631e-02  4.421831e-02  0.0380128807
## Asn_T5             4.016550e-02  3.968642e-02  2.486978e-02  0.0006018909
## Asp_T5             5.652827e-02 -4.405295e-02  6.944922e-02  0.1040657890
## Glu_T5            -7.596332e-02 -4.206812e-02 -6.550175e-02 -0.0072195118
## Gln_T5             4.561856e-02  4.329151e-02  8.141199e-03  0.0040326035
## Cit_T5            -3.769347e-02  8.063827e-03 -2.266801e-02 -0.0012472115
## Tyr_T5            -4.804466e-02  6.530464e-02 -4.718506e-02  0.0370228578
## Thr_T5             6.606665e-02  4.352222e-03  1.051103e-02 -0.0728558160
## Lys_T5            -6.104850e-03  6.392268e-02  2.823993e-03  0.0417210684
## Creatinine_T5     -6.518946e-02  2.181837e-02 -5.235192e-02  0.0198717582
## Kynurenine_T5      6.785544e-02  2.194862e-02  1.775936e-02  0.0499149696
## Putrescine_T5      2.719406e-02 -9.670620e-02 -1.667975e-02  0.1132713134
## Sarcosine_T5      -9.345545e-02 -6.952194e-02 -1.749498e-02  0.0734954566
## Serotonin_T5      -8.591257e-02 -4.374103e-02 -1.610258e-02 -0.1078159776
## Taurine_T5         1.077503e-01 -1.716561e-02 -8.698445e-02  0.0552367466
## SDMA_T5           -4.224464e-04 -3.736524e-03  1.276075e-03  0.0088220795
## C0_T5             -5.126281e-02 -4.727597e-03 -1.019627e-01  0.0227227533
## C2_T5              1.041443e-01 -1.868672e-02 -6.272151e-02  0.0470593600
## C3.OH_T5          -2.468334e-03  1.207828e-04  7.344300e-03  0.0017412401
## C6..C4.1.DC._T5   -3.011431e-04  2.924333e-02  4.014715e-02 -0.1492243831
## C5.DC..C6.OH._T5  -4.565800e-02 -2.436569e-02 -4.850992e-03 -0.0537736075
## C7.DC_T5           4.927564e-02 -2.413672e-02  1.949181e-02  0.0249028950
## C8_T5             -1.468589e-03 -5.079379e-03  3.260574e-03  0.0040353782
## C10_T5             1.209398e-04 -7.536917e-03  4.751249e-04  0.0061069470
## C10.1_T5           5.625801e-02  2.653400e-02  4.729538e-02  0.0460891279
## C10.2_T5          -1.405341e-03 -1.181242e-03  5.948637e-03  0.0017513635
## C14.1_T5          -4.788676e-04 -5.594180e-04  4.071114e-03  0.0033600112
## C14.2_T5          -1.842739e-03 -9.676381e-04  5.817099e-03  0.0027097426
## C16.1_T5          -2.063751e-03 -3.208800e-04  6.088143e-03  0.0023769162
## C16.2_T5          -1.884189e-03 -6.080136e-04  5.628540e-03  0.0018887851
## C16.2.OH_T5       -2.143942e-02 -2.639279e-02  4.992767e-02  0.0427751311
## C18.1_T5          -5.696302e-04 -6.520994e-04  3.513107e-03  0.0034940070
## C18.1.OH_T5       -1.977882e-03 -5.208588e-04  5.616562e-03  0.0017998338
## C18.2_T5          -1.811747e-03 -1.189840e-03  5.334482e-03  0.0019002457
## lysoPC.a.C16.0_T5  5.382241e-02 -4.164355e-02 -5.346017e-02 -0.0464451069
## lysoPC.a.C16.1_T5 -1.750179e-02  7.999928e-03 -2.727774e-02  0.0263609031
## lysoPC.a.C17.0_T5  1.705870e-02  8.507843e-03 -7.338015e-03  0.0024993974
## lysoPC.a.C18.0_T5  4.328994e-02 -4.144375e-02 -8.426773e-02 -0.0193554833
## lysoPC.a.C18.1_T5  8.918043e-02 -1.695322e-02 -8.285669e-02 -0.0502891957
## lysoPC.a.C18.2_T5  6.050813e-02  9.555206e-04 -4.958579e-02 -0.0900901983
## lysoPC.a.C20.3_T5 -1.558597e-02  1.822192e-03 -9.387871e-03 -0.0465404893
## lysoPC.a.C20.4_T5  7.430601e-02 -4.716172e-02 -4.170576e-02 -0.0896028541
## lysoPC.a.C24.0_T5 -2.045402e-03  4.862511e-04  8.528908e-03  0.0028554268
## lysoPC.a.C26.0_T5 -6.285003e-03 -2.453344e-03  8.517389e-03  0.0041849214
## lysoPC.a.C26.1_T5 -2.513678e-03 -7.387196e-04  9.935515e-03  0.0023878997
## lysoPC.a.C28.0_T5  3.794343e-02  5.972795e-02  3.942727e-02  0.0163230039
## lysoPC.a.C28.1_T5 -3.552208e-03 -1.714241e-03  8.940690e-03  0.0031638404
## PC.aa.C24.0_T5    -2.362515e-02 -4.718940e-04  8.798264e-03 -0.0275975449
## PC.aa.C28.1_T5    -1.014045e-02 -2.291068e-03  1.234597e-02  0.0036569985
## PC.aa.C30.0_T5    -4.025812e-02  1.146180e-02  2.671709e-02 -0.0109451415
## PC.aa.C32.0_T5    -1.305416e-02 -1.852370e-02 -5.022008e-02 -0.0380100985
## PC.aa.C32.1_T5    -1.564272e-01  1.756958e-02  3.156633e-02  0.0561304941
## PC.aa.C32.3_T5    -2.867420e-03 -1.426002e-03  5.411692e-03  0.0016981573
## PC.aa.C34.1_T5    -4.306572e-03 -2.731269e-02 -9.376047e-03  0.0071543826
## PC.aa.C34.2_T5    -3.688509e-02 -3.251400e-03  3.644399e-02 -0.0430441207
## PC.aa.C34.3_T5    -1.398913e-01  5.135844e-02  5.871286e-02  0.0058776565
## PC.aa.C34.4_T5    -1.475974e-02  4.617115e-03  1.204351e-02 -0.0009490277
## PC.aa.C36.0_T5    -1.498868e-02 -2.460533e-03  9.165472e-03  0.0021215915
## PC.aa.C36.1_T5    -3.495045e-02 -2.491547e-02 -4.181222e-02  0.0168199076
## PC.aa.C36.2_T5    -4.326090e-02  5.196599e-03 -1.022633e-02  0.0040416153
## PC.aa.C36.3_T5    -7.517671e-02  4.505375e-02  2.919006e-02 -0.0349186683
## PC.aa.C36.4_T5     1.019703e-02 -4.219500e-02  3.366874e-02 -0.0586223784
## PC.aa.C36.5_T5    -6.315968e-02  8.785641e-02  6.420561e-02  0.0193465031
## PC.aa.C38.0_T5     2.780755e-02  1.517900e-02 -2.002826e-02  0.0181399640
## PC.aa.C38.1_T5    -1.797375e-03 -4.507246e-03 -5.578676e-03 -0.0121219299
## PC.aa.C38.3_T5    -1.149923e-01  6.823213e-03  8.612151e-03  0.0129592670
## PC.aa.C38.4_T5     1.347900e-02 -3.448057e-02 -1.325481e-02 -0.0251950256
## PC.aa.C38.5_T5     4.063183e-02  9.058113e-03 -1.450735e-03 -0.0569493819
## PC.aa.C38.6_T5     1.305196e-02  3.971434e-02  3.326100e-02  0.0037503416
## PC.aa.C40.1_T5     3.289395e-02 -8.623366e-03 -1.000701e-02 -0.0124305464
## PC.aa.C40.2_T5    -1.118613e-02 -1.069594e-02 -6.004076e-05  0.0035016565
## PC.aa.C40.3_T5    -1.013637e-02 -1.099005e-02  2.626527e-03  0.0046237440
## PC.aa.C40.4_T5    -9.866928e-03 -1.940447e-02 -4.954589e-04 -0.0082103897
## PC.aa.C40.5_T5     1.911970e-03 -1.478236e-02 -1.829028e-02 -0.0362889705
## PC.aa.C40.6_T5    -1.849756e-02  4.335719e-02  8.295702e-03  0.0474317438
## PC.aa.C42.0_T5    -1.240998e-03  2.019969e-03  2.462554e-03  0.0021215176
## PC.aa.C42.1_T5    -1.806202e-03  6.061763e-04  3.402504e-03  0.0049084707
## PC.aa.C42.2_T5    -4.228066e-03 -3.552449e-03  4.633014e-03  0.0046101971
## PC.aa.C42.4_T5    -6.308198e-03 -6.863599e-03  3.560124e-03  0.0022740676
## PC.aa.C42.5_T5    -5.366168e-03 -2.930076e-03  6.013056e-03  0.0005530058
## PC.aa.C42.6_T5     4.071468e-02  3.551084e-02  7.770383e-02  0.0598464133
## PC.ae.C30.0_T5     4.291719e-02 -7.121238e-03  3.301150e-02  0.0543764595
## PC.ae.C32.1_T5     2.683900e-03 -2.988532e-03 -1.127892e-02 -0.0148835464
## PC.ae.C32.2_T5    -7.593506e-04 -7.632967e-04  4.510395e-05  0.0024565860
## PC.ae.C34.0_T5    -6.905260e-03  3.500301e-03  3.832511e-03  0.0031883212
## PC.ae.C34.1_T5    -8.218752e-04  5.505601e-03 -2.956941e-02  0.0112164182
## PC.ae.C34.2_T5     1.065364e-02  4.128241e-02 -3.252644e-02 -0.0481666502
## PC.ae.C34.3_T5     4.301486e-02  1.424191e-02 -1.555203e-02 -0.0811720803
## PC.ae.C36.0_T5    -6.463950e-04 -6.041231e-04 -4.904825e-03  0.0014831578
## PC.ae.C36.1_T5    -3.941162e-02 -2.702503e-02 -9.584730e-03  0.0214162134
## PC.ae.C36.2_T5    -2.949747e-02  2.446285e-02  1.740811e-02  0.0263046444
## PC.ae.C36.3_T5     9.495029e-03  1.092583e-02 -1.238406e-02 -0.0315957989
## PC.ae.C36.4_T5     1.455233e-02 -3.693983e-02 -7.105231e-02 -0.0452336949
## PC.ae.C36.5_T5     4.708954e-02 -3.352299e-02 -2.424009e-02 -0.0848383266
## PC.ae.C38.0_T5    -1.200264e-02  1.560144e-02  1.267460e-02  0.0077399859
## PC.ae.C38.2_T5    -2.622793e-02 -2.508219e-02 -7.236827e-03  0.0225878633
## PC.ae.C38.3_T5    -5.640747e-02 -2.004228e-02 -3.016690e-02 -0.0058085900
## PC.ae.C38.4_T5     8.018037e-03 -3.132280e-02 -1.202821e-02 -0.0248438082
## PC.ae.C38.5_T5     6.984241e-02 -6.275260e-02 -8.631091e-02 -0.0576176363
## PC.ae.C38.6_T5     2.406211e-02 -2.515467e-03 -1.670834e-02 -0.0181967745
## PC.ae.C40.1_T5    -4.490480e-03 -7.113942e-03  2.382028e-03 -0.0028566607
## PC.ae.C40.2_T5    -1.410563e-02 -5.020531e-03 -6.118382e-03  0.0103271885
## PC.ae.C40.3_T5    -4.128023e-02 -2.191925e-02 -3.215633e-02 -0.0029269174
## PC.ae.C40.4_T5    -2.057014e-02 -2.521142e-02 -2.237836e-02 -0.0063500844
## PC.ae.C40.5_T5    -1.445916e-02 -4.230486e-02 -3.935509e-02 -0.0219391199
## PC.ae.C40.6_T5     1.045541e-02  5.053656e-03  1.777008e-05 -0.0085295768
## PC.ae.C42.1_T5    -7.886287e-03 -5.319467e-03  2.233230e-03  0.0020880933
## PC.ae.C42.2_T5    -5.663892e-03  5.160064e-04  1.562981e-03  0.0033011567
## PC.ae.C42.3_T5    -4.678175e-03 -5.246893e-03  1.283646e-04  0.0068582778
## PC.ae.C42.4_T5    -7.433297e-03 -4.612452e-03  1.953919e-03  0.0002139039
## PC.ae.C42.5_T5    -5.808928e-03 -1.698748e-02 -3.294375e-02 -0.0059125315
## PC.ae.C44.3_T5    -4.963524e-03 -3.838780e-03  4.558069e-03  0.0037987458
## PC.ae.C44.4_T5    -4.656586e-03  2.410085e-03  5.014143e-03  0.0012256193
## PC.ae.C44.5_T5     1.797740e-02  1.157092e-02 -8.220314e-03  0.0049614066
## PC.ae.C44.6_T5     7.048495e-03  8.400843e-03  8.375004e-04 -0.0009822000
## SM..OH..C14.1_T5   2.897710e-02  1.112334e-02 -3.324202e-04  0.0157039796
## SM..OH..C16.1_T5   4.470688e-03  4.904259e-03  5.222737e-03  0.0053724613
## SM..OH..C22.1_T5  -2.398802e-02 -1.090786e-03  4.819043e-02 -0.0001437126
## SM..OH..C22.2_T5  -3.152649e-03  6.724051e-03  3.099522e-02  0.0354596196
## SM..OH..C24.1_T5  -2.512636e-03  8.914316e-04  9.459098e-03  0.0007749265
## SM.C16.0_T5        4.042694e-02 -3.327086e-02 -2.713603e-02 -0.0529319062
## SM.C16.1_T5        6.674743e-02 -1.007469e-01 -5.995091e-02  0.0134431083
## SM.C18.0_T5        3.709264e-03 -5.553475e-02 -1.426900e-02 -0.0303357430
## SM.C18.1_T5        5.455986e-02 -8.278639e-02 -3.939433e-02  0.0416899192
## SM.C20.2_T5       -3.669526e-03 -1.460582e-04  8.291470e-03  0.0010177266
## SM.C24.0_T5       -4.985417e-02 -1.554525e-02  7.993107e-02 -0.0226156245
## SM.C24.1_T5        2.046299e-02 -2.194082e-02  2.002126e-02 -0.0404614627
##                            PC13          PC14          PC15          PC16
## GLU_T0             5.141493e-02 -7.219548e-02 -5.962212e-02 -2.705124e-02
## INS_T0            -5.384979e-02  1.128731e-02  3.458168e-02  4.471072e-02
## HOMA_T0           -3.760427e-02 -1.613231e-02  1.811031e-02  1.248858e-02
## HBA1C_T0           3.474008e-02 -2.580934e-02 -3.194377e-02 -7.560693e-03
## HBA1C.mmol.mol_T0  8.374654e-02 -5.809960e-02 -4.806977e-02 -2.526540e-02
## PESO_T0           -1.950702e-02 -8.854584e-03  4.051256e-02  6.041467e-02
## bmi_T0            -3.245784e-04 -2.833772e-02  6.593482e-02  3.441530e-02
## CC_T0             -3.910616e-03  1.304292e-03 -6.995302e-03  3.414125e-03
## CINT_T0           -1.712961e-02 -2.747807e-02  4.440789e-02  3.862337e-02
## CAD_T0             7.429343e-02 -4.922629e-02  6.012169e-02  3.671128e-02
## TAD_T0             1.019066e-01  2.601276e-03 -5.922777e-04 -1.511037e-02
## TAS_T0             1.366959e-02  1.708692e-02  1.672540e-02 -1.675028e-02
## TG_T0              2.058515e-02  4.920415e-02 -6.785753e-02 -5.173345e-02
## COL_T0            -4.732177e-03  6.335156e-02 -1.557457e-02  1.380372e-02
## LDL_T0            -4.103886e-02  8.649787e-02 -9.259378e-03  3.747076e-02
## HDL_T0             8.695766e-02 -4.221359e-02  2.079271e-02  9.428390e-03
## VLDL_T0            2.063367e-02  4.976862e-02 -6.934742e-02 -5.238978e-02
## PCR_T0             8.490935e-02  4.475327e-02 -1.689150e-01  7.079026e-02
## LEP_T0            -2.383195e-02 -7.471570e-03  1.915333e-02  2.717318e-02
## ADIPO_T0           9.950859e-03  4.122024e-02  2.048858e-02  2.142389e-02
## GOT_T0             2.720371e-02 -1.134246e-01  8.506484e-02 -2.945194e-02
## GPT_T0             7.478975e-02 -2.455289e-02  5.919745e-02 -7.179674e-02
## GGT_T0            -4.027772e-02 -9.503562e-02 -3.859045e-02 -5.213714e-02
## URICO_T0          -3.424369e-02 -1.167318e-02 -1.642718e-02 -9.566314e-03
## CREAT_T0           1.756781e-03  6.099136e-03 -1.250414e-02  1.116741e-03
## UREA_T0            1.484683e-02  3.438809e-02 -1.489944e-01  2.835839e-02
## HIERRO_T0          2.570517e-02  1.355956e-01  1.262175e-01 -2.559464e-02
## TRANSF_T0          8.270035e-02 -3.057057e-02 -9.537038e-03  2.557368e-03
## FERR_T0           -1.645238e-01  9.168878e-02  4.144697e-02 -1.285887e-01
## Ile_T0             2.977558e-03 -3.461059e-02 -3.184301e-02  2.321505e-02
## Leu_T0             1.405504e-02 -3.608303e-02 -4.971406e-02 -3.799123e-03
## Val_T0            -1.350105e-03 -5.719301e-02 -4.167736e-02 -5.918682e-02
## Ala_T0             1.385045e-02 -5.650804e-02 -7.000370e-03 -4.254846e-02
## Pro_T0            -5.068030e-02  5.302423e-03  1.367785e-02  2.876428e-02
## Gly_T0            -3.631442e-02  3.623082e-03 -5.686230e-02  4.272030e-02
## Ser_T0             3.657978e-02  3.271255e-02  8.147758e-02  3.907260e-02
## Trp_T0             4.985822e-02  1.336987e-02 -3.466175e-02 -8.932330e-02
## Phe_T0             6.113769e-02 -7.751617e-02 -3.761134e-02  6.109606e-02
## Met_T0             1.393038e-02 -2.870804e-02 -2.953293e-02 -5.203493e-02
## Orn_T0            -1.492541e-02 -3.306024e-03 -3.535536e-02 -1.458473e-02
## Arg_T0             1.089058e-01  7.726472e-03  1.703543e-02 -1.406654e-02
## His_T0             4.922757e-02  2.834948e-02  9.399472e-03 -2.588782e-02
## Asn_T0             2.389645e-03  7.580417e-02 -7.769315e-02  7.057634e-02
## Asp_T0             2.502621e-02 -1.010975e-02 -6.375996e-03 -1.646077e-03
## Glu_T0             3.843436e-02 -7.249976e-03 -1.235150e-02 -3.494354e-02
## Gln_T0            -3.142882e-02  2.800834e-02 -2.493432e-04  2.869976e-02
## Cit_T0             2.629486e-02  9.355353e-02 -7.187075e-02  5.349005e-02
## Tyr_T0             1.831215e-02 -8.003535e-02  3.770730e-03  2.836779e-02
## Thr_T0             6.703424e-02  9.738595e-02 -1.592595e-02  7.126582e-02
## Lys_T0             2.296256e-02  9.594787e-03  4.366680e-02 -2.067158e-02
## Creatinine_T0      3.046334e-02  1.171250e-01 -1.254451e-01  1.017965e-01
## Kynurenine_T0      3.260037e-02 -5.683234e-03 -2.720072e-02  2.994437e-03
## Putrescine_T0      8.177455e-02  7.379027e-02  5.072922e-04 -4.402862e-02
## Sarcosine_T0       3.295754e-03  1.146212e-01 -1.005133e-02  8.919530e-02
## Serotonin_T0       1.032980e-02 -1.047646e-02  3.837678e-02 -9.569734e-05
## Taurine_T0        -1.396424e-02  3.356557e-02 -3.524098e-02  2.554831e-02
## SDMA_T0            7.131088e-03  8.455406e-03 -1.045002e-02  4.227258e-03
## C0_T0              7.460148e-03 -2.917975e-02  4.032854e-02 -1.521683e-03
## C2_T0             -1.838454e-02  6.664284e-03 -1.491165e-02 -2.560137e-02
## C3.OH_T0           2.196000e-03  6.413780e-04 -4.093030e-03 -2.088462e-03
## C6..C4.1.DC._T0    1.091920e-01  1.623566e-01  3.224757e-03  3.403693e-02
## C5.DC..C6.OH._T0   8.192831e-02 -5.073287e-02 -2.874541e-02  6.358915e-03
## C7.DC_T0           5.509703e-02  3.485395e-02  2.575489e-03 -8.048818e-02
## C8_T0              8.291835e-03 -6.725543e-05 -4.635540e-03 -2.860514e-04
## C10_T0             4.702815e-03 -1.958622e-03 -2.691206e-03 -2.269376e-03
## C10.1_T0           3.462443e-04  2.190417e-04 -4.868716e-03 -2.038216e-03
## C10.2_T0           2.362772e-03  1.769956e-03 -4.483577e-03 -1.283480e-03
## C14.1_T0           8.708582e-04  1.407440e-03 -4.093697e-03 -4.056312e-04
## C14.2_T0           1.115296e-03  1.711299e-03 -4.297274e-03 -9.486105e-04
## C16.1_T0           1.055483e-03  2.362971e-03 -4.741371e-03 -2.263651e-04
## C16.2_T0           2.496446e-04  1.086648e-03 -5.070221e-03 -1.531425e-03
## C16.2.OH_T0        3.901981e-04  1.565536e-03 -4.927108e-03 -1.519926e-03
## C18.1_T0           2.763410e-04  2.179048e-03 -5.165564e-03 -1.377643e-03
## C18.1.OH_T0        1.248136e-04  1.452536e-03 -5.236728e-03 -1.626770e-03
## C18.2_T0          -5.130158e-04  1.787879e-03 -5.097074e-03 -1.708657e-03
## lysoPC.a.C16.0_T0 -3.785797e-02  4.808480e-02  1.634566e-02 -5.667091e-03
## lysoPC.a.C16.1_T0 -2.034498e-02  6.877860e-03 -1.269925e-04 -9.489678e-04
## lysoPC.a.C17.0_T0 -5.325760e-03  2.234076e-02 -1.298986e-03  2.507557e-03
## lysoPC.a.C18.0_T0 -6.339316e-02  1.746026e-02  4.345781e-02  6.637351e-03
## lysoPC.a.C18.1_T0 -4.051902e-02  3.322446e-02  2.689819e-02  1.155800e-02
## lysoPC.a.C18.2_T0 -5.716420e-02  5.851120e-02  6.031152e-02  7.842613e-05
## lysoPC.a.C20.3_T0 -7.093241e-03 -2.216467e-02  3.182628e-03 -3.258144e-02
## lysoPC.a.C20.4_T0 -3.021985e-02  1.223304e-01 -2.973055e-02 -3.844636e-02
## lysoPC.a.C24.0_T0 -1.678607e-03  3.136869e-03  2.892817e-03 -2.784118e-03
## lysoPC.a.C26.0_T0  5.699692e-02  1.132216e-03 -1.561724e-04  3.122316e-02
## lysoPC.a.C26.1_T0  2.423102e-03  4.248632e-03  8.650749e-04 -3.366425e-04
## lysoPC.a.C28.0_T0  4.740925e-02 -3.950280e-02  8.292573e-02 -3.544344e-02
## lysoPC.a.C28.1_T0  2.883367e-03  3.105138e-03  1.313087e-03  5.328662e-04
## PC.aa.C24.0_T0     3.464479e-02 -6.356230e-02  6.579008e-02 -4.524986e-02
## PC.aa.C28.1_T0     2.479188e-02 -2.432316e-04  1.093844e-02 -9.499456e-03
## PC.aa.C30.0_T0     1.249357e-02 -1.791912e-02 -1.231911e-02 -9.342000e-03
## PC.aa.C32.0_T0    -4.888838e-03 -1.320407e-02 -6.853638e-03 -1.165747e-03
## PC.aa.C32.1_T0    -1.200132e-04 -1.269324e-01 -2.210905e-02 -6.049645e-02
## PC.aa.C32.3_T0    -4.713011e-04  1.958680e-04 -4.580818e-03 -7.200718e-04
## PC.aa.C34.1_T0     3.660730e-03 -1.073689e-01  1.267320e-03 -5.185610e-02
## PC.aa.C34.2_T0     6.598531e-03 -4.612110e-02  6.178844e-02 -1.040059e-02
## PC.aa.C34.3_T0    -9.492147e-03 -6.104216e-02  1.400844e-02 -5.505875e-02
## PC.aa.C34.4_T0     9.884340e-04  1.386741e-03 -1.391656e-02 -1.577393e-02
## PC.aa.C36.0_T0    -1.893221e-03 -6.569817e-03  7.988761e-03  1.116967e-02
## PC.aa.C36.1_T0    -1.836230e-02 -1.202581e-01  1.483459e-02  8.071728e-03
## PC.aa.C36.2_T0    -2.103913e-02 -8.933309e-02  8.983268e-02 -1.817039e-02
## PC.aa.C36.3_T0     2.522455e-02 -6.618847e-02  2.737256e-02 -4.184537e-02
## PC.aa.C36.4_T0    -1.849946e-02  1.143852e-01 -6.645978e-02 -6.613121e-02
## PC.aa.C36.5_T0     4.037981e-02 -4.228888e-02 -6.405307e-02  1.197798e-02
## PC.aa.C38.0_T0    -8.975539e-03 -3.282948e-02  1.193377e-03  2.558358e-02
## PC.aa.C38.1_T0     3.867578e-02  6.783972e-02  5.575626e-03  2.013685e-02
## PC.aa.C38.3_T0    -1.917174e-02 -1.277987e-01  1.219045e-02 -5.094172e-02
## PC.aa.C38.4_T0    -5.618505e-02  5.595347e-02 -8.085370e-02 -6.585803e-02
## PC.aa.C38.5_T0    -2.170904e-02  1.608613e-03 -9.419634e-02 -3.487353e-02
## PC.aa.C38.6_T0     1.394747e-02  3.551615e-02 -1.300633e-02 -3.463032e-02
## PC.aa.C40.1_T0     3.479592e-02 -2.432720e-02 -6.761821e-03 -4.286994e-02
## PC.aa.C40.2_T0     3.989885e-03  7.576605e-03  5.120283e-03  1.093685e-02
## PC.aa.C40.3_T0     3.177388e-04  4.922704e-03  5.720531e-03  9.938541e-03
## PC.aa.C40.4_T0    -1.186984e-02  4.786807e-03 -3.218408e-03 -1.141253e-02
## PC.aa.C40.5_T0    -2.024552e-02 -2.258866e-03 -2.040589e-02 -3.999110e-02
## PC.aa.C40.6_T0    -3.176927e-02 -5.054418e-02 -4.215727e-02 -1.228442e-02
## PC.aa.C42.0_T0     8.810937e-04  3.564343e-03 -5.980087e-03  8.268680e-03
## PC.aa.C42.1_T0     2.933362e-04  2.948889e-03 -3.465918e-03  3.664683e-03
## PC.aa.C42.2_T0    -1.557129e-04  2.241100e-03  1.374323e-03  5.607611e-03
## PC.aa.C42.4_T0    -4.239552e-04  6.360258e-03  1.263988e-04  5.065807e-03
## PC.aa.C42.5_T0    -1.830270e-03  2.568251e-03 -2.362554e-03  2.285540e-03
## PC.aa.C42.6_T0     4.782772e-02  5.200264e-03 -6.553857e-02  2.245861e-02
## PC.ae.C30.0_T0     1.696284e-03 -3.931237e-04 -4.151497e-03 -1.520336e-04
## PC.ae.C32.1_T0     3.134637e-03 -1.795266e-02  2.432973e-03  3.050484e-03
## PC.ae.C32.2_T0     2.634999e-03 -5.772320e-03 -8.040432e-04  8.742123e-04
## PC.ae.C34.0_T0     2.598012e-03 -2.079743e-03 -3.583714e-03 -1.077498e-03
## PC.ae.C34.1_T0     2.642443e-02 -3.379091e-02  1.447874e-02  1.149519e-02
## PC.ae.C34.2_T0    -9.762540e-03 -5.300837e-02  4.123903e-02 -2.894434e-02
## PC.ae.C34.3_T0    -9.063899e-03 -7.928826e-02  3.921920e-02 -8.313935e-03
## PC.ae.C36.0_T0    -2.885341e-04 -2.701254e-03  3.509939e-04  6.585892e-03
## PC.ae.C36.1_T0     1.478402e-02  9.333740e-03  1.730939e-02  1.594435e-02
## PC.ae.C36.2_T0     1.943157e-02  4.412193e-04  3.170225e-02  1.551789e-02
## PC.ae.C36.3_T0    -4.903614e-03 -5.947667e-02  2.760065e-02 -2.298529e-03
## PC.ae.C36.4_T0    -3.496347e-02  1.883937e-03  8.249445e-03 -1.571874e-02
## PC.ae.C36.5_T0    -4.118014e-02 -4.227569e-03 -2.330245e-02 -2.584864e-02
## PC.ae.C38.0_T0    -2.625893e-03 -1.083361e-02 -8.322198e-03 -6.398684e-03
## PC.ae.C38.2_T0     2.674084e-03  1.390881e-02  2.233899e-02  2.969783e-02
## PC.ae.C38.3_T0     3.265775e-02 -7.647747e-03 -1.170029e-03 -1.692200e-02
## PC.ae.C38.4_T0     5.276245e-03  4.549940e-02 -2.076707e-02 -6.490052e-03
## PC.ae.C38.5_T0    -2.622850e-02  8.434287e-03 -8.540692e-03  2.348713e-02
## PC.ae.C38.6_T0    -1.643416e-02 -2.462850e-02 -1.356813e-02  8.392318e-03
## PC.ae.C40.1_T0    -1.740521e-03  6.089795e-03  1.989327e-03  8.460741e-07
## PC.ae.C40.2_T0     1.059935e-02  9.476409e-03  2.397696e-03  1.223490e-02
## PC.ae.C40.3_T0     2.129185e-02 -3.818543e-03  2.147321e-03 -6.602165e-03
## PC.ae.C40.4_T0     1.414097e-02  7.741999e-03  1.958565e-03  2.444524e-03
## PC.ae.C40.5_T0     1.352562e-02  1.351781e-02 -7.399324e-04  1.196612e-02
## PC.ae.C40.6_T0     6.379463e-03  1.122148e-02 -9.504315e-03  5.840895e-03
## PC.ae.C42.1_T0     2.082964e-03  6.084880e-03  4.218070e-03  4.440637e-03
## PC.ae.C42.2_T0     1.181774e-03  1.747407e-03  1.905149e-03  9.159710e-03
## PC.ae.C42.3_T0     6.216542e-04  3.381969e-03  6.001378e-03  1.284790e-02
## PC.ae.C42.4_T0     1.316112e-03  2.634260e-03  1.254553e-03  9.075825e-03
## PC.ae.C42.5_T0     6.101065e-03  1.214696e-02 -1.039876e-02  1.533583e-02
## PC.ae.C44.3_T0     7.964914e-04  2.566270e-03 -5.017488e-04  2.924902e-03
## PC.ae.C44.4_T0    -8.061217e-04 -3.074091e-03 -3.626500e-03  3.578851e-03
## PC.ae.C44.5_T0    -1.126738e-03  8.682700e-03 -2.377922e-02  1.782739e-02
## PC.ae.C44.6_T0    -2.893364e-03  1.105769e-02 -1.022339e-02  8.450013e-03
## SM..OH..C14.1_T0   1.471195e-02  3.597448e-03  1.504151e-02  3.490243e-04
## SM..OH..C16.1_T0   1.323938e-02  1.136795e-02  5.238075e-03  6.220306e-03
## SM..OH..C22.1_T0   1.020686e-02  2.720062e-02  2.769171e-02 -1.701451e-03
## SM..OH..C22.2_T0   2.777604e-02  3.944366e-03  3.986884e-02  1.529814e-02
## SM..OH..C24.1_T0   4.035855e-03  4.010034e-03 -3.159141e-03  1.103572e-03
## SM.C16.0_T0        8.966225e-03  5.011620e-02  8.111722e-02  7.177895e-02
## SM.C16.1_T0       -4.168141e-03 -1.814328e-02  7.120288e-02  2.479448e-02
## SM.C18.0_T0        3.881198e-02  4.017650e-02  4.598871e-02  7.248017e-02
## SM.C18.1_T0        2.492715e-02  2.137486e-02  5.242820e-02  4.495264e-02
## SM.C20.2_T0        9.551794e-04  3.736142e-03 -4.984414e-03 -9.834921e-04
## SM.C24.0_T0       -3.210074e-02  2.142028e-02  3.378150e-02  3.508423e-02
## SM.C24.1_T0        7.657633e-03  3.024682e-02  4.692087e-03  7.839615e-02
## MEDDM_T2          -6.326798e-04  1.059160e-03 -5.539757e-03 -1.473953e-03
## MEDCOL_T2         -6.326798e-04  1.059160e-03 -5.539757e-03 -1.473953e-03
## MEDINF_T2         -9.121179e-04 -9.586752e-03 -8.041185e-03  1.039645e-02
## MEDHTA_T2          8.061119e-04  1.227364e-02 -4.983204e-03 -1.782546e-02
## GLU_T2             9.350781e-03 -6.278613e-02 -2.369142e-02 -4.506491e-03
## INS_T2            -8.617130e-02 -5.526547e-02  3.991158e-02 -4.610161e-02
## HOMA_T2           -5.565246e-02 -4.599978e-02  1.971273e-02 -2.910912e-02
## HBA1C_T2           7.862005e-03 -1.729714e-02 -2.986157e-02 -6.809452e-03
## HBA1C.mmol.mol_T2  8.137538e-03 -4.546425e-02 -5.886404e-02 -3.072465e-02
## PESO_T2           -5.438108e-02 -2.530322e-02  1.539625e-02  4.132320e-02
## bmi_T2            -3.165464e-02 -5.006560e-02  4.964663e-02  7.448623e-03
## CC_T2             -2.946218e-03  1.025572e-03 -9.422958e-03  9.332539e-04
## CINT_T2           -4.400599e-02 -3.305180e-02  1.025548e-02  2.355471e-02
## CAD_T2             6.756681e-03 -5.160421e-02  3.408813e-02  1.993775e-02
## TAD_T2             1.083174e-02  7.266658e-02 -3.619307e-02 -7.187794e-04
## TAS_T2             1.467240e-02  5.204716e-02 -1.080706e-03  1.248665e-02
## TG_T2             -1.893121e-02 -1.103048e-02 -9.115766e-02 -7.488817e-02
## COL_T2            -3.946427e-02 -1.768500e-02 -2.769848e-02  2.364854e-02
## LDL_T2            -3.110856e-02 -2.636761e-02 -6.486996e-02  1.775975e-03
## HDL_T2             3.263405e-02 -1.288514e-02  7.173996e-02  7.366983e-03
## VLDL_T2           -6.905812e-03  2.311292e-03 -5.320807e-02 -9.604348e-02
## PCR_T2             5.856280e-02  3.980025e-02 -1.919771e-01  7.815210e-02
## LEP_T2            -3.974982e-02  2.537677e-02  2.695993e-02  3.397929e-03
## ADIPO_T2          -3.786693e-02 -5.546065e-03  1.578712e-02  4.852057e-02
## GOT_T2             4.914469e-02 -4.697854e-02  1.271663e-01 -4.751020e-02
## GPT_T2             1.821548e-02  3.053827e-02  2.038778e-02 -8.054915e-02
## GGT_T2            -1.222554e-01 -1.528576e-01 -1.255513e-01 -3.409508e-02
## URICO_T2          -4.643969e-02 -2.643273e-02 -3.283768e-02 -1.010573e-02
## CREAT_T2          -2.408870e-03  5.417166e-03 -1.437668e-02  3.550719e-03
## UREA_T2           -1.256310e-02  7.118011e-02 -1.280093e-01 -2.501470e-02
## HIERRO_T2         -1.184192e-02  4.115598e-02  1.038736e-01 -6.096987e-02
## TRANSF_T2          7.376553e-02  6.868813e-03  1.468806e-04  5.878652e-02
## FERR_T2           -1.632554e-01  9.183291e-02 -8.653558e-03 -1.198349e-01
## Ile_T2             1.003857e-01 -9.713288e-02 -7.046952e-02 -4.035576e-02
## Leu_T2             4.144123e-02 -9.722142e-02 -2.195430e-02  4.406444e-03
## Val_T2             3.593813e-02 -7.803513e-02 -3.253781e-02 -4.633412e-02
## Ala_T2             4.003189e-02 -3.243588e-03  5.327163e-02  2.174263e-02
## Pro_T2            -3.572455e-02  4.700785e-02  5.104814e-02 -1.564948e-02
## Gly_T2            -8.513115e-03 -3.501778e-02 -4.605620e-02 -9.253253e-03
## Ser_T2            -2.139544e-03 -9.178226e-03  8.304373e-02  6.659456e-02
## Trp_T2            -1.673609e-02 -3.650011e-02 -2.192451e-02 -2.031219e-03
## Phe_T2             4.236728e-02 -1.124732e-01  1.164182e-02  9.561406e-02
## Met_T2             9.452130e-02  2.295926e-02  2.915914e-02 -1.407375e-01
## Orn_T2            -1.031977e-01  7.095966e-04  3.775721e-02  8.640909e-02
## Arg_T2             6.139015e-02 -1.879644e-02  1.188963e-02 -3.675991e-02
## His_T2            -1.122724e-02 -3.416954e-02  3.734464e-02  1.099532e-02
## Asn_T2             1.263931e-02  1.121431e-02 -3.413093e-02  1.094542e-02
## Asp_T2             8.035581e-02  8.681272e-02 -3.481744e-03  7.455982e-02
## Glu_T2             1.039534e-02 -5.446109e-02 -5.485602e-02  6.545485e-02
## Gln_T2            -8.750061e-03  9.716368e-03  7.335052e-03 -7.499125e-02
## Cit_T2            -3.539220e-02  4.675906e-02  1.818760e-02  1.923396e-02
## Tyr_T2             1.318725e-02 -6.008389e-02  6.994963e-02  2.502266e-02
## Thr_T2             9.025659e-02  7.646080e-02  3.731938e-02  2.537751e-02
## Lys_T2            -4.649238e-02  3.013603e-02  6.063760e-02  2.477337e-02
## Creatinine_T2      6.875635e-02 -6.931724e-03 -4.954919e-02  4.897313e-02
## Kynurenine_T2      8.403295e-03 -1.442436e-02 -1.046153e-02  6.039147e-03
## Putrescine_T2     -4.745542e-02  3.605097e-02 -1.104985e-01  1.164949e-04
## Sarcosine_T2       1.000703e-01  1.348478e-02  1.372094e-03  9.617832e-02
## Serotonin_T2       3.630437e-02  1.943064e-01  7.791274e-02 -1.354449e-01
## Taurine_T2         5.321597e-02 -3.649554e-02 -2.459143e-02  5.150173e-02
## SDMA_T2            3.531896e-02 -1.253089e-02 -1.044710e-02 -5.990132e-03
## C0_T2             -1.500933e-01  1.923320e-02 -6.641469e-03  1.045569e-02
## C2_T2              2.386822e-02 -2.627650e-03  1.325707e-02 -5.877731e-02
## C3.OH_T2          -1.660150e-04  5.662184e-04 -6.000623e-03  1.376144e-03
## C6..C4.1.DC._T2    5.991282e-02 -3.819600e-03  2.804719e-02  8.562766e-02
## C5.DC..C6.OH._T2  -1.594042e-02  4.360766e-04 -1.815285e-02  7.168817e-02
## C7.DC_T2          -9.896347e-02 -2.357557e-03 -2.298620e-02  2.240515e-02
## C8_T2             -1.815828e-04  3.271434e-03 -2.341619e-03  2.541412e-03
## C10_T2            -3.990294e-04  3.668712e-03 -1.983937e-03 -5.231246e-04
## C10.1_T2          -3.091855e-04  2.014319e-03 -4.844262e-03 -3.821902e-04
## C10.2_T2           8.728725e-04  2.646955e-03 -5.035899e-03  8.223303e-04
## C14.1_T2          -3.207274e-04  4.582067e-04 -3.996584e-03 -1.160395e-03
## C14.2_T2           9.360768e-04  1.351992e-03 -4.753815e-03  1.079183e-06
## C16.1_T2           4.533145e-04  1.130795e-03 -5.501983e-03 -6.033391e-05
## C16.2_T2          -2.749975e-04  1.027599e-03 -5.480526e-03 -1.049023e-03
## C16.2.OH_T2       -3.902568e-04  1.017807e-03 -5.462334e-03 -1.247418e-03
## C18.1_T2           1.333672e-03 -1.334800e-03 -4.967531e-03 -7.307867e-04
## C18.1.OH_T2        9.846712e-05  1.523486e-03 -5.403214e-03 -9.496299e-04
## C18.2_T2           8.949679e-04  1.259238e-03 -5.196709e-03  1.026003e-03
## lysoPC.a.C14.0_T2 -9.365629e-02 -5.840007e-02 -5.740143e-02 -1.368262e-01
## lysoPC.a.C16.0_T2 -9.533823e-02  5.666791e-03 -5.679068e-02  6.414596e-02
## lysoPC.a.C16.1_T2 -6.789421e-02  1.463903e-02 -3.346351e-02  3.302474e-02
## lysoPC.a.C17.0_T2 -3.040921e-02  2.437687e-03 -2.037008e-02  6.281676e-03
## lysoPC.a.C18.0_T2 -9.787438e-02 -1.008583e-02 -3.263450e-02  2.061985e-03
## lysoPC.a.C18.1_T2 -1.302669e-01 -3.204378e-03 -4.109207e-02  7.564884e-03
## lysoPC.a.C18.2_T2 -8.185391e-02  1.750199e-03 -2.279847e-02  2.038532e-02
## lysoPC.a.C20.3_T2 -4.623137e-02 -1.787683e-05 -1.310579e-02  9.188645e-04
## lysoPC.a.C20.4_T2 -5.547825e-02  3.456941e-02 -6.265633e-02 -2.464685e-02
## lysoPC.a.C24.0_T2 -5.621334e-03  1.355849e-03 -5.252476e-03  6.390051e-03
## lysoPC.a.C26.0_T2  1.530361e-02 -5.523155e-02  2.658450e-03  2.390633e-02
## lysoPC.a.C26.1_T2 -4.003085e-03  1.124614e-03 -3.835603e-03  2.734087e-03
## lysoPC.a.C28.0_T2  8.088059e-03 -1.460960e-02  3.324420e-02 -1.022739e-01
## lysoPC.a.C28.1_T2 -9.411705e-03  5.014138e-04 -2.751737e-03  1.069941e-02
## PC.aa.C24.0_T2     3.778500e-03  2.058863e-02 -6.064652e-02 -1.744685e-02
## PC.aa.C28.1_T2     1.759698e-02 -3.254769e-03  7.779857e-03  1.889940e-03
## PC.aa.C30.0_T2     1.290643e-02  3.718361e-03  8.994413e-03  3.644523e-03
## PC.aa.C32.0_T2     2.262820e-02 -1.859553e-02  2.569098e-02 -7.021967e-03
## PC.aa.C32.1_T2    -1.754019e-02  1.226913e-02  8.643266e-03  3.079659e-02
## PC.aa.C32.3_T2     4.686812e-04  1.839891e-04 -3.272473e-03  1.749659e-04
## PC.aa.C34.1_T2    -3.994193e-03 -4.627020e-02 -1.234824e-02 -4.846945e-02
## PC.aa.C34.2_T2     3.252849e-02 -2.524561e-02  2.010386e-02 -2.794630e-02
## PC.aa.C34.3_T2    -3.908675e-02  2.151033e-02 -1.646772e-02  1.637816e-02
## PC.aa.C34.4_T2    -2.316208e-03  3.320647e-03 -6.341178e-03 -1.822269e-03
## PC.aa.C36.0_T2    -1.840152e-02 -1.302808e-02 -7.246843e-03  1.532394e-02
## PC.aa.C36.1_T2    -5.545692e-02 -7.181744e-03  1.969921e-02 -2.056611e-02
## PC.aa.C36.2_T2    -3.138339e-02 -9.280604e-03  3.175182e-02 -3.678299e-02
## PC.aa.C36.3_T2    -3.275081e-02 -5.068542e-03  1.166071e-02 -9.815208e-04
## PC.aa.C36.4_T2     8.678055e-02 -1.352424e-03 -1.163083e-02 -1.120463e-01
## PC.aa.C36.5_T2     8.908044e-02 -5.656334e-02 -3.658508e-02 -6.173624e-02
## PC.aa.C38.0_T2    -9.998351e-03 -2.956397e-02 -1.810016e-03 -9.893530e-03
## PC.aa.C38.1_T2    -4.603703e-02 -3.823576e-02 -2.632578e-02 -2.270047e-02
## PC.aa.C38.3_T2    -3.199977e-02 -2.375347e-02  1.927997e-02 -1.871984e-02
## PC.aa.C38.4_T2     2.281620e-03 -1.174480e-02 -2.538176e-02 -1.231914e-01
## PC.aa.C38.5_T2    -2.441759e-02  7.440815e-04 -3.661474e-02 -7.519680e-02
## PC.aa.C38.6_T2     5.222342e-02 -5.479544e-02 -1.780555e-03 -1.147982e-01
## PC.aa.C40.1_T2    -2.027133e-02 -3.132274e-02  3.445065e-02 -6.237272e-02
## PC.aa.C40.2_T2    -1.978470e-02 -1.109860e-02 -1.055398e-02  2.874791e-02
## PC.aa.C40.3_T2    -2.594864e-02 -9.207968e-03 -9.741338e-03  2.974194e-02
## PC.aa.C40.4_T2    -2.514054e-02  1.150986e-03 -1.100483e-02  6.660198e-03
## PC.aa.C40.5_T2    -3.716915e-02  2.400775e-03 -2.501222e-02 -4.335309e-02
## PC.aa.C40.6_T2     1.908357e-02 -4.321728e-02 -1.675011e-02 -9.526325e-02
## PC.aa.C42.0_T2    -6.902895e-03 -3.196903e-03 -8.762809e-03  7.819547e-03
## PC.aa.C42.1_T2    -7.872628e-03 -1.620072e-03 -6.668701e-03  6.652441e-03
## PC.aa.C42.2_T2    -1.181522e-02 -3.377043e-03 -6.588114e-03  1.595073e-02
## PC.aa.C42.4_T2    -6.980322e-03 -1.353018e-03 -7.857742e-03  6.389045e-03
## PC.aa.C42.5_T2    -5.541659e-03 -5.396577e-04 -6.042674e-03  1.870209e-03
## PC.aa.C42.6_T2    -1.886848e-02 -4.284424e-02 -1.651880e-02  4.457640e-02
## PC.ae.C30.0_T2    -3.710566e-02 -6.573013e-02  3.240951e-02  2.259127e-03
## PC.ae.C32.1_T2     9.176575e-03 -1.305609e-02  4.993385e-04 -5.019867e-03
## PC.ae.C32.2_T2    -1.360720e-03 -3.032428e-03 -3.159555e-03  6.904608e-05
## PC.ae.C34.0_T2     5.155635e-03  5.774620e-04 -1.837535e-03 -1.472085e-03
## PC.ae.C34.1_T2    -1.021868e-02 -1.319330e-03  9.949986e-03  1.211967e-02
## PC.ae.C34.2_T2    -9.272281e-03 -1.187913e-02  4.458355e-03 -3.714092e-03
## PC.ae.C34.3_T2     9.962916e-03 -3.083606e-02  3.980064e-03 -1.181164e-02
## PC.ae.C36.0_T2    -1.665937e-03 -4.042974e-03 -7.377642e-03  1.444906e-03
## PC.ae.C36.1_T2    -5.998657e-02 -2.539602e-02 -1.598709e-02  7.600106e-02
## PC.ae.C36.2_T2    -2.034888e-02 -1.144047e-02 -7.447458e-05  1.552485e-02
## PC.ae.C36.3_T2    -1.390479e-02 -9.316155e-03  1.189622e-02  9.211049e-04
## PC.ae.C36.4_T2     9.315405e-03  5.966908e-03  5.608696e-03 -2.377272e-02
## PC.ae.C36.5_T2     3.439986e-03 -7.316017e-03 -1.203053e-02 -4.747148e-02
## PC.ae.C38.0_T2    -1.629010e-02 -2.186771e-03 -1.264818e-02 -1.036690e-02
## PC.ae.C38.2_T2    -4.410727e-02 -2.718390e-02 -1.119659e-02  6.464701e-02
## PC.ae.C38.3_T2    -3.909529e-02 -2.464807e-02 -7.035601e-03  6.908495e-02
## PC.ae.C38.4_T2     2.274098e-02  1.370104e-02  5.389871e-03 -1.923119e-02
## PC.ae.C38.5_T2     1.329868e-02 -8.180840e-03  2.399916e-02 -2.418652e-02
## PC.ae.C38.6_T2     3.475561e-03 -1.299780e-02 -2.469994e-03 -2.688441e-02
## PC.ae.C40.1_T2    -3.310003e-02 -3.688816e-03 -1.284723e-02  2.828099e-02
## PC.ae.C40.2_T2    -3.943195e-03 -1.661354e-02 -9.038716e-03  1.725591e-02
## PC.ae.C40.3_T2    -2.787244e-02 -2.010652e-02 -9.918548e-03  5.122218e-02
## PC.ae.C40.4_T2    -2.123979e-02 -5.679497e-03 -7.044808e-03  3.277380e-02
## PC.ae.C40.5_T2    -8.615418e-03 -8.009806e-03 -4.394572e-03  2.038005e-02
## PC.ae.C40.6_T2     1.394389e-02 -4.715064e-03 -8.658742e-03 -2.192161e-02
## PC.ae.C42.1_T2    -1.783160e-02 -5.196413e-03 -9.022386e-03  1.828677e-02
## PC.ae.C42.2_T2    -1.469556e-02 -6.237485e-03 -9.867524e-03  2.114717e-02
## PC.ae.C42.3_T2    -2.022567e-02 -7.640153e-03 -1.048333e-02  2.542849e-02
## PC.ae.C42.4_T2    -6.998390e-03  1.183103e-03 -6.298545e-03  1.679914e-02
## PC.ae.C42.5_T2    -3.959389e-03  3.885332e-03 -1.204315e-02  5.666786e-03
## PC.ae.C44.3_T2     4.091706e-02  8.664270e-02 -2.775953e-03  4.095166e-03
## PC.ae.C44.4_T2    -6.395072e-03 -1.056110e-03 -7.266386e-03  5.547778e-03
## PC.ae.C44.5_T2    -1.401818e-03  2.059569e-03 -2.124414e-02 -1.087812e-04
## PC.ae.C44.6_T2     5.904430e-04  5.268991e-03 -1.410377e-02  3.409129e-03
## SM..OH..C14.1_T2   3.366527e-02 -2.077587e-02  1.017706e-02 -1.840531e-02
## SM..OH..C16.1_T2   1.951528e-02 -9.783968e-03  6.572520e-03 -1.101476e-02
## SM..OH..C22.1_T2   1.884935e-02 -2.303099e-03  1.635293e-02 -2.690542e-02
## SM..OH..C22.2_T2   1.320650e-02 -3.092845e-02  1.368827e-02  2.916233e-03
## SM..OH..C24.1_T2   2.728188e-03 -4.509923e-04 -4.680979e-03 -2.906238e-03
## SM.C16.0_T2        6.615277e-02 -5.376878e-02  3.611990e-02 -2.929132e-02
## SM.C16.1_T2        8.904834e-02 -4.765072e-02  5.527723e-02 -3.073057e-02
## SM.C18.0_T2        9.910947e-02 -7.392411e-02  5.224966e-02 -4.347552e-02
## SM.C18.1_T2        7.748519e-02 -7.008898e-02  5.826868e-02 -4.969709e-02
## SM.C20.2_T2        1.846460e-03 -4.554238e-04 -3.021821e-03 -2.786772e-04
## SM.C24.0_T2        2.360632e-02 -1.531693e-02  6.666605e-04 -2.533367e-02
## SM.C24.1_T2        5.959837e-02 -6.845371e-02 -1.741256e-02 -4.567576e-02
## MEDDM_T4          -2.963370e-03  5.754962e-03 -3.768225e-03 -1.275726e-03
## MEDCOL_T4         -1.009762e-03  2.588154e-03 -1.444164e-02 -8.026152e-04
## MEDINF_T4         -1.252232e-03 -3.886012e-04  2.556351e-03  3.396193e-03
## MEDHTA_T4         -1.246162e-03  1.109517e-02 -1.726624e-02 -2.226849e-02
## GLU_T4            -3.561347e-02 -4.254452e-02 -7.877162e-02 -1.950549e-02
## INS_T4            -1.287056e-02 -3.939134e-02  1.306936e-01  6.291596e-02
## HOMA_T4           -1.179270e-02 -1.280699e-02  3.160142e-02  7.475613e-03
## HBA1C_T4           2.465549e-02 -2.781268e-02 -2.660195e-02 -2.773457e-03
## HBA1C.mmol.mol_T4  6.369202e-02 -7.490325e-02 -3.919187e-02 -1.313265e-02
## PESO_T4           -6.496623e-02 -7.592117e-03  1.591003e-02  4.639575e-02
## bmi_T4            -4.897977e-02 -2.726190e-02  4.791430e-02  1.541889e-02
## CC_T4             -4.464760e-03  2.957888e-03 -6.671185e-03 -7.523118e-03
## CINT_T4           -3.995109e-02 -2.975764e-02 -8.947627e-04  1.290638e-02
## CAD_T4             2.481504e-02 -5.354541e-02  6.695252e-03  6.343576e-02
## TAD_T4             4.548365e-02  1.214054e-02 -6.121800e-02  2.133890e-02
## TAS_T4             1.960126e-02  3.628588e-03 -3.699696e-02 -2.248791e-02
## TG_T4             -3.559311e-02 -1.529501e-02 -6.007111e-02  5.204960e-03
## COL_T4            -4.523528e-02  6.263504e-03 -1.076065e-02  4.672200e-02
## LDL_T4            -5.084284e-02 -6.422519e-03 -4.023937e-02  1.027389e-02
## HDL_T4             4.065310e-02 -2.642804e-02  5.991443e-02  2.338926e-02
## VLDL_T4            9.990379e-03  6.265937e-03  3.972424e-02  3.378397e-02
## PCR_T4             9.644593e-03 -2.159609e-02 -8.550667e-02  1.196478e-02
## LEP_T4            -3.669077e-02 -1.462298e-02  4.954674e-02 -1.047840e-02
## ADIPO_T4          -5.534688e-02  2.649450e-02  3.569385e-03  9.030047e-02
## GOT_T4             7.116236e-02 -3.123040e-02  1.673978e-01 -2.172159e-02
## GPT_T4             5.182040e-02 -5.091878e-03  1.104699e-01 -8.088319e-02
## GGT_T4            -9.891025e-02  2.055996e-02 -3.191489e-02  3.929081e-03
## URICO_T4          -4.705529e-02 -1.125586e-02 -1.456970e-02 -7.303651e-03
## CREAT_T4          -2.214782e-03  2.748368e-03 -1.199887e-02  2.998650e-03
## UREA_T4            3.108793e-03  4.932091e-03 -7.299718e-02 -2.505290e-02
## HIERRO_T4         -2.953150e-02  1.039663e-01  5.881875e-02  4.987392e-02
## TRANSF_T4          5.615200e-02 -8.735025e-03 -3.575571e-03  4.734691e-02
## FERR_T4           -1.887409e-01  7.540082e-02  6.221148e-02 -1.050779e-01
## Ile_T4             5.176401e-02  4.142027e-03 -4.056747e-03  1.153198e-02
## Leu_T4             4.850454e-02 -1.203267e-02  6.065030e-04 -2.050638e-04
## Val_T4             2.177057e-02 -5.302552e-02 -2.718385e-03 -5.083716e-02
## Ala_T4             5.110747e-02  1.770078e-02  2.922883e-02  3.156298e-03
## Pro_T4            -8.904453e-03  5.014361e-02  2.802227e-02 -9.338261e-02
## Gly_T4             1.891929e-02 -1.661869e-02 -8.955855e-02  2.853030e-02
## Ser_T4            -5.898379e-02 -5.989303e-02  1.839494e-01 -3.918096e-02
## Trp_T4             3.138003e-02 -7.409548e-02 -6.901881e-03 -2.668616e-02
## Phe_T4             6.850176e-02 -4.890943e-02  2.520552e-02  2.484411e-02
## Met_T4            -4.291478e-02  5.605554e-02  4.660805e-02  1.042586e-01
## Orn_T4            -1.324555e-02  5.547998e-03  1.974369e-02 -5.195545e-02
## Arg_T4             7.489732e-02  2.431003e-02  9.469686e-03 -2.534225e-02
## His_T4             4.326684e-02  4.416760e-02 -3.342290e-02  7.068245e-03
## Asn_T4             5.354641e-02  3.397750e-02 -1.258241e-02  4.207726e-02
## Asp_T4             8.256375e-03 -4.735445e-02  1.332316e-01 -5.408302e-03
## Glu_T4             2.400231e-02 -3.405638e-02 -2.262181e-02 -3.767125e-02
## Gln_T4            -6.194906e-02 -1.239127e-03  7.700237e-02  1.186514e-01
## Cit_T4             3.202020e-02  3.148642e-02 -3.302790e-02  3.749636e-02
## Tyr_T4             2.991269e-02 -1.353366e-02  5.505923e-02 -1.711026e-02
## Thr_T4             9.671230e-02  2.838351e-02  1.828151e-02 -4.089753e-03
## Lys_T4             7.334530e-02 -1.128077e-02 -2.640214e-02  8.137383e-02
## Creatinine_T4      5.132582e-02  1.243044e-02 -5.617787e-02  1.669197e-02
## Kynurenine_T4     -2.730343e-02 -1.847466e-02 -1.227162e-02  3.583644e-02
## Putrescine_T4     -5.446253e-04 -2.158068e-02 -4.729452e-02 -8.298705e-03
## Sarcosine_T4       3.734667e-02 -1.406874e-02 -1.710724e-02  1.081941e-01
## Serotonin_T4       4.575838e-02  1.963682e-01  6.932396e-02 -1.511642e-01
## Taurine_T4        -7.228980e-02 -1.418049e-01  3.191974e-02  4.162199e-02
## SDMA_T4            4.079096e-03  4.797180e-03 -1.344244e-02 -2.782485e-03
## C0_T4             -3.584924e-02 -1.590551e-02  4.073423e-02 -3.093013e-02
## C2_T4             -2.084882e-02  1.958785e-02 -1.944354e-03 -2.148055e-03
## C3.OH_T4           2.515937e-03 -1.584006e-03 -5.311720e-03 -3.434000e-03
## C6..C4.1.DC._T4    3.956603e-02 -2.091188e-02  2.262537e-02  4.061761e-02
## C5.DC..C6.OH._T4  -3.857755e-02 -3.629710e-02  3.755755e-02 -2.622176e-02
## C7.DC_T4          -4.347495e-02 -3.995431e-02  8.455304e-02 -6.109431e-02
## C8_T4              9.500520e-04 -5.612604e-04 -2.319623e-04 -4.295046e-03
## C10_T4             5.807210e-04 -9.306810e-05  1.931915e-04 -4.093998e-03
## C10.1_T4          -3.460423e-04  5.876391e-04 -4.592493e-03 -3.370593e-03
## C10.2_T4           4.937268e-05  1.593245e-04 -4.293878e-03 -1.162801e-03
## C14.1_T4           5.649514e-04  8.169459e-04 -3.380149e-03 -4.605279e-04
## C14.2_T4          -1.232382e-04  1.285401e-03 -3.965783e-03 -1.886381e-03
## C16.1_T4          -3.550093e-02 -1.538306e-02  1.275756e-03 -7.087088e-02
## C16.2_T4          -5.430206e-04  1.021309e-03 -4.246364e-03 -1.186287e-03
## C16.2.OH_T4       -3.511668e-02 -1.516488e-02  6.848548e-04 -7.107119e-02
## C18.1_T4          -4.058621e-04  7.239718e-04 -5.762999e-03 -5.359580e-04
## C18.1.OH_T4       -2.162845e-04  7.563391e-04 -4.836495e-03 -1.689858e-03
## C18.2_T4          -9.969098e-04  1.040148e-03 -5.207111e-03 -1.184258e-03
## lysoPC.a.C16.0_T4 -1.500528e-02  3.028293e-02 -5.261373e-02 -4.445840e-02
## lysoPC.a.C16.1_T4 -1.475630e-02  2.088092e-02 -4.753900e-02  2.191916e-02
## lysoPC.a.C17.0_T4 -2.977030e-03  1.028008e-03 -2.588104e-02 -3.425948e-02
## lysoPC.a.C18.0_T4 -6.292688e-02 -1.917215e-03 -5.118291e-02 -4.780054e-02
## lysoPC.a.C18.1_T4 -3.635266e-02 -3.618606e-04 -5.697115e-02  1.110732e-02
## lysoPC.a.C18.2_T4 -4.698036e-02  2.808918e-02  4.498640e-03  9.141209e-03
## lysoPC.a.C20.3_T4 -4.552917e-04 -1.630779e-03 -2.200788e-02  1.611703e-02
## lysoPC.a.C20.4_T4  4.203631e-03  7.370996e-02 -8.276289e-02 -3.052636e-02
## lysoPC.a.C24.0_T4  3.688759e-03 -4.718529e-03 -6.763800e-03 -3.847699e-03
## lysoPC.a.C26.0_T4  3.456902e-02 -6.212138e-02  2.127690e-03  1.204251e-02
## lysoPC.a.C26.1_T4  2.799536e-03 -8.775036e-04 -4.431155e-03 -3.180345e-03
## lysoPC.a.C28.0_T4  4.113247e-02  1.343145e-02 -3.980310e-02 -1.828396e-02
## lysoPC.a.C28.1_T4  5.416476e-03 -4.116920e-03 -6.312627e-03 -7.219282e-03
## PC.aa.C24.0_T4    -1.454696e-02  6.389067e-03 -1.436802e-02  4.787197e-02
## PC.aa.C28.1_T4     7.332123e-04 -1.184850e-02  2.099866e-02  3.998909e-03
## PC.aa.C30.0_T4     1.937616e-02  2.044104e-03  1.423889e-02  1.123421e-02
## PC.aa.C32.0_T4     1.935176e-02  2.357976e-02 -1.800722e-04 -7.264520e-03
## PC.aa.C32.1_T4     1.027950e-02  4.242482e-02 -7.140470e-03  4.521253e-02
## PC.aa.C32.3_T4    -9.141163e-04  2.032059e-03 -3.874716e-03 -6.955930e-04
## PC.aa.C34.1_T4    -9.043615e-03  3.190697e-03 -1.051438e-02  4.597056e-02
## PC.aa.C34.2_T4    -1.821035e-02  2.047105e-02  3.310523e-02  1.933254e-02
## PC.aa.C34.3_T4    -2.571070e-02  1.975993e-02  1.974746e-02  4.901624e-02
## PC.aa.C34.4_T4     1.631276e-03  5.272035e-03 -4.611263e-03 -9.621557e-04
## PC.aa.C36.0_T4     3.762923e-03 -4.420274e-03 -3.055163e-03 -2.052492e-02
## PC.aa.C36.1_T4    -3.873746e-02  4.221674e-03  4.388857e-02  1.122760e-01
## PC.aa.C36.2_T4    -5.894697e-02 -1.271242e-02  5.760406e-02  6.790256e-02
## PC.aa.C36.3_T4     1.661220e-03  5.393592e-03  1.338428e-02  9.357018e-02
## PC.aa.C36.4_T4     1.012471e-02  5.598967e-02 -3.305237e-02 -2.349966e-02
## PC.aa.C36.5_T4     6.227664e-04 -5.172429e-02 -3.017690e-03 -5.291586e-02
## PC.aa.C38.0_T4    -4.218488e-03 -2.767010e-02  1.846627e-03 -2.909064e-02
## PC.aa.C38.1_T4     1.091106e-02 -1.255861e-02 -2.032183e-03 -1.966418e-02
## PC.aa.C38.3_T4    -1.652286e-04 -1.795751e-02 -2.188948e-03  1.172520e-01
## PC.aa.C38.4_T4    -9.924405e-03  5.361878e-02 -3.975321e-02 -7.164609e-03
## PC.aa.C38.5_T4     3.813333e-03  3.360340e-02 -4.083679e-02  2.582135e-03
## PC.aa.C38.6_T4    -1.070665e-02 -2.748657e-02  3.807845e-02 -1.026598e-02
## PC.aa.C40.1_T4    -2.758569e-02 -1.816828e-02  2.841681e-03  3.397345e-02
## PC.aa.C40.2_T4     1.151710e-02 -6.580791e-03 -1.300279e-02 -1.767198e-02
## PC.aa.C40.3_T4     7.399126e-03 -7.016055e-03 -1.321395e-02 -1.425730e-02
## PC.aa.C40.4_T4     9.659133e-03  2.226419e-02 -2.455291e-02  3.192652e-03
## PC.aa.C40.5_T4    -1.420854e-02  2.446304e-02 -4.423761e-02  2.330266e-02
## PC.aa.C40.6_T4    -5.740346e-02 -4.675677e-02  2.867114e-02  1.172806e-02
## PC.aa.C42.0_T4     3.211356e-03 -4.088026e-03 -9.353651e-03 -7.517196e-03
## PC.aa.C42.1_T4     2.742538e-03 -2.035903e-03 -8.902093e-03 -8.707637e-03
## PC.aa.C42.2_T4     6.576323e-04 -2.606677e-03 -6.697159e-03 -5.433644e-03
## PC.aa.C42.4_T4     2.398073e-03  7.624295e-04 -8.742372e-03 -6.170174e-03
## PC.aa.C42.5_T4     1.559011e-03  9.681936e-04 -7.667086e-03 -4.869320e-03
## PC.aa.C42.6_T4    -5.025214e-02  2.408472e-02 -2.273495e-02 -8.674651e-04
## PC.ae.C30.0_T4     4.140842e-02 -4.154219e-02 -8.115773e-03  6.065665e-03
## PC.ae.C32.1_T4     8.613174e-03  1.223357e-02 -1.033448e-02 -6.536506e-04
## PC.ae.C32.2_T4     1.323237e-03 -9.585992e-04 -6.492289e-03 -5.849582e-03
## PC.ae.C34.0_T4     4.596985e-03  1.299996e-03 -4.108269e-03 -2.255847e-03
## PC.ae.C34.1_T4     1.752782e-02  5.648758e-03 -3.656550e-03  2.189463e-02
## PC.ae.C34.2_T4     8.172422e-03  9.429071e-03  1.327800e-02 -7.563946e-03
## PC.ae.C34.3_T4    -3.799324e-03  1.109603e-02  5.787021e-03 -2.800531e-02
## PC.ae.C36.0_T4     4.971041e-04 -1.900905e-03 -6.262126e-03 -7.064893e-03
## PC.ae.C36.1_T4     1.747832e-03 -7.143418e-03  4.010631e-03  7.404392e-03
## PC.ae.C36.2_T4     2.114275e-02 -1.774703e-02  3.098957e-02 -1.892833e-03
## PC.ae.C36.3_T4    -5.987296e-03 -3.020419e-03  5.717328e-03  4.800440e-03
## PC.ae.C36.4_T4     1.217160e-02  6.035299e-02 -1.276623e-02 -8.089785e-03
## PC.ae.C36.5_T4     1.908077e-03  5.015545e-02 -3.337034e-02 -4.710168e-02
## PC.ae.C38.0_T4    -8.790066e-03 -6.080608e-03  1.918166e-03 -4.500598e-03
## PC.ae.C38.2_T4     1.260397e-02 -3.357180e-02 -5.125020e-03 -3.154795e-02
## PC.ae.C38.3_T4     4.180329e-02 -2.449110e-02 -2.180616e-02 -4.038967e-02
## PC.ae.C38.4_T4     3.907820e-02  3.292004e-02 -1.712313e-02 -9.444771e-03
## PC.ae.C38.5_T4     2.307605e-02  5.220559e-02 -3.252722e-02  1.712560e-02
## PC.ae.C38.6_T4     2.168232e-03  8.302269e-03 -1.367573e-02 -8.646555e-03
## PC.ae.C40.1_T4     2.330914e-03 -8.867139e-03 -7.667027e-03 -2.043705e-02
## PC.ae.C40.2_T4     2.174075e-02 -2.686093e-02 -1.267464e-02 -2.265496e-02
## PC.ae.C40.3_T4     3.304654e-02 -2.807556e-02 -1.766457e-02 -4.773803e-02
## PC.ae.C40.4_T4     2.864004e-02 -2.423660e-04 -1.650785e-02 -3.204556e-02
## PC.ae.C40.5_T4     1.659836e-02  4.029261e-03 -1.338881e-02 -4.077159e-03
## PC.ae.C40.6_T4     5.776207e-03 -7.089510e-03 -2.360621e-03 -8.062906e-03
## PC.ae.C42.1_T4     6.148986e-03 -2.878741e-03 -1.275110e-02 -1.428392e-02
## PC.ae.C42.2_T4     4.732492e-03 -6.458944e-03 -1.128253e-02 -1.062454e-02
## PC.ae.C42.3_T4    -1.752186e-04 -1.035665e-02 -6.158558e-03 -4.124481e-03
## PC.ae.C42.4_T4     9.254661e-03 -4.073508e-03 -7.860874e-03 -2.467861e-03
## PC.ae.C42.5_T4     1.200472e-02  1.086484e-02 -2.195848e-02  2.353944e-04
## PC.ae.C44.3_T4     3.781439e-04 -1.050858e-03 -6.770637e-03 -1.058234e-03
## PC.ae.C44.4_T4     1.392722e-03 -1.333537e-03 -8.575811e-03 -1.468193e-03
## PC.ae.C44.5_T4     1.470236e-02 -3.289855e-03 -2.837573e-02  9.999868e-03
## PC.ae.C44.6_T4     5.865092e-03  4.838563e-03 -2.019941e-02 -4.824050e-03
## SM..OH..C14.1_T4  -8.085517e-04 -1.394831e-02  5.109055e-03 -7.773918e-03
## SM..OH..C16.1_T4   5.112711e-03 -1.177992e-02  5.538557e-03  5.817460e-04
## SM..OH..C22.1_T4   1.271011e-02 -3.368750e-03  1.451929e-02  2.676360e-02
## SM..OH..C22.2_T4   2.664727e-02 -3.945542e-02  3.105138e-03  1.714058e-02
## SM..OH..C24.1_T4   3.607805e-04 -8.097127e-04 -2.837958e-03 -1.467274e-03
## SM.C16.0_T4       -2.865638e-03 -1.003923e-02  1.826795e-02  3.383555e-02
## SM.C16.1_T4       -2.556143e-02 -2.491917e-02  5.221987e-02  2.914989e-02
## SM.C18.0_T4        7.557248e-03 -2.816922e-02  7.063108e-02  7.668434e-02
## SM.C18.1_T4       -1.110620e-02 -3.020417e-02  6.108626e-02  4.501951e-02
## SM.C20.2_T4        1.445860e-03 -3.337010e-04 -3.335444e-03  1.377575e-03
## SM.C24.0_T4       -8.474767e-03  8.847687e-03 -3.645598e-03  2.930436e-02
## SM.C24.1_T4        1.174740e-02 -7.009045e-02  3.905329e-03  6.463422e-02
## MEDDM_T5          -1.082724e-02  2.716964e-03 -2.887446e-02 -1.550444e-02
## MEDCOL_T5         -1.082724e-02  2.716964e-03 -2.887446e-02 -1.550444e-02
## MEDINF_T5         -1.407457e-02  6.078103e-04 -2.135812e-02 -8.639601e-03
## MEDHTA_T5         -1.320338e-02  7.551553e-03 -2.699927e-02 -1.526716e-02
## GLU_T5             1.593337e-02  2.258016e-02 -3.593125e-02  1.057958e-02
## INS_T5             3.637082e-02  9.222479e-03  3.109441e-02  6.327813e-03
## HOMA_T5            6.861174e-03  7.239727e-03  3.033774e-03  1.590169e-03
## HBA1C_T5           2.319046e-02 -1.649563e-02 -3.635850e-02 -1.165799e-04
## HBA1C.mmol.mol_T5  5.933693e-02 -3.686090e-02 -7.293033e-02 -4.188524e-03
## PESO_T5            2.526089e-02  2.618555e-02  3.738233e-02  7.551976e-02
## bmi_T5             3.819461e-02  9.534181e-03  6.171513e-02  4.534238e-02
## CC_T5              4.077414e-04 -1.415735e-03 -8.727145e-03 -1.566226e-03
## CINT_T5            4.143594e-02  6.225134e-03  2.513947e-02  4.691841e-02
## CAD_T5             4.956387e-02  1.208554e-02  6.053630e-02  6.961486e-02
## TAD_T5             1.186149e-02  2.761942e-02 -4.430733e-02 -3.390019e-02
## TAS_T5             2.959896e-02  7.734190e-03 -3.419118e-03 -2.132550e-02
## TG_T5             -3.897188e-02  6.768212e-02 -1.218975e-02  6.267905e-02
## COL_T5            -3.126460e-03  3.558914e-02 -1.766657e-02  1.972132e-02
## LDL_T5            -2.169419e-02  1.792490e-02 -6.559580e-02 -2.143061e-02
## HDL_T5             8.426584e-02  7.329597e-04  8.533006e-02  2.839523e-02
## VLDL_T5            1.873769e-02  4.834002e-02  6.317885e-02  5.878735e-02
## PCR_T5             1.267620e-02  5.304451e-02 -8.897455e-02  4.649102e-02
## LEP_T5             8.288139e-03  3.294235e-02  2.645899e-02 -8.494065e-03
## ADIPO_T5          -3.023114e-02  3.668397e-02  3.546695e-02  5.171272e-02
## GOT_T5             9.033558e-02  2.507465e-03  1.145424e-01  2.548381e-02
## GPT_T5             8.450890e-02  3.256861e-02  7.842056e-02 -2.414958e-02
## GGT_T5            -3.557564e-03 -4.734071e-02 -2.406235e-02 -6.231113e-03
## URICO_T5           1.325283e-02 -6.624057e-03 -9.136216e-03  1.078658e-02
## CREAT_T5          -3.217406e-03  4.430666e-03 -5.994361e-03  5.725033e-03
## UREA_T5           -4.296566e-02 -3.504833e-02 -1.203151e-01  5.452864e-02
## HIERRO_T5         -3.355250e-02 -3.013288e-02 -2.156559e-02  1.207686e-02
## TRANSF_T5          1.173092e-01  2.820142e-02  1.784916e-03  4.299777e-02
## FERR_T5           -1.512618e-01  1.037964e-01  3.275237e-03 -7.730720e-02
## Ile_T5             7.887115e-02 -7.188085e-03 -4.881575e-02 -2.637823e-02
## Leu_T5             4.055398e-02 -4.825904e-02 -7.521742e-02  3.208108e-02
## Val_T5             6.714787e-02 -7.414388e-02 -1.102458e-01 -1.371006e-02
## Ala_T5             5.677335e-02  9.678885e-03 -8.571009e-03 -1.502031e-02
## Pro_T5             5.340331e-02  2.666044e-02 -2.320341e-02 -2.971552e-02
## Gly_T5            -2.418874e-02 -1.019911e-01 -1.422973e-01  1.431207e-02
## Ser_T5             1.077362e-02 -3.863298e-02 -1.711425e-03  2.443934e-03
## Trp_T5             1.174078e-01 -8.825179e-03 -9.313282e-02  3.170049e-03
## Phe_T5             6.474094e-02 -5.999250e-02 -5.553184e-02  7.561041e-02
## Met_T5             8.154424e-02  1.376329e-02 -2.348760e-02 -2.496780e-02
## Orn_T5            -1.739963e-02 -2.805629e-02 -1.105739e-02  1.340920e-02
## Arg_T5             6.173632e-02  1.894404e-03 -4.257213e-02 -6.530664e-02
## His_T5             9.532990e-03 -9.889437e-03 -5.150260e-02  3.613048e-03
## Asn_T5             5.381699e-02 -4.945631e-03 -3.371726e-02  1.037367e-03
## Asp_T5             7.164767e-02  1.250238e-01 -4.212546e-03  4.898193e-02
## Glu_T5             6.077581e-02 -3.668342e-02 -3.113666e-02 -6.761728e-02
## Gln_T5            -4.387029e-02  4.596215e-03 -4.824594e-02  2.967048e-02
## Cit_T5             5.608761e-02  3.589517e-02 -1.344817e-02 -3.186934e-02
## Tyr_T5             5.687923e-02 -2.059850e-02 -3.692183e-02  2.290953e-02
## Thr_T5             1.208512e-01  1.644566e-02 -6.631512e-02  3.781645e-03
## Lys_T5             4.163185e-02 -2.538073e-02  4.232822e-03 -4.219093e-02
## Creatinine_T5      3.067504e-02  3.700952e-02 -5.904528e-03  4.219677e-02
## Kynurenine_T5      1.034619e-01  8.805927e-02 -2.010897e-02 -6.162148e-02
## Putrescine_T5     -3.480266e-02 -2.556432e-03 -7.791559e-02 -1.057361e-02
## Sarcosine_T5       4.591262e-02  2.481420e-02  1.040022e-02  1.284915e-01
## Serotonin_T5       5.492071e-02  1.754091e-01  9.444887e-02 -1.560732e-01
## Taurine_T5        -2.109221e-02 -8.867027e-02 -7.574716e-02  3.185287e-02
## SDMA_T5            4.952849e-03 -3.750518e-03 -8.369683e-03  2.875524e-05
## C0_T5              7.074340e-02 -4.407271e-02  3.072072e-03 -1.078739e-01
## C2_T5             -1.336890e-02 -4.103824e-02 -2.415932e-03  1.360997e-02
## C3.OH_T5           2.755685e-04  9.650116e-04 -8.839217e-03  1.276385e-04
## C6..C4.1.DC._T5    6.978304e-02  1.046737e-02  3.565767e-02  8.782238e-02
## C5.DC..C6.OH._T5   2.734851e-02  8.913988e-02  4.393648e-02 -7.964627e-02
## C7.DC_T5          -2.247382e-02 -2.080318e-02  5.477337e-02  3.375473e-02
## C8_T5              1.309397e-03  1.972525e-03 -8.888040e-03  9.240959e-04
## C10_T5             3.293169e-03  3.495705e-03 -6.233288e-03  2.230721e-03
## C10.1_T5           3.498937e-02  4.393752e-02  1.593568e-02 -2.358467e-02
## C10.2_T5          -2.137309e-04  8.530129e-04 -6.362194e-03  9.046966e-05
## C14.1_T5          -2.524459e-04  5.534664e-05 -7.005526e-03  3.814462e-04
## C14.2_T5          -4.054586e-04  9.410324e-04 -6.485425e-03 -3.964931e-04
## C16.1_T5          -3.081682e-04  1.504487e-03 -5.729879e-03  7.205978e-05
## C16.2_T5          -4.174391e-04  1.172119e-03 -5.690396e-03 -1.028407e-03
## C16.2.OH_T5        1.487932e-02 -1.971082e-02 -4.787517e-02  3.576454e-02
## C18.1_T5          -5.733491e-04 -4.275764e-04 -6.244103e-03 -1.226126e-03
## C18.1.OH_T5       -3.877681e-04  1.214227e-03 -5.872578e-03 -1.061695e-03
## C18.2_T5          -4.642825e-04  1.582082e-03 -5.346257e-03 -8.980237e-04
## lysoPC.a.C16.0_T5 -5.471362e-02  1.645155e-02 -2.053319e-02 -1.382439e-02
## lysoPC.a.C16.1_T5 -6.792216e-02  2.515535e-03 -2.330933e-02  3.142821e-02
## lysoPC.a.C17.0_T5 -1.856638e-02  5.256809e-03 -3.140394e-02 -1.866769e-02
## lysoPC.a.C18.0_T5 -5.296130e-02 -1.483974e-02 -3.396037e-02 -4.106450e-02
## lysoPC.a.C18.1_T5 -5.255595e-02 -2.239905e-02 -1.627358e-02 -3.640602e-02
## lysoPC.a.C18.2_T5 -3.282580e-02  2.122661e-02 -3.527273e-02 -7.182280e-02
## lysoPC.a.C20.3_T5 -2.113241e-02 -9.989028e-03 -2.393847e-02 -4.138575e-02
## lysoPC.a.C20.4_T5 -4.684367e-02  2.087319e-02 -2.536830e-02 -1.120820e-01
## lysoPC.a.C24.0_T5 -1.097509e-03  3.242205e-03 -8.497102e-03 -9.847666e-04
## lysoPC.a.C26.0_T5 -1.830063e-03  6.116493e-03 -4.985887e-03 -2.699504e-04
## lysoPC.a.C26.1_T5 -1.909900e-03  5.266169e-03 -7.372260e-03 -4.421433e-03
## lysoPC.a.C28.0_T5 -5.166134e-02  4.255938e-03  7.223814e-02 -8.609684e-02
## lysoPC.a.C28.1_T5 -2.527876e-03  4.516208e-03 -3.164599e-03 -2.336600e-03
## PC.aa.C24.0_T5    -1.974045e-02  1.314509e-01  3.624454e-02 -4.787912e-02
## PC.aa.C28.1_T5     1.922035e-03 -1.973625e-03  1.443536e-04  2.437260e-02
## PC.aa.C30.0_T5     1.448301e-02  1.475720e-02  9.323869e-03  1.830472e-02
## PC.aa.C32.0_T5    -3.312024e-02 -1.496585e-03  2.280646e-02  3.102177e-02
## PC.aa.C32.1_T5    -5.405710e-02  3.182436e-02  4.903303e-02  9.931536e-02
## PC.aa.C32.3_T5    -7.091728e-04  1.092055e-03 -5.295728e-03 -7.835971e-04
## PC.aa.C34.1_T5    -4.599543e-02 -4.230836e-03  3.813402e-02  5.768874e-02
## PC.aa.C34.2_T5    -3.899521e-03  2.922977e-02  3.090340e-02  3.576069e-02
## PC.aa.C34.3_T5     2.622451e-03  4.670333e-02  2.049960e-02  6.111297e-02
## PC.aa.C34.4_T5     4.354316e-03  4.119463e-03 -4.112614e-03  1.295607e-05
## PC.aa.C36.0_T5    -5.894989e-04  6.127455e-03  3.811406e-03  2.316950e-03
## PC.aa.C36.1_T5    -1.901234e-02 -2.694626e-02  6.598997e-02  2.916175e-02
## PC.aa.C36.2_T5    -7.120586e-03 -7.879003e-03  3.244387e-02  1.532605e-02
## PC.aa.C36.3_T5     5.902780e-03  6.395788e-03  1.913230e-02  3.694396e-02
## PC.aa.C36.4_T5    -2.225722e-02  3.084513e-02  3.031005e-02 -2.073018e-02
## PC.aa.C36.5_T5     6.062396e-02 -3.148680e-02  2.398368e-02 -2.264831e-02
## PC.aa.C38.0_T5    -1.509765e-02 -3.907219e-02  1.629524e-03  1.254236e-03
## PC.aa.C38.1_T5    -5.814336e-03 -7.794358e-04 -1.614005e-03  1.175180e-03
## PC.aa.C38.3_T5     9.565654e-03 -3.195084e-02  1.359375e-02  3.228411e-02
## PC.aa.C38.4_T5    -3.991045e-02 -1.812893e-02 -9.072570e-03 -4.697243e-02
## PC.aa.C38.5_T5    -4.079310e-02 -5.723186e-04  1.255423e-02 -3.181502e-02
## PC.aa.C38.6_T5    -1.792001e-02 -3.169056e-02  1.599709e-02 -5.276672e-04
## PC.aa.C40.1_T5    -3.338536e-02 -1.984812e-02  7.715903e-02 -3.863455e-02
## PC.aa.C40.2_T5    -3.909371e-03  7.432887e-04 -4.173958e-03  4.653526e-03
## PC.aa.C40.3_T5    -9.260919e-03  2.508676e-03 -2.902500e-03  1.019346e-02
## PC.aa.C40.4_T5    -1.606629e-02  1.227898e-02 -2.026298e-03  3.595386e-03
## PC.aa.C40.5_T5    -4.020912e-02  6.639409e-03 -4.564533e-03 -1.816658e-02
## PC.aa.C40.6_T5    -2.679179e-02 -6.181423e-02 -1.399013e-02 -1.465100e-02
## PC.aa.C42.0_T5    -1.403202e-03 -2.868960e-03 -6.368567e-03  2.749895e-03
## PC.aa.C42.1_T5    -2.935291e-03 -7.127344e-04 -6.050230e-03  1.739649e-03
## PC.aa.C42.2_T5    -3.976534e-03  5.075848e-04 -4.333639e-03  3.846843e-03
## PC.aa.C42.4_T5    -3.377493e-03  1.240568e-03 -5.268685e-03  1.204601e-03
## PC.aa.C42.5_T5    -3.364013e-03  1.017347e-03 -4.890348e-03  2.318342e-03
## PC.aa.C42.6_T5     4.159511e-02  8.156988e-02 -6.555945e-03 -3.000682e-02
## PC.ae.C30.0_T5     4.972991e-02  9.226792e-02 -3.498840e-03  1.417795e-03
## PC.ae.C32.1_T5     2.410719e-03 -7.045593e-03 -9.124176e-03  8.737994e-03
## PC.ae.C32.2_T5    -3.108654e-03 -3.023928e-03 -6.308563e-03  1.786993e-03
## PC.ae.C34.0_T5     1.212609e-03  1.508917e-04 -4.971144e-03  3.762786e-04
## PC.ae.C34.1_T5    -7.530571e-03 -5.118293e-03 -9.498190e-03  4.296218e-02
## PC.ae.C34.2_T5     1.636470e-02 -1.503742e-02  3.645595e-03  1.151942e-03
## PC.ae.C34.3_T5     2.339873e-02 -9.549721e-03  1.337139e-02 -1.446075e-02
## PC.ae.C36.0_T5    -1.170980e-03 -1.973370e-03 -2.125910e-03  1.020281e-03
## PC.ae.C36.1_T5    -1.336667e-02  1.060894e-02  8.798051e-03  2.418592e-02
## PC.ae.C36.2_T5    -1.907588e-02  1.858680e-02  1.243998e-02  2.333826e-02
## PC.ae.C36.3_T5     8.008667e-03 -7.199332e-03 -3.255585e-04  8.810628e-03
## PC.ae.C36.4_T5     6.406507e-03  1.208116e-02  2.278356e-02 -3.373778e-02
## PC.ae.C36.5_T5    -1.030469e-02  4.912747e-03 -1.540687e-03 -5.463286e-02
## PC.ae.C38.0_T5    -7.587657e-04 -5.709134e-03 -7.422416e-03 -1.040486e-03
## PC.ae.C38.2_T5    -2.099311e-02 -5.637477e-04 -7.078014e-03  2.771965e-02
## PC.ae.C38.3_T5     3.143354e-02 -1.686693e-02 -1.134667e-02 -3.742623e-02
## PC.ae.C38.4_T5     5.370301e-03  2.249926e-02 -1.026004e-02 -5.107049e-03
## PC.ae.C38.5_T5    -1.422989e-04 -2.420935e-02  8.095097e-03 -1.715914e-02
## PC.ae.C38.6_T5    -6.802001e-03 -2.724048e-02  1.359874e-04 -1.948833e-02
## PC.ae.C40.1_T5    -6.598398e-03  6.138561e-03 -1.194759e-04 -7.372958e-03
## PC.ae.C40.2_T5     1.972888e-03 -1.076203e-02 -9.200504e-03 -1.152093e-03
## PC.ae.C40.3_T5     2.569959e-02 -2.394463e-02 -1.524560e-02 -3.500761e-02
## PC.ae.C40.4_T5     6.658703e-03 -4.151128e-03 -9.376796e-03 -7.457102e-03
## PC.ae.C40.5_T5     2.132805e-02 -1.140110e-02 -6.251833e-03 -2.610947e-02
## PC.ae.C40.6_T5     4.960592e-03 -7.936952e-03 -6.000405e-03 -6.772828e-03
## PC.ae.C42.1_T5    -2.438481e-03  8.003791e-04 -6.724632e-03 -2.484172e-03
## PC.ae.C42.2_T5    -2.041887e-03 -1.155705e-03 -7.414620e-03  3.828835e-03
## PC.ae.C42.3_T5    -4.452670e-03 -2.282944e-03 -7.194325e-03  7.546645e-03
## PC.ae.C42.4_T5    -1.365282e-03  2.624759e-03 -9.843153e-03  8.121802e-03
## PC.ae.C42.5_T5     1.239169e-02 -1.361381e-02 -2.078686e-02 -1.031392e-02
## PC.ae.C44.3_T5    -3.353828e-03  2.143957e-03 -4.924470e-03  1.627147e-03
## PC.ae.C44.4_T5     2.303713e-04  3.227515e-04 -5.864993e-03  6.018613e-03
## PC.ae.C44.5_T5     7.859187e-04 -7.644451e-03 -2.689118e-02  1.021455e-02
## PC.ae.C44.6_T5    -2.164362e-03 -2.675255e-03 -1.535366e-02  3.897754e-03
## SM..OH..C14.1_T5  -1.626661e-02 -5.471280e-03 -1.555359e-02  1.216396e-02
## SM..OH..C16.1_T5  -3.489231e-03  2.715945e-04 -2.363452e-03 -2.716691e-04
## SM..OH..C22.1_T5   2.977165e-02  2.589509e-02  8.844331e-03  2.166580e-02
## SM..OH..C22.2_T5   2.959706e-02 -1.511184e-02  1.097070e-03  2.479967e-02
## SM..OH..C24.1_T5   3.277646e-03  7.960143e-04 -5.219787e-03  1.034501e-04
## SM.C16.0_T5       -8.042288e-03 -6.162363e-03 -2.033084e-03  1.674143e-02
## SM.C16.1_T5        3.355513e-03 -4.088337e-03  3.831553e-02  4.858587e-02
## SM.C18.0_T5       -3.086206e-02 -1.593002e-02  5.534244e-02  4.877763e-02
## SM.C18.1_T5       -1.812959e-02 -4.730669e-02  4.855678e-02  3.976350e-02
## SM.C20.2_T5       -5.730904e-04  2.264618e-03 -4.415141e-03  1.282638e-03
## SM.C24.0_T5        2.202035e-02  5.786355e-02  1.051895e-02  3.888651e-02
## SM.C24.1_T5       -5.112339e-03 -1.654842e-02  1.111090e-03  1.824336e-02
##                            PC17          PC18          PC19          PC20
## GLU_T0            -5.490559e-02 -4.092355e-02 -2.700875e-02 -1.092410e-02
## INS_T0             2.152062e-02 -3.112322e-02 -7.659210e-02  5.312025e-02
## HOMA_T0           -5.838586e-03 -3.607597e-02 -5.470274e-02  2.363576e-02
## HBA1C_T0           4.507277e-03  7.368920e-03  1.416281e-03  1.651632e-02
## HBA1C.mmol.mol_T0 -2.925114e-03  4.367383e-03 -1.865977e-02  2.629169e-02
## PESO_T0            3.777103e-02  1.999627e-02 -3.415349e-02  2.010457e-03
## bmi_T0             5.810855e-02  3.762993e-03 -5.293962e-02  1.250522e-02
## CC_T0             -1.150354e-03  2.958652e-03  3.072767e-03  1.662323e-03
## CINT_T0           -5.708371e-03  4.021221e-02  5.715867e-04 -2.095159e-03
## CAD_T0             3.437720e-02  1.671407e-02 -4.252091e-03  1.787218e-02
## TAD_T0             4.804160e-02 -4.603080e-02  6.501406e-02 -1.300588e-02
## TAS_T0             9.848741e-02  4.699694e-03 -1.543890e-03 -2.030729e-02
## TG_T0             -3.521471e-02  7.168451e-02  1.574124e-02 -5.895809e-02
## COL_T0             5.081130e-03 -3.747983e-02 -3.208476e-02 -5.746933e-02
## LDL_T0            -2.144503e-02 -5.361011e-02 -1.844223e-02 -2.198473e-02
## HDL_T0             1.147506e-01 -5.890404e-02 -2.898241e-02 -8.397055e-02
## VLDL_T0           -3.565936e-02  7.232983e-02  1.637269e-02 -5.927650e-02
## PCR_T0            -5.844114e-02 -1.024094e-01  2.876870e-03 -3.309160e-02
## LEP_T0             7.243700e-02 -8.725377e-02 -1.250407e-01 -4.302222e-02
## ADIPO_T0          -4.398236e-02  2.860206e-02  2.417553e-02 -2.621730e-02
## GOT_T0             6.200685e-03 -1.111685e-01  8.660861e-02 -8.368214e-02
## GPT_T0            -1.251327e-01 -1.588052e-01  3.588752e-02  6.251228e-02
## GGT_T0             3.295591e-03 -6.950814e-02  2.312116e-03 -1.021958e-02
## URICO_T0           2.206526e-02 -2.993976e-03 -2.055602e-02 -8.002801e-03
## CREAT_T0           3.515568e-04 -1.780627e-03  9.066594e-03  1.376834e-04
## UREA_T0            1.804580e-02 -1.011850e-01 -8.791940e-02  4.307207e-02
## HIERRO_T0         -5.978473e-02  3.575671e-02  1.555624e-03 -8.945251e-02
## TRANSF_T0          1.506982e-02 -3.168481e-02 -8.212400e-03 -3.623487e-02
## FERR_T0            2.340281e-02  2.215590e-02  2.075967e-02 -2.552899e-02
## Ile_T0            -2.865453e-02 -1.453687e-01  2.189191e-02  2.393135e-02
## Leu_T0            -5.859747e-02 -1.497893e-01  1.095779e-02 -2.821243e-03
## Val_T0            -4.385671e-02 -9.245595e-02 -1.730010e-02 -2.040455e-03
## Ala_T0            -1.953238e-02  9.540596e-03 -4.031451e-02 -2.403085e-02
## Pro_T0             5.083875e-02  5.240022e-02 -9.887717e-03 -9.887871e-02
## Gly_T0            -3.676431e-02  8.702232e-02  1.044961e-01  9.478790e-02
## Ser_T0             4.072374e-02 -6.718970e-02  1.638522e-01  2.923717e-02
## Trp_T0             4.902278e-02 -4.258436e-02  6.106003e-02  8.666461e-03
## Phe_T0            -1.382246e-02 -8.006035e-02 -7.788665e-02 -6.834349e-03
## Met_T0             6.443877e-02 -3.289585e-02 -3.822541e-02  2.303215e-02
## Orn_T0             5.004120e-02 -1.537992e-01  2.315806e-02 -2.271006e-02
## Arg_T0             5.697562e-02  1.243153e-02  2.078512e-02 -5.648961e-03
## His_T0            -3.727264e-02  7.022382e-02  3.873787e-02 -2.472786e-02
## Asn_T0            -3.383845e-02 -4.219928e-02  6.834984e-02 -4.697194e-02
## Asp_T0             2.958171e-02 -1.054945e-02  3.272341e-02 -4.050921e-02
## Glu_T0             4.334157e-02 -1.386181e-02  2.155820e-02  7.586685e-03
## Gln_T0            -2.940615e-02  4.975070e-02  3.493979e-02 -1.976730e-02
## Cit_T0            -3.850184e-02 -8.457599e-03 -2.043511e-02  2.442743e-02
## Tyr_T0             2.759608e-02 -5.393141e-02 -3.682083e-02 -8.961691e-02
## Thr_T0             8.924578e-03  2.119175e-02  1.197457e-01 -7.346313e-02
## Lys_T0             2.562233e-02 -4.942886e-02 -5.091650e-03  4.401607e-02
## Creatinine_T0     -2.553138e-02  3.068423e-02  9.040506e-02  3.195362e-02
## Kynurenine_T0     -7.661044e-03 -9.114695e-03 -1.865947e-03 -1.147008e-02
## Putrescine_T0     -1.065581e-02 -2.456077e-03 -1.471124e-01 -2.754960e-02
## Sarcosine_T0       8.185517e-03  1.196955e-03 -9.202355e-03 -1.701965e-02
## Serotonin_T0       1.576485e-01 -2.065110e-02 -1.830018e-03  6.784788e-02
## Taurine_T0         3.203646e-02 -4.971706e-02  9.174274e-02  2.989000e-02
## SDMA_T0           -4.645847e-03 -3.213100e-03  8.343395e-03  5.236851e-03
## C0_T0              7.327077e-02  2.682715e-02  4.116881e-02  3.196716e-02
## C2_T0             -6.140331e-02 -1.108695e-01  1.142423e-01  1.639608e-01
## C3.OH_T0          -5.673324e-04 -1.639289e-03  5.337222e-03  1.520526e-03
## C6..C4.1.DC._T0    9.429948e-02  3.741788e-02  4.541936e-02  8.629913e-03
## C5.DC..C6.OH._T0  -3.075516e-02 -9.096595e-02 -1.385846e-01 -3.347217e-02
## C7.DC_T0          -5.254710e-02 -1.084659e-01 -6.569024e-02  5.978080e-02
## C8_T0             -2.357011e-03 -1.471525e-04 -2.899519e-04 -2.465910e-03
## C10_T0             1.682372e-04 -1.227066e-05  7.050194e-03  2.457647e-03
## C10.1_T0          -8.296375e-04  1.391292e-03  2.422097e-03 -3.764435e-04
## C10.2_T0          -4.132659e-04  6.273444e-04  4.136222e-03  8.660498e-04
## C14.1_T0          -2.702882e-04 -2.574005e-04  6.340751e-03  1.651799e-03
## C14.2_T0          -5.235453e-04  7.735441e-04  4.385455e-03  1.158334e-04
## C16.1_T0          -6.488350e-04  7.493572e-04  4.325097e-03  5.345033e-04
## C16.2_T0          -8.403745e-04  4.441637e-04  3.762748e-03  1.224126e-03
## C16.2.OH_T0       -9.070440e-04  4.199846e-04  3.055061e-03  1.448113e-03
## C18.1_T0          -1.148225e-03 -1.389285e-03  5.629066e-03  3.591435e-03
## C18.1.OH_T0       -9.234118e-04  2.672951e-04  3.648286e-03  7.110216e-04
## C18.2_T0          -9.846057e-04  1.299383e-03  4.224655e-03  1.619939e-03
## lysoPC.a.C16.0_T0  2.556280e-02  4.178108e-02  4.862934e-03 -3.086857e-02
## lysoPC.a.C16.1_T0  2.014913e-02  2.186324e-02 -1.372626e-02 -3.418675e-02
## lysoPC.a.C17.0_T0  7.783182e-03  1.614362e-02 -1.278502e-02  1.044028e-02
## lysoPC.a.C18.0_T0  1.542520e-02  6.500378e-02 -2.206736e-02 -1.473379e-02
## lysoPC.a.C18.1_T0  3.521016e-02  4.982641e-02 -1.942835e-02 -2.245310e-02
## lysoPC.a.C18.2_T0  6.329539e-02  1.096234e-01 -3.240428e-02  1.586087e-02
## lysoPC.a.C20.3_T0  7.304141e-03  5.034228e-02 -4.593012e-02 -1.618127e-02
## lysoPC.a.C20.4_T0  8.815317e-02  2.069575e-04 -5.929056e-02 -2.366674e-02
## lysoPC.a.C24.0_T0 -9.700802e-03 -2.515753e-04  6.442238e-03 -3.240191e-03
## lysoPC.a.C26.0_T0 -4.689553e-02 -4.899630e-02 -3.165835e-02 -3.326241e-02
## lysoPC.a.C26.1_T0 -2.677324e-03 -2.039666e-03  8.983271e-03 -4.889560e-04
## lysoPC.a.C28.0_T0  9.875283e-03 -7.104205e-02 -7.017408e-02  2.606919e-02
## lysoPC.a.C28.1_T0 -5.243889e-03 -2.717692e-03  5.266199e-03  1.870487e-03
## PC.aa.C24.0_T0    -7.941871e-03 -8.178057e-03  7.033402e-02 -6.905883e-02
## PC.aa.C28.1_T0     2.512899e-02 -9.880709e-03  1.873153e-02 -4.889612e-03
## PC.aa.C30.0_T0     1.721981e-02 -2.002867e-02  3.621551e-03 -3.439713e-02
## PC.aa.C32.0_T0     1.850971e-02 -4.740190e-02  3.483033e-02 -7.052074e-02
## PC.aa.C32.1_T0     3.907812e-02  3.132373e-03 -4.809612e-02 -9.936810e-02
## PC.aa.C32.3_T0    -5.184625e-04  1.085737e-03  3.190905e-03 -4.024116e-04
## PC.aa.C34.1_T0    -1.363685e-02 -3.028159e-02 -2.130208e-03 -1.680484e-02
## PC.aa.C34.2_T0    -3.320273e-03  3.713830e-02 -1.533421e-03  5.019943e-02
## PC.aa.C34.3_T0     2.317214e-02  8.875097e-02 -8.070000e-02 -3.359351e-02
## PC.aa.C34.4_T0     6.124671e-03  9.971465e-03 -1.868074e-02 -6.653369e-03
## PC.aa.C36.0_T0    -1.900783e-02 -2.767140e-03  2.527396e-03 -1.216610e-02
## PC.aa.C36.1_T0     1.534398e-03  3.569262e-02 -2.201023e-02 -4.302561e-02
## PC.aa.C36.2_T0    -1.390494e-02  4.634680e-02 -3.978655e-02  3.880724e-02
## PC.aa.C36.3_T0    -3.123463e-03  8.594698e-02 -4.409940e-02  1.856482e-02
## PC.aa.C36.4_T0     2.674258e-02 -6.466226e-03 -5.288930e-02 -4.058045e-04
## PC.aa.C36.5_T0     4.751567e-03  3.640604e-02 -5.697816e-02 -2.475218e-02
## PC.aa.C38.0_T0    -4.330025e-02 -1.812313e-02  7.844610e-03 -3.432196e-02
## PC.aa.C38.1_T0    -4.752403e-02  1.998789e-02 -8.566905e-03 -1.029621e-02
## PC.aa.C38.3_T0    -2.137518e-02  4.557289e-02 -6.459026e-02 -2.934414e-02
## PC.aa.C38.4_T0     2.779411e-02 -2.512343e-02 -6.799635e-02 -2.397106e-02
## PC.aa.C38.5_T0     7.165282e-02  2.167231e-02 -7.055039e-02 -3.329998e-02
## PC.aa.C38.6_T0    -1.089760e-01 -7.277295e-02  3.123919e-02  3.225996e-02
## PC.aa.C40.1_T0    -5.706020e-02 -9.645459e-02 -8.463728e-02 -6.083184e-02
## PC.aa.C40.2_T0    -1.710732e-02  9.889803e-03  2.285828e-02 -5.435965e-03
## PC.aa.C40.3_T0    -1.710833e-02  8.218577e-03  1.660331e-02 -7.656318e-03
## PC.aa.C40.4_T0     4.347806e-03  1.198486e-02 -6.272019e-03 -2.146941e-02
## PC.aa.C40.5_T0     9.927903e-03 -1.088410e-03 -5.284861e-02 -3.408879e-02
## PC.aa.C40.6_T0    -8.576444e-02 -7.974956e-02 -1.424585e-02 -3.170629e-02
## PC.aa.C42.0_T0    -3.252043e-03 -5.191612e-03  7.379707e-03 -1.437790e-02
## PC.aa.C42.1_T0    -4.188265e-03 -1.841826e-03  6.646036e-03 -5.765321e-03
## PC.aa.C42.2_T0    -8.124026e-03  4.533972e-03  8.917749e-03 -5.652817e-03
## PC.aa.C42.4_T0    -1.089395e-02  5.917717e-03  1.274648e-02 -3.840830e-03
## PC.aa.C42.5_T0    -9.068456e-03  2.469674e-03  7.481896e-03 -3.792296e-03
## PC.aa.C42.6_T0    -7.900507e-02 -4.354078e-02 -5.889573e-02 -1.643085e-02
## PC.ae.C30.0_T0     1.296718e-03 -1.583829e-03  3.771343e-03 -5.385731e-04
## PC.ae.C32.1_T0     9.087599e-03 -1.262309e-02  1.215224e-02 -1.656462e-02
## PC.ae.C32.2_T0    -6.082830e-04 -5.697287e-04  6.371665e-03 -3.986349e-03
## PC.ae.C34.0_T0    -1.439885e-03 -1.290965e-03 -5.602199e-04 -8.102079e-04
## PC.ae.C34.1_T0     8.660111e-03 -2.152220e-02 -8.517863e-04 -1.555633e-02
## PC.ae.C34.2_T0    -3.987401e-03  5.850034e-02 -7.183275e-02  5.369075e-03
## PC.ae.C34.3_T0     3.270389e-02  5.815911e-02 -8.012056e-03  5.204708e-03
## PC.ae.C36.0_T0    -8.505557e-03 -1.998137e-03  7.517168e-03 -4.731469e-03
## PC.ae.C36.1_T0    -2.543279e-02  1.143504e-02  2.383421e-02 -5.118934e-03
## PC.ae.C36.2_T0    -3.317209e-02  2.755614e-02 -1.645852e-02  3.154139e-02
## PC.ae.C36.3_T0    -1.022092e-02  3.885585e-02 -2.880692e-02  7.472467e-03
## PC.ae.C36.4_T0     2.426792e-02 -7.808073e-03 -7.944811e-02 -1.130506e-02
## PC.ae.C36.5_T0     2.510836e-02  4.868956e-03 -6.941803e-02 -2.607342e-02
## PC.ae.C38.0_T0    -1.584973e-02  6.806525e-03 -7.792178e-03 -6.403096e-03
## PC.ae.C38.2_T0    -5.016557e-02  2.832665e-02  3.698204e-02 -7.304292e-03
## PC.ae.C38.3_T0     2.355175e-02  9.053426e-03  2.041065e-02  1.272542e-02
## PC.ae.C38.4_T0     2.742137e-02 -2.199119e-02 -1.012060e-02 -1.183907e-03
## PC.ae.C38.5_T0     5.443913e-03 -2.157281e-02 -3.354511e-02 -3.664634e-03
## PC.ae.C38.6_T0    -6.755905e-03 -1.179576e-02 -4.846104e-02 -8.939368e-03
## PC.ae.C40.1_T0    -3.112303e-05  1.027990e-02  3.562830e-03 -1.729371e-02
## PC.ae.C40.2_T0    -2.764086e-02  1.129196e-02  3.144882e-02  6.466890e-03
## PC.ae.C40.3_T0     2.773855e-03  9.473914e-03  3.468408e-02  5.565826e-03
## PC.ae.C40.4_T0     7.771939e-03  7.038050e-04  2.626553e-02 -9.098433e-03
## PC.ae.C40.5_T0    -4.284959e-03  7.576031e-04  3.357796e-02 -1.500948e-03
## PC.ae.C40.6_T0    -1.219459e-02 -1.878090e-02 -2.897199e-03 -3.382792e-03
## PC.ae.C42.1_T0    -1.036169e-02  6.472336e-03  1.165624e-02 -4.964482e-03
## PC.ae.C42.2_T0    -8.377548e-03  7.293215e-03  1.168847e-02 -4.231508e-03
## PC.ae.C42.3_T0    -1.491342e-02  7.199068e-03  1.701073e-02 -6.867910e-03
## PC.ae.C42.4_T0     1.286503e-03  3.072302e-03  1.387848e-02 -1.257395e-02
## PC.ae.C42.5_T0     2.836173e-03 -1.582374e-02  2.359212e-02 -1.704043e-02
## PC.ae.C44.3_T0    -8.626726e-03  3.945037e-03  1.007617e-02 -2.418848e-03
## PC.ae.C44.4_T0    -1.995410e-03  1.134433e-03  4.567722e-03 -7.471991e-03
## PC.ae.C44.5_T0     1.701369e-02 -1.747354e-02 -3.501194e-03 -2.521859e-02
## PC.ae.C44.6_T0     8.644917e-03 -1.355020e-02 -9.016693e-04 -2.523803e-02
## SM..OH..C14.1_T0  -1.862868e-03 -6.541354e-03  4.368223e-03  2.973083e-02
## SM..OH..C16.1_T0  -8.638892e-03 -1.128518e-02  1.026700e-02  1.403261e-02
## SM..OH..C22.1_T0  -5.939349e-02 -3.541977e-02 -2.330311e-02  6.197891e-02
## SM..OH..C22.2_T0  -4.864624e-02  5.492834e-03  7.342730e-03  2.235689e-02
## SM..OH..C24.1_T0  -3.233136e-03 -1.623579e-03  3.172475e-03  7.312356e-03
## SM.C16.0_T0       -4.325044e-02 -6.421901e-02  8.763426e-02  1.641196e-02
## SM.C16.1_T0       -5.245865e-02  2.947474e-03  5.266606e-02  2.130010e-02
## SM.C18.0_T0       -6.308961e-02 -6.555852e-02  8.666762e-02  1.502255e-03
## SM.C18.1_T0       -5.418426e-02 -5.156286e-02  8.296813e-02  1.122693e-02
## SM.C20.2_T0       -2.023827e-03 -2.769167e-04  1.297574e-03 -7.727625e-04
## SM.C24.0_T0       -8.121286e-02 -3.239787e-02  1.824048e-02  2.058159e-02
## SM.C24.1_T0       -9.245548e-02 -5.964406e-02  6.424187e-02  1.212290e-02
## MEDDM_T2          -9.911653e-04  5.279635e-04  2.923889e-03  7.832266e-04
## MEDCOL_T2         -9.911653e-04  5.279635e-04  2.923889e-03  7.832266e-04
## MEDINF_T2          8.953846e-03 -1.650953e-03  6.330719e-03 -6.772204e-03
## MEDHTA_T2          2.593182e-02 -1.300926e-02 -4.772018e-03  4.026684e-03
## GLU_T2             1.648931e-02 -8.477003e-04  1.950746e-02 -3.770850e-03
## INS_T2             4.675348e-02  5.321836e-02  1.196790e-01  3.509012e-02
## HOMA_T2            2.344932e-02  2.522946e-02  7.343362e-02  1.442762e-02
## HBA1C_T2           1.941188e-02  1.798991e-02  1.225033e-02  7.925426e-03
## HBA1C.mmol.mol_T2  5.513343e-02  4.828663e-02  1.865908e-02  2.933667e-03
## PESO_T2           -1.862619e-02  6.391804e-02 -3.853431e-02  3.139737e-02
## bmi_T2            -1.355935e-03  4.972415e-02 -6.195746e-02  5.127104e-02
## CC_T2             -2.024593e-03  3.978531e-03  8.788991e-03 -2.754333e-04
## CINT_T2           -1.314651e-02  4.106960e-02  6.710103e-03 -1.144727e-03
## CAD_T2             2.637435e-02  2.665748e-02 -3.393187e-02  4.110680e-02
## TAD_T2             4.412112e-02 -5.541372e-02  7.881840e-02  6.562472e-02
## TAS_T2             1.865424e-02 -1.142595e-02  5.868610e-02  3.010707e-02
## TG_T2             -1.153820e-02 -8.979319e-03  2.028678e-02 -4.262034e-02
## COL_T2            -7.118528e-02 -5.750565e-02  1.910225e-02 -7.010333e-03
## LDL_T2            -4.042741e-02 -8.438368e-02  4.707772e-02  4.861225e-02
## HDL_T2             6.122039e-02 -5.605841e-02 -6.546252e-02 -6.684238e-02
## VLDL_T2            2.580204e-02 -5.590872e-02  1.035389e-02 -6.321582e-02
## PCR_T2            -1.392201e-02 -1.752635e-02 -2.959524e-02  6.015660e-02
## LEP_T2             1.445160e-01 -1.062939e-01 -9.307188e-02 -4.570599e-02
## ADIPO_T2          -6.813448e-02  2.299460e-02 -2.859411e-02 -1.615461e-02
## GOT_T2            -3.501413e-02 -5.997599e-02 -5.862521e-02 -1.236363e-01
## GPT_T2            -8.944025e-02 -4.007684e-02 -3.428534e-02 -7.958998e-02
## GGT_T2            -2.495619e-02  8.842103e-03  4.434617e-02 -5.037853e-02
## URICO_T2           6.160087e-02  3.683242e-02  5.654905e-02  1.024030e-02
## CREAT_T2           3.674025e-03  3.927328e-03  1.585899e-03  4.740251e-03
## UREA_T2           -3.197970e-02 -1.071864e-01  4.194784e-02  4.091856e-02
## HIERRO_T2         -8.365778e-02  2.588859e-02 -2.444644e-02  2.503881e-02
## TRANSF_T2          7.785915e-02 -6.306755e-02  3.694109e-02 -2.484630e-02
## FERR_T2            2.183598e-02  9.826416e-02 -7.859597e-03  5.483070e-02
## Ile_T2            -6.273345e-02 -1.868071e-02 -4.056459e-02  9.998340e-04
## Leu_T2            -1.997158e-02  1.656612e-02 -3.019838e-02  1.468440e-02
## Val_T2            -1.187340e-02  3.282317e-02 -1.890109e-02 -1.149232e-03
## Ala_T2             7.879184e-03  1.088893e-02 -7.198308e-02  1.313082e-02
## Pro_T2            -7.532557e-03  3.850072e-02 -8.450104e-02 -9.525547e-02
## Gly_T2            -2.433292e-02  2.625074e-03 -4.353830e-02  1.527929e-01
## Ser_T2            -3.126137e-02 -1.048416e-01 -6.180767e-02  1.301290e-01
## Trp_T2             2.335186e-02  5.660772e-02  6.739933e-02 -3.294382e-02
## Phe_T2            -2.847649e-02  2.443280e-02 -6.375444e-02  6.734116e-02
## Met_T2            -4.330558e-02  9.504658e-02  2.172273e-01 -8.193944e-02
## Orn_T2             1.545383e-02 -5.788844e-02 -5.925626e-02  5.763853e-02
## Arg_T2            -8.891368e-03 -1.923063e-02 -6.816146e-02  7.383555e-02
## His_T2             3.492720e-03  4.511903e-02 -1.896388e-02 -3.515106e-02
## Asn_T2            -4.206102e-02  1.079415e-03 -3.182359e-02 -6.703040e-02
## Asp_T2            -3.523461e-02  4.774158e-02 -9.843374e-02 -1.668647e-02
## Glu_T2             3.110277e-02 -8.787970e-03 -6.405101e-02  4.759389e-02
## Gln_T2            -6.721056e-02 -1.601074e-02 -5.372785e-02 -1.073045e-01
## Cit_T2            -3.934930e-03 -1.518388e-02 -1.478855e-02 -2.560720e-02
## Tyr_T2            -3.336147e-02 -1.149655e-02 -3.710853e-03 -5.850776e-02
## Thr_T2            -8.755445e-02  1.759466e-02  6.279467e-02  6.816541e-02
## Lys_T2             1.086899e-02 -3.429129e-02 -5.466171e-02  8.064243e-02
## Creatinine_T2      4.565924e-02  7.950216e-02 -2.342095e-02  5.287791e-02
## Kynurenine_T2     -3.876817e-03  2.256423e-03  1.487923e-02  1.266606e-02
## Putrescine_T2      1.789566e-02  1.064492e-01  2.711229e-04  2.141453e-02
## Sarcosine_T2      -3.949477e-02  1.069276e-01 -4.978811e-02  4.461097e-03
## Serotonin_T2      -6.193062e-02  4.545791e-03 -4.397605e-02  1.041369e-01
## Taurine_T2         5.835401e-02  1.595743e-02 -2.662333e-02 -4.287134e-02
## SDMA_T2           -6.719965e-03  7.138080e-03 -1.510335e-02  1.579310e-02
## C0_T2              4.990572e-02  6.824856e-03 -5.368667e-02  1.053199e-01
## C2_T2              2.626879e-02  7.378811e-02  3.790811e-02  1.200610e-01
## C3.OH_T2           1.900806e-05 -8.185863e-04  1.876807e-03  2.722125e-03
## C6..C4.1.DC._T2   -9.699887e-02  6.615711e-02 -8.976763e-03 -9.545094e-02
## C5.DC..C6.OH._T2   1.544145e-02  2.332764e-02 -3.952583e-02  1.311442e-02
## C7.DC_T2          -1.768305e-02  5.818780e-02 -6.453658e-02 -3.963598e-03
## C8_T2             -2.412043e-05  7.252282e-03  1.684626e-03  7.247103e-03
## C10_T2             9.098022e-04  9.002288e-03  3.789834e-03  1.232534e-02
## C10.1_T2          -1.646129e-03  1.842566e-03  2.288822e-03  3.456666e-03
## C10.2_T2          -7.716303e-04  3.742090e-05  3.040271e-03  6.499677e-04
## C14.1_T2          -6.832956e-04  5.790824e-03  4.320679e-03  5.876488e-03
## C14.2_T2          -1.346614e-03  2.573006e-03  2.508106e-03  3.918485e-03
## C16.1_T2          -1.456296e-03  2.445837e-03  2.187982e-03  2.307675e-03
## C16.2_T2          -1.333018e-03  1.218888e-03  2.413656e-03  1.584779e-03
## C16.2.OH_T2       -1.136716e-03  1.335409e-03  2.778955e-03  1.098748e-03
## C18.1_T2          -2.087711e-03  1.974950e-03  2.711001e-03  6.386003e-03
## C18.1.OH_T2       -1.139894e-03  1.153167e-03  3.147127e-03  1.240323e-03
## C18.2_T2          -2.337988e-03  3.140107e-03  3.062750e-03  4.513659e-03
## lysoPC.a.C14.0_T2 -1.290242e-02  2.311099e-02  7.247146e-02  6.462281e-02
## lysoPC.a.C16.0_T2 -3.373182e-03 -4.176391e-02 -1.167032e-02 -5.369710e-02
## lysoPC.a.C16.1_T2  2.093264e-02 -1.537314e-02  1.512132e-02 -3.985207e-02
## lysoPC.a.C17.0_T2  8.861219e-03 -1.214418e-02 -7.731017e-03 -9.642615e-04
## lysoPC.a.C18.0_T2  2.466081e-02 -4.193506e-02  9.119549e-03 -6.317242e-02
## lysoPC.a.C18.1_T2  6.525411e-02 -2.307826e-02  4.128789e-02 -4.989409e-02
## lysoPC.a.C18.2_T2  4.037329e-02 -4.363632e-02 -1.643024e-02 -9.078565e-02
## lysoPC.a.C20.3_T2  2.406327e-02  9.949472e-03  2.719932e-02 -1.898636e-02
## lysoPC.a.C20.4_T2  5.418730e-02 -5.300595e-02 -3.978769e-02 -6.029016e-02
## lysoPC.a.C24.0_T2 -2.263129e-03 -2.476125e-03 -7.596989e-03  5.339777e-03
## lysoPC.a.C26.0_T2 -4.201151e-02  3.090640e-02  6.476857e-02 -4.017543e-03
## lysoPC.a.C26.1_T2 -5.733265e-03 -1.140023e-03 -1.048346e-02  9.056414e-03
## lysoPC.a.C28.0_T2 -1.965011e-02 -7.322814e-02 -1.059041e-01 -1.391190e-02
## lysoPC.a.C28.1_T2 -2.487253e-03 -7.862979e-03 -2.094905e-02  1.282482e-02
## PC.aa.C24.0_T2    -7.619948e-02 -8.510572e-02 -6.746034e-02  5.207658e-02
## PC.aa.C28.1_T2    -7.522110e-04  5.902900e-03  9.915304e-03 -5.552527e-03
## PC.aa.C30.0_T2    -9.170630e-04  2.550480e-03  2.206746e-02 -6.476651e-03
## PC.aa.C32.0_T2    -7.837872e-03 -2.817911e-02  3.364653e-02  1.713642e-03
## PC.aa.C32.1_T2     4.655480e-02 -1.852516e-02  4.605838e-02 -1.089279e-01
## PC.aa.C32.3_T2    -1.039996e-03 -1.035697e-03  1.295425e-03  2.255788e-03
## PC.aa.C34.1_T2    -5.612380e-03  1.170510e-02  6.233425e-02  1.566495e-02
## PC.aa.C34.2_T2    -4.958195e-02  3.204665e-02  1.968838e-02 -2.717822e-02
## PC.aa.C34.3_T2     1.211790e-02  1.672660e-02  2.866664e-02 -5.746633e-02
## PC.aa.C34.4_T2     1.068949e-03  2.834393e-05  6.423944e-03 -6.812104e-03
## PC.aa.C36.0_T2    -1.046101e-03 -2.386681e-02 -3.644379e-02  7.040659e-03
## PC.aa.C36.1_T2     3.420778e-02  3.131029e-02  4.040003e-02 -2.274348e-02
## PC.aa.C36.2_T2     4.809134e-03  3.027541e-02  2.200022e-02 -5.029402e-02
## PC.aa.C36.3_T2     3.803844e-04  7.412622e-02  5.902022e-02 -2.014688e-02
## PC.aa.C36.4_T2    -2.893374e-03  3.393603e-03  1.594108e-02 -4.024144e-02
## PC.aa.C36.5_T2    -3.055038e-02  3.955556e-02  2.605335e-02 -7.736875e-02
## PC.aa.C38.0_T2    -2.082187e-03 -1.132232e-02 -6.934888e-03 -2.454134e-04
## PC.aa.C38.1_T2    -2.979076e-04 -4.261484e-02 -2.249659e-02 -5.492872e-02
## PC.aa.C38.3_T2     2.339337e-02  6.422720e-02  5.100430e-02  1.336287e-03
## PC.aa.C38.4_T2     1.016358e-02  6.017015e-03  3.244952e-02 -3.066981e-02
## PC.aa.C38.5_T2     3.269357e-02  4.001305e-02  7.216809e-02 -1.245234e-02
## PC.aa.C38.6_T2    -8.760519e-02  1.825248e-03  3.169386e-02  3.297879e-02
## PC.aa.C40.1_T2    -5.307732e-02  6.411882e-03 -7.720692e-02 -4.684757e-03
## PC.aa.C40.2_T2     1.158437e-02 -2.683461e-02 -5.094810e-02  2.816061e-02
## PC.aa.C40.3_T2     1.475254e-03 -1.924734e-02 -4.121777e-02  2.472294e-02
## PC.aa.C40.4_T2     1.102322e-02  1.291791e-03 -6.473533e-03  2.344694e-02
## PC.aa.C40.5_T2     1.902375e-02  1.717305e-02  3.592169e-02  9.882339e-03
## PC.aa.C40.6_T2    -4.100870e-02 -4.944293e-03  1.947667e-02 -1.188588e-02
## PC.aa.C42.0_T2    -1.579538e-03 -6.408509e-03 -1.117576e-02  1.870584e-03
## PC.aa.C42.1_T2    -1.011722e-03 -7.428280e-03 -1.043462e-02  5.213001e-03
## PC.aa.C42.2_T2    -5.006902e-03 -7.661909e-03 -1.544219e-02  7.878895e-03
## PC.aa.C42.4_T2     8.230681e-04 -5.648232e-03 -7.991772e-03  9.493368e-03
## PC.aa.C42.5_T2    -7.062597e-04 -3.432880e-03 -3.363849e-03  3.402878e-03
## PC.aa.C42.6_T2     4.180381e-02  5.380262e-02 -2.494620e-02 -4.220958e-02
## PC.ae.C30.0_T2     9.857296e-03 -2.142449e-02  4.635733e-02 -3.694638e-02
## PC.ae.C32.1_T2     1.056437e-02 -5.112871e-03  5.929425e-03 -2.678552e-02
## PC.ae.C32.2_T2     7.525500e-04 -3.487802e-03 -1.412438e-03 -1.984904e-04
## PC.ae.C34.0_T2     2.511828e-03 -1.256412e-03  1.643247e-03  1.725880e-04
## PC.ae.C34.1_T2     2.151178e-02  4.098190e-03  1.625254e-02  1.551675e-04
## PC.ae.C34.2_T2     2.247647e-02  2.699204e-02  1.797107e-02 -1.969179e-02
## PC.ae.C34.3_T2     1.057634e-02  2.191938e-02  7.978442e-03 -2.924764e-02
## PC.ae.C36.0_T2    -1.929937e-03 -7.905445e-03  2.060631e-03  2.000558e-03
## PC.ae.C36.1_T2     2.649298e-02 -7.847719e-02 -1.421712e-01  8.844985e-02
## PC.ae.C36.2_T2     3.689088e-03 -6.733470e-03 -4.224726e-02  3.415376e-02
## PC.ae.C36.3_T2     8.756143e-03  2.741273e-02  1.999911e-02 -1.406624e-02
## PC.ae.C36.4_T2     2.511441e-02  2.253640e-02  2.319460e-02 -4.572623e-02
## PC.ae.C36.5_T2     1.207346e-02  1.108545e-02  1.241656e-02 -6.442925e-02
## PC.ae.C38.0_T2    -6.143848e-03  8.566650e-04  1.158745e-02 -6.102618e-03
## PC.ae.C38.2_T2     1.679473e-02 -5.016050e-02 -9.801692e-02  6.129040e-02
## PC.ae.C38.3_T2     1.628826e-02 -4.505650e-02 -9.261536e-02  6.930505e-02
## PC.ae.C38.4_T2     3.060318e-02  1.147827e-02 -9.815141e-03 -8.952688e-03
## PC.ae.C38.5_T2     1.829871e-02  1.877486e-02  3.418726e-02 -2.928527e-02
## PC.ae.C38.6_T2    -2.568127e-03  1.006919e-02  1.301371e-02 -1.951128e-02
## PC.ae.C40.1_T2     2.920801e-03 -2.859503e-02 -4.416215e-02  1.693979e-02
## PC.ae.C40.2_T2     5.104808e-03 -2.067963e-02 -4.460841e-02  2.230650e-02
## PC.ae.C40.3_T2     1.478070e-02 -4.020752e-02 -7.947540e-02  5.722529e-02
## PC.ae.C40.4_T2     1.167521e-02 -1.922302e-02 -4.386429e-02  2.462032e-02
## PC.ae.C40.5_T2    -9.635409e-03 -1.845568e-03 -1.231624e-02  3.086145e-02
## PC.ae.C40.6_T2    -5.015901e-03  6.984081e-03  5.088424e-03  4.368430e-03
## PC.ae.C42.1_T2     5.750852e-03 -1.818105e-02 -3.227890e-02  1.963234e-02
## PC.ae.C42.2_T2     2.189558e-03 -1.426261e-02 -3.027909e-02  1.618346e-02
## PC.ae.C42.3_T2    -3.256397e-03 -1.141929e-02 -2.641010e-02  1.493025e-02
## PC.ae.C42.4_T2    -5.150273e-04  2.767487e-03 -1.386642e-02  4.704500e-03
## PC.ae.C42.5_T2     1.176983e-02  6.246561e-03  1.914015e-03 -3.892522e-03
## PC.ae.C44.3_T2    -1.715944e-02  1.112528e-02 -4.336781e-02 -8.376182e-03
## PC.ae.C44.4_T2     1.205511e-03 -1.017853e-03 -5.176044e-03  3.624032e-03
## PC.ae.C44.5_T2     1.296075e-02  2.601980e-02 -1.662745e-03 -1.120594e-02
## PC.ae.C44.6_T2     5.213568e-03  7.944752e-03 -2.879640e-03 -1.387815e-02
## SM..OH..C14.1_T2  -6.504266e-05  1.642401e-02 -2.284534e-02  2.180980e-02
## SM..OH..C16.1_T2  -9.184391e-03  6.326241e-03 -1.629110e-02  1.085252e-02
## SM..OH..C22.1_T2  -1.307015e-05  3.550178e-02 -2.815050e-04 -6.589501e-03
## SM..OH..C22.2_T2   7.592869e-03  3.482566e-02 -4.189834e-02  3.290540e-02
## SM..OH..C24.1_T2  -3.100937e-03  6.481472e-03  2.422095e-03  5.342837e-04
## SM.C16.0_T2       -2.083033e-02  5.175418e-02 -2.046697e-02  1.864689e-02
## SM.C16.1_T2       -2.910929e-02  1.867744e-02  5.097994e-03  2.096646e-02
## SM.C18.0_T2       -8.409755e-02  3.386352e-02 -5.466597e-02  1.805527e-02
## SM.C18.1_T2       -3.513079e-02  1.325355e-02 -4.367383e-02  3.792925e-02
## SM.C20.2_T2       -2.369519e-03  3.248041e-03  1.716455e-03  7.287069e-04
## SM.C24.0_T2       -1.705611e-02  4.081277e-02 -2.995803e-03 -9.755392e-04
## SM.C24.1_T2       -4.878942e-02  9.746449e-02 -1.800363e-02  4.525373e-02
## MEDDM_T4           9.375667e-03 -4.715606e-03 -2.700106e-03  1.185366e-03
## MEDCOL_T4         -2.905991e-03  5.713674e-03  1.121273e-03  2.368012e-03
## MEDINF_T4          3.184360e-03 -1.160451e-03  4.095999e-03  2.811296e-03
## MEDHTA_T4          5.575104e-03 -3.126832e-03 -5.776509e-03  1.338355e-03
## GLU_T4             1.531282e-02 -7.437063e-02 -4.972259e-02 -1.841961e-02
## INS_T4             9.701305e-02 -6.705788e-02  2.364217e-02 -6.026444e-02
## HOMA_T4            2.767984e-02 -3.037831e-02  9.135631e-03 -2.986632e-02
## HBA1C_T4           4.805742e-03  1.298056e-02  1.539079e-03  2.262702e-02
## HBA1C.mmol.mol_T4 -1.919091e-03  2.461866e-02 -2.060330e-02  5.200551e-02
## PESO_T4           -1.237741e-02  5.213147e-02 -4.464756e-02  1.723046e-02
## bmi_T4             5.941836e-03  3.496368e-02 -7.038966e-02  3.919279e-02
## CC_T4              3.398367e-05  8.538546e-03 -7.051784e-05  2.776486e-05
## CINT_T4            1.038574e-03  5.766510e-02 -5.141747e-03  3.183460e-02
## CAD_T4             3.688257e-02 -1.049550e-02 -1.001525e-03  4.556738e-02
## TAD_T4             1.859987e-02 -3.115785e-02  2.428072e-02  4.360761e-02
## TAS_T4             2.059857e-02  7.207492e-03  1.521389e-02  3.137333e-02
## TG_T4              9.851057e-03 -1.807109e-02 -2.098855e-02 -2.835984e-02
## COL_T4            -4.023795e-02 -4.036589e-02  2.031726e-02  2.183079e-02
## LDL_T4            -1.336198e-02 -5.116587e-02  4.803542e-02  5.035156e-02
## HDL_T4             1.536171e-02 -3.914597e-02 -2.076336e-02  1.032260e-02
## VLDL_T4            4.506481e-02 -5.336568e-02 -4.231559e-02 -2.404274e-02
## PCR_T4            -8.730175e-02 -6.820554e-02 -6.628358e-02  4.278771e-04
## LEP_T4            -1.195295e-02 -6.094294e-02 -1.351342e-01 -5.621609e-02
## ADIPO_T4          -9.497587e-02  1.759113e-02 -3.835188e-02 -2.122840e-02
## GOT_T4            -1.716073e-02 -1.093425e-01  1.622295e-02 -6.203767e-02
## GPT_T4            -7.926390e-02 -1.209965e-01 -1.514575e-02 -7.208136e-02
## GGT_T4            -6.103930e-02 -2.918049e-02  4.003520e-02 -1.071619e-01
## URICO_T4           4.641773e-02  1.350547e-02 -3.514068e-03 -4.446251e-02
## CREAT_T4           1.528890e-03 -5.255960e-03  4.627117e-03 -1.364635e-03
## UREA_T4           -1.318951e-02 -9.664817e-02  2.661167e-02  3.694428e-02
## HIERRO_T4          1.345436e-01  1.672480e-03 -6.313214e-02  1.069178e-01
## TRANSF_T4          8.403574e-02 -3.307887e-02  1.256826e-02 -8.202724e-03
## FERR_T4           -1.483132e-02  6.496308e-02 -2.263683e-02 -1.464655e-02
## Ile_T4            -1.584069e-02  1.182269e-02  2.545157e-02 -3.545495e-02
## Leu_T4             9.827905e-03  3.605711e-02  4.905854e-02 -1.570006e-02
## Val_T4             2.362936e-02  4.986030e-02 -4.803926e-03  5.006326e-03
## Ala_T4             4.202115e-02 -2.898063e-02 -3.351849e-02  8.394300e-04
## Pro_T4             5.673297e-02  8.061497e-02 -1.011808e-01 -8.311945e-02
## Gly_T4             2.134783e-02 -6.508990e-03 -5.637388e-03  5.533592e-02
## Ser_T4            -3.719768e-02 -3.256816e-02  1.046736e-01  7.916213e-02
## Trp_T4             8.627060e-02  1.301158e-03  3.169436e-02  3.567947e-02
## Phe_T4            -2.653100e-02  3.317093e-02  2.703264e-02 -3.995161e-02
## Met_T4            -1.178148e-01 -1.307719e-03 -2.532248e-02 -5.443656e-02
## Orn_T4             3.396041e-02 -2.406326e-02 -1.167396e-02 -9.885195e-04
## Arg_T4             4.404821e-02  5.443284e-03 -2.207176e-02  2.038828e-02
## His_T4             4.727921e-03  6.799257e-02 -6.592408e-03  6.372457e-03
## Asn_T4             2.297180e-02 -2.867287e-02  5.032455e-03 -3.727870e-02
## Asp_T4             4.320115e-02 -3.607691e-02  6.753731e-02 -3.056107e-02
## Glu_T4             6.168194e-02  8.999204e-03  9.338409e-02  1.426145e-02
## Gln_T4            -4.406654e-02 -5.482482e-02  7.896679e-02  2.929557e-02
## Cit_T4            -1.722345e-02 -3.349623e-02 -5.517251e-02  4.457848e-02
## Tyr_T4             9.124156e-03 -4.981697e-03 -6.882342e-02 -6.003172e-02
## Thr_T4             1.092593e-01 -5.769026e-02 -3.930174e-03  5.964011e-03
## Lys_T4             2.158478e-02 -9.238020e-02  1.147208e-01  4.054135e-02
## Creatinine_T4      9.161301e-02 -2.103046e-02  1.432104e-02  2.878718e-05
## Kynurenine_T4      9.065129e-02 -5.703054e-02  7.016001e-02  2.555024e-02
## Putrescine_T4     -1.598576e-02  4.899005e-02 -1.206852e-02  1.012728e-01
## Sarcosine_T4       5.513152e-02  6.123845e-02 -3.151420e-02 -6.165565e-02
## Serotonin_T4      -6.784092e-02  2.221400e-02 -3.324008e-02  9.927074e-02
## Taurine_T4        -4.555942e-02 -9.764327e-02  6.540877e-02 -2.940683e-02
## SDMA_T4            8.995936e-03  2.236678e-03 -1.724019e-03  3.232206e-03
## C0_T4              1.490256e-02  2.649854e-02 -5.917645e-02  3.499645e-02
## C2_T4              6.756532e-02  1.261699e-02  1.321794e-02  2.308569e-02
## C3.OH_T4           3.838651e-04  3.104994e-03  2.495082e-03  3.443113e-03
## C6..C4.1.DC._T4    4.082851e-02  6.612392e-02  7.651801e-02 -4.155221e-02
## C5.DC..C6.OH._T4   7.181940e-02 -1.250130e-02  7.342475e-03  5.700975e-02
## C7.DC_T4           3.494437e-02 -3.299639e-02  7.039747e-04  2.537542e-02
## C8_T4              1.300244e-03  7.865992e-03  2.040908e-03  5.163441e-03
## C10_T4            -1.521317e-03  7.500242e-03  1.862983e-03  3.318611e-03
## C10.1_T4           3.384993e-04  2.750351e-03  1.193753e-03  6.287707e-04
## C10.2_T4           1.161433e-03  9.993309e-04  3.944564e-03 -1.074417e-04
## C14.1_T4           2.709125e-03  1.728858e-03  3.996609e-03  2.326651e-03
## C14.2_T4           6.919060e-04 -9.752861e-05  4.849237e-03  2.649213e-03
## C16.1_T4           1.879098e-02 -1.048728e-02 -1.025397e-02  3.751389e-02
## C16.2_T4           8.195999e-05  9.420312e-04  3.574284e-03  9.823322e-04
## C16.2.OH_T4        1.750015e-02 -1.067913e-02 -1.067683e-02  3.694400e-02
## C18.1_T4           3.643137e-04 -7.939965e-04  3.731587e-03  9.539115e-04
## C18.1.OH_T4       -5.075112e-04  1.044260e-03  2.921219e-03  1.065857e-03
## C18.2_T4           1.854538e-04  7.450239e-04  3.789210e-03  6.083981e-04
## lysoPC.a.C16.0_T4  8.411185e-02  2.444081e-02  3.253363e-02 -6.602494e-03
## lysoPC.a.C16.1_T4  5.626986e-03  1.013164e-02 -9.507944e-03 -3.903546e-02
## lysoPC.a.C17.0_T4  2.382299e-02  9.234446e-03 -2.246153e-03  1.796287e-02
## lysoPC.a.C18.0_T4  7.514289e-02  3.065902e-02  4.205850e-02  3.422429e-02
## lysoPC.a.C18.1_T4  3.638672e-02 -3.418943e-03 -8.331861e-03 -1.760473e-02
## lysoPC.a.C18.2_T4  3.153534e-02  7.739094e-03 -2.433305e-02 -4.873898e-02
## lysoPC.a.C20.3_T4 -1.034663e-05  1.946724e-02 -1.294383e-02 -3.139607e-02
## lysoPC.a.C20.4_T4  1.053791e-01 -3.844102e-02 -3.133316e-02 -6.346333e-02
## lysoPC.a.C24.0_T4  1.384890e-03  2.447628e-05  9.207406e-03  5.225380e-03
## lysoPC.a.C26.0_T4  3.073576e-02 -4.883490e-02  4.100989e-02  3.154628e-02
## lysoPC.a.C26.1_T4  3.544097e-03  1.874351e-03  8.646300e-03  5.656429e-03
## lysoPC.a.C28.0_T4 -5.568138e-02 -8.477421e-02  9.116639e-02  9.249561e-02
## lysoPC.a.C28.1_T4  9.064796e-03  1.158993e-03  6.704579e-03  7.530077e-03
## PC.aa.C24.0_T4     6.303839e-02  9.310462e-03  6.984261e-02 -7.674350e-03
## PC.aa.C28.1_T4     2.325534e-02 -7.587546e-03  1.823628e-02  1.391811e-02
## PC.aa.C30.0_T4    -6.889432e-04 -1.555062e-02  1.238168e-02 -8.163480e-03
## PC.aa.C32.0_T4     8.410499e-03 -1.451199e-02  1.144552e-02 -3.574214e-02
## PC.aa.C32.1_T4    -4.154297e-02  1.006364e-02 -3.246710e-02 -5.969915e-02
## PC.aa.C32.3_T4    -4.673074e-04  1.543659e-03  2.561619e-03  1.514657e-03
## PC.aa.C34.1_T4    -1.962152e-02 -3.592362e-03  1.071038e-02  1.392639e-04
## PC.aa.C34.2_T4    -2.320414e-02  4.550460e-02 -2.154261e-03  1.138052e-02
## PC.aa.C34.3_T4    -5.791237e-02  6.268274e-02 -6.266998e-02 -1.047678e-02
## PC.aa.C34.4_T4    -3.816432e-03  3.444104e-03 -3.857447e-03 -1.795302e-04
## PC.aa.C36.0_T4    -7.420024e-03  6.618358e-03 -1.326989e-03  1.028064e-02
## PC.aa.C36.1_T4    -3.998255e-02 -1.501742e-02  6.065667e-02  3.111147e-02
## PC.aa.C36.2_T4    -3.469857e-02  1.328543e-02  8.209447e-03  3.247730e-02
## PC.aa.C36.3_T4    -5.293483e-02  6.177476e-02  5.790445e-03 -1.059155e-02
## PC.aa.C36.4_T4     2.095114e-02 -4.052000e-03 -7.465802e-03 -3.795882e-02
## PC.aa.C36.5_T4    -5.078897e-02  3.036902e-02 -6.545073e-02  2.855971e-02
## PC.aa.C38.0_T4    -2.965355e-02 -8.691793e-03  6.667009e-03  1.148638e-02
## PC.aa.C38.1_T4     9.438477e-03  1.476308e-02  3.357674e-03  1.721104e-02
## PC.aa.C38.3_T4    -5.505681e-02  4.007609e-02  6.975127e-03 -7.552169e-02
## PC.aa.C38.4_T4    -8.876724e-03 -2.166112e-02 -1.535632e-02 -4.785513e-02
## PC.aa.C38.5_T4     9.925727e-03 -8.110210e-03 -1.957103e-02 -9.000037e-03
## PC.aa.C38.6_T4    -8.614923e-02  1.190750e-02 -2.800232e-02  7.542684e-02
## PC.aa.C40.1_T4     5.902004e-02 -5.533734e-02  8.892759e-02 -8.880476e-02
## PC.aa.C40.2_T4     1.109472e-02  4.519020e-03  2.188598e-02  9.198743e-03
## PC.aa.C40.3_T4     5.289911e-03  3.513017e-03  1.779659e-02  3.758991e-03
## PC.aa.C40.4_T4     8.021023e-03  3.640565e-03  3.390468e-02 -7.746156e-03
## PC.aa.C40.5_T4    -9.181247e-03 -5.614183e-03  1.789618e-02 -2.571620e-02
## PC.aa.C40.6_T4    -1.286915e-01 -1.894850e-02 -2.607117e-02  6.726414e-02
## PC.aa.C42.0_T4     6.478901e-03 -1.366334e-04  4.241212e-03 -5.958891e-03
## PC.aa.C42.1_T4     1.220505e-03  1.743250e-03  5.611076e-03  1.033000e-03
## PC.aa.C42.2_T4    -5.171334e-03  3.157764e-03  9.734613e-03  4.090590e-03
## PC.aa.C42.4_T4    -3.239655e-03  3.288130e-03  1.226676e-02  4.975388e-03
## PC.aa.C42.5_T4    -1.380341e-03  2.601796e-03  5.253784e-03  2.275272e-03
## PC.aa.C42.6_T4     4.521876e-02 -9.247101e-02  7.104816e-02  5.244620e-03
## PC.ae.C30.0_T4    -1.237983e-02 -6.493066e-02  3.785597e-02  3.199201e-02
## PC.ae.C32.1_T4     1.871629e-02 -1.346502e-02  2.451525e-03 -1.472791e-02
## PC.ae.C32.2_T4    -9.893207e-04  3.817871e-03  3.981198e-04  2.023999e-03
## PC.ae.C34.0_T4     9.590224e-04 -2.655974e-03  1.159839e-03 -8.383511e-04
## PC.ae.C34.1_T4     5.330578e-03 -2.163956e-02 -2.842625e-03 -1.000097e-02
## PC.ae.C34.2_T4     1.730273e-02  2.649407e-02 -1.963397e-02 -4.599712e-03
## PC.ae.C34.3_T4     1.299543e-02  5.122898e-02 -1.032637e-02  1.363244e-03
## PC.ae.C36.0_T4    -2.730378e-03 -2.564113e-03  8.105480e-03  2.957311e-03
## PC.ae.C36.1_T4    -4.860999e-02  2.311193e-02  5.425870e-02  2.942109e-02
## PC.ae.C36.2_T4     5.703749e-03  3.256920e-02 -1.312221e-02  5.230160e-02
## PC.ae.C36.3_T4    -7.020505e-03  1.637412e-02  6.033171e-03 -3.454729e-03
## PC.ae.C36.4_T4     2.997787e-02 -5.461901e-04  1.087326e-02 -4.245943e-02
## PC.ae.C36.5_T4     8.332583e-03  5.412611e-03 -3.152128e-02 -1.715636e-02
## PC.ae.C38.0_T4    -2.460732e-02  8.462289e-03 -1.034089e-02  1.645968e-02
## PC.ae.C38.2_T4    -8.157852e-03  1.283343e-02  4.899620e-02  3.231701e-02
## PC.ae.C38.3_T4     3.526950e-02  1.723112e-02  4.566952e-02  3.332654e-02
## PC.ae.C38.4_T4     4.638408e-02 -2.148264e-02  1.346489e-02 -1.157717e-02
## PC.ae.C38.5_T4     3.489666e-02 -2.110927e-02  1.518068e-02 -2.930928e-02
## PC.ae.C38.6_T4    -1.151427e-02  7.437395e-03 -1.196848e-02  1.100663e-02
## PC.ae.C40.1_T4     7.223748e-03  7.197248e-04  1.197322e-02  1.420845e-02
## PC.ae.C40.2_T4     7.206387e-03  2.505834e-04  1.681976e-02  1.223638e-02
## PC.ae.C40.3_T4     2.816495e-02  5.975287e-03  4.076077e-02  2.781941e-02
## PC.ae.C40.4_T4     3.175338e-02 -6.604172e-03  3.606933e-02  5.960865e-03
## PC.ae.C40.5_T4    -1.076078e-02  6.601024e-03  5.699620e-02  1.010308e-02
## PC.ae.C40.6_T4    -1.118982e-02  1.986514e-04  2.618872e-03  1.444210e-02
## PC.ae.C42.1_T4     4.725414e-03  4.159007e-03  9.864597e-03  8.464361e-03
## PC.ae.C42.2_T4     6.285191e-03  9.543061e-04  8.446800e-03  4.647624e-03
## PC.ae.C42.3_T4    -6.116317e-03  7.419067e-03  1.585936e-02  6.189339e-03
## PC.ae.C42.4_T4     1.563540e-02  8.618701e-06  1.628043e-02  1.473037e-03
## PC.ae.C42.5_T4     1.276672e-02 -3.592395e-03  2.371201e-02 -2.540933e-02
## PC.ae.C44.3_T4    -3.480361e-03  1.984622e-03  7.966998e-03  1.807225e-03
## PC.ae.C44.4_T4     3.413962e-03  1.610075e-03  4.345039e-03 -3.133981e-03
## PC.ae.C44.5_T4     4.503514e-02 -8.292321e-03  4.824990e-03 -3.094764e-02
## PC.ae.C44.6_T4     2.741137e-02 -1.969836e-03  6.692098e-03 -2.004821e-02
## SM..OH..C14.1_T4   2.440396e-02  9.285132e-03 -1.250743e-02  2.643307e-02
## SM..OH..C16.1_T4  -4.872765e-03 -2.321801e-03 -7.461149e-03  1.069332e-02
## SM..OH..C22.1_T4   1.650875e-02  1.332188e-02  1.841842e-02  5.943881e-02
## SM..OH..C22.2_T4   3.230161e-02  4.260669e-02 -1.998289e-03  4.305373e-02
## SM..OH..C24.1_T4   1.353230e-04  3.638098e-03  3.688542e-03  5.231323e-03
## SM.C16.0_T4        1.833635e-02  2.438541e-03  2.775730e-02  2.614842e-02
## SM.C16.1_T4        1.696420e-02  3.968417e-02  1.238405e-02  3.986600e-02
## SM.C18.0_T4       -2.520796e-02 -2.259156e-02  3.757762e-03 -2.285185e-02
## SM.C18.1_T4       -8.758456e-03  1.190193e-02 -1.444105e-02  1.218703e-02
## SM.C20.2_T4       -1.672315e-03  2.041671e-03  1.356264e-03 -9.266718e-04
## SM.C24.0_T4       -1.001864e-02 -8.351687e-03  8.862881e-02  4.554744e-02
## SM.C24.1_T4        5.891252e-04  4.626708e-02  7.878966e-03 -1.103599e-02
## MEDDM_T5          -1.492733e-02  8.154353e-03  9.101135e-03  1.048376e-03
## MEDCOL_T5         -1.492733e-02  8.154353e-03  9.101135e-03  1.048376e-03
## MEDINF_T5         -1.081073e-02  5.106787e-03  6.656784e-03  3.726885e-03
## MEDHTA_T5         -4.214855e-03  2.734542e-03  3.296751e-03  1.463147e-03
## GLU_T5             8.043309e-02 -1.207994e-02 -1.671121e-02 -1.665350e-02
## INS_T5             7.301582e-02 -1.098654e-02 -8.712424e-03 -4.298040e-02
## HOMA_T5            2.931704e-02 -6.754483e-03 -5.668148e-03 -2.047715e-02
## HBA1C_T5           1.223229e-02  1.717109e-02  8.631266e-03  1.164594e-02
## HBA1C.mmol.mol_T5  2.350175e-02  3.924956e-02  3.340921e-03  1.478818e-02
## PESO_T5            3.673310e-02  2.014526e-02 -1.386006e-02  4.964842e-03
## bmi_T5             4.696449e-02  2.280369e-02 -3.993394e-03  2.449037e-02
## CC_T5             -1.979421e-03  1.165159e-03  5.220987e-03  4.017664e-03
## CINT_T5            3.942444e-02  1.349129e-03 -1.004816e-02  2.141498e-02
## CAD_T5             1.097828e-01  2.031511e-02 -6.425707e-03  1.139558e-02
## TAD_T5             1.005277e-02 -2.492230e-02  5.989210e-02  3.025281e-02
## TAS_T5             1.335740e-02  2.338894e-02 -1.545072e-02  3.365492e-02
## TG_T5              2.180793e-02  7.056522e-02  1.578080e-02  3.630547e-02
## COL_T5             2.047714e-02  9.748486e-03  5.047338e-02 -2.760246e-02
## LDL_T5             1.644639e-02  8.970165e-03  6.297824e-02 -1.178856e-02
## HDL_T5             6.761987e-02 -2.888907e-02  4.568486e-02 -6.432973e-02
## VLDL_T5            6.703063e-02  9.645210e-03  2.071417e-03  1.662894e-02
## PCR_T5            -5.144323e-03 -3.194223e-02 -2.855846e-02  1.554260e-02
## LEP_T5             2.511148e-02 -2.664271e-02 -1.180057e-01 -7.336785e-02
## ADIPO_T5          -5.975505e-02  3.593471e-02  4.398430e-02 -4.003941e-02
## GOT_T5             4.818860e-02 -1.026677e-01 -3.642833e-03  2.256528e-03
## GPT_T5             7.307368e-03 -5.210322e-02 -2.632477e-02 -4.476496e-03
## GGT_T5             5.489090e-02 -5.308075e-02  1.516896e-02  1.370718e-02
## URICO_T5           6.969940e-02  1.425892e-02 -1.182312e-02 -1.580250e-03
## CREAT_T5           2.836846e-03 -4.840654e-04 -1.167632e-04  2.655480e-03
## UREA_T5           -8.324976e-02 -4.535956e-02 -1.324840e-02  9.828564e-02
## HIERRO_T5         -1.118394e-02  7.903840e-02  5.634485e-02  2.086069e-02
## TRANSF_T5          1.326972e-01 -3.004051e-02 -1.969505e-02  6.625238e-03
## FERR_T5           -5.795884e-02  5.506407e-03 -4.303407e-02 -2.419635e-02
## Ile_T5            -2.462488e-02  6.809796e-02  2.663435e-02  1.705043e-02
## Leu_T5            -3.820974e-02  1.037080e-01 -4.524245e-03  1.895827e-02
## Val_T5            -2.826975e-02  9.506843e-02 -3.938249e-02  5.845612e-02
## Ala_T5            -2.444334e-02  3.754688e-04  1.057012e-02 -2.485855e-02
## Pro_T5            -6.138517e-02  8.456734e-02 -4.407137e-03 -8.928364e-02
## Gly_T5             2.256159e-02 -3.808204e-03  9.046876e-03  6.329486e-02
## Ser_T5            -2.051900e-02 -3.894390e-02  2.399399e-02 -8.501249e-03
## Trp_T5             5.241202e-02  1.856615e-02 -4.766627e-02  3.510451e-02
## Phe_T5            -6.803265e-02  6.525385e-02 -2.438022e-02 -1.686608e-02
## Met_T5             3.281770e-02  1.370370e-02 -2.627611e-02 -6.783614e-02
## Orn_T5            -1.289099e-02 -3.748112e-02 -2.048279e-02 -3.706453e-02
## Arg_T5             4.437063e-02 -1.239266e-02  3.887023e-03  7.998977e-02
## His_T5            -5.622365e-02  6.128382e-02  2.045188e-03  2.282216e-02
## Asn_T5            -1.014877e-01 -2.524992e-02  4.768320e-03 -8.965462e-02
## Asp_T5            -5.716459e-02  5.371626e-02 -4.437566e-02 -2.787588e-02
## Glu_T5             6.650561e-02  9.760607e-03  2.680373e-02  3.352352e-02
## Gln_T5            -1.054887e-01 -1.600436e-02 -1.886931e-02 -5.499753e-02
## Cit_T5            -1.072702e-01  2.702962e-02 -4.672066e-02  3.822929e-02
## Tyr_T5            -2.121925e-02  6.568040e-03 -1.632930e-02 -1.047446e-01
## Thr_T5            -6.406524e-02  6.102821e-02 -5.416587e-02 -2.893787e-02
## Lys_T5             6.169776e-02  7.071954e-02 -3.539628e-02  6.721611e-02
## Creatinine_T5     -2.950075e-02  4.622804e-02 -2.899898e-04 -2.416784e-02
## Kynurenine_T5      9.529266e-02 -9.706311e-03 -7.624938e-02 -6.400807e-03
## Putrescine_T5     -6.426129e-02  1.605630e-02 -5.318474e-02  1.671161e-02
## Sarcosine_T5      -7.629812e-02  8.715425e-02  1.079893e-02 -1.901496e-02
## Serotonin_T5      -6.875483e-02 -1.812511e-02 -2.494936e-02  1.013165e-01
## Taurine_T5        -6.661825e-02  8.476342e-02 -5.257247e-02 -1.536932e-01
## SDMA_T5            1.273393e-03  6.669647e-03 -1.496250e-03  7.472402e-03
## C0_T5              7.107287e-02  4.364648e-02 -3.889479e-02  7.017129e-02
## C2_T5              6.229803e-02  8.389036e-02 -1.027343e-02  5.141901e-02
## C3.OH_T5           5.766425e-04  1.699025e-03  3.407612e-03  4.513155e-03
## C6..C4.1.DC._T5   -5.541216e-02  9.998629e-02  3.145246e-02 -1.735505e-01
## C5.DC..C6.OH._T5  -3.419164e-02 -7.999951e-03 -9.979929e-03  5.164655e-02
## C7.DC_T5          -5.082467e-02  1.549199e-02 -2.190862e-02  1.798675e-02
## C8_T5              2.433200e-05  6.619215e-03  2.536661e-03  1.160011e-02
## C10_T5             4.648504e-04  1.086576e-02 -7.871088e-04  1.248654e-02
## C10.1_T5          -3.597069e-03  7.316071e-02 -5.112992e-02  2.521614e-02
## C10.2_T5          -2.879248e-04  2.082646e-03  2.910898e-03  2.785591e-03
## C14.1_T5           1.982849e-04  3.174771e-03  2.188628e-03  2.752668e-03
## C14.2_T5          -3.805271e-04  2.127277e-03  2.642841e-03  2.343229e-03
## C16.1_T5          -4.839571e-04  1.503781e-03  3.289972e-03  1.847540e-03
## C16.2_T5          -7.334044e-04  9.997878e-04  2.910110e-03  1.370850e-03
## C16.2.OH_T5        4.753160e-02 -4.352040e-02  6.514721e-02  5.118032e-02
## C18.1_T5          -2.728360e-04  1.327440e-03  2.544430e-03  9.088137e-04
## C18.1.OH_T5       -5.448195e-04  9.417668e-04  3.162776e-03  1.654159e-03
## C18.2_T5          -7.275322e-04  1.445578e-03  3.448112e-03  1.843226e-03
## lysoPC.a.C16.0_T5 -5.918469e-02  6.397535e-03  2.554940e-02 -4.400208e-02
## lysoPC.a.C16.1_T5 -6.554518e-02  1.304287e-02  2.660929e-02 -6.174621e-02
## lysoPC.a.C17.0_T5 -2.032970e-02  1.330498e-03 -4.016691e-03 -1.379653e-03
## lysoPC.a.C18.0_T5 -4.165100e-02 -2.711865e-02  2.592887e-02 -3.522536e-02
## lysoPC.a.C18.1_T5 -8.015555e-02 -1.839953e-02  3.193164e-02 -7.169892e-02
## lysoPC.a.C18.2_T5 -3.753834e-02 -4.753697e-02  3.439477e-02 -6.326926e-02
## lysoPC.a.C20.3_T5  1.504407e-02 -9.299572e-03  2.684530e-02 -3.065565e-02
## lysoPC.a.C20.4_T5  2.217338e-02 -4.086197e-02  2.422893e-02 -7.261905e-02
## lysoPC.a.C24.0_T5 -7.079186e-03  2.751878e-03  2.488362e-03  5.884898e-03
## lysoPC.a.C26.0_T5 -1.215757e-02  5.869605e-03  5.608570e-03  7.231116e-03
## lysoPC.a.C26.1_T5 -9.835987e-04  3.011186e-03  3.514608e-03  7.575950e-03
## lysoPC.a.C28.0_T5 -6.705423e-02 -4.182490e-02 -9.439820e-03  1.881973e-02
## lysoPC.a.C28.1_T5 -3.589007e-03  3.963810e-03  3.297258e-03  5.404086e-03
## PC.aa.C24.0_T5    -1.520165e-02 -9.717384e-02 -1.207664e-02 -8.662240e-03
## PC.aa.C28.1_T5     4.815877e-03  4.750510e-03  3.671117e-03  1.007975e-02
## PC.aa.C30.0_T5    -1.374898e-03  5.457477e-03  4.600135e-03  2.892339e-03
## PC.aa.C32.0_T5    -2.441472e-02  7.598446e-03 -2.607389e-03 -4.355055e-02
## PC.aa.C32.1_T5    -1.126731e-03  9.078799e-03 -9.570046e-03 -2.334517e-02
## PC.aa.C32.3_T5    -1.578368e-03  2.174330e-03  2.471459e-03  2.899191e-03
## PC.aa.C34.1_T5     9.389333e-03 -1.924202e-02 -8.884574e-03 -1.189911e-02
## PC.aa.C34.2_T5     7.398243e-03 -5.208666e-03 -1.117389e-02  3.657786e-02
## PC.aa.C34.3_T5     5.098545e-02  1.839193e-02 -1.432668e-02  3.243323e-02
## PC.aa.C34.4_T5     5.298588e-03  3.101970e-03  2.614447e-03  3.720891e-03
## PC.aa.C36.0_T5    -2.881344e-02  9.024540e-03  3.277729e-03  2.046271e-02
## PC.aa.C36.1_T5    -6.005119e-03 -4.306534e-02  3.485792e-03 -2.037038e-02
## PC.aa.C36.2_T5     1.900708e-02 -3.408053e-02 -1.928141e-02  1.179801e-02
## PC.aa.C36.3_T5     3.029553e-02  1.626781e-02 -7.063769e-03 -1.974275e-03
## PC.aa.C36.4_T5     5.684072e-02 -1.205967e-02 -4.310921e-03 -2.387016e-02
## PC.aa.C36.5_T5     1.740887e-03  5.066035e-02 -4.086140e-02  6.129109e-02
## PC.aa.C38.0_T5    -4.983680e-02  9.381092e-03 -3.681809e-03 -1.506852e-03
## PC.aa.C38.1_T5    -4.287909e-02  1.185873e-02  1.147681e-02 -2.140268e-03
## PC.aa.C38.3_T5     6.422314e-02 -1.111482e-02  2.165365e-02  9.678585e-03
## PC.aa.C38.4_T5     8.537931e-02 -4.623884e-02  6.121190e-03  2.406207e-03
## PC.aa.C38.5_T5     4.695444e-02 -1.557805e-02 -2.675484e-03  1.486678e-02
## PC.aa.C38.6_T5    -2.500727e-02  2.181494e-02 -1.908359e-02  7.894354e-02
## PC.aa.C40.1_T5    -7.594319e-02 -2.106902e-02  1.277025e-02  4.953116e-02
## PC.aa.C40.2_T5    -2.050390e-02  7.185354e-03  1.642061e-02  4.866025e-03
## PC.aa.C40.3_T5    -2.798137e-02  7.885703e-03  1.582498e-02  4.322096e-03
## PC.aa.C40.4_T5    -8.294594e-03 -1.122626e-03  2.449390e-02  7.383588e-03
## PC.aa.C40.5_T5     8.074072e-03 -2.850004e-02  2.502696e-02  1.949720e-02
## PC.aa.C40.6_T5     1.407665e-03  6.023764e-03 -1.656764e-02  6.415946e-02
## PC.aa.C42.0_T5    -7.193645e-03  4.476364e-03  3.624367e-03 -8.142157e-03
## PC.aa.C42.1_T5    -5.611133e-03  3.412564e-03  3.592221e-03 -3.197704e-03
## PC.aa.C42.2_T5    -1.463151e-02  4.798664e-03  8.411637e-03  2.662988e-03
## PC.aa.C42.4_T5    -1.184998e-02  3.246323e-03  1.143670e-02  3.029367e-03
## PC.aa.C42.5_T5    -8.225948e-03  2.328199e-03  7.573494e-03  1.743895e-03
## PC.aa.C42.6_T5     4.668949e-03 -3.571032e-02 -3.024078e-02 -4.891028e-02
## PC.ae.C30.0_T5    -1.336987e-02  1.731220e-02 -3.265876e-02 -1.187367e-02
## PC.ae.C32.1_T5     5.820305e-03 -4.413149e-03 -5.258365e-03 -1.841190e-02
## PC.ae.C32.2_T5    -4.604439e-03  7.145050e-04  1.415791e-03 -8.614840e-04
## PC.ae.C34.0_T5     5.533407e-04 -1.162461e-03  1.876335e-03 -1.209878e-03
## PC.ae.C34.1_T5     1.735333e-02 -1.500111e-03 -1.834309e-02 -2.071614e-02
## PC.ae.C34.2_T5     1.771596e-02  6.743035e-04 -2.452367e-02 -1.585102e-02
## PC.ae.C34.3_T5     1.249906e-02  5.383625e-03 -3.771691e-03 -2.153739e-02
## PC.ae.C36.0_T5    -9.122838e-03 -2.552523e-03  4.283442e-03 -2.025777e-03
## PC.ae.C36.1_T5    -6.509284e-02  2.016282e-02  2.709270e-02  9.825684e-03
## PC.ae.C36.2_T5    -1.956342e-02  4.213038e-03 -2.829247e-02  2.533855e-02
## PC.ae.C36.3_T5    -1.283916e-03  1.704888e-02 -5.602802e-03 -1.581490e-02
## PC.ae.C36.4_T5     3.046142e-02 -1.771018e-02 -2.621915e-02 -5.872472e-02
## PC.ae.C36.5_T5     1.655516e-02 -2.728881e-02 -1.924893e-02 -2.953620e-02
## PC.ae.C38.0_T5    -3.668063e-03  4.203321e-03 -2.159609e-03  1.558643e-02
## PC.ae.C38.2_T5    -6.796540e-02  2.532005e-02  3.633431e-02  1.738817e-02
## PC.ae.C38.3_T5     3.226777e-02  8.062792e-03  3.125532e-02  2.366371e-02
## PC.ae.C38.4_T5     3.522579e-02 -9.024663e-03 -7.899123e-03 -1.423163e-02
## PC.ae.C38.5_T5    -8.880838e-03 -8.892285e-03 -1.086085e-02 -6.330055e-02
## PC.ae.C38.6_T5    -1.231890e-02  2.605106e-03 -1.924609e-02 -7.687933e-04
## PC.ae.C40.1_T5    -1.563262e-02  2.379945e-03  9.257024e-03  4.068045e-03
## PC.ae.C40.2_T5    -1.356979e-02  1.191084e-02  1.297754e-02  1.137412e-02
## PC.ae.C40.3_T5     2.098634e-02  7.848262e-03  3.351974e-02  1.776933e-02
## PC.ae.C40.4_T5    -7.106426e-03 -6.521422e-04  2.578670e-02 -1.631166e-03
## PC.ae.C40.5_T5     4.272696e-03  7.924883e-03  3.736924e-02 -4.166376e-03
## PC.ae.C40.6_T5    -1.241546e-02  7.759592e-03  5.897724e-04  5.738866e-03
## PC.ae.C42.1_T5    -7.878662e-03  4.312717e-03  1.008655e-02  3.926387e-03
## PC.ae.C42.2_T5    -1.034993e-02  6.861331e-03  9.628673e-03  6.968290e-04
## PC.ae.C42.3_T5    -1.699272e-02  1.003974e-02  1.052967e-02  1.180314e-03
## PC.ae.C42.4_T5    -6.745711e-03  4.608796e-03  7.736108e-03 -5.163520e-03
## PC.ae.C42.5_T5     1.156860e-02 -4.156430e-03  2.167070e-02 -2.389179e-02
## PC.ae.C44.3_T5    -9.403399e-03  4.281731e-03  6.593407e-03  1.875237e-03
## PC.ae.C44.4_T5    -2.388976e-03  4.136077e-03  6.354441e-03 -2.392169e-03
## PC.ae.C44.5_T5     1.720753e-02  7.691381e-03 -9.619912e-03 -3.338587e-02
## PC.ae.C44.6_T5     8.152685e-03  2.719654e-03 -2.807243e-03 -2.532016e-02
## SM..OH..C14.1_T5   1.351241e-02  1.608400e-02 -1.964000e-02  3.118450e-02
## SM..OH..C16.1_T5   6.221486e-03  6.600213e-03 -5.855184e-03  3.006906e-03
## SM..OH..C22.1_T5   1.029574e-02  1.630085e-02 -1.791714e-02  8.337666e-02
## SM..OH..C22.2_T5   2.595380e-02  4.500628e-02 -2.155923e-02  6.270444e-02
## SM..OH..C24.1_T5  -3.865653e-04  3.897812e-03  1.494272e-03  7.284430e-03
## SM.C16.0_T5        1.092952e-02  2.160591e-02  4.890286e-03  3.377397e-02
## SM.C16.1_T5        2.699232e-02  3.274674e-02  5.658439e-04  5.380719e-02
## SM.C18.0_T5        5.560081e-02  2.052028e-02  3.271713e-02 -3.880701e-02
## SM.C18.1_T5        6.950989e-02  3.380155e-02  5.275534e-03 -8.057623e-03
## SM.C20.2_T5       -7.482163e-04  3.915984e-03  2.728008e-03  1.183930e-03
## SM.C24.0_T5       -5.734913e-03  2.496196e-02  6.956574e-04  1.011805e-01
## SM.C24.1_T5        1.721927e-02  5.153144e-02  1.739368e-02  4.402552e-02
##                            PC21          PC22          PC23          PC24
## GLU_T0            -2.660904e-03  1.017133e-03  9.489369e-02 -1.463972e-01
## INS_T0            -7.664985e-02  1.472125e-02  5.694250e-02 -3.423064e-02
## HOMA_T0           -5.015224e-02  8.590032e-03  7.626397e-02 -6.799401e-02
## HBA1C_T0          -1.305859e-02  2.758540e-02 -1.241834e-02  1.445865e-02
## HBA1C.mmol.mol_T0  2.715487e-03  4.632943e-02 -2.868234e-02  1.883234e-02
## PESO_T0            4.358539e-02 -4.819771e-02 -1.975462e-02  1.690658e-03
## bmi_T0             8.194675e-02 -1.589245e-02 -3.442594e-03  3.159154e-02
## CC_T0             -5.557655e-03 -5.462141e-03  1.027548e-03  1.486506e-02
## CINT_T0           -4.587460e-03 -2.168875e-02  1.554266e-02  4.766560e-02
## CAD_T0            -7.904624e-03  9.704495e-02 -2.746324e-02 -1.341494e-02
## TAD_T0             8.188016e-02 -1.373494e-02 -3.020119e-02  2.910485e-02
## TAS_T0             7.059031e-02 -1.926044e-02  6.153269e-02  5.182175e-02
## TG_T0             -3.036266e-02  9.404918e-02 -2.861136e-02  5.869965e-02
## COL_T0            -3.580579e-02 -7.037485e-03  4.684837e-02  4.143166e-02
## LDL_T0            -4.026272e-02 -2.871084e-02 -4.250826e-03  2.830872e-02
## HDL_T0            -4.035605e-02 -1.037590e-01  1.392393e-01 -2.476838e-02
## VLDL_T0           -3.158190e-02  9.553066e-02 -2.886993e-02  5.966530e-02
## PCR_T0             1.981787e-02 -1.004087e-01  7.348809e-02 -1.285529e-02
## LEP_T0             8.375946e-02  6.697929e-03 -9.550603e-02  1.897002e-03
## ADIPO_T0           1.058470e-02 -9.762073e-02 -7.889339e-02 -5.278824e-02
## GOT_T0             5.835502e-02  9.555714e-02  8.792123e-02 -1.327353e-01
## GPT_T0            -2.275780e-02  4.831187e-02  3.150132e-02 -8.540781e-02
## GGT_T0             2.819636e-02 -2.465380e-02 -5.291562e-02 -4.976560e-02
## URICO_T0           7.319150e-03  2.819820e-02 -3.885160e-02  2.060979e-04
## CREAT_T0          -1.127715e-02  1.204082e-02 -5.170258e-04  8.123476e-03
## UREA_T0           -2.173875e-02 -5.794882e-03  8.976738e-03  8.502152e-02
## HIERRO_T0          2.961958e-02  5.247408e-02  3.712242e-02 -5.932121e-02
## TRANSF_T0         -7.991814e-02 -5.297309e-04  2.331229e-02  1.893758e-02
## FERR_T0            5.594256e-02 -1.090745e-02  6.267454e-02 -4.431604e-02
## Ile_T0             3.395651e-03  2.304603e-02 -1.056735e-01 -5.987706e-03
## Leu_T0             4.970968e-02  1.821549e-02 -5.042700e-02  3.728352e-03
## Val_T0             1.689927e-02  7.532976e-03 -1.373951e-02  3.432954e-03
## Ala_T0             6.604340e-02 -1.660397e-02 -1.462294e-02 -7.373428e-02
## Pro_T0             2.782039e-02  2.401809e-02 -5.564526e-02 -8.057570e-02
## Gly_T0            -7.761953e-02  1.001663e-02 -4.639539e-02 -8.581869e-02
## Ser_T0             4.327584e-02  3.152186e-02  2.159147e-02 -9.804476e-04
## Trp_T0             5.787379e-02 -4.276533e-02  2.789210e-02 -3.060454e-02
## Phe_T0             1.104121e-01 -5.295521e-02  4.733975e-02 -5.226069e-02
## Met_T0             1.017366e-02  1.235856e-02  3.518358e-03 -2.189554e-02
## Orn_T0             3.822309e-02  7.602203e-02 -8.135143e-02 -7.536793e-02
## Arg_T0             5.557682e-02 -1.010432e-01 -2.845934e-02  2.310187e-02
## His_T0             1.729179e-02  7.682785e-02 -8.215211e-03 -1.002662e-01
## Asn_T0             6.900797e-02 -4.080765e-03  1.872903e-02 -9.923161e-02
## Asp_T0             2.955212e-02 -2.622420e-02  7.966970e-02  4.054407e-03
## Glu_T0             8.262029e-04  1.876110e-02  2.118263e-02  3.193098e-02
## Gln_T0             2.306887e-02  8.280404e-02 -2.659546e-02 -2.212773e-02
## Cit_T0             1.516162e-02 -4.609605e-03 -1.118956e-02 -9.433486e-02
## Tyr_T0             1.334120e-01  2.554741e-02 -8.618099e-03 -2.198119e-02
## Thr_T0             5.929230e-02  2.291329e-03 -7.200678e-02 -1.115989e-01
## Lys_T0            -2.549142e-02  7.789991e-02 -8.820467e-02 -3.072685e-02
## Creatinine_T0      4.430811e-02  2.129597e-02  2.456332e-02  7.690757e-02
## Kynurenine_T0      4.820368e-02 -1.745607e-02 -7.128262e-03 -9.945709e-03
## Putrescine_T0     -5.399463e-02 -4.691128e-02 -4.334442e-02 -1.598777e-01
## Sarcosine_T0      -3.221132e-02 -1.483003e-02 -6.538133e-02 -1.935448e-03
## Serotonin_T0       2.765412e-02  7.205205e-02  5.319443e-02  2.049851e-01
## Taurine_T0         1.106887e-01 -1.746091e-02  1.196136e-01  7.765279e-02
## SDMA_T0            4.754986e-04  1.150961e-02  1.620961e-03  1.148604e-02
## C0_T0              6.460713e-02  5.096983e-02 -3.309087e-02  2.727628e-02
## C2_T0              5.490867e-02 -1.735666e-02  2.675310e-02  1.209811e-01
## C3.OH_T0          -5.406346e-03  5.587244e-03 -1.006682e-03  3.914717e-03
## C6..C4.1.DC._T0   -9.276023e-02  1.412857e-01  3.276223e-02  7.502015e-02
## C5.DC..C6.OH._T0  -6.901117e-02  4.098150e-03 -4.340927e-02  3.198907e-05
## C7.DC_T0           1.324376e-02  1.223507e-02 -3.577122e-02  6.131771e-03
## C8_T0             -2.520103e-03  7.881745e-03 -1.888201e-03  1.711657e-03
## C10_T0            -5.753430e-03  7.091076e-03  3.869226e-03  1.271581e-03
## C10.1_T0          -3.997122e-03  6.021989e-03  6.406460e-04  1.358133e-03
## C10.2_T0          -6.456550e-03  5.168369e-03 -1.310472e-03  2.398501e-03
## C14.1_T0          -4.023852e-03  3.409407e-03  1.485420e-03  5.268622e-03
## C14.2_T0          -4.873070e-03  5.433458e-03 -2.455833e-04  3.842981e-03
## C16.1_T0          -5.090879e-03  4.325183e-03 -1.168654e-03  4.216949e-03
## C16.2_T0          -5.202726e-03  4.690172e-03 -8.108974e-05  3.500349e-03
## C16.2.OH_T0       -5.809423e-03  4.475587e-03 -3.839762e-04  3.435325e-03
## C18.1_T0          -3.672698e-03  3.871774e-03  8.380528e-04  5.225071e-03
## C18.1.OH_T0       -5.716876e-03  4.665758e-03 -2.945549e-04  3.344407e-03
## C18.2_T0          -3.930321e-03  5.617024e-03  3.351362e-06  4.338852e-03
## lysoPC.a.C16.0_T0 -2.134343e-02  3.743800e-03  1.287191e-02  4.394119e-02
## lysoPC.a.C16.1_T0  7.748809e-04 -1.607392e-02 -2.014709e-03  2.299559e-02
## lysoPC.a.C17.0_T0 -5.403075e-03 -3.238671e-03 -2.266306e-03  9.910772e-03
## lysoPC.a.C18.0_T0 -2.629219e-02 -2.892140e-02  4.434385e-03  2.599563e-02
## lysoPC.a.C18.1_T0 -5.245793e-02 -6.163163e-02  1.398347e-02  2.378385e-02
## lysoPC.a.C18.2_T0 -5.820817e-02 -1.750238e-02  1.780834e-02 -4.250961e-02
## lysoPC.a.C20.3_T0  3.014886e-03 -4.147989e-02  4.142017e-03  2.705076e-02
## lysoPC.a.C20.4_T0 -6.945572e-02 -2.052838e-02  3.417776e-02 -1.561288e-02
## lysoPC.a.C24.0_T0 -6.845912e-03  7.686118e-03  8.344806e-04  4.087006e-03
## lysoPC.a.C26.0_T0 -5.847114e-02  2.904459e-02 -5.320172e-03 -4.019862e-03
## lysoPC.a.C26.1_T0 -1.254706e-02 -1.130307e-04 -3.521323e-03  7.100026e-04
## lysoPC.a.C28.0_T0 -1.060572e-02 -5.662747e-02  9.422890e-02 -6.844535e-02
## lysoPC.a.C28.1_T0 -7.672318e-03 -6.356979e-04 -3.711990e-03  6.269812e-03
## PC.aa.C24.0_T0    -1.616366e-01  3.171936e-02 -2.766906e-02  2.039084e-03
## PC.aa.C28.1_T0    -4.251611e-03 -2.388648e-03  3.239090e-03  2.383256e-02
## PC.aa.C30.0_T0    -4.221711e-02  1.394274e-02  1.109975e-02  1.417078e-02
## PC.aa.C32.0_T0    -3.458645e-02  1.723584e-02 -1.907953e-02  1.220014e-02
## PC.aa.C32.1_T0    -9.024864e-03 -1.422043e-03  1.615664e-02  3.592131e-02
## PC.aa.C32.3_T0    -6.091637e-03  4.037644e-03 -1.297045e-04  2.379098e-03
## PC.aa.C34.1_T0    -5.834127e-02 -7.706651e-02  8.000328e-03  1.309401e-02
## PC.aa.C34.2_T0     3.532217e-03  4.543362e-02  2.367754e-02 -3.303962e-02
## PC.aa.C34.3_T0     1.411124e-03 -1.656373e-02 -5.803398e-03  2.817519e-02
## PC.aa.C34.4_T0    -2.137011e-02  1.625245e-03 -1.324589e-03  4.838159e-04
## PC.aa.C36.0_T0     6.120939e-04 -4.485794e-03 -1.590091e-03  5.212269e-03
## PC.aa.C36.1_T0    -3.404000e-02 -1.057271e-01 -1.702225e-02 -4.045330e-03
## PC.aa.C36.2_T0    -1.377041e-02 -4.857371e-02 -1.621517e-02 -1.957323e-02
## PC.aa.C36.3_T0     2.668125e-02 -2.053750e-02  2.529809e-02 -1.546980e-02
## PC.aa.C36.4_T0    -9.370333e-02  3.446336e-02  4.108394e-02 -3.564227e-02
## PC.aa.C36.5_T0    -1.091772e-01  5.696176e-02  8.471169e-02  2.257125e-02
## PC.aa.C38.0_T0     8.306569e-03 -7.997263e-03  1.224780e-02  1.689547e-02
## PC.aa.C38.1_T0     3.698873e-02 -5.059621e-02 -4.378150e-02  7.533228e-03
## PC.aa.C38.3_T0     3.507486e-02 -8.082852e-02 -2.706213e-02  1.343877e-02
## PC.aa.C38.4_T0    -5.948573e-02  6.825259e-03  2.574987e-03 -4.958849e-02
## PC.aa.C38.5_T0    -8.545998e-02  8.934315e-03  7.762100e-03 -2.279510e-02
## PC.aa.C38.6_T0    -1.800701e-02  5.550767e-02  4.138029e-02  8.583107e-02
## PC.aa.C40.1_T0     7.125208e-02 -9.475528e-03  1.413530e-01 -8.927423e-04
## PC.aa.C40.2_T0    -2.243557e-03 -2.544980e-03 -4.242697e-03  9.587743e-04
## PC.aa.C40.3_T0    -2.858170e-03 -2.753460e-03 -1.133894e-02  6.168490e-03
## PC.aa.C40.4_T0    -3.836378e-03 -3.538479e-03 -2.879267e-02 -7.240184e-03
## PC.aa.C40.5_T0     5.716488e-03 -7.146566e-03 -4.987869e-02 -9.341846e-03
## PC.aa.C40.6_T0    -9.390358e-04  3.942724e-02 -2.390936e-02  7.186921e-02
## PC.aa.C42.0_T0    -2.490441e-03  2.638444e-03 -1.898260e-03  3.173319e-03
## PC.aa.C42.1_T0    -4.493872e-03  4.150011e-03 -2.722040e-03  5.043364e-03
## PC.aa.C42.2_T0    -4.879546e-03  5.173603e-03 -4.529910e-03  5.944500e-03
## PC.aa.C42.4_T0    -4.888651e-03  2.033107e-03 -3.411676e-03  2.861894e-03
## PC.aa.C42.5_T0    -4.674271e-03  3.802810e-03 -3.034824e-03  2.211064e-03
## PC.aa.C42.6_T0    -9.904419e-03  5.463189e-02  5.569172e-02 -1.512833e-02
## PC.ae.C30.0_T0    -6.533212e-03  5.949881e-03  1.286286e-03  4.533220e-03
## PC.ae.C32.1_T0     9.652063e-04 -5.016575e-04 -1.101362e-03 -4.312423e-03
## PC.ae.C32.2_T0    -5.094422e-03  2.769860e-04 -3.885245e-03  2.635403e-03
## PC.ae.C34.0_T0    -4.996940e-03  4.864672e-03 -3.256860e-03  2.824093e-03
## PC.ae.C34.1_T0     1.545725e-02 -3.402509e-02  8.286210e-03  1.472431e-02
## PC.ae.C34.2_T0     2.846537e-02 -5.585550e-02 -1.590988e-02  6.477958e-03
## PC.ae.C34.3_T0     1.427904e-02 -2.568299e-02 -4.437586e-03  1.485059e-02
## PC.ae.C36.0_T0    -8.351106e-04  2.626941e-04 -3.351730e-03  6.177560e-03
## PC.ae.C36.1_T0     3.759408e-03 -1.513598e-02 -8.792128e-03  6.726114e-03
## PC.ae.C36.2_T0     1.609175e-02 -1.773599e-02 -1.920867e-02 -6.683460e-03
## PC.ae.C36.3_T0     3.974742e-02 -5.654343e-02 -3.367762e-03  1.273893e-02
## PC.ae.C36.4_T0     1.123678e-02 -9.162782e-02 -8.883070e-03 -4.011241e-02
## PC.ae.C36.5_T0    -6.764726e-03 -4.319059e-02 -1.093138e-02 -6.057921e-02
## PC.ae.C38.0_T0    -1.031633e-02  5.048450e-03  5.396925e-03  7.627883e-03
## PC.ae.C38.2_T0     6.374635e-04 -7.358313e-03 -1.083271e-02 -3.534681e-03
## PC.ae.C38.3_T0     1.302106e-02 -8.213513e-03 -7.831394e-03  8.138747e-03
## PC.ae.C38.4_T0     2.270922e-02 -1.504780e-02 -5.387053e-04 -4.755621e-02
## PC.ae.C38.5_T0     3.414178e-02 -9.235962e-02 -3.632915e-03 -2.321505e-02
## PC.ae.C38.6_T0     5.190681e-03 -2.565139e-02  1.423045e-02  1.095885e-02
## PC.ae.C40.1_T0    -1.706994e-02  1.042788e-03 -2.454399e-03  5.361070e-03
## PC.ae.C40.2_T0     7.114985e-03 -4.440692e-03 -1.306797e-03  7.998088e-03
## PC.ae.C40.3_T0     9.625826e-03 -2.033411e-03 -6.665684e-03  6.851542e-03
## PC.ae.C40.4_T0     7.898862e-03  5.767171e-04 -3.129890e-05 -5.692637e-03
## PC.ae.C40.5_T0     8.174889e-03 -4.023269e-03  6.415351e-04 -7.450802e-03
## PC.ae.C40.6_T0     4.309265e-03  3.084836e-03  2.410586e-04  9.360345e-03
## PC.ae.C42.1_T0    -5.042294e-03  2.054160e-04 -6.734174e-03  1.866176e-03
## PC.ae.C42.2_T0    -3.474823e-03 -3.885444e-04 -1.268969e-03  7.053560e-03
## PC.ae.C42.3_T0    -5.103258e-03 -3.846605e-04 -1.519939e-03  9.248121e-03
## PC.ae.C42.4_T0     3.024904e-03 -7.325530e-04 -8.973668e-04  1.550448e-03
## PC.ae.C42.5_T0     4.301815e-03  3.039509e-03 -5.654119e-05  1.290757e-04
## PC.ae.C44.3_T0    -5.622527e-03  1.575303e-03 -2.346358e-03  3.835481e-03
## PC.ae.C44.4_T0     5.504026e-04  1.195374e-03 -2.953591e-03  8.001748e-03
## PC.ae.C44.5_T0     1.109976e-02 -1.400341e-02  9.287683e-04  1.001067e-02
## PC.ae.C44.6_T0    -2.694147e-03  1.097528e-02 -3.462870e-04  6.250188e-03
## SM..OH..C14.1_T0   3.049254e-02 -1.929500e-02 -2.492272e-02  3.385236e-02
## SM..OH..C16.1_T0   9.609168e-03 -6.424030e-03 -7.719562e-03  1.469116e-02
## SM..OH..C22.1_T0  -2.189725e-03 -6.166216e-02  4.448778e-02  2.585237e-02
## SM..OH..C22.2_T0   1.534506e-02 -4.641121e-02  1.075477e-02  5.387071e-02
## SM..OH..C24.1_T0   2.775985e-03  2.395038e-04  4.298799e-03  9.593728e-03
## SM.C16.0_T0       -5.203024e-03 -9.967891e-02 -2.948147e-02  4.742703e-02
## SM.C16.1_T0        1.472698e-02 -9.321720e-02  1.694619e-02  6.101777e-02
## SM.C18.0_T0        6.433952e-03 -2.117095e-02 -2.293661e-02  5.613905e-02
## SM.C18.1_T0        7.330947e-03 -2.257162e-02  3.549909e-02  4.680275e-02
## SM.C20.2_T0       -5.169666e-03  3.252993e-03 -1.147687e-03  2.883341e-03
## SM.C24.0_T0       -1.892334e-02 -5.087931e-02 -3.612703e-03  2.275833e-02
## SM.C24.1_T0        2.550854e-02 -6.951043e-02 -2.658977e-02  8.235152e-02
## MEDDM_T2          -5.647053e-03  4.332562e-03 -2.164938e-04  2.939173e-03
## MEDCOL_T2         -5.647053e-03  4.332562e-03 -2.164938e-04  2.939173e-03
## MEDINF_T2         -1.914760e-02  5.161343e-03 -9.015937e-03 -2.859771e-03
## MEDHTA_T2         -1.374323e-02  2.906695e-03 -1.174204e-02 -1.585824e-03
## GLU_T2             2.716340e-02  7.064815e-02 -1.500781e-03 -3.103372e-02
## INS_T2             3.462670e-02 -3.144018e-02  9.185568e-02 -9.121508e-02
## HOMA_T2            1.678498e-02 -3.152628e-03  5.741918e-02 -6.409010e-02
## HBA1C_T2          -2.328997e-02  2.222714e-02 -1.939861e-03  1.540459e-02
## HBA1C.mmol.mol_T2 -3.863300e-02  4.307448e-02  2.088484e-03  3.021217e-02
## PESO_T2            2.508410e-02 -6.724665e-02 -1.335381e-02  5.441241e-03
## bmi_T2             7.033280e-02 -3.390832e-02  1.068669e-02  4.791537e-02
## CC_T2             -1.236467e-02  4.594047e-03 -1.133727e-03  4.983190e-03
## CINT_T2           -3.463027e-02 -3.057984e-02  3.643843e-03  3.719033e-02
## CAD_T2             3.331080e-02  4.362142e-03  2.656497e-02  4.213692e-02
## TAD_T2             4.071224e-02  2.379414e-02  8.893025e-02 -5.311398e-02
## TAS_T2             7.975247e-02  6.910725e-03  4.092092e-02 -3.077764e-02
## TG_T2              8.670518e-02  4.974422e-02 -6.410668e-02  7.821884e-02
## COL_T2             2.990573e-02  1.367541e-02  1.478802e-02  3.146150e-02
## LDL_T2             6.730292e-03  1.027524e-02  1.398044e-02  4.721617e-02
## HDL_T2            -3.118468e-02 -1.339647e-02  3.909516e-03 -6.517669e-02
## VLDL_T2            7.493219e-02  4.610652e-02  1.052768e-02  6.499330e-02
## PCR_T2             2.406686e-02 -2.421502e-02  9.946925e-02 -6.720439e-03
## LEP_T2             1.616393e-01  9.551618e-03 -1.233722e-01 -1.445196e-02
## ADIPO_T2           1.883187e-02 -9.581942e-02 -8.340251e-02  1.821099e-02
## GOT_T2            -6.366960e-03  2.122981e-02  9.091510e-02 -1.324892e-01
## GPT_T2            -1.274907e-01 -2.192959e-02  7.380633e-02 -2.806278e-02
## GGT_T2            -5.072136e-03 -1.183896e-02 -1.539996e-01 -6.822001e-03
## URICO_T2           4.046120e-02  7.532450e-02  3.697128e-02  4.437855e-03
## CREAT_T2          -2.379394e-03  1.880537e-03  2.211570e-03  6.283827e-03
## UREA_T2            1.191456e-01  9.253559e-02 -1.533211e-01 -2.664027e-02
## HIERRO_T2          1.330138e-01  1.130590e-01  1.312023e-01  1.464896e-02
## TRANSF_T2         -6.661902e-02 -6.682500e-03 -3.469919e-02  4.271203e-03
## FERR_T2            9.107312e-02 -5.547831e-04 -6.635881e-03 -6.193044e-02
## Ile_T2             1.079236e-02  3.396355e-02  1.211537e-03  3.260166e-02
## Leu_T2             1.005543e-02  4.809037e-02 -2.065583e-02 -2.038056e-02
## Val_T2             3.112768e-03  1.959982e-02 -2.584322e-02 -1.778443e-02
## Ala_T2             7.487821e-02  2.078153e-02  5.992179e-02  2.313938e-03
## Pro_T2             1.983822e-02  4.536243e-02 -2.447678e-03 -4.206498e-02
## Gly_T2            -1.104231e-01  2.892966e-03  6.525290e-03  1.366471e-02
## Ser_T2            -1.378367e-01  4.827872e-02  6.469087e-02  1.428006e-02
## Trp_T2            -3.534670e-02 -1.449500e-02 -8.599155e-03  1.979101e-02
## Phe_T2            -5.809973e-04  5.718736e-02 -4.945535e-03 -8.461445e-02
## Met_T2             2.540210e-02 -8.330509e-03 -2.929490e-02 -9.610980e-03
## Orn_T2            -6.273824e-02  3.297679e-02  1.408285e-02  1.880508e-02
## Arg_T2            -2.248062e-02  1.440731e-02  2.103565e-02 -2.601225e-02
## His_T2            -4.083747e-02  4.823196e-02  1.455390e-02 -6.076379e-02
## Asn_T2            -5.986992e-03  4.941951e-02 -3.641842e-02  7.609891e-03
## Asp_T2             3.030385e-02 -4.225531e-02 -4.954397e-02  1.741965e-02
## Glu_T2             3.456695e-02  3.337941e-02  4.270252e-02  2.877535e-02
## Gln_T2            -2.238406e-02 -1.814964e-02  5.409253e-02  5.942386e-02
## Cit_T2             3.279962e-02  1.581571e-02 -1.323972e-02  2.117800e-02
## Tyr_T2             2.871365e-02  8.094222e-02  4.212957e-02 -4.082473e-02
## Thr_T2            -8.997719e-03  9.399578e-02  5.469209e-02 -2.051561e-02
## Lys_T2            -5.244900e-02  3.757511e-02  5.362147e-03 -9.727781e-04
## Creatinine_T2      1.561004e-02  3.150553e-02 -4.469933e-02 -1.782099e-02
## Kynurenine_T2      1.108584e-02  3.536700e-03 -2.426323e-02 -1.672419e-02
## Putrescine_T2      6.885393e-02  4.070253e-02  1.384271e-01  4.673640e-02
## Sarcosine_T2       1.588803e-03  2.673061e-02 -2.657869e-02  7.388833e-02
## Serotonin_T2      -3.134583e-03 -8.759220e-02 -1.268502e-02  3.239083e-02
## Taurine_T2         1.049097e-02 -1.144086e-01 -1.228118e-02  3.825956e-02
## SDMA_T2            7.483506e-03  1.949727e-02 -6.483341e-03 -8.912980e-03
## C0_T2             -2.003742e-02 -3.725999e-02 -7.072928e-03  2.575559e-02
## C2_T2             -1.701185e-02  5.250649e-02 -8.090352e-03  4.638326e-02
## C3.OH_T2          -6.723606e-03  6.141254e-03  9.222234e-04  1.618005e-03
## C6..C4.1.DC._T2   -5.928673e-02  1.677235e-01  1.120311e-01  6.964081e-02
## C5.DC..C6.OH._T2  -4.724031e-02 -1.019853e-01 -1.598378e-02 -1.517626e-01
## C7.DC_T2          -2.765650e-02 -2.803394e-02  3.427247e-02 -7.477050e-02
## C8_T2             -5.728947e-03  7.073062e-03  3.643668e-03 -3.890490e-04
## C10_T2            -1.335346e-04  3.477713e-03  9.447104e-03 -4.596706e-03
## C10.1_T2          -4.593452e-03  5.727387e-03  1.931597e-03  6.075713e-04
## C10.2_T2          -6.749083e-03  4.539506e-03  7.573396e-04  3.233261e-03
## C14.1_T2          -9.325247e-04  5.447898e-03  3.656333e-03  2.913789e-03
## C14.2_T2          -3.266453e-03  6.481087e-03  1.404440e-03  2.836705e-03
## C16.1_T2          -3.734171e-03  5.429714e-03  3.100520e-05  3.399308e-03
## C16.2_T2          -5.139273e-03  4.754904e-03  7.624193e-04  3.385922e-03
## C16.2.OH_T2       -5.374274e-03  4.604203e-03 -2.227188e-05  3.019491e-03
## C18.1_T2          -3.765515e-03  4.571775e-03  2.847564e-03  2.673644e-03
## C18.1.OH_T2       -5.238710e-03  4.817083e-03  5.650617e-04  3.163231e-03
## C18.2_T2          -5.724921e-03  7.626283e-03  2.416288e-03  3.603615e-03
## lysoPC.a.C14.0_T2  4.804203e-02 -9.110435e-02  1.282267e-02 -1.760023e-03
## lysoPC.a.C16.0_T2 -1.944739e-02 -5.610710e-02  1.009667e-01  7.694070e-02
## lysoPC.a.C16.1_T2  2.888849e-02 -3.349453e-02  3.008299e-02  2.968252e-02
## lysoPC.a.C17.0_T2 -6.759379e-04 -7.276311e-03  2.603400e-04  1.889623e-02
## lysoPC.a.C18.0_T2  8.573847e-03 -4.714347e-02  6.141555e-02  4.642427e-02
## lysoPC.a.C18.1_T2  4.421627e-02 -8.246725e-02  8.119565e-02  4.354159e-02
## lysoPC.a.C18.2_T2 -6.127915e-03 -2.591090e-02  5.533266e-02  5.891621e-02
## lysoPC.a.C20.3_T2  2.142928e-02 -2.525092e-02 -2.134211e-03  9.152226e-03
## lysoPC.a.C20.4_T2 -1.886739e-02 -5.337222e-02  6.445766e-02  5.719489e-03
## lysoPC.a.C24.0_T2 -1.079554e-02  5.749952e-03  3.582219e-03  5.049893e-03
## lysoPC.a.C26.0_T2 -8.996303e-03  9.757192e-02  5.666218e-03 -6.695782e-02
## lysoPC.a.C26.1_T2 -9.990168e-03  4.113194e-03  6.749214e-03  5.122615e-03
## lysoPC.a.C28.0_T2  4.017201e-02 -3.522917e-02  4.442088e-02  6.764506e-02
## lysoPC.a.C28.1_T2 -7.603652e-03  4.470365e-03  6.742961e-03  1.853206e-03
## PC.aa.C24.0_T2     5.554916e-02  3.535899e-02 -2.892497e-02 -1.571072e-01
## PC.aa.C28.1_T2    -6.792857e-04  9.691182e-03 -1.583698e-03  1.382416e-02
## PC.aa.C30.0_T2    -8.791981e-03  7.566723e-03 -8.265771e-04 -1.250206e-02
## PC.aa.C32.0_T2    -3.800838e-02 -2.484743e-02 -4.105993e-03 -5.886669e-02
## PC.aa.C32.1_T2     3.752856e-02 -4.521059e-02 -3.298722e-02  1.793975e-02
## PC.aa.C32.3_T2    -6.445084e-03  4.359853e-03 -1.834523e-03  2.310004e-03
## PC.aa.C34.1_T2     3.258877e-02 -7.509129e-02  1.636045e-02 -2.041533e-03
## PC.aa.C34.2_T2    -5.022158e-03  2.925552e-02 -9.808112e-03  1.533776e-02
## PC.aa.C34.3_T2     1.793154e-02 -1.944263e-02 -5.021000e-02  3.208744e-02
## PC.aa.C34.4_T2    -2.895633e-03  2.738449e-03 -3.426609e-03  4.841654e-03
## PC.aa.C36.0_T2    -6.907551e-03  5.065437e-03  1.284010e-02  5.119886e-03
## PC.aa.C36.1_T2     1.140002e-02 -4.899864e-02  2.068607e-02 -1.224939e-02
## PC.aa.C36.2_T2     2.497729e-02 -1.778247e-02  6.393991e-03  7.080856e-03
## PC.aa.C36.3_T2     3.853570e-02 -3.476737e-02 -5.261683e-02 -2.071358e-02
## PC.aa.C36.4_T2    -6.683169e-02 -2.235015e-02 -1.004863e-02 -7.579776e-02
## PC.aa.C36.5_T2     6.838250e-02  3.982843e-03 -1.403392e-02  3.171266e-02
## PC.aa.C38.0_T2     5.989798e-03 -1.968162e-02  1.967961e-02 -2.148167e-03
## PC.aa.C38.1_T2    -1.201734e-02  3.444467e-03  4.367880e-03  6.239402e-02
## PC.aa.C38.3_T2     3.779344e-02 -4.547230e-02 -1.947005e-02 -1.445855e-02
## PC.aa.C38.4_T2    -1.715225e-02 -7.085962e-02 -1.845079e-02 -6.447090e-02
## PC.aa.C38.5_T2     2.916516e-02 -7.422598e-02 -4.308922e-02 -1.418022e-02
## PC.aa.C38.6_T2    -9.150250e-03 -6.287777e-02 -7.194321e-03  2.243587e-02
## PC.aa.C40.1_T2    -5.025455e-02 -3.007559e-03 -2.993545e-03 -6.814832e-02
## PC.aa.C40.2_T2    -1.091738e-02  7.083422e-03  1.200059e-02 -1.448739e-03
## PC.aa.C40.3_T2    -1.088373e-02  2.895125e-03  1.149036e-02 -2.472077e-04
## PC.aa.C40.4_T2    -1.419836e-02 -2.171985e-02 -9.682713e-03 -1.605446e-02
## PC.aa.C40.5_T2     5.690129e-03 -5.604116e-02 -2.263591e-02 -1.338214e-02
## PC.aa.C40.6_T2     9.359078e-03 -7.498030e-02 -5.580804e-03  3.622815e-02
## PC.aa.C42.0_T2    -4.434257e-03 -6.536096e-04  2.611072e-03 -4.636352e-03
## PC.aa.C42.1_T2    -6.706121e-03  3.194187e-03  2.673671e-03 -1.150074e-03
## PC.aa.C42.2_T2    -8.262254e-03  3.135930e-03  4.651893e-03  1.796301e-03
## PC.aa.C42.4_T2    -6.498891e-03  3.709008e-03  2.164396e-03  8.603802e-04
## PC.aa.C42.5_T2    -6.722100e-03  6.781413e-04  1.927441e-03  2.412219e-03
## PC.aa.C42.6_T2     6.993153e-02 -2.584284e-03 -6.940464e-02 -7.405866e-02
## PC.ae.C30.0_T2     1.382319e-01  5.071426e-02 -4.750294e-02  6.234329e-02
## PC.ae.C32.1_T2     2.999471e-03  5.808732e-03 -1.004281e-03 -1.884786e-02
## PC.ae.C32.2_T2    -4.823066e-03 -3.448834e-04 -5.328450e-04  1.478103e-03
## PC.ae.C34.0_T2    -4.597997e-03  6.485945e-03 -6.487735e-03 -1.587909e-03
## PC.ae.C34.1_T2     1.872385e-02 -1.521865e-02  5.834113e-03 -3.091390e-02
## PC.ae.C34.2_T2     6.975442e-03 -1.190303e-02 -3.395602e-03 -5.097485e-03
## PC.ae.C34.3_T2    -1.402924e-02 -9.662318e-03  1.237596e-03  1.332325e-02
## PC.ae.C36.0_T2    -6.995866e-03 -8.909829e-04  3.459556e-03 -2.224356e-03
## PC.ae.C36.1_T2    -5.541997e-03  5.239892e-03  2.453102e-02 -1.213874e-02
## PC.ae.C36.2_T2     1.251499e-02  6.103885e-03 -2.605660e-02 -2.357470e-03
## PC.ae.C36.3_T2     1.065060e-02 -6.031808e-03  8.649056e-03 -4.394099e-03
## PC.ae.C36.4_T2     8.137542e-03 -1.384398e-02 -3.157390e-03 -3.623133e-02
## PC.ae.C36.5_T2     3.188456e-03 -1.887045e-02 -2.079814e-03 -2.115953e-02
## PC.ae.C38.0_T2     2.736344e-03 -1.104218e-02 -6.084979e-03  1.424161e-02
## PC.ae.C38.2_T2    -1.443384e-02  7.702847e-03  2.640397e-02 -1.207711e-02
## PC.ae.C38.3_T2    -7.700341e-03  7.441143e-03  1.214162e-02 -1.283814e-02
## PC.ae.C38.4_T2     3.298992e-03 -1.418516e-02 -1.614363e-02 -3.864497e-02
## PC.ae.C38.5_T2     1.419973e-02 -3.483367e-02  2.003702e-02 -3.912264e-02
## PC.ae.C38.6_T2     1.750243e-03 -2.441967e-02  4.943319e-04 -1.132525e-02
## PC.ae.C40.1_T2    -1.259196e-02  2.162624e-04  1.119220e-02  7.522200e-03
## PC.ae.C40.2_T2     1.217117e-03  6.001922e-03  9.631739e-03 -4.553370e-03
## PC.ae.C40.3_T2    -1.094975e-02  6.588115e-03  1.836642e-02 -1.031902e-02
## PC.ae.C40.4_T2    -5.302424e-03  5.127576e-03  1.679691e-02 -1.372730e-02
## PC.ae.C40.5_T2    -3.852000e-03 -1.102239e-02  1.243155e-02 -1.722050e-02
## PC.ae.C40.6_T2     3.224532e-03 -8.090076e-03 -6.007182e-03 -5.383144e-03
## PC.ae.C42.1_T2    -9.316577e-03  5.651865e-03  5.444636e-03 -1.509460e-03
## PC.ae.C42.2_T2    -6.647905e-03  3.927427e-03  7.896672e-03  2.217682e-03
## PC.ae.C42.3_T2    -5.648440e-03  6.250042e-03  7.786561e-03  4.923425e-03
## PC.ae.C42.4_T2    -3.395588e-04  8.354888e-03  9.168212e-03 -5.723533e-03
## PC.ae.C42.5_T2     3.784640e-03 -1.138601e-02  2.090197e-02 -1.960646e-02
## PC.ae.C44.3_T2     2.072341e-02 -4.576393e-02 -6.356861e-02  5.396924e-03
## PC.ae.C44.4_T2    -4.920381e-03  5.433694e-03  2.089216e-03  1.833664e-03
## PC.ae.C44.5_T2     1.173774e-02 -1.191122e-02  1.455718e-02 -3.093515e-03
## PC.ae.C44.6_T2    -2.233828e-03  2.317780e-03  6.191623e-03 -3.434410e-03
## SM..OH..C14.1_T2   1.481211e-02  2.203863e-03 -4.398135e-04 -1.389084e-03
## SM..OH..C16.1_T2   8.859520e-03  5.012238e-03 -2.099675e-03 -7.379418e-03
## SM..OH..C22.1_T2   2.181656e-02  6.203827e-03  1.750249e-02  9.923480e-03
## SM..OH..C22.2_T2   1.768375e-02  3.489201e-03  1.275672e-02 -5.912787e-03
## SM..OH..C24.1_T2  -1.857330e-03  4.790593e-03  3.067397e-03  2.281870e-03
## SM.C16.0_T2       -6.366424e-03 -3.386829e-02  1.684031e-02  2.406161e-03
## SM.C16.1_T2       -1.639727e-02 -2.634012e-02 -4.344807e-04 -5.903990e-03
## SM.C18.0_T2        4.242775e-02  8.560488e-03 -2.673524e-03 -3.830637e-02
## SM.C18.1_T2       -7.260572e-03 -1.046593e-02 -9.008579e-03 -1.063372e-02
## SM.C20.2_T2       -6.517770e-03  3.846352e-03  5.755403e-05  5.949217e-04
## SM.C24.0_T2        1.315773e-02  1.478035e-03  3.247184e-02  2.164713e-02
## SM.C24.1_T2        3.786321e-02 -3.557987e-02  3.462546e-02  1.323666e-02
## MEDDM_T4           2.508434e-03  4.870160e-03 -4.776899e-03  2.677181e-03
## MEDCOL_T4         -1.384518e-02  1.225993e-02  1.322321e-03  3.109870e-03
## MEDINF_T4         -4.242920e-03 -8.359897e-03 -1.044165e-02  1.213151e-02
## MEDHTA_T4         -2.157971e-02  1.726334e-02  1.308972e-02 -7.248935e-03
## GLU_T4            -2.796766e-02  3.626081e-02 -3.187176e-02 -1.007246e-02
## INS_T4            -2.897064e-02  6.506788e-03  5.132772e-02 -6.639868e-02
## HOMA_T4           -1.326719e-02  7.525372e-03  1.366825e-02 -2.443525e-02
## HBA1C_T4          -1.997643e-02  2.748430e-02 -1.517388e-02  1.265312e-02
## HBA1C.mmol.mol_T4 -2.147223e-02  5.459895e-02 -4.292567e-02  1.655110e-02
## PESO_T4            2.301618e-02 -7.843506e-02 -2.520099e-02  7.751511e-03
## bmi_T4             6.432248e-02 -4.471862e-02 -3.767954e-03  4.777567e-02
## CC_T4             -1.253662e-02  1.879126e-02 -6.997433e-03  1.242675e-02
## CINT_T4           -5.362056e-02 -2.684733e-02 -7.185531e-03  3.165020e-02
## CAD_T4             2.014083e-02 -8.183955e-02  4.490191e-02 -1.929139e-02
## TAD_T4             3.610070e-02  3.786844e-02  8.902148e-03 -4.475886e-02
## TAS_T4            -5.910334e-03  5.994257e-02  4.121433e-02 -1.116807e-02
## TG_T4             -3.213873e-02  5.550445e-02 -8.396935e-02  2.319197e-02
## COL_T4             6.567734e-03  5.140433e-02  9.404397e-03  2.823289e-03
## LDL_T4             8.492874e-03  6.099565e-02  1.022495e-02  4.096304e-03
## HDL_T4             2.952112e-04 -1.711580e-02  2.950970e-02 -7.318850e-03
## VLDL_T4           -1.456424e-02  3.688473e-02 -1.405722e-02 -1.395398e-02
## PCR_T4             7.312830e-02 -1.042426e-01 -4.418798e-02 -3.752878e-02
## LEP_T4             1.599664e-01  7.029590e-02 -6.854348e-02 -6.437785e-03
## ADIPO_T4           1.877317e-02 -6.545773e-02 -7.842275e-02  2.602972e-02
## GOT_T4            -3.242940e-02  7.496264e-04  6.372312e-02 -1.592187e-03
## GPT_T4            -8.796385e-02 -1.567016e-02  5.696371e-02  8.241547e-02
## GGT_T4             1.027323e-02  7.945686e-02 -3.447359e-02  7.023728e-02
## URICO_T4          -4.813527e-03  1.965039e-02 -1.487337e-02  1.718731e-03
## CREAT_T4          -8.525386e-03  7.002448e-03 -7.570450e-03  3.753693e-03
## UREA_T4            5.385048e-02  1.110158e-02 -2.117312e-01 -3.046161e-02
## HIERRO_T4          1.181617e-01  3.963327e-02 -8.094247e-03 -9.731080e-02
## TRANSF_T4         -1.185584e-01  6.507996e-03 -1.984152e-02  9.846482e-03
## FERR_T4            5.774335e-02 -5.495662e-02 -8.044663e-03 -6.151897e-02
## Ile_T4            -1.967427e-04 -3.055432e-02 -8.360020e-02  2.498952e-02
## Leu_T4             2.257979e-02 -1.664303e-02 -7.917226e-02 -1.534312e-02
## Val_T4            -3.973642e-04  5.291291e-02 -6.404066e-02 -2.151953e-03
## Ala_T4             3.095796e-02 -3.535405e-02 -6.356472e-02  3.759823e-02
## Pro_T4            -1.164282e-03  8.968424e-02 -1.148549e-01  4.418561e-02
## Gly_T4            -6.912120e-02 -5.596814e-02  4.700065e-02  7.104190e-03
## Ser_T4            -8.443747e-02  6.608164e-02 -1.585138e-01 -2.560333e-02
## Trp_T4            -2.861821e-02 -3.808498e-03  2.848291e-02 -1.951224e-02
## Phe_T4             3.617479e-02  1.992278e-03 -5.594926e-02 -3.236459e-02
## Met_T4            -2.972295e-02 -4.308341e-03 -1.737468e-02 -1.067518e-02
## Orn_T4            -4.071618e-02  8.597385e-02 -1.042141e-02  1.203250e-01
## Arg_T4            -1.792825e-02 -6.547252e-02 -3.113070e-02  8.201527e-02
## His_T4            -8.187885e-03 -1.670941e-02  3.968147e-02 -3.124100e-02
## Asn_T4             1.042119e-02 -1.179582e-02  1.585498e-02  3.401079e-02
## Asp_T4             9.264415e-02 -1.268640e-01 -8.687490e-03  2.500465e-02
## Glu_T4             3.399174e-02 -2.201978e-02  3.663499e-02  6.316285e-02
## Gln_T4            -2.436204e-02 -4.475599e-02 -6.363202e-02  4.148409e-03
## Cit_T4            -3.161073e-03  4.811348e-02  3.952640e-02  7.604606e-02
## Tyr_T4             2.312036e-02  9.183821e-02 -8.943701e-02  6.007730e-02
## Thr_T4             2.387008e-02  1.617229e-02  5.117714e-02  2.464209e-02
## Lys_T4            -3.917993e-02 -1.886752e-01  8.332008e-02 -1.359798e-01
## Creatinine_T4      4.275386e-02 -8.285910e-02  5.566753e-02  4.498624e-02
## Kynurenine_T4     -1.644333e-01 -4.382565e-02 -6.412979e-02 -4.413363e-02
## Putrescine_T4     -7.301318e-02 -1.440920e-02 -6.166780e-03 -6.004165e-02
## Sarcosine_T4       5.367996e-02 -3.297248e-02 -6.715649e-03 -3.173486e-02
## Serotonin_T4      -1.119941e-02 -8.305339e-02 -2.816009e-03  3.067306e-02
## Taurine_T4        -5.143450e-04 -4.896481e-02  2.135425e-02  1.902580e-01
## SDMA_T4            6.813168e-03  7.647936e-04  5.812947e-03  1.030796e-02
## C0_T4             -5.733516e-02  7.925852e-02 -8.469695e-02  8.462246e-02
## C2_T4              2.083066e-02 -4.736085e-02  1.454934e-02  2.038693e-02
## C3.OH_T4          -8.187933e-03  5.291407e-03 -2.035788e-04 -3.216316e-04
## C6..C4.1.DC._T4   -5.332547e-02  3.281948e-02  7.952225e-02 -3.090727e-02
## C5.DC..C6.OH._T4  -2.404025e-02 -1.125975e-02  4.741985e-02 -5.950654e-03
## C7.DC_T4           7.170297e-02 -3.560200e-02  6.796280e-02  5.352362e-03
## C8_T4             -7.172460e-03  1.904332e-03  1.183668e-03 -4.948719e-03
## C10_T4             1.704737e-03 -1.765077e-03  6.622547e-03 -8.488984e-03
## C10.1_T4          -1.950357e-03  3.976535e-03  1.228558e-03  6.412111e-04
## C10.2_T4          -7.012335e-03  4.863610e-03  6.467764e-04  3.285210e-04
## C14.1_T4          -4.585043e-03  1.505333e-03  1.498130e-03  2.149498e-03
## C14.2_T4          -4.847810e-03  4.414798e-03  1.486645e-04  2.431060e-03
## C16.1_T4          -2.327870e-02 -6.239678e-03  8.153571e-02 -3.277827e-02
## C16.2_T4          -6.361499e-03  4.127998e-03 -7.578455e-04  2.908179e-03
## C16.2.OH_T4       -2.333395e-02 -5.653149e-03  8.100473e-02 -3.226099e-02
## C18.1_T4          -4.067647e-03  7.570343e-04  2.846456e-03  3.615752e-03
## C18.1.OH_T4       -6.119909e-03  4.188596e-03 -2.775104e-04  2.854606e-03
## C18.2_T4          -5.438666e-03  4.131768e-03  1.152314e-04  3.767473e-03
## lysoPC.a.C16.0_T4 -1.381257e-02 -7.097296e-03  2.784585e-02  4.963523e-02
## lysoPC.a.C16.1_T4  5.704631e-03 -2.719967e-02 -1.218288e-02  4.452730e-02
## lysoPC.a.C17.0_T4  2.675018e-03  2.626255e-02  9.364139e-04  1.623174e-02
## lysoPC.a.C18.0_T4  2.215515e-02  1.420911e-02  6.089263e-02  9.640186e-03
## lysoPC.a.C18.1_T4 -6.937168e-03 -1.902819e-02  5.327266e-02  1.473048e-02
## lysoPC.a.C18.2_T4  1.021252e-02 -9.080657e-03  7.605759e-03  5.059452e-02
## lysoPC.a.C20.3_T4 -2.608192e-02 -2.827310e-03 -2.717383e-02  2.028160e-02
## lysoPC.a.C20.4_T4 -3.601772e-02 -3.313640e-02  2.198117e-02 -2.255425e-02
## lysoPC.a.C24.0_T4 -1.021676e-02  8.409333e-03 -1.779476e-03 -2.444575e-04
## lysoPC.a.C26.0_T4 -9.304755e-02 -2.693065e-02 -2.794041e-02  7.476734e-02
## lysoPC.a.C26.1_T4 -1.453121e-02  4.484050e-03 -4.624069e-03  1.734890e-03
## lysoPC.a.C28.0_T4  6.154008e-02  2.038442e-03 -8.112585e-02 -8.188759e-02
## lysoPC.a.C28.1_T4 -1.014451e-02  7.388130e-03 -7.242066e-03  1.196955e-03
## PC.aa.C24.0_T4    -1.527911e-01  3.335566e-02  1.046086e-02 -3.122589e-02
## PC.aa.C28.1_T4    -7.254787e-03  8.014087e-03 -5.326452e-03 -1.496244e-04
## PC.aa.C30.0_T4    -2.019084e-02  1.208517e-03 -7.897741e-03 -1.104816e-02
## PC.aa.C32.0_T4     1.324747e-02 -2.092217e-03  2.884147e-02 -3.307938e-02
## PC.aa.C32.1_T4     2.803879e-02 -1.973467e-02 -4.958534e-02  2.664901e-02
## PC.aa.C32.3_T4    -5.085426e-03  3.905245e-03 -8.006566e-04  3.440716e-03
## PC.aa.C34.1_T4    -6.595726e-03 -9.846764e-04  2.508365e-02  4.610500e-03
## PC.aa.C34.2_T4     4.322501e-02  2.207347e-02  2.142425e-02  6.143162e-02
## PC.aa.C34.3_T4    -9.469286e-03  2.188451e-02 -4.364843e-02  8.648320e-02
## PC.aa.C34.4_T4    -9.660318e-03  8.820428e-03 -1.229211e-03  3.614071e-03
## PC.aa.C36.0_T4    -2.260315e-03  1.600287e-02  9.678507e-03  1.058111e-02
## PC.aa.C36.1_T4     1.601375e-03  1.509665e-02  6.619623e-02 -4.810951e-02
## PC.aa.C36.2_T4     4.442043e-02  2.028428e-02  6.110516e-02  4.318071e-02
## PC.aa.C36.3_T4    -2.944165e-02  3.323586e-02  7.603023e-03  2.493638e-02
## PC.aa.C36.4_T4    -3.854598e-02  3.684671e-02  1.195988e-02 -3.726904e-02
## PC.aa.C36.5_T4    -2.252797e-02  1.366816e-01 -3.385310e-02  1.277031e-02
## PC.aa.C38.0_T4     1.656264e-02  2.668836e-02  9.334643e-03 -1.000353e-02
## PC.aa.C38.1_T4     5.469469e-03  6.678147e-03  9.504219e-03 -1.046901e-02
## PC.aa.C38.3_T4    -1.976416e-02  1.584560e-02 -2.925924e-02 -3.538871e-02
## PC.aa.C38.4_T4    -1.994753e-02  3.774513e-02  2.486078e-02 -6.328470e-02
## PC.aa.C38.5_T4    -2.222147e-02  4.673839e-02 -1.821374e-02 -1.862563e-02
## PC.aa.C38.6_T4    -6.129141e-04  5.249354e-02 -1.021458e-02 -4.372803e-02
## PC.aa.C40.1_T4     7.152310e-02 -1.526180e-02  1.123455e-02 -2.216307e-02
## PC.aa.C40.2_T4     3.830389e-05  4.374812e-03  9.079790e-04  1.796629e-03
## PC.aa.C40.3_T4    -4.000145e-03  5.950825e-03 -2.612270e-03  3.100583e-03
## PC.aa.C40.4_T4    -6.871661e-03 -4.243698e-03 -9.323736e-03 -8.112658e-03
## PC.aa.C40.5_T4    -7.887108e-03  7.367724e-03 -3.048297e-03 -2.529517e-03
## PC.aa.C40.6_T4     1.632974e-02  2.024363e-02  4.194646e-03 -4.698708e-02
## PC.aa.C42.0_T4    -1.334421e-03  1.229716e-02 -3.190394e-03  2.897407e-03
## PC.aa.C42.1_T4    -3.369105e-03  5.858374e-03 -1.248847e-03  1.156329e-03
## PC.aa.C42.2_T4    -4.279150e-03  5.653893e-03 -4.599671e-04  6.683901e-04
## PC.aa.C42.4_T4    -2.639499e-03  2.986416e-03  1.471338e-04  1.565787e-03
## PC.aa.C42.5_T4    -5.535402e-03  4.098337e-03  8.503594e-04  6.685228e-04
## PC.aa.C42.6_T4    -8.652523e-02 -1.848144e-02 -2.349163e-02  4.991766e-02
## PC.ae.C30.0_T4     1.042870e-01  5.618084e-02 -4.831562e-02  1.944339e-02
## PC.ae.C32.1_T4     9.532226e-03  6.482226e-03  1.666047e-02 -4.195589e-03
## PC.ae.C32.2_T4    -6.461246e-04  7.661033e-03 -1.679511e-03  1.936868e-03
## PC.ae.C34.0_T4    -1.266336e-03  6.945387e-03  1.401022e-04  6.213203e-04
## PC.ae.C34.1_T4     3.060989e-02  2.108431e-03  3.531407e-02  9.101806e-03
## PC.ae.C34.2_T4     3.222867e-02  1.636585e-02  6.029575e-03  3.070680e-02
## PC.ae.C34.3_T4     4.114118e-02 -5.512996e-03  3.149864e-02  3.847484e-02
## PC.ae.C36.0_T4    -7.164558e-03  9.705851e-03  7.471223e-03 -1.510893e-03
## PC.ae.C36.1_T4     9.315830e-03  1.466162e-02  3.254249e-03 -1.747499e-02
## PC.ae.C36.2_T4     3.282826e-02  5.533273e-02 -8.756347e-03  3.053305e-02
## PC.ae.C36.3_T4     1.670650e-02  4.683757e-03  1.104073e-02  2.755198e-02
## PC.ae.C36.4_T4     3.937410e-02  1.033507e-02  3.148937e-02 -1.253070e-02
## PC.ae.C36.5_T4     2.110316e-02  3.050218e-02  2.678366e-02 -1.037593e-02
## PC.ae.C38.0_T4    -6.814011e-03  2.297505e-02 -9.929525e-03  1.003899e-02
## PC.ae.C38.2_T4     1.386379e-02  6.182628e-03  9.597137e-04  3.403381e-03
## PC.ae.C38.3_T4     1.007959e-02  4.716838e-03 -3.142989e-03  3.909301e-03
## PC.ae.C38.4_T4     2.710081e-02  2.273790e-02  2.304636e-02 -3.414765e-02
## PC.ae.C38.5_T4     3.239949e-02 -3.506096e-02  6.151785e-02 -3.199994e-02
## PC.ae.C38.6_T4     1.056011e-02  1.014550e-02  1.618036e-02 -1.835603e-04
## PC.ae.C40.1_T4    -6.809151e-03  1.987709e-02 -2.619125e-03  3.556002e-03
## PC.ae.C40.2_T4     1.182944e-02  3.943378e-03  9.352693e-03 -8.270877e-03
## PC.ae.C40.3_T4     1.516808e-02  4.206094e-03 -2.697602e-03  6.250806e-04
## PC.ae.C40.4_T4     1.535261e-02  1.204341e-02  1.332582e-02 -4.529246e-03
## PC.ae.C40.5_T4     1.733183e-02 -1.166012e-02  1.864294e-02 -2.016295e-02
## PC.ae.C40.6_T4     7.411119e-03  2.107496e-02  1.183315e-02 -7.537284e-03
## PC.ae.C42.1_T4    -3.183858e-03  5.574680e-03 -2.810018e-03  2.171316e-03
## PC.ae.C42.2_T4    -2.628540e-03  1.379839e-03 -3.671398e-03  6.641031e-03
## PC.ae.C42.3_T4     1.713493e-03  8.480083e-03 -9.635469e-04  6.874990e-03
## PC.ae.C42.4_T4     2.547868e-03  8.750867e-03  2.521791e-03  1.520830e-03
## PC.ae.C42.5_T4     1.431299e-02  9.628487e-03  2.046082e-02 -1.371107e-02
## PC.ae.C44.3_T4    -5.040785e-03  3.879295e-03 -1.109215e-03  3.013444e-03
## PC.ae.C44.4_T4    -2.511094e-03  5.028627e-03  1.429768e-03  5.044472e-03
## PC.ae.C44.5_T4     1.590095e-02 -1.198712e-03  1.811448e-02  5.095274e-03
## PC.ae.C44.6_T4     1.633537e-03  5.988863e-03 -3.108884e-04 -3.811170e-03
## SM..OH..C14.1_T4   4.231129e-02  1.390833e-02  3.690612e-03  1.083393e-02
## SM..OH..C16.1_T4   2.029405e-02  7.406794e-03 -4.347228e-03 -8.082512e-03
## SM..OH..C22.1_T4   2.166997e-02 -5.818154e-03  5.879100e-02 -1.076471e-02
## SM..OH..C22.2_T4   3.762161e-02  6.756919e-03  3.086037e-02  2.333675e-02
## SM..OH..C24.1_T4  -4.824727e-03  8.765468e-04  2.642172e-03  4.468085e-03
## SM.C16.0_T4        3.118398e-02 -7.024760e-02  2.560135e-02 -7.890368e-03
## SM.C16.1_T4        5.922895e-02 -6.245483e-02  3.200607e-02  1.488804e-02
## SM.C18.0_T4        1.354725e-02 -5.630575e-02 -6.798019e-02 -2.121373e-02
## SM.C18.1_T4        4.749996e-02 -5.452484e-02 -1.664905e-02 -3.437479e-03
## SM.C20.2_T4       -6.315210e-03  1.588522e-03 -1.886474e-03  3.572672e-03
## SM.C24.0_T4        2.042534e-02 -1.115038e-02  5.559609e-02  1.195155e-02
## SM.C24.1_T4        7.909938e-03 -5.400842e-02 -7.134715e-03 -1.175692e-02
## MEDDM_T5          -1.215140e-02  1.892288e-02 -3.713846e-03  1.173748e-02
## MEDCOL_T5         -1.215140e-02  1.892288e-02 -3.713846e-03  1.173748e-02
## MEDINF_T5         -1.024351e-02  5.471865e-03 -1.618744e-02  2.092101e-02
## MEDHTA_T5         -3.742653e-03  1.944652e-02 -8.403044e-03  1.144993e-02
## GLU_T5            -1.105012e-03  6.305845e-02 -4.705090e-02  2.030164e-02
## INS_T5             2.311529e-02 -1.783853e-02  3.730757e-02 -5.745260e-02
## HOMA_T5            8.139185e-03  9.690831e-04  1.085535e-02 -1.653347e-02
## HBA1C_T5          -2.982021e-02  2.207284e-02 -1.165776e-02  7.457689e-03
## HBA1C.mmol.mol_T5 -5.534167e-02  3.653455e-02 -3.134225e-02 -1.237305e-03
## PESO_T5           -1.817232e-02 -1.110993e-02  1.342098e-02  6.950555e-02
## bmi_T5             4.890168e-03  2.121263e-02  4.474003e-02  1.104184e-01
## CC_T5             -1.233951e-02  4.804718e-03 -4.954778e-04  3.110967e-03
## CINT_T5           -5.356064e-02  5.402418e-03  5.392996e-03  5.143261e-02
## CAD_T5             2.083178e-02  2.193120e-02  3.600915e-03  7.138528e-02
## TAD_T5             5.992323e-02  8.560809e-02  8.269473e-02  2.869023e-02
## TAS_T5             2.944324e-02  5.324271e-02  5.263534e-02  3.271713e-02
## TG_T5             -4.717724e-02  2.950024e-02 -1.883436e-02 -7.533243e-02
## COL_T5             1.430683e-02  4.252766e-02 -2.938254e-02 -3.616568e-02
## LDL_T5             1.714855e-02  3.789657e-02 -2.462774e-02 -9.887372e-03
## HDL_T5            -1.062221e-03  2.813056e-02 -1.603932e-02 -5.031757e-02
## VLDL_T5            5.987851e-03 -8.215912e-04 -1.856685e-02 -6.779953e-02
## PCR_T5            -1.650239e-02  5.461012e-02  6.661945e-02 -2.266853e-02
## LEP_T5             4.238692e-02  6.386480e-02  6.515016e-02 -2.185587e-02
## ADIPO_T5          -2.519766e-02 -3.980061e-02 -9.282826e-02  3.075407e-03
## GOT_T5            -2.448110e-03  1.391990e-02 -1.181854e-01  1.646274e-02
## GPT_T5            -4.018479e-02 -1.019588e-02 -6.806221e-02  1.026326e-01
## GGT_T5             2.161463e-02  1.888396e-02 -2.871833e-02 -1.335035e-03
## URICO_T5          -9.768863e-03  1.824812e-02 -1.615705e-02  2.845385e-03
## CREAT_T5          -3.451838e-03  6.670789e-03  1.313926e-03  3.035012e-03
## UREA_T5            3.352206e-02  3.464872e-03 -8.967631e-02 -7.332202e-03
## HIERRO_T5          1.067073e-01  1.567044e-01  3.471872e-03 -1.361022e-01
## TRANSF_T5         -7.245228e-02 -2.990592e-02 -5.825228e-02  1.148397e-02
## FERR_T5           -2.872008e-02  7.341960e-02  4.369494e-02 -5.849928e-02
## Ile_T5            -6.432331e-02 -9.845810e-02  4.098951e-03 -5.113138e-03
## Leu_T5            -1.403814e-02 -8.744255e-02  3.551757e-03 -2.428432e-02
## Val_T5             7.790214e-03 -5.304747e-02 -1.488802e-02 -4.205263e-03
## Ala_T5             1.899563e-02 -5.526083e-02  4.356429e-02 -5.344926e-02
## Pro_T5            -1.503003e-02 -4.487801e-03  2.713716e-02 -8.009313e-02
## Gly_T5            -3.729110e-02 -4.345035e-02 -3.080865e-02 -4.116782e-02
## Ser_T5            -5.395963e-02 -5.491676e-03 -6.311721e-02 -3.998163e-02
## Trp_T5             3.936330e-02 -5.985207e-02 -2.875734e-04  4.624235e-02
## Phe_T5             4.677485e-02 -5.685823e-02  1.565464e-02 -3.312902e-02
## Met_T5            -1.616842e-02 -5.262867e-02  5.239984e-02 -4.771190e-02
## Orn_T5            -2.997053e-02  1.000444e-04 -4.882588e-03  7.014798e-03
## Arg_T5             4.538897e-02 -2.707296e-02  2.587029e-02  5.464752e-02
## His_T5            -3.363089e-02 -5.977011e-03  3.833129e-02 -5.943247e-02
## Asn_T5            -2.219351e-02 -5.263356e-02  2.343692e-02 -2.100980e-02
## Asp_T5             2.316658e-02 -7.608379e-02 -8.197946e-02 -2.693028e-02
## Glu_T5             9.384528e-03 -4.537996e-04  2.113355e-02  7.318846e-03
## Gln_T5             3.939724e-03 -2.550476e-02  2.840303e-03  2.837727e-02
## Cit_T5             8.393797e-03 -5.780100e-02  6.112893e-02  6.693653e-02
## Tyr_T5             6.358557e-02 -3.101869e-02  2.743415e-02  3.236549e-02
## Thr_T5             4.611357e-02 -4.041097e-02  2.880014e-02  7.051668e-03
## Lys_T5            -1.322205e-02 -2.915154e-02 -1.863957e-02  6.309170e-03
## Creatinine_T5     -6.097603e-02 -6.075438e-02  1.074014e-03  6.575272e-02
## Kynurenine_T5      3.564197e-02 -3.829533e-02 -7.114218e-02  2.049746e-02
## Putrescine_T5      1.049769e-01  2.626105e-02  1.107551e-01  8.081849e-02
## Sarcosine_T5       3.171243e-02 -4.417270e-02 -2.204180e-03  7.980427e-02
## Serotonin_T5       2.828304e-02 -8.950605e-02 -7.971390e-03  5.175864e-02
## Taurine_T5         2.777413e-02 -1.840745e-03 -3.884006e-02  1.269154e-01
## SDMA_T5            3.295324e-03  4.765195e-03  1.060532e-03  8.285319e-03
## C0_T5             -5.129948e-03  2.687638e-02  1.566814e-02  6.273020e-02
## C2_T5             -1.399926e-02  3.684642e-02 -3.870773e-02  5.698967e-02
## C3.OH_T5          -8.185160e-03  2.287981e-03 -3.815484e-03  2.413609e-03
## C6..C4.1.DC._T5   -2.539170e-02  5.264564e-02  7.212189e-02  6.941495e-02
## C5.DC..C6.OH._T5   8.037170e-03 -4.335125e-02 -5.801437e-03  2.652536e-02
## C7.DC_T5          -6.864648e-02 -2.135950e-02  9.652906e-02  3.777382e-02
## C8_T5             -7.819134e-03  5.714559e-03 -2.060818e-03  2.918537e-03
## C10_T5            -1.783372e-03  9.576553e-03  1.480912e-03  3.162692e-03
## C10.1_T5           1.996965e-02 -9.972567e-03 -9.790865e-02 -4.026544e-03
## C10.2_T5          -6.468859e-03  4.203589e-03 -1.557475e-03  3.109347e-03
## C14.1_T5          -4.487179e-03  4.815074e-03 -7.424407e-05  3.491280e-03
## C14.2_T5          -6.114909e-03  4.378355e-03 -2.022769e-04  2.527573e-03
## C16.1_T5          -6.061560e-03  3.070626e-03 -1.014295e-03  3.104406e-03
## C16.2_T5          -5.834181e-03  4.175961e-03 -4.588976e-04  3.429980e-03
## C16.2.OH_T5       -9.009077e-02 -4.269014e-02 -9.499330e-02  1.088605e-02
## C18.1_T5          -5.042262e-03  4.332070e-03 -1.819053e-04  3.362380e-03
## C18.1.OH_T5       -5.533229e-03  4.192024e-03 -4.748739e-04  2.783911e-03
## C18.2_T5          -6.378266e-03  3.838254e-03 -4.259228e-04  3.456339e-03
## lysoPC.a.C16.0_T5 -3.873738e-02 -1.267373e-02  3.636362e-02  2.002333e-02
## lysoPC.a.C16.1_T5 -3.829708e-02 -3.255085e-02  3.019638e-02  1.018716e-02
## lysoPC.a.C17.0_T5  1.813623e-02  4.269653e-03  1.249543e-02  4.688479e-03
## lysoPC.a.C18.0_T5  2.519892e-02  4.294300e-03  6.018725e-02  1.564792e-02
## lysoPC.a.C18.1_T5 -3.352309e-02 -7.663331e-03  6.006357e-02  7.494720e-03
## lysoPC.a.C18.2_T5 -6.969217e-02  1.425284e-02  5.406400e-02  1.957501e-02
## lysoPC.a.C20.3_T5 -6.035783e-02 -1.120130e-02  1.248141e-02  2.121477e-03
## lysoPC.a.C20.4_T5 -1.390086e-01 -5.426873e-02  5.936057e-03  1.308377e-02
## lysoPC.a.C24.0_T5 -9.013414e-03  1.618317e-03 -1.914464e-03  5.110832e-03
## lysoPC.a.C26.0_T5 -8.604082e-03 -5.247227e-05 -6.533187e-04  1.271960e-03
## lysoPC.a.C26.1_T5 -1.212332e-02 -2.193522e-03 -1.586512e-03  2.009346e-03
## lysoPC.a.C28.0_T5 -9.389237e-02 -1.652437e-02 -4.007335e-02  2.500278e-02
## lysoPC.a.C28.1_T5 -9.621449e-03  3.591146e-03 -6.980944e-04  3.059061e-03
## PC.aa.C24.0_T5     7.412056e-02 -8.533977e-02 -9.176177e-02  6.572837e-02
## PC.aa.C28.1_T5    -3.021375e-05 -7.942036e-03 -5.581699e-03 -5.942852e-04
## PC.aa.C30.0_T5     6.823444e-03  1.034953e-02  1.382321e-02 -2.785525e-02
## PC.aa.C32.0_T5     9.272560e-03  2.793733e-02  7.116401e-03 -3.780354e-02
## PC.aa.C32.1_T5     1.032250e-02  6.585482e-03  3.863071e-02 -8.221348e-02
## PC.aa.C32.3_T5    -5.348563e-03  3.927045e-03 -1.237436e-03  2.320950e-03
## PC.aa.C34.1_T5     1.631738e-02  1.650260e-02 -4.742566e-03 -1.698106e-02
## PC.aa.C34.2_T5     2.900727e-02  4.888776e-02  2.756644e-02 -3.366856e-02
## PC.aa.C34.3_T5     2.768041e-02 -1.009231e-02 -6.720290e-03 -3.898531e-02
## PC.aa.C34.4_T5    -5.515969e-03  3.121036e-03 -1.070423e-03 -8.622692e-04
## PC.aa.C36.0_T5     1.403007e-02  1.343016e-03 -5.244533e-03 -4.124545e-03
## PC.aa.C36.1_T5     7.514059e-02  1.639929e-02  3.068525e-02  4.511941e-02
## PC.aa.C36.2_T5     7.088417e-02  3.404170e-02  3.572179e-02  6.064015e-04
## PC.aa.C36.3_T5     2.877815e-02  2.317888e-02 -7.970238e-03 -1.922684e-02
## PC.aa.C36.4_T5    -8.531380e-02 -3.443551e-02 -3.449996e-02  1.348940e-02
## PC.aa.C36.5_T5     3.016534e-02 -5.162969e-02  8.101686e-03 -5.365024e-02
## PC.aa.C38.0_T5     3.152916e-02 -7.652392e-03  4.823872e-03 -2.046743e-03
## PC.aa.C38.1_T5    -1.300652e-03  9.983090e-03 -1.157302e-02  4.707218e-03
## PC.aa.C38.3_T5     2.084485e-02 -1.286731e-03  6.398425e-03 -3.369665e-02
## PC.aa.C38.4_T5    -6.371574e-02 -2.953303e-02 -4.145715e-02  1.427516e-02
## PC.aa.C38.5_T5    -5.847056e-02 -4.283536e-02 -7.248366e-02 -2.696453e-03
## PC.aa.C38.6_T5     2.505914e-02 -4.025805e-02 -5.427639e-03 -1.480731e-03
## PC.aa.C40.1_T5    -1.431560e-02  4.613106e-02 -5.358810e-02  1.780685e-02
## PC.aa.C40.2_T5    -3.053985e-03 -6.410837e-06  1.219572e-03  1.843365e-03
## PC.aa.C40.3_T5    -6.582579e-03 -1.159644e-03 -1.346880e-03 -4.034917e-03
## PC.aa.C40.4_T5    -2.000199e-02 -3.906552e-03 -1.439995e-02 -1.733878e-02
## PC.aa.C40.5_T5    -2.767040e-02 -2.662283e-02 -2.307393e-02 -1.698011e-02
## PC.aa.C40.6_T5     9.338937e-03 -6.016125e-02  1.067868e-02 -1.528508e-02
## PC.aa.C42.0_T5    -1.892685e-03  3.082203e-03 -2.516186e-03 -2.762301e-03
## PC.aa.C42.1_T5    -4.384102e-03  3.577044e-03 -1.047590e-03  5.908845e-04
## PC.aa.C42.2_T5    -3.614694e-03  1.261895e-03 -2.016438e-04 -4.681893e-05
## PC.aa.C42.4_T5    -6.558825e-03  1.928285e-03 -1.543899e-03 -4.299503e-04
## PC.aa.C42.5_T5    -6.279784e-03  5.964528e-04 -2.905200e-03 -1.099878e-03
## PC.aa.C42.6_T5     1.787565e-02 -8.701089e-02 -7.682071e-02 -7.274189e-03
## PC.ae.C30.0_T5     1.887365e-02 -3.651824e-02 -5.833333e-02  2.271805e-03
## PC.ae.C32.1_T5     4.582441e-03  2.679035e-02 -1.138120e-03 -7.898968e-04
## PC.ae.C32.2_T5    -2.229861e-03  3.359177e-03 -3.393983e-03  3.597612e-03
## PC.ae.C34.0_T5    -1.050750e-03  5.655223e-03  1.198243e-05 -3.208524e-03
## PC.ae.C34.1_T5     5.799964e-02  1.636578e-02  2.454352e-02 -5.107226e-03
## PC.ae.C34.2_T5     5.498135e-02  5.875105e-02  2.595042e-03  1.988874e-02
## PC.ae.C34.3_T5     3.035519e-02  6.976189e-02 -2.198506e-03  1.523999e-02
## PC.ae.C36.0_T5     4.944732e-04  2.545093e-03  3.617524e-03  1.881442e-03
## PC.ae.C36.1_T5     4.446147e-02 -3.027289e-03 -5.544536e-04 -1.155167e-02
## PC.ae.C36.2_T5     7.878705e-02  3.654099e-02  1.087024e-02  2.739436e-03
## PC.ae.C36.3_T5     2.998245e-02  4.436523e-02  2.118648e-03  1.220342e-02
## PC.ae.C36.4_T5     2.768888e-02  2.310491e-02 -9.494884e-05  4.516457e-02
## PC.ae.C36.5_T5     5.805164e-03  3.130386e-02 -5.116751e-02  3.109121e-02
## PC.ae.C38.0_T5     2.992672e-03 -3.797577e-03 -1.095134e-03  1.182157e-03
## PC.ae.C38.2_T5     6.235138e-03 -3.101608e-03  7.646260e-03 -8.762313e-03
## PC.ae.C38.3_T5     1.409136e-02  3.016004e-03 -3.616922e-03  2.080159e-03
## PC.ae.C38.4_T5     2.257883e-02  1.808276e-02  2.651427e-03  3.044689e-03
## PC.ae.C38.5_T5     2.465686e-02 -2.224427e-02 -8.433865e-03  4.290491e-02
## PC.ae.C38.6_T5     1.823559e-02 -2.369599e-04 -1.421820e-02  3.224378e-02
## PC.ae.C40.1_T5    -6.062066e-03 -4.207754e-03 -7.103092e-03  1.067661e-02
## PC.ae.C40.2_T5     1.495444e-02 -9.340337e-03 -5.836347e-03 -6.487278e-03
## PC.ae.C40.3_T5     1.055723e-02  2.897995e-03 -3.760303e-03  7.175329e-04
## PC.ae.C40.4_T5     5.431572e-03  5.897197e-03  5.709263e-03 -1.004195e-02
## PC.ae.C40.5_T5     1.147169e-03 -5.932811e-03 -9.399763e-03  5.643133e-03
## PC.ae.C40.6_T5     1.865545e-02 -7.024796e-03 -7.460783e-03  4.931803e-03
## PC.ae.C42.1_T5    -7.160504e-03  7.010356e-04 -1.127678e-03  2.302273e-03
## PC.ae.C42.2_T5    -4.714585e-03  2.596480e-03 -2.220277e-03  2.844605e-03
## PC.ae.C42.3_T5    -1.067570e-03  4.420974e-03  2.848160e-03  2.488997e-03
## PC.ae.C42.4_T5    -2.459294e-03  6.652095e-03  3.177797e-03 -1.480182e-03
## PC.ae.C42.5_T5     2.726002e-03  4.451191e-03  6.000405e-03 -1.254294e-02
## PC.ae.C44.3_T5    -4.167404e-03  3.467226e-03 -7.311345e-04  1.155251e-03
## PC.ae.C44.4_T5    -3.205895e-03  7.818614e-03 -1.983892e-03 -5.643425e-04
## PC.ae.C44.5_T5    -5.797146e-03 -2.964582e-03  3.570962e-03 -1.008328e-04
## PC.ae.C44.6_T5    -1.366006e-02  4.769439e-03 -3.828909e-03 -4.180973e-03
## SM..OH..C14.1_T5   3.496955e-02  9.518628e-03 -2.781957e-02  6.342583e-03
## SM..OH..C16.1_T5   8.917218e-03  6.298961e-03 -9.878243e-03  2.909236e-03
## SM..OH..C22.1_T5   5.226469e-02  2.877245e-02  4.600481e-02 -1.965507e-02
## SM..OH..C22.2_T5   2.818473e-02  2.190884e-02  2.388689e-02 -8.266062e-03
## SM..OH..C24.1_T5  -5.870362e-03  6.001159e-03  3.661400e-03  1.247500e-03
## SM.C16.0_T5       -9.074720e-03 -6.234250e-03 -4.074202e-02  9.402622e-03
## SM.C16.1_T5       -2.062436e-02 -2.701496e-02 -2.036069e-02  9.722972e-02
## SM.C18.0_T5       -3.565447e-02  1.192970e-02 -6.371519e-02 -6.285627e-03
## SM.C18.1_T5       -5.534570e-02  1.813187e-02 -3.617685e-02  1.969706e-02
## SM.C20.2_T5       -8.726744e-03  3.942740e-03  3.411247e-04  1.871840e-03
## SM.C24.0_T5        4.271421e-02  3.158936e-03  6.182170e-02 -3.598210e-02
## SM.C24.1_T5       -3.069986e-02 -6.552131e-04 -4.247792e-02 -2.974281e-02
##                            PC25          PC26          PC27          PC28
## GLU_T0            -3.330054e-02  3.809685e-02 -5.984541e-03 -3.993760e-02
## INS_T0             4.845736e-02  3.918137e-02 -7.349649e-03  1.312606e-02
## HOMA_T0            2.657087e-02  2.609894e-02 -9.720048e-03 -5.593836e-03
## HBA1C_T0           7.925780e-03  2.225520e-03  2.287503e-04  2.099946e-03
## HBA1C.mmol.mol_T0  2.211683e-02  3.310134e-02  1.859428e-02  1.500561e-02
## PESO_T0           -3.366372e-03 -2.222508e-02 -1.148339e-02 -3.624408e-02
## bmi_T0             2.850679e-02  6.437569e-03  5.353911e-02 -9.553134e-03
## CC_T0             -2.031878e-03  1.135222e-03  2.148525e-03 -5.967980e-03
## CINT_T0           -9.995999e-03 -3.918056e-03  1.009256e-02 -5.026496e-02
## CAD_T0             3.062469e-03 -6.669389e-02 -5.635790e-03  4.681426e-03
## TAD_T0             1.835299e-03 -6.806184e-02  1.540754e-02  2.619026e-02
## TAS_T0             1.873608e-02 -3.735233e-02 -6.545144e-03  4.413566e-02
## TG_T0             -1.864583e-02 -1.512732e-02  5.442141e-02 -2.235447e-02
## COL_T0             8.942922e-02 -4.662701e-02  5.411291e-03  3.240192e-03
## LDL_T0             7.646534e-02 -6.012967e-02  2.614230e-02  1.144671e-02
## HDL_T0             4.986223e-02 -1.848923e-02  3.392558e-03  7.460098e-02
## VLDL_T0           -1.866767e-02 -1.608761e-02  5.540571e-02 -2.279264e-02
## PCR_T0            -1.822117e-02  8.651302e-02  1.710767e-01  1.377245e-01
## LEP_T0            -3.104812e-02 -1.978473e-03 -8.976349e-03 -5.305803e-02
## ADIPO_T0          -7.942763e-02 -4.593602e-02 -3.295254e-02  6.599733e-02
## GOT_T0             1.846781e-02 -1.642873e-02  1.202688e-02 -4.154410e-02
## GPT_T0            -4.416726e-02 -3.119580e-02 -7.318923e-02 -2.557512e-02
## GGT_T0            -9.718381e-02 -1.066398e-01  3.894927e-02  3.678129e-02
## URICO_T0          -1.679055e-02  2.774808e-03  2.814160e-02 -9.094829e-03
## CREAT_T0          -8.546869e-03 -9.927954e-03 -3.387069e-03 -4.283873e-03
## UREA_T0            7.286605e-02  7.420884e-03 -1.831310e-02 -5.237735e-02
## HIERRO_T0         -9.845866e-02 -6.588482e-02 -7.737152e-02 -1.222320e-03
## TRANSF_T0          2.503537e-02 -1.591491e-02  4.917946e-02 -9.232554e-02
## FERR_T0            5.969186e-02 -5.105256e-03  1.110999e-01  7.464203e-02
## Ile_T0             3.888989e-02 -1.279594e-02 -1.033675e-02 -8.097743e-03
## Leu_T0             4.355098e-02 -5.213360e-02 -2.113348e-02  1.867682e-02
## Val_T0             3.640352e-02  3.121451e-02  5.261240e-03  6.493416e-02
## Ala_T0            -2.350146e-02 -4.088889e-02  1.058294e-02  8.918158e-02
## Pro_T0            -3.497489e-02 -1.443069e-02 -3.943538e-02 -6.967149e-02
## Gly_T0            -1.553461e-01  4.658208e-02 -7.048778e-02 -3.682505e-02
## Ser_T0            -9.636958e-02  8.945607e-02 -9.808661e-02  1.006051e-01
## Trp_T0            -9.353378e-02 -2.741809e-02 -5.671870e-02  6.246888e-02
## Phe_T0            -2.103098e-02  7.107888e-03 -2.592687e-04  1.380308e-03
## Met_T0            -2.776063e-02 -2.648523e-02 -4.542412e-02  2.451612e-03
## Orn_T0             9.782356e-02  2.319961e-02  1.482175e-02 -7.467745e-02
## Arg_T0            -2.369518e-02  1.918694e-03  1.309650e-02 -6.402030e-02
## His_T0            -7.523202e-02  1.025048e-02 -5.418427e-02 -3.292692e-02
## Asn_T0            -8.069119e-02 -2.504625e-02 -4.917429e-02 -6.184984e-02
## Asp_T0            -2.016592e-03  4.370644e-02 -3.743410e-02  1.730055e-02
## Glu_T0            -2.147228e-02  1.592260e-02  4.553922e-03  3.391945e-02
## Gln_T0            -5.267490e-02  3.392320e-02 -4.507679e-02 -4.522152e-02
## Cit_T0            -2.410307e-02  4.633545e-02 -5.597435e-02 -1.121199e-01
## Tyr_T0            -3.462433e-03 -3.039762e-02  6.714476e-02 -2.955029e-02
## Thr_T0             4.963024e-02  1.830474e-02 -9.501448e-02 -3.041556e-02
## Lys_T0            -9.671786e-03 -2.851258e-02  3.521468e-02 -3.462360e-02
## Creatinine_T0     -1.445012e-01 -2.816963e-02 -8.940134e-03 -3.663187e-02
## Kynurenine_T0     -3.412793e-02  1.478782e-02  2.260526e-02  1.357466e-02
## Putrescine_T0     -3.661601e-02  2.462366e-01 -8.144857e-02  4.324627e-02
## Sarcosine_T0       2.914719e-02  3.819487e-02  4.334260e-02 -1.941869e-02
## Serotonin_T0      -1.355130e-01  5.443486e-03  1.045855e-01  1.982184e-01
## Taurine_T0         9.729396e-02  1.345444e-01 -1.202688e-01  2.562568e-02
## SDMA_T0           -1.058463e-02 -6.091790e-03 -1.807065e-03 -7.336744e-03
## C0_T0             -6.865593e-02  2.895294e-02  5.696480e-02  2.200393e-02
## C2_T0             -1.876082e-02 -7.247281e-02 -1.766367e-02 -2.032418e-02
## C3.OH_T0           8.934073e-04 -3.957710e-03 -9.741250e-04 -1.394909e-03
## C6..C4.1.DC._T0    7.094878e-03  1.365737e-02  4.642873e-02  8.072364e-02
## C5.DC..C6.OH._T0   1.063392e-01  1.259778e-01  3.184775e-02 -7.288365e-03
## C7.DC_T0           1.211704e-01  1.164593e-01  1.287695e-02 -2.836254e-02
## C8_T0              4.413582e-03  1.086296e-03  5.205319e-03 -3.425584e-03
## C10_T0             1.333799e-03 -1.162068e-02  2.382208e-03 -4.615143e-03
## C10.1_T0           2.422591e-03 -8.596753e-03  4.144417e-03 -1.766763e-03
## C10.2_T0           1.409969e-03 -4.396764e-03  2.982493e-03 -8.290319e-04
## C14.1_T0           5.049174e-05 -6.327317e-03  3.017323e-03 -3.725295e-03
## C14.2_T0           1.175555e-03 -5.371601e-03  2.721009e-03 -2.443442e-03
## C16.1_T0           1.107711e-03 -3.959504e-03  2.289520e-03 -2.178135e-03
## C16.2_T0           3.866039e-04 -5.003172e-03  2.687751e-03 -2.250161e-03
## C16.2.OH_T0        7.658804e-04 -5.002360e-03  2.562434e-03 -1.609395e-03
## C18.1_T0          -9.617001e-04 -4.615310e-03  3.873796e-03 -1.922777e-03
## C18.1.OH_T0        4.989377e-04 -5.075618e-03  2.426532e-03 -1.484552e-03
## C18.2_T0          -2.343982e-05 -4.721157e-03  3.129958e-03 -3.120903e-03
## lysoPC.a.C16.0_T0 -1.870301e-02  3.512434e-02 -4.592251e-02  6.317796e-03
## lysoPC.a.C16.1_T0 -1.845907e-03  1.253718e-02 -1.473056e-02  5.655034e-03
## lysoPC.a.C17.0_T0 -5.328167e-03 -1.175649e-02 -2.295085e-02 -2.126710e-03
## lysoPC.a.C18.0_T0 -8.469935e-03  2.961744e-02 -3.531389e-02 -6.344503e-04
## lysoPC.a.C18.1_T0 -4.198487e-02  1.059321e-02 -4.451378e-02  3.747749e-02
## lysoPC.a.C18.2_T0 -2.700846e-03  1.343363e-02 -6.794170e-02  3.422970e-02
## lysoPC.a.C20.3_T0  2.240033e-02 -1.443432e-02 -2.203777e-02  2.278857e-03
## lysoPC.a.C20.4_T0 -1.242449e-02 -3.301955e-02 -6.107513e-02  2.083692e-02
## lysoPC.a.C24.0_T0  5.069645e-03 -4.588508e-03 -4.381027e-04  4.569009e-04
## lysoPC.a.C26.0_T0 -5.217926e-02 -1.104135e-02 -3.125919e-02  2.632270e-02
## lysoPC.a.C26.1_T0 -1.365466e-03 -1.165172e-03 -1.519471e-03  2.352402e-03
## lysoPC.a.C28.0_T0  5.927951e-02  4.440307e-02 -8.144027e-03  3.673299e-02
## lysoPC.a.C28.1_T0  2.181103e-03 -1.939573e-03  2.882247e-03 -1.040130e-04
## PC.aa.C24.0_T0    -1.513975e-02 -4.692310e-02 -6.309735e-02  1.054152e-01
## PC.aa.C28.1_T0     2.942373e-02  5.112064e-03 -2.360315e-02 -1.526898e-02
## PC.aa.C30.0_T0     4.061275e-02  3.108154e-02 -2.692304e-02 -1.282818e-02
## PC.aa.C32.0_T0     4.492813e-03  5.545250e-02 -6.505378e-02 -5.699927e-03
## PC.aa.C32.1_T0     3.342163e-02  2.083617e-02  8.775351e-03 -1.208507e-02
## PC.aa.C32.3_T0     1.480180e-03 -4.124255e-03  2.872014e-03 -4.412433e-04
## PC.aa.C34.1_T0    -5.808964e-02 -1.563675e-02 -1.061359e-02  2.333182e-02
## PC.aa.C34.2_T0     1.436220e-02  8.398923e-03  2.274165e-03 -1.645876e-02
## PC.aa.C34.3_T0     2.110576e-02  2.382366e-02  5.674041e-03  1.595010e-03
## PC.aa.C34.4_T0     2.100460e-02  4.796933e-03 -5.396030e-03 -6.313318e-03
## PC.aa.C36.0_T0     4.743830e-03 -2.076239e-03  1.588252e-02  1.150201e-02
## PC.aa.C36.1_T0     4.192878e-03 -8.655264e-03  1.092506e-02 -7.219185e-03
## PC.aa.C36.2_T0     1.708872e-02  6.357398e-03  3.012547e-02 -2.905896e-02
## PC.aa.C36.3_T0    -1.491128e-02  2.087706e-02 -3.972879e-03 -3.247733e-02
## PC.aa.C36.4_T0    -2.808845e-02 -9.020701e-03 -4.243885e-02 -2.279725e-02
## PC.aa.C36.5_T0     4.519894e-03 -5.421899e-02 -2.089515e-02  1.958969e-02
## PC.aa.C38.0_T0     4.111184e-03  2.761207e-02 -8.255482e-03  4.794942e-02
## PC.aa.C38.1_T0    -3.258459e-02 -1.002271e-02  2.496111e-02  3.620296e-02
## PC.aa.C38.3_T0     1.021853e-02  4.669903e-03 -2.002377e-03 -1.546600e-02
## PC.aa.C38.4_T0    -3.104154e-02 -4.196877e-02 -2.067803e-02 -4.024057e-02
## PC.aa.C38.5_T0    -1.841474e-02 -5.399198e-02 -6.547889e-02 -2.717177e-02
## PC.aa.C38.6_T0    -5.467285e-02 -1.107600e-01 -8.499544e-02  3.308588e-02
## PC.aa.C40.1_T0     1.651679e-02 -3.315109e-02 -8.073915e-03  2.240687e-02
## PC.aa.C40.2_T0     4.605046e-03  6.181711e-03  1.539797e-02 -1.834220e-03
## PC.aa.C40.3_T0     3.138362e-03  1.247876e-03  1.524201e-02  1.204366e-03
## PC.aa.C40.4_T0     1.628764e-02  1.815537e-03  1.398212e-02 -2.671448e-02
## PC.aa.C40.5_T0     1.988256e-02 -1.882302e-02  2.354005e-02 -4.412979e-02
## PC.aa.C40.6_T0    -6.379228e-03 -9.945029e-02 -4.576195e-02  5.678932e-02
## PC.aa.C42.0_T0     1.975904e-03  2.193840e-03 -1.247909e-03  4.132466e-03
## PC.aa.C42.1_T0     2.127755e-03 -8.979214e-04  4.511503e-03  3.259690e-03
## PC.aa.C42.2_T0     2.073819e-03  2.233701e-03  9.120718e-03  2.492344e-03
## PC.aa.C42.4_T0     3.489023e-03  2.673122e-03  8.552888e-03  1.650155e-03
## PC.aa.C42.5_T0    -8.698651e-04 -2.165399e-03  6.494679e-03 -1.463061e-03
## PC.aa.C42.6_T0    -3.656740e-02 -3.595061e-02 -1.113042e-01  9.891552e-02
## PC.ae.C30.0_T0     4.361420e-03 -4.268271e-03  9.307923e-04 -6.630248e-04
## PC.ae.C32.1_T0     8.428638e-03  4.069566e-03 -1.763825e-02  3.389163e-03
## PC.ae.C32.2_T0    -9.036987e-05 -2.376690e-03 -2.446197e-03  1.694265e-03
## PC.ae.C34.0_T0     2.091888e-03 -4.031750e-03  3.882454e-03  2.583615e-03
## PC.ae.C34.1_T0    -1.436590e-02  6.716330e-03 -1.376056e-02  2.362471e-02
## PC.ae.C34.2_T0    -7.044878e-03  3.239347e-02 -9.283667e-03  2.487518e-02
## PC.ae.C34.3_T0     4.579224e-03 -1.257199e-02  2.503348e-02  4.864475e-04
## PC.ae.C36.0_T0    -5.001608e-03 -8.934826e-04  9.387882e-03  3.438685e-03
## PC.ae.C36.1_T0     3.424320e-03  1.659465e-03  2.479726e-02  3.904239e-03
## PC.ae.C36.2_T0     8.980820e-03 -1.105245e-02  9.893605e-03  1.191535e-02
## PC.ae.C36.3_T0    -2.692045e-02  2.660190e-02  2.003209e-04  2.137064e-02
## PC.ae.C36.4_T0    -2.297885e-02  7.366323e-02  1.605332e-02  2.567313e-02
## PC.ae.C36.5_T0     1.257403e-02 -6.861069e-03  1.974356e-02 -2.059912e-03
## PC.ae.C38.0_T0     8.322461e-04 -1.064627e-02  2.965298e-04  5.979182e-03
## PC.ae.C38.2_T0     1.288090e-02  1.864372e-02  2.850289e-02 -9.005732e-04
## PC.ae.C38.3_T0     2.071864e-03 -2.082762e-03  1.313521e-02  1.040205e-02
## PC.ae.C38.4_T0    -1.529690e-02 -1.348010e-03 -1.036695e-02  4.749441e-03
## PC.ae.C38.5_T0    -4.944449e-02  7.229523e-02 -1.899714e-02  5.327872e-02
## PC.ae.C38.6_T0     4.382384e-03  2.154078e-02 -2.081345e-02  2.281552e-02
## PC.ae.C40.1_T0     7.608788e-03  5.239730e-03  6.240455e-03  7.949047e-03
## PC.ae.C40.2_T0     9.562458e-03 -1.583930e-03  1.540024e-02  4.228771e-03
## PC.ae.C40.3_T0     6.331691e-03  3.914821e-03  1.367756e-02  7.911060e-03
## PC.ae.C40.4_T0     6.799696e-03  1.650369e-02  1.571506e-02  1.028256e-02
## PC.ae.C40.5_T0     5.587116e-03  1.633641e-02  1.077752e-02  8.605029e-03
## PC.ae.C40.6_T0    -1.517744e-03 -8.106331e-03 -2.548882e-02  1.862299e-02
## PC.ae.C42.1_T0     1.746463e-03  1.579200e-03  1.104234e-02  1.409377e-03
## PC.ae.C42.2_T0     3.982469e-03 -7.635549e-04  9.864865e-03  9.236661e-04
## PC.ae.C42.3_T0     7.482663e-03  1.789302e-03  1.102160e-02  2.302031e-03
## PC.ae.C42.4_T0     7.888267e-03  8.034372e-03  7.582853e-03 -1.912100e-04
## PC.ae.C42.5_T0     4.099723e-03  2.231904e-02 -3.976034e-03  1.299555e-02
## PC.ae.C44.3_T0     7.499331e-04 -1.865707e-04  6.727290e-03 -7.154628e-04
## PC.ae.C44.4_T0     2.535591e-03 -5.670317e-04  3.733760e-03  1.322408e-03
## PC.ae.C44.5_T0     2.072903e-04  1.308042e-02 -1.190590e-02  1.861736e-02
## PC.ae.C44.6_T0    -6.771930e-04  4.451195e-03 -8.436449e-03  1.028663e-02
## SM..OH..C14.1_T0   4.935202e-02  3.305772e-03 -1.755801e-02 -2.270471e-04
## SM..OH..C16.1_T0   1.038489e-02 -1.090486e-02 -5.374343e-03 -1.851818e-03
## SM..OH..C22.1_T0   4.949688e-02 -1.953625e-02  4.786934e-02 -2.299655e-02
## SM..OH..C22.2_T0   3.493459e-02  2.336677e-02  1.839277e-02  3.240324e-03
## SM..OH..C24.1_T0   3.643929e-03 -6.949653e-03 -9.435219e-04 -4.215584e-03
## SM.C16.0_T0        4.252676e-02  5.977779e-02 -3.214053e-02  3.056961e-02
## SM.C16.1_T0        1.178434e-02  3.428425e-02 -5.861956e-02  1.510777e-02
## SM.C18.0_T0        4.753968e-02  3.226785e-03 -4.484791e-02  1.845132e-02
## SM.C18.1_T0       -2.804140e-04 -1.466128e-02 -4.112668e-02  1.229994e-02
## SM.C20.2_T0        5.114063e-03 -9.438369e-04  1.446218e-03 -2.479887e-03
## SM.C24.0_T0        5.402258e-02 -9.818250e-03  4.902267e-02  2.082081e-03
## SM.C24.1_T0        1.097507e-02  5.687388e-02 -1.456455e-02  3.542257e-02
## MEDDM_T2           6.998534e-04 -4.836481e-03  3.235408e-03 -1.523158e-03
## MEDCOL_T2          6.998534e-04 -4.836481e-03  3.235408e-03 -1.523158e-03
## MEDINF_T2          1.394490e-02  2.103480e-04  1.348739e-02 -2.116349e-02
## MEDHTA_T2          2.368225e-03 -4.087830e-03  9.559456e-03  2.144600e-03
## GLU_T2             4.162062e-04  3.768484e-02 -5.173236e-02  5.507467e-02
## INS_T2            -5.090253e-05 -2.204381e-04 -1.695279e-01  3.650285e-02
## HOMA_T2            3.508930e-03  7.909645e-03 -1.075929e-01  2.906683e-02
## HBA1C_T2           5.689852e-03 -4.401258e-03 -1.856358e-02 -1.850236e-03
## HBA1C.mmol.mol_T2  2.094425e-02  1.696108e-02 -4.943232e-02  4.053430e-03
## PESO_T2           -1.202393e-02 -1.816431e-03 -3.082973e-02 -5.378427e-02
## bmi_T2             2.059910e-02  4.284446e-02  5.330095e-02 -3.066399e-02
## CC_T2             -1.419569e-03 -5.303957e-03 -3.802548e-04 -7.995151e-03
## CINT_T2           -3.233283e-03  1.724534e-02 -4.533327e-02 -8.378264e-02
## CAD_T2             1.967395e-02 -4.076300e-04 -2.660120e-02 -1.912732e-02
## TAD_T2            -1.430830e-02  1.151383e-02  6.497055e-02 -3.974195e-02
## TAS_T2             3.032212e-02 -2.667577e-02  3.848225e-02  1.184886e-02
## TG_T2             -1.622393e-03 -3.389280e-02 -9.138060e-02 -8.773202e-03
## COL_T2            -5.692757e-03  3.395374e-02 -1.272024e-03  2.418753e-02
## LDL_T2            -1.774196e-02  6.710270e-02  3.703686e-02  4.382402e-02
## HDL_T2            -1.974047e-02 -2.798570e-02 -5.138166e-02  4.607126e-02
## VLDL_T2           -3.777867e-02  1.005763e-02 -5.875104e-02  5.399645e-02
## PCR_T2            -2.691619e-02  1.193408e-01  8.454947e-02  1.812146e-01
## LEP_T2             1.003336e-03 -6.464399e-03 -5.423093e-02 -2.933910e-02
## ADIPO_T2          -2.962755e-02 -5.789072e-02  4.103032e-03  6.900283e-03
## GOT_T2            -1.348351e-02 -1.520924e-03  4.951287e-02 -1.645674e-01
## GPT_T2            -5.400541e-03  6.253057e-03  7.650758e-03 -3.211812e-02
## GGT_T2            -5.698567e-02 -1.388399e-01  4.971686e-02  9.377692e-03
## URICO_T2           5.922603e-02 -6.496633e-02 -9.312060e-03  3.787208e-02
## CREAT_T2          -2.983144e-03 -1.032551e-02 -5.117270e-05 -1.373610e-03
## UREA_T2            1.012490e-01  4.299118e-02 -3.553496e-02 -2.554139e-02
## HIERRO_T2         -1.148357e-01 -4.558793e-02 -4.215030e-03 -1.032257e-01
## TRANSF_T2         -4.039948e-02  2.561546e-02  2.452554e-02 -1.129316e-01
## FERR_T2            5.672556e-02  2.962909e-02  1.070536e-01  9.831528e-02
## Ile_T2            -9.277706e-03 -3.514753e-02 -2.090282e-03  1.556115e-02
## Leu_T2            -2.515499e-02 -4.751944e-03 -2.293138e-02  1.606344e-02
## Val_T2            -3.773886e-03  3.823318e-02 -3.534470e-02 -2.400145e-03
## Ala_T2            -1.944525e-03 -9.604644e-02 -9.411155e-02  4.474848e-02
## Pro_T2             5.627874e-02 -1.138931e-01 -9.639464e-02 -4.540719e-02
## Gly_T2            -6.124116e-03 -3.328652e-02 -5.763656e-02  2.661025e-02
## Ser_T2             2.042361e-02  1.332197e-02  1.744942e-02  1.339566e-01
## Trp_T2            -1.013802e-01  9.298686e-02  4.139280e-02 -1.402729e-02
## Phe_T2            -1.279818e-03 -1.717475e-02 -2.034441e-02  8.390415e-02
## Met_T2             6.683424e-02 -2.213170e-02  6.330154e-02  7.032882e-02
## Orn_T2             3.548677e-02  2.156503e-02 -1.427909e-02 -2.393250e-02
## Arg_T2             1.909496e-02 -8.069319e-03  4.658211e-02 -1.349586e-02
## His_T2             3.118064e-02 -9.614713e-03 -5.366835e-02 -2.761082e-03
## Asn_T2             3.265797e-02 -7.192697e-02 -4.223948e-02 -3.200968e-02
## Asp_T2            -2.971175e-02 -3.830532e-03  1.575607e-02  1.021018e-01
## Glu_T2            -3.085381e-02 -3.769164e-02 -2.887519e-02  4.030868e-02
## Gln_T2             7.800338e-02 -3.629995e-02 -2.719242e-03 -3.290286e-02
## Cit_T2            -2.031636e-02  2.810881e-02 -8.416384e-04 -4.709511e-02
## Tyr_T2            -1.251962e-02  9.146484e-03 -1.668865e-02 -3.500278e-03
## Thr_T2             6.507257e-02  4.436037e-02 -1.537285e-02  4.561494e-02
## Lys_T2             4.902485e-02 -5.835242e-02 -5.007756e-02 -2.434442e-02
## Creatinine_T2      1.094159e-02 -1.799225e-02 -2.907651e-02  6.644879e-02
## Kynurenine_T2     -5.309466e-03  1.908021e-02  2.959299e-02 -1.340452e-02
## Putrescine_T2      1.591330e-01 -4.163553e-03 -3.855072e-02 -8.753355e-02
## Sarcosine_T2       7.789150e-02 -8.442334e-02 -1.616977e-02  2.017387e-02
## Serotonin_T2      -5.781388e-02  1.954975e-02 -5.831070e-02 -6.417695e-02
## Taurine_T2         1.773786e-02  1.633644e-02  1.034508e-02 -3.843011e-03
## SDMA_T2           -4.518724e-03 -1.301404e-02  2.118971e-02  1.917940e-02
## C0_T2             -1.505898e-02  1.123809e-02 -1.327228e-02 -6.845577e-04
## C2_T2              9.496882e-02 -4.432794e-02 -2.722596e-02  5.017186e-02
## C3.OH_T2          -1.555335e-03 -3.075115e-03  5.953722e-03  5.882872e-04
## C6..C4.1.DC._T2    2.438482e-03  1.259964e-01  1.406865e-02 -7.629619e-02
## C5.DC..C6.OH._T2   4.568371e-04 -3.459540e-02  7.660597e-02  2.052815e-02
## C7.DC_T2          -5.015267e-02  8.898420e-02  9.115935e-02  1.214092e-02
## C8_T2             -2.397523e-03 -8.678811e-03  2.895251e-03  5.564288e-03
## C10_T2            -3.210234e-03 -9.246425e-03 -1.304516e-05  6.905900e-03
## C10.1_T2          -1.580838e-03 -9.464917e-03  3.261271e-03  2.162673e-03
## C10.2_T2          -5.446424e-04 -4.050147e-03  4.043942e-03  2.085832e-03
## C14.1_T2           1.163385e-03 -6.944509e-03  4.054226e-03 -8.209696e-04
## C14.2_T2           2.233051e-05 -5.812067e-03  2.269188e-03  3.135194e-04
## C16.1_T2           5.594039e-04 -6.167057e-03  3.595101e-03 -1.324978e-04
## C16.2_T2           5.646758e-04 -4.415496e-03  3.171602e-03 -1.307753e-03
## C16.2.OH_T2        4.407068e-04 -4.679345e-03  3.255912e-03 -9.166691e-04
## C18.1_T2           3.266645e-03 -7.203968e-03  5.622545e-03  1.198231e-03
## C18.1.OH_T2        3.463694e-04 -4.744781e-03  3.008169e-03 -6.917152e-04
## C18.2_T2           2.100470e-03 -6.853267e-03  4.145624e-03  1.738631e-03
## lysoPC.a.C14.0_T2 -7.865800e-03  6.986285e-02 -5.635120e-02 -1.024472e-01
## lysoPC.a.C16.0_T2 -1.776449e-02  7.564841e-02 -3.463363e-02 -6.406657e-02
## lysoPC.a.C16.1_T2 -1.344105e-02  2.978104e-02 -1.142903e-02 -1.465473e-02
## lysoPC.a.C17.0_T2 -2.101403e-02  6.864866e-03 -2.221256e-02 -2.421921e-02
## lysoPC.a.C18.0_T2 -5.463776e-02  5.913111e-02 -1.891964e-02 -4.778604e-02
## lysoPC.a.C18.1_T2 -3.718389e-02  6.551454e-02 -3.808418e-02 -2.452425e-02
## lysoPC.a.C18.2_T2 -7.540309e-02  2.401944e-02 -5.784078e-02 -2.407433e-02
## lysoPC.a.C20.3_T2  8.868036e-03 -2.105039e-04 -5.110575e-03  1.214995e-02
## lysoPC.a.C20.4_T2  5.242166e-02 -2.280628e-02 -6.068596e-02 -1.451184e-02
## lysoPC.a.C24.0_T2 -3.541675e-03 -4.868678e-03 -8.539904e-04 -3.753407e-03
## lysoPC.a.C26.0_T2 -1.165158e-02 -1.849652e-02  1.069871e-01 -1.121858e-01
## lysoPC.a.C26.1_T2  3.164357e-03 -8.268879e-03  7.857158e-03 -6.089077e-03
## lysoPC.a.C28.0_T2 -8.425902e-02 -4.918792e-02  4.281451e-02  8.725376e-02
## lysoPC.a.C28.1_T2 -3.101720e-03 -4.912896e-03 -9.086597e-04 -9.272758e-03
## PC.aa.C24.0_T2     6.615407e-02 -7.542048e-02  4.662428e-02  1.794969e-02
## PC.aa.C28.1_T2    -9.578932e-03  2.053343e-03 -2.201411e-03  5.932682e-03
## PC.aa.C30.0_T2     5.146175e-03 -1.202302e-02 -4.125162e-03  1.098094e-03
## PC.aa.C32.0_T2     3.703221e-02  1.900813e-02  5.253314e-02 -4.437209e-02
## PC.aa.C32.1_T2     1.071991e-02  5.155102e-02 -1.257806e-02 -3.132313e-02
## PC.aa.C32.3_T2     3.437940e-03 -5.912304e-03  4.991191e-03 -2.744278e-03
## PC.aa.C34.1_T2    -4.991508e-03  5.919593e-02  4.472964e-02 -2.306195e-02
## PC.aa.C34.2_T2     1.033764e-02  2.293205e-02  7.574617e-02  4.315617e-03
## PC.aa.C34.3_T2    -2.341333e-02  1.508502e-02  3.939269e-03 -2.000927e-02
## PC.aa.C34.4_T2    -1.687908e-04 -5.885663e-03  6.491171e-04 -1.966997e-03
## PC.aa.C36.0_T2    -8.781772e-03 -1.081215e-02 -1.032287e-02 -1.350850e-02
## PC.aa.C36.1_T2    -8.473033e-02  4.057865e-02  2.725674e-03  1.171940e-02
## PC.aa.C36.2_T2    -4.183608e-02  5.899868e-03  3.513874e-02 -1.111677e-02
## PC.aa.C36.3_T2    -2.013500e-02  2.941428e-02  2.163019e-02  4.435400e-02
## PC.aa.C36.4_T2     1.290916e-01 -5.467540e-02  3.772775e-02 -1.388765e-02
## PC.aa.C36.5_T2    -3.037296e-02  3.579817e-02 -5.172052e-02 -3.448212e-02
## PC.aa.C38.0_T2    -3.341014e-02  1.947930e-02 -1.233495e-02 -5.572661e-03
## PC.aa.C38.1_T2    -8.246032e-03  1.598314e-02 -5.169707e-02  9.891511e-03
## PC.aa.C38.3_T2     1.088045e-02  1.824627e-02  3.047354e-02  1.814052e-02
## PC.aa.C38.4_T2     8.701720e-02 -7.577204e-03  1.712621e-02 -7.029014e-02
## PC.aa.C38.5_T2     3.927457e-02  4.817727e-02  1.289335e-02 -7.130332e-02
## PC.aa.C38.6_T2     3.078560e-04  4.597543e-02  4.889243e-03 -3.090124e-02
## PC.aa.C40.1_T2    -4.888288e-02  2.466799e-02  2.781324e-02  2.460397e-02
## PC.aa.C40.2_T2    -1.546601e-02 -4.422479e-03 -1.737390e-02 -1.698561e-02
## PC.aa.C40.3_T2    -9.429098e-03 -2.660978e-03 -1.435469e-02 -1.699187e-02
## PC.aa.C40.4_T2     3.720933e-04  1.133868e-02 -4.481289e-03 -2.197799e-02
## PC.aa.C40.5_T2     7.677037e-03  3.281838e-02  4.469446e-03 -5.184969e-02
## PC.aa.C40.6_T2    -2.383667e-02  3.393701e-02 -1.296864e-02 -2.938792e-02
## PC.aa.C42.0_T2    -4.071051e-03 -3.172661e-03 -2.399154e-03 -9.541374e-03
## PC.aa.C42.1_T2    -2.922460e-03 -1.423440e-03 -1.793647e-03 -6.657031e-03
## PC.aa.C42.2_T2    -4.673693e-03 -4.492740e-04 -3.529342e-03 -8.659363e-03
## PC.aa.C42.4_T2    -1.432236e-03 -3.643751e-03 -1.031940e-03 -5.816925e-03
## PC.aa.C42.5_T2    -1.878761e-03 -2.253900e-03 -1.079197e-04 -7.182319e-03
## PC.aa.C42.6_T2    -2.800234e-02  5.293228e-02  5.899719e-02 -4.630914e-02
## PC.ae.C30.0_T2    -8.224521e-02 -3.404002e-02  5.036798e-02  3.159408e-02
## PC.ae.C32.1_T2    -7.279932e-03 -2.881711e-03  8.059367e-03 -1.721769e-03
## PC.ae.C32.2_T2    -1.541029e-03 -8.007441e-04  4.060182e-03 -5.944006e-03
## PC.ae.C34.0_T2    -2.071206e-03 -3.019915e-03  5.414778e-03  4.548138e-04
## PC.ae.C34.1_T2    -2.319864e-02  7.287006e-03  4.202390e-03  2.333605e-02
## PC.ae.C34.2_T2    -1.348874e-02  1.026655e-02  1.052127e-02  6.598739e-03
## PC.ae.C34.3_T2    -1.266869e-02 -2.521473e-02  1.551308e-02 -2.024701e-02
## PC.ae.C36.0_T2    -1.050255e-02  2.153468e-03  6.727401e-03 -6.666185e-03
## PC.ae.C36.1_T2    -5.081757e-02  5.112664e-03 -5.315768e-02 -3.790796e-02
## PC.ae.C36.2_T2    -3.522629e-02  2.422484e-04 -2.605162e-02 -3.562486e-03
## PC.ae.C36.3_T2    -9.165042e-03  7.182374e-03  8.823655e-03  1.146196e-02
## PC.ae.C36.4_T2    -3.158380e-03  1.199106e-02  2.357470e-02 -8.134691e-03
## PC.ae.C36.5_T2     1.697954e-02  8.548097e-03  1.976865e-02 -3.121207e-02
## PC.ae.C38.0_T2    -1.012734e-02  1.102249e-02 -1.334399e-03 -1.072611e-02
## PC.ae.C38.2_T2    -3.639771e-02  4.680880e-03 -4.619784e-02 -2.696280e-02
## PC.ae.C38.3_T2    -2.332690e-02 -5.058986e-03 -3.288476e-02 -2.045538e-02
## PC.ae.C38.4_T2    -4.654992e-03 -1.125958e-02 -7.223303e-03  2.708958e-02
## PC.ae.C38.5_T2    -1.797652e-03 -2.653740e-03  1.795799e-02 -8.813725e-03
## PC.ae.C38.6_T2     3.931314e-03  1.966757e-02  7.949014e-03 -1.460355e-02
## PC.ae.C40.1_T2    -1.745620e-02 -1.594973e-03 -1.282657e-02 -2.269313e-02
## PC.ae.C40.2_T2    -2.305664e-02 -4.695761e-03 -1.540794e-02 -8.529866e-04
## PC.ae.C40.3_T2    -2.152589e-02 -5.045298e-03 -2.334010e-02 -1.684616e-02
## PC.ae.C40.4_T2    -1.847106e-02  8.155691e-03 -7.144110e-03 -5.235712e-03
## PC.ae.C40.5_T2     6.397115e-03  1.793127e-03 -1.787770e-03 -1.154301e-02
## PC.ae.C40.6_T2    -5.680904e-03  1.166555e-03 -2.109518e-03  5.125290e-03
## PC.ae.C42.1_T2    -7.909593e-03 -7.146552e-03 -9.615536e-03 -1.556510e-02
## PC.ae.C42.2_T2    -1.194363e-02 -1.907025e-03 -8.541325e-03 -1.042020e-02
## PC.ae.C42.3_T2    -1.474416e-02 -1.584993e-03 -6.332825e-03 -1.255145e-02
## PC.ae.C42.4_T2    -7.025133e-03 -1.625929e-03 -2.702209e-03  5.677997e-03
## PC.ae.C42.5_T2    -5.001142e-03  6.188174e-04  2.071662e-04 -1.513416e-03
## PC.ae.C44.3_T2    -3.697745e-02 -8.366746e-03  2.186352e-02  3.920146e-02
## PC.ae.C44.4_T2    -3.069554e-03 -4.093503e-03 -1.042890e-03 -2.887303e-03
## PC.ae.C44.5_T2    -2.961117e-03 -1.179575e-02 -5.694363e-03 -7.892793e-03
## PC.ae.C44.6_T2    -4.674248e-03 -1.211823e-02  2.213640e-04 -4.215689e-03
## SM..OH..C14.1_T2   9.942621e-03 -9.932170e-03 -1.235504e-02  1.326694e-03
## SM..OH..C16.1_T2   4.626666e-03 -1.016903e-02 -6.696141e-03  4.300770e-03
## SM..OH..C22.1_T2  -1.904979e-02  7.464701e-03  2.658704e-03 -5.715427e-04
## SM..OH..C22.2_T2  -1.083230e-02 -7.005616e-03 -1.444536e-02  3.605460e-03
## SM..OH..C24.1_T2  -3.046617e-03 -5.490036e-03  9.187242e-04 -6.896580e-04
## SM.C16.0_T2        2.001695e-02 -1.509264e-02 -3.931704e-03  1.792236e-02
## SM.C16.1_T2        3.511162e-02 -2.720934e-02  6.797752e-03  1.468980e-03
## SM.C18.0_T2        7.730339e-02 -3.227226e-02  1.799971e-02  6.100133e-02
## SM.C18.1_T2        7.299691e-02 -4.046844e-02  2.280768e-02  1.914312e-02
## SM.C20.2_T2        4.827234e-03 -7.607502e-03  7.882929e-04 -3.049654e-04
## SM.C24.0_T2       -2.695671e-02 -1.398219e-02 -2.704923e-02 -8.847864e-03
## SM.C24.1_T2        1.970881e-02 -4.368514e-02 -4.657549e-02  4.106153e-02
## MEDDM_T4          -9.383916e-04 -1.229670e-02 -4.615668e-03  6.893428e-03
## MEDCOL_T4         -9.730286e-03 -2.979860e-03  7.672935e-03 -4.696380e-03
## MEDINF_T4          1.023270e-04  6.844283e-03  1.283825e-02 -1.439484e-02
## MEDHTA_T4          9.131447e-04  6.136403e-04  1.454952e-02  2.834590e-03
## GLU_T4            -4.230280e-02  3.472474e-03 -7.334732e-02 -8.510670e-02
## INS_T4             1.405955e-02  5.189941e-02 -2.137009e-02  5.043239e-02
## HOMA_T4            4.089748e-03  1.639104e-02 -1.597011e-02  5.567863e-03
## HBA1C_T4           1.009226e-02 -3.433935e-03 -7.202547e-03  6.970531e-03
## HBA1C.mmol.mol_T4  3.319927e-02  1.855462e-02 -4.060057e-03  3.359695e-02
## PESO_T4            9.668799e-04 -2.429384e-03 -3.941603e-02 -2.358927e-02
## bmi_T4             3.570487e-02  4.338217e-02  4.780044e-02  4.839325e-03
## CC_T4             -9.021067e-05  3.608555e-03  2.446192e-03 -1.298986e-03
## CINT_T4           -2.005571e-02 -7.282791e-03  1.666228e-02 -5.688193e-02
## CAD_T4             5.072528e-03 -6.976389e-02 -2.002414e-03 -3.464311e-02
## TAD_T4            -1.110884e-01  9.063517e-02  1.253132e-01 -9.307605e-02
## TAS_T4            -4.005693e-02  2.158012e-02  7.380090e-02 -9.937673e-02
## TG_T4             -6.054939e-02 -7.290611e-02  2.206064e-02 -3.568949e-02
## COL_T4            -1.878036e-02  3.202473e-02 -7.262518e-03  3.190474e-02
## LDL_T4            -2.910346e-02  5.395570e-02  2.796813e-03  4.737974e-02
## HDL_T4             3.593194e-02 -4.319409e-03 -6.075227e-02  6.199951e-02
## VLDL_T4           -2.925260e-02  3.499537e-02  4.499024e-02 -4.518061e-02
## PCR_T4            -6.115342e-02  5.938293e-02  9.857231e-02  1.634456e-01
## LEP_T4             5.781935e-02  1.234155e-01  3.550567e-02 -4.732903e-02
## ADIPO_T4           3.317430e-02 -5.764601e-02  8.820750e-03 -2.252433e-05
## GOT_T4            -1.468206e-01  3.994702e-02  6.191304e-02 -6.262857e-02
## GPT_T4            -1.483731e-01  2.891827e-02  4.959004e-02 -6.295915e-03
## GGT_T4            -1.634235e-01 -2.602860e-01  7.691349e-02  6.047146e-04
## URICO_T4          -2.855702e-02 -7.256085e-02 -1.207012e-03  1.406780e-02
## CREAT_T4           1.921042e-03 -1.006526e-02 -5.492213e-04 -4.638354e-03
## UREA_T4            1.196943e-01  1.144192e-01 -5.910676e-02 -1.411842e-02
## HIERRO_T4         -5.653604e-02 -1.350882e-01 -3.510620e-02  7.966195e-02
## TRANSF_T4         -7.658653e-02  4.094899e-02  1.895947e-02 -9.095033e-02
## FERR_T4            6.787866e-02  3.307919e-02  1.021986e-01  1.201265e-01
## Ile_T4            -3.834829e-02  4.286030e-02  5.967508e-02  2.445271e-02
## Leu_T4            -4.466059e-02  1.189065e-02  5.174837e-03  1.255840e-02
## Val_T4            -2.552049e-02  8.799074e-02  1.939998e-02  2.779421e-02
## Ala_T4            -4.377158e-02 -8.343212e-02  5.715076e-02  4.125949e-02
## Pro_T4             1.561728e-02  1.814744e-02 -1.298274e-02  2.919634e-02
## Gly_T4            -4.108831e-03 -3.786082e-02  3.665862e-02 -4.920889e-02
## Ser_T4            -5.747448e-02  1.074117e-01 -1.003808e-01  1.217544e-02
## Trp_T4             2.333362e-02  7.822499e-02  2.075418e-02  1.815257e-02
## Phe_T4            -4.153724e-03  4.564808e-02 -1.148696e-02  3.864889e-03
## Met_T4             7.686201e-03  7.384340e-03  3.566417e-02 -2.520378e-02
## Orn_T4             6.113002e-02  7.064832e-02  3.529851e-02 -3.556146e-02
## Arg_T4             7.691754e-02  1.025205e-02  6.633176e-02 -9.349149e-02
## His_T4             3.021023e-03 -4.476514e-02  2.998145e-02 -4.408814e-03
## Asn_T4             3.406581e-02 -6.931228e-02  5.043399e-02 -4.670981e-02
## Asp_T4             1.430667e-01  1.430784e-02 -7.715037e-02  1.100978e-02
## Glu_T4            -1.029465e-02 -3.798008e-02 -1.892969e-02 -4.940277e-05
## Gln_T4             1.303501e-02 -1.399487e-02  3.579324e-02  4.157040e-03
## Cit_T4             6.726162e-02  1.365730e-02 -2.376648e-03 -7.332045e-02
## Tyr_T4             3.501742e-02  6.445647e-02  6.777538e-02  3.260595e-02
## Thr_T4             5.396675e-02  1.084231e-02  6.380869e-02  1.436867e-03
## Lys_T4             3.920677e-02 -1.871605e-01  3.490895e-02 -6.313313e-02
## Creatinine_T4     -2.731410e-02 -3.632326e-02 -4.900159e-02  4.718515e-03
## Kynurenine_T4      2.610628e-02  1.073806e-02  8.529830e-02  8.493823e-02
## Putrescine_T4      1.267464e-01 -8.864619e-02  7.450930e-02  2.510479e-02
## Sarcosine_T4       2.947029e-03 -9.783575e-02  3.337760e-02 -9.399243e-02
## Serotonin_T4      -6.137454e-02  2.059712e-02 -4.389755e-02 -5.808980e-02
## Taurine_T4         1.115882e-01  4.436735e-02  2.684279e-02 -4.797747e-02
## SDMA_T4           -6.891292e-03 -9.818778e-03 -7.405098e-03 -6.699304e-03
## C0_T4             -1.184176e-02  6.709609e-02  2.603889e-02  7.600303e-02
## C2_T4             -4.842411e-02 -1.693020e-02 -1.592893e-02  2.899780e-02
## C3.OH_T4          -8.313507e-04 -3.705491e-03  6.617247e-03  5.317939e-04
## C6..C4.1.DC._T4    1.167860e-01 -3.380465e-02 -1.436952e-03 -4.274539e-02
## C5.DC..C6.OH._T4  -1.101545e-01 -2.912210e-02  1.514781e-01  4.006277e-02
## C7.DC_T4          -4.960860e-02 -3.710415e-02  8.280519e-02  8.373481e-02
## C8_T4             -7.666826e-03 -6.149456e-03  1.026761e-02 -7.813555e-05
## C10_T4            -1.391524e-02 -5.248685e-03  5.736083e-03  1.187533e-03
## C10.1_T4          -3.295575e-03 -5.040559e-03  6.311470e-03 -1.020862e-03
## C10.2_T4          -9.807131e-04 -5.217392e-03  5.061078e-03 -1.576417e-03
## C14.1_T4          -3.752931e-03 -5.811230e-03  6.870611e-03 -2.850205e-03
## C14.2_T4          -1.815230e-03 -6.652163e-03  5.270226e-03 -3.017464e-03
## C16.1_T4          -5.131663e-02 -1.880187e-02  9.457067e-02 -4.850139e-03
## C16.2_T4          -1.780196e-04 -4.830604e-03  4.930808e-03 -3.184577e-03
## C16.2.OH_T4       -5.056500e-02 -1.819532e-02  9.342047e-02 -4.950025e-03
## C18.1_T4          -2.173086e-03 -3.757112e-03  6.819669e-03 -5.149098e-03
## C18.1.OH_T4       -5.257854e-05 -4.634744e-03  4.448255e-03 -2.089146e-03
## C18.2_T4          -1.104606e-03 -4.991422e-03  5.617392e-03 -3.274856e-03
## lysoPC.a.C16.0_T4  5.016742e-02  1.580929e-02 -7.885658e-03 -7.172864e-02
## lysoPC.a.C16.1_T4  2.523188e-02 -3.149313e-02  2.464833e-02 -4.994494e-03
## lysoPC.a.C17.0_T4  3.319815e-02 -1.158616e-02 -3.288674e-02 -9.893439e-03
## lysoPC.a.C18.0_T4  4.864338e-02 -2.488886e-03 -4.380413e-02 -3.292454e-02
## lysoPC.a.C18.1_T4 -1.045681e-02 -5.209896e-02 -1.886991e-02 -4.731208e-02
## lysoPC.a.C18.2_T4  1.259878e-02 -9.104039e-03  5.455885e-02  8.582325e-03
## lysoPC.a.C20.3_T4  1.723562e-02 -3.133095e-02 -3.172765e-02  3.107050e-02
## lysoPC.a.C20.4_T4  2.060969e-02 -5.294693e-02 -1.141682e-02 -2.760723e-03
## lysoPC.a.C24.0_T4 -6.077428e-04 -7.584823e-03  3.889839e-03 -1.648267e-03
## lysoPC.a.C26.0_T4  4.782129e-02 -3.451355e-02 -7.515611e-04  3.828022e-02
## lysoPC.a.C26.1_T4  4.096243e-03  2.030318e-03  4.914165e-03 -9.789826e-03
## lysoPC.a.C28.0_T4  4.550749e-02  1.009990e-02  1.337834e-02  2.124657e-02
## lysoPC.a.C28.1_T4  5.645634e-03 -6.297471e-03  6.457816e-04 -1.524638e-03
## PC.aa.C24.0_T4     4.134529e-02  1.108169e-02  1.857120e-02 -1.183766e-01
## PC.aa.C28.1_T4     1.074155e-02  6.523430e-03 -3.928094e-03 -5.661503e-03
## PC.aa.C30.0_T4    -9.841760e-04 -9.880482e-03  1.051343e-02 -7.590681e-03
## PC.aa.C32.0_T4    -1.948407e-02  4.322656e-02 -1.154436e-02 -1.594762e-02
## PC.aa.C32.1_T4    -3.910904e-02 -8.690181e-02  4.681784e-02  3.716744e-02
## PC.aa.C32.3_T4    -7.848910e-04 -3.131392e-03  3.957162e-03 -1.282470e-03
## PC.aa.C34.1_T4    -4.630573e-02 -4.377719e-02  4.132795e-03 -1.926156e-03
## PC.aa.C34.2_T4     1.271898e-02  6.161323e-02  3.926346e-02 -1.655748e-02
## PC.aa.C34.3_T4     2.342860e-02 -1.438350e-03  5.343386e-02  4.292894e-02
## PC.aa.C34.4_T4     1.796357e-03 -4.361839e-03  2.650266e-03  2.184048e-03
## PC.aa.C36.0_T4     4.944963e-03  7.222419e-03 -1.158880e-02  1.315270e-02
## PC.aa.C36.1_T4    -7.435036e-02 -8.079194e-03  1.219066e-02  2.811268e-02
## PC.aa.C36.2_T4    -1.374854e-02  2.629006e-02  3.994852e-02  1.169537e-02
## PC.aa.C36.3_T4    -1.369219e-02  6.151696e-02 -3.290178e-02  5.603427e-02
## PC.aa.C36.4_T4    -1.890483e-02  2.946243e-02 -4.912054e-02  2.128071e-02
## PC.aa.C36.5_T4    -2.067302e-02  3.159903e-02 -8.090908e-02  8.375879e-03
## PC.aa.C38.0_T4    -1.827890e-02  3.160664e-02 -6.314143e-02  1.348623e-03
## PC.aa.C38.1_T4     3.278742e-03  3.073375e-02 -1.472787e-03  1.752902e-02
## PC.aa.C38.3_T4    -2.082771e-02 -2.319765e-02 -6.063594e-02  1.004762e-01
## PC.aa.C38.4_T4    -2.566292e-02  1.669630e-02 -6.353493e-02  2.511039e-02
## PC.aa.C38.5_T4    -2.913118e-03  1.577628e-02 -4.153936e-02 -2.665275e-02
## PC.aa.C38.6_T4    -3.214383e-02  1.284821e-02 -6.755953e-02 -1.582630e-03
## PC.aa.C40.1_T4     3.159923e-02  3.483436e-02 -7.944876e-02  8.770724e-02
## PC.aa.C40.2_T4     3.094742e-03 -3.851109e-03  5.346761e-04  4.458413e-03
## PC.aa.C40.3_T4     4.152626e-04 -5.747972e-03  4.330306e-04  5.429887e-03
## PC.aa.C40.4_T4     5.268347e-03 -8.469543e-03 -7.776729e-04 -2.534184e-04
## PC.aa.C40.5_T4     1.117381e-02 -2.989983e-03 -1.029204e-02 -6.598034e-03
## PC.aa.C40.6_T4    -2.604168e-02 -1.526610e-02 -7.747054e-02  3.477007e-02
## PC.aa.C42.0_T4     1.505914e-03  1.870588e-03 -6.787534e-03  1.995589e-03
## PC.aa.C42.1_T4     1.678036e-03 -2.067487e-03 -1.868049e-03 -4.016141e-04
## PC.aa.C42.2_T4     3.316763e-03 -3.470791e-03  1.880659e-03 -5.218368e-04
## PC.aa.C42.4_T4     2.978436e-03 -3.165559e-03  3.039246e-03  2.695011e-03
## PC.aa.C42.5_T4    -1.164182e-03 -3.275753e-03  3.871577e-03  1.024475e-03
## PC.aa.C42.6_T4     7.062070e-02 -1.301367e-02 -8.065531e-03 -3.810083e-02
## PC.ae.C30.0_T4     5.352201e-02 -3.281107e-02  5.236682e-02 -7.314665e-02
## PC.ae.C32.1_T4     1.260622e-02  7.969304e-03 -6.057103e-03  6.242640e-03
## PC.ae.C32.2_T4     5.360389e-04  1.115152e-04 -4.307824e-03 -2.824457e-03
## PC.ae.C34.0_T4     9.710077e-04 -5.656528e-03 -2.264797e-05 -6.722738e-04
## PC.ae.C34.1_T4    -3.843771e-04  3.469396e-02 -2.637429e-02  1.164089e-02
## PC.ae.C34.2_T4     2.858501e-02  2.584249e-02 -3.786854e-02  9.300457e-03
## PC.ae.C34.3_T4     3.782428e-02 -6.510348e-03 -2.147326e-02  4.133914e-03
## PC.ae.C36.0_T4    -5.331637e-03 -4.913188e-03 -5.961108e-03 -1.571630e-03
## PC.ae.C36.1_T4     2.819993e-02  1.566506e-02 -6.520191e-03  1.530766e-02
## PC.ae.C36.2_T4     3.806288e-02  1.633106e-02 -4.080112e-02  2.215273e-02
## PC.ae.C36.3_T4     1.726688e-03  1.418633e-02 -2.535516e-02  8.931628e-03
## PC.ae.C36.4_T4    -2.639770e-02  6.245655e-02 -3.638806e-02 -5.131865e-05
## PC.ae.C36.5_T4     8.152819e-03  4.775768e-02 -3.352536e-02 -1.572088e-02
## PC.ae.C38.0_T4    -3.381487e-03 -8.663793e-04 -2.097661e-03  7.651297e-03
## PC.ae.C38.2_T4     1.944896e-02  1.637801e-02  4.954651e-03  2.025038e-02
## PC.ae.C38.3_T4     1.081833e-02  7.500801e-03 -9.847179e-03  2.656284e-02
## PC.ae.C38.4_T4     1.338769e-03  4.686998e-02 -4.508668e-02  2.691895e-02
## PC.ae.C38.5_T4    -4.117669e-02  6.548312e-02 -3.499954e-02 -1.908475e-02
## PC.ae.C38.6_T4    -2.606845e-03  3.842872e-02 -3.756273e-02 -1.369255e-02
## PC.ae.C40.1_T4     7.435166e-03  3.798424e-03 -3.529576e-03  9.769995e-03
## PC.ae.C40.2_T4     1.619013e-03 -4.863446e-04 -1.183336e-02  4.985598e-03
## PC.ae.C40.3_T4     1.195453e-02  3.359884e-03 -1.029846e-03  1.832841e-02
## PC.ae.C40.4_T4     4.789127e-03  2.538489e-02  4.594510e-04  1.281591e-02
## PC.ae.C40.5_T4     3.031950e-03  3.193503e-02  3.610340e-04 -5.488736e-03
## PC.ae.C40.6_T4     5.489628e-03  1.709564e-02 -3.066611e-02 -1.733838e-03
## PC.ae.C42.1_T4     7.722434e-04 -6.559735e-03 -8.455351e-04  6.109259e-03
## PC.ae.C42.2_T4     4.914977e-04 -4.310613e-03  4.620055e-03  5.840536e-03
## PC.ae.C42.3_T4     7.730872e-03  4.777045e-03  4.223729e-03 -6.673728e-04
## PC.ae.C42.4_T4     9.210269e-05  5.132488e-03  4.142622e-03  5.237672e-03
## PC.ae.C42.5_T4     1.574754e-03  4.078942e-02  4.954544e-03 -2.098645e-02
## PC.ae.C44.3_T4     4.346605e-03 -4.699102e-03  2.899677e-03  5.440816e-04
## PC.ae.C44.4_T4     2.835871e-03 -3.828077e-03  4.062367e-03 -1.842915e-04
## PC.ae.C44.5_T4     2.358655e-03  1.601070e-02  2.015203e-02 -1.397428e-02
## PC.ae.C44.6_T4     7.711288e-03  1.035433e-02  3.169855e-03 -9.695337e-03
## SM..OH..C14.1_T4   3.955861e-02 -1.011091e-03 -1.695403e-02 -2.690587e-02
## SM..OH..C16.1_T4   8.735004e-03 -7.798223e-03 -1.059034e-02 -3.704249e-03
## SM..OH..C22.1_T4   1.023259e-02  1.367903e-02  2.772078e-02 -4.692367e-02
## SM..OH..C22.2_T4   1.796205e-02  2.664050e-03 -3.944362e-03 -4.876521e-02
## SM..OH..C24.1_T4  -2.086088e-03 -3.029050e-03  8.825109e-03 -9.989451e-03
## SM.C16.0_T4       -2.578615e-02  3.118929e-02  1.277430e-02 -6.126104e-02
## SM.C16.1_T4       -2.745173e-02  1.345921e-02 -3.986571e-03 -6.939342e-02
## SM.C18.0_T4       -7.575350e-03  1.919290e-03  4.852531e-02  2.003990e-03
## SM.C18.1_T4       -2.709565e-02 -2.462113e-02  3.613676e-02 -1.459797e-02
## SM.C20.2_T4        1.533681e-03 -4.924136e-03  5.628410e-03 -2.821648e-03
## SM.C24.0_T4       -3.749614e-02 -6.395831e-02  3.641547e-02 -4.116920e-02
## SM.C24.1_T4       -2.041251e-02  3.666487e-03  1.383720e-02 -6.288198e-02
## MEDDM_T5          -2.063251e-02  3.396545e-03 -2.399198e-03 -1.907715e-02
## MEDCOL_T5         -2.063251e-02  3.396545e-03 -2.399198e-03 -1.907715e-02
## MEDINF_T5         -2.259225e-02  1.481485e-02  7.415911e-03 -3.406658e-02
## MEDHTA_T5         -2.226526e-02 -4.316351e-03 -1.046747e-02 -1.036532e-02
## GLU_T5            -7.661183e-02  4.933121e-02 -6.004942e-02  3.761993e-02
## INS_T5            -4.286528e-02  1.031298e-01  1.044872e-02  7.359608e-02
## HOMA_T5           -1.538664e-02  4.253881e-02 -2.135297e-04  3.253889e-02
## HBA1C_T5           1.068110e-04  4.615063e-03 -2.098526e-02 -3.974273e-03
## HBA1C.mmol.mol_T5 -7.390671e-04  4.657042e-02 -5.135424e-02 -3.462753e-03
## PESO_T5            1.876216e-02  1.435659e-02 -5.357401e-02 -1.995277e-02
## bmi_T5             3.195703e-02  7.905974e-02  3.524438e-02  2.077902e-03
## CC_T5             -1.200656e-04 -4.713545e-03  1.602601e-03 -3.877849e-03
## CINT_T5           -7.842030e-04 -1.595128e-02 -4.584657e-04 -3.275649e-02
## CAD_T5             2.910551e-02 -2.555421e-02 -3.330191e-02  1.604723e-02
## TAD_T5            -1.569007e-02 -1.152572e-02  6.892586e-04 -2.465859e-02
## TAS_T5             4.896416e-02 -9.061131e-02 -4.668352e-02  3.338855e-02
## TG_T5             -2.835336e-02  5.734319e-02  1.016820e-01 -3.951411e-02
## COL_T5             1.396038e-02  2.372425e-02  5.896690e-02 -4.319608e-03
## LDL_T5             1.072550e-02  4.205204e-02  9.367430e-02 -1.085651e-03
## HDL_T5             5.382546e-02 -5.256011e-02 -8.863590e-02  4.859408e-02
## VLDL_T5           -1.285238e-03  5.615610e-02  6.952201e-02 -1.986953e-02
## PCR_T5            -1.940740e-03  7.789043e-02  3.165946e-02  5.105746e-02
## LEP_T5             4.019997e-02  2.832348e-02  6.343014e-02 -4.530587e-02
## ADIPO_T5           1.930971e-02 -4.702523e-02 -4.970920e-02  2.244974e-02
## GOT_T5            -1.016708e-01  6.063685e-02  1.366361e-02 -5.097217e-02
## GPT_T5            -6.529613e-02  1.531429e-01 -5.949180e-02 -2.734485e-02
## GGT_T5            -1.090856e-02  7.764638e-03 -5.273746e-03 -1.921061e-03
## URICO_T5          -7.979250e-03 -1.367467e-02 -1.400036e-02 -1.881807e-02
## CREAT_T5           1.182822e-03 -6.269518e-03 -7.686990e-03 -3.638811e-03
## UREA_T5            1.636254e-02  9.134357e-02 -3.737888e-02 -4.617264e-02
## HIERRO_T5         -5.948542e-02  8.226784e-02  1.042985e-01 -5.850895e-02
## TRANSF_T5         -4.448111e-02 -4.866008e-02  5.912047e-02 -1.178298e-01
## FERR_T5            1.375792e-01  4.168441e-02  3.058181e-02  7.400060e-02
## Ile_T5            -2.335521e-02  2.839629e-02 -6.359413e-02 -9.207185e-03
## Leu_T5            -9.262132e-03  4.261992e-02 -4.286999e-02 -9.051500e-03
## Val_T5            -1.846523e-02  7.233302e-02  1.472181e-02  1.845684e-02
## Ala_T5            -1.218757e-02  1.887469e-02 -2.686723e-02  4.309524e-02
## Pro_T5             4.368967e-02  6.670884e-03 -3.318052e-02  1.146798e-02
## Gly_T5            -5.075802e-02  5.202009e-03 -3.191000e-02  1.356819e-02
## Ser_T5            -6.126752e-02 -6.603536e-03  3.274839e-02  3.959551e-02
## Trp_T5            -4.088646e-02  4.200130e-02 -1.838998e-03 -7.550473e-02
## Phe_T5             6.025645e-03  3.737137e-02 -1.040535e-02 -3.756055e-03
## Met_T5            -1.010016e-02 -4.155338e-02 -1.091402e-01 -5.682001e-02
## Orn_T5             6.846315e-02 -9.632045e-03  3.524526e-02  5.963437e-02
## Arg_T5            -1.685596e-02 -2.745376e-02  6.223140e-03 -3.302044e-02
## His_T5            -3.166296e-03  2.949072e-03 -2.212594e-02  3.119572e-02
## Asn_T5            -4.238956e-02 -3.878704e-03 -2.396376e-02  2.703009e-02
## Asp_T5            -2.046504e-02 -8.070707e-03  2.836920e-02  9.547651e-02
## Glu_T5             1.766212e-02  1.674443e-02  1.817142e-03  4.998342e-02
## Gln_T5             1.455899e-02  1.650833e-02 -3.541299e-02  1.769918e-02
## Cit_T5            -5.940502e-03  4.062371e-02  4.448761e-02 -4.014506e-03
## Tyr_T5             2.175484e-02  1.939684e-02 -3.407922e-02 -3.175147e-02
## Thr_T5             4.643260e-03 -5.158544e-02  6.776607e-02  4.366882e-04
## Lys_T5             1.344589e-02  2.119614e-02  1.850358e-02 -5.820072e-02
## Creatinine_T5     -3.891051e-02  3.192972e-02 -1.233823e-01 -8.780096e-02
## Kynurenine_T5     -6.790225e-02 -2.273415e-02 -1.169923e-02  5.399553e-02
## Putrescine_T5     -4.551039e-02  5.344340e-02  1.041270e-01 -7.064234e-02
## Sarcosine_T5       4.462548e-02 -1.060610e-02 -1.020983e-01 -3.308961e-02
## Serotonin_T5      -2.407684e-02  1.233327e-03 -4.454810e-02 -4.299751e-02
## Taurine_T5         4.275405e-02 -3.400156e-03 -7.477988e-02  8.211890e-02
## SDMA_T5           -7.191241e-03 -9.145204e-03 -6.583529e-03 -5.363682e-03
## C0_T5             -1.159347e-02  5.105701e-02 -2.183733e-02 -9.502992e-03
## C2_T5             -1.258282e-01  4.435295e-02 -4.937393e-02 -3.015263e-02
## C3.OH_T5           1.634429e-03 -3.684104e-03  5.082671e-03 -2.099118e-04
## C6..C4.1.DC._T5    6.500731e-02  8.132438e-02  1.563093e-01 -2.820093e-03
## C5.DC..C6.OH._T5  -1.172526e-02 -1.344788e-03 -1.938603e-02 -2.199761e-02
## C7.DC_T5          -5.039519e-02 -2.142538e-02  2.385362e-02  1.837777e-02
## C8_T5              3.132315e-03 -5.029991e-03  5.172846e-03  4.177123e-03
## C10_T5             1.656454e-03 -9.316374e-03  1.696124e-03  6.397771e-03
## C10.1_T5          -1.191559e-02 -8.165869e-02 -5.870505e-03 -1.891337e-02
## C10.2_T5           1.456168e-03 -5.573318e-03  3.746525e-03 -1.976838e-04
## C14.1_T5          -5.271323e-04 -5.020701e-03  2.890582e-03 -1.719320e-03
## C14.2_T5           6.445596e-04 -4.696579e-03  3.384486e-03  3.984659e-04
## C16.1_T5           5.362316e-04 -4.869440e-03  2.686849e-03 -1.596213e-03
## C16.2_T5           7.029253e-04 -4.988720e-03  3.144477e-03 -1.446168e-03
## C16.2.OH_T5       -8.024819e-03  8.086120e-03  1.355295e-02  4.486308e-02
## C18.1_T5          -3.308839e-04 -4.719361e-03  2.350611e-03 -1.412397e-03
## C18.1.OH_T5        5.119609e-04 -4.819003e-03  2.742021e-03 -1.080217e-03
## C18.2_T5           7.865301e-04 -4.873051e-03  3.557322e-03 -1.485867e-03
## lysoPC.a.C16.0_T5  1.160088e-02  2.176183e-02  1.416990e-02  2.761551e-02
## lysoPC.a.C16.1_T5  4.451875e-02  3.462015e-02 -1.487590e-02 -1.586742e-03
## lysoPC.a.C17.0_T5  2.782078e-03 -1.326639e-02 -1.094991e-02  4.346435e-03
## lysoPC.a.C18.0_T5  1.513190e-03  5.824165e-03  9.514178e-03  3.204567e-03
## lysoPC.a.C18.1_T5 -5.132473e-02  1.259240e-02 -4.092793e-02  1.054859e-02
## lysoPC.a.C18.2_T5 -2.664285e-02  2.070686e-03 -2.585070e-02  6.645601e-02
## lysoPC.a.C20.3_T5  3.824849e-02  4.786458e-03 -1.649133e-02  7.274634e-02
## lysoPC.a.C20.4_T5 -3.595378e-03  1.117060e-02  7.037118e-03  9.208036e-02
## lysoPC.a.C24.0_T5  3.938657e-03 -6.294465e-03  7.307146e-03 -3.814087e-03
## lysoPC.a.C26.0_T5  3.594179e-03  3.299938e-04  8.496731e-03 -2.002815e-03
## lysoPC.a.C26.1_T5  9.351273e-04 -3.927562e-03  5.072345e-03 -7.146002e-04
## lysoPC.a.C28.0_T5  5.921783e-04 -7.830675e-03  4.774435e-02 -1.264752e-01
## lysoPC.a.C28.1_T5  4.217834e-03 -5.825626e-03  4.211584e-03 -3.192744e-04
## PC.aa.C24.0_T5     8.044480e-02 -7.304873e-02 -7.086872e-03 -8.972769e-02
## PC.aa.C28.1_T5     4.825156e-03  2.909717e-03  6.858507e-03  2.856782e-03
## PC.aa.C30.0_T5     6.198450e-03  1.074677e-02  9.016730e-04  6.518261e-03
## PC.aa.C32.0_T5     2.319007e-02  3.914376e-02 -3.010074e-02  1.190019e-02
## PC.aa.C32.1_T5     9.325103e-02  4.770373e-02 -2.072622e-02 -4.017156e-03
## PC.aa.C32.3_T5     1.844037e-03 -5.145061e-03  1.936312e-03 -3.940912e-04
## PC.aa.C34.1_T5     1.213417e-02  1.740112e-02 -2.911015e-02  2.895786e-02
## PC.aa.C34.2_T5     3.812046e-02 -9.466442e-03  2.130815e-02  2.428663e-02
## PC.aa.C34.3_T5     9.697656e-02  1.630324e-02 -1.098011e-02  5.651430e-03
## PC.aa.C34.4_T5     7.181871e-03 -4.397249e-03 -2.377730e-03  4.434318e-03
## PC.aa.C36.0_T5     3.277461e-03  2.475818e-03 -2.541152e-03 -1.422899e-02
## PC.aa.C36.1_T5     1.610321e-02 -2.762112e-02 -5.657103e-02 -5.027229e-03
## PC.aa.C36.2_T5     2.628302e-02 -1.823707e-02 -3.907663e-03 -2.874910e-02
## PC.aa.C36.3_T5     7.216462e-02  1.278404e-02 -5.004173e-02  4.674763e-02
## PC.aa.C36.4_T5     4.300588e-02 -1.752188e-02 -4.579285e-03  6.044402e-02
## PC.aa.C36.5_T5    -1.680914e-02 -1.703603e-02 -1.088333e-01 -4.573507e-02
## PC.aa.C38.0_T5    -3.421383e-02  1.364583e-02 -4.958969e-02 -4.048201e-02
## PC.aa.C38.1_T5     7.032599e-03  6.158823e-03 -3.211169e-03 -1.217964e-02
## PC.aa.C38.3_T5     8.401673e-02  1.544881e-02 -3.539716e-02  4.331257e-02
## PC.aa.C38.4_T5     3.721230e-02 -6.268238e-03  1.069868e-03  3.186767e-02
## PC.aa.C38.5_T5     1.800039e-02  2.457727e-02 -6.642515e-03 -6.969446e-03
## PC.aa.C38.6_T5    -1.273720e-02  1.249064e-02 -5.998865e-02 -3.369463e-02
## PC.aa.C40.1_T5     2.276167e-02 -3.019358e-02  7.158363e-02 -1.353406e-01
## PC.aa.C40.2_T5     7.665041e-03 -2.446329e-04  8.486395e-03 -3.512689e-03
## PC.aa.C40.3_T5     8.252138e-03  2.507984e-03  8.269519e-03 -4.721433e-03
## PC.aa.C40.4_T5     1.317235e-02  1.522707e-02  2.515293e-02 -6.880343e-03
## PC.aa.C40.5_T5     3.892879e-03  2.789110e-02  3.151201e-03 -1.435688e-02
## PC.aa.C40.6_T5    -5.780979e-03  1.351213e-02 -7.592793e-02 -4.681194e-02
## PC.aa.C42.0_T5    -7.478434e-04 -1.450289e-03 -5.688836e-03 -5.589623e-03
## PC.aa.C42.1_T5     1.291793e-03 -1.684390e-03 -8.768155e-04 -3.817198e-03
## PC.aa.C42.2_T5     3.599035e-03 -2.922146e-03  4.831054e-03 -5.608948e-03
## PC.aa.C42.4_T5     4.495157e-03 -1.548334e-03  7.636920e-03 -1.861050e-03
## PC.aa.C42.5_T5     3.494712e-03 -2.408399e-03  1.351638e-03 -6.779735e-04
## PC.aa.C42.6_T5    -7.282870e-02  1.195390e-02  1.238757e-02 -8.004739e-03
## PC.ae.C30.0_T5    -2.880665e-02 -4.372447e-03  1.642803e-02  3.442328e-02
## PC.ae.C32.1_T5    -6.510425e-03  1.398804e-02  1.111944e-02  7.510269e-03
## PC.ae.C32.2_T5    -6.163385e-04 -1.773943e-03 -1.769977e-04 -4.706319e-03
## PC.ae.C34.0_T5     3.869252e-03 -3.471890e-03 -5.329338e-04  3.121347e-03
## PC.ae.C34.1_T5     3.164128e-03 -4.444090e-04 -3.189058e-02  1.112537e-02
## PC.ae.C34.2_T5    -2.524268e-02  5.158723e-03 -3.357219e-02 -1.510845e-02
## PC.ae.C34.3_T5    -2.239865e-02 -4.712179e-02 -2.724658e-02  2.121625e-03
## PC.ae.C36.0_T5    -7.772987e-03  4.144639e-03  3.860922e-03 -1.252618e-02
## PC.ae.C36.1_T5     3.003064e-02  4.621453e-03 -2.887071e-04  4.996455e-03
## PC.ae.C36.2_T5     4.008748e-02 -3.210691e-02 -2.855706e-02  5.260212e-04
## PC.ae.C36.3_T5    -9.709423e-03 -3.701000e-03 -2.624241e-02 -1.332089e-03
## PC.ae.C36.4_T5    -4.900403e-02  6.544854e-02 -2.341743e-02  2.575548e-04
## PC.ae.C36.5_T5    -2.528522e-02  2.316657e-02 -3.515697e-02  5.353526e-02
## PC.ae.C38.0_T5     4.332567e-03 -1.039907e-05 -1.129732e-02 -7.013691e-03
## PC.ae.C38.2_T5     2.942671e-02  1.430953e-03  2.052230e-02 -4.962246e-03
## PC.ae.C38.3_T5     1.962232e-02 -8.564865e-03 -5.485240e-03  1.830710e-02
## PC.ae.C38.4_T5     1.900477e-02 -1.085416e-02  8.696199e-03  3.301920e-02
## PC.ae.C38.5_T5    -6.828767e-02  3.968783e-02 -3.469725e-02 -2.312278e-02
## PC.ae.C38.6_T5    -2.411862e-02  1.424122e-02 -3.278106e-02 -1.274579e-02
## PC.ae.C40.1_T5     7.046339e-03 -2.186589e-03  1.697068e-03 -7.028483e-03
## PC.ae.C40.2_T5     4.095610e-03 -3.079531e-03 -9.385036e-03 -2.288928e-03
## PC.ae.C40.3_T5     1.069446e-02 -2.352761e-03  2.632826e-03  1.313637e-02
## PC.ae.C40.4_T5     5.292970e-03  1.077952e-02  1.488682e-02  8.411714e-03
## PC.ae.C40.5_T5    -8.041828e-03 -1.237549e-03 -2.460355e-04 -2.689182e-03
## PC.ae.C40.6_T5    -1.975660e-02 -4.955494e-03 -3.067441e-02 -1.629586e-02
## PC.ae.C42.1_T5     6.008552e-03 -1.088671e-03  6.570596e-03 -1.725064e-03
## PC.ae.C42.2_T5     4.510001e-03 -1.981541e-03 -2.385275e-03 -2.327841e-03
## PC.ae.C42.3_T5     5.054569e-03 -1.130538e-03  3.508568e-03 -2.563966e-03
## PC.ae.C42.4_T5     5.806277e-03  1.573357e-03  7.260929e-03  4.203770e-03
## PC.ae.C42.5_T5    -1.194159e-02  3.850140e-03 -7.061384e-03 -3.575827e-03
## PC.ae.C44.3_T5     4.181571e-03 -1.954463e-03  5.327805e-03 -1.283833e-03
## PC.ae.C44.4_T5     2.477891e-03 -3.787542e-03 -1.133262e-03 -1.549697e-03
## PC.ae.C44.5_T5    -7.693542e-03 -7.967067e-03 -1.254030e-02 -8.805506e-03
## PC.ae.C44.6_T5     2.767841e-03 -6.806991e-03 -4.169909e-03 -2.431146e-03
## SM..OH..C14.1_T5   7.409197e-03 -2.167392e-02 -1.593811e-02  1.564585e-03
## SM..OH..C16.1_T5   4.775700e-03 -1.234330e-02 -1.653738e-02  7.279738e-03
## SM..OH..C22.1_T5   2.044719e-03 -1.223480e-02  4.998330e-02 -1.828390e-02
## SM..OH..C22.2_T5  -3.466251e-03 -2.757880e-02  9.079549e-03 -1.411447e-02
## SM..OH..C24.1_T5  -3.110955e-04 -3.752284e-03  5.125309e-03  1.154184e-03
## SM.C16.0_T5       -1.099966e-02  3.729468e-02 -1.625917e-02  3.231771e-02
## SM.C16.1_T5       -4.901089e-02 -7.370282e-03  1.928279e-02 -2.890613e-02
## SM.C18.0_T5        5.290456e-02  2.562524e-02 -1.136471e-02  4.160703e-02
## SM.C18.1_T5       -1.367238e-02 -1.103786e-02  4.313382e-03  5.655698e-03
## SM.C20.2_T5        3.329037e-03 -3.948888e-03  2.329421e-03  1.914815e-03
## SM.C24.0_T5        1.201470e-02 -1.136474e-02  2.153050e-02  2.072764e-02
## SM.C24.1_T5       -1.060684e-03  1.788389e-02 -4.742625e-02  4.260675e-02
##                            PC29          PC30          PC31          PC32
## GLU_T0            -1.790906e-02  7.906290e-03  2.109214e-02  0.0699200309
## INS_T0            -4.452453e-02  5.343923e-02 -1.162893e-02  0.0327575490
## HOMA_T0           -3.711695e-02  4.152912e-02 -6.838792e-03  0.0402124108
## HBA1C_T0          -3.686088e-05  2.207351e-02  2.596719e-02 -0.0254609230
## HBA1C.mmol.mol_T0  1.121399e-02  4.115266e-02  6.145962e-02 -0.0749300698
## PESO_T0            7.025288e-02 -2.980327e-02 -1.907826e-03 -0.0491126100
## bmi_T0             7.101574e-02 -1.592726e-02  3.560747e-02 -0.0190772940
## CC_T0              7.825635e-03  5.455575e-03  7.759674e-03  0.0113747148
## CINT_T0            1.035211e-01 -2.861599e-02  3.125923e-02 -0.0366086110
## CAD_T0             4.542051e-02 -9.497781e-03  3.444639e-02 -0.1142895370
## TAD_T0             1.097964e-02  7.495197e-02  4.481029e-02 -0.0194661854
## TAS_T0            -3.385137e-02  5.090153e-02  1.020968e-02 -0.0163415276
## TG_T0              7.695801e-02  1.079485e-01 -8.787045e-02  0.0412776010
## COL_T0             1.727134e-02 -1.245109e-02  8.711958e-02 -0.0294328560
## LDL_T0             4.330979e-02 -6.025097e-03  1.109099e-01  0.0038175411
## HDL_T0            -3.489376e-02 -7.339026e-02 -2.764138e-03 -0.0507637083
## VLDL_T0            7.738630e-02  1.093717e-01 -8.795318e-02  0.0427887462
## PCR_T0             2.465495e-02 -5.434997e-03  2.345402e-02  0.0352239532
## LEP_T0             3.401750e-02  3.923885e-03  3.643302e-02 -0.0089590480
## ADIPO_T0          -4.700989e-02  1.034369e-02 -7.607591e-02  0.0022763320
## GOT_T0             7.455592e-02  5.429032e-02 -1.849528e-02 -0.0401898259
## GPT_T0             1.288475e-02  2.340881e-02 -3.063516e-02 -0.0233647889
## GGT_T0             1.144469e-01 -1.855699e-02 -1.159828e-02  0.0226001393
## URICO_T0           1.246616e-02 -2.532154e-02 -1.902146e-02  0.0087589019
## CREAT_T0          -3.276429e-04 -7.198971e-03  3.068938e-03 -0.0014782731
## UREA_T0           -3.220845e-02 -1.277350e-01  3.090722e-02 -0.0629677153
## HIERRO_T0         -3.164237e-02 -9.376169e-03 -3.051336e-03 -0.0119760330
## TRANSF_T0         -6.526605e-02 -5.239492e-02  2.995152e-02  0.0666832747
## FERR_T0            9.022415e-03  1.986946e-02 -7.827128e-02  0.0074574583
## Ile_T0            -1.221253e-01  8.621804e-03  5.709224e-02 -0.0310941971
## Leu_T0            -1.296989e-01 -2.161588e-02  7.516511e-02 -0.0254102006
## Val_T0            -5.597950e-02 -6.390066e-02  4.686816e-02 -0.0107106418
## Ala_T0             3.990499e-02  5.436716e-02 -6.768553e-02  0.0346154773
## Pro_T0            -6.895418e-02 -7.286989e-04 -7.074011e-03  0.0601249213
## Gly_T0            -8.277426e-02 -2.357164e-03 -9.258060e-02 -0.0349085739
## Ser_T0            -7.695129e-02 -3.316737e-02 -3.400400e-02 -0.0256928003
## Trp_T0            -6.188935e-03 -7.256690e-03 -1.885192e-02 -0.0659532583
## Phe_T0            -2.958239e-02  1.146229e-02 -1.391154e-02 -0.0340204535
## Met_T0            -9.488313e-04  2.322654e-02 -2.537521e-02  0.0029768618
## Orn_T0             5.274738e-02  1.100935e-03  2.232221e-02  0.0471204569
## Arg_T0             4.891934e-03 -7.876705e-02  3.817732e-02  0.0600741318
## His_T0            -3.789476e-02 -4.348713e-02  3.565227e-02 -0.0179398493
## Asn_T0            -3.564949e-02  3.829716e-02  1.449611e-01 -0.0437593414
## Asp_T0             4.404533e-02 -7.443458e-02  1.390183e-03  0.0288527103
## Glu_T0             4.648941e-02 -2.539456e-02  1.770417e-02  0.0348224299
## Gln_T0            -3.654019e-02  2.094983e-02 -9.085165e-03  0.0535298305
## Cit_T0             8.699491e-02  3.007418e-02 -9.524344e-03  0.0389879036
## Tyr_T0            -1.908489e-02 -1.713954e-02 -5.403030e-02 -0.1057489714
## Thr_T0            -4.216801e-02 -1.112345e-01  1.868544e-02  0.0802896736
## Lys_T0            -4.829986e-02 -3.523697e-02  1.909878e-02 -0.0561113601
## Creatinine_T0      4.145564e-02 -4.036205e-02 -8.986026e-02  0.0391727113
## Kynurenine_T0     -3.001029e-02 -7.495730e-03  1.563664e-02 -0.0049806896
## Putrescine_T0     -1.125457e-01 -5.294667e-02 -1.150327e-01  0.1299070497
## Sarcosine_T0       2.577060e-02 -7.858692e-03  3.930989e-03 -0.0291981994
## Serotonin_T0      -7.011672e-02 -3.742605e-03 -1.560111e-01 -0.0535186815
## Taurine_T0        -3.442256e-02 -9.651421e-02 -2.288664e-02  0.0151027371
## SDMA_T0           -1.399584e-02 -9.195732e-03  3.911046e-03  0.0024730178
## C0_T0              1.654919e-02  5.223791e-02 -3.086012e-02  0.0151413487
## C2_T0             -1.431441e-01 -2.606211e-02 -1.353798e-01  0.0283405831
## C3.OH_T0          -6.812222e-04  4.610043e-03  6.250858e-04  0.0058813809
## C6..C4.1.DC._T0   -6.419746e-02 -5.366519e-03 -1.320337e-02 -0.1685608018
## C5.DC..C6.OH._T0   1.611611e-02 -7.544905e-02 -1.006158e-01 -0.0291494694
## C7.DC_T0           6.002286e-02 -6.292028e-02 -1.029778e-01 -0.0002397127
## C8_T0              2.888853e-03 -1.244414e-03  6.518157e-03  0.0052447631
## C10_T0            -1.186022e-03  7.304987e-03  8.860856e-04  0.0061996843
## C10.1_T0          -3.636043e-04  5.037831e-03  1.965485e-03  0.0074673781
## C10.2_T0          -1.052217e-03  4.058030e-03  5.352966e-03  0.0046641190
## C14.1_T0          -3.572563e-03  5.335782e-03  6.369721e-04  0.0057146188
## C14.2_T0          -1.742656e-03  4.816527e-03  3.146648e-03  0.0045916306
## C16.1_T0          -1.613067e-03  4.059117e-03  1.705855e-03  0.0052273025
## C16.2_T0          -1.350209e-03  2.839213e-03  3.101445e-03  0.0066911939
## C16.2.OH_T0       -1.113140e-03  4.432617e-03  3.547203e-03  0.0069559057
## C18.1_T0          -8.887285e-04  4.405269e-03 -4.011857e-04  0.0058992562
## C18.1.OH_T0       -6.923796e-04  3.982070e-03  2.795359e-03  0.0065296722
## C18.2_T0          -1.696049e-03  3.243124e-03  1.549722e-03  0.0058095430
## lysoPC.a.C16.0_T0  2.278103e-02  3.470751e-02  1.907807e-02  0.0565756587
## lysoPC.a.C16.1_T0  5.215331e-03  1.723693e-02 -2.928816e-03  0.0201107987
## lysoPC.a.C17.0_T0  1.466659e-02  1.351754e-02 -1.274371e-02  0.0004415377
## lysoPC.a.C18.0_T0  6.222894e-03  5.908994e-02  3.042882e-02  0.0325518044
## lysoPC.a.C18.1_T0  3.717808e-02  6.179052e-02  1.686039e-02  0.0224330796
## lysoPC.a.C18.2_T0 -3.313775e-02  1.691171e-02  3.275115e-03 -0.0568513376
## lysoPC.a.C20.3_T0  2.542746e-02  4.158134e-02  2.307099e-02  0.0209903640
## lysoPC.a.C20.4_T0  1.982372e-02  5.222527e-02  1.586266e-02  0.0125064474
## lysoPC.a.C24.0_T0 -1.261630e-03  6.594459e-03  8.492883e-03  0.0062241585
## lysoPC.a.C26.0_T0 -9.971934e-02 -2.590560e-02  1.028428e-02  0.1079828686
## lysoPC.a.C26.1_T0 -5.221029e-03  1.109469e-03  4.170257e-03  0.0042889323
## lysoPC.a.C28.0_T0 -9.957710e-02 -9.974875e-02  8.047244e-02  0.1100546944
## lysoPC.a.C28.1_T0 -2.158756e-04  2.867363e-03  3.952010e-03  0.0050789126
## PC.aa.C24.0_T0    -6.464941e-02  2.890112e-02  3.873059e-02  0.0953659065
## PC.aa.C28.1_T0    -1.818031e-03  2.466749e-02  9.570470e-03 -0.0166098239
## PC.aa.C30.0_T0     1.346791e-02 -1.762702e-02  3.542120e-02 -0.0004891281
## PC.aa.C32.0_T0    -2.845990e-02 -3.344366e-02  4.020143e-02  0.0100132286
## PC.aa.C32.1_T0    -2.721617e-03 -5.717273e-02  1.302132e-02  0.0274397083
## PC.aa.C32.3_T0    -1.326742e-03  1.358822e-03 -1.202298e-03  0.0057162638
## PC.aa.C34.1_T0     8.268198e-02 -1.503835e-02 -2.321759e-02  0.0185427051
## PC.aa.C34.2_T0     3.824176e-03 -6.324836e-02 -2.093637e-02 -0.0419569559
## PC.aa.C34.3_T0     7.146951e-03 -3.989076e-02 -4.832858e-02 -0.0048329895
## PC.aa.C34.4_T0     1.155246e-02  3.241958e-04  8.249238e-03  0.0098205652
## PC.aa.C36.0_T0    -1.022778e-04 -2.792512e-02  1.117922e-02 -0.0045563000
## PC.aa.C36.1_T0     5.637854e-02  8.942451e-03  2.563754e-02  0.0075930254
## PC.aa.C36.2_T0     2.188382e-02 -1.981692e-04 -5.062547e-02 -0.0430179492
## PC.aa.C36.3_T0     3.775965e-02  1.990245e-02 -2.328135e-02  0.0179392364
## PC.aa.C36.4_T0     1.352496e-02  3.735576e-02 -5.288880e-02  0.0007457426
## PC.aa.C36.5_T0     3.690502e-02 -6.380547e-02 -6.652613e-02 -0.0423527726
## PC.aa.C38.0_T0     1.822822e-03 -3.480853e-02  1.311450e-02 -0.0102994483
## PC.aa.C38.1_T0     1.016866e-02 -4.999918e-02 -1.873934e-02 -0.0031285638
## PC.aa.C38.3_T0     4.942999e-02  2.272257e-02 -1.322075e-02  0.0567563443
## PC.aa.C38.4_T0     2.040964e-02  6.478635e-02 -4.044923e-02  0.0037376541
## PC.aa.C38.5_T0     2.376327e-02  4.874092e-02 -3.065225e-02  0.0001071658
## PC.aa.C38.6_T0     3.762915e-02  1.755173e-02  1.979482e-03  0.0252780025
## PC.aa.C40.1_T0    -1.429707e-02  4.481177e-02  1.101069e-01 -0.0937719027
## PC.aa.C40.2_T0     1.599586e-03 -4.077868e-03  8.102805e-03 -0.0056586583
## PC.aa.C40.3_T0     1.037417e-03 -4.530252e-03  8.296582e-03 -0.0051231970
## PC.aa.C40.4_T0    -1.234193e-02  4.071040e-03  3.317557e-02  0.0016014422
## PC.aa.C40.5_T0    -1.404386e-02  1.236360e-02  4.339190e-02 -0.0118559984
## PC.aa.C40.6_T0     1.963705e-02 -9.249186e-03  5.693849e-02  0.0042173881
## PC.aa.C42.0_T0     8.984994e-04 -1.034848e-02  6.600593e-03 -0.0076405936
## PC.aa.C42.1_T0     1.250003e-03 -2.591078e-03  3.312594e-03  0.0008810293
## PC.aa.C42.2_T0    -1.105136e-03 -2.902180e-03  5.553019e-03 -0.0004162862
## PC.aa.C42.4_T0    -2.523066e-03  5.130427e-04  5.221071e-03  0.0016085183
## PC.aa.C42.5_T0    -1.435327e-03  1.896476e-03  7.082665e-03  0.0011515799
## PC.aa.C42.6_T0    -6.208633e-02  6.935339e-03 -2.501179e-02  0.0851544280
## PC.ae.C30.0_T0    -5.512167e-04  1.770539e-03  6.392285e-03  0.0033765323
## PC.ae.C32.1_T0    -1.808206e-02 -2.399661e-02 -8.754739e-03 -0.0118085882
## PC.ae.C32.2_T0    -5.741194e-03 -2.047457e-03 -3.641724e-03  0.0015824449
## PC.ae.C34.0_T0    -6.614384e-03 -6.869939e-03  8.029580e-03 -0.0003631068
## PC.ae.C34.1_T0     2.221788e-02 -3.660257e-02 -1.928058e-02 -0.0225323733
## PC.ae.C34.2_T0     3.844037e-03 -6.342241e-02 -5.083556e-02 -0.0576134113
## PC.ae.C34.3_T0    -2.562429e-02 -1.741075e-02 -1.130061e-02 -0.0639319620
## PC.ae.C36.0_T0     2.353337e-03 -3.107331e-03  1.148635e-02  0.0005434930
## PC.ae.C36.1_T0     1.488635e-02 -1.557179e-02 -3.849856e-03 -0.0180860090
## PC.ae.C36.2_T0     2.015028e-02 -5.986327e-02 -4.856170e-02 -0.0598486074
## PC.ae.C36.3_T0     4.066390e-03 -2.114421e-02 -3.575580e-02 -0.0258423539
## PC.ae.C36.4_T0    -2.006872e-02 -3.696623e-02 -2.558443e-03 -0.0165274609
## PC.ae.C36.5_T0    -5.371087e-02 -4.403529e-02  1.752392e-02  0.0062780592
## PC.ae.C38.0_T0     1.222305e-02 -3.775995e-03 -2.804655e-03  0.0051052381
## PC.ae.C38.2_T0    -3.072747e-03 -1.249479e-02  5.878003e-03 -0.0192193673
## PC.ae.C38.3_T0     2.730203e-02 -8.889442e-03 -5.855107e-03 -0.0041369090
## PC.ae.C38.4_T0     2.971129e-03 -4.799703e-03 -5.693192e-02 -0.0246223841
## PC.ae.C38.5_T0    -2.358203e-02  1.194882e-02 -2.854795e-02 -0.0161675684
## PC.ae.C38.6_T0    -1.010720e-02 -1.941612e-02 -3.221375e-03  0.0136858404
## PC.ae.C40.1_T0     2.719211e-03 -1.724733e-02  1.796234e-02 -0.0028604139
## PC.ae.C40.2_T0     5.546202e-03 -4.186633e-03 -2.766600e-03 -0.0118616515
## PC.ae.C40.3_T0     1.132596e-02 -9.502117e-03 -2.214264e-03 -0.0063642361
## PC.ae.C40.4_T0     7.051962e-03 -1.712420e-02  1.028350e-03 -0.0218775183
## PC.ae.C40.5_T0     1.090023e-03 -8.850024e-03 -3.777063e-03 -0.0132708760
## PC.ae.C40.6_T0     3.451749e-03 -9.588795e-03 -7.879364e-03 -0.0106839541
## PC.ae.C42.1_T0     9.621177e-04 -2.254911e-03  9.016444e-03  0.0015389183
## PC.ae.C42.2_T0    -2.931984e-04 -2.886981e-03  6.091558e-03 -0.0059233274
## PC.ae.C42.3_T0     5.585012e-03 -1.320907e-02  4.804788e-03 -0.0084697631
## PC.ae.C42.4_T0     3.563536e-04 -1.136190e-02  1.564971e-03 -0.0155894620
## PC.ae.C42.5_T0     1.329867e-02 -2.274850e-02 -1.101669e-02 -0.0285630320
## PC.ae.C44.3_T0    -8.778543e-04 -7.408456e-04  4.556560e-03  0.0009401359
## PC.ae.C44.4_T0     3.995532e-03 -6.548327e-03  1.960472e-03  0.0002676674
## PC.ae.C44.5_T0     1.998637e-02 -4.218418e-02 -1.761055e-02 -0.0384873370
## PC.ae.C44.6_T0     5.805583e-03 -2.563532e-02  2.212979e-03 -0.0246109932
## SM..OH..C14.1_T0  -4.195609e-03  1.846113e-02 -4.732172e-02  0.0048966577
## SM..OH..C16.1_T0   6.674251e-03  1.194834e-02 -2.204807e-02  0.0024676850
## SM..OH..C22.1_T0   4.085128e-02 -5.979411e-03 -8.295999e-02  0.0086728371
## SM..OH..C22.2_T0   2.384887e-02  1.488855e-02 -8.334611e-02  0.0129637300
## SM..OH..C24.1_T0   5.236532e-03  5.497596e-03 -4.210537e-03  0.0058197175
## SM.C16.0_T0       -2.045637e-02  2.536576e-02  4.600780e-05  0.0025033478
## SM.C16.1_T0       -2.019508e-02  4.337024e-02 -8.567100e-02  0.0029739792
## SM.C18.0_T0       -1.366248e-03  3.866667e-03 -8.748730e-02 -0.0299372878
## SM.C18.1_T0        9.370472e-03  1.187689e-02 -1.421612e-01  0.0186642033
## SM.C20.2_T0        8.933152e-04  2.857140e-03  4.396774e-04  0.0077166783
## SM.C24.0_T0        3.117807e-02  1.804560e-02 -1.401395e-03  0.0020127468
## SM.C24.1_T0        5.457287e-02  2.286903e-03 -3.772816e-02 -0.0125704548
## MEDDM_T2          -9.497074e-04  3.383742e-03  3.413898e-03  0.0068377480
## MEDCOL_T2         -9.497074e-04  3.383742e-03  3.413898e-03  0.0068377480
## MEDINF_T2          5.985861e-03  9.355440e-04  1.464672e-02  0.0036884320
## MEDHTA_T2          1.277765e-03 -1.503679e-02  8.271847e-03  0.0027388128
## GLU_T2            -2.073921e-02 -7.180508e-03  3.304928e-02  0.0005226389
## INS_T2             8.462513e-02 -2.205072e-02 -1.710465e-03  0.0440111141
## HOMA_T2            4.942707e-02 -2.877420e-03  1.026834e-02  0.0403512113
## HBA1C_T2          -7.737721e-03  8.366559e-03  4.671216e-03 -0.0169795052
## HBA1C.mmol.mol_T2 -1.564479e-02  2.861639e-03  4.261627e-05 -0.0669343859
## PESO_T2            4.216915e-02 -1.815537e-02 -4.663942e-02 -0.0350836507
## bmi_T2             3.901522e-02 -9.867025e-03  1.922719e-03 -0.0047823405
## CC_T2              3.047670e-03  2.089774e-03  4.416354e-03  0.0065567280
## CINT_T2            7.540875e-02 -1.496831e-02 -3.787001e-02 -0.0087269955
## CAD_T2             1.672855e-02  2.142761e-02 -3.182390e-02 -0.0174488755
## TAD_T2             2.723325e-02 -2.757661e-02  1.031454e-03  0.0095987763
## TAS_T2             3.251339e-02  8.279241e-02 -3.994126e-02  0.0335271966
## TG_T2             -5.707769e-02 -4.866613e-02 -5.017962e-02  0.0274140711
## COL_T2            -5.430221e-02 -6.057967e-02  2.485863e-02  0.0002265004
## LDL_T2            -5.051644e-02 -4.899702e-02  5.809641e-02  0.0109682392
## HDL_T2             3.212886e-03 -6.186067e-02 -3.898585e-02  0.0464712754
## VLDL_T2           -7.685339e-03 -1.819517e-02 -1.139976e-02  0.1142620980
## PCR_T2            -9.967722e-03  7.132866e-02  1.118727e-01  0.0338669754
## LEP_T2            -8.733534e-03  1.803437e-02  7.877823e-02  0.0080273201
## ADIPO_T2          -4.398614e-02  1.538199e-02 -6.586366e-03  0.0336526987
## GOT_T2             4.888928e-02 -7.108459e-04 -7.385087e-02  0.0053225352
## GPT_T2             2.241124e-02 -1.074990e-01 -9.630821e-02 -0.0595542772
## GGT_T2            -8.311785e-02 -6.240225e-02 -2.212471e-02  0.0377337374
## URICO_T2           9.150903e-02 -3.284151e-02 -5.202346e-02  0.0510883437
## CREAT_T2           1.066616e-03 -7.678323e-04  3.573025e-03 -0.0010781735
## UREA_T2            9.051390e-02 -5.279393e-02  2.382425e-03 -0.0061993180
## HIERRO_T2         -1.143768e-01 -1.660937e-02  1.972413e-02  0.0083488953
## TRANSF_T2         -4.716083e-02 -1.090264e-01  1.367580e-02  0.0428983516
## FERR_T2            9.510143e-02 -3.940589e-03 -3.832529e-03 -0.0446729441
## Ile_T2            -3.432251e-03  3.190502e-02 -2.648356e-02  0.0302927397
## Leu_T2             1.994781e-02  3.840470e-04 -1.515197e-02  0.0779481106
## Val_T2             4.633080e-02 -2.075093e-02 -8.263372e-03  0.0364420420
## Ala_T2            -4.516590e-02 -2.129542e-02  4.458338e-03  0.0181030634
## Pro_T2            -8.426322e-03  1.462293e-02 -7.022733e-02 -0.0774286231
## Gly_T2            -9.081203e-02 -2.575842e-02  3.705112e-04 -0.0661071738
## Ser_T2            -2.445377e-02  7.810635e-03 -3.148286e-02 -0.0646681130
## Trp_T2             3.255063e-02 -2.255854e-02  5.524468e-02 -0.0005555078
## Phe_T2             1.816335e-02  4.373714e-02 -1.176163e-02  0.0104061992
## Met_T2            -6.401129e-03 -4.302871e-02  2.220155e-03  0.0342064155
## Orn_T2             1.112678e-01 -1.307602e-02 -3.381062e-03  0.0254676889
## Arg_T2             2.748280e-02 -7.882931e-03  5.826219e-02 -0.0015068535
## His_T2             4.428325e-02 -7.150117e-02 -6.020504e-03  0.0444248413
## Asn_T2             8.190224e-03  5.287786e-03  3.651508e-02 -0.0188816045
## Asp_T2             4.515307e-02 -8.438275e-02 -3.695025e-02  0.0247181677
## Glu_T2             4.730526e-02 -5.361973e-02 -9.813538e-03  0.0044471591
## Gln_T2             5.680365e-02 -6.222405e-02 -2.521032e-02  0.0199807989
## Cit_T2             1.033802e-01 -1.897749e-02  8.246520e-04 -0.0930729717
## Tyr_T2            -2.389599e-02  6.744119e-03 -3.442682e-02  0.0666316706
## Thr_T2             5.188428e-02 -5.405602e-02 -6.299646e-02  0.0534324874
## Lys_T2            -3.102876e-02  2.182606e-02 -2.077196e-03  0.0930420241
## Creatinine_T2      3.730509e-02 -7.413865e-02  2.260438e-02 -0.0539056101
## Kynurenine_T2      7.304717e-03  1.964796e-02  2.883168e-02 -0.0429064216
## Putrescine_T2     -1.151153e-01  1.110171e-01  8.747377e-02 -0.0038149203
## Sarcosine_T2      -1.727606e-02 -6.030211e-02 -4.673680e-02  0.0298182280
## Serotonin_T2       1.536161e-02  1.002270e-01  5.471002e-02  0.0895954338
## Taurine_T2        -1.540692e-01  2.733487e-01 -1.027343e-01 -0.0483065382
## SDMA_T2           -4.069087e-03  2.245293e-02  2.665943e-02  0.0075094967
## C0_T2             -3.052908e-02 -5.246276e-02  3.348664e-02 -0.0554572502
## C2_T2              4.425609e-02 -8.922361e-03 -2.945755e-03 -0.0078255954
## C3.OH_T2           1.287496e-03  7.805327e-04  9.359364e-03  0.0029951954
## C6..C4.1.DC._T2   -7.680802e-02  8.104879e-02  8.834765e-02  0.0268625274
## C5.DC..C6.OH._T2   2.851453e-02  4.892637e-02  2.142828e-02 -0.1246763115
## C7.DC_T2           2.445334e-02 -3.904791e-02  1.391596e-01 -0.0078091005
## C8_T2             -6.635091e-04 -8.091426e-03  1.330632e-02 -0.0020952806
## C10_T2            -2.217841e-03 -4.098693e-03  6.820634e-03 -0.0094090812
## C10.1_T2          -2.106094e-03  7.590579e-04  6.609297e-03  0.0031867687
## C10.2_T2          -1.467959e-03  1.036223e-03  6.360983e-03  0.0021386800
## C14.1_T2           1.622729e-03  1.757812e-03  3.946817e-03  0.0017643735
## C14.2_T2          -8.518796e-04  7.026953e-04  3.849890e-03  0.0048342342
## C16.1_T2          -5.563015e-04  1.276138e-03  4.775914e-03  0.0039011183
## C16.2_T2          -7.623318e-04  2.703099e-03  3.908874e-03  0.0055918800
## C16.2.OH_T2       -7.696037e-04  2.415227e-03  3.601662e-03  0.0071768503
## C18.1_T2           1.469156e-03  4.629146e-03  1.945267e-03  0.0061236936
## C18.1.OH_T2       -3.174461e-04  1.289509e-03  4.215547e-03  0.0063532258
## C18.2_T2           5.940853e-04 -1.934315e-03  4.137495e-03  0.0071486699
## lysoPC.a.C14.0_T2  6.803812e-03 -8.090128e-02 -4.503701e-02 -0.0231883311
## lysoPC.a.C16.0_T2 -3.701925e-02 -9.423080e-03 -6.847138e-02 -0.0370137903
## lysoPC.a.C16.1_T2 -5.372858e-02 -2.339875e-03 -1.889563e-02 -0.0130883092
## lysoPC.a.C17.0_T2 -1.436626e-02 -3.248140e-03 -1.094789e-02  0.0075703485
## lysoPC.a.C18.0_T2 -2.098959e-02 -5.391135e-03 -2.694524e-02 -0.0300965114
## lysoPC.a.C18.1_T2  5.153069e-02  2.443475e-03 -4.721459e-02 -0.0657606887
## lysoPC.a.C18.2_T2 -5.745338e-03 -3.638285e-02 -5.629656e-02  0.0184781806
## lysoPC.a.C20.3_T2  3.459489e-02  3.546131e-02  1.523237e-03 -0.0426790672
## lysoPC.a.C20.4_T2  5.167493e-02  3.759927e-02 -6.804761e-02 -0.0969485815
## lysoPC.a.C24.0_T2 -4.386681e-03  3.879069e-03  4.846344e-03 -0.0021809560
## lysoPC.a.C26.0_T2 -5.954251e-02  3.745744e-02 -6.116975e-02 -0.0332570654
## lysoPC.a.C26.1_T2 -4.402748e-03  5.526351e-03  1.698182e-03 -0.0040603922
## lysoPC.a.C28.0_T2  3.212886e-02  8.140669e-02 -1.057765e-02 -0.1420366497
## lysoPC.a.C28.1_T2 -6.352877e-03  1.145286e-02 -2.009197e-03 -0.0042693780
## PC.aa.C24.0_T2     6.322546e-02  4.430853e-02 -3.375443e-02 -0.1611950298
## PC.aa.C28.1_T2    -1.938914e-02 -1.467351e-02  2.126706e-03  0.0044635550
## PC.aa.C30.0_T2    -1.179557e-02 -1.217926e-02 -1.044601e-03  0.0164795979
## PC.aa.C32.0_T2    -2.013819e-02 -8.895564e-03  3.510552e-02  0.0127174866
## PC.aa.C32.1_T2    -7.375952e-02 -1.513784e-02 -2.266809e-02 -0.0181123749
## PC.aa.C32.3_T2    -4.557442e-03  6.232130e-03  1.571862e-03  0.0048479034
## PC.aa.C34.1_T2     3.576762e-03  4.945200e-03  4.156478e-02 -0.0382652513
## PC.aa.C34.2_T2    -7.926799e-02 -2.980601e-02  9.868852e-03  0.0590806626
## PC.aa.C34.3_T2    -8.244041e-02  1.024259e-03  2.002537e-02 -0.0031503799
## PC.aa.C34.4_T2    -2.223735e-03  3.477715e-03  5.020362e-03  0.0051846116
## PC.aa.C36.0_T2    -2.369750e-03  1.268301e-02 -2.845645e-03 -0.0003478142
## PC.aa.C36.1_T2    -1.641381e-02  1.274590e-02  7.593331e-02  0.0442317392
## PC.aa.C36.2_T2    -6.692101e-02 -1.686672e-02  2.005941e-02  0.0331721558
## PC.aa.C36.3_T2    -6.038746e-02  4.854008e-02  4.816142e-02  0.0028888238
## PC.aa.C36.4_T2    -2.423422e-02  6.600755e-02  2.668116e-02 -0.0783385531
## PC.aa.C36.5_T2     8.177455e-03 -2.987802e-02 -2.744422e-02  0.0328467475
## PC.aa.C38.0_T2     4.486381e-03  4.297527e-03  1.346417e-02  0.0072223082
## PC.aa.C38.1_T2     4.176888e-03  4.362837e-02 -4.630653e-02  0.0325082637
## PC.aa.C38.3_T2    -2.108277e-02  3.390138e-02  3.620842e-02 -0.0587140879
## PC.aa.C38.4_T2    -1.930091e-02  1.507074e-02 -1.199089e-03 -0.0949230028
## PC.aa.C38.5_T2    -2.710126e-02 -1.785946e-02  2.745041e-03 -0.0647733528
## PC.aa.C38.6_T2    -5.814953e-02 -1.555811e-02  7.543406e-03 -0.0631151153
## PC.aa.C40.1_T2     6.523215e-02 -7.264122e-03  7.110316e-02  0.0745539535
## PC.aa.C40.2_T2    -2.180065e-03  2.131241e-02 -6.923877e-03 -0.0017672892
## PC.aa.C40.3_T2    -3.149615e-03  2.052013e-02 -1.099408e-03 -0.0042131015
## PC.aa.C40.4_T2    -1.556660e-02  2.378500e-03  1.631785e-02 -0.0127573741
## PC.aa.C40.5_T2    -3.277791e-02 -1.614803e-02  1.431656e-02 -0.0228463819
## PC.aa.C40.6_T2    -7.671306e-02 -2.544723e-02 -1.070136e-02 -0.0328447472
## PC.aa.C42.0_T2    -1.184692e-03  2.649861e-03 -3.605943e-03 -0.0014584986
## PC.aa.C42.1_T2    -1.507257e-03  5.771683e-03 -6.311264e-05  0.0012316930
## PC.aa.C42.2_T2    -1.998675e-03  8.105359e-03 -1.643521e-03  0.0037105637
## PC.aa.C42.4_T2    -1.115497e-03  6.336128e-03  7.543580e-04  0.0038326119
## PC.aa.C42.5_T2    -1.751277e-04  4.856493e-03  1.970322e-03  0.0032286153
## PC.aa.C42.6_T2     3.407055e-02  7.616336e-02 -1.718157e-02 -0.0135188090
## PC.ae.C30.0_T2    -7.723492e-02  5.403360e-02 -1.065534e-01  0.0697837733
## PC.ae.C32.1_T2     6.237234e-03  4.968595e-03  3.877524e-03  0.0253393794
## PC.ae.C32.2_T2    -4.923509e-03  5.890310e-03 -8.503143e-04  0.0071969950
## PC.ae.C34.0_T2    -1.434132e-03  1.300537e-03  7.262205e-03  0.0131313594
## PC.ae.C34.1_T2    -8.318771e-03  1.297130e-02  1.995302e-02  0.0238103232
## PC.ae.C34.2_T2     4.836924e-03  4.906140e-03  2.819383e-03  0.0170791886
## PC.ae.C34.3_T2     2.705724e-03  1.199169e-02 -5.090060e-03 -0.0020562300
## PC.ae.C36.0_T2     3.384367e-03  6.456238e-03  1.478141e-02  0.0104596348
## PC.ae.C36.1_T2    -7.228107e-03  5.004675e-02 -8.823947e-03 -0.0175763976
## PC.ae.C36.2_T2    -4.097739e-02 -5.887170e-05 -1.230963e-02  0.0313303297
## PC.ae.C36.3_T2     9.012759e-03  1.119082e-02  4.672158e-03  0.0051662073
## PC.ae.C36.4_T2    -1.779118e-03  8.126459e-04  3.395399e-02  0.0192807828
## PC.ae.C36.5_T2     1.215462e-02  1.259713e-02  3.097793e-02  0.0255529375
## PC.ae.C38.0_T2    -2.180825e-02 -8.235758e-03 -9.692936e-04  0.0018291391
## PC.ae.C38.2_T2    -7.006499e-03  2.814630e-02 -1.787792e-02  0.0166377041
## PC.ae.C38.3_T2    -1.343737e-02  4.683908e-02 -1.094230e-02 -0.0109095092
## PC.ae.C38.4_T2     1.041735e-02  2.470569e-02  2.914182e-02 -0.0060009408
## PC.ae.C38.5_T2     1.457104e-02  9.201464e-03  4.902436e-02 -0.0047561374
## PC.ae.C38.6_T2    -1.563058e-02  1.570798e-02  1.866775e-02  0.0056428757
## PC.ae.C40.1_T2    -4.058653e-03  8.632019e-03 -3.336651e-03 -0.0086592244
## PC.ae.C40.2_T2    -1.397320e-02  1.849790e-02 -2.375493e-03  0.0071456971
## PC.ae.C40.3_T2    -4.621150e-03  2.807497e-02 -1.629327e-02 -0.0025852673
## PC.ae.C40.4_T2    -5.027669e-04  1.765373e-02 -2.669149e-04 -0.0052087820
## PC.ae.C40.5_T2    -8.791269e-04  7.508333e-03 -4.325849e-03 -0.0088893027
## PC.ae.C40.6_T2    -4.236543e-03  3.781812e-04  9.527653e-03 -0.0028663039
## PC.ae.C42.1_T2    -2.215029e-03  2.041789e-02  1.220151e-03 -0.0030558292
## PC.ae.C42.2_T2    -2.110335e-04  8.841618e-03 -3.177140e-03  0.0012895078
## PC.ae.C42.3_T2    -5.185497e-03  3.960469e-03 -5.340424e-03 -0.0001250811
## PC.ae.C42.4_T2    -1.623012e-03 -2.409758e-03  3.263416e-03  0.0024303971
## PC.ae.C42.5_T2     1.202924e-02 -1.091861e-02 -7.109041e-03 -0.0108095499
## PC.ae.C44.3_T2     1.316009e-02 -3.370845e-02 -4.539936e-03 -0.0115199453
## PC.ae.C44.4_T2     2.566196e-03  9.633982e-04  4.271703e-04  0.0044371295
## PC.ae.C44.5_T2     2.186158e-02 -4.127807e-02 -1.360610e-02 -0.0041717718
## PC.ae.C44.6_T2    -1.652568e-04 -1.919990e-02 -1.720654e-02 -0.0037327064
## SM..OH..C14.1_T2  -3.650526e-02  1.492696e-02 -1.666299e-02  0.0210879854
## SM..OH..C16.1_T2  -1.975400e-02  5.277373e-03 -5.144316e-03  0.0119512549
## SM..OH..C22.1_T2   4.162315e-03 -2.455377e-02  2.417644e-03  0.0041008800
## SM..OH..C22.2_T2  -1.878745e-02  4.352088e-03 -2.584616e-02 -0.0132039081
## SM..OH..C24.1_T2  -5.674997e-03 -2.291561e-03  4.195809e-03  0.0111671399
## SM.C16.0_T2       -4.920302e-02  1.695097e-03  1.353241e-02 -0.0217303224
## SM.C16.1_T2       -3.567154e-02  2.097960e-02 -5.100684e-02 -0.0462138625
## SM.C18.0_T2       -1.146853e-01  2.631583e-02 -4.121353e-02 -0.0046123083
## SM.C18.1_T2       -7.457914e-02  2.587863e-02 -8.410673e-02 -0.0332386421
## SM.C20.2_T2       -6.060613e-03  3.535631e-03 -1.326018e-03  0.0077175477
## SM.C24.0_T2       -1.724191e-02 -3.232030e-02  3.490383e-02 -0.0042643587
## SM.C24.1_T2       -4.969681e-02 -2.673997e-02 -1.657483e-04 -0.0308045617
## MEDDM_T4           4.782671e-03  4.716376e-03  5.140205e-03  0.0079096462
## MEDCOL_T4          8.695962e-03  1.132873e-02 -1.675890e-02  0.0150345502
## MEDINF_T4         -9.081027e-04  4.714583e-03  1.121098e-02  0.0200309188
## MEDHTA_T4          5.259192e-03  2.891223e-03 -2.538751e-02  0.0112701013
## GLU_T4            -4.463627e-02  9.156790e-02 -3.587839e-02 -0.0359284893
## INS_T4            -1.269570e-01  6.766797e-02  6.203589e-02  0.1846963255
## HOMA_T4           -5.338236e-02  4.084692e-02  1.423498e-02  0.0640151838
## HBA1C_T4          -3.927332e-03  2.335918e-02  1.842397e-02 -0.0208772330
## HBA1C.mmol.mol_T4 -4.114109e-04  5.286301e-02  4.636535e-02 -0.0715666908
## PESO_T4            2.177502e-02 -3.107971e-02 -1.310314e-02 -0.0073741916
## bmi_T4             2.269799e-02 -1.905624e-02  3.128140e-02  0.0310240860
## CC_T4             -1.748899e-04  4.890503e-03  1.039700e-02  0.0038060158
## CINT_T4            7.169335e-02 -4.503607e-02 -7.565221e-03  0.0372748515
## CAD_T4             2.892002e-02 -1.533444e-02 -3.285460e-02  0.0134064072
## TAD_T4             4.330325e-02  9.391807e-03 -6.667919e-02  0.0061577043
## TAS_T4             2.976380e-02  6.439689e-02 -6.126094e-02  0.0198780016
## TG_T4             -5.468188e-02 -4.062371e-02 -4.458670e-02 -0.0357340204
## COL_T4             2.725478e-02 -2.373873e-02 -6.296225e-03 -0.0449906969
## LDL_T4             3.783804e-02 -2.219554e-02 -4.666023e-03 -0.0036584772
## HDL_T4             6.407029e-02 -9.997140e-03 -1.582140e-02 -0.0937957110
## VLDL_T4           -5.941315e-02 -7.196396e-02  4.757700e-03 -0.0244830002
## PCR_T4             1.231865e-01 -7.841961e-02 -2.317822e-02  0.0705140991
## LEP_T4             4.089542e-02 -2.276415e-02  1.033019e-01  0.0821985137
## ADIPO_T4           1.079087e-03 -2.328511e-02  2.119844e-02  0.0410811936
## GOT_T4             3.490688e-02  7.376572e-02 -6.419714e-02 -0.0973078840
## GPT_T4            -1.683782e-02  2.631425e-02  1.111403e-04 -0.1110012695
## GGT_T4            -3.405185e-03  5.853112e-02  2.518190e-01 -0.0949821740
## URICO_T4           3.069141e-02 -8.183821e-02 -2.334029e-03  0.0001807418
## CREAT_T4          -6.805653e-03  2.807470e-03 -3.554776e-03 -0.0027573625
## UREA_T4           -5.684494e-03  7.531597e-04  1.037383e-02 -0.0911625547
## HIERRO_T4          3.856863e-02 -1.948759e-02  6.531951e-02 -0.0150107394
## TRANSF_T4         -2.371737e-03 -1.071210e-01  1.062154e-01  0.0728046168
## FERR_T4            2.795304e-02 -2.050520e-02 -1.001522e-01 -0.0208526000
## Ile_T4            -6.599218e-02  4.829631e-03 -4.413209e-03 -0.0123536505
## Leu_T4            -8.735445e-02  3.069254e-02 -1.995210e-02 -0.0514758687
## Val_T4            -4.694382e-02  2.584725e-02  9.598329e-03 -0.0140547850
## Ala_T4            -3.382306e-02 -5.948897e-02 -5.017289e-02  0.0526945679
## Pro_T4            -2.600847e-02 -2.870149e-02 -6.675291e-03  0.0350736543
## Gly_T4            -5.016845e-02  2.639476e-02 -3.091378e-02 -0.0225632993
## Ser_T4             6.710656e-02  6.455897e-02  5.908807e-02 -0.0442595247
## Trp_T4             2.212341e-02  1.004609e-02  5.918550e-03 -0.0285454370
## Phe_T4            -2.979167e-02  1.878319e-02  7.607107e-03 -0.0539140239
## Met_T4            -6.548029e-02 -4.510472e-03  8.608013e-03 -0.0068917692
## Orn_T4             6.067697e-02  4.917542e-02  7.311960e-02 -0.0035694299
## Arg_T4            -6.202662e-02 -7.480640e-02  2.503443e-02  0.0630196824
## His_T4            -5.898161e-02 -1.615150e-02 -3.734526e-02 -0.0291528413
## Asn_T4            -1.122411e-02 -8.712497e-03  2.729503e-02 -0.0086609146
## Asp_T4            -1.181088e-01 -1.154564e-01  2.389522e-01 -0.0859156310
## Glu_T4             3.270226e-03  1.028338e-02  5.644548e-02  0.0267126176
## Gln_T4             7.173932e-02  9.916118e-02 -2.712640e-02 -0.0286939451
## Cit_T4            -1.595386e-02  5.423099e-02  3.864010e-04  0.0980877968
## Tyr_T4            -1.329079e-02 -2.054751e-03  5.745343e-03 -0.0391361647
## Thr_T4            -3.173802e-02 -2.650430e-02  5.093517e-02  0.0486170835
## Lys_T4            -7.162791e-03 -4.781387e-02 -1.458812e-02  0.0431618047
## Creatinine_T4     -4.015297e-02 -3.599387e-03 -6.380839e-02 -0.0383869044
## Kynurenine_T4      2.841984e-02  1.118974e-01 -4.468500e-03  0.1801657829
## Putrescine_T4     -4.242641e-02  8.432148e-02 -1.564256e-02 -0.0247173531
## Sarcosine_T4      -8.916247e-02 -5.297631e-02 -3.223404e-02  0.0792041064
## Serotonin_T4       2.458545e-02  1.055879e-01  3.397682e-02  0.1117828535
## Taurine_T4         9.693296e-02  3.188829e-02  4.882934e-02  0.0489096220
## SDMA_T4            1.868387e-03  1.211198e-02  8.186285e-03  0.0060413111
## C0_T4             -4.597886e-02  5.186567e-02  7.498962e-02 -0.0281683998
## C2_T4             -7.066272e-02  8.701931e-02  1.030999e-02 -0.0943430068
## C3.OH_T4          -3.213324e-03  7.632071e-03  9.306951e-03  0.0028103856
## C6..C4.1.DC._T4    5.911302e-02  9.378016e-02  2.626646e-02  0.0237228584
## C5.DC..C6.OH._T4  -2.165011e-02 -6.936770e-02 -6.489522e-03  0.1151802097
## C7.DC_T4          -9.662332e-02 -1.204483e-01  1.291949e-01 -0.0072158090
## C8_T4             -1.295941e-02  5.080057e-03  9.689346e-03  0.0027930813
## C10_T4            -8.806188e-03  1.240695e-03  3.228017e-03  0.0031140466
## C10.1_T4          -4.643128e-03  2.348777e-03  4.382214e-03  0.0063529403
## C10.2_T4          -2.815765e-03  2.254311e-03  5.235627e-03  0.0064031630
## C14.1_T4          -5.565329e-03  3.528273e-03  4.179311e-03  0.0042048575
## C14.2_T4          -4.314390e-03  2.650138e-03  3.898209e-03  0.0070723737
## C16.1_T4           4.396935e-02 -3.943263e-02  8.631091e-02  0.0534711752
## C16.2_T4          -2.387415e-03  3.114819e-03  4.285391e-03  0.0059751157
## C16.2.OH_T4        4.438919e-02 -3.905340e-02  8.588765e-02  0.0545069912
## C18.1_T4          -1.352201e-03  2.221288e-03  3.321842e-03  0.0070751591
## C18.1.OH_T4       -2.193846e-03  3.398243e-03  4.052551e-03  0.0064228014
## C18.2_T4          -2.517465e-03  3.341636e-03  4.067541e-03  0.0060725084
## lysoPC.a.C16.0_T4 -2.298288e-02  2.747877e-02  1.300676e-02  0.0388599309
## lysoPC.a.C16.1_T4 -4.340808e-02 -2.445897e-02 -1.615224e-02  0.0029700374
## lysoPC.a.C17.0_T4  1.107806e-02  7.178495e-03 -1.255418e-02  0.0306054591
## lysoPC.a.C18.0_T4 -2.066928e-02  6.628055e-02  1.262698e-02  0.0862258503
## lysoPC.a.C18.1_T4 -9.118336e-03 -1.931437e-02 -1.799613e-02  0.0639331877
## lysoPC.a.C18.2_T4 -6.322112e-02 -3.850216e-02 -2.575335e-02  0.0331121355
## lysoPC.a.C20.3_T4 -8.878691e-03 -1.117190e-02 -1.429204e-02  0.0090249753
## lysoPC.a.C20.4_T4 -1.077844e-03  7.958515e-03  3.112701e-02  0.0250508783
## lysoPC.a.C24.0_T4 -4.941505e-03  6.570832e-03  6.085754e-03  0.0017864062
## lysoPC.a.C26.0_T4  5.487163e-02  6.621011e-02  1.666054e-03 -0.0510898266
## lysoPC.a.C26.1_T4 -2.623102e-03  5.746402e-03  1.040445e-02 -0.0032015872
## lysoPC.a.C28.0_T4  1.265323e-02  8.067463e-02  7.708868e-02 -0.0277202180
## lysoPC.a.C28.1_T4  9.332290e-04  3.768660e-03  4.229505e-03  0.0031439114
## PC.aa.C24.0_T4     2.829896e-02 -1.770496e-02  9.330993e-03 -0.1541844678
## PC.aa.C28.1_T4     1.489835e-02  9.905481e-05  5.181694e-03 -0.0114773266
## PC.aa.C30.0_T4     7.692463e-03 -1.962786e-02  1.229011e-02 -0.0126414720
## PC.aa.C32.0_T4     5.106322e-02 -4.529076e-02 -5.975948e-03 -0.0411297092
## PC.aa.C32.1_T4    -5.754990e-03 -1.077884e-01  6.405356e-02 -0.1013910240
## PC.aa.C32.3_T4     6.104595e-04  2.479951e-03  3.234311e-03  0.0058393831
## PC.aa.C34.1_T4     6.925470e-02 -3.763927e-02  5.412103e-02 -0.0387837161
## PC.aa.C34.2_T4     1.570780e-02 -2.434680e-02  1.623389e-02 -0.0401134927
## PC.aa.C34.3_T4    -3.523875e-02 -4.616252e-02 -5.123830e-03 -0.0157298624
## PC.aa.C34.4_T4     1.918708e-04 -3.531950e-03  7.636309e-03  0.0041356972
## PC.aa.C36.0_T4     1.559607e-02 -7.209370e-04  6.399088e-03  0.0092976725
## PC.aa.C36.1_T4     5.266121e-02 -3.594932e-03  3.179380e-02  0.0092643951
## PC.aa.C36.2_T4     1.514323e-02  1.024480e-02  2.453395e-02  0.0167975105
## PC.aa.C36.3_T4     8.471486e-03 -5.976314e-03 -6.396900e-02 -0.0096184553
## PC.aa.C36.4_T4     4.184770e-02  2.394290e-02  4.147932e-02 -0.0307961794
## PC.aa.C36.5_T4     1.533387e-02 -7.071836e-02  5.169092e-02 -0.0435907994
## PC.aa.C38.0_T4     4.304036e-02 -1.329687e-02  1.726561e-02 -0.0017508235
## PC.aa.C38.1_T4     2.313971e-02 -8.867637e-03  1.456353e-02 -0.0096924108
## PC.aa.C38.3_T4     1.712325e-02 -3.005174e-02 -6.154575e-02 -0.0115189725
## PC.aa.C38.4_T4     4.356033e-02  3.146010e-02  5.634811e-02 -0.0205778399
## PC.aa.C38.5_T4     2.320561e-03 -1.771780e-02  3.051391e-02 -0.0403356832
## PC.aa.C38.6_T4     4.649171e-02 -5.938191e-02  7.532861e-02 -0.0555584693
## PC.aa.C40.1_T4     1.320841e-01  2.868216e-02  2.398573e-02 -0.0736924448
## PC.aa.C40.2_T4     3.184667e-03  1.476429e-03 -2.047353e-03  0.0081055947
## PC.aa.C40.3_T4     4.271214e-03  3.729163e-03 -7.708800e-04  0.0084328988
## PC.aa.C40.4_T4    -2.204919e-02 -3.331962e-03  2.417183e-02 -0.0077377122
## PC.aa.C40.5_T4    -2.299849e-02 -5.634706e-03  1.691762e-02 -0.0309034301
## PC.aa.C40.6_T4     2.000840e-02 -4.842347e-02  5.622556e-02 -0.0155328996
## PC.aa.C42.0_T4     5.924360e-03 -4.779479e-03  2.434736e-03 -0.0002313004
## PC.aa.C42.1_T4     3.748863e-03  2.993620e-04  8.391006e-04  0.0039439321
## PC.aa.C42.2_T4    -4.937252e-05  1.276476e-03  5.450458e-03  0.0059963805
## PC.aa.C42.4_T4    -3.971156e-04  3.990345e-03  2.583477e-03  0.0044442398
## PC.aa.C42.5_T4    -1.756861e-05 -2.793080e-04  6.212867e-03  0.0038005231
## PC.aa.C42.6_T4     5.950238e-02 -3.872319e-02 -8.181380e-02 -0.0360062520
## PC.ae.C30.0_T4     4.724041e-02  5.834844e-02 -6.315106e-02 -0.0886766510
## PC.ae.C32.1_T4     1.795737e-02 -7.385878e-04  5.503691e-03 -0.0103424751
## PC.ae.C32.2_T4     3.144257e-03  3.335115e-03  6.640222e-03  0.0015220793
## PC.ae.C34.0_T4     6.313407e-03 -9.887752e-04  2.784002e-03  0.0031634489
## PC.ae.C34.1_T4     5.775790e-02 -1.599711e-02 -2.674339e-02 -0.0268347044
## PC.ae.C34.2_T4     4.787880e-02 -1.415214e-02 -4.222458e-03 -0.0203485417
## PC.ae.C34.3_T4     4.407231e-02  1.489554e-02  4.536599e-03 -0.0177330733
## PC.ae.C36.0_T4     6.377251e-03  4.172809e-03  9.522905e-03  0.0103735629
## PC.ae.C36.1_T4     1.934705e-02 -1.516440e-03 -1.525456e-02 -0.0023666017
## PC.ae.C36.2_T4     4.130574e-02 -6.043871e-03 -3.525121e-02 -0.0160326780
## PC.ae.C36.3_T4     2.513686e-02 -6.644258e-04 -1.007524e-02 -0.0153048808
## PC.ae.C36.4_T4     3.300478e-02  2.101007e-02  9.954719e-03 -0.0469947202
## PC.ae.C36.5_T4     6.506393e-02  3.108003e-02  2.612297e-02  0.0175121224
## PC.ae.C38.0_T4    -1.061625e-03 -1.301439e-02  2.001529e-02 -0.0065272378
## PC.ae.C38.2_T4     1.233567e-02 -7.145998e-03 -7.546513e-03  0.0056078674
## PC.ae.C38.3_T4     1.815383e-02  2.897031e-03 -2.831737e-02  0.0085014299
## PC.ae.C38.4_T4     5.452170e-02  1.923919e-02 -1.240333e-02 -0.0157969078
## PC.ae.C38.5_T4     4.363109e-02  2.246513e-02 -7.862893e-03 -0.0092615749
## PC.ae.C38.6_T4     3.664669e-02  1.236489e-02  5.112273e-03  0.0058186566
## PC.ae.C40.1_T4     2.265279e-03  2.541712e-03  1.226559e-02  0.0005718180
## PC.ae.C40.2_T4     2.699756e-02 -6.653917e-03 -1.961616e-02  0.0081096515
## PC.ae.C40.3_T4     1.789768e-02 -5.054063e-03 -1.147818e-02  0.0063058664
## PC.ae.C40.4_T4     2.043756e-02 -5.243066e-03 -2.878021e-03 -0.0062419091
## PC.ae.C40.5_T4    -1.324376e-04 -1.728638e-03 -5.152203e-03 -0.0190118366
## PC.ae.C40.6_T4     1.304306e-02 -2.672310e-03  6.082923e-03 -0.0140233994
## PC.ae.C42.1_T4     2.105964e-03  2.762286e-03 -1.079573e-04  0.0091414879
## PC.ae.C42.2_T4     6.885076e-03 -3.325036e-03 -3.417400e-03  0.0045052069
## PC.ae.C42.3_T4    -1.295261e-04 -1.284316e-03  2.373171e-03 -0.0040239643
## PC.ae.C42.4_T4     2.582164e-03 -2.917155e-03  1.272745e-03 -0.0087685925
## PC.ae.C42.5_T4     1.353818e-02 -1.027434e-02 -1.141230e-02 -0.0218258121
## PC.ae.C44.3_T4    -1.483547e-03  2.419682e-03  3.434879e-03  0.0060804853
## PC.ae.C44.4_T4     1.617966e-03 -8.990964e-04  1.523021e-03  0.0009901088
## PC.ae.C44.5_T4     8.375825e-03 -1.433421e-02 -1.446361e-02 -0.0294125468
## PC.ae.C44.6_T4     5.938996e-03 -9.680259e-03 -3.407703e-03 -0.0150230962
## SM..OH..C14.1_T4   3.311171e-02  2.586297e-02 -2.646339e-02 -0.0094345947
## SM..OH..C16.1_T4   2.192889e-02  1.319694e-02 -1.103629e-02  0.0087253857
## SM..OH..C22.1_T4   1.526934e-02  2.418490e-02  2.134656e-02  0.0124647716
## SM..OH..C22.2_T4   4.136788e-02  1.048579e-02 -4.565778e-02  0.0057622026
## SM..OH..C24.1_T4   2.622983e-03  4.574886e-03  1.251171e-03  0.0131208373
## SM.C16.0_T4        4.388225e-02  4.336737e-02 -5.336043e-03  0.0004064156
## SM.C16.1_T4        2.652389e-02  4.277011e-02  2.215265e-02 -0.0206510972
## SM.C18.0_T4        4.526235e-02  1.916326e-02 -8.205843e-02  0.0197404688
## SM.C18.1_T4        2.223738e-02  7.535450e-04 -6.494792e-02  0.0041886599
## SM.C20.2_T4        1.126141e-04  1.160264e-03  1.297424e-03  0.0094171241
## SM.C24.0_T4        8.973638e-03  5.544327e-02  6.649922e-02 -0.0246293353
## SM.C24.1_T4        2.990172e-02 -3.124843e-02 -9.690472e-02 -0.0053719105
## MEDDM_T5          -1.951234e-02 -8.207121e-03 -4.153529e-03 -0.0156086818
## MEDCOL_T5         -1.951234e-02 -8.207121e-03 -4.153529e-03 -0.0156086818
## MEDINF_T5         -1.868307e-02 -6.961066e-03  2.287041e-03 -0.0028686707
## MEDHTA_T5         -1.356211e-02 -6.800016e-03 -2.350989e-03 -0.0144375490
## GLU_T5             3.946821e-02 -4.802696e-03 -1.042177e-02 -0.0381152571
## INS_T5            -5.403671e-02  3.782656e-02 -4.809892e-02 -0.0295899402
## HOMA_T5           -1.671496e-02  1.677707e-02 -2.153630e-02 -0.0037237445
## HBA1C_T5          -6.076932e-03  2.139274e-02  1.784360e-02 -0.0088492886
## HBA1C.mmol.mol_T5 -7.792253e-03  4.662813e-02  4.484782e-02 -0.0311411373
## PESO_T5            4.736569e-03 -3.052931e-02  3.594963e-02 -0.0523119517
## bmi_T5             9.329127e-03 -1.719303e-02  6.750128e-02 -0.0154212332
## CC_T5             -1.558960e-03 -5.760133e-04  4.474557e-03  0.0046524932
## CINT_T5            6.083968e-02 -3.264689e-02  5.766488e-02 -0.0355488467
## CAD_T5             2.429637e-02  2.813279e-02  5.188585e-03 -0.0295253893
## TAD_T5            -3.243004e-02 -7.434635e-02 -2.956070e-02  0.0091575818
## TAS_T5             3.774555e-02  1.650555e-02 -2.905747e-02  0.0730203455
## TG_T5             -3.738079e-03  6.925571e-03 -5.959140e-02  0.0045283635
## COL_T5             5.282862e-02 -4.616577e-02 -1.087088e-02  0.0628982154
## LDL_T5             5.198142e-02 -4.863785e-02 -1.863269e-02  0.0877373669
## HDL_T5             8.131053e-02 -3.130796e-02  3.233920e-02  0.0096667718
## VLDL_T5            3.503331e-03 -1.758739e-02  5.584311e-02 -0.0491355395
## PCR_T5             3.114229e-02 -4.433540e-02  2.100436e-02  0.0138540737
## LEP_T5            -5.249479e-02  8.124460e-02 -1.041466e-02 -0.0433616936
## ADIPO_T5          -2.950497e-02 -1.190458e-02  1.676287e-02  0.0232770295
## GOT_T5             7.276997e-02  9.452310e-02  2.475117e-02  0.0183285589
## GPT_T5            -2.553337e-02  1.940762e-02 -3.952059e-02 -0.0708541822
## GGT_T5             2.807282e-02  1.912275e-02 -1.366991e-02  0.0761187766
## URICO_T5           2.219095e-02 -4.160329e-02 -3.250279e-03 -0.0205723089
## CREAT_T5          -2.215261e-03 -8.419458e-04  1.916961e-03  0.0023261313
## UREA_T5           -2.596994e-03  2.494744e-02  6.771487e-03  0.0371478339
## HIERRO_T5         -1.007001e-01  4.658165e-03 -1.253491e-02 -0.0880194608
## TRANSF_T5          6.747244e-02 -2.610538e-02 -5.584282e-02  0.0045333196
## FERR_T5           -1.038696e-01 -1.296639e-01 -2.118846e-02 -0.0630443827
## Ile_T5             1.610163e-02  2.595617e-03  4.898517e-02 -0.0425873876
## Leu_T5            -2.530749e-03  3.277011e-02  4.300272e-02  0.0046225504
## Val_T5            -5.339700e-03  7.318794e-02  6.862467e-02  0.0313137996
## Ala_T5             4.028891e-02  3.040108e-02  2.376156e-02 -0.0445480064
## Pro_T5             3.763420e-02 -7.544109e-02 -6.231861e-02 -0.0405490935
## Gly_T5            -6.485603e-02 -3.008629e-02 -3.401015e-02 -0.0162873306
## Ser_T5             2.903794e-02  4.666751e-02  6.165543e-02  0.0396398125
## Trp_T5             1.867824e-02 -3.447721e-02  2.561649e-02  0.0002255213
## Phe_T5             2.220562e-02  6.861859e-02  4.700623e-02  0.0343014228
## Met_T5             8.715455e-03 -1.809027e-02 -2.843251e-02 -0.0436760298
## Orn_T5             3.981184e-02  6.320280e-02  6.258431e-03  0.0988599883
## Arg_T5             4.581244e-03 -3.843742e-02  2.654730e-02  0.0293731169
## His_T5            -1.600109e-02 -1.537728e-02  5.293467e-03 -0.0583977571
## Asn_T5             3.358144e-02  9.943625e-02  4.756919e-02  0.0009314317
## Asp_T5             3.275578e-02 -3.117968e-02  1.448840e-02 -0.0237653182
## Glu_T5             3.359622e-02 -8.992682e-03 -1.026237e-02 -0.0029724020
## Gln_T5             1.130185e-02  6.175865e-02  4.834133e-02  0.0506231254
## Cit_T5             2.666782e-02  6.193977e-02  7.907580e-02  0.0301333641
## Tyr_T5             5.708586e-04  7.175630e-02 -4.856447e-03  0.0198390957
## Thr_T5             8.078216e-02 -3.389766e-03  1.403428e-02  0.0276615041
## Lys_T5            -4.438248e-02 -9.988350e-03  2.286946e-02 -0.0049319073
## Creatinine_T5     -1.040740e-02 -9.746686e-02  3.053278e-02 -0.0659348769
## Kynurenine_T5      5.357051e-02 -4.245351e-02  7.562798e-03 -0.0003737743
## Putrescine_T5     -7.930807e-02  8.163882e-02  2.557913e-02 -0.1098140986
## Sarcosine_T5       7.133715e-02 -4.178248e-02  6.437529e-02 -0.0351813985
## Serotonin_T5      -7.494266e-03  6.394592e-02  5.898545e-02  0.0252973618
## Taurine_T5         2.718955e-02  1.339329e-01  3.510970e-03  0.0421145742
## SDMA_T5            4.409964e-03  4.272004e-03  7.454199e-03  0.0050330628
## C0_T5              5.251697e-02 -6.416533e-02  5.117764e-02  0.0267527657
## C2_T5             -4.653689e-02 -5.445559e-02  2.556095e-02 -0.0473709465
## C3.OH_T5          -4.447206e-03  3.874340e-03  4.671745e-03  0.0087084823
## C6..C4.1.DC._T5    6.642830e-02  2.947613e-02  2.203041e-02 -0.0110694876
## C5.DC..C6.OH._T5  -4.870542e-03  3.527643e-02  3.211865e-02  0.0170105021
## C7.DC_T5           1.485055e-03 -9.261915e-03  6.553088e-02  0.0173169250
## C8_T5             -1.625243e-03 -6.736885e-03  7.070674e-03  0.0133978855
## C10_T5             5.154824e-03 -1.434338e-02  8.091104e-03  0.0154467679
## C10.1_T5          -7.731294e-03 -1.971478e-02 -3.160473e-02  0.0298482628
## C10.2_T5          -4.159456e-04  2.413277e-03  4.565591e-03  0.0086415822
## C14.1_T5          -1.612350e-03  6.121135e-04  3.664097e-03  0.0076326494
## C14.2_T5          -1.430954e-03  3.073952e-03  4.036919e-03  0.0072088125
## C16.1_T5          -1.224667e-03  2.779140e-03  3.986755e-03  0.0068393469
## C16.2_T5          -8.426395e-04  3.291389e-03  3.750417e-03  0.0068032104
## C16.2.OH_T5        4.742613e-02  8.299535e-03  5.488433e-02  0.0463133290
## C18.1_T5          -7.139879e-05  2.414605e-03  4.228214e-03  0.0074772786
## C18.1.OH_T5       -1.226563e-03  3.346488e-03  3.534835e-03  0.0067988236
## C18.2_T5          -1.012641e-03  2.348409e-03  3.785005e-03  0.0071144103
## lysoPC.a.C16.0_T5 -1.560102e-02 -4.643606e-02 -6.266336e-03 -0.0360023737
## lysoPC.a.C16.1_T5 -5.871953e-02  2.590056e-04  1.449541e-03 -0.0252997532
## lysoPC.a.C17.0_T5 -1.041207e-02  2.251778e-03 -1.222677e-02 -0.0058640599
## lysoPC.a.C18.0_T5 -2.928823e-02 -2.436167e-02 -5.352653e-02 -0.0321562139
## lysoPC.a.C18.1_T5  2.888867e-02 -5.031650e-02  7.048866e-03 -0.0434527612
## lysoPC.a.C18.2_T5  2.821315e-02 -6.192426e-02 -1.228401e-02 -0.0221897567
## lysoPC.a.C20.3_T5 -7.303201e-03  3.755614e-02 -9.194248e-04 -0.0014640805
## lysoPC.a.C20.4_T5  2.739976e-02  6.335188e-03  2.883390e-03 -0.0477624224
## lysoPC.a.C24.0_T5 -6.350340e-03  9.959026e-04  3.769123e-03  0.0069317650
## lysoPC.a.C26.0_T5 -1.070209e-02  3.094969e-03  5.139474e-03  0.0027131364
## lysoPC.a.C26.1_T5 -7.655332e-03  5.292386e-03  3.990866e-03  0.0011751471
## lysoPC.a.C28.0_T5  1.145362e-02 -8.275785e-02 -2.546492e-02  0.0009225350
## lysoPC.a.C28.1_T5 -5.518785e-03  3.543462e-03  3.277646e-03  0.0032305922
## PC.aa.C24.0_T5    -2.215582e-02  3.452784e-02 -4.064786e-02  0.0527169404
## PC.aa.C28.1_T5     1.003732e-02  1.429493e-02  1.488456e-02  0.0208947428
## PC.aa.C30.0_T5    -1.656189e-03  1.624257e-02  1.016356e-02  0.0019092628
## PC.aa.C32.0_T5    -4.258002e-03 -3.537116e-03 -9.659442e-03  0.0247571241
## PC.aa.C32.1_T5    -9.415764e-02  2.821417e-02 -2.192053e-02 -0.0221940155
## PC.aa.C32.3_T5    -1.334080e-03  3.036087e-03  3.279295e-03  0.0076317350
## PC.aa.C34.1_T5    -4.035809e-03  8.579751e-03  1.740743e-02  0.0024905468
## PC.aa.C34.2_T5    -2.205376e-02 -6.876762e-03 -1.434340e-02  0.0244750494
## PC.aa.C34.3_T5    -7.700126e-02  2.706427e-02 -1.129760e-02  0.0174501584
## PC.aa.C34.4_T5     6.926877e-04  6.780362e-03  4.224574e-03  0.0067149556
## PC.aa.C36.0_T5    -3.428815e-03  8.597170e-04  8.050801e-03  0.0125797879
## PC.aa.C36.1_T5     1.597105e-02  5.379667e-02 -2.280386e-02  0.0543039854
## PC.aa.C36.2_T5    -2.942839e-02  1.516450e-02 -4.994867e-02  0.0347464075
## PC.aa.C36.3_T5    -3.290151e-02  4.679298e-02 -1.612874e-02  0.0178454832
## PC.aa.C36.4_T5     1.021270e-03  5.683709e-02 -8.535486e-03 -0.0264402049
## PC.aa.C36.5_T5     5.649046e-02  5.738581e-02  7.342387e-02 -0.0317865198
## PC.aa.C38.0_T5     3.108422e-02 -9.270502e-03  1.973415e-02  0.0077358761
## PC.aa.C38.1_T5    -1.092815e-02  7.194315e-04 -5.938916e-03  0.0020006156
## PC.aa.C38.3_T5    -7.324561e-03  5.448871e-02 -2.548073e-02  0.0263232748
## PC.aa.C38.4_T5    -5.005340e-02  5.700526e-02 -5.202469e-02 -0.0216735175
## PC.aa.C38.5_T5    -5.522005e-02  3.576027e-02  3.382943e-04 -0.0142595971
## PC.aa.C38.6_T5     1.446986e-02  3.921851e-03  6.062599e-02  0.0027046772
## PC.aa.C40.1_T5     5.022146e-02 -1.044588e-01 -4.172798e-02  0.0727427118
## PC.aa.C40.2_T5    -5.298059e-03  5.553925e-04  1.999775e-03  0.0055852235
## PC.aa.C40.3_T5    -1.333607e-02  1.841798e-03 -2.682183e-04  0.0039566332
## PC.aa.C40.4_T5    -4.380266e-02  1.132430e-05 -1.715984e-02 -0.0049797072
## PC.aa.C40.5_T5    -7.594313e-02  2.046833e-02 -2.595680e-02 -0.0132371786
## PC.aa.C40.6_T5    -2.781192e-02 -1.861366e-03  6.286795e-03 -0.0299499986
## PC.aa.C42.0_T5     5.642994e-03 -1.011990e-03  7.420265e-04  0.0029467229
## PC.aa.C42.1_T5     1.786022e-03 -1.032878e-03  2.663847e-03  0.0039339991
## PC.aa.C42.2_T5    -2.540146e-03  1.235731e-03  3.699792e-03  0.0060355801
## PC.aa.C42.4_T5    -5.126152e-03  2.466337e-03  1.220442e-03  0.0051508865
## PC.aa.C42.5_T5    -1.663036e-03  4.733873e-03  3.235359e-03  0.0064022044
## PC.aa.C42.6_T5    -5.186381e-02  9.733158e-02 -7.545197e-03 -0.0686448300
## PC.ae.C30.0_T5     9.443831e-03 -3.121534e-02  7.361250e-03 -0.0075923532
## PC.ae.C32.1_T5     1.670762e-02 -4.703480e-03  5.786321e-03  0.0155358846
## PC.ae.C32.2_T5     5.093396e-04  2.587079e-03  3.251630e-03  0.0103826401
## PC.ae.C34.0_T5     4.113138e-04  5.652505e-03  2.891093e-03  0.0123297328
## PC.ae.C34.1_T5     8.869211e-03 -5.543438e-03 -1.807472e-04  0.0209097783
## PC.ae.C34.2_T5     2.309301e-02 -1.887689e-02 -1.138846e-02  0.0311947413
## PC.ae.C34.3_T5     3.349193e-02 -2.645513e-02 -3.047242e-02  0.0256711070
## PC.ae.C36.0_T5     1.886787e-03 -1.715094e-03  7.173019e-03  0.0075120437
## PC.ae.C36.1_T5    -1.553113e-02  1.773331e-02 -6.512865e-03  0.0103540672
## PC.ae.C36.2_T5    -3.695870e-02  3.096609e-02 -2.759611e-02  0.0349470130
## PC.ae.C36.3_T5     4.662992e-03 -6.567343e-03 -1.864416e-02  0.0058276934
## PC.ae.C36.4_T5     2.606341e-02  3.498618e-02  2.991461e-03 -0.0014454987
## PC.ae.C36.5_T5     3.988716e-02  4.979851e-02  1.378634e-03  0.0179328991
## PC.ae.C38.0_T5     3.513271e-03  6.281925e-03  1.553243e-02  0.0093009515
## PC.ae.C38.2_T5    -2.936001e-02 -1.571018e-02 -1.427085e-02  0.0042986752
## PC.ae.C38.3_T5     6.513330e-03  1.076728e-02 -1.728209e-02  0.0108998884
## PC.ae.C38.4_T5     6.669782e-03  1.145001e-02 -2.726235e-02  0.0005438090
## PC.ae.C38.5_T5     5.887094e-02  2.248913e-02  4.970097e-03  0.0027936943
## PC.ae.C38.6_T5     1.877782e-02  3.331856e-02  1.653327e-02  0.0180900226
## PC.ae.C40.1_T5    -2.766885e-03  4.098203e-03  4.624606e-03  0.0039213734
## PC.ae.C40.2_T5     3.826788e-03  1.330901e-02  4.301617e-03  0.0125709721
## PC.ae.C40.3_T5     1.417178e-02  3.531728e-03 -9.681379e-03  0.0099391470
## PC.ae.C40.4_T5     1.452210e-02 -6.815480e-03 -8.323399e-03  0.0034308992
## PC.ae.C40.5_T5     1.889716e-02 -3.560045e-03 -1.467776e-02 -0.0076047843
## PC.ae.C40.6_T5     1.274414e-02  1.663091e-02  6.724663e-03 -0.0020651831
## PC.ae.C42.1_T5    -6.852732e-03  3.567714e-03  1.292205e-03  0.0034874138
## PC.ae.C42.2_T5    -3.738299e-03 -1.445115e-03  2.383150e-03  0.0043191104
## PC.ae.C42.3_T5    -5.470794e-04 -4.983544e-03  2.220554e-03  0.0036125439
## PC.ae.C42.4_T5     2.935018e-03 -2.961872e-03 -1.055659e-03  0.0033645499
## PC.ae.C42.5_T5     3.116598e-02 -2.427286e-02 -1.501583e-02 -0.0082605975
## PC.ae.C44.3_T5    -3.601655e-03  2.814104e-03  2.964487e-03  0.0062040463
## PC.ae.C44.4_T5     2.779208e-04 -2.349325e-03  2.738519e-04  0.0054390647
## PC.ae.C44.5_T5     2.178200e-02 -2.718235e-02 -1.080540e-02 -0.0105922839
## PC.ae.C44.6_T5     2.040884e-02 -1.754755e-02 -9.514237e-03  0.0017289749
## SM..OH..C14.1_T5  -1.737289e-02  1.237569e-03 -3.730687e-03  0.0333877246
## SM..OH..C16.1_T5  -5.378404e-04  1.426684e-02  3.062563e-03  0.0118854174
## SM..OH..C22.1_T5  -8.186528e-03 -1.765717e-02  9.953084e-03  0.0061099224
## SM..OH..C22.2_T5  -1.070244e-03 -2.494113e-02  7.257452e-03 -0.0060721008
## SM..OH..C24.1_T5   2.149863e-03  2.185020e-03  7.390468e-03  0.0062197639
## SM.C16.0_T5        1.116043e-02 -2.498311e-02  2.465440e-02  0.0090531706
## SM.C16.1_T5        1.421905e-02 -6.718143e-02  3.883380e-02  0.0327183130
## SM.C18.0_T5       -1.158250e-02  2.560164e-02  1.429141e-02  0.0055773141
## SM.C18.1_T5        1.060906e-02 -5.203994e-02  1.498737e-02  0.0016753254
## SM.C20.2_T5       -9.491492e-04  3.264879e-03  5.165943e-03  0.0053456626
## SM.C24.0_T5        8.722345e-03 -2.038496e-02  1.822526e-02 -0.0203866694
## SM.C24.1_T5        5.817849e-03 -4.096767e-03  1.698872e-02 -0.0424047647
##                            PC33          PC34          PC35          PC36
## GLU_T0             6.177124e-02  1.848829e-02 -1.999718e-02  3.080806e-02
## INS_T0             4.723905e-02 -4.426324e-02 -6.465216e-02 -1.210623e-02
## HOMA_T0            5.368581e-02 -9.354879e-03 -5.642162e-02  6.099241e-03
## HBA1C_T0           1.231277e-02  1.544559e-02  3.740204e-03 -2.095100e-02
## HBA1C.mmol.mol_T0  4.656617e-02  5.305374e-02  1.466323e-02 -6.875341e-02
## PESO_T0            6.084033e-02 -4.924924e-02  1.798927e-02 -2.325212e-02
## bmi_T0             5.541750e-02 -3.298134e-02  6.981953e-02 -8.318558e-03
## CC_T0              1.725854e-03  2.058850e-03 -7.255085e-03 -1.058908e-02
## CINT_T0           -2.198962e-02 -3.024485e-02  1.294208e-02  3.282199e-03
## CAD_T0            -1.168879e-02 -7.669047e-02  5.918786e-02  8.714827e-02
## TAD_T0             4.282167e-02 -2.549713e-02  2.923758e-02 -2.841685e-02
## TAS_T0             2.108556e-03 -7.418195e-03  4.115130e-02 -2.897735e-02
## TG_T0              2.588383e-02  6.162383e-03  2.001644e-02 -5.812408e-02
## COL_T0             1.983791e-02 -5.442365e-02 -4.951490e-02  3.563796e-02
## LDL_T0             2.722663e-02 -5.329484e-02 -8.303394e-02  7.697031e-02
## HDL_T0             2.255403e-02 -2.850080e-02  1.509587e-02 -7.474411e-03
## VLDL_T0            2.654905e-02  5.696446e-03  1.990912e-02 -5.818764e-02
## PCR_T0            -4.722453e-02 -5.229116e-02 -2.793291e-02 -3.187893e-03
## LEP_T0            -1.177368e-03 -3.497020e-02  1.940814e-02 -8.283001e-02
## ADIPO_T0           1.240905e-01 -4.092625e-02 -4.577634e-02 -3.212452e-03
## GOT_T0             8.870581e-02 -1.792707e-02 -1.274652e-02  1.034922e-01
## GPT_T0             1.042104e-01  4.855244e-02  5.323874e-02  3.385149e-02
## GGT_T0             9.710785e-03  2.524834e-02 -1.156062e-01 -8.576441e-03
## URICO_T0          -3.971577e-02 -5.652338e-02 -7.131310e-02  5.686408e-03
## CREAT_T0           4.597339e-03 -7.229208e-03  1.878814e-03 -1.232149e-03
## UREA_T0            4.197489e-02 -1.270442e-01  2.747996e-02 -5.667680e-02
## HIERRO_T0         -1.049618e-01  4.280814e-02 -6.547743e-02 -7.632146e-02
## TRANSF_T0         -4.209756e-02  5.024745e-02  7.437484e-03  1.302239e-02
## FERR_T0            4.931887e-02 -2.447155e-02 -9.001433e-02  4.279263e-02
## Ile_T0            -1.557843e-02 -8.290918e-03  3.230823e-02  4.679338e-02
## Leu_T0            -9.252646e-02  4.713734e-02 -1.216784e-02  5.002403e-02
## Val_T0            -2.640394e-02  6.219378e-02  2.376394e-02  7.642563e-03
## Ala_T0            -1.264750e-02 -9.969321e-02 -6.444632e-02  1.343997e-04
## Pro_T0             7.301387e-02  1.765965e-02  1.117267e-01 -1.517798e-02
## Gly_T0             2.103665e-03  3.215125e-02 -4.961049e-02 -3.075851e-02
## Ser_T0             3.064333e-02  2.632949e-02 -4.107496e-02 -1.673735e-02
## Trp_T0            -2.898190e-02  2.750632e-03  7.850388e-02  3.294681e-02
## Phe_T0            -4.497471e-03  1.240967e-02  1.525337e-02 -6.324090e-03
## Met_T0            -2.692811e-03 -1.769305e-02 -3.047385e-02  2.557179e-02
## Orn_T0             4.755048e-02  3.669016e-03  6.826804e-02  2.720700e-02
## Arg_T0             5.463524e-02 -1.226894e-02 -1.748792e-02 -9.163377e-03
## His_T0            -9.819820e-03 -6.826933e-02  2.065264e-02  2.375738e-02
## Asn_T0            -8.788148e-04 -5.039831e-02 -5.648985e-02  3.568835e-02
## Asp_T0            -2.433261e-03 -1.575308e-03 -3.965222e-02  1.963499e-02
## Glu_T0             1.591033e-02 -2.536409e-03 -2.379968e-02 -2.471632e-02
## Gln_T0             2.286603e-02  6.714870e-02 -2.296488e-02 -7.318750e-02
## Cit_T0             2.206265e-02 -1.295856e-01 -2.237554e-02 -3.051934e-02
## Tyr_T0             3.485192e-02 -6.722577e-02  1.010940e-01 -6.520133e-02
## Thr_T0             4.462822e-02 -8.812588e-02  6.550170e-02 -8.145268e-02
## Lys_T0             9.462162e-02  6.920806e-02  5.611503e-02 -8.518370e-02
## Creatinine_T0      7.046319e-02 -2.807934e-02  7.110820e-02  7.724121e-03
## Kynurenine_T0      6.158230e-02  2.157610e-02  4.180384e-02 -2.937582e-02
## Putrescine_T0      1.262800e-01 -1.397757e-02 -1.231080e-01 -7.441364e-02
## Sarcosine_T0       3.116288e-02  5.239484e-02  4.410193e-02 -8.132402e-02
## Serotonin_T0      -7.788962e-02  1.129112e-01 -1.091230e-01 -8.057317e-02
## Taurine_T0        -4.536899e-02  3.720298e-02 -2.123972e-02 -6.664680e-03
## SDMA_T0           -1.677638e-04  1.792789e-03  1.448173e-02 -1.992351e-02
## C0_T0              4.038535e-02 -5.792470e-02 -1.005616e-02 -3.356049e-02
## C2_T0              1.171165e-01 -7.955371e-02  2.799032e-02 -4.013525e-02
## C3.OH_T0           5.656374e-03 -7.083057e-03 -2.633580e-03  4.886923e-03
## C6..C4.1.DC._T0   -1.245313e-02 -9.331689e-02 -9.143165e-02  5.860766e-02
## C5.DC..C6.OH._T0   1.720561e-02  8.794856e-02 -3.591306e-02  1.683146e-02
## C7.DC_T0           1.385245e-01 -4.238119e-03  4.283459e-02 -3.062993e-02
## C8_T0              7.749028e-03 -1.305164e-02  2.522399e-03 -2.925430e-03
## C10_T0             1.760241e-02 -3.705407e-03 -7.673211e-03 -5.000844e-03
## C10.1_T0           1.126625e-02 -2.702988e-03 -4.262000e-03 -3.390677e-03
## C10.2_T0           5.510784e-03 -5.424947e-03 -1.351346e-03  7.842518e-04
## C14.1_T0           6.152193e-03 -3.248544e-03 -2.703965e-03 -2.704157e-03
## C14.2_T0           4.652372e-03 -4.838569e-03 -4.201681e-03 -1.354434e-03
## C16.1_T0           3.683909e-03 -4.229939e-03 -6.482238e-04 -6.800247e-04
## C16.2_T0           3.241681e-03 -3.740274e-03 -1.902303e-03  1.702781e-03
## C16.2.OH_T0        3.404412e-03 -4.405002e-03 -3.422452e-04  1.331919e-03
## C18.1_T0           3.904052e-03 -3.596709e-03 -5.560590e-04 -8.375768e-04
## C18.1.OH_T0        2.579825e-03 -4.007293e-03 -2.116971e-03  2.134725e-03
## C18.2_T0           2.964809e-03 -4.032967e-03 -1.883821e-03  8.011779e-04
## lysoPC.a.C16.0_T0 -1.673356e-02 -1.616807e-02  4.123509e-02 -1.809499e-02
## lysoPC.a.C16.1_T0 -3.617442e-03  9.514075e-03  3.478218e-02  2.809260e-04
## lysoPC.a.C17.0_T0 -4.377135e-03  1.288832e-02  2.312110e-02  1.591319e-02
## lysoPC.a.C18.0_T0 -1.916548e-02 -3.043385e-02  1.686891e-02 -2.883884e-03
## lysoPC.a.C18.1_T0 -9.658178e-03 -2.545349e-02  1.731783e-02  3.710357e-02
## lysoPC.a.C18.2_T0  5.912615e-02  2.355479e-02 -2.207912e-02 -1.318941e-02
## lysoPC.a.C20.3_T0 -2.813953e-02 -1.165988e-03  5.696584e-03  7.203587e-02
## lysoPC.a.C20.4_T0 -7.264832e-02 -3.253345e-03 -1.322614e-02  2.015768e-02
## lysoPC.a.C24.0_T0  6.749710e-03 -9.396803e-03 -9.493631e-04  1.337295e-02
## lysoPC.a.C26.0_T0  1.330837e-02  1.654462e-02 -7.825633e-02  4.822388e-02
## lysoPC.a.C26.1_T0  5.118582e-04 -8.441365e-03 -5.300272e-03  2.819321e-03
## lysoPC.a.C28.0_T0 -4.921513e-02 -3.004106e-02 -3.624107e-02 -1.374686e-02
## lysoPC.a.C28.1_T0  1.521864e-03 -3.650571e-03 -3.724861e-03  8.993916e-05
## PC.aa.C24.0_T0    -2.095431e-02 -9.599628e-02 -1.923210e-02  9.883654e-02
## PC.aa.C28.1_T0    -5.116071e-03  1.828717e-02  9.267266e-03 -2.195270e-02
## PC.aa.C30.0_T0     4.457123e-03 -1.701496e-03 -1.074099e-02  6.322717e-02
## PC.aa.C32.0_T0     8.808951e-03  5.692976e-03  3.715144e-02  1.068255e-01
## PC.aa.C32.1_T0    -4.450511e-03  1.780353e-02 -4.592519e-03  6.559336e-02
## PC.aa.C32.3_T0     3.564139e-03 -5.098695e-03 -4.558131e-04  4.198439e-03
## PC.aa.C34.1_T0     2.077180e-02 -1.007178e-02 -6.108511e-03  5.295730e-02
## PC.aa.C34.2_T0     7.038722e-02 -3.856622e-02 -1.566067e-03 -7.569088e-02
## PC.aa.C34.3_T0     8.697313e-03 -2.014281e-02  6.402077e-04  1.894291e-02
## PC.aa.C34.4_T0    -1.930296e-03 -1.700429e-02 -1.320854e-02  1.492876e-02
## PC.aa.C36.0_T0     3.110768e-03  8.797397e-03  9.989321e-03 -1.900153e-03
## PC.aa.C36.1_T0    -1.360008e-02 -9.502390e-02 -2.087361e-02  4.512986e-02
## PC.aa.C36.2_T0     4.636597e-02 -5.537991e-02 -3.645223e-02 -6.798981e-02
## PC.aa.C36.3_T0    -1.054876e-02 -5.741649e-02  2.280933e-02  6.146668e-02
## PC.aa.C36.4_T0    -3.624542e-02 -4.498101e-02  1.381459e-02 -4.061575e-03
## PC.aa.C36.5_T0    -1.271675e-02  1.479180e-02  1.060578e-01  3.277473e-02
## PC.aa.C38.0_T0    -4.036328e-03  5.467402e-03  3.433405e-02  1.537171e-02
## PC.aa.C38.1_T0     1.818370e-02 -1.019066e-02  1.528518e-02  3.786139e-02
## PC.aa.C38.3_T0    -2.466672e-02 -7.706939e-02  2.240239e-02  6.406367e-02
## PC.aa.C38.4_T0    -4.542884e-02 -6.236637e-02 -9.990160e-03  4.876427e-02
## PC.aa.C38.5_T0     1.464493e-02  2.658236e-02  6.115717e-02  1.513682e-02
## PC.aa.C38.6_T0     5.330052e-02 -2.888469e-02  7.438040e-02  4.556080e-03
## PC.aa.C40.1_T0    -2.805738e-02  3.527967e-02 -1.107484e-02  7.158935e-03
## PC.aa.C40.2_T0    -4.001677e-03 -2.961530e-03  7.373033e-04 -6.647071e-03
## PC.aa.C40.3_T0    -2.019850e-03 -8.097840e-03  3.108839e-03 -2.188646e-04
## PC.aa.C40.4_T0     6.998579e-03  8.495565e-03  1.234807e-02 -1.003835e-02
## PC.aa.C40.5_T0    -1.574397e-03 -8.574212e-03  3.332484e-02  1.052817e-03
## PC.aa.C40.6_T0     4.782177e-02 -4.163116e-02  1.221194e-01  1.178603e-02
## PC.aa.C42.0_T0    -1.648758e-03 -6.355556e-04  4.406960e-03  5.572796e-04
## PC.aa.C42.1_T0     2.425545e-03 -2.545229e-03  2.861560e-03 -1.177896e-04
## PC.aa.C42.2_T0    -4.734955e-05 -4.581570e-03  3.214666e-03 -2.741161e-03
## PC.aa.C42.4_T0     5.912361e-04 -2.661616e-03  3.198605e-03  1.344763e-03
## PC.aa.C42.5_T0     1.826560e-03 -9.324847e-04 -4.932944e-04  3.496773e-03
## PC.aa.C42.6_T0    -2.573963e-02 -1.059639e-02 -4.372586e-02  1.009424e-02
## PC.ae.C30.0_T0    -7.516526e-04  1.005163e-03  2.125731e-03  2.826654e-03
## PC.ae.C32.1_T0    -1.320083e-02  2.311314e-02  2.182880e-02  8.941901e-03
## PC.ae.C32.2_T0     1.042918e-03 -7.199079e-04  9.037812e-03  3.553664e-03
## PC.ae.C34.0_T0    -2.761215e-03  9.281932e-03  9.207850e-03  7.293056e-03
## PC.ae.C34.1_T0    -1.908872e-02  1.262645e-02  2.650650e-02  3.797661e-02
## PC.ae.C34.2_T0     1.490784e-02  5.209626e-03 -1.289851e-02  6.819930e-02
## PC.ae.C34.3_T0     4.123700e-03 -5.634095e-03 -1.703281e-02 -3.473835e-03
## PC.ae.C36.0_T0     2.545226e-03 -2.430401e-03  2.456159e-03  9.474722e-03
## PC.ae.C36.1_T0    -7.216095e-03  5.117093e-03  1.343239e-02 -8.836671e-03
## PC.ae.C36.2_T0     6.509531e-03  1.472681e-02  3.103773e-02 -7.574557e-03
## PC.ae.C36.3_T0     1.400610e-02 -6.371572e-03 -2.112645e-02  5.781125e-02
## PC.ae.C36.4_T0    -3.697684e-02  4.457777e-02 -2.995989e-02  4.339813e-02
## PC.ae.C36.5_T0    -3.111349e-02  4.818214e-02  2.964846e-02  2.129001e-02
## PC.ae.C38.0_T0    -7.113458e-03 -6.666165e-03  2.340031e-03 -5.222475e-03
## PC.ae.C38.2_T0    -1.459864e-02  4.455962e-03  1.562617e-02 -2.569139e-02
## PC.ae.C38.3_T0    -1.741326e-02 -1.834660e-03  1.262245e-03  6.922950e-03
## PC.ae.C38.4_T0    -4.667427e-02  6.083967e-02  4.024411e-03  1.370905e-02
## PC.ae.C38.5_T0    -1.360820e-02  3.912812e-02  2.353043e-02  3.917278e-02
## PC.ae.C38.6_T0    -4.087954e-04  1.976888e-02  4.321303e-02  2.024006e-02
## PC.ae.C40.1_T0    -1.264570e-03 -1.582277e-02  1.374504e-03 -3.756980e-03
## PC.ae.C40.2_T0    -1.079117e-02  1.446540e-02  1.854808e-02 -7.534586e-03
## PC.ae.C40.3_T0    -1.404889e-02 -2.618539e-03  5.051882e-03 -6.241718e-03
## PC.ae.C40.4_T0    -2.150620e-02  2.034679e-02  1.014619e-02 -4.067720e-03
## PC.ae.C40.5_T0    -1.357528e-02  1.513235e-02  1.800984e-02  2.581932e-04
## PC.ae.C40.6_T0     2.207332e-03  2.205004e-02  3.504770e-02  2.628809e-03
## PC.ae.C42.1_T0     3.259163e-03 -5.338091e-03  2.137219e-03 -8.858046e-04
## PC.ae.C42.2_T0    -1.100979e-03 -1.683039e-03  3.220573e-03 -4.365996e-03
## PC.ae.C42.3_T0     1.571863e-03 -7.250826e-03  5.804319e-03 -7.847871e-03
## PC.ae.C42.4_T0    -7.725219e-03  3.086941e-03 -4.239043e-03 -1.220054e-02
## PC.ae.C42.5_T0    -2.459670e-02  1.616318e-02  1.015091e-02 -1.546741e-03
## PC.ae.C44.3_T0     3.259718e-03 -3.865322e-03  1.203264e-03 -2.241184e-04
## PC.ae.C44.4_T0     2.256718e-03  1.299221e-03 -7.543764e-03  7.931163e-04
## PC.ae.C44.5_T0    -9.713322e-03  2.323594e-02  8.407531e-03 -2.326736e-03
## PC.ae.C44.6_T0    -7.869549e-03  9.031787e-03  1.231966e-02 -9.287955e-03
## SM..OH..C14.1_T0  -1.206387e-02  7.637409e-02  1.163991e-02  2.433765e-03
## SM..OH..C16.1_T0   6.236148e-03  1.631472e-02  1.169190e-03 -9.418055e-03
## SM..OH..C22.1_T0  -5.815749e-02 -6.102989e-03 -3.462859e-02  1.257904e-02
## SM..OH..C22.2_T0  -4.652941e-02  1.615973e-02  1.833480e-02 -2.148089e-02
## SM..OH..C24.1_T0  -1.011439e-03  3.854518e-03  1.341700e-03 -2.393987e-03
## SM.C16.0_T0        4.993957e-03 -1.017161e-02 -6.236431e-02  2.848917e-02
## SM.C16.1_T0        4.356535e-02 -6.960150e-03  5.190569e-02 -8.568410e-02
## SM.C18.0_T0        2.421285e-02  2.358433e-02 -9.479895e-02 -3.676540e-02
## SM.C18.1_T0        4.302277e-02 -2.056956e-02 -1.407185e-02 -1.290026e-01
## SM.C20.2_T0        1.007658e-03  3.436142e-04 -2.588749e-03  6.749759e-03
## SM.C24.0_T0       -2.504011e-02 -7.498023e-02 -9.438140e-02  3.108451e-02
## SM.C24.1_T0       -2.294214e-02 -4.313525e-02 -5.539664e-02  6.013529e-02
## MEDDM_T2           2.668735e-03 -2.944163e-03 -1.501050e-03  2.207501e-03
## MEDCOL_T2          2.668735e-03 -2.944163e-03 -1.501050e-03  2.207501e-03
## MEDINF_T2          1.682208e-02 -1.752683e-02 -1.905706e-02  1.547918e-02
## MEDHTA_T2         -6.891035e-03  2.260814e-02 -1.328919e-02  1.275571e-02
## GLU_T2            -4.570527e-02  1.939231e-02  6.362681e-02  1.018006e-02
## INS_T2            -4.114747e-02 -1.854683e-02  5.941759e-02 -6.121257e-02
## HOMA_T2           -3.993229e-02 -9.893382e-03  3.327398e-02 -2.315196e-02
## HBA1C_T2          -2.471319e-03  6.779299e-04  1.164125e-02  5.141815e-04
## HBA1C.mmol.mol_T2  4.000010e-03  1.279270e-02  5.006008e-02 -7.781708e-03
## PESO_T2            2.404442e-02 -1.583119e-02  3.707688e-02  2.486513e-02
## bmi_T2             1.410854e-02  2.741201e-03  9.872995e-02  4.291013e-02
## CC_T2             -9.307507e-03 -5.776549e-03 -6.081675e-03 -2.930638e-03
## CINT_T2           -9.710244e-02 -3.105932e-02 -2.471876e-02  6.089865e-03
## CAD_T2            -3.356667e-03 -2.607943e-02  1.397538e-02  6.476737e-02
## TAD_T2             6.559047e-03  1.805183e-02  6.788121e-02  7.050888e-02
## TAS_T2             7.514144e-02  2.972199e-02 -1.140894e-02 -5.231541e-03
## TG_T2              1.197355e-01 -1.500382e-03  1.021529e-01 -5.224456e-02
## COL_T2             5.996964e-02 -2.992649e-03  8.717807e-02 -1.805720e-02
## LDL_T2             2.401611e-02 -2.843633e-02  8.650587e-02  3.514583e-05
## HDL_T2             7.821812e-02  5.452385e-02  2.597321e-03 -2.426120e-02
## VLDL_T2            1.984380e-02  7.046217e-03  1.563992e-02 -2.658621e-02
## PCR_T2             2.894130e-02 -4.987453e-02  7.954493e-02 -2.653188e-02
## LEP_T2             1.935651e-02  3.951189e-02  7.296870e-03 -4.614283e-02
## ADIPO_T2           3.652449e-02 -9.358185e-03 -2.867175e-02  1.488694e-02
## GOT_T2            -2.940659e-02  7.218945e-03  1.770379e-02 -1.440264e-01
## GPT_T2            -8.044468e-02  3.173460e-02  2.396456e-02 -2.629069e-01
## GGT_T2             7.253275e-02  3.013837e-02 -1.820677e-02 -1.438159e-01
## URICO_T2          -3.211473e-02 -7.391663e-02 -5.578677e-02 -1.619452e-02
## CREAT_T2           2.159655e-03  1.985047e-03 -1.428237e-03  4.911879e-03
## UREA_T2           -1.331356e-01  3.911130e-02 -5.505046e-02  6.943138e-02
## HIERRO_T2          6.728362e-02 -5.426084e-02  3.129780e-02  1.183156e-01
## TRANSF_T2         -4.766121e-02 -1.633539e-02 -2.392136e-02 -4.135679e-02
## FERR_T2           -7.802336e-02 -2.919080e-03  1.187694e-02  2.260922e-03
## Ile_T2            -6.723977e-02  5.678461e-04 -2.419299e-02  1.993041e-02
## Leu_T2            -2.905746e-02 -3.984059e-03  6.115906e-03  2.451041e-02
## Val_T2            -3.317300e-02  1.487754e-02 -1.386384e-02  5.948030e-02
## Ala_T2            -1.749177e-02  7.588916e-02  8.209562e-02  5.865264e-02
## Pro_T2             1.182098e-02  7.541496e-02 -3.794199e-03  1.085118e-04
## Gly_T2            -1.182576e-01 -2.679758e-02 -1.033795e-01 -6.701407e-02
## Ser_T2            -4.900838e-02  4.075130e-02  3.369053e-03  1.765945e-02
## Trp_T2            -7.439418e-02 -1.313949e-03 -3.368107e-02 -4.803597e-02
## Phe_T2             1.375372e-02  1.994784e-03  3.756296e-02 -1.614427e-02
## Met_T2            -5.326031e-02  1.634469e-02  2.782972e-02 -1.848627e-02
## Orn_T2            -8.158957e-03 -1.326520e-02  4.939474e-02  3.324077e-02
## Arg_T2             8.736968e-02  1.223705e-02  5.102004e-03  8.779946e-02
## His_T2            -2.098698e-02 -3.059346e-02  6.529279e-02  7.795623e-02
## Asn_T2            -1.072629e-02 -4.720545e-02  2.775904e-02  2.054086e-02
## Asp_T2             4.322092e-02 -8.501933e-03 -3.906025e-03  5.107535e-03
## Glu_T2             3.798142e-02  7.490913e-03 -1.513502e-02 -2.848395e-02
## Gln_T2            -4.362387e-02  4.088093e-02 -6.188496e-02  7.151829e-02
## Cit_T2            -1.055374e-02 -3.721640e-02  8.982772e-02 -1.515561e-02
## Tyr_T2            -7.088334e-02 -7.024086e-02  8.068050e-02  1.909948e-02
## Thr_T2             1.986340e-03 -8.906686e-02  1.050705e-02 -9.928479e-02
## Lys_T2            -2.097926e-02 -2.735394e-02  1.100230e-01  1.350894e-02
## Creatinine_T2      6.483049e-03 -2.288386e-03  2.469796e-02  1.327157e-04
## Kynurenine_T2     -1.160758e-02 -1.388568e-03  2.169626e-02 -3.947494e-02
## Putrescine_T2     -8.836621e-02  3.284911e-02 -6.474941e-03 -1.205042e-01
## Sarcosine_T2      -2.972583e-02  5.141956e-02  1.541067e-02 -1.284317e-01
## Serotonin_T2       3.305737e-02  1.308341e-02 -6.516640e-03  3.350923e-02
## Taurine_T2        -1.036320e-01 -1.281883e-03  9.857142e-02 -9.249422e-02
## SDMA_T2            1.053032e-02  1.745527e-03  1.059940e-02 -2.096192e-02
## C0_T2             -2.321632e-02 -1.832956e-02  3.270503e-02  5.603542e-02
## C2_T2              6.188228e-02 -8.556484e-02 -7.624467e-02  7.838213e-02
## C3.OH_T2          -6.664685e-04 -2.402473e-03 -3.353376e-03  5.242346e-03
## C6..C4.1.DC._T2   -5.231586e-02  5.845508e-02 -2.896243e-02 -1.284240e-02
## C5.DC..C6.OH._T2  -3.269099e-02  3.322787e-02 -4.081070e-02 -8.453599e-02
## C7.DC_T2           8.816849e-02  1.071233e-01  3.209841e-02  7.288646e-02
## C8_T2              3.041680e-03  3.679926e-03  1.411638e-03  7.003910e-03
## C10_T2             8.945860e-03  4.788566e-03  1.045411e-02  4.848948e-03
## C10.1_T2           8.642744e-03  2.873013e-05  2.053809e-03  3.329449e-03
## C10.2_T2           6.713043e-04 -1.467397e-03  8.938108e-04  3.070415e-03
## C14.1_T2           5.809916e-03 -3.498766e-03 -7.055632e-04  3.970351e-03
## C14.2_T2           3.558564e-03 -1.937667e-03 -1.378428e-03  3.740500e-03
## C16.1_T2           3.265353e-03 -2.719691e-03 -1.348313e-03  3.051986e-03
## C16.2_T2           2.587774e-03 -2.507386e-03 -1.249875e-03  2.733849e-03
## C16.2.OH_T2        2.079065e-03 -2.238689e-03 -1.578909e-03  2.644854e-03
## C18.1_T2           4.683054e-03 -5.545155e-03 -3.635516e-03  4.841087e-04
## C18.1.OH_T2        3.285175e-03 -2.760585e-03 -1.727340e-03  2.754006e-03
## C18.2_T2           4.335498e-03 -2.678537e-03 -5.153155e-03  2.314459e-03
## lysoPC.a.C14.0_T2 -9.458924e-03 -1.130885e-02  1.061336e-02 -1.509022e-02
## lysoPC.a.C16.0_T2  7.218195e-02  2.165287e-03 -4.093626e-02 -3.953906e-03
## lysoPC.a.C16.1_T2  8.665180e-03 -1.265518e-02  1.532068e-02 -1.175359e-02
## lysoPC.a.C17.0_T2  1.569421e-02  8.351613e-04 -8.631425e-03  1.758355e-03
## lysoPC.a.C18.0_T2  5.312906e-02 -1.565574e-02 -3.739553e-03 -5.346418e-02
## lysoPC.a.C18.1_T2  6.040689e-02 -8.298299e-03  1.448888e-02 -1.969357e-03
## lysoPC.a.C18.2_T2  1.295025e-01  8.255837e-02 -8.694193e-02  5.661706e-02
## lysoPC.a.C20.3_T2  1.035077e-02 -1.245017e-02  2.547000e-02 -6.414805e-04
## lysoPC.a.C20.4_T2  4.921307e-02  1.551366e-02 -5.555328e-02 -2.080461e-02
## lysoPC.a.C24.0_T2  1.538288e-03 -4.794982e-03 -3.560304e-03  6.409333e-03
## lysoPC.a.C26.0_T2 -5.021060e-02 -1.514955e-01 -9.414812e-03  1.168179e-01
## lysoPC.a.C26.1_T2 -6.272059e-03 -7.441298e-03 -6.215195e-03  4.297928e-03
## lysoPC.a.C28.0_T2 -7.007297e-02 -4.080513e-03  1.361308e-02 -2.071638e-02
## lysoPC.a.C28.1_T2  1.531585e-03 -9.513638e-03 -1.765673e-03  5.117582e-03
## PC.aa.C24.0_T2     3.594537e-03 -7.208285e-02 -4.243514e-02 -3.313250e-02
## PC.aa.C28.1_T2     6.189109e-05  3.009233e-02 -1.484193e-02  2.557936e-02
## PC.aa.C30.0_T2    -1.513970e-03  7.526320e-03 -4.720736e-03  2.101249e-02
## PC.aa.C32.0_T2    -1.068860e-02 -7.050237e-03 -5.254563e-02  8.734308e-02
## PC.aa.C32.1_T2    -3.395525e-02 -2.174594e-02  4.532836e-02  4.167086e-02
## PC.aa.C32.3_T2     4.888051e-03 -2.329118e-03 -9.813251e-04  6.136585e-04
## PC.aa.C34.1_T2    -6.980173e-04 -5.497794e-02  3.682742e-02  5.548531e-02
## PC.aa.C34.2_T2     1.100421e-01 -3.512901e-02 -7.555538e-02  3.715253e-02
## PC.aa.C34.3_T2     2.778522e-02 -1.692193e-02  2.464009e-02  1.013502e-02
## PC.aa.C34.4_T2     1.738189e-03 -1.570687e-03  1.226521e-03  1.279445e-03
## PC.aa.C36.0_T2     2.254494e-02  8.258316e-03 -3.178536e-03  1.419171e-02
## PC.aa.C36.1_T2    -3.678256e-02 -4.506899e-02  5.278968e-02 -2.547887e-02
## PC.aa.C36.2_T2     5.026118e-02  1.020173e-02  3.427028e-02 -2.636189e-02
## PC.aa.C36.3_T2    -2.184962e-03 -6.691745e-02  5.601544e-02 -3.032912e-02
## PC.aa.C36.4_T2     1.972463e-02 -4.564738e-02  1.863566e-02 -7.138577e-02
## PC.aa.C36.5_T2     5.077912e-02  2.145242e-02 -3.306522e-02  5.454270e-02
## PC.aa.C38.0_T2    -1.448840e-02 -1.757968e-03 -3.768180e-03  6.642462e-04
## PC.aa.C38.1_T2     2.974122e-02  1.763903e-02 -1.426676e-02  2.162158e-02
## PC.aa.C38.3_T2    -1.051315e-02 -3.948858e-02  6.852043e-02 -3.115052e-02
## PC.aa.C38.4_T2     1.107232e-02 -7.356897e-02  6.899774e-02 -9.736762e-02
## PC.aa.C38.5_T2     4.117568e-02 -5.428246e-02  2.391607e-02 -1.109075e-02
## PC.aa.C38.6_T2     5.960159e-02 -4.094345e-02 -6.559571e-02 -1.124812e-02
## PC.aa.C40.1_T2     4.346464e-02 -1.635888e-01 -4.360089e-02 -6.425776e-02
## PC.aa.C40.2_T2     1.358794e-02 -1.034088e-02 -2.064639e-03  1.103148e-02
## PC.aa.C40.3_T2     1.389258e-02 -6.506192e-03 -3.352760e-04  7.699377e-03
## PC.aa.C40.4_T2     1.725314e-03 -1.601053e-02  2.387371e-02 -1.719349e-03
## PC.aa.C40.5_T2     4.587904e-03 -3.588345e-02  6.043888e-02 -1.617522e-02
## PC.aa.C40.6_T2     2.548853e-02 -8.371938e-03 -4.098232e-02 -3.424131e-02
## PC.aa.C42.0_T2    -1.454964e-03  8.294015e-04 -5.954905e-03  5.028339e-03
## PC.aa.C42.1_T2     5.334015e-03 -1.215300e-03 -3.481761e-03  3.508012e-03
## PC.aa.C42.2_T2     6.257972e-03 -2.051431e-03 -1.574913e-03  7.416852e-03
## PC.aa.C42.4_T2     2.500655e-03 -4.452092e-03 -2.174821e-03  5.933997e-03
## PC.aa.C42.5_T2     4.241132e-03 -2.740264e-03 -2.590981e-03  4.780854e-03
## PC.aa.C42.6_T2    -7.304794e-02  1.918219e-05 -1.188027e-01 -3.383129e-02
## PC.ae.C30.0_T2    -9.740284e-02  8.252149e-02  3.422521e-02 -2.848148e-02
## PC.ae.C32.1_T2    -2.404023e-02  6.029461e-03  6.094501e-03  1.003936e-02
## PC.ae.C32.2_T2     1.610532e-03 -4.838884e-03 -3.061818e-03  2.127775e-03
## PC.ae.C34.0_T2     4.029970e-03  4.655621e-03 -2.513155e-03  4.785351e-03
## PC.ae.C34.1_T2    -4.482871e-02 -3.548230e-02  1.976570e-02 -6.724454e-03
## PC.ae.C34.2_T2    -2.117748e-02 -8.920882e-03  1.179441e-02  1.810135e-02
## PC.ae.C34.3_T2     2.375628e-03  5.755991e-03 -2.324995e-02  2.912792e-02
## PC.ae.C36.0_T2     3.487075e-03 -2.956396e-03 -2.506002e-03  1.513722e-02
## PC.ae.C36.1_T2     3.348839e-02 -1.327340e-02  2.297312e-03  2.996057e-02
## PC.ae.C36.2_T2     2.624234e-02 -1.055291e-02  1.745879e-02 -5.823491e-03
## PC.ae.C36.3_T2    -1.708139e-02 -1.602396e-02 -1.558933e-05 -3.178289e-04
## PC.ae.C36.4_T2    -3.592283e-02  5.937461e-03  2.139499e-02  5.784454e-03
## PC.ae.C36.5_T2    -2.231031e-02  1.094410e-03  1.532238e-02  1.220323e-03
## PC.ae.C38.0_T2     1.328339e-02  1.437817e-05 -3.256741e-03  1.079965e-03
## PC.ae.C38.2_T2     2.259013e-02 -1.348594e-02 -1.007522e-02  2.546297e-02
## PC.ae.C38.3_T2     1.430428e-02 -8.371109e-03  3.218888e-03  1.702377e-02
## PC.ae.C38.4_T2    -2.768821e-02 -4.241398e-03  2.685023e-02 -2.948562e-02
## PC.ae.C38.5_T2    -3.650464e-02  2.342516e-02  3.485456e-02 -3.768278e-02
## PC.ae.C38.6_T2    -2.546659e-03 -6.259347e-03  1.131070e-02 -8.534075e-03
## PC.ae.C40.1_T2     2.185674e-02 -6.718110e-03 -3.477198e-03  1.011883e-02
## PC.ae.C40.2_T2     4.276365e-04  5.837607e-03 -1.131886e-02  7.904521e-03
## PC.ae.C40.3_T2     9.430491e-03 -5.625749e-03 -7.128866e-03  1.496590e-02
## PC.ae.C40.4_T2    -3.460634e-03  2.168179e-03  2.222651e-03  5.496605e-04
## PC.ae.C40.5_T2    -1.955950e-02  5.664610e-03  8.645316e-03 -6.229016e-03
## PC.ae.C40.6_T2    -3.493355e-03 -6.485535e-04 -1.187230e-04 -1.379061e-02
## PC.ae.C42.1_T2     1.194923e-02 -7.877520e-03 -2.398041e-03  6.455953e-03
## PC.ae.C42.2_T2     9.192776e-03 -6.136224e-03 -2.886363e-03  7.420195e-03
## PC.ae.C42.3_T2     1.377387e-02 -3.708712e-03 -1.288525e-02  6.272293e-03
## PC.ae.C42.4_T2    -3.276609e-03  4.332534e-03  4.157020e-04  6.021572e-03
## PC.ae.C42.5_T2    -3.636636e-02  8.645520e-03 -6.959770e-03 -2.184907e-02
## PC.ae.C44.3_T2     2.227203e-02 -1.968462e-02  2.165980e-02  3.289356e-02
## PC.ae.C44.4_T2    -3.581303e-03 -1.829357e-03 -6.962391e-03  5.974860e-03
## PC.ae.C44.5_T2    -2.269063e-02  1.094323e-02 -1.543354e-02 -9.053648e-03
## PC.ae.C44.6_T2    -1.017566e-02  1.159292e-02 -1.668212e-02 -6.555222e-03
## SM..OH..C14.1_T2  -1.421702e-02  2.989212e-02  4.427754e-05  2.544525e-02
## SM..OH..C16.1_T2  -9.128909e-03  1.003855e-02 -5.007513e-03  2.623212e-03
## SM..OH..C22.1_T2  -2.030412e-02 -1.314206e-03 -1.926612e-03 -4.301213e-03
## SM..OH..C22.2_T2  -3.112154e-02 -1.890028e-03  4.825164e-03 -1.718870e-02
## SM..OH..C24.1_T2  -2.298941e-03  2.052607e-04 -4.082351e-03  6.138651e-04
## SM.C16.0_T2       -2.985974e-02  6.203384e-02 -2.749436e-02  9.977794e-02
## SM.C16.1_T2        4.458047e-02  3.163078e-02  1.069164e-02  1.329155e-02
## SM.C18.0_T2       -1.330546e-02  2.240846e-02 -2.750105e-02  1.409582e-02
## SM.C18.1_T2        1.160084e-02  3.669603e-03 -3.171694e-02 -4.786518e-02
## SM.C20.2_T2        6.014312e-04 -2.202504e-03 -2.367688e-03  2.055381e-03
## SM.C24.0_T2       -1.526035e-02  1.387457e-02 -3.239311e-02  7.545180e-02
## SM.C24.1_T2       -4.475323e-02  3.925708e-02 -8.052957e-02  5.086350e-02
## MEDDM_T4          -1.600437e-03 -3.158207e-03 -2.321748e-03  2.924357e-03
## MEDCOL_T4          4.538998e-03 -8.824277e-05  7.085685e-03  6.316160e-03
## MEDINF_T4          1.304325e-02  1.725163e-02 -9.676649e-03 -7.921124e-03
## MEDHTA_T4          6.521952e-03  2.314149e-02 -7.898426e-03  1.386024e-02
## GLU_T4            -4.921426e-02 -7.009814e-03  3.983574e-03  3.429229e-03
## INS_T4            -1.653541e-01 -8.850885e-02 -2.823406e-02 -3.477197e-02
## HOMA_T4           -5.944794e-02 -3.199971e-02 -1.359061e-02 -6.687560e-03
## HBA1C_T4          -9.272345e-04  1.093657e-02  7.055293e-03 -1.238532e-02
## HBA1C.mmol.mol_T4  8.932764e-03  4.617307e-02  2.815475e-02 -5.076108e-02
## PESO_T4            3.940905e-02 -3.097104e-02  3.833462e-02  2.721196e-02
## bmi_T4             3.421309e-02 -1.309618e-02  1.130565e-01  4.670757e-02
## CC_T4             -3.721446e-03 -7.700943e-03 -7.355845e-04 -1.302431e-03
## CINT_T4           -6.347752e-02 -5.182826e-02  1.685824e-02  2.106046e-02
## CAD_T4            -1.405526e-02  1.063380e-02  3.185726e-03  6.459644e-02
## TAD_T4            -4.571172e-02  8.372618e-02 -4.920902e-02  1.299523e-01
## TAS_T4             7.224245e-02  2.965270e-02 -5.427674e-02  2.231433e-02
## TG_T4             -2.082365e-02  1.695977e-02  2.381051e-03 -4.968155e-03
## COL_T4            -2.073306e-02  7.865127e-03  7.248325e-02  7.836895e-03
## LDL_T4            -3.133055e-02 -2.519409e-02  8.297498e-02  3.932640e-02
## HDL_T4             9.259855e-03  4.356182e-02  2.648833e-02 -3.599558e-02
## VLDL_T4           -9.434502e-02  8.641345e-03 -9.747899e-03 -5.398595e-02
## PCR_T4            -1.691426e-03 -1.379296e-01 -6.854486e-02 -2.458949e-02
## LEP_T4             7.560696e-02  8.752211e-02 -1.052157e-01 -9.788118e-02
## ADIPO_T4          -7.297401e-02 -1.038839e-02  2.056991e-02 -2.176299e-02
## GOT_T4            -6.027211e-02 -1.043736e-01 -2.307141e-02 -1.019590e-03
## GPT_T4            -2.774868e-02 -3.393208e-02  1.885792e-02  5.889415e-02
## GGT_T4             7.002903e-02  1.325877e-01 -2.030739e-01 -1.645317e-02
## URICO_T4          -3.458830e-02 -7.918033e-02 -1.039450e-01 -1.281032e-03
## CREAT_T4           5.311662e-03 -1.030198e-02  1.659291e-03  5.049302e-03
## UREA_T4           -8.653620e-03  3.858921e-02 -2.657385e-03  2.126116e-02
## HIERRO_T4         -4.965722e-02  7.879370e-03 -8.505779e-03 -1.827753e-02
## TRANSF_T4         -5.636245e-02 -1.920323e-02 -7.010401e-02  1.550246e-02
## FERR_T4           -2.452751e-02 -9.256441e-02 -4.505062e-02 -2.896964e-03
## Ile_T4            -4.660678e-02 -7.611785e-02  3.528492e-02  2.608775e-02
## Leu_T4             1.728129e-02 -2.595442e-02 -8.716304e-03  2.710942e-02
## Val_T4             2.081774e-03 -4.813208e-02  1.922149e-02 -3.306431e-02
## Ala_T4             1.336653e-02 -1.563246e-02  7.113935e-02  6.855911e-02
## Pro_T4            -2.883450e-02  5.674346e-02  1.163350e-01  4.025340e-02
## Gly_T4            -4.246759e-02  3.790522e-03 -2.436069e-02 -8.773170e-04
## Ser_T4            -2.050485e-02  7.388130e-02  2.273140e-03  7.100258e-02
## Trp_T4            -1.217771e-02 -3.496348e-02 -2.875801e-02 -3.005239e-02
## Phe_T4             8.821827e-02  2.585917e-02  2.646442e-02  1.132177e-02
## Met_T4             4.182166e-02  1.077954e-02  3.026729e-02  1.059442e-03
## Orn_T4             1.541962e-02 -9.791146e-02  3.290255e-02 -2.182921e-02
## Arg_T4             4.643117e-02 -1.492571e-02 -2.050039e-02  3.981656e-02
## His_T4             5.992484e-02 -2.708031e-02  3.810857e-02  2.590189e-02
## Asn_T4             2.002470e-02 -1.800838e-02 -1.386367e-02  2.908530e-02
## Asp_T4            -2.795292e-02 -1.095431e-02 -1.021671e-01 -1.556914e-02
## Glu_T4            -1.497819e-02  1.920032e-02 -5.649953e-02 -3.672160e-02
## Gln_T4            -1.689278e-02 -5.345542e-03 -7.481553e-03  6.657152e-02
## Cit_T4            -7.964156e-02 -1.350393e-02  1.976192e-02 -3.560009e-02
## Tyr_T4             1.675295e-02 -4.361453e-02  5.339191e-02  2.466228e-02
## Thr_T4            -1.334614e-02 -5.372407e-02 -6.227500e-02 -1.060384e-02
## Lys_T4             5.606753e-02  2.157416e-02  1.356110e-02  4.606691e-02
## Creatinine_T4     -5.761267e-02 -2.360550e-03 -5.624324e-02  3.887449e-02
## Kynurenine_T4      4.094237e-02  4.295720e-02 -1.239762e-02 -8.232242e-03
## Putrescine_T4      2.383727e-02  2.077736e-03  4.817670e-02 -5.236184e-02
## Sarcosine_T4      -1.150725e-01 -6.156430e-02  2.535994e-01  5.992698e-02
## Serotonin_T4       3.181369e-03  1.742548e-02  1.326357e-04  4.451938e-02
## Taurine_T4        -8.974711e-02 -4.732461e-03  2.850454e-02 -9.378159e-03
## SDMA_T4           -3.925797e-03  6.177070e-03 -7.340829e-03 -3.259422e-03
## C0_T4             -1.231772e-02 -6.061596e-02 -1.118966e-02 -2.491219e-02
## C2_T4              2.595938e-02 -2.391441e-02  1.205669e-03  1.426413e-02
## C3.OH_T4           9.582040e-03 -3.401693e-03  1.071001e-03 -1.520822e-03
## C6..C4.1.DC._T4    1.830586e-02  2.037618e-01  4.681771e-02 -1.026149e-02
## C5.DC..C6.OH._T4   2.024774e-02  1.553347e-01  9.957889e-02 -7.405435e-02
## C7.DC_T4          -3.386637e-02  1.226856e-01  8.701971e-02 -1.106104e-01
## C8_T4              1.453438e-02  3.774238e-03 -1.528850e-03 -6.736945e-04
## C10_T4             1.058426e-02  3.495542e-03 -2.761809e-03  4.558758e-03
## C10.1_T4           5.612448e-03 -2.849661e-03 -2.143731e-03  1.053605e-03
## C10.2_T4           4.823004e-03 -1.158187e-03  7.928496e-04  1.808280e-03
## C14.1_T4           7.282751e-03  6.428245e-05 -3.148795e-03  2.257086e-03
## C14.2_T4           5.858694e-03 -2.182051e-03 -1.375058e-03  1.959070e-03
## C16.1_T4           5.686312e-02  3.149301e-02  6.133650e-02 -6.454650e-02
## C16.2_T4           4.280604e-03 -1.995368e-03 -1.939728e-03  2.675367e-03
## C16.2.OH_T4        5.535980e-02  2.988960e-02  6.108436e-02 -6.390740e-02
## C18.1_T4           4.053500e-03 -3.186287e-03 -3.357790e-03  2.129129e-03
## C18.1.OH_T4        3.695947e-03 -2.592175e-03 -1.895648e-03  2.310735e-03
## C18.2_T4           4.959015e-03 -2.977276e-03 -2.590920e-03  2.132109e-03
## lysoPC.a.C16.0_T4  7.502465e-02 -6.204233e-02 -4.329579e-02 -4.919559e-03
## lysoPC.a.C16.1_T4  4.437699e-02 -5.011678e-03  1.451368e-03 -4.538676e-03
## lysoPC.a.C17.0_T4  1.118164e-02 -1.973645e-02  9.496177e-03 -1.011922e-02
## lysoPC.a.C18.0_T4  3.779568e-02 -7.261444e-02 -5.871279e-02 -6.303536e-02
## lysoPC.a.C18.1_T4  3.122253e-02 -2.516714e-02 -3.429777e-02 -1.428407e-02
## lysoPC.a.C18.2_T4  1.781910e-02 -8.091116e-02 -5.379508e-02  1.036648e-02
## lysoPC.a.C20.3_T4 -1.303882e-02 -5.734536e-03 -2.026632e-02  3.164008e-02
## lysoPC.a.C20.4_T4  2.742801e-03 -9.958965e-03  2.126689e-03  1.997688e-02
## lysoPC.a.C24.0_T4  7.560841e-03  2.392890e-03 -1.270847e-03  3.626729e-04
## lysoPC.a.C26.0_T4  1.992055e-01  3.456238e-02  7.285507e-02  1.921736e-02
## lysoPC.a.C26.1_T4  1.092370e-02 -3.746980e-03  3.168661e-03  2.079154e-03
## lysoPC.a.C28.0_T4  4.415653e-02 -6.398170e-02  1.603632e-03 -9.852624e-02
## lysoPC.a.C28.1_T4  5.286393e-03  4.026612e-03  5.655780e-03  1.755369e-03
## PC.aa.C24.0_T4     1.207526e-01 -1.420696e-02  8.412247e-02 -1.962857e-03
## PC.aa.C28.1_T4     1.195921e-02  6.389590e-02  2.606601e-02 -1.197902e-02
## PC.aa.C30.0_T4    -3.694027e-03  2.019425e-02  2.318341e-02  2.476682e-02
## PC.aa.C32.0_T4    -4.911552e-02  4.540645e-02  1.283022e-02  2.795536e-02
## PC.aa.C32.1_T4    -3.627541e-02  4.697518e-02 -4.722837e-03  3.265280e-02
## PC.aa.C32.3_T4     1.162725e-03 -2.192692e-03  2.476939e-03  2.792404e-03
## PC.aa.C34.1_T4    -2.640936e-02  2.694426e-02 -1.994352e-03 -1.158220e-02
## PC.aa.C34.2_T4    -2.641827e-02 -4.571572e-02 -4.806278e-02 -1.135300e-02
## PC.aa.C34.3_T4    -4.979614e-03 -2.138475e-02 -5.015518e-04  7.467100e-03
## PC.aa.C34.4_T4     1.122445e-03 -1.440784e-03  9.446882e-03  2.604950e-03
## PC.aa.C36.0_T4    -4.321704e-03 -4.305370e-03 -1.419287e-02  4.682787e-03
## PC.aa.C36.1_T4    -5.112616e-02  8.776787e-02  1.012895e-02 -5.537358e-02
## PC.aa.C36.2_T4    -2.358626e-02  1.508495e-02 -6.323706e-03 -6.835054e-02
## PC.aa.C36.3_T4    -7.417754e-03 -3.268962e-03  2.450814e-04  1.075855e-02
## PC.aa.C36.4_T4    -3.096113e-02  2.882766e-03  5.806553e-02  1.543227e-02
## PC.aa.C36.5_T4    -1.330065e-02 -5.046270e-02  1.855757e-03 -1.599423e-02
## PC.aa.C38.0_T4    -4.430949e-04  8.811225e-03 -1.072204e-02 -8.763049e-03
## PC.aa.C38.1_T4    -2.578856e-02 -1.412691e-02 -5.474060e-03 -7.602649e-03
## PC.aa.C38.3_T4    -2.179157e-02  5.213778e-02  1.320121e-02  4.569272e-02
## PC.aa.C38.4_T4    -3.846277e-02 -8.198260e-03  6.240436e-02 -5.921354e-03
## PC.aa.C38.5_T4    -5.128103e-05  3.912776e-03  4.801522e-03 -3.728800e-03
## PC.aa.C38.6_T4    -2.312289e-02 -4.431893e-02 -2.211529e-02 -1.257685e-02
## PC.aa.C40.1_T4     9.675964e-02 -3.347610e-02 -1.400629e-01 -3.304715e-02
## PC.aa.C40.2_T4    -6.505588e-03  1.179774e-03 -8.830938e-04  4.894653e-03
## PC.aa.C40.3_T4    -1.719179e-03  3.191162e-03 -5.341906e-03  5.798385e-03
## PC.aa.C40.4_T4     1.212428e-02  2.946254e-02  1.180934e-02 -7.817479e-03
## PC.aa.C40.5_T4     6.812390e-03  1.148469e-02  2.119952e-02 -8.921470e-03
## PC.aa.C40.6_T4    -2.073451e-02 -2.662811e-02 -2.243670e-02 -4.003033e-02
## PC.aa.C42.0_T4    -2.958893e-03  9.734709e-04 -1.923715e-03  2.917940e-03
## PC.aa.C42.1_T4     1.295215e-03  1.874134e-03 -2.057167e-03  3.700820e-03
## PC.aa.C42.2_T4    -2.543814e-03  1.262108e-03 -8.276287e-04  2.550343e-04
## PC.aa.C42.4_T4    -1.072016e-03 -2.624526e-04 -6.441553e-04  1.291471e-03
## PC.aa.C42.5_T4     1.333048e-03  1.722367e-03 -1.243373e-03  6.600405e-05
## PC.aa.C42.6_T4     5.033167e-02  9.500686e-02  9.943712e-03  6.760756e-02
## PC.ae.C30.0_T4     2.784298e-02  5.815573e-02 -2.685886e-02  5.135484e-02
## PC.ae.C32.1_T4    -8.855390e-03  9.778502e-03  1.901080e-02  1.756055e-03
## PC.ae.C32.2_T4    -4.356185e-04  1.554569e-03 -9.964229e-04 -1.237623e-03
## PC.ae.C34.0_T4    -6.317192e-04  1.811205e-03  5.312508e-03  3.348434e-03
## PC.ae.C34.1_T4    -3.899317e-02  4.569744e-02  2.897851e-02  4.488242e-03
## PC.ae.C34.2_T4     6.664254e-03  2.366688e-02  1.170599e-03 -8.812769e-03
## PC.ae.C34.3_T4    -2.194117e-03 -5.202386e-03 -7.719254e-03  1.673487e-03
## PC.ae.C36.0_T4    -1.955793e-03  1.265743e-03 -4.554129e-03 -1.287918e-03
## PC.ae.C36.1_T4    -4.040160e-02  4.728696e-02  3.380432e-02 -8.469958e-03
## PC.ae.C36.2_T4    -1.984019e-02  1.489487e-03  2.257515e-02 -3.421286e-03
## PC.ae.C36.3_T4     1.068129e-02  6.443674e-03 -6.846794e-03  4.517690e-03
## PC.ae.C36.4_T4     3.396106e-02  2.570873e-02  3.098083e-03  4.139593e-03
## PC.ae.C36.5_T4    -1.622579e-02  3.449021e-02 -1.594009e-04 -2.268382e-02
## PC.ae.C38.0_T4     1.527796e-03 -8.499455e-03 -1.212830e-02 -9.051796e-03
## PC.ae.C38.2_T4    -2.545966e-02  2.993224e-03  6.759060e-03 -5.728060e-03
## PC.ae.C38.3_T4    -3.429049e-02  1.191930e-02 -1.837537e-05  1.544827e-02
## PC.ae.C38.4_T4    -3.490734e-02  4.936183e-02  4.032015e-02  2.505535e-03
## PC.ae.C38.5_T4     3.236537e-02  5.261082e-02  1.737374e-02 -1.426752e-02
## PC.ae.C38.6_T4     2.525562e-02  1.857283e-02  7.286349e-03 -1.819709e-02
## PC.ae.C40.1_T4    -4.775381e-04 -1.233492e-02 -5.699716e-05 -3.158003e-03
## PC.ae.C40.2_T4    -2.010606e-02  2.730191e-02  8.078435e-03  8.841762e-03
## PC.ae.C40.3_T4    -3.021891e-02  4.574039e-03  8.497268e-04  9.897639e-03
## PC.ae.C40.4_T4    -3.197644e-02  2.905206e-02  6.131070e-03 -1.812997e-03
## PC.ae.C40.5_T4    -2.361723e-02  2.910520e-02  9.090541e-03  2.060350e-03
## PC.ae.C40.6_T4    -2.975601e-03  7.641773e-03  5.428278e-03 -4.556518e-03
## PC.ae.C42.1_T4    -4.843676e-04 -3.522996e-03 -1.368652e-03  3.549177e-03
## PC.ae.C42.2_T4     1.364168e-03 -7.114321e-03 -3.093848e-03  5.772239e-03
## PC.ae.C42.3_T4    -1.328188e-03 -2.513758e-03 -2.049090e-03 -9.002504e-05
## PC.ae.C42.4_T4    -3.565436e-04  6.984332e-03  1.556011e-03 -1.995792e-03
## PC.ae.C42.5_T4    -1.583578e-02  1.981641e-02  1.426394e-02  6.132171e-04
## PC.ae.C44.3_T4    -2.931660e-05  2.140661e-04 -7.642360e-04  1.098241e-03
## PC.ae.C44.4_T4     7.600113e-04 -1.938337e-03 -1.033471e-03  2.456895e-03
## PC.ae.C44.5_T4     5.882511e-03  1.116060e-02  3.117408e-03 -3.089450e-03
## PC.ae.C44.6_T4    -9.508869e-04  1.469644e-02 -2.466235e-03  2.258728e-05
## SM..OH..C14.1_T4  -1.542697e-02  7.002952e-02  1.983956e-02 -1.705411e-02
## SM..OH..C16.1_T4  -1.379534e-02  3.588198e-02  1.847949e-03 -2.921447e-04
## SM..OH..C22.1_T4  -2.151326e-02  3.425312e-02 -2.459473e-02 -3.499432e-02
## SM..OH..C22.2_T4  -3.974369e-02  7.286604e-02  1.421135e-03  6.179643e-03
## SM..OH..C24.1_T4   9.928929e-04  1.517957e-03 -3.572265e-03  2.806066e-03
## SM.C16.0_T4       -1.134834e-02  6.174445e-02 -1.025548e-02  1.822182e-03
## SM.C16.1_T4        5.045642e-03  5.998958e-02  2.523099e-02 -5.777156e-03
## SM.C18.0_T4       -1.378445e-02  5.567233e-02  8.116304e-03  9.464677e-02
## SM.C18.1_T4        4.854515e-03  4.333883e-02  9.222658e-03  6.742431e-02
## SM.C20.2_T4        1.572441e-03 -6.764162e-05  2.570329e-03  6.081300e-03
## SM.C24.0_T4        8.498707e-03  7.228352e-02 -9.737863e-02 -2.733304e-02
## SM.C24.1_T4       -2.408041e-02  5.788023e-02 -3.911175e-02  8.341998e-02
## MEDDM_T5          -2.485949e-02  5.337201e-04 -9.345236e-03  1.251720e-02
## MEDCOL_T5         -2.485949e-02  5.337201e-04 -9.345236e-03  1.251720e-02
## MEDINF_T5         -1.048899e-02  1.977233e-02 -1.441494e-02  2.668031e-03
## MEDHTA_T5         -2.918376e-02  2.999828e-04 -1.017317e-02  1.323304e-02
## GLU_T5            -3.952935e-02  1.037616e-01 -5.266658e-03 -4.256215e-02
## INS_T5             8.395506e-02  6.624412e-02  4.408855e-02  1.831092e-02
## HOMA_T5            2.687709e-02  3.086458e-02  1.562355e-02  7.544188e-03
## HBA1C_T5          -5.793288e-03 -1.092596e-02 -7.588497e-03 -6.583269e-03
## HBA1C.mmol.mol_T5 -7.680488e-03 -2.833376e-02 -2.176754e-02 -3.148078e-02
## PESO_T5            2.906036e-02  4.643013e-02 -4.478437e-02  7.263127e-03
## bmi_T5             3.824518e-02  4.744518e-02 -8.318167e-03  6.341292e-03
## CC_T5              1.238147e-03 -2.140287e-03 -9.805890e-04 -2.261526e-03
## CINT_T5            7.231680e-03 -7.759999e-04 -4.462431e-02 -5.264374e-02
## CAD_T5             1.597828e-02  2.252583e-02 -2.621522e-02 -1.351566e-02
## TAD_T5            -1.960856e-03 -1.460174e-02  2.168666e-02  1.001229e-01
## TAS_T5             1.021284e-01  4.844299e-02 -3.775842e-02  9.063098e-03
## TG_T5             -2.577068e-02  6.992093e-02  5.405626e-03  3.745560e-03
## COL_T5            -2.873694e-02  3.389710e-02  3.114222e-02  5.926752e-02
## LDL_T5            -5.006949e-02  6.669428e-02  3.946045e-02  1.186871e-01
## HDL_T5             3.236660e-02 -6.538525e-02  3.295400e-03 -8.332770e-02
## VLDL_T5            9.604219e-03  1.606829e-02 -8.197180e-03 -1.099809e-02
## PCR_T5            -4.642461e-02 -3.640538e-02  7.671201e-02  3.031617e-02
## LEP_T5            -9.095652e-03  1.002778e-02 -2.487577e-02 -2.430228e-02
## ADIPO_T5          -5.256111e-02  3.200255e-03  1.770469e-02 -5.630951e-02
## GOT_T5            -3.996897e-02 -5.378180e-02  2.533926e-02 -5.661530e-03
## GPT_T5            -4.114532e-02 -9.170978e-03  1.101875e-01 -3.952310e-02
## GGT_T5             9.280545e-03  5.046701e-02 -8.710431e-02 -7.328212e-02
## URICO_T5          -2.500309e-02 -1.190546e-02 -5.669855e-02  8.849328e-03
## CREAT_T5          -3.593772e-04 -5.946997e-03 -6.053251e-03  6.503241e-03
## UREA_T5           -5.671266e-02  1.125324e-01 -2.051999e-02 -5.495309e-02
## HIERRO_T5          7.946052e-02 -3.492703e-03 -1.060768e-01  1.184823e-01
## TRANSF_T5         -5.675325e-02 -4.045847e-02 -2.349192e-02 -1.028695e-01
## FERR_T5            4.061778e-02  1.775466e-01 -3.408837e-02  4.493310e-02
## Ile_T5            -4.744230e-03  3.416190e-02  2.158775e-02  4.934370e-02
## Leu_T5             5.538367e-02  1.002973e-01 -2.474982e-02  2.825418e-02
## Val_T5             4.637766e-02  7.400654e-02 -2.282763e-02 -1.937136e-02
## Ala_T5            -1.242582e-02  2.085098e-02  2.978261e-02 -2.297073e-02
## Pro_T5            -4.515079e-02  5.507216e-02 -7.768863e-02 -6.946743e-02
## Gly_T5            -7.603728e-02 -2.309965e-02  6.282186e-04 -3.719495e-02
## Ser_T5             5.185764e-02  1.512557e-02  4.299579e-02 -2.213074e-02
## Trp_T5            -3.648639e-02 -8.089512e-03 -4.093965e-02 -1.845521e-02
## Phe_T5             2.935593e-02  4.240630e-02 -3.499738e-02 -6.556592e-02
## Met_T5             1.504686e-02  2.032075e-02 -2.329733e-02  4.407792e-02
## Orn_T5             1.470236e-02  7.378849e-02  2.373897e-02  2.829111e-02
## Arg_T5             1.445974e-02 -1.435278e-02  3.284360e-02  3.081044e-02
## His_T5            -2.675205e-02  1.299772e-02  5.569801e-02 -1.115980e-03
## Asn_T5             1.829372e-02 -1.391727e-02  6.854081e-02  1.111630e-02
## Asp_T5             9.575048e-03 -2.319255e-03  5.760203e-02 -1.994282e-02
## Glu_T5            -3.767578e-02 -1.472833e-02 -7.297185e-03  4.336002e-03
## Gln_T5             2.180545e-02  2.247513e-02  1.352163e-02 -2.296067e-02
## Cit_T5            -9.114602e-03  4.293070e-02  7.295185e-02  8.699757e-02
## Tyr_T5             1.813067e-02  6.752204e-03 -2.339712e-02  5.721315e-02
## Thr_T5            -2.889878e-02  2.230385e-02 -1.356296e-03 -5.512957e-02
## Lys_T5             6.275206e-02  7.557063e-02 -1.298873e-02  3.592717e-02
## Creatinine_T5     -1.239497e-02 -4.353115e-02 -5.551739e-02 -1.633700e-02
## Kynurenine_T5      2.201459e-02 -2.415973e-02  3.147094e-03  3.280698e-02
## Putrescine_T5     -7.771913e-02 -1.534178e-01 -2.537161e-02 -2.860440e-02
## Sarcosine_T5      -4.223474e-02 -3.931695e-02 -6.288087e-02 -1.711198e-02
## Serotonin_T5       1.500398e-02  7.218701e-02  6.833577e-03  2.940885e-02
## Taurine_T5         5.222365e-02  1.997622e-02 -5.136268e-02  2.681216e-03
## SDMA_T5           -8.097363e-04 -1.048345e-02 -5.619691e-03  2.116106e-03
## C0_T5              2.918709e-02  1.268671e-02 -4.663900e-02  1.405489e-04
## C2_T5              9.478820e-02 -5.249990e-02 -9.149130e-03  7.070315e-02
## C3.OH_T5           4.760343e-03 -1.601900e-03 -2.083323e-03 -1.133961e-03
## C6..C4.1.DC._T5    1.103696e-01  4.863310e-03  2.477830e-02  5.658258e-03
## C5.DC..C6.OH._T5   8.916492e-03  3.611930e-02  1.204673e-03  1.690111e-02
## C7.DC_T5           1.422211e-01 -2.623692e-02  9.061294e-02 -1.090740e-01
## C8_T5              1.065212e-02 -1.783245e-03 -4.476857e-03 -3.510608e-03
## C10_T5             1.289614e-02 -3.779227e-03 -6.250086e-03 -5.252513e-03
## C10.1_T5           3.343081e-02  1.165616e-02 -6.084810e-02 -1.293383e-02
## C10.2_T5           3.900630e-03 -2.050299e-03 -2.304963e-03  1.047730e-03
## C14.1_T5           5.226767e-03 -3.479450e-03 -2.958332e-03  1.317049e-03
## C14.2_T5           4.554015e-03 -2.814851e-03 -1.649126e-03  1.565950e-03
## C16.1_T5           3.647501e-03 -2.105469e-03 -1.477443e-03  1.911557e-03
## C16.2_T5           2.441999e-03 -3.122082e-03 -1.504574e-03  2.363438e-03
## C16.2.OH_T5       -4.064277e-02  1.025247e-02  1.145325e-02 -2.562320e-02
## C18.1_T5           3.415150e-03 -2.654211e-03 -2.036843e-03  3.174203e-03
## C18.1.OH_T5        2.876833e-03 -3.090390e-03 -1.440556e-03  2.384567e-03
## C18.2_T5           3.873392e-03 -2.523847e-03 -1.718223e-03  2.091942e-03
## lysoPC.a.C16.0_T5 -2.447750e-03 -1.574072e-02  3.961046e-02 -3.735949e-03
## lysoPC.a.C16.1_T5  1.337761e-02  1.798634e-02  2.156770e-02  1.578667e-02
## lysoPC.a.C17.0_T5 -2.095466e-02 -6.069610e-05  9.744515e-03  2.115434e-02
## lysoPC.a.C18.0_T5 -2.029664e-02 -2.339936e-02  2.503839e-02 -8.690914e-04
## lysoPC.a.C18.1_T5 -2.272586e-02 -2.123719e-02  6.543293e-02  2.017168e-02
## lysoPC.a.C18.2_T5  3.727262e-03 -5.443675e-02  5.953538e-02 -1.388793e-02
## lysoPC.a.C20.3_T5  1.538795e-02 -5.266097e-03  2.515450e-02  2.579262e-02
## lysoPC.a.C20.4_T5 -1.583335e-02  2.995010e-02  4.885155e-02  1.184439e-02
## lysoPC.a.C24.0_T5  5.718407e-04 -2.262104e-03  9.971491e-04 -3.330639e-03
## lysoPC.a.C26.0_T5  2.595772e-03 -1.990860e-03  6.235824e-03  1.827170e-03
## lysoPC.a.C26.1_T5  2.875726e-04 -1.939861e-04  3.612420e-03  5.147405e-03
## lysoPC.a.C28.0_T5 -5.498140e-02  5.707229e-02  2.068614e-02 -8.675595e-02
## lysoPC.a.C28.1_T5  1.555146e-03 -2.611273e-03  3.181606e-03  5.084160e-03
## PC.aa.C24.0_T5    -1.374629e-01  3.899012e-02 -4.679510e-03  4.290627e-02
## PC.aa.C28.1_T5     1.264262e-02  1.651834e-02  4.697052e-03  1.258869e-02
## PC.aa.C30.0_T5     9.509157e-03 -1.084036e-02  8.763277e-03  1.829344e-02
## PC.aa.C32.0_T5     7.060922e-03 -2.078748e-02 -2.678484e-02  3.781383e-02
## PC.aa.C32.1_T5     8.670366e-03 -8.392716e-03 -1.487628e-02  2.512545e-02
## PC.aa.C32.3_T5     2.635003e-03 -2.539982e-03 -1.971844e-03  2.569586e-05
## PC.aa.C34.1_T5    -1.655541e-03 -4.006371e-02  2.923560e-02  1.562440e-02
## PC.aa.C34.2_T5     1.945522e-02 -7.030490e-02  1.741276e-02 -1.957072e-02
## PC.aa.C34.3_T5     2.436174e-02 -7.569831e-03 -1.129910e-02  1.641046e-02
## PC.aa.C34.4_T5     1.111186e-03 -3.123709e-03 -4.724544e-04  4.223478e-03
## PC.aa.C36.0_T5    -2.758176e-03  4.000139e-03  1.463984e-03 -2.471606e-02
## PC.aa.C36.1_T5     6.005389e-02 -3.790845e-02  1.028768e-02 -2.585613e-02
## PC.aa.C36.2_T5     3.122550e-02 -5.583563e-02 -2.128699e-02 -4.580087e-02
## PC.aa.C36.3_T5     3.092294e-02 -4.437962e-02  4.287035e-03  3.552064e-02
## PC.aa.C36.4_T5    -1.712293e-02 -1.462788e-02  2.110505e-02 -5.582300e-03
## PC.aa.C36.5_T5    -6.253055e-02  3.849062e-02  1.659640e-02  5.373327e-02
## PC.aa.C38.0_T5    -6.146516e-03  2.553412e-02  4.828843e-03 -4.908217e-02
## PC.aa.C38.1_T5    -1.419302e-02 -3.219448e-03  4.633061e-03  2.683355e-04
## PC.aa.C38.3_T5     1.126516e-02 -1.494940e-02 -1.676491e-02  1.577700e-02
## PC.aa.C38.4_T5    -3.247244e-02 -1.391018e-02  1.833673e-03  1.766142e-02
## PC.aa.C38.5_T5    -1.466413e-02  3.121508e-02  2.303888e-02  5.831864e-02
## PC.aa.C38.6_T5     6.169770e-03  1.461959e-02  2.817368e-02 -5.650861e-02
## PC.aa.C40.1_T5    -8.137150e-02  3.068700e-02 -4.029423e-02 -6.065788e-02
## PC.aa.C40.2_T5    -3.256298e-03  1.681962e-03  6.628718e-03  1.215998e-03
## PC.aa.C40.3_T5    -2.242938e-03  2.249144e-03  6.600397e-03 -6.786628e-04
## PC.aa.C40.4_T5     8.997859e-04  1.773309e-04  6.020058e-03  8.165618e-03
## PC.aa.C40.5_T5    -1.923452e-03  1.516576e-03  1.482989e-02  3.027891e-02
## PC.aa.C40.6_T5    -1.625425e-02 -5.754693e-04  9.051873e-04 -8.580777e-02
## PC.aa.C42.0_T5    -5.456340e-03  2.653934e-03 -4.780565e-03 -6.800051e-03
## PC.aa.C42.1_T5    -2.667995e-03  1.410918e-03 -1.772976e-03 -5.731648e-04
## PC.aa.C42.2_T5    -1.848809e-03  2.236950e-03  2.196298e-03  1.033593e-03
## PC.aa.C42.4_T5    -1.995113e-03  2.021471e-05  3.012460e-03  1.417566e-03
## PC.aa.C42.5_T5    -2.325950e-03 -5.382566e-05  1.419426e-03  7.269057e-04
## PC.aa.C42.6_T5    -2.188643e-03  1.392983e-03  5.933789e-02  2.240415e-02
## PC.ae.C30.0_T5     1.639049e-02 -3.764746e-03  2.840548e-02  2.381265e-02
## PC.ae.C32.1_T5    -6.331607e-03 -1.020842e-02 -1.966322e-03 -1.619918e-03
## PC.ae.C32.2_T5    -3.291830e-04  2.119178e-04 -3.426393e-03 -4.246982e-03
## PC.ae.C34.0_T5     5.671627e-03 -6.942966e-04 -2.063212e-03  8.925220e-03
## PC.ae.C34.1_T5     8.039200e-03 -1.171585e-02  7.295347e-03  3.691143e-02
## PC.ae.C34.2_T5     1.066536e-03 -2.879997e-02  9.256011e-03  3.257650e-03
## PC.ae.C34.3_T5     2.657153e-03 -6.043150e-02  1.101527e-02 -2.736713e-02
## PC.ae.C36.0_T5     7.395104e-04 -7.802981e-05  2.460101e-03  5.700756e-03
## PC.ae.C36.1_T5    -1.271832e-02  1.896040e-02  2.415752e-02  1.340672e-02
## PC.ae.C36.2_T5     1.485869e-02 -2.667512e-02  6.654433e-03  2.124652e-02
## PC.ae.C36.3_T5     6.701634e-03 -3.444253e-02 -8.827605e-05 -7.646717e-03
## PC.ae.C36.4_T5     1.716565e-02 -8.999339e-03 -7.533279e-03 -1.569510e-02
## PC.ae.C36.5_T5    -2.588521e-02 -1.883164e-02  8.721595e-03 -6.864960e-02
## PC.ae.C38.0_T5    -5.211221e-03  5.543637e-03  4.594996e-03 -2.207065e-03
## PC.ae.C38.2_T5    -1.306292e-02  7.192535e-03  2.210734e-02 -7.937242e-03
## PC.ae.C38.3_T5    -2.048196e-02 -5.795106e-03 -6.004492e-03  2.709467e-02
## PC.ae.C38.4_T5    -1.273895e-02 -1.202732e-02  3.030520e-03  2.812041e-02
## PC.ae.C38.5_T5     3.758560e-03  1.103210e-02 -2.574631e-02 -6.737946e-02
## PC.ae.C38.6_T5     6.310680e-03 -7.039022e-04 -6.450501e-03 -6.197646e-02
## PC.ae.C40.1_T5    -6.764192e-03  4.466229e-03  6.426117e-03 -5.130751e-03
## PC.ae.C40.2_T5    -6.978808e-03  1.528969e-02 -1.656042e-03  1.027703e-02
## PC.ae.C40.3_T5    -2.380573e-02  5.747370e-04 -3.554878e-03  1.564210e-02
## PC.ae.C40.4_T5    -2.403042e-02  1.119413e-02  9.393846e-03  1.470964e-02
## PC.ae.C40.5_T5    -3.285758e-02 -2.736156e-03 -2.279881e-03  4.065757e-03
## PC.ae.C40.6_T5    -1.213788e-02  9.744098e-04  2.325740e-04  1.473291e-03
## PC.ae.C42.1_T5    -2.808287e-03 -6.335323e-04  3.211426e-03  3.844859e-03
## PC.ae.C42.2_T5    -1.681200e-03 -1.837986e-03  3.116783e-03  6.392945e-03
## PC.ae.C42.3_T5    -4.762189e-03 -4.494899e-04  6.350234e-03  7.672825e-04
## PC.ae.C42.4_T5    -6.943363e-03 -1.624303e-04  3.564018e-03  5.257609e-03
## PC.ae.C42.5_T5    -4.122986e-02  2.159659e-03 -7.417321e-03  3.205233e-03
## PC.ae.C44.3_T5     1.001661e-03  3.166641e-04  8.738107e-04  1.637305e-03
## PC.ae.C44.4_T5    -3.080457e-04 -3.728130e-03 -1.048451e-03  5.468005e-03
## PC.ae.C44.5_T5    -2.629455e-02  4.645727e-03 -1.307019e-02 -8.843564e-03
## PC.ae.C44.6_T5    -1.927815e-02  9.183061e-03 -1.390156e-02 -9.158867e-03
## SM..OH..C14.1_T5   2.329571e-02  1.113566e-02 -1.288062e-02  1.854883e-02
## SM..OH..C16.1_T5   1.015557e-02  1.339242e-03 -3.242055e-03  1.838197e-02
## SM..OH..C22.1_T5   9.607288e-03 -3.074351e-02  2.668303e-02  9.173650e-04
## SM..OH..C22.2_T5   9.790622e-03 -2.825564e-02  1.869615e-02 -5.797061e-03
## SM..OH..C24.1_T5   3.649786e-03 -4.087345e-03  3.821284e-03  5.793181e-03
## SM.C16.0_T5        9.185154e-03 -1.115769e-02  1.773023e-02  5.532379e-03
## SM.C16.1_T5        9.166894e-02 -2.743497e-02  9.657495e-04 -5.794306e-02
## SM.C18.0_T5        6.963746e-02 -2.260284e-02 -3.155269e-02  4.799775e-02
## SM.C18.1_T5        8.156588e-02 -3.190616e-02 -3.437912e-02 -4.845540e-02
## SM.C20.2_T5        4.267424e-03 -3.564258e-03  2.697093e-04  3.545918e-03
## SM.C24.0_T5       -1.683201e-02 -3.826769e-02  6.505490e-02 -1.778616e-02
## SM.C24.1_T5       -3.016514e-02 -3.450708e-02  2.368949e-02  3.171158e-02
##                            PC37          PC38          PC39
## GLU_T0             2.117568e-03 -2.521041e-02  1.188556e-02
## INS_T0             4.735738e-02  5.755430e-02  3.592134e-02
## HOMA_T0            3.730470e-02  2.761675e-02 -1.589256e-02
## HBA1C_T0          -1.202209e-02 -1.218748e-02  6.074584e-02
## HBA1C.mmol.mol_T0 -4.274389e-02 -4.418981e-02 -3.919113e-02
## PESO_T0            3.539852e-02 -1.092509e-02  1.237722e-03
## bmi_T0             3.112865e-02  3.099812e-02 -6.598075e-02
## CC_T0              2.029228e-03 -2.695357e-03 -7.212352e-02
## CINT_T0            3.978062e-02  2.895238e-02  5.912401e-02
## CAD_T0             2.686217e-02  5.245300e-02 -4.644209e-02
## TAD_T0            -9.794284e-02  5.137471e-02  2.597234e-02
## TAS_T0            -9.729626e-02  6.761506e-02 -9.247554e-02
## TG_T0              3.590398e-02 -1.726802e-03  5.298343e-02
## COL_T0             9.748518e-03  7.010446e-02  4.326379e-02
## LDL_T0             5.916170e-02  7.519742e-02 -4.162080e-03
## HDL_T0            -1.289324e-01 -6.585384e-02  1.423096e-01
## VLDL_T0            3.648229e-02 -2.061246e-03 -9.780679e-03
## PCR_T0             5.733303e-02  1.065152e-01 -5.839563e-02
## LEP_T0            -6.585011e-02 -6.758918e-02 -2.724369e-02
## ADIPO_T0          -2.218169e-02  7.115386e-02  1.725535e-03
## GOT_T0             1.259204e-01 -9.916690e-02 -3.365524e-02
## GPT_T0             1.323132e-01 -1.087630e-01  6.391437e-02
## GGT_T0             3.497811e-02 -3.110783e-02  4.862459e-03
## URICO_T0           7.976503e-02 -2.342045e-02  9.893430e-02
## CREAT_T0           1.573650e-02 -5.510170e-03 -6.715642e-02
## UREA_T0           -9.660382e-02 -4.878547e-03 -6.843538e-02
## HIERRO_T0         -6.993569e-02  1.047185e-01  8.234527e-03
## TRANSF_T0         -5.151651e-02  3.088880e-02  2.227588e-02
## FERR_T0            4.918000e-02  2.243439e-03  1.690832e-02
## Ile_T0            -5.665520e-02 -3.847636e-03  3.702383e-02
## Leu_T0            -2.855698e-02  2.860293e-02  2.402649e-02
## Val_T0            -6.859296e-02  3.747386e-02 -1.315716e-02
## Ala_T0            -3.605949e-02  2.089455e-02  2.584557e-02
## Pro_T0            -1.259067e-02  8.885843e-02  4.479633e-03
## Gly_T0            -1.276684e-02  5.721028e-02 -2.470784e-02
## Ser_T0            -6.756119e-02  4.197696e-02 -3.156729e-02
## Trp_T0             1.063681e-01 -3.594951e-02 -1.116742e-01
## Phe_T0             6.915327e-02  5.799658e-02  1.500370e-02
## Met_T0             1.819382e-02 -6.126613e-03 -9.729197e-03
## Orn_T0            -4.678186e-02  5.323088e-02  4.304997e-03
## Arg_T0            -4.916214e-02  7.919409e-03 -2.783388e-03
## His_T0            -2.421091e-04  2.062609e-02  9.193333e-03
## Asn_T0             3.476578e-02 -6.595617e-02 -1.765577e-03
## Asp_T0             4.603383e-03 -2.789566e-02  4.835413e-03
## Glu_T0            -1.325426e-02 -2.806577e-03 -5.054135e-05
## Gln_T0            -6.081824e-02  4.119007e-02  5.244894e-03
## Cit_T0             8.296081e-02  8.214910e-04 -4.194319e-03
## Tyr_T0            -4.770406e-03  5.084074e-02  1.857719e-02
## Thr_T0            -8.384575e-03 -3.798469e-02  6.323290e-03
## Lys_T0            -2.094840e-02 -2.341168e-02 -3.943616e-03
## Creatinine_T0      1.059260e-01 -6.953307e-02 -1.704559e-02
## Kynurenine_T0      6.891407e-03  6.412697e-02  5.492529e-02
## Putrescine_T0      1.601549e-02 -9.895975e-02 -1.732720e-02
## Sarcosine_T0       2.976800e-02 -1.190703e-01 -3.421078e-02
## Serotonin_T0       1.492662e-02  6.680367e-02  2.224684e-02
## Taurine_T0         6.044062e-02 -6.615121e-03  1.291062e-02
## SDMA_T0            5.632207e-03  1.703686e-03 -3.500861e-02
## C0_T0              4.261089e-02 -6.154687e-02  8.243574e-03
## C2_T0              1.055701e-01  6.564921e-02  2.025772e-02
## C3.OH_T0           5.986354e-04  1.433784e-03  1.306474e-02
## C6..C4.1.DC._T0    1.981837e-02  1.635077e-02  2.055384e-03
## C5.DC..C6.OH._T0   1.286246e-01  5.677075e-02  5.562933e-03
## C7.DC_T0          -1.218531e-01 -1.187377e-01  2.954656e-03
## C8_T0              3.679502e-03  6.842985e-03 -6.464603e-02
## C10_T0            -3.015875e-03  2.678919e-03 -2.560235e-04
## C10.1_T0          -2.147728e-05  2.603568e-03  3.250285e-02
## C10.2_T0          -8.597385e-04 -6.447458e-04 -5.370984e-02
## C14.1_T0           1.640237e-04  3.069930e-04  1.407527e-03
## C14.2_T0           7.321855e-04 -1.723548e-04  5.500712e-02
## C16.1_T0          -1.973569e-04 -1.600472e-03  7.641816e-03
## C16.2_T0           1.089810e-03 -1.636806e-03 -3.070995e-02
## C16.2.OH_T0        7.361522e-04 -1.136436e-03  1.286728e-02
## C18.1_T0           4.878185e-03 -9.030452e-04 -7.732176e-02
## C18.1.OH_T0        1.305695e-03 -1.113823e-03  1.817323e-03
## C18.2_T0           1.517477e-03 -2.168426e-04  6.837206e-02
## lysoPC.a.C16.0_T0  5.925479e-02 -2.323813e-02 -7.086826e-03
## lysoPC.a.C16.1_T0  1.509978e-03 -3.239819e-03 -1.722575e-02
## lysoPC.a.C17.0_T0  8.973994e-03  5.384810e-03  2.803392e-02
## lysoPC.a.C18.0_T0  3.706186e-02 -1.898802e-02  1.464091e-02
## lysoPC.a.C18.1_T0  8.814201e-02 -3.374443e-02  1.153001e-02
## lysoPC.a.C18.2_T0  9.539700e-03 -8.678938e-02  3.232488e-04
## lysoPC.a.C20.3_T0  5.478471e-02  6.289970e-02  6.347960e-02
## lysoPC.a.C20.4_T0  8.204136e-02 -6.089857e-03  1.436889e-02
## lysoPC.a.C24.0_T0 -4.935401e-05 -3.591564e-04  2.601754e-02
## lysoPC.a.C26.0_T0  6.561480e-02 -3.271140e-03  2.421962e-02
## lysoPC.a.C26.1_T0 -1.187051e-02 -3.347539e-03  3.322706e-02
## lysoPC.a.C28.0_T0  9.106006e-03  6.883127e-02 -3.886552e-02
## lysoPC.a.C28.1_T0 -6.673127e-03 -7.640753e-03 -8.165740e-03
## PC.aa.C24.0_T0    -1.097816e-01  8.300824e-02 -2.743200e-02
## PC.aa.C28.1_T0    -1.216964e-02 -1.994863e-02  3.889700e-02
## PC.aa.C30.0_T0     1.339372e-02 -2.561169e-03  5.177903e-02
## PC.aa.C32.0_T0     3.847240e-02  1.782135e-02 -5.157388e-02
## PC.aa.C32.1_T0     3.356918e-02 -1.472330e-02 -4.457246e-04
## PC.aa.C32.3_T0    -2.615994e-03  3.783848e-05 -5.726431e-02
## PC.aa.C34.1_T0     7.273197e-02 -6.059101e-02  1.051268e-03
## PC.aa.C34.2_T0     2.404871e-02 -4.242063e-02 -2.453367e-02
## PC.aa.C34.3_T0    -3.286924e-02 -4.395346e-02  9.134192e-03
## PC.aa.C34.4_T0    -3.461794e-03 -1.009486e-02  1.154565e-02
## PC.aa.C36.0_T0    -2.068842e-02 -1.142615e-02 -3.900238e-02
## PC.aa.C36.1_T0     3.755563e-02 -3.724335e-03  4.302759e-04
## PC.aa.C36.2_T0    -5.722536e-02 -9.240582e-02 -7.058518e-03
## PC.aa.C36.3_T0     9.451291e-03  7.462151e-02 -1.319554e-03
## PC.aa.C36.4_T0    -2.215336e-02 -1.034448e-02 -3.266063e-03
## PC.aa.C36.5_T0    -5.946546e-02 -4.020780e-02 -1.225698e-02
## PC.aa.C38.0_T0    -7.878786e-03  1.893714e-02 -1.745074e-02
## PC.aa.C38.1_T0    -3.444389e-02 -2.722567e-02 -6.153721e-02
## PC.aa.C38.3_T0    -1.647406e-03  8.804287e-02  4.788482e-03
## PC.aa.C38.4_T0    -3.785578e-02  1.395713e-02  1.466887e-03
## PC.aa.C38.5_T0    -5.291211e-02 -6.284827e-02  9.780684e-03
## PC.aa.C38.6_T0    -6.168039e-03 -4.067656e-02 -1.068625e-02
## PC.aa.C40.1_T0     3.577010e-03 -3.384130e-02 -4.386854e-02
## PC.aa.C40.2_T0    -2.629475e-03  1.237590e-03  4.113296e-02
## PC.aa.C40.3_T0    -3.463164e-03  6.695665e-03 -4.002757e-02
## PC.aa.C40.4_T0    -1.772288e-02  5.816073e-03 -6.371919e-02
## PC.aa.C40.5_T0    -3.779104e-02 -2.662079e-02  7.157684e-03
## PC.aa.C40.6_T0     1.732900e-02  5.787835e-03 -9.874514e-03
## PC.aa.C42.0_T0    -1.320910e-03  4.383329e-03 -2.555865e-02
## PC.aa.C42.1_T0    -1.085484e-03 -2.229339e-03 -3.160766e-02
## PC.aa.C42.2_T0     7.101416e-04 -3.054815e-03 -6.288097e-02
## PC.aa.C42.4_T0    -2.311571e-03  3.919037e-04 -1.670791e-02
## PC.aa.C42.5_T0     2.356003e-04 -1.754804e-03  1.602198e-02
## PC.aa.C42.6_T0     1.716956e-01 -3.695328e-03 -5.587172e-03
## PC.ae.C30.0_T0     3.716023e-03 -3.253904e-03 -3.162962e-02
## PC.ae.C32.1_T0     9.050604e-03  1.161370e-03  3.852873e-02
## PC.ae.C32.2_T0    -2.336676e-03 -1.013142e-03  1.426887e-02
## PC.ae.C34.0_T0     7.061533e-03  2.813911e-03 -4.504068e-02
## PC.ae.C34.1_T0     3.850006e-02 -1.271808e-02 -3.097239e-02
## PC.ae.C34.2_T0    -5.391320e-03 -3.329775e-02  2.285789e-02
## PC.ae.C34.3_T0    -4.600721e-02 -6.073001e-02 -2.696889e-02
## PC.ae.C36.0_T0     9.182838e-03 -4.672445e-03  7.306422e-02
## PC.ae.C36.1_T0    -4.298484e-03  1.774548e-03  2.773847e-02
## PC.ae.C36.2_T0    -2.912022e-02 -1.508869e-02 -3.357649e-02
## PC.ae.C36.3_T0    -2.393613e-02  4.406421e-03  4.579653e-02
## PC.ae.C36.4_T0    -2.828252e-02 -7.294735e-02  1.364791e-02
## PC.ae.C36.5_T0    -3.705620e-02 -6.590852e-02 -3.439365e-02
## PC.ae.C38.0_T0    -5.308652e-03 -9.878335e-03  5.384931e-02
## PC.ae.C38.2_T0    -1.081784e-02  1.712723e-03  3.035704e-02
## PC.ae.C38.3_T0    -3.702372e-03  1.308539e-02  4.319602e-03
## PC.ae.C38.4_T0    -1.975884e-02  2.066726e-02  3.521426e-02
## PC.ae.C38.5_T0     4.012896e-03  1.220470e-02  1.746218e-02
## PC.ae.C38.6_T0    -2.287658e-02 -1.326490e-02 -7.524696e-02
## PC.ae.C40.1_T0    -1.079452e-03 -1.257403e-02 -5.175535e-02
## PC.ae.C40.2_T0    -4.167037e-03  6.366996e-03  6.252359e-03
## PC.ae.C40.3_T0    -8.524891e-03  8.644925e-03 -5.459263e-03
## PC.ae.C40.4_T0     7.366403e-04  1.336838e-03  3.886927e-02
## PC.ae.C40.5_T0    -2.481760e-03  1.802017e-02  5.414655e-02
## PC.ae.C40.6_T0    -1.301931e-02  1.603256e-02 -7.367653e-02
## PC.ae.C42.1_T0    -6.175366e-03 -7.021138e-04 -6.542200e-02
## PC.ae.C42.2_T0     7.939073e-04 -1.288031e-03  4.501267e-02
## PC.ae.C42.3_T0    -2.101872e-03 -5.563096e-03  6.188597e-02
## PC.ae.C42.4_T0    -1.086860e-02  1.395128e-03 -6.041033e-02
## PC.ae.C42.5_T0    -1.746493e-03  2.051658e-02 -2.151526e-02
## PC.ae.C44.3_T0    -2.235193e-03 -9.606515e-04  5.805768e-02
## PC.ae.C44.4_T0     2.435699e-03  6.610200e-04 -3.489276e-02
## PC.ae.C44.5_T0     2.196388e-02  3.565254e-02  1.974218e-02
## PC.ae.C44.6_T0    -7.199350e-03  1.654272e-02 -5.522298e-02
## SM..OH..C14.1_T0   2.613352e-02 -2.225322e-02  6.186348e-02
## SM..OH..C16.1_T0   1.028467e-02 -6.051118e-04  2.270264e-02
## SM..OH..C22.1_T0  -1.935843e-02  1.601693e-02 -6.439420e-02
## SM..OH..C22.2_T0   2.130361e-02 -2.950720e-02 -1.476653e-02
## SM..OH..C24.1_T0  -1.617207e-03 -2.862300e-03 -1.290743e-02
## SM.C16.0_T0       -4.935923e-02  3.928988e-02  1.150297e-02
## SM.C16.1_T0       -1.056024e-02 -1.756543e-02  2.789298e-02
## SM.C18.0_T0       -2.919638e-02 -1.507887e-02  3.025550e-02
## SM.C18.1_T0       -1.467773e-02 -5.153687e-02  2.568638e-02
## SM.C20.2_T0        2.869002e-03 -1.685010e-04  7.745966e-02
## SM.C24.0_T0       -2.526073e-02  2.612788e-02 -4.224493e-02
## SM.C24.1_T0       -1.565848e-02  4.674694e-02 -4.357387e-03
## MEDDM_T2           1.727047e-03 -1.841151e-03  5.588307e-02
## MEDCOL_T2          1.727047e-03 -1.841151e-03  5.588307e-02
## MEDINF_T2         -2.176326e-02 -3.830507e-03 -5.284287e-02
## MEDHTA_T2         -1.326789e-02 -3.765270e-03 -4.552373e-02
## GLU_T2            -1.702276e-02 -6.819998e-03 -1.710042e-03
## INS_T2            -1.303917e-01 -2.922503e-02  2.150953e-02
## HOMA_T2           -6.321133e-02 -2.174876e-02 -1.722385e-03
## HBA1C_T2          -1.586130e-02 -2.163517e-02  8.898172e-04
## HBA1C.mmol.mol_T2 -7.162768e-02 -9.539172e-02 -3.290016e-03
## PESO_T2            1.206454e-02 -2.455943e-02 -1.989579e-02
## bmi_T2             7.209663e-03  2.060288e-02  5.070781e-03
## CC_T2              5.355984e-03 -8.068842e-03  4.893326e-02
## CINT_T2            4.104565e-02 -7.716923e-02 -1.523020e-02
## CAD_T2            -1.972592e-02  1.848454e-02  4.275064e-03
## TAD_T2             1.088555e-01 -2.944152e-02 -1.432875e-02
## TAS_T2             7.368593e-02  6.759732e-02 -1.624227e-02
## TG_T2              1.892871e-01 -3.027067e-02 -7.251392e-03
## COL_T2             3.854468e-02  2.546393e-02  5.251871e-03
## LDL_T2             2.913013e-02 -9.520871e-03 -8.599329e-03
## HDL_T2            -9.008435e-03  1.082523e-01  5.690609e-04
## VLDL_T2           -2.268370e-03  7.069026e-03  2.517383e-03
## PCR_T2            -7.241760e-02  9.241763e-03 -3.998204e-02
## LEP_T2            -1.856766e-02  4.635220e-02  1.435715e-02
## ADIPO_T2          -3.405759e-02  1.502118e-02 -5.722906e-02
## GOT_T2            -4.537244e-02  7.891785e-02 -9.798520e-03
## GPT_T2             2.267625e-02  9.915561e-02 -1.686946e-02
## GGT_T2             6.597258e-02  3.079343e-03  4.608398e-04
## URICO_T2           5.875860e-04  5.242098e-02  4.970257e-02
## CREAT_T2           2.589429e-02 -1.293669e-03  6.028493e-02
## UREA_T2           -2.287124e-02 -5.922424e-02 -3.088712e-03
## HIERRO_T2         -1.499520e-01  1.203048e-02 -1.033211e-02
## TRANSF_T2         -4.230566e-03  7.421124e-02  5.239191e-03
## FERR_T2           -1.052530e-01 -5.425341e-02  1.055970e-02
## Ile_T2            -3.219563e-02  6.030086e-02  3.564639e-03
## Leu_T2            -4.583057e-02  1.089027e-01 -5.822811e-03
## Val_T2            -2.366135e-02  9.495871e-02  5.597699e-03
## Ala_T2             9.739590e-03 -3.804099e-02  2.718231e-04
## Pro_T2             1.151864e-02  5.044763e-02  1.532805e-03
## Gly_T2             5.850771e-02  5.090638e-02 -1.088078e-02
## Ser_T2            -1.104827e-01 -6.799471e-02 -1.896526e-03
## Trp_T2             2.855863e-02  9.707229e-03  1.480887e-04
## Phe_T2            -3.982923e-02 -1.903528e-02 -5.924679e-03
## Met_T2             4.976932e-02  2.071089e-02  4.600484e-03
## Orn_T2             4.238182e-03  1.155833e-01  5.493727e-03
## Arg_T2            -5.261855e-02 -8.238660e-02 -2.501668e-02
## His_T2            -2.110801e-02  1.091054e-01 -2.388076e-03
## Asn_T2            -4.886323e-02 -2.891011e-02 -3.525920e-03
## Asp_T2            -5.744949e-02 -5.385716e-04  2.473827e-03
## Glu_T2            -3.755762e-02 -2.057565e-02  1.525296e-02
## Gln_T2             7.848087e-04 -9.487935e-02  8.002747e-03
## Cit_T2             1.081399e-01 -1.650974e-02  1.717362e-03
## Tyr_T2            -1.416134e-02 -4.207483e-02  2.108622e-03
## Thr_T2            -4.209889e-03  5.161762e-02 -7.123486e-03
## Lys_T2            -9.709277e-03  3.470195e-02 -1.026858e-02
## Creatinine_T2      1.037285e-01 -7.119747e-02 -7.315987e-03
## Kynurenine_T2     -1.150693e-02  3.233985e-02 -5.422998e-02
## Putrescine_T2     -1.593938e-02 -7.879843e-02  4.708489e-03
## Sarcosine_T2       8.057070e-02 -7.749958e-02 -3.364467e-02
## Serotonin_T2       5.707764e-02 -1.849802e-02 -2.544118e-02
## Taurine_T2         2.171340e-02  8.307754e-04  1.837967e-02
## SDMA_T2            2.114782e-02  4.684009e-04 -3.067325e-02
## C0_T2             -1.310058e-02 -7.692354e-02  5.802730e-03
## C2_T2              3.723289e-02  9.101173e-02 -2.261781e-02
## C3.OH_T2          -3.452144e-03 -1.557019e-03  4.676120e-02
## C6..C4.1.DC._T2    1.995521e-02 -1.349176e-01  9.291476e-04
## C5.DC..C6.OH._T2   5.752213e-02  2.270151e-02 -7.948905e-03
## C7.DC_T2           9.875934e-02  5.825032e-02  3.622388e-02
## C8_T2             -1.039434e-02 -8.291192e-03  7.850238e-02
## C10_T2            -8.599983e-03 -1.280944e-02  7.259299e-02
## C10.1_T2          -3.532661e-04 -2.172061e-03 -5.073352e-02
## C10.2_T2          -5.327587e-04 -3.737213e-03 -3.451799e-02
## C14.1_T2          -1.824881e-03 -2.581232e-03  3.572699e-02
## C14.2_T2           7.702311e-04 -6.402643e-04 -1.980219e-02
## C16.1_T2          -1.240068e-04 -2.992925e-03 -4.424140e-02
## C16.2_T2           9.781930e-04 -2.903796e-03  4.588878e-02
## C16.2.OH_T2        1.839353e-03 -2.686897e-03 -6.706899e-02
## C18.1_T2           2.812620e-03 -2.407605e-03  4.485224e-04
## C18.1.OH_T2        6.939188e-04 -8.376824e-04  5.140138e-02
## C18.2_T2           1.148901e-03 -2.671858e-03 -5.285828e-03
## lysoPC.a.C14.0_T2 -2.647628e-02  1.024919e-01  3.246854e-02
## lysoPC.a.C16.0_T2  2.817785e-02  2.346681e-02  4.874171e-03
## lysoPC.a.C16.1_T2 -1.035376e-02  3.627476e-02  9.619556e-03
## lysoPC.a.C17.0_T2  1.941928e-02  1.619759e-02 -8.633109e-02
## lysoPC.a.C18.0_T2 -3.732822e-03  5.266436e-03  4.245790e-03
## lysoPC.a.C18.1_T2  6.983115e-03  2.584835e-02  6.756472e-03
## lysoPC.a.C18.2_T2  1.989842e-02  2.253930e-02 -1.038181e-03
## lysoPC.a.C20.3_T2 -3.229930e-02  4.295242e-03 -7.805769e-02
## lysoPC.a.C20.4_T2 -1.660033e-02  4.693672e-02 -2.013690e-02
## lysoPC.a.C24.0_T2 -5.301523e-03 -9.899592e-03  5.177497e-02
## lysoPC.a.C26.0_T2  4.387996e-02 -2.259834e-02  3.849744e-02
## lysoPC.a.C26.1_T2 -1.058859e-02 -1.151435e-02  7.659622e-02
## lysoPC.a.C28.0_T2 -1.401613e-02  1.166300e-01  4.270553e-04
## lysoPC.a.C28.1_T2 -4.376575e-03 -5.651963e-03 -7.337138e-02
## PC.aa.C24.0_T2     4.746064e-02 -1.340958e-01  8.989778e-03
## PC.aa.C28.1_T2     1.730855e-03  1.453062e-02 -2.003571e-02
## PC.aa.C30.0_T2    -1.267358e-02  6.077773e-03  6.599823e-02
## PC.aa.C32.0_T2    -1.227860e-02  1.204394e-02 -1.980014e-02
## PC.aa.C32.1_T2    -4.969026e-02  8.158186e-03 -4.479777e-03
## PC.aa.C32.3_T2     1.226557e-03  3.394883e-04 -2.018918e-02
## PC.aa.C34.1_T2     2.195739e-02 -1.058371e-01  6.322882e-04
## PC.aa.C34.2_T2     3.138937e-02 -7.369280e-02 -5.698837e-03
## PC.aa.C34.3_T2     5.161049e-06 -2.560154e-02 -2.555899e-02
## PC.aa.C34.4_T2     1.606635e-04  1.816655e-03  4.515618e-02
## PC.aa.C36.0_T2    -6.701135e-03 -1.226948e-02 -4.084672e-02
## PC.aa.C36.1_T2    -1.130983e-02 -4.699136e-02 -1.791836e-02
## PC.aa.C36.2_T2     3.546241e-02 -1.035247e-01  3.665310e-03
## PC.aa.C36.3_T2     1.798845e-03 -9.057602e-04  7.940384e-03
## PC.aa.C36.4_T2    -1.189059e-02  7.964878e-02 -1.265546e-02
## PC.aa.C36.5_T2     4.502116e-02  2.123708e-02  1.521398e-02
## PC.aa.C38.0_T2    -8.571626e-03 -3.534871e-03  4.417925e-02
## PC.aa.C38.1_T2    -2.015076e-03 -3.588653e-02 -3.932565e-02
## PC.aa.C38.3_T2    -4.993500e-02 -1.490546e-02 -1.249396e-03
## PC.aa.C38.4_T2    -2.590494e-02  6.308856e-02  5.387572e-03
## PC.aa.C38.5_T2    -2.064996e-02  2.811827e-02 -1.844700e-02
## PC.aa.C38.6_T2     1.727803e-02 -2.955702e-02 -1.957358e-02
## PC.aa.C40.1_T2    -8.562184e-02 -3.962671e-02 -3.555017e-02
## PC.aa.C40.2_T2    -1.171387e-02 -7.428720e-03  7.568071e-02
## PC.aa.C40.3_T2    -1.821950e-02 -6.136713e-03  6.545997e-02
## PC.aa.C40.4_T2    -4.317749e-02 -6.844827e-03 -6.031256e-02
## PC.aa.C40.5_T2    -2.755114e-02 -2.115073e-02 -3.325989e-02
## PC.aa.C40.6_T2     1.322567e-02 -2.702702e-02 -7.136506e-03
## PC.aa.C42.0_T2    -6.635591e-03 -5.009915e-03  7.144013e-02
## PC.aa.C42.1_T2    -4.064263e-03 -3.019624e-03  4.380213e-02
## PC.aa.C42.2_T2    -4.581931e-03 -2.731589e-03 -2.056679e-02
## PC.aa.C42.4_T2    -4.729283e-03 -2.450667e-03  6.637156e-02
## PC.aa.C42.5_T2    -3.058318e-03 -1.932134e-03 -6.764001e-02
## PC.aa.C42.6_T2     9.721978e-02  1.748502e-02 -4.278162e-02
## PC.ae.C30.0_T2     2.194231e-02 -4.091060e-02 -4.827815e-02
## PC.ae.C32.1_T2     9.492724e-03 -1.189321e-02  5.961662e-02
## PC.ae.C32.2_T2     7.885851e-04  3.516164e-03 -3.020032e-02
## PC.ae.C34.0_T2     3.202054e-03 -8.624313e-04  7.373969e-02
## PC.ae.C34.1_T2     2.349103e-02  8.698817e-04 -3.874838e-02
## PC.ae.C34.2_T2     3.435687e-03 -5.340939e-02  3.191004e-02
## PC.ae.C34.3_T2     6.389125e-03 -2.492512e-02 -1.043066e-03
## PC.ae.C36.0_T2     1.258673e-03 -1.230275e-03 -6.859033e-02
## PC.ae.C36.1_T2    -2.476374e-02 -1.273553e-02 -5.882298e-02
## PC.ae.C36.2_T2     2.744198e-02 -4.610516e-03  3.052909e-02
## PC.ae.C36.3_T2    -9.219721e-03 -1.224979e-02 -7.285703e-02
## PC.ae.C36.4_T2    -1.030255e-02 -3.676974e-03 -1.700705e-02
## PC.ae.C36.5_T2    -9.716728e-04  1.608204e-02  4.298450e-02
## PC.ae.C38.0_T2     4.557854e-03  4.822692e-03  3.055495e-02
## PC.ae.C38.2_T2    -2.270883e-02 -1.671835e-02  4.339225e-02
## PC.ae.C38.3_T2    -4.194058e-02 -1.818879e-03  2.162365e-02
## PC.ae.C38.4_T2    -1.852100e-02 -3.937558e-03  2.499104e-02
## PC.ae.C38.5_T2    -1.271872e-02  4.574518e-02  1.570241e-02
## PC.ae.C38.6_T2    -2.393509e-03 -3.867801e-03  6.281870e-02
## PC.ae.C40.1_T2    -9.441027e-03  5.623426e-04  3.741672e-02
## PC.ae.C40.2_T2     1.248168e-03  7.854576e-03 -1.681343e-03
## PC.ae.C40.3_T2    -3.007910e-02 -1.364593e-02  5.940931e-02
## PC.ae.C40.4_T2    -2.032547e-02 -8.558034e-03 -6.715043e-02
## PC.ae.C40.5_T2    -2.500938e-02 -9.480185e-03  2.630184e-02
## PC.ae.C40.6_T2     9.056461e-03 -4.348990e-03  4.889974e-02
## PC.ae.C42.1_T2    -8.996672e-03  9.354325e-04  3.430023e-02
## PC.ae.C42.2_T2    -5.717372e-03 -5.771262e-03  1.812621e-02
## PC.ae.C42.3_T2    -3.194656e-03 -3.787553e-05 -6.742196e-02
## PC.ae.C42.4_T2    -5.676582e-03 -1.066225e-02  1.352830e-02
## PC.ae.C42.5_T2    -1.633710e-02 -1.151189e-02  1.034898e-02
## PC.ae.C44.3_T2    -2.378579e-02 -4.125315e-03  5.509272e-02
## PC.ae.C44.4_T2    -3.568277e-05 -7.554961e-03  1.608434e-02
## PC.ae.C44.5_T2     1.343282e-02  7.668739e-03 -1.671505e-02
## PC.ae.C44.6_T2    -7.658264e-06 -1.787181e-03  3.142630e-02
## SM..OH..C14.1_T2   1.445243e-02  3.236652e-03 -3.312035e-02
## SM..OH..C16.1_T2   3.365645e-03  4.237589e-03 -7.235356e-02
## SM..OH..C22.1_T2   5.482839e-03 -3.315232e-02  3.322581e-03
## SM..OH..C22.2_T2   2.837897e-02 -7.525910e-03 -1.591190e-02
## SM..OH..C24.1_T2   1.460332e-03 -4.834443e-03 -5.393775e-02
## SM.C16.0_T2       -6.032987e-02 -8.018584e-02  8.611628e-03
## SM.C16.1_T2        4.293658e-03 -2.687482e-02 -1.165035e-02
## SM.C18.0_T2       -5.275215e-02  3.266988e-02 -3.587488e-02
## SM.C18.1_T2        2.131152e-02  2.143218e-02  4.293345e-02
## SM.C20.2_T2        9.469069e-04 -8.112077e-04  7.247939e-02
## SM.C24.0_T2       -5.331266e-02 -6.183288e-02 -5.288761e-02
## SM.C24.1_T2       -2.060196e-02 -5.659446e-02 -6.190337e-03
## MEDDM_T4           3.541201e-03 -7.548380e-03  5.220239e-02
## MEDCOL_T4         -1.860532e-02  4.673959e-03 -9.355955e-02
## MEDINF_T4         -2.068164e-02 -5.221715e-04  3.083247e-02
## MEDHTA_T4         -1.225068e-02  1.448771e-02  8.627476e-03
## GLU_T4            -1.863282e-02  1.228925e-02 -4.454295e-03
## INS_T4            -1.071371e-01  1.272969e-01 -3.324858e-02
## HOMA_T4           -3.336362e-02  3.964981e-02 -2.398558e-02
## HBA1C_T4          -1.104605e-02 -1.348865e-02  8.296842e-02
## HBA1C.mmol.mol_T4 -4.626263e-02 -5.563341e-02 -3.783545e-04
## PESO_T4            3.533363e-02 -1.512258e-02 -8.297972e-03
## bmi_T4             3.098577e-02  3.071008e-02 -7.695899e-04
## CC_T4              5.776426e-04 -4.679184e-05  6.441805e-02
## CINT_T4            1.800351e-03 -5.544338e-02 -2.455013e-05
## CAD_T4            -1.600823e-02  1.474144e-03  1.153800e-02
## TAD_T4            -1.703987e-02  8.092855e-02  4.271181e-03
## TAS_T4             4.910076e-02  1.993989e-02  2.685433e-03
## TG_T4              8.167765e-03  1.227116e-02 -6.398831e-03
## COL_T4             4.513533e-02  3.798645e-03 -1.960690e-03
## LDL_T4             5.884380e-02  4.036369e-02  1.287144e-02
## HDL_T4             1.427129e-02 -8.743709e-02  6.176977e-03
## VLDL_T4            2.658765e-02 -5.384980e-02 -2.849029e-03
## PCR_T4            -5.558094e-02  8.473924e-02  5.638109e-02
## LEP_T4            -6.790747e-02  7.964019e-02  3.888201e-03
## ADIPO_T4           5.080642e-02  6.030809e-02 -3.658212e-02
## GOT_T4             3.338537e-02 -3.755571e-02 -5.796492e-04
## GPT_T4             2.536972e-02  1.097926e-01 -1.288439e-02
## GGT_T4            -5.799580e-02  6.377419e-02 -8.853067e-03
## URICO_T4           5.049829e-02 -2.761375e-03 -7.712959e-02
## CREAT_T4           1.698526e-02 -8.069392e-03  8.323277e-02
## UREA_T4            5.623567e-02 -8.984320e-03 -8.188091e-03
## HIERRO_T4          3.748530e-02 -3.841517e-02  2.996718e-03
## TRANSF_T4          4.274531e-02 -6.259713e-02  2.604370e-02
## FERR_T4           -2.479804e-02  1.005537e-02  1.687305e-02
## Ile_T4            -4.936390e-02 -3.575053e-02  6.796585e-03
## Leu_T4            -2.644718e-02  9.943449e-03  1.819621e-02
## Val_T4            -9.890216e-04  2.520751e-03  8.585385e-03
## Ala_T4            -5.500822e-02 -4.890537e-02 -5.497377e-03
## Pro_T4             5.079687e-02  4.990576e-02  1.847718e-02
## Gly_T4             8.057911e-02 -1.508693e-02  4.261088e-03
## Ser_T4             2.312225e-02 -3.726208e-02 -1.167936e-02
## Trp_T4             6.088201e-02 -2.332481e-02  1.925184e-03
## Phe_T4             1.020903e-02  3.294650e-02 -9.790934e-03
## Met_T4             1.827218e-02  5.153875e-03 -1.381989e-02
## Orn_T4             7.407911e-02  7.061721e-02  3.301975e-03
## Arg_T4            -3.254947e-02 -2.405612e-02 -8.754819e-03
## His_T4             1.858451e-02  8.532966e-03 -1.053812e-03
## Asn_T4             1.567921e-02 -3.704667e-02 -2.724477e-03
## Asp_T4             1.795619e-01 -6.283104e-02  3.010575e-03
## Glu_T4            -3.730497e-02  1.876912e-02  4.904714e-03
## Gln_T4             4.200471e-02  3.432836e-02 -3.113812e-04
## Cit_T4             7.553356e-02  5.891736e-03  1.976573e-03
## Tyr_T4             3.433599e-02  2.658149e-02  9.625836e-03
## Thr_T4             7.262812e-02 -7.527740e-02  1.174837e-02
## Lys_T4             2.165776e-02  1.695061e-02 -2.768542e-02
## Creatinine_T4     -2.779948e-03 -4.922814e-02 -6.823370e-03
## Kynurenine_T4      1.721296e-02 -1.172129e-01 -2.066939e-02
## Putrescine_T4     -3.587727e-02  2.796932e-02 -6.187393e-03
## Sarcosine_T4       8.030274e-02  3.455674e-02  7.832482e-03
## Serotonin_T4      -3.388582e-02  2.974088e-02 -6.891250e-03
## Taurine_T4         2.623844e-02 -4.701784e-02  9.123169e-03
## SDMA_T4            2.295269e-03 -4.370276e-03  6.662936e-02
## C0_T4              3.400223e-02 -3.899137e-02  5.009364e-03
## C2_T4              2.222563e-02 -2.574409e-02  3.447928e-02
## C3.OH_T4           4.816187e-03  3.260458e-03  5.013776e-02
## C6..C4.1.DC._T4   -4.391274e-02 -3.319275e-02 -6.991741e-03
## C5.DC..C6.OH._T4   1.550392e-02 -2.805756e-02  3.828026e-02
## C7.DC_T4           1.217091e-01  9.607679e-04  2.437349e-02
## C8_T4              3.519273e-03 -4.371217e-03  5.044278e-02
## C10_T4             1.297557e-03 -1.822612e-02 -6.798629e-03
## C10.1_T4           3.640459e-03 -3.928930e-03 -8.338528e-02
## C10.2_T4           3.037224e-03 -6.228832e-04 -1.008726e-02
## C14.1_T4          -9.808122e-05 -3.787365e-03  4.467123e-02
## C14.2_T4          -6.169711e-04 -2.561592e-03 -1.594554e-02
## C16.1_T4           2.447486e-02 -6.667934e-03 -4.399771e-02
## C16.2_T4           9.466180e-05 -1.980437e-03  4.605233e-03
## C16.2.OH_T4        2.531286e-02 -6.052545e-03  1.783496e-02
## C18.1_T4          -1.185532e-03 -3.546594e-03  4.738480e-02
## C18.1.OH_T4        1.354866e-03 -1.963221e-03  3.694975e-02
## C18.2_T4          -3.070343e-04 -2.076472e-03 -6.933576e-02
## lysoPC.a.C16.0_T4 -8.960688e-02 -3.130023e-02  1.753058e-02
## lysoPC.a.C16.1_T4 -5.560283e-02  1.490320e-02  4.911563e-02
## lysoPC.a.C17.0_T4 -1.179195e-02  2.248875e-03 -9.194845e-02
## lysoPC.a.C18.0_T4 -4.714478e-02 -4.680706e-02  1.056323e-02
## lysoPC.a.C18.1_T4 -5.669431e-02 -5.632950e-02  6.874862e-03
## lysoPC.a.C18.2_T4 -1.448296e-02 -8.277863e-02  1.452448e-02
## lysoPC.a.C20.3_T4 -1.400773e-02 -3.002468e-02 -7.443948e-02
## lysoPC.a.C20.4_T4  6.344671e-03 -1.796050e-02  7.658959e-03
## lysoPC.a.C24.0_T4 -5.356445e-04  3.634277e-03 -1.402007e-02
## lysoPC.a.C26.0_T4 -6.238993e-02  3.214101e-02 -1.999433e-02
## lysoPC.a.C26.1_T4  3.759218e-04  1.112320e-02  8.053970e-02
## lysoPC.a.C28.0_T4 -5.590914e-02  3.905935e-02  2.970499e-02
## lysoPC.a.C28.1_T4  1.224045e-03  7.215176e-03  3.887105e-02
## PC.aa.C24.0_T4    -4.145083e-03  2.459448e-01  6.987118e-03
## PC.aa.C28.1_T4    -5.360296e-04  2.017126e-02 -1.880529e-02
## PC.aa.C30.0_T4    -1.619341e-03  1.100443e-03  6.352610e-02
## PC.aa.C32.0_T4    -1.926690e-02 -2.022390e-02 -1.084107e-02
## PC.aa.C32.1_T4    -7.812108e-02 -4.428512e-02  1.904516e-02
## PC.aa.C32.3_T4     1.880629e-03 -6.574085e-04 -3.876031e-04
## PC.aa.C34.1_T4    -6.707279e-02 -1.640968e-02 -2.801755e-03
## PC.aa.C34.2_T4    -2.706243e-03  4.920455e-04  1.386172e-02
## PC.aa.C34.3_T4    -2.359548e-02 -1.675165e-02 -5.330119e-02
## PC.aa.C34.4_T4     2.502746e-03 -1.743923e-03 -5.287389e-03
## PC.aa.C36.0_T4     1.297474e-03 -2.655497e-02  4.523997e-02
## PC.aa.C36.1_T4    -3.077571e-02  8.609085e-03  3.718572e-02
## PC.aa.C36.2_T4     1.280266e-02  4.924081e-03  1.587826e-02
## PC.aa.C36.3_T4    -3.148612e-02  2.217078e-02  1.009993e-02
## PC.aa.C36.4_T4     2.719424e-02  4.958850e-02 -5.790704e-03
## PC.aa.C36.5_T4     3.298694e-03  1.003592e-02  5.192476e-03
## PC.aa.C38.0_T4    -3.572701e-03 -7.179518e-03  2.232846e-02
## PC.aa.C38.1_T4     1.713964e-02 -9.513107e-04  4.219611e-02
## PC.aa.C38.3_T4    -4.147320e-02  4.188911e-03  1.039604e-03
## PC.aa.C38.4_T4     3.182560e-02  5.823958e-02  1.315510e-02
## PC.aa.C38.5_T4    -5.532962e-02  1.427337e-02 -8.158666e-03
## PC.aa.C38.6_T4    -1.579986e-02 -1.663049e-02 -1.110512e-02
## PC.aa.C40.1_T4    -1.441520e-02  6.013732e-02 -4.036861e-03
## PC.aa.C40.2_T4    -6.841671e-03  3.642220e-03 -9.138817e-02
## PC.aa.C40.3_T4    -6.427382e-03  5.787821e-03 -3.140695e-02
## PC.aa.C40.4_T4    -3.037147e-02  7.677125e-03  4.649973e-02
## PC.aa.C40.5_T4    -6.474920e-02 -7.241818e-03 -1.199201e-02
## PC.aa.C40.6_T4     5.569195e-03  7.885848e-03 -1.084821e-03
## PC.aa.C42.0_T4     4.508229e-04 -5.331988e-05 -5.832180e-02
## PC.aa.C42.1_T4    -2.713788e-03 -4.278105e-03  3.932888e-02
## PC.aa.C42.2_T4    -1.665557e-03 -1.982422e-03  5.752484e-02
## PC.aa.C42.4_T4    -2.352722e-03  7.166621e-04 -5.318721e-02
## PC.aa.C42.5_T4    -5.792581e-04  1.183763e-04  6.545374e-03
## PC.aa.C42.6_T4    -6.889339e-02 -7.229025e-03 -2.549314e-02
## PC.ae.C30.0_T4    -5.351146e-02  2.606355e-02  3.114139e-02
## PC.ae.C32.1_T4     3.000401e-03 -2.245929e-02  8.214277e-02
## PC.ae.C32.2_T4     2.836318e-03 -8.452436e-04  2.929758e-02
## PC.ae.C34.0_T4     4.951641e-03  5.871521e-03  7.638271e-02
## PC.ae.C34.1_T4    -4.612759e-03 -1.459644e-02 -3.439298e-02
## PC.ae.C34.2_T4     2.265143e-02  1.537843e-02 -4.212153e-02
## PC.ae.C34.3_T4     7.519439e-03 -4.607384e-02 -5.229349e-02
## PC.ae.C36.0_T4     2.825495e-03  9.785216e-05  1.383733e-02
## PC.ae.C36.1_T4    -2.490455e-02  1.072065e-02  4.450703e-02
## PC.ae.C36.2_T4     2.693491e-02  2.998863e-02 -3.274973e-02
## PC.ae.C36.3_T4     7.183942e-03  1.170317e-02 -4.091323e-02
## PC.ae.C36.4_T4    -1.070167e-02  1.280544e-02  1.385070e-02
## PC.ae.C36.5_T4     1.964429e-02 -3.959434e-03 -6.019295e-02
## PC.ae.C38.0_T4    -6.896057e-03 -1.534156e-03  2.946692e-02
## PC.ae.C38.2_T4    -1.735111e-02 -7.607331e-03  3.038591e-02
## PC.ae.C38.3_T4    -1.699409e-02  6.688576e-03 -2.892272e-02
## PC.ae.C38.4_T4     2.954729e-02  2.231272e-02  3.468280e-02
## PC.ae.C38.5_T4    -6.448546e-03  2.579717e-02 -4.795265e-02
## PC.ae.C38.6_T4     1.913924e-03  2.072852e-02  6.447955e-02
## PC.ae.C40.1_T4     1.089495e-03  4.911733e-03 -8.162156e-02
## PC.ae.C40.2_T4     7.518083e-03  1.361354e-02 -3.705033e-02
## PC.ae.C40.3_T4    -1.041887e-02  2.388737e-03  5.896205e-02
## PC.ae.C40.4_T4    -1.882456e-03  9.731180e-03 -5.065285e-02
## PC.ae.C40.5_T4    -1.717635e-02  8.625078e-03  5.159758e-02
## PC.ae.C40.6_T4     3.770378e-03 -2.786326e-03 -8.823197e-02
## PC.ae.C42.1_T4    -6.142455e-03 -2.191074e-03 -2.138451e-02
## PC.ae.C42.2_T4    -7.627588e-03  3.756545e-04 -6.684848e-02
## PC.ae.C42.3_T4    -8.059620e-03 -3.842776e-03 -7.228746e-02
## PC.ae.C42.4_T4    -9.260045e-04  1.677662e-03  4.009022e-02
## PC.ae.C42.5_T4    -1.546865e-02  1.030788e-02 -5.391245e-02
## PC.ae.C44.3_T4    -1.002413e-04 -1.119134e-03 -4.566008e-02
## PC.ae.C44.4_T4    -1.178238e-03 -2.284230e-03  4.268307e-02
## PC.ae.C44.5_T4    -2.156955e-04  2.263205e-02 -7.925856e-02
## PC.ae.C44.6_T4    -1.049783e-03  1.083071e-03  8.453695e-03
## SM..OH..C14.1_T4   1.167771e-02  1.907123e-02  3.213269e-02
## SM..OH..C16.1_T4   8.344522e-03  1.253076e-03 -7.172978e-02
## SM..OH..C22.1_T4   2.297454e-02  1.149490e-02  3.079210e-02
## SM..OH..C22.2_T4   4.790855e-03 -7.214427e-03 -2.332117e-02
## SM..OH..C24.1_T4  -2.204073e-03 -3.331860e-03 -2.995442e-02
## SM.C16.0_T4       -3.629509e-02 -1.174250e-02  2.656754e-03
## SM.C16.1_T4       -2.045717e-02 -5.967919e-02 -8.954089e-03
## SM.C18.0_T4       -4.971794e-02  2.908138e-03 -2.636626e-03
## SM.C18.1_T4       -3.384185e-02 -4.320896e-02 -6.258848e-02
## SM.C20.2_T4        3.175940e-03 -9.998631e-04  3.420525e-03
## SM.C24.0_T4       -6.337337e-02  1.277187e-03 -6.819404e-02
## SM.C24.1_T4       -3.170051e-02  1.746461e-02 -3.934003e-03
## MEDDM_T5          -1.355341e-02  1.065473e-02 -1.856397e-03
## MEDCOL_T5         -1.355341e-02  1.065473e-02 -1.856397e-03
## MEDINF_T5         -3.345322e-02  9.419170e-03  6.979941e-02
## MEDHTA_T5         -1.164352e-02  4.741425e-03 -2.631707e-03
## GLU_T5            -5.735239e-02  3.918977e-02  1.692142e-03
## INS_T5            -1.084779e-03 -2.275484e-02  2.764159e-02
## HOMA_T5           -5.606631e-03 -9.078356e-03 -3.662978e-02
## HBA1C_T5          -7.477921e-03  3.337715e-03  1.113166e-01
## HBA1C.mmol.mol_T5 -3.450463e-02  1.399929e-03 -3.700645e-03
## PESO_T5           -1.160869e-02  2.357410e-02 -1.912528e-02
## bmi_T5             2.681734e-02  5.686409e-02 -4.008682e-04
## CC_T5             -2.313234e-04 -2.536317e-03 -9.411360e-02
## CINT_T5           -9.632960e-03 -1.595070e-02  1.938235e-02
## CAD_T5             2.496270e-02  2.643972e-02 -4.359005e-03
## TAD_T5            -9.626002e-02 -1.992305e-02  1.770690e-02
## TAS_T5            -4.958430e-02  2.855518e-03 -3.022694e-03
## TG_T5             -6.476389e-02  2.050843e-02 -1.410450e-02
## COL_T5            -5.198300e-02 -1.261013e-03  1.105661e-02
## LDL_T5            -9.605562e-02 -1.725291e-02  1.475917e-02
## HDL_T5             8.441686e-02  1.351849e-02  1.472178e-02
## VLDL_T5            4.349399e-02 -9.288720e-03  8.405263e-03
## PCR_T5            -6.989847e-02  6.588722e-03  5.109754e-02
## LEP_T5            -3.754050e-03 -2.313493e-02 -4.191885e-03
## ADIPO_T5           7.431132e-02  6.167638e-03 -2.135666e-02
## GOT_T5             1.175744e-02 -1.337260e-01 -8.053676e-03
## GPT_T5            -4.085770e-02 -7.531909e-03 -6.924883e-03
## GGT_T5            -2.795291e-02 -2.007005e-02  6.859558e-03
## URICO_T5           2.858849e-02 -5.738664e-03 -6.599193e-02
## CREAT_T5           2.855504e-03 -1.362841e-03 -6.764623e-04
## UREA_T5           -7.433651e-02  2.754515e-02  1.653994e-03
## HIERRO_T5          2.011792e-02 -2.532321e-02 -1.831837e-02
## TRANSF_T5         -3.471343e-02 -4.245654e-02 -3.027793e-02
## FERR_T5            2.830419e-02  1.056411e-02 -6.064023e-03
## Ile_T5             1.209890e-03  2.255629e-02 -1.762195e-02
## Leu_T5             3.154459e-02  5.447706e-02 -2.810685e-02
## Val_T5             3.074485e-02  6.251918e-02 -2.359785e-02
## Ala_T5            -2.948820e-02 -4.069985e-02 -1.977880e-04
## Pro_T5             2.412245e-02 -1.789637e-02  2.581798e-02
## Gly_T5             4.595468e-02  2.487049e-02  1.443400e-03
## Ser_T5            -5.594041e-02 -1.162319e-01  1.029631e-02
## Trp_T5            -7.724231e-03  3.058947e-02 -9.586423e-03
## Phe_T5             2.333795e-03 -1.433547e-02 -8.448475e-03
## Met_T5             4.189847e-03 -2.108631e-02 -1.334497e-02
## Orn_T5             8.866049e-02 -2.431777e-02  8.231751e-03
## Arg_T5            -7.977362e-02  6.180142e-03 -4.439346e-03
## His_T5             3.506819e-02  1.406799e-02 -1.243201e-02
## Asn_T5            -3.106037e-02 -9.255531e-02  1.249375e-03
## Asp_T5            -9.350662e-03 -1.659064e-02  7.789327e-03
## Glu_T5             9.057909e-03  1.520514e-02  1.068449e-02
## Gln_T5            -2.700433e-02 -5.631390e-02 -1.607484e-02
## Cit_T5             8.875381e-02  8.469419e-02 -1.316876e-02
## Tyr_T5            -2.859062e-02 -2.719041e-02  1.101594e-02
## Thr_T5             1.355772e-02  3.115909e-02  8.355677e-03
## Lys_T5            -1.725057e-03  7.545279e-02 -1.622664e-02
## Creatinine_T5     -3.811462e-02 -6.552830e-04 -5.675477e-03
## Kynurenine_T5     -5.630624e-03 -9.908932e-03  5.133936e-03
## Putrescine_T5     -2.512079e-02 -5.637051e-02 -7.545421e-04
## Sarcosine_T5      -5.636116e-02 -8.964666e-03  5.645416e-02
## Serotonin_T5       1.852217e-04  4.454626e-02 -1.057668e-02
## Taurine_T5         3.690367e-02  3.622172e-02  2.530137e-02
## SDMA_T5            3.800387e-03 -2.313339e-04 -4.692322e-02
## C0_T5              1.098738e-02  4.042561e-02  3.039335e-03
## C2_T5             -3.617009e-03  6.983443e-02  2.891759e-02
## C3.OH_T5           2.103310e-04 -7.996348e-04  6.593871e-02
## C6..C4.1.DC._T5   -5.379892e-02  2.856922e-02 -1.283106e-02
## C5.DC..C6.OH._T5   3.749286e-03  2.262026e-02  4.537416e-02
## C7.DC_T5           7.599385e-03  2.180520e-02 -9.640438e-04
## C8_T5             -5.454730e-04  5.484725e-04 -8.220196e-02
## C10_T5             1.906253e-04  2.807676e-04  7.915053e-02
## C10.1_T5           2.499350e-02  2.103898e-02  2.290239e-02
## C10.2_T5           1.988807e-03 -1.107701e-03  6.610145e-02
## C14.1_T5           1.313815e-03 -3.011631e-04  4.569542e-02
## C14.2_T5           2.504843e-03 -9.013067e-04 -1.814535e-02
## C16.1_T5           1.246863e-03 -9.844696e-04 -7.363480e-02
## C16.2_T5           2.100491e-03 -1.396385e-03 -5.612325e-02
## C16.2.OH_T5       -1.160820e-02 -5.760919e-02  3.406411e-02
## C18.1_T5           1.793672e-03 -1.827356e-03  7.063543e-02
## C18.1.OH_T5        1.748040e-03 -1.456364e-03  3.208977e-02
## C18.2_T5           1.415610e-03 -1.370468e-03  2.107264e-02
## lysoPC.a.C16.0_T5 -3.782188e-02 -1.352514e-02  2.366916e-02
## lysoPC.a.C16.1_T5 -3.249100e-02 -1.172365e-02  8.950006e-02
## lysoPC.a.C17.0_T5  5.826640e-03  8.617134e-03  3.935293e-02
## lysoPC.a.C18.0_T5 -3.954753e-02 -1.489427e-02  1.603754e-02
## lysoPC.a.C18.1_T5 -3.419054e-02 -3.678295e-02  3.115680e-03
## lysoPC.a.C18.2_T5 -3.986185e-02 -6.243956e-02  1.516870e-02
## lysoPC.a.C20.3_T5  1.067299e-02 -1.865153e-03 -8.087957e-02
## lysoPC.a.C20.4_T5  2.675864e-02 -2.464119e-02 -1.491142e-02
## lysoPC.a.C24.0_T5  1.743194e-04  6.928899e-04  3.459723e-02
## lysoPC.a.C26.0_T5 -9.197374e-04  2.715170e-03  3.056951e-02
## lysoPC.a.C26.1_T5  6.123316e-03  4.258241e-03 -2.264614e-02
## lysoPC.a.C28.0_T5  1.305923e-02  5.393367e-03 -8.463442e-03
## lysoPC.a.C28.1_T5  4.765891e-03  2.373059e-03  4.321967e-02
## PC.aa.C24.0_T5    -3.914160e-02 -2.519401e-02  2.896171e-02
## PC.aa.C28.1_T5     1.363425e-02  1.601661e-02  4.789620e-02
## PC.aa.C30.0_T5     7.139112e-03 -2.238949e-03  2.776106e-02
## PC.aa.C32.0_T5     3.010192e-02 -8.492821e-03 -2.730169e-03
## PC.aa.C32.1_T5     3.913081e-02 -2.260303e-03 -2.975586e-02
## PC.aa.C32.3_T5     2.808015e-03  8.106794e-05 -5.671490e-02
## PC.aa.C34.1_T5     1.646312e-03 -1.735917e-02  7.594419e-03
## PC.aa.C34.2_T5     5.903053e-03 -7.464588e-03 -5.700431e-04
## PC.aa.C34.3_T5     3.131404e-03  3.177634e-02 -2.423386e-02
## PC.aa.C34.4_T5     5.907215e-03  1.848646e-03  9.254655e-03
## PC.aa.C36.0_T5    -1.279086e-02  2.669540e-03  1.690902e-02
## PC.aa.C36.1_T5    -2.884510e-02 -1.314773e-02 -9.956478e-03
## PC.aa.C36.2_T5    -1.360047e-02 -1.112680e-02  5.702019e-03
## PC.aa.C36.3_T5     5.311960e-03  2.776806e-02  1.355275e-02
## PC.aa.C36.4_T5     5.782222e-02  1.066611e-02  2.012432e-02
## PC.aa.C36.5_T5     5.762082e-02  5.299252e-02  6.305850e-02
## PC.aa.C38.0_T5    -2.549500e-02  3.117129e-03  2.588167e-02
## PC.aa.C38.1_T5    -4.446399e-03  1.263475e-02 -5.199548e-02
## PC.aa.C38.3_T5     1.504606e-02  5.750614e-03 -3.254522e-03
## PC.aa.C38.4_T5     5.107536e-02  2.686804e-02  1.522907e-02
## PC.aa.C38.5_T5     1.792111e-02  5.100107e-02  2.963566e-04
## PC.aa.C38.6_T5    -3.855621e-02  3.298310e-02 -5.611348e-03
## PC.aa.C40.1_T5     1.941136e-02  7.775974e-05 -1.375261e-02
## PC.aa.C40.2_T5    -6.621693e-03  8.909918e-04 -4.261965e-02
## PC.aa.C40.3_T5    -3.578622e-03  2.207977e-03  6.294528e-03
## PC.aa.C40.4_T5    -9.535723e-03  2.568050e-03 -6.775539e-02
## PC.aa.C40.5_T5    -5.917441e-03  2.638173e-02 -3.730871e-02
## PC.aa.C40.6_T5    -2.159565e-02  3.688033e-02 -9.858462e-03
## PC.aa.C42.0_T5    -3.914248e-04 -3.461133e-03  4.156091e-02
## PC.aa.C42.1_T5     9.898823e-04 -1.601123e-03 -9.147108e-02
## PC.aa.C42.2_T5    -1.857462e-03 -6.513315e-04 -5.453200e-02
## PC.aa.C42.4_T5    -2.072377e-03 -1.472222e-03 -2.550724e-02
## PC.aa.C42.5_T5     1.612050e-03 -6.558268e-04  3.684300e-02
## PC.aa.C42.6_T5    -3.560559e-02 -2.444479e-02  5.494055e-02
## PC.ae.C30.0_T5    -1.725777e-02 -5.426048e-03  6.953575e-02
## PC.ae.C32.1_T5     8.500126e-03 -6.392108e-03 -6.656511e-02
## PC.ae.C32.2_T5     2.200527e-03  7.038120e-05 -1.549870e-02
## PC.ae.C34.0_T5     3.949858e-03 -2.644535e-03  4.533234e-03
## PC.ae.C34.1_T5     6.353584e-03  9.820413e-03 -5.550650e-04
## PC.ae.C34.2_T5     3.332195e-03  2.577345e-02 -5.008930e-03
## PC.ae.C34.3_T5    -1.275685e-02 -3.747289e-03 -2.856195e-02
## PC.ae.C36.0_T5    -3.400683e-03 -2.617800e-03 -5.315497e-02
## PC.ae.C36.1_T5    -1.828426e-02  8.805671e-03 -4.859012e-02
## PC.ae.C36.2_T5     1.340806e-02  2.216055e-02  5.390534e-02
## PC.ae.C36.3_T5    -2.701725e-03  1.710938e-02  8.981970e-03
## PC.ae.C36.4_T5     9.404803e-03  4.741814e-03 -2.063785e-02
## PC.ae.C36.5_T5     8.655186e-03 -7.132377e-03 -4.209059e-02
## PC.ae.C38.0_T5    -2.615771e-04  7.355251e-03 -4.071678e-02
## PC.ae.C38.2_T5    -1.536740e-02  1.052793e-02 -4.215303e-02
## PC.ae.C38.3_T5     1.380575e-03  1.162971e-02 -3.851715e-02
## PC.ae.C38.4_T5     2.258673e-02  1.264488e-02 -7.885753e-02
## PC.ae.C38.5_T5    -1.090380e-02  4.542478e-03  2.532075e-02
## PC.ae.C38.6_T5    -5.986093e-03  1.592318e-02 -4.694887e-03
## PC.ae.C40.1_T5    -8.836806e-03  1.433661e-03 -4.314543e-02
## PC.ae.C40.2_T5    -1.311426e-03  7.418267e-03 -8.725087e-02
## PC.ae.C40.3_T5    -6.951987e-03  2.466045e-03  5.589785e-02
## PC.ae.C40.4_T5     2.929965e-03  8.602193e-04  6.773652e-02
## PC.ae.C40.5_T5    -1.165546e-02 -1.341571e-03 -8.808593e-02
## PC.ae.C40.6_T5    -2.992650e-03  1.195146e-02  6.129472e-02
## PC.ae.C42.1_T5    -1.237884e-03  1.404401e-03 -1.168013e-02
## PC.ae.C42.2_T5    -3.618661e-03  2.300888e-03 -2.342941e-02
## PC.ae.C42.3_T5    -2.828074e-03  2.512145e-03  8.762658e-02
## PC.ae.C42.4_T5     5.500987e-03  1.799558e-03 -9.088007e-03
## PC.ae.C42.5_T5     9.395476e-04 -1.657487e-02 -4.251347e-02
## PC.ae.C44.3_T5    -3.845465e-04 -6.335177e-04  7.074290e-02
## PC.ae.C44.4_T5     3.830698e-05 -1.014468e-03  3.222213e-02
## PC.ae.C44.5_T5     1.661112e-02  1.792846e-03 -5.465262e-02
## PC.ae.C44.6_T5     1.804555e-02 -4.371308e-03  1.979390e-02
## SM..OH..C14.1_T5   2.992407e-03  3.117966e-02 -9.774168e-03
## SM..OH..C16.1_T5   6.404140e-03  7.955493e-03 -9.158340e-02
## SM..OH..C22.1_T5   7.688167e-03  3.093015e-02  3.970707e-03
## SM..OH..C22.2_T5   1.723052e-02  4.043607e-02  9.087486e-02
## SM..OH..C24.1_T5   6.480023e-03  3.595573e-03 -5.531856e-03
## SM.C16.0_T5       -7.941236e-03  4.357139e-02  9.050542e-03
## SM.C16.1_T5       -3.979627e-02  3.931582e-02  3.244983e-02
## SM.C18.0_T5       -4.862009e-02 -2.398544e-02  1.224432e-02
## SM.C18.1_T5       -3.089381e-02 -2.235646e-02 -2.918205e-02
## SM.C20.2_T5        4.011518e-03  4.858889e-04  4.032779e-04
## SM.C24.0_T5        1.628254e-02  3.878261e-02 -2.254805e-02
## SM.C24.1_T5        2.209519e-02  4.338080e-02  4.856202e-04
summary(PCAseMA)
## Importance of components:
##                            PC1     PC2     PC3     PC4     PC5     PC6     PC7
## Standard deviation     18.9326 7.37793 5.80678 5.36651 5.21288 4.42129 4.03210
## Proportion of Variance  0.5233 0.07947 0.04922 0.04204 0.03967 0.02854 0.02373
## Cumulative Proportion   0.5233 0.60274 0.65196 0.69401 0.73368 0.76221 0.78595
##                            PC8     PC9    PC10    PC11    PC12    PC13    PC14
## Standard deviation     3.61080 3.46476 2.99399 2.90510 2.84023 2.67100 2.63356
## Proportion of Variance 0.01903 0.01752 0.01309 0.01232 0.01178 0.01041 0.01013
## Cumulative Proportion  0.80498 0.82251 0.83559 0.84791 0.85969 0.87010 0.88023
##                           PC15   PC16    PC17    PC18    PC19    PC20    PC21
## Standard deviation     2.59189 2.5504 2.43882 2.28260 2.22287 2.11893 2.06772
## Proportion of Variance 0.00981 0.0095 0.00868 0.00761 0.00721 0.00655 0.00624
## Cumulative Proportion  0.89004 0.8995 0.90821 0.91582 0.92303 0.92959 0.93583
##                           PC22    PC23    PC24    PC25    PC26    PC27   PC28
## Standard deviation     2.04296 1.98508 1.88904 1.85318 1.80243 1.75920 1.7352
## Proportion of Variance 0.00609 0.00575 0.00521 0.00501 0.00474 0.00452 0.0044
## Cumulative Proportion  0.94192 0.94768 0.95289 0.95790 0.96264 0.96716 0.9716
##                           PC29    PC30    PC31    PC32    PC33    PC34    PC35
## Standard deviation     1.71137 1.62451 1.53198 1.49427 1.38232 1.37421 1.32833
## Proportion of Variance 0.00428 0.00385 0.00343 0.00326 0.00279 0.00276 0.00258
## Cumulative Proportion  0.97583 0.97968 0.98311 0.98637 0.98916 0.99192 0.99449
##                           PC36   PC37    PC38      PC39
## Standard deviation     1.22484 1.1091 1.02129 1.161e-14
## Proportion of Variance 0.00219 0.0018 0.00152 0.000e+00
## Cumulative Proportion  0.99668 0.9985 1.00000 1.000e+00

L’anàlisi no és molt concloent. Per obtenir un 70% de la variancia ens calen 5 components, el que és molt. Entenc que hi ha massa variables en joc i segurament caldria reduir abans d’alguna altra manera. Segurament hi ha explicacions biològiques que estaria bé aplicar, però a mi se m’escapen ja que no comprenc totes les variables.

# carreguem les dades pel gràfic
loads <- round(PCAseMA$sdev^2/sum(PCAseMA$sdev^2)*100,1)
groupColors <- c(rep("red", 4), rep("blue", 4))
xlab <- c(paste("PC1",loads[1],"%"))
ylab <- c(paste("PC2",loads[2],"%"))
# grafiquem
plot(PCAseMA$x[,1:2],
     xlab=xlab,
     ylab=ylab, 
     pch = c(3,21),
     col=c("blue","red"), 
     main ="Principal components (PCA)",
     ylim=c(-20,30))
names <- rownames(PCAseMA$x)
text(PCAseMA$x[,1],PCAseMA$x[,2],names, pos=3, cex=.6)

Lo unic destacable que s’aprecia és que la mostra 37 està a molta distància de la resta

library(plotly)
## Warning: package 'plotly' was built under R version 4.4.3
## Loading required package: ggplot2
## 
## Attaching package: 'plotly'
## The following object is masked from 'package:ggplot2':
## 
##     last_plot
## The following object is masked from 'package:IRanges':
## 
##     slice
## The following object is masked from 'package:S4Vectors':
## 
##     rename
## The following object is masked from 'package:stats':
## 
##     filter
## The following object is masked from 'package:graphics':
## 
##     layout
fig <- plot_ly(as.data.frame(assay(seMAnormalized)), 
               x = ~PCAseMA$x[,1], y = ~PCAseMA$x[,2], z = ~PCAseMA$x[,3]) %>%
  add_markers(marker = list(size = 3)) %>%
  layout(scene = list(xaxis = list(title = "PC1"),
                      yaxis = list(title = "PC2"),
                      zaxis = list(title = "PC3")))
fig

Ara ja són 3 els casos que se separen força de la resta

7. Cerca de patrons

Ho farem amb un heatmap de la matriu de correlacions que permetria veure totes les relacions

cor_matrix <- cor(na.omit(assay(seMAnormalized)))
heatmap(cor_matrix)

Es veuen dos grups de variables més correlacionades, però en general les correlacions són debils.

Ara fem un altre heatmap que calcula distancies entre les variables i les mostres

dist_matrix <- t(assay(seMAnormalized))
heatmap(dist_matrix, col=heat.colors(16))

Hi ha tantes mostres i variables que no es poden veure be totes les relacions, però sembla que hi ha un patró clar de proximitat en les primeres variables del gràfic i algunes que estan a molta distància cap a baix. Pel que fa a les mostres, la 37 es mostra clarament diferent a la resta com ja s’havia vist a la PCA