Anàlisi de dades òmiques (M0-157). PAC1.
Marc Anton
2025-03-28
1. Introducció
Aquest arxiu conté les sol·lucions analítiques als problemes plantejats en la PAC1 Anàlisi de dades òmiques (M0-157). El projecte total del treball es pot consultar al: meu repositori github, cliqueu aquí
2. Carrega de dades
Abans que res, carreguem les dades al nostre entorn de treball. Treballarem amb un dels exemples de mostra, veure aquí. Aquest exemple porta dos arxius, DataInfo_S013 i DataValues_S013. Carreguem els dos fitxers:
DataInfo_S013 <- read.csv("DataInfo_S013.csv", sep = ",")
DataValues_S013 <- read.csv("DataValues_S013.csv", sep = ",")Com és habitual amb dades òmiques, tenim moltes varibales i un nombre reduït de casos d’estudi. Tot i així, abans que res mirem l’estructura dels dos.
3. Eploració previa de les dades descarregades
dim(DataInfo_S013)## [1] 695 4dim(DataValues_S013)## [1] 39 696Aqui ja veiem que en l’arxiu Info hi ha 695 files que han de correspondre a les variables que hi ha a Values. En aquest darrer tenim 696 columnes i 39 files. Les files corresponen a cada cas d’estudi més les 695 columnes són les variables que es tenen de cada un d’ells.
Per veure què són les variables, mirem les 20 primeres files d’Info i podem fer-nos una idea.
head(DataInfo_S013,20)## X VarName varTpe Description
## 1 SUBJECTS SUBJECTS integer dataDesc
## 2 SURGERY SURGERY character dataDesc
## 3 AGE AGE integer dataDesc
## 4 GENDER GENDER character dataDesc
## 5 Group Group integer dataDesc
## 6 MEDDM_T0 MEDDM_T0 integer dataDesc
## 7 MEDCOL_T0 MEDCOL_T0 integer dataDesc
## 8 MEDINF_T0 MEDINF_T0 integer dataDesc
## 9 MEDHTA_T0 MEDHTA_T0 integer dataDesc
## 10 GLU_T0 GLU_T0 integer dataDesc
## 11 INS_T0 INS_T0 numeric dataDesc
## 12 HOMA_T0 HOMA_T0 numeric dataDesc
## 13 HBA1C_T0 HBA1C_T0 numeric dataDesc
## 14 HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0 numeric dataDesc
## 15 PESO_T0 PESO_T0 integer dataDesc
## 16 bmi_T0 bmi_T0 numeric dataDesc
## 17 CC_T0 CC_T0 numeric dataDesc
## 18 CINT_T0 CINT_T0 integer dataDesc
## 19 CAD_T0 CAD_T0 integer dataDesc
## 20 TAD_T0 TAD_T0 integer dataDescAqui ja veiem que hi ha 9 primers camps que semblen ser els que tenen la informació sobre el pacient de cada mostra. Mirem que contenen aquests camps a values:
# En mirem 10 en realitat, per comprovar que la primera columna és un index
head(DataValues_S013[,1:10])## X.1 SUBJECTS SURGERY AGE GENDER Group MEDDM_T0 MEDCOL_T0 MEDINF_T0 MEDHTA_T0
## 1 1 1 by pass 27 F 1 0 0 0 1
## 2 2 2 by pass 19 F 2 0 0 0 0
## 3 3 3 by pass 42 F 1 0 0 0 0
## 4 4 4 by pass 37 F 2 0 0 0 0
## 5 5 5 tubular 42 F 1 0 0 0 0
## 6 6 6 by pass 24 F 2 0 0 0 0Com suposavem, aquestes columnes corresponen a: 1. Un codi de pacient (que està repetit a les dues primeres columnes, d’aquí que hi hagi una fila més a Info que columnes a Values) 2. La cirugia a la que va ser sotmés el pacient 3. L’edat i el gènere 4. Un grup de tractament 5. 4 tractaments que venen amb 0 i 1
Per veure que la resta són variables metabòliques, mirem 10 columnes més
head(DataValues_S013[,11:20],10)## GLU_T0 INS_T0 HOMA_T0 HBA1C_T0 HBA1C.mmol.mol_T0 PESO_T0 bmi_T0 CC_T0
## 1 85 11.40 2.40 NA NA 151 62.9 0.7
## 2 78 12.10 2.32 NA NA 139 47.0 NA
## 3 75 8.41 1.56 5.4 35.51 84 29.8 0.7
## 4 71 12.80 2.25 5.1 32.23 136 53.1 1.0
## 5 82 6.01 1.22 5.6 37.69 121 46.6 0.9
## 6 71 9.88 1.73 5.1 32.23 148 48.8 0.7
## 7 80 9.20 1.82 5.6 37.69 109 43.7 0.9
## 8 90 3.40 0.76 5.5 36.60 109 41.8 0.9
## 9 92 5.43 1.23 5.7 38.78 114 44.0 0.9
## 10 84 6.98 1.45 5.5 36.60 120 40.6 NA
## CINT_T0 CAD_T0
## 1 116 167
## 2 NA NA
## 3 90 126
## 4 157 162
## 5 123 132
## 6 110 148
## 7 122 141
## 8 124 136
## 9 136 148
## 10 NA NAObviament ja ho veiem i també podem veure que hi ha més d’un valor que no es té per a alguna de les variables (NA). Anem a veure si n’hi ha molts
sum(is.na(DataValues_S013))/(dim(DataValues_S013)[1]*dim(DataValues_S013)[2])## [1] 0.1248895Això apunta a que tenim un 12,5% de valors desconeguts. Aquest és un aspecte que caldrà tenir en compte en els anàlisi posteriors
4. Generació de l’obsject SummarizedExperiment
Ara que ja sabem que tenim a les dades, podem procedir a carregar-les en un objecte SummarizedExperiment. Per a fer-ho, convertirem però les dades a un data frame i li traurem la primera columna que ja hem vist que és redundant amb la segona. Aleshores ja ho podem carregar. En concret, carregarem:
- Les dades de les 9 primeres columnes (obviant la primera que esta duplicada) de DataVAlues corresponen a dades dels pacients que els guardarem com a rowData ja que no formen part de l’anàlisi dels metabolits
- La resta de dades de DataValues seràn els assays que és on es guarden les dades de les mostres que tenim
- L’arxiu DataInfo com a colData que és on es guarda la informació de com és cada columna d’assays. D’aquí només hem d’agafar la part corresponent als metabolits. És a dir de la fila 11 endavant.
# Primer carreguem la llibreria per poder tractar el SummarizedExperiment
library(SummarizedExperiment)## Loading required package: MatrixGenerics## Loading required package: matrixStats##
## Attaching package: 'MatrixGenerics'## The following objects are masked from 'package:matrixStats':
##
## colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse,
## colCounts, colCummaxs, colCummins, colCumprods, colCumsums,
## colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs,
## colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
## colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds,
## colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads,
## colWeightedMeans, colWeightedMedians, colWeightedSds,
## colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet,
## rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods,
## rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps,
## rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins,
## rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks,
## rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars,
## rowWeightedMads, rowWeightedMeans, rowWeightedMedians,
## rowWeightedSds, rowWeightedVars## Loading required package: GenomicRanges## Loading required package: stats4## Loading required package: BiocGenerics##
## Attaching package: 'BiocGenerics'## The following objects are masked from 'package:stats':
##
## IQR, mad, sd, var, xtabs## The following objects are masked from 'package:base':
##
## anyDuplicated, aperm, append, as.data.frame, basename, cbind,
## colnames, dirname, do.call, duplicated, eval, evalq, Filter, Find,
## get, grep, grepl, intersect, is.unsorted, lapply, Map, mapply,
## match, mget, order, paste, pmax, pmax.int, pmin, pmin.int,
## Position, rank, rbind, Reduce, rownames, sapply, saveRDS, setdiff,
## table, tapply, union, unique, unsplit, which.max, which.min## Loading required package: S4Vectors##
## Attaching package: 'S4Vectors'## The following object is masked from 'package:utils':
##
## findMatches## The following objects are masked from 'package:base':
##
## expand.grid, I, unname## Loading required package: IRanges##
## Attaching package: 'IRanges'## The following object is masked from 'package:grDevices':
##
## windows## Loading required package: GenomeInfoDb## Loading required package: Biobase## Welcome to Bioconductor
##
## Vignettes contain introductory material; view with
## 'browseVignettes()'. To cite Bioconductor, see
## 'citation("Biobase")', and for packages 'citation("pkgname")'.##
## Attaching package: 'Biobase'## The following object is masked from 'package:MatrixGenerics':
##
## rowMedians## The following objects are masked from 'package:matrixStats':
##
## anyMissing, rowMedians# Després generem les dades de pacients i de metabolits i la llista de rownames que volem tal i com hem indicat al text
pacients <- DataValues_S013[,2:10]
metabolits <- DataValues_S013[,11:696]
colNames <- DataInfo_S013[10:695,]
# Ara ja podem carregar el SummarizedExperiment
seMA <- SummarizedExperiment(assays = list(counts = as.matrix(metabolits)),
colData = colNames,
rowData = pacients)
seMA## class: SummarizedExperiment
## dim: 39 686
## metadata(0):
## assays(1): counts
## rownames: NULL
## rowData names(9): SUBJECTS SURGERY ... MEDINF_T0 MEDHTA_T0
## colnames(686): GLU_T0 INS_T0 ... SM.C24.0_T5 SM.C24.1_T5
## colData names(4): X VarName varTpe DescriptionSembla que l’objecte s’ha generat correctament
Mirem un parell de funcions que es poden fer.
# Comprovem com es diuen les columnes que tenim en cada una de les classes de dins de l'objecte
dimnames(seMA)## [[1]]
## NULL
##
## [[2]]
## [1] "GLU_T0" "INS_T0" "HOMA_T0"
## [4] "HBA1C_T0" "HBA1C.mmol.mol_T0" "PESO_T0"
## [7] "bmi_T0" "CC_T0" "CINT_T0"
## [10] "CAD_T0" "TAD_T0" "TAS_T0"
## [13] "TG_T0" "COL_T0" "LDL_T0"
## [16] "HDL_T0" "VLDL_T0" "PCR_T0"
## [19] "LEP_T0" "ADIPO_T0" "GOT_T0"
## [22] "GPT_T0" "GGT_T0" "URICO_T0"
## [25] "CREAT_T0" "UREA_T0" "HIERRO_T0"
## [28] "TRANSF_T0" "FERR_T0" "Ile_T0"
## [31] "Leu_T0" "Val_T0" "Ala_T0"
## [34] "Pro_T0" "Gly_T0" "Ser_T0"
## [37] "Trp_T0" "Phe_T0" "Met_T0"
## [40] "Orn_T0" "Arg_T0" "His_T0"
## [43] "Asn_T0" "Asp_T0" "Glu_T0"
## [46] "Gln_T0" "Cit_T0" "Tyr_T0"
## [49] "Thr_T0" "Lys_T0" "Creatinine_T0"
## [52] "Kynurenine_T0" "Putrescine_T0" "Sarcosine_T0"
## [55] "Serotonin_T0" "Taurine_T0" "SDMA_T0"
## [58] "C0_T0" "C2_T0" "C3.OH_T0"
## [61] "C6..C4.1.DC._T0" "C5.DC..C6.OH._T0" "C7.DC_T0"
## [64] "C8_T0" "C10_T0" "C10.1_T0"
## [67] "C10.2_T0" "C14.1_T0" "C14.2_T0"
## [70] "C16.1_T0" "C16.2_T0" "C16.2.OH_T0"
## [73] "C18.1_T0" "C18.1.OH_T0" "C18.2_T0"
## [76] "lysoPC.a.C16.0_T0" "lysoPC.a.C16.1_T0" "lysoPC.a.C17.0_T0"
## [79] "lysoPC.a.C18.0_T0" "lysoPC.a.C18.1_T0" "lysoPC.a.C18.2_T0"
## [82] "lysoPC.a.C20.3_T0" "lysoPC.a.C20.4_T0" "lysoPC.a.C24.0_T0"
## [85] "lysoPC.a.C26.0_T0" "lysoPC.a.C26.1_T0" "lysoPC.a.C28.0_T0"
## [88] "lysoPC.a.C28.1_T0" "PC.aa.C24.0_T0" "PC.aa.C28.1_T0"
## [91] "PC.aa.C30.0_T0" "PC.aa.C32.0_T0" "PC.aa.C32.1_T0"
## [94] "PC.aa.C32.3_T0" "PC.aa.C34.1_T0" "PC.aa.C34.2_T0"
## [97] "PC.aa.C34.3_T0" "PC.aa.C34.4_T0" "PC.aa.C36.0_T0"
## [100] "PC.aa.C36.1_T0" "PC.aa.C36.2_T0" "PC.aa.C36.3_T0"
## [103] "PC.aa.C36.4_T0" "PC.aa.C36.5_T0" "PC.aa.C38.0_T0"
## [106] "PC.aa.C38.1_T0" "PC.aa.C38.3_T0" "PC.aa.C38.4_T0"
## [109] "PC.aa.C38.5_T0" "PC.aa.C38.6_T0" "PC.aa.C40.1_T0"
## [112] "PC.aa.C40.2_T0" "PC.aa.C40.3_T0" "PC.aa.C40.4_T0"
## [115] "PC.aa.C40.5_T0" "PC.aa.C40.6_T0" "PC.aa.C42.0_T0"
## [118] "PC.aa.C42.1_T0" "PC.aa.C42.2_T0" "PC.aa.C42.4_T0"
## [121] "PC.aa.C42.5_T0" "PC.aa.C42.6_T0" "PC.ae.C30.0_T0"
## [124] "PC.ae.C32.1_T0" "PC.ae.C32.2_T0" "PC.ae.C34.0_T0"
## [127] "PC.ae.C34.1_T0" "PC.ae.C34.2_T0" "PC.ae.C34.3_T0"
## [130] "PC.ae.C36.0_T0" "PC.ae.C36.1_T0" "PC.ae.C36.2_T0"
## [133] "PC.ae.C36.3_T0" "PC.ae.C36.4_T0" "PC.ae.C36.5_T0"
## [136] "PC.ae.C38.0_T0" "PC.ae.C38.2_T0" "PC.ae.C38.3_T0"
## [139] "PC.ae.C38.4_T0" "PC.ae.C38.5_T0" "PC.ae.C38.6_T0"
## [142] "PC.ae.C40.1_T0" "PC.ae.C40.2_T0" "PC.ae.C40.3_T0"
## [145] "PC.ae.C40.4_T0" "PC.ae.C40.5_T0" "PC.ae.C40.6_T0"
## [148] "PC.ae.C42.1_T0" "PC.ae.C42.2_T0" "PC.ae.C42.3_T0"
## [151] "PC.ae.C42.4_T0" "PC.ae.C42.5_T0" "PC.ae.C44.3_T0"
## [154] "PC.ae.C44.4_T0" "PC.ae.C44.5_T0" "PC.ae.C44.6_T0"
## [157] "SM..OH..C14.1_T0" "SM..OH..C16.1_T0" "SM..OH..C22.1_T0"
## [160] "SM..OH..C22.2_T0" "SM..OH..C24.1_T0" "SM.C16.0_T0"
## [163] "SM.C16.1_T0" "SM.C18.0_T0" "SM.C18.1_T0"
## [166] "SM.C20.2_T0" "SM.C24.0_T0" "SM.C24.1_T0"
## [169] "MEDDM_T2" "MEDCOL_T2" "MEDINF_T2"
## [172] "MEDHTA_T2" "GLU_T2" "INS_T2"
## [175] "HOMA_T2" "HBA1C_T2" "HBA1C.mmol.mol_T2"
## [178] "PESO_T2" "bmi_T2" "CC_T2"
## [181] "CINT_T2" "CAD_T2" "TAD_T2"
## [184] "TAS_T2" "TG_T2" "COL_T2"
## [187] "LDL_T2" "HDL_T2" "VLDL_T2"
## [190] "PCR_T2" "LEP_T2" "ADIPO_T2"
## [193] "GOT_T2" "GPT_T2" "GGT_T2"
## [196] "URICO_T2" "CREAT_T2" "UREA_T2"
## [199] "HIERRO_T2" "TRANSF_T2" "FERR_T2"
## [202] "Ile_T2" "Leu_T2" "Val_T2"
## [205] "Ala_T2" "Pro_T2" "Gly_T2"
## [208] "Ser_T2" "Trp_T2" "Phe_T2"
## [211] "Met_T2" "Orn_T2" "Arg_T2"
## [214] "His_T2" "Asn_T2" "Asp_T2"
## [217] "Glu_T2" "Gln_T2" "Cit_T2"
## [220] "Tyr_T2" "Thr_T2" "Lys_T2"
## [223] "Creatinine_T2" "Kynurenine_T2" "Putrescine_T2"
## [226] "Sarcosine_T2" "Serotonin_T2" "Taurine_T2"
## [229] "SDMA_T2" "C0_T2" "C2_T2"
## [232] "C3.OH_T2" "C6..C4.1.DC._T2" "C5.DC..C6.OH._T2"
## [235] "C7.DC_T2" "C8_T2" "C10_T2"
## [238] "C10.1_T2" "C10.2_T2" "C14.1_T2"
## [241] "C14.2_T2" "C16.1_T2" "C16.2_T2"
## [244] "C16.2.OH_T2" "C18.1_T2" "C18.1.OH_T2"
## [247] "C18.2_T2" "X" "lysoPC.a.C14.0_T2"
## [250] "lysoPC.a.C16.0_T2" "lysoPC.a.C16.1_T2" "lysoPC.a.C17.0_T2"
## [253] "lysoPC.a.C18.0_T2" "lysoPC.a.C18.1_T2" "lysoPC.a.C18.2_T2"
## [256] "lysoPC.a.C20.3_T2" "lysoPC.a.C20.4_T2" "lysoPC.a.C24.0_T2"
## [259] "lysoPC.a.C26.0_T2" "lysoPC.a.C26.1_T2" "lysoPC.a.C28.0_T2"
## [262] "lysoPC.a.C28.1_T2" "PC.aa.C24.0_T2" "PC.aa.C28.1_T2"
## [265] "PC.aa.C30.0_T2" "PC.aa.C32.0_T2" "PC.aa.C32.1_T2"
## [268] "PC.aa.C32.3_T2" "PC.aa.C34.1_T2" "PC.aa.C34.2_T2"
## [271] "PC.aa.C34.3_T2" "PC.aa.C34.4_T2" "PC.aa.C36.0_T2"
## [274] "PC.aa.C36.1_T2" "PC.aa.C36.2_T2" "PC.aa.C36.3_T2"
## [277] "PC.aa.C36.4_T2" "PC.aa.C36.5_T2" "PC.aa.C38.0_T2"
## [280] "PC.aa.C38.1_T2" "PC.aa.C38.3_T2" "PC.aa.C38.4_T2"
## [283] "PC.aa.C38.5_T2" "PC.aa.C38.6_T2" "PC.aa.C40.1_T2"
## [286] "PC.aa.C40.2_T2" "PC.aa.C40.3_T2" "PC.aa.C40.4_T2"
## [289] "PC.aa.C40.5_T2" "PC.aa.C40.6_T2" "PC.aa.C42.0_T2"
## [292] "PC.aa.C42.1_T2" "PC.aa.C42.2_T2" "PC.aa.C42.4_T2"
## [295] "PC.aa.C42.5_T2" "PC.aa.C42.6_T2" "PC.ae.C30.0_T2"
## [298] "PC.ae.C32.1_T2" "PC.ae.C32.2_T2" "PC.ae.C34.0_T2"
## [301] "PC.ae.C34.1_T2" "PC.ae.C34.2_T2" "PC.ae.C34.3_T2"
## [304] "PC.ae.C36.0_T2" "PC.ae.C36.1_T2" "PC.ae.C36.2_T2"
## [307] "PC.ae.C36.3_T2" "PC.ae.C36.4_T2" "PC.ae.C36.5_T2"
## [310] "PC.ae.C38.0_T2" "PC.ae.C38.2_T2" "PC.ae.C38.3_T2"
## [313] "PC.ae.C38.4_T2" "PC.ae.C38.5_T2" "PC.ae.C38.6_T2"
## [316] "PC.ae.C40.1_T2" "PC.ae.C40.2_T2" "PC.ae.C40.3_T2"
## [319] "PC.ae.C40.4_T2" "PC.ae.C40.5_T2" "PC.ae.C40.6_T2"
## [322] "PC.ae.C42.1_T2" "PC.ae.C42.2_T2" "PC.ae.C42.3_T2"
## [325] "PC.ae.C42.4_T2" "PC.ae.C42.5_T2" "PC.ae.C44.3_T2"
## [328] "PC.ae.C44.4_T2" "PC.ae.C44.5_T2" "PC.ae.C44.6_T2"
## [331] "SM..OH..C14.1_T2" "SM..OH..C16.1_T2" "SM..OH..C22.1_T2"
## [334] "SM..OH..C22.2_T2" "SM..OH..C24.1_T2" "SM.C16.0_T2"
## [337] "SM.C16.1_T2" "SM.C18.0_T2" "SM.C18.1_T2"
## [340] "SM.C20.2_T2" "SM.C24.0_T2" "SM.C24.1_T2"
## [343] "MEDDM_T4" "MEDCOL_T4" "MEDINF_T4"
## [346] "MEDHTA_T4" "GLU_T4" "INS_T4"
## [349] "HOMA_T4" "HBA1C_T4" "HBA1C.mmol.mol_T4"
## [352] "PESO_T4" "bmi_T4" "CC_T4"
## [355] "CINT_T4" "CAD_T4" "TAD_T4"
## [358] "TAS_T4" "TG_T4" "COL_T4"
## [361] "LDL_T4" "HDL_T4" "VLDL_T4"
## [364] "PCR_T4" "LEP_T4" "ADIPO_T4"
## [367] "GOT_T4" "GPT_T4" "GGT_T4"
## [370] "URICO_T4" "CREAT_T4" "UREA_T4"
## [373] "HIERRO_T4" "TRANSF_T4" "FERR_T4"
## [376] "Ile_T4" "Leu_T4" "Val_T4"
## [379] "Ala_T4" "Pro_T4" "Gly_T4"
## [382] "Ser_T4" "Trp_T4" "Phe_T4"
## [385] "Met_T4" "Orn_T4" "Arg_T4"
## [388] "His_T4" "Asn_T4" "Asp_T4"
## [391] "Glu_T4" "Gln_T4" "Cit_T4"
## [394] "Tyr_T4" "Thr_T4" "Lys_T4"
## [397] "Creatinine_T4" "Kynurenine_T4" "Putrescine_T4"
## [400] "Sarcosine_T4" "Serotonin_T4" "Taurine_T4"
## [403] "SDMA_T4" "C0_T4" "C2_T4"
## [406] "C3.OH_T4" "C6..C4.1.DC._T4" "C5.DC..C6.OH._T4"
## [409] "C7.DC_T4" "C8_T4" "C10_T4"
## [412] "C10.1_T4" "C10.2_T4" "C14.1_T4"
## [415] "C14.2_T4" "C16.1_T4" "C16.2_T4"
## [418] "C16.2.OH_T4" "C18.1_T4" "C18.1.OH_T4"
## [421] "C18.2_T4" "lysoPC.a.C16.0_T4" "lysoPC.a.C16.1_T4"
## [424] "lysoPC.a.C17.0_T4" "lysoPC.a.C18.0_T4" "lysoPC.a.C18.1_T4"
## [427] "lysoPC.a.C18.2_T4" "lysoPC.a.C20.3_T4" "lysoPC.a.C20.4_T4"
## [430] "lysoPC.a.C24.0_T4" "lysoPC.a.C26.0_T4" "lysoPC.a.C26.1_T4"
## [433] "lysoPC.a.C28.0_T4" "lysoPC.a.C28.1_T4" "PC.aa.C24.0_T4"
## [436] "PC.aa.C28.1_T4" "PC.aa.C30.0_T4" "PC.aa.C32.0_T4"
## [439] "PC.aa.C32.1_T4" "PC.aa.C32.3_T4" "PC.aa.C34.1_T4"
## [442] "PC.aa.C34.2_T4" "PC.aa.C34.3_T4" "PC.aa.C34.4_T4"
## [445] "PC.aa.C36.0_T4" "PC.aa.C36.1_T4" "PC.aa.C36.2_T4"
## [448] "PC.aa.C36.3_T4" "PC.aa.C36.4_T4" "PC.aa.C36.5_T4"
## [451] "PC.aa.C38.0_T4" "PC.aa.C38.1_T4" "PC.aa.C38.3_T4"
## [454] "PC.aa.C38.4_T4" "PC.aa.C38.5_T4" "PC.aa.C38.6_T4"
## [457] "PC.aa.C40.1_T4" "PC.aa.C40.2_T4" "PC.aa.C40.3_T4"
## [460] "PC.aa.C40.4_T4" "PC.aa.C40.5_T4" "PC.aa.C40.6_T4"
## [463] "PC.aa.C42.0_T4" "PC.aa.C42.1_T4" "PC.aa.C42.2_T4"
## [466] "PC.aa.C42.4_T4" "PC.aa.C42.5_T4" "PC.aa.C42.6_T4"
## [469] "PC.ae.C30.0_T4" "PC.ae.C32.1_T4" "PC.ae.C32.2_T4"
## [472] "PC.ae.C34.0_T4" "PC.ae.C34.1_T4" "PC.ae.C34.2_T4"
## [475] "PC.ae.C34.3_T4" "PC.ae.C36.0_T4" "PC.ae.C36.1_T4"
## [478] "PC.ae.C36.2_T4" "PC.ae.C36.3_T4" "PC.ae.C36.4_T4"
## [481] "PC.ae.C36.5_T4" "PC.ae.C38.0_T4" "PC.ae.C38.2_T4"
## [484] "PC.ae.C38.3_T4" "PC.ae.C38.4_T4" "PC.ae.C38.5_T4"
## [487] "PC.ae.C38.6_T4" "PC.ae.C40.1_T4" "PC.ae.C40.2_T4"
## [490] "PC.ae.C40.3_T4" "PC.ae.C40.4_T4" "PC.ae.C40.5_T4"
## [493] "PC.ae.C40.6_T4" "PC.ae.C42.1_T4" "PC.ae.C42.2_T4"
## [496] "PC.ae.C42.3_T4" "PC.ae.C42.4_T4" "PC.ae.C42.5_T4"
## [499] "PC.ae.C44.3_T4" "PC.ae.C44.4_T4" "PC.ae.C44.5_T4"
## [502] "PC.ae.C44.6_T4" "SM..OH..C14.1_T4" "SM..OH..C16.1_T4"
## [505] "SM..OH..C22.1_T4" "SM..OH..C22.2_T4" "SM..OH..C24.1_T4"
## [508] "SM.C16.0_T4" "SM.C16.1_T4" "SM.C18.0_T4"
## [511] "SM.C18.1_T4" "SM.C20.2_T4" "SM.C24.0_T4"
## [514] "SM.C24.1_T4" "MEDDM_T5" "MEDCOL_T5"
## [517] "MEDINF_T5" "MEDHTA_T5" "GLU_T5"
## [520] "INS_T5" "HOMA_T5" "HBA1C_T5"
## [523] "HBA1C.mmol.mol_T5" "PESO_T5" "bmi_T5"
## [526] "CC_T5" "CINT_T5" "CAD_T5"
## [529] "TAD_T5" "TAS_T5" "TG_T5"
## [532] "COL_T5" "LDL_T5" "HDL_T5"
## [535] "VLDL_T5" "PCR_T5" "LEP_T5"
## [538] "ADIPO_T5" "GOT_T5" "GPT_T5"
## [541] "GGT_T5" "URICO_T5" "CREAT_T5"
## [544] "UREA_T5" "HIERRO_T5" "TRANSF_T5"
## [547] "FERR_T5" "Ile_T5" "Leu_T5"
## [550] "Val_T5" "Ala_T5" "Pro_T5"
## [553] "Gly_T5" "Ser_T5" "Trp_T5"
## [556] "Phe_T5" "Met_T5" "Orn_T5"
## [559] "Arg_T5" "His_T5" "Asn_T5"
## [562] "Asp_T5" "Glu_T5" "Gln_T5"
## [565] "Cit_T5" "Tyr_T5" "Thr_T5"
## [568] "Lys_T5" "Creatinine_T5" "Kynurenine_T5"
## [571] "Putrescine_T5" "Sarcosine_T5" "Serotonin_T5"
## [574] "Taurine_T5" "SDMA_T5" "C0_T5"
## [577] "C2_T5" "C3.OH_T5" "C6..C4.1.DC._T5"
## [580] "C5.DC..C6.OH._T5" "C7.DC_T5" "C8_T5"
## [583] "C10_T5" "C10.1_T5" "C10.2_T5"
## [586] "C14.1_T5" "C14.2_T5" "C16.1_T5"
## [589] "C16.2_T5" "C16.2.OH_T5" "C18.1_T5"
## [592] "C18.1.OH_T5" "C18.2_T5" "lysoPC.a.C16.0_T5"
## [595] "lysoPC.a.C16.1_T5" "lysoPC.a.C17.0_T5" "lysoPC.a.C18.0_T5"
## [598] "lysoPC.a.C18.1_T5" "lysoPC.a.C18.2_T5" "lysoPC.a.C20.3_T5"
## [601] "lysoPC.a.C20.4_T5" "lysoPC.a.C24.0_T5" "lysoPC.a.C26.0_T5"
## [604] "lysoPC.a.C26.1_T5" "lysoPC.a.C28.0_T5" "lysoPC.a.C28.1_T5"
## [607] "PC.aa.C24.0_T5" "PC.aa.C28.1_T5" "PC.aa.C30.0_T5"
## [610] "PC.aa.C32.0_T5" "PC.aa.C32.1_T5" "PC.aa.C32.3_T5"
## [613] "PC.aa.C34.1_T5" "PC.aa.C34.2_T5" "PC.aa.C34.3_T5"
## [616] "PC.aa.C34.4_T5" "PC.aa.C36.0_T5" "PC.aa.C36.1_T5"
## [619] "PC.aa.C36.2_T5" "PC.aa.C36.3_T5" "PC.aa.C36.4_T5"
## [622] "PC.aa.C36.5_T5" "PC.aa.C38.0_T5" "PC.aa.C38.1_T5"
## [625] "PC.aa.C38.3_T5" "PC.aa.C38.4_T5" "PC.aa.C38.5_T5"
## [628] "PC.aa.C38.6_T5" "PC.aa.C40.1_T5" "PC.aa.C40.2_T5"
## [631] "PC.aa.C40.3_T5" "PC.aa.C40.4_T5" "PC.aa.C40.5_T5"
## [634] "PC.aa.C40.6_T5" "PC.aa.C42.0_T5" "PC.aa.C42.1_T5"
## [637] "PC.aa.C42.2_T5" "PC.aa.C42.4_T5" "PC.aa.C42.5_T5"
## [640] "PC.aa.C42.6_T5" "PC.ae.C30.0_T5" "PC.ae.C32.1_T5"
## [643] "PC.ae.C32.2_T5" "PC.ae.C34.0_T5" "PC.ae.C34.1_T5"
## [646] "PC.ae.C34.2_T5" "PC.ae.C34.3_T5" "PC.ae.C36.0_T5"
## [649] "PC.ae.C36.1_T5" "PC.ae.C36.2_T5" "PC.ae.C36.3_T5"
## [652] "PC.ae.C36.4_T5" "PC.ae.C36.5_T5" "PC.ae.C38.0_T5"
## [655] "PC.ae.C38.2_T5" "PC.ae.C38.3_T5" "PC.ae.C38.4_T5"
## [658] "PC.ae.C38.5_T5" "PC.ae.C38.6_T5" "PC.ae.C40.1_T5"
## [661] "PC.ae.C40.2_T5" "PC.ae.C40.3_T5" "PC.ae.C40.4_T5"
## [664] "PC.ae.C40.5_T5" "PC.ae.C40.6_T5" "PC.ae.C42.1_T5"
## [667] "PC.ae.C42.2_T5" "PC.ae.C42.3_T5" "PC.ae.C42.4_T5"
## [670] "PC.ae.C42.5_T5" "PC.ae.C44.3_T5" "PC.ae.C44.4_T5"
## [673] "PC.ae.C44.5_T5" "PC.ae.C44.6_T5" "SM..OH..C14.1_T5"
## [676] "SM..OH..C16.1_T5" "SM..OH..C22.1_T5" "SM..OH..C22.2_T5"
## [679] "SM..OH..C24.1_T5" "SM.C16.0_T5" "SM.C16.1_T5"
## [682] "SM.C18.0_T5" "SM.C18.1_T5" "SM.C20.2_T5"
## [685] "SM.C24.0_T5" "SM.C24.1_T5"# I ara mirem les 10 primeres columnes i les 5 primeres files d'assays
assay(seMA)[1:5, 1:10]## GLU_T0 INS_T0 HOMA_T0 HBA1C_T0 HBA1C.mmol.mol_T0 PESO_T0 bmi_T0 CC_T0
## [1,] 85 11.40 2.40 NA NA 151 62.9 0.7
## [2,] 78 12.10 2.32 NA NA 139 47.0 NA
## [3,] 75 8.41 1.56 5.4 35.51 84 29.8 0.7
## [4,] 71 12.80 2.25 5.1 32.23 136 53.1 1.0
## [5,] 82 6.01 1.22 5.6 37.69 121 46.6 0.9
## CINT_T0 CAD_T0
## [1,] 116 167
## [2,] NA NA
## [3,] 90 126
## [4,] 157 162
## [5,] 123 132# I també mirem com ha quedat colData
colData(seMA)## DataFrame with 686 rows and 4 columns
## X VarName varTpe Description
## <character> <character> <character> <character>
## GLU_T0 GLU_T0 GLU_T0 integer dataDesc
## INS_T0 INS_T0 INS_T0 numeric dataDesc
## HOMA_T0 HOMA_T0 HOMA_T0 numeric dataDesc
## HBA1C_T0 HBA1C_T0 HBA1C_T0 numeric dataDesc
## HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0 HBA1C.mmol.mol_T0 numeric dataDesc
## ... ... ... ... ...
## SM.C18.0_T5 SM.C18.0_T5 SM.C18.0_T5 numeric dataDesc
## SM.C18.1_T5 SM.C18.1_T5 SM.C18.1_T5 numeric dataDesc
## SM.C20.2_T5 SM.C20.2_T5 SM.C20.2_T5 numeric dataDesc
## SM.C24.0_T5 SM.C24.0_T5 SM.C24.0_T5 numeric dataDesc
## SM.C24.1_T5 SM.C24.1_T5 SM.C24.1_T5 numeric dataDesc# I les dades bàsiques dels pacients
rowData(seMA)## DataFrame with 39 rows and 9 columns
## SUBJECTS SURGERY AGE GENDER Group MEDDM_T0 MEDCOL_T0
## <integer> <character> <integer> <character> <integer> <integer> <integer>
## 1 1 by pass 27 F 1 0 0
## 2 2 by pass 19 F 2 0 0
## 3 3 by pass 42 F 1 0 0
## 4 4 by pass 37 F 2 0 0
## 5 5 tubular 42 F 1 0 0
## ... ... ... ... ... ... ... ...
## 35 35 tubular 39 M 2 0 0
## 36 36 tubular 35 M 1 0 0
## 37 37 by pass 46 M 2 0 0
## 38 38 tubular 41 M 1 0 0
## 39 39 by pass 26 M 1 0 0
## MEDINF_T0 MEDHTA_T0
## <integer> <integer>
## 1 0 1
## 2 0 0
## 3 0 0
## 4 0 0
## 5 0 0
## ... ... ...
## 35 0 1
## 36 0 0
## 37 1 0
## 38 0 0
## 39 0 05. Anàlisi exploratoria inicial de les dades
5.1. Descripció de les dades
Fins ara hem vist que les nostres dades tenen NA, el que pot suposar un problema. Anem a veure també si la variabilitat de rangs és molt gran´i ens cal normalitzar les dades. Fem un summary a més per veure com varien els estadístics bàsics. Si ho fem amb tot l’arxiu no s’arriba a apreciar la sortida, així que en fem uns quants
summary(assay(seMA)[,1:150])## GLU_T0 INS_T0 HOMA_T0 HBA1C_T0
## Min. : 71.0 Min. : 3.40 Min. : 0.760 Min. :5.100
## 1st Qu.: 91.0 1st Qu.:11.85 1st Qu.: 2.435 1st Qu.:5.400
## Median :103.0 Median :16.00 Median : 4.210 Median :5.600
## Mean :106.5 Mean :17.60 Mean : 4.890 Mean :5.592
## 3rd Qu.:109.5 3rd Qu.:21.15 3rd Qu.: 5.720 3rd Qu.:5.800
## Max. :263.0 Max. :43.00 Max. :13.600 Max. :6.400
## NA's :15
## HBA1C.mmol.mol_T0 PESO_T0 bmi_T0 CC_T0
## Min. :32.23 Min. : 84.0 Min. :29.80 Min. :0.7000
## 1st Qu.:35.51 1st Qu.:119.5 1st Qu.:44.40 1st Qu.:0.9000
## Median :37.69 Median :135.0 Median :48.80 Median :0.9000
## Mean :37.60 Mean :140.0 Mean :50.52 Mean :0.9343
## 3rd Qu.:39.88 3rd Qu.:155.0 3rd Qu.:55.35 3rd Qu.:1.0000
## Max. :46.44 Max. :200.0 Max. :68.60 Max. :1.7000
## NA's :15 NA's :4
## CINT_T0 CAD_T0 TAD_T0 TAS_T0
## Min. : 90.0 Min. : 85.0 Min. : 60.00 Min. :111.0
## 1st Qu.:122.5 1st Qu.:136.0 1st Qu.: 74.50 1st Qu.:121.0
## Median :133.0 Median :148.0 Median : 83.00 Median :128.0
## Mean :135.7 Mean :147.1 Mean : 83.58 Mean :133.5
## 3rd Qu.:147.5 3rd Qu.:158.5 3rd Qu.: 90.00 3rd Qu.:144.0
## Max. :186.0 Max. :182.0 Max. :125.00 Max. :180.0
## NA's :4 NA's :4 NA's :8 NA's :8
## TG_T0 COL_T0 LDL_T0 HDL_T0
## Min. : 30.0 Min. :102.0 Min. : 24.0 Min. : 11.00
## 1st Qu.: 84.0 1st Qu.:180.5 1st Qu.:100.3 1st Qu.: 39.25
## Median :118.0 Median :207.0 Median :130.0 Median : 47.00
## Mean :129.1 Mean :206.6 Mean :128.2 Mean : 49.97
## 3rd Qu.:151.0 3rd Qu.:236.0 3rd Qu.:158.8 3rd Qu.: 59.50
## Max. :268.0 Max. :295.0 Max. :191.0 Max. :107.00
## NA's :1 NA's :1
## VLDL_T0 PCR_T0 LEP_T0 ADIPO_T0
## Min. : 6.00 Min. : 0.00 Min. : 27.00 Min. : 1.720
## 1st Qu.:16.80 1st Qu.: 3.51 1st Qu.: 49.25 1st Qu.: 4.700
## Median :23.60 Median : 8.25 Median : 67.20 Median : 7.460
## Mean :25.81 Mean :10.13 Mean : 78.33 Mean : 7.702
## 3rd Qu.:30.20 3rd Qu.:13.90 3rd Qu.: 98.25 3rd Qu.: 8.590
## Max. :53.60 Max. :29.80 Max. :155.00 Max. :17.100
## NA's :14 NA's :13 NA's :14
## GOT_T0 GPT_T0 GGT_T0 URICO_T0
## Min. :11.0 Min. : 11.00 Min. :12.00 Min. :2.700
## 1st Qu.:15.0 1st Qu.: 31.00 1st Qu.:20.00 1st Qu.:4.700
## Median :20.0 Median : 40.00 Median :26.00 Median :5.500
## Mean :23.9 Mean : 44.54 Mean :31.41 Mean :5.501
## 3rd Qu.:25.0 3rd Qu.: 48.50 3rd Qu.:37.00 3rd Qu.:6.200
## Max. :83.0 Max. :157.00 Max. :86.00 Max. :8.600
## NA's :2 NA's :2
## CREAT_T0 UREA_T0 HIERRO_T0 TRANSF_T0
## Min. :0.5000 Min. :14.00 Min. : 13.00 Min. :159.0
## 1st Qu.:0.7000 1st Qu.:24.00 1st Qu.: 50.00 1st Qu.:236.5
## Median :0.8000 Median :29.00 Median : 69.00 Median :268.5
## Mean :0.7923 Mean :31.38 Mean : 75.61 Mean :262.9
## 3rd Qu.:0.9000 3rd Qu.:38.00 3rd Qu.: 92.25 3rd Qu.:289.8
## Max. :1.2000 Max. :56.00 Max. :166.00 Max. :374.0
## NA's :1 NA's :9
## FERR_T0 Ile_T0 Leu_T0 Val_T0
## Min. : 11.10 Min. : 53.50 Min. : 90.1 Min. :183.0
## 1st Qu.: 25.00 1st Qu.: 83.55 1st Qu.:150.5 1st Qu.:256.0
## Median : 49.00 Median : 91.70 Median :183.0 Median :311.0
## Mean : 77.06 Mean : 98.98 Mean :185.2 Mean :318.4
## 3rd Qu.: 97.00 3rd Qu.:116.00 3rd Qu.:217.0 3rd Qu.:369.5
## Max. :372.00 Max. :150.00 Max. :281.0 Max. :508.0
## NA's :2
## Ala_T0 Pro_T0 Gly_T0 Ser_T0
## Min. :194.0 Min. :123.0 Min. :153.0 Min. : 94.5
## 1st Qu.:414.0 1st Qu.:164.5 1st Qu.:227.5 1st Qu.:133.5
## Median :459.0 Median :222.0 Median :270.0 Median :159.0
## Mean :471.9 Mean :234.6 Mean :291.1 Mean :161.4
## 3rd Qu.:543.0 3rd Qu.:257.5 3rd Qu.:311.5 3rd Qu.:180.0
## Max. :907.0 Max. :592.0 Max. :586.0 Max. :310.0
##
## Trp_T0 Phe_T0 Met_T0 Orn_T0
## Min. : 41.00 Min. : 48.40 Min. :-99.00 Min. : 39.6
## 1st Qu.: 52.15 1st Qu.: 70.60 1st Qu.: 23.25 1st Qu.: 74.6
## Median : 62.30 Median : 87.30 Median : 28.30 Median :103.0
## Mean : 67.22 Mean : 87.48 Mean : 23.08 Mean :102.4
## 3rd Qu.: 76.95 3rd Qu.:102.00 3rd Qu.: 33.30 3rd Qu.:128.5
## Max. :123.00 Max. :139.00 Max. : 53.00 Max. :195.0
##
## Arg_T0 His_T0 Asn_T0 Asp_T0
## Min. : 90.7 Min. : 70.50 Min. :27.30 Min. : 7.10
## 1st Qu.:120.5 1st Qu.: 80.65 1st Qu.:39.55 1st Qu.:15.65
## Median :143.0 Median : 94.40 Median :47.40 Median :20.50
## Mean :148.5 Mean : 97.68 Mean :48.81 Mean :23.12
## 3rd Qu.:167.5 3rd Qu.:108.00 3rd Qu.:56.00 3rd Qu.:27.85
## Max. :254.0 Max. :167.00 Max. :82.10 Max. :59.30
##
## Glu_T0 Gln_T0 Cit_T0 Tyr_T0
## Min. : 16.90 Min. : 241.0 Min. :12.00 Min. : 49.30
## 1st Qu.: 51.70 1st Qu.: 628.0 1st Qu.:26.25 1st Qu.: 71.65
## Median : 66.40 Median : 713.0 Median :30.30 Median : 89.00
## Mean : 84.68 Mean : 749.9 Mean :32.76 Mean : 92.46
## 3rd Qu.: 86.25 3rd Qu.: 872.5 3rd Qu.:38.35 3rd Qu.:108.00
## Max. :351.00 Max. :1320.0 Max. :59.50 Max. :162.00
##
## Thr_T0 Lys_T0 Creatinine_T0 Kynurenine_T0
## Min. : 67.5 Min. :266.0 Min. : 39.10 Min. :1.610
## 1st Qu.:112.0 1st Qu.:316.5 1st Qu.: 65.85 1st Qu.:2.540
## Median :144.0 Median :378.0 Median : 78.40 Median :3.160
## Mean :151.5 Mean :381.8 Mean : 80.43 Mean :3.303
## 3rd Qu.:177.5 3rd Qu.:434.5 3rd Qu.: 99.20 3rd Qu.:3.775
## Max. :286.0 Max. :562.0 Max. :115.00 Max. :6.510
##
## Putrescine_T0 Sarcosine_T0 Serotonin_T0 Taurine_T0
## Min. :-99.0000 Min. : 2.050 Min. :-99.0000 Min. : 41.00
## 1st Qu.: 0.1295 1st Qu.: 5.895 1st Qu.: 0.3565 1st Qu.: 78.55
## Median : 0.2120 Median : 7.700 Median : 0.6500 Median :107.00
## Mean :-12.7355 Mean : 8.648 Mean : -9.5029 Mean :108.77
## 3rd Qu.: 0.2670 3rd Qu.:12.200 3rd Qu.: 0.9180 3rd Qu.:132.50
## Max. : 0.3660 Max. :15.700 Max. : 1.8100 Max. :181.00
##
## SDMA_T0 C0_T0 C2_T0 C3.OH_T0
## Min. :0.820 Min. :21.60 Min. : 0.360 Min. :0.1500
## 1st Qu.:1.115 1st Qu.:36.00 1st Qu.: 5.215 1st Qu.:0.2100
## Median :1.290 Median :43.30 Median : 7.270 Median :0.2400
## Mean :1.317 Mean :45.60 Mean : 7.762 Mean :0.2474
## 3rd Qu.:1.535 3rd Qu.:52.05 3rd Qu.: 9.200 3rd Qu.:0.2800
## Max. :1.940 Max. :79.30 Max. :19.500 Max. :0.3700
##
## C6..C4.1.DC._T0 C5.DC..C6.OH._T0 C7.DC_T0 C8_T0
## Min. :-99.000 Min. :-9.0000 Min. :-9.0000 Min. :0.3230
## 1st Qu.: -9.000 1st Qu.: 0.0410 1st Qu.: 0.0395 1st Qu.:0.4385
## Median : 0.094 Median : 0.0490 Median : 0.0470 Median :0.5190
## Mean :-14.232 Mean :-1.1096 Mean :-1.1098 Mean :0.5419
## 3rd Qu.: 0.118 3rd Qu.: 0.0565 3rd Qu.: 0.0555 3rd Qu.:0.6235
## Max. : 0.201 Max. : 0.0780 Max. : 0.0760 Max. :0.8710
##
## C10_T0 C10.1_T0 C10.2_T0 C14.1_T0
## Min. :0.2500 Min. :0.1300 Min. :0.1000 Min. :0.0900
## 1st Qu.:0.4200 1st Qu.:0.1900 1st Qu.:0.1300 1st Qu.:0.1450
## Median :0.5200 Median :0.2300 Median :0.1500 Median :0.1900
## Mean :0.5274 Mean :0.2482 Mean :0.1621 Mean :0.1944
## 3rd Qu.:0.6350 3rd Qu.:0.3050 3rd Qu.:0.1850 3rd Qu.:0.2450
## Max. :0.9300 Max. :0.4200 Max. :0.2600 Max. :0.3000
##
## C14.2_T0 C16.1_T0 C16.2_T0 C16.2.OH_T0
## Min. :0.0600 Min. :0.0600 Min. :0.03000 Min. :0.00000
## 1st Qu.:0.1000 1st Qu.:0.0900 1st Qu.:0.03000 1st Qu.:0.04000
## Median :0.1200 Median :0.1000 Median :0.04000 Median :0.04000
## Mean :0.1244 Mean :0.1126 Mean :0.04487 Mean :0.04385
## 3rd Qu.:0.1400 3rd Qu.:0.1300 3rd Qu.:0.05000 3rd Qu.:0.05500
## Max. :0.2100 Max. :0.1900 Max. :0.08000 Max. :0.07000
##
## C18.1_T0 C18.1.OH_T0 C18.2_T0 lysoPC.a.C16.0_T0
## Min. :0.0700 Min. :0.03000 Min. :0.0600 Min. : 72.3
## 1st Qu.:0.1200 1st Qu.:0.04000 1st Qu.:0.0900 1st Qu.:118.5
## Median :0.1600 Median :0.04000 Median :0.1100 Median :144.0
## Mean :0.1703 Mean :0.04615 Mean :0.1074 Mean :151.7
## 3rd Qu.:0.2150 3rd Qu.:0.05000 3rd Qu.:0.1300 3rd Qu.:174.0
## Max. :0.2900 Max. :0.07000 Max. :0.1700 Max. :308.0
##
## lysoPC.a.C16.1_T0 lysoPC.a.C17.0_T0 lysoPC.a.C18.0_T0 lysoPC.a.C18.1_T0
## Min. :1.940 Min. :0.790 Min. : 14.30 Min. :12.70
## 1st Qu.:2.870 1st Qu.:1.445 1st Qu.: 34.05 1st Qu.:22.25
## Median :3.810 Median :2.110 Median : 45.20 Median :28.80
## Mean :4.283 Mean :2.101 Mean : 50.51 Mean :32.32
## 3rd Qu.:5.500 3rd Qu.:2.425 3rd Qu.: 60.70 3rd Qu.:40.55
## Max. :9.890 Max. :4.340 Max. :120.00 Max. :58.20
##
## lysoPC.a.C18.2_T0 lysoPC.a.C20.3_T0 lysoPC.a.C20.4_T0 lysoPC.a.C24.0_T0
## Min. : 19.10 Min. :1.190 Min. : 4.21 Min. :0.2400
## 1st Qu.: 34.75 1st Qu.:2.940 1st Qu.: 7.50 1st Qu.:0.3500
## Median : 39.90 Median :4.090 Median :10.50 Median :0.4600
## Mean : 43.82 Mean :4.373 Mean :10.77 Mean :0.4974
## 3rd Qu.: 50.75 3rd Qu.:5.335 3rd Qu.:13.55 3rd Qu.:0.5550
## Max. :109.00 Max. :9.410 Max. :19.60 Max. :0.9200
##
## lysoPC.a.C26.0_T0 lysoPC.a.C26.1_T0 lysoPC.a.C28.0_T0 lysoPC.a.C28.1_T0
## Min. :-9.0000 Min. :0.1200 Min. :-9.0000 Min. :0.2400
## 1st Qu.: 0.3100 1st Qu.:0.2600 1st Qu.: 0.2650 1st Qu.:0.3800
## Median : 0.4200 Median :0.3300 Median : 0.3400 Median :0.4600
## Mean : 0.2841 Mean :0.3408 Mean :-0.7536 Mean :0.5238
## 3rd Qu.: 0.5050 3rd Qu.:0.4150 3rd Qu.: 0.4100 3rd Qu.:0.5900
## Max. : 2.1300 Max. :0.6600 Max. : 1.7200 Max. :1.5000
##
## PC.aa.C24.0_T0 PC.aa.C28.1_T0 PC.aa.C30.0_T0 PC.aa.C32.0_T0
## Min. :-9.000 Min. :1.970 Min. :0.630 Min. : 5.360
## 1st Qu.: 0.145 1st Qu.:2.380 1st Qu.:1.420 1st Qu.: 8.525
## Median : 0.180 Median :2.910 Median :1.710 Median :10.200
## Mean :-1.650 Mean :3.014 Mean :1.895 Mean :10.695
## 3rd Qu.: 0.250 3rd Qu.:3.640 3rd Qu.:2.305 3rd Qu.:12.100
## Max. : 0.780 Max. :4.770 Max. :3.520 Max. :17.300
##
## PC.aa.C32.1_T0 PC.aa.C32.3_T0 PC.aa.C34.1_T0 PC.aa.C34.2_T0
## Min. : 2.64 Min. :0.1200 Min. : 50.60 Min. :154.0
## 1st Qu.: 7.11 1st Qu.:0.1750 1st Qu.: 99.75 1st Qu.:245.0
## Median :10.50 Median :0.2400 Median :136.00 Median :302.0
## Mean :11.77 Mean :0.2362 Mean :139.15 Mean :338.7
## 3rd Qu.:12.80 3rd Qu.:0.2800 3rd Qu.:161.00 3rd Qu.:389.5
## Max. :29.60 Max. :0.4400 Max. :310.00 Max. :904.0
##
## PC.aa.C34.3_T0 PC.aa.C34.4_T0 PC.aa.C36.0_T0 PC.aa.C36.1_T0
## Min. : 3.94 Min. :0.2000 Min. :0.610 Min. : 8.40
## 1st Qu.: 6.34 1st Qu.:0.3700 1st Qu.:1.030 1st Qu.:13.30
## Median : 9.73 Median :0.6300 Median :1.300 Median :15.70
## Mean :10.29 Mean :0.7015 Mean :1.568 Mean :18.32
## 3rd Qu.:11.00 3rd Qu.:0.9050 3rd Qu.:1.880 3rd Qu.:23.00
## Max. :24.40 Max. :1.8600 Max. :4.560 Max. :43.30
##
## PC.aa.C36.2_T0 PC.aa.C36.3_T0 PC.aa.C36.4_T0 PC.aa.C36.5_T0
## Min. : 60.6 Min. : 36.60 Min. : 40.10 Min. : 2.770
## 1st Qu.: 89.8 1st Qu.: 58.90 1st Qu.: 95.15 1st Qu.: 6.595
## Median :112.0 Median : 69.80 Median :120.00 Median : 9.200
## Mean :125.9 Mean : 78.45 Mean :120.26 Mean : 9.591
## 3rd Qu.:151.0 3rd Qu.: 91.20 3rd Qu.:149.50 3rd Qu.:11.750
## Max. :282.0 Max. :187.00 Max. :214.00 Max. :23.700
##
## PC.aa.C38.0_T0 PC.aa.C38.1_T0 PC.aa.C38.3_T0 PC.aa.C38.4_T0
## Min. :1.340 Min. :-9.000 Min. : 16.90 Min. : 34.20
## 1st Qu.:2.385 1st Qu.: 0.910 1st Qu.: 29.15 1st Qu.: 66.85
## Median :3.000 Median : 1.100 Median : 37.40 Median : 92.20
## Mean :3.258 Mean : 1.219 Mean : 41.54 Mean : 92.36
## 3rd Qu.:3.960 3rd Qu.: 1.625 3rd Qu.: 51.25 3rd Qu.:111.50
## Max. :6.180 Max. : 6.230 Max. :110.00 Max. :164.00
##
## PC.aa.C38.5_T0 PC.aa.C38.6_T0 PC.aa.C40.1_T0 PC.aa.C40.2_T0
## Min. :11.20 Min. : 13.90 Min. :-9.000 Min. :0.1700
## 1st Qu.:20.55 1st Qu.: 43.90 1st Qu.: 0.335 1st Qu.:0.2300
## Median :29.50 Median : 56.70 Median : 0.460 Median :0.3400
## Mean :28.74 Mean : 62.95 Mean :-1.550 Mean :0.6377
## 3rd Qu.:36.75 3rd Qu.: 77.45 3rd Qu.: 0.565 3rd Qu.:0.4300
## Max. :47.70 Max. :128.00 Max. : 3.330 Max. :5.7700
##
## PC.aa.C40.3_T0 PC.aa.C40.4_T0 PC.aa.C40.5_T0 PC.aa.C40.6_T0
## Min. :0.370 Min. :1.080 Min. : 1.750 Min. : 5.39
## 1st Qu.:0.490 1st Qu.:1.860 1st Qu.: 3.680 1st Qu.:16.15
## Median :0.580 Median :2.500 Median : 4.910 Median :19.50
## Mean :0.871 Mean :2.777 Mean : 5.178 Mean :22.21
## 3rd Qu.:0.780 3rd Qu.:3.385 3rd Qu.: 6.185 3rd Qu.:29.65
## Max. :4.820 Max. :5.970 Max. :11.100 Max. :41.10
##
## PC.aa.C42.0_T0 PC.aa.C42.1_T0 PC.aa.C42.2_T0 PC.aa.C42.4_T0
## Min. :0.3700 Min. :0.2000 Min. :0.1600 Min. :0.1100
## 1st Qu.:0.5600 1st Qu.:0.2750 1st Qu.:0.2150 1st Qu.:0.1800
## Median :0.6800 Median :0.3500 Median :0.2800 Median :0.2200
## Mean :0.7562 Mean :0.4087 Mean :0.4064 Mean :0.3379
## 3rd Qu.:0.8700 3rd Qu.:0.4250 3rd Qu.:0.3300 3rd Qu.:0.2450
## Max. :1.7400 Max. :1.3800 Max. :2.3100 Max. :2.6100
##
## PC.aa.C42.5_T0 PC.aa.C42.6_T0 PC.ae.C30.0_T0 PC.ae.C32.1_T0
## Min. :0.1300 Min. :-9.00000 Min. :0.2100 Min. :1.220
## 1st Qu.:0.2600 1st Qu.: 0.27500 1st Qu.:0.2700 1st Qu.:1.675
## Median :0.3200 Median : 0.34000 Median :0.3300 Median :2.160
## Mean :0.3818 Mean :-0.08128 Mean :0.3262 Mean :2.219
## 3rd Qu.:0.4000 3rd Qu.: 0.42500 3rd Qu.:0.3600 3rd Qu.:2.625
## Max. :1.4400 Max. : 1.09000 Max. :0.5000 Max. :4.120
##
## PC.ae.C32.2_T0 PC.ae.C34.0_T0 PC.ae.C34.1_T0 PC.ae.C34.2_T0
## Min. :0.3500 Min. :0.250 Min. :2.760 Min. : 3.030
## 1st Qu.:0.5450 1st Qu.:0.390 1st Qu.:4.135 1st Qu.: 5.310
## Median :0.6700 Median :0.470 Median :4.850 Median : 6.170
## Mean :0.6997 Mean :0.511 Mean :5.147 Mean : 7.382
## 3rd Qu.:0.8300 3rd Qu.:0.630 3rd Qu.:6.395 3rd Qu.: 8.590
## Max. :1.2000 Max. :0.840 Max. :9.350 Max. :19.000
##
## PC.ae.C34.3_T0 PC.ae.C36.0_T0 PC.ae.C36.1_T0 PC.ae.C36.2_T0
## Min. : 1.450 Min. :0.470 Min. : 1.510 Min. : 3.230
## 1st Qu.: 3.285 1st Qu.:0.760 1st Qu.: 2.310 1st Qu.: 4.390
## Median : 4.140 Median :0.940 Median : 3.120 Median : 5.210
## Mean : 4.581 Mean :1.008 Mean : 3.922 Mean : 5.852
## 3rd Qu.: 5.030 3rd Qu.:1.135 3rd Qu.: 3.695 3rd Qu.: 6.965
## Max. :10.100 Max. :1.980 Max. :18.200 Max. :10.800
##
## PC.ae.C36.3_T0 PC.ae.C36.4_T0 PC.ae.C36.5_T0 PC.ae.C38.0_T0
## Min. : 1.660 Min. : 2.180 Min. : 1.760 Min. :0.490
## 1st Qu.: 2.710 1st Qu.: 6.490 1st Qu.: 4.950 1st Qu.:1.265
## Median : 3.120 Median : 7.940 Median : 6.240 Median :1.630
## Mean : 3.812 Mean : 8.826 Mean : 6.642 Mean :1.623
## 3rd Qu.: 4.610 3rd Qu.:10.850 3rd Qu.: 8.215 3rd Qu.:1.945
## Max. :11.000 Max. :20.100 Max. :13.100 Max. :2.960
##
## PC.ae.C38.2_T0 PC.ae.C38.3_T0 PC.ae.C38.4_T0 PC.ae.C38.5_T0
## Min. : 0.350 Min. : 0.830 Min. : 3.100 Min. : 3.370
## 1st Qu.: 1.195 1st Qu.: 1.250 1st Qu.: 4.440 1st Qu.: 7.470
## Median : 1.580 Median : 1.530 Median : 5.480 Median : 8.610
## Mean : 2.752 Mean : 2.235 Mean : 5.729 Mean : 9.477
## 3rd Qu.: 2.115 3rd Qu.: 1.990 3rd Qu.: 6.425 3rd Qu.:10.500
## Max. :25.500 Max. :11.200 Max. :11.100 Max. :19.200
##
## PC.ae.C38.6_T0 PC.ae.C40.1_T0 PC.ae.C40.2_T0 PC.ae.C40.3_T0
## Min. :1.380 Min. :0.450 Min. :0.620 Min. : 0.560
## 1st Qu.:2.715 1st Qu.:0.895 1st Qu.:0.965 1st Qu.: 0.740
## Median :3.740 Median :1.160 Median :1.170 Median : 0.880
## Mean :3.995 Mean :1.373 Mean :1.557 Mean : 1.574
## 3rd Qu.:4.915 3rd Qu.:1.570 3rd Qu.:1.390 3rd Qu.: 1.160
## Max. :7.690 Max. :4.540 Max. :8.440 Max. :11.400
##
## PC.ae.C40.4_T0 PC.ae.C40.5_T0 PC.ae.C40.6_T0 PC.ae.C42.1_T0
## Min. :1.020 Min. :1.050 Min. :1.340 Min. :0.2100
## 1st Qu.:1.645 1st Qu.:1.570 1st Qu.:1.700 1st Qu.:0.3600
## Median :1.940 Median :1.790 Median :2.200 Median :0.4300
## Mean :2.380 Mean :2.317 Mean :2.309 Mean :0.6195
## 3rd Qu.:2.610 3rd Qu.:2.385 3rd Qu.:3.035 3rd Qu.:0.5650
## Max. :7.970 Max. :8.690 Max. :3.540 Max. :3.4000
##
## PC.ae.C42.2_T0 PC.ae.C42.3_T0
## Min. :0.2900 Min. :0.4600
## 1st Qu.:0.3800 1st Qu.:0.6050
## Median :0.4700 Median :0.7900
## Mean :0.6236 Mean :0.9569
## 3rd Qu.:0.6100 3rd Qu.:0.9450
## Max. :2.8200 Max. :4.1900
## Veiem que la variabilitat en els rangs és molt elevada i, per tant, caldrà normalitzar les dades. Recordem també que tenim un nombre de NAs força elevat.
5.2. Preprocessat
Amb el que hem pogut veure fins aquó de les dades que tenim és que ens calen dos procesos per poder començar els anàlisi multivariants:
- Imputar els missing values
- Normalitzar les dades
Això ho podem fer amb POMA que al mateix temps ens permet fer algun boxplot
# primer instal·lem el paquet i les llibreries
# BiocManager::install("POMA") # Això només el primer cop per instal·lar el paquet
library(POMA)## Welcome to POMA!
## Version 1.16.0
## POMAShiny app: https://github.com/pcastellanoescuder/POMAShinylibrary(ggtext)## Warning: package 'ggtext' was built under R version 4.4.3library(magrittr)##
## Attaching package: 'magrittr'## The following object is masked from 'package:GenomicRanges':
##
## subtractAtaquem primer la imputació.
Abans de fer-la cal dir que no podem imputar NA en columnes on no tenim cap valor. Per tant, mirem si hi ha alguna columna que no tingui cap valor i l’eliminem.
# Busquem columnes amb tot NAs
eliminats = c()
for (i in 1:685)
if (sum(is.na(assay(seMA)[,i])) == 39)
{print((paste(i, sum(is.na(assay(seMA)[,i])))))
eliminats = c(eliminats, i)}## [1] "248 39"Eliminem per tant, la columna 248
seMAclean <- seMA[,-eliminats]I fem la imputació dels NA utilitzant el knn que és possiblement el mètode més robust per fer-ho
seMAimputed <- seMAclean %>%
PomaImpute(method = "knn", zeros_as_na = FALSE, remove_na = FALSE, cutoff = 20)## -39 features removed.Després comprovem que no tenim NAs
sum(is.na(assay(seMAimputed)))## [1] 0Doncs ara, ha podem normalitzar les dades. D’entre els mètodes que es poden utilitzar hem rebutjat els logaritmes perquè amb les dades que tenim ens generen NAs, ek mix_max perquè genera molta variabilitat en les dades en el nostre cas i el box_cox perquè no funciona amb la matriu que tenim.
Ens queden els dos mètodes d’escalat i el auto_scaling és el que dona el gràfic més homogeni. Així que ens quedem amb aquest
# Ensenyem el resultat de min_max per veure que les funcions de densitat són molt variables
seMAnormalized <- seMAimputed %>%
PomaNorm(method = "min_max")
PomaDensity(seMAnormalized, x = "features")
# Ensenyem el resultat de min_max per veure que les funcions de densitat són molt variables
seMAnormalized <- seMAimputed %>%
PomaNorm(method = "auto_scaling")
PomaDensity(seMAnormalized, x = "features")
Sembla que hi ha algun outlier, però crec que no és preocupant
5.4. Analisi univariant
L’anàlisi univariant no té massa sentit amb una matriu tant gran de dades, però per provar alguna cosa, podem dir que fer alguns histogrames no està de mas. Farem 9 de les variables per veure una mica com es distribueixen després del preprocessament
opt <- par(mfrow=c(3,3))
for (i in 1:9)
hist(assay(seMAnormalized)[,i],
xlab = colData(seMAnormalized)[i,2],
main = colData(seMAnormalized)[i,2])
par(opt)Podem apreciar que les distribucions no són molt homogenies, el que potser implica poques correlacions. Veurem més endavant
6. Reducció de les dimensions
Un pas important ara que hem vist com són les variables pot ser fer un Anàlisi de Components Principals (PCA)). Com que tenim els NAs eliminats i les dades normalitzades, podem fer-lo sense problemes addicionals.
PCAseMA <- prcomp(assay(seMAnormalized), scale. = TRUE)
PCAseMA## Standard deviations (1, .., p=39):
## [1] 1.893256e+01 7.377935e+00 5.806778e+00 5.366514e+00 5.212884e+00
## [6] 4.421286e+00 4.032098e+00 3.610802e+00 3.464758e+00 2.993985e+00
## [11] 2.905096e+00 2.840228e+00 2.671005e+00 2.633563e+00 2.591891e+00
## [16] 2.550440e+00 2.438817e+00 2.282599e+00 2.222872e+00 2.118927e+00
## [21] 2.067725e+00 2.042961e+00 1.985076e+00 1.889037e+00 1.853185e+00
## [26] 1.802430e+00 1.759200e+00 1.735222e+00 1.711374e+00 1.624513e+00
## [31] 1.531975e+00 1.494274e+00 1.382320e+00 1.374211e+00 1.328333e+00
## [36] 1.224837e+00 1.109147e+00 1.021286e+00 1.161219e-14
##
## Rotation (n x k) = (685 x 39):
## PC1 PC2 PC3 PC4
## GLU_T0 -1.199624e-02 4.941264e-02 -2.319322e-02 -1.078391e-02
## INS_T0 -3.040036e-02 5.672071e-02 -2.721737e-02 2.233584e-02
## HOMA_T0 -4.080096e-02 3.104342e-02 -2.125132e-02 7.222602e-03
## HBA1C_T0 -4.651415e-02 -1.834343e-02 2.008314e-02 -5.565033e-04
## HBA1C.mmol.mol_T0 3.552732e-02 -9.188496e-03 2.104319e-02 4.572940e-04
## PESO_T0 -2.326499e-02 8.125680e-02 -3.630520e-02 -3.611425e-03
## bmi_T0 -2.471270e-02 8.087699e-02 -3.633006e-02 1.303281e-02
## CC_T0 -5.244727e-02 -1.569056e-03 6.832376e-03 6.712868e-03
## CINT_T0 -2.108588e-02 1.005267e-01 -1.260106e-02 2.898376e-02
## CAD_T0 -1.094508e-02 1.031612e-01 -1.546234e-02 -6.292826e-03
## TAD_T0 3.368663e-02 -5.542617e-03 1.880689e-02 -1.076498e-02
## TAS_T0 4.155077e-02 -5.256121e-04 3.309474e-03 -4.469568e-03
## TG_T0 4.626877e-03 2.775474e-02 -5.204236e-02 5.830628e-02
## COL_T0 -3.209452e-03 4.890035e-02 -1.392578e-02 2.888548e-02
## LDL_T0 -9.495424e-03 6.748697e-02 -1.252003e-02 2.204182e-02
## HDL_T0 6.530946e-04 -3.647308e-02 2.226752e-02 -1.236797e-02
## VLDL_T0 -4.486175e-03 2.630072e-02 -5.128724e-02 5.894473e-02
## PCR_T0 -1.594345e-02 -2.534249e-02 2.709684e-02 -1.312719e-02
## LEP_T0 -2.977204e-02 5.974349e-02 -1.459339e-02 5.927173e-03
## ADIPO_T0 -2.157399e-02 5.445112e-03 -1.229830e-02 -2.448064e-02
## GOT_T0 -1.097243e-02 3.930316e-03 3.068829e-02 3.609539e-03
## GPT_T0 -1.042910e-02 6.848081e-03 -1.324231e-02 -8.294370e-03
## GGT_T0 -2.106519e-02 5.718606e-02 -4.429951e-02 4.709703e-02
## URICO_T0 -4.690040e-02 3.257911e-02 -1.050633e-02 2.145387e-02
## CREAT_T0 -5.238177e-02 -4.462782e-03 7.125217e-03 3.583363e-04
## UREA_T0 -1.102555e-02 4.186594e-02 -8.738753e-03 3.110859e-02
## HIERRO_T0 -3.876584e-03 4.665753e-02 -5.411954e-03 2.833490e-02
## TRANSF_T0 3.990148e-02 -6.735974e-03 1.411681e-02 2.756888e-02
## FERR_T0 1.100355e-02 2.202379e-02 1.604286e-02 1.859058e-03
## Ile_T0 -9.979157e-03 4.347839e-02 -8.025407e-02 3.102797e-02
## Leu_T0 -1.901120e-03 3.243955e-02 -8.925402e-02 2.524131e-02
## Val_T0 1.370998e-03 2.254413e-02 -9.141408e-02 3.520201e-02
## Ala_T0 -5.657694e-03 5.095690e-02 -1.196257e-01 2.891007e-02
## Pro_T0 -2.375758e-02 4.844247e-02 -8.208939e-02 -1.149389e-02
## Gly_T0 -1.004746e-02 3.877661e-02 -6.471853e-02 -2.918055e-02
## Ser_T0 -1.665486e-02 5.123520e-02 -7.174336e-02 -1.949394e-02
## Trp_T0 -1.706001e-02 1.060458e-02 -9.699474e-02 2.718742e-02
## Phe_T0 -8.719772e-03 4.965718e-02 -1.062346e-01 1.202598e-04
## Met_T0 2.364641e-02 -8.029138e-02 4.323907e-02 -2.661267e-02
## Orn_T0 -9.794162e-03 4.300912e-03 -8.253731e-02 2.358071e-02
## Arg_T0 -8.207693e-03 7.242484e-02 -9.691286e-02 5.283762e-02
## His_T0 -1.961687e-02 3.543715e-02 -1.080403e-01 -6.512983e-03
## Asn_T0 -2.278992e-02 -1.581569e-02 -2.588730e-02 -2.529066e-02
## Asp_T0 -2.454699e-02 7.611141e-02 -6.003059e-02 3.112978e-02
## Glu_T0 -1.891976e-02 9.132817e-02 -6.796917e-02 5.490545e-02
## Gln_T0 -6.384554e-03 -5.760449e-02 -2.247765e-02 -7.017922e-02
## Cit_T0 -3.067717e-02 4.560629e-02 -3.427953e-02 3.033582e-02
## Tyr_T0 -1.926940e-02 2.538624e-02 -1.016609e-01 1.033410e-02
## Thr_T0 -3.264978e-03 -2.056393e-02 -4.111030e-02 1.093298e-02
## Lys_T0 -6.434112e-03 1.624795e-02 -1.015303e-01 4.084040e-02
## Creatinine_T0 -1.030747e-02 5.069871e-02 -3.989496e-02 -1.454879e-03
## Kynurenine_T0 -4.960725e-02 -3.669416e-03 -2.642139e-02 -9.883789e-04
## Putrescine_T0 -7.308058e-03 -6.104151e-04 -1.309582e-02 5.102346e-03
## Sarcosine_T0 -3.160741e-02 4.123728e-02 -1.020420e-02 2.945476e-02
## Serotonin_T0 -7.413211e-03 -7.621286e-03 4.666980e-02 5.402820e-03
## Taurine_T0 -1.772370e-02 3.613755e-02 -3.522009e-02 1.739916e-02
## SDMA_T0 -5.241650e-02 -2.826580e-03 3.299265e-03 6.957672e-04
## C0_T0 -2.576613e-02 4.587907e-02 -8.069356e-02 4.560331e-02
## C2_T0 -2.218579e-02 -2.907379e-02 3.813234e-02 -2.346379e-02
## C3.OH_T0 -5.247407e-02 -8.697286e-03 6.063526e-03 1.223400e-03
## C6..C4.1.DC._T0 3.267974e-03 3.041575e-02 4.521626e-02 1.201054e-02
## C5.DC..C6.OH._T0 -3.565798e-02 -1.456302e-02 3.969868e-03 1.830535e-02
## C7.DC_T0 -3.495627e-02 -5.186282e-03 6.317214e-03 -5.121927e-03
## C8_T0 -5.250656e-02 -7.142245e-03 5.207529e-03 2.284466e-03
## C10_T0 -5.251524e-02 -5.433485e-03 3.792803e-03 2.205449e-03
## C10.1_T0 -5.249195e-02 -8.578609e-03 4.615177e-03 1.155361e-03
## C10.2_T0 -5.245744e-02 -8.645811e-03 6.548846e-03 1.100308e-03
## C14.1_T0 -5.249986e-02 -8.257121e-03 5.865208e-03 1.783103e-03
## C14.2_T0 -5.247850e-02 -8.609041e-03 6.262901e-03 1.412700e-03
## C16.1_T0 -5.248726e-02 -8.523857e-03 6.458853e-03 1.373352e-03
## C16.2_T0 -5.246910e-02 -9.095494e-03 6.594646e-03 1.459950e-03
## C16.2.OH_T0 -5.247213e-02 -9.103851e-03 6.569942e-03 1.380622e-03
## C18.1_T0 -5.253721e-02 -7.752416e-03 5.969628e-03 1.142369e-03
## C18.1.OH_T0 -5.246717e-02 -9.145540e-03 6.585084e-03 1.396145e-03
## C18.2_T0 -5.248329e-02 -8.754111e-03 6.588226e-03 1.652488e-03
## lysoPC.a.C16.0_T0 -1.888892e-02 7.119173e-02 -1.024627e-01 3.386555e-02
## lysoPC.a.C16.1_T0 -4.645715e-02 2.996157e-02 -5.568621e-02 1.882351e-02
## lysoPC.a.C17.0_T0 -5.085825e-02 1.727304e-02 -1.904967e-02 1.555739e-02
## lysoPC.a.C18.0_T0 -1.950736e-02 5.616350e-02 -1.097307e-01 3.486232e-02
## lysoPC.a.C18.1_T0 -2.845384e-02 5.606669e-02 -7.789242e-02 2.511448e-02
## lysoPC.a.C18.2_T0 -2.672044e-02 1.336755e-02 -8.544482e-02 9.233331e-03
## lysoPC.a.C20.3_T0 -4.491626e-02 2.014642e-03 -5.759618e-02 2.154599e-02
## lysoPC.a.C20.4_T0 -3.186501e-02 3.680045e-02 -4.321636e-02 1.251284e-02
## lysoPC.a.C24.0_T0 -5.259933e-02 -4.423072e-03 1.436010e-03 2.071438e-03
## lysoPC.a.C26.0_T0 -4.635546e-02 -8.375227e-04 -1.651850e-02 2.296390e-02
## lysoPC.a.C26.1_T0 -5.260177e-02 -4.112828e-03 3.559603e-03 7.598541e-04
## lysoPC.a.C28.0_T0 -3.820598e-02 -1.176691e-02 -3.463173e-02 1.541886e-02
## lysoPC.a.C28.1_T0 -5.268437e-02 9.811227e-04 -1.621543e-03 3.456510e-03
## PC.aa.C24.0_T0 -3.450394e-02 1.405759e-02 -1.144507e-02 -1.788179e-02
## PC.aa.C28.1_T0 -5.090210e-02 -5.572934e-03 -8.989270e-03 1.676002e-03
## PC.aa.C30.0_T0 -5.076110e-02 -1.062761e-02 -4.171637e-03 5.860590e-03
## PC.aa.C32.0_T0 -4.047902e-02 -1.049841e-02 -2.208971e-02 -5.985915e-03
## PC.aa.C32.1_T0 -2.933937e-02 -4.226707e-03 -5.208939e-02 1.485087e-02
## PC.aa.C32.3_T0 -5.254305e-02 -8.265740e-03 4.482921e-03 2.645503e-03
## PC.aa.C34.1_T0 -4.679961e-03 -2.399894e-03 -5.577084e-02 2.887736e-02
## PC.aa.C34.2_T0 -5.839240e-03 -5.785504e-02 -3.948971e-02 3.145463e-02
## PC.aa.C34.3_T0 -3.396562e-02 -2.782546e-02 -5.344318e-02 2.916803e-02
## PC.aa.C34.4_T0 -5.193914e-02 -1.288689e-02 -9.518723e-04 7.521392e-03
## PC.aa.C36.0_T0 -5.113143e-02 1.940279e-02 -1.720350e-02 1.913615e-02
## PC.aa.C36.1_T0 -2.407247e-02 -2.667213e-03 -7.121721e-02 5.948390e-02
## PC.aa.C36.2_T0 -8.060236e-03 -4.625739e-02 -6.466646e-02 3.938564e-02
## PC.aa.C36.3_T0 -6.934274e-03 -4.507168e-02 -5.754152e-02 4.404455e-02
## PC.aa.C36.4_T0 7.269459e-03 -1.944508e-02 -3.726738e-03 2.456261e-02
## PC.aa.C36.5_T0 -2.377410e-02 1.315630e-02 -1.724130e-02 5.942156e-02
## PC.aa.C38.0_T0 -4.909721e-02 1.107830e-02 -2.123144e-02 1.879520e-02
## PC.aa.C38.1_T0 -4.226607e-02 3.070666e-02 -3.542939e-04 3.360842e-02
## PC.aa.C38.3_T0 -7.449456e-03 -2.944195e-02 -8.810957e-02 4.505764e-02
## PC.aa.C38.4_T0 4.819443e-03 -1.588009e-02 -3.221724e-02 1.804556e-02
## PC.aa.C38.5_T0 -8.793357e-03 -1.005540e-02 -2.803464e-02 3.987593e-02
## PC.aa.C38.6_T0 3.682175e-03 -5.666075e-03 -2.843888e-03 1.717111e-02
## PC.aa.C40.1_T0 -3.532944e-02 -7.802958e-03 -5.990080e-02 3.450067e-02
## PC.aa.C40.2_T0 -4.948016e-02 2.974843e-02 -2.947529e-02 2.070395e-02
## PC.aa.C40.3_T0 -5.078606e-02 2.243592e-02 -2.445202e-02 1.596725e-02
## PC.aa.C40.4_T0 -4.967989e-02 1.463772e-02 -4.116538e-02 2.311102e-02
## PC.aa.C40.5_T0 -4.508810e-02 -1.838723e-02 -3.328628e-02 1.524805e-02
## PC.aa.C40.6_T0 -6.193391e-03 -4.759122e-03 -2.173514e-02 3.784442e-02
## PC.aa.C42.0_T0 -5.263114e-02 3.232547e-03 -4.267086e-03 5.772590e-03
## PC.aa.C42.1_T0 -5.270876e-02 1.840187e-03 -2.633491e-03 5.705166e-03
## PC.aa.C42.2_T0 -5.235307e-02 9.994660e-03 -1.034820e-02 9.934093e-03
## PC.aa.C42.4_T0 -5.233352e-02 7.367583e-03 -1.202856e-02 9.351755e-03
## PC.aa.C42.5_T0 -5.269167e-02 -1.287353e-03 -3.441852e-03 4.735824e-03
## PC.aa.C42.6_T0 -4.304304e-02 -4.360666e-03 -1.269944e-02 1.956059e-02
## PC.ae.C30.0_T0 -5.254257e-02 -7.763565e-03 3.942071e-03 1.377721e-03
## PC.ae.C32.1_T0 -5.134015e-02 -1.054594e-02 -4.191666e-03 -3.771758e-03
## PC.ae.C32.2_T0 -5.254671e-02 -7.489553e-03 4.855983e-04 2.477391e-03
## PC.ae.C34.0_T0 -5.252130e-02 -7.244882e-03 4.246375e-03 3.879746e-03
## PC.ae.C34.1_T0 -4.894199e-02 -1.066988e-02 -7.958685e-03 5.977845e-03
## PC.ae.C34.2_T0 -3.815767e-02 -3.850930e-02 -2.519837e-02 1.399627e-02
## PC.ae.C34.3_T0 -4.339116e-02 -3.679685e-02 -1.527740e-02 6.648265e-03
## PC.ae.C36.0_T0 -5.256366e-02 2.609808e-03 -5.873801e-03 8.648078e-03
## PC.ae.C36.1_T0 -3.954970e-02 6.158932e-02 -5.052192e-02 3.778079e-02
## PC.ae.C36.2_T0 -4.722815e-02 1.147999e-02 -1.985515e-02 2.980044e-02
## PC.ae.C36.3_T0 -4.564989e-02 -2.815843e-02 -1.852507e-02 1.615099e-02
## PC.ae.C36.4_T0 -3.142224e-02 -3.911879e-02 -2.895686e-02 1.854032e-02
## PC.ae.C36.5_T0 -3.810759e-02 -3.191308e-02 -1.404708e-02 1.430391e-02
## PC.ae.C38.0_T0 -5.176857e-02 -5.287911e-03 -5.684053e-03 1.273141e-02
## PC.ae.C38.2_T0 -3.518049e-02 5.861955e-02 -6.408075e-02 3.593753e-02
## PC.ae.C38.3_T0 -4.089493e-02 5.243691e-02 -5.363895e-02 5.026145e-02
## PC.ae.C38.4_T0 -4.569485e-02 2.625039e-03 -2.448249e-02 2.056411e-02
## PC.ae.C38.5_T0 -3.192526e-02 -2.723012e-02 -1.504464e-02 2.332015e-03
## PC.ae.C38.6_T0 -4.613645e-02 -2.173110e-02 -5.003642e-03 1.414507e-02
## PC.ae.C40.1_T0 -5.084815e-02 2.284226e-02 -2.106949e-02 1.964880e-02
## PC.ae.C40.2_T0 -4.710051e-02 3.631939e-02 -3.784293e-02 2.692484e-02
## PC.ae.C40.3_T0 -4.020022e-02 5.202573e-02 -5.975111e-02 4.330442e-02
## PC.ae.C40.4_T0 -4.713499e-02 3.459666e-02 -4.848859e-02 2.895913e-02
## PC.ae.C40.5_T0 -4.608866e-02 4.094891e-02 -4.734619e-02 3.106280e-02
## PC.ae.C40.6_T0 -5.133905e-02 -7.497071e-03 4.333479e-05 7.503292e-03
## PC.ae.C42.1_T0 -5.172954e-02 1.700410e-02 -1.623628e-02 1.361134e-02
## PC.ae.C42.2_T0 -5.214331e-02 1.293312e-02 -1.249491e-02 1.188298e-02
## PC.ae.C42.3_T0 -5.140818e-02 1.829603e-02 -1.933481e-02 1.482275e-02
## PC.ae.C42.4_T0 -5.233265e-02 5.381443e-03 -1.570495e-02 9.153817e-03
## PC.ae.C42.5_T0 -5.075374e-02 1.856278e-02 -2.889258e-02 1.420372e-02
## PC.ae.C44.3_T0 -5.262260e-02 2.564179e-03 -4.501264e-03 6.423447e-03
## PC.ae.C44.4_T0 -5.264653e-02 -3.518964e-03 -8.844004e-04 3.910610e-03
## PC.ae.C44.5_T0 -5.078459e-02 -1.029710e-02 2.150019e-03 -1.480206e-03
## PC.ae.C44.6_T0 -5.167694e-02 -1.145469e-02 -1.209864e-03 -4.265336e-04
## SM..OH..C14.1_T0 -4.928159e-02 -1.530486e-02 9.313234e-03 -5.387356e-03
## SM..OH..C16.1_T0 -5.181957e-02 -8.689912e-03 1.020446e-02 1.710025e-03
## SM..OH..C22.1_T0 -3.615453e-02 -4.026414e-02 6.899994e-03 1.878689e-02
## SM..OH..C22.2_T0 -4.666995e-02 3.342502e-03 -1.296481e-02 1.391046e-02
## SM..OH..C24.1_T0 -5.226009e-02 -1.048512e-02 8.167850e-03 2.521347e-03
## SM.C16.0_T0 -7.828120e-03 -8.261959e-03 -3.558635e-03 -1.574621e-02
## SM.C16.1_T0 -3.170526e-02 -2.404167e-02 -1.615961e-02 -1.583856e-02
## SM.C18.0_T0 -2.901498e-02 1.082833e-02 1.581796e-02 2.361674e-03
## SM.C18.1_T0 -3.905315e-02 -3.637680e-03 8.261195e-03 -6.774493e-03
## SM.C20.2_T0 -5.245883e-02 -9.913957e-03 6.340898e-03 1.655250e-03
## SM.C24.0_T0 -3.504443e-02 -1.304466e-02 -3.389091e-02 1.930640e-02
## SM.C24.1_T0 -1.898667e-02 1.945600e-02 5.773657e-03 3.296389e-03
## MEDDM_T2 -5.245502e-02 -9.564885e-03 6.632371e-03 1.080576e-03
## MEDCOL_T2 -5.245502e-02 -9.564885e-03 6.632371e-03 1.080576e-03
## MEDINF_T2 -5.211366e-02 -1.071897e-02 8.022690e-03 4.077391e-03
## MEDHTA_T2 -5.191703e-02 -6.650130e-03 4.399277e-04 8.783626e-03
## GLU_T2 3.825544e-02 4.252139e-03 8.247871e-03 6.010433e-03
## INS_T2 -4.434399e-04 -1.904866e-02 1.892014e-02 -5.602655e-02
## HOMA_T2 -3.988365e-02 -1.687539e-02 1.363804e-02 -2.900605e-02
## HBA1C_T2 -4.792830e-02 -1.739073e-02 2.556816e-02 -3.765267e-03
## HBA1C.mmol.mol_T2 3.171862e-02 -1.119653e-02 5.174481e-02 -1.201423e-02
## PESO_T2 3.380214e-02 -1.080327e-02 -2.174437e-02 -3.614014e-02
## bmi_T2 3.172695e-02 -1.218128e-02 -2.219040e-02 -1.703664e-02
## CC_T2 -5.216416e-02 -9.795423e-03 8.209750e-03 2.364884e-03
## CINT_T2 4.225017e-02 -1.881668e-03 -4.082745e-03 -4.780645e-03
## CAD_T2 4.179569e-02 -1.463169e-02 -1.059582e-02 -2.620972e-02
## TAD_T2 4.150739e-02 7.100272e-03 -2.455751e-02 2.022245e-02
## TAS_T2 4.103215e-02 8.194423e-03 -1.866632e-02 1.211508e-03
## TG_T2 2.816995e-02 -5.140429e-03 2.624929e-02 8.348114e-03
## COL_T2 3.435067e-02 -1.191990e-02 5.950666e-02 3.593478e-03
## LDL_T2 3.493637e-02 6.368421e-04 5.580306e-02 1.864162e-02
## HDL_T2 1.345175e-02 -2.688160e-02 6.069721e-02 -3.438750e-03
## VLDL_T2 9.435087e-03 -2.811919e-02 3.547613e-02 -1.640362e-02
## PCR_T2 -1.412898e-02 -7.153529e-04 4.185992e-02 -2.697978e-02
## LEP_T2 1.146354e-02 -1.097647e-02 1.987033e-02 2.800129e-03
## ADIPO_T2 -9.355925e-03 1.016337e-03 -1.348928e-02 -1.676050e-02
## GOT_T2 2.360281e-03 -4.586665e-02 1.356174e-02 1.720447e-02
## GPT_T2 7.162270e-03 -2.884920e-02 -5.487717e-03 1.160603e-02
## GGT_T2 7.795501e-03 -2.681696e-02 2.554680e-02 1.852152e-02
## URICO_T2 -3.060967e-02 -2.809284e-02 2.956216e-03 -3.039250e-02
## CREAT_T2 -5.200608e-02 -1.218551e-02 7.035255e-03 -3.953076e-03
## UREA_T2 1.408107e-02 1.329286e-02 7.416350e-02 -2.894384e-02
## HIERRO_T2 1.517783e-02 -1.184607e-02 1.936847e-02 6.521345e-02
## TRANSF_T2 4.199475e-02 -1.246983e-02 2.440201e-02 2.761878e-03
## FERR_T2 7.675456e-03 1.469931e-02 -8.725266e-03 -1.736711e-02
## Ile_T2 -8.621274e-03 5.497743e-02 -2.719281e-03 -1.001336e-01
## Leu_T2 -7.991628e-03 5.891425e-02 4.834765e-04 -1.001346e-01
## Val_T2 -1.093656e-02 6.777186e-02 1.628445e-02 -1.015320e-01
## Ala_T2 -1.674712e-02 7.820676e-02 3.684546e-02 -5.876309e-02
## Pro_T2 -1.612979e-02 6.755335e-02 1.536146e-02 -8.844213e-02
## Gly_T2 -5.530842e-03 3.553334e-02 4.204593e-02 -7.628765e-02
## Ser_T2 -3.100467e-03 4.105752e-02 2.107735e-02 -8.835778e-02
## Trp_T2 -2.766754e-03 6.757765e-02 7.508522e-02 -8.954113e-02
## Phe_T2 -5.692661e-03 6.578627e-02 2.704765e-02 -9.437132e-02
## Met_T2 -1.747946e-02 3.089153e-03 4.662582e-02 -1.477892e-02
## Orn_T2 -3.148348e-03 4.774206e-02 3.655536e-02 -7.391611e-02
## Arg_T2 -8.224978e-03 9.950650e-02 5.251903e-02 -3.832805e-02
## His_T2 -1.376341e-02 9.003043e-02 2.209472e-02 -8.717891e-02
## Asn_T2 -2.652617e-02 6.025220e-02 6.064235e-02 -7.983231e-02
## Asp_T2 -9.997523e-04 3.315654e-02 3.544431e-02 -6.710315e-03
## Glu_T2 7.175733e-03 6.425496e-02 -7.479546e-02 3.022789e-02
## Gln_T2 -1.947893e-02 3.329075e-02 8.014939e-02 -7.136711e-02
## Cit_T2 -2.384681e-02 6.593545e-02 5.819803e-02 -5.666937e-02
## Tyr_T2 -1.792655e-02 7.871440e-02 4.156426e-02 -6.984888e-02
## Thr_T2 -1.433721e-02 3.885229e-02 2.722568e-02 -8.101006e-02
## Lys_T2 -6.023937e-03 7.755619e-02 4.519433e-02 -8.510239e-02
## Creatinine_T2 -7.893733e-03 6.571092e-02 3.904550e-02 -8.615072e-02
## Kynurenine_T2 -5.067728e-02 4.045360e-03 2.062023e-02 -2.315684e-02
## Putrescine_T2 3.431822e-03 2.780524e-02 -1.475363e-02 9.083907e-03
## Sarcosine_T2 -2.618470e-02 3.965990e-02 4.400402e-02 -3.359136e-02
## Serotonin_T2 -1.023620e-02 9.753314e-03 -1.196136e-02 -3.510861e-02
## Taurine_T2 -1.174743e-02 3.227001e-02 9.268447e-03 -3.186203e-03
## SDMA_T2 -5.156382e-02 1.879322e-03 1.290757e-02 -1.335975e-02
## C0_T2 -1.308114e-02 7.750648e-02 4.646985e-02 -1.763247e-02
## C2_T2 -3.077317e-02 -1.270500e-02 1.518447e-04 -2.498897e-02
## C3.OH_T2 -5.246289e-02 -8.721361e-03 7.433831e-03 -4.104634e-04
## C6..C4.1.DC._T2 -8.794011e-05 1.910149e-02 -3.701148e-02 7.061459e-02
## C5.DC..C6.OH._T2 -3.966257e-02 -7.223369e-05 1.488706e-02 2.432386e-02
## C7.DC_T2 -3.945212e-02 -1.980068e-02 2.891609e-02 -2.036034e-02
## C8_T2 -5.247319e-02 -5.835348e-03 9.043459e-03 -1.731781e-03
## C10_T2 -5.246485e-02 -5.304002e-03 8.694260e-03 -3.987744e-03
## C10.1_T2 -5.247819e-02 -8.349250e-03 6.843062e-03 -1.389674e-03
## C10.2_T2 -5.247311e-02 -8.721554e-03 8.374141e-03 8.508383e-05
## C14.1_T2 -5.246604e-02 -8.142849e-03 7.353581e-03 1.867183e-04
## C14.2_T2 -5.244983e-02 -8.934934e-03 7.540346e-03 5.834426e-04
## C16.1_T2 -5.246639e-02 -8.892285e-03 7.453149e-03 9.577030e-04
## C16.2_T2 -5.246115e-02 -9.330009e-03 6.968043e-03 1.079576e-03
## C16.2.OH_T2 -5.246307e-02 -9.292363e-03 6.853309e-03 1.052735e-03
## C18.1_T2 -5.247788e-02 -8.059194e-03 7.173419e-03 -1.154825e-03
## C18.1.OH_T2 -5.245963e-02 -9.360578e-03 7.095768e-03 9.061943e-04
## C18.2_T2 -5.244010e-02 -9.203304e-03 7.137599e-03 3.176886e-04
## lysoPC.a.C14.0_T2 -2.281826e-02 -2.099876e-02 4.869040e-02 -6.003401e-02
## lysoPC.a.C16.0_T2 3.493555e-03 7.448962e-02 1.829048e-02 -6.285216e-02
## lysoPC.a.C16.1_T2 -4.670242e-02 2.390311e-02 2.526679e-02 -3.617971e-02
## lysoPC.a.C17.0_T2 -5.072213e-02 1.749478e-02 1.964668e-02 -1.388903e-02
## lysoPC.a.C18.0_T2 -5.873949e-03 9.003806e-02 4.289960e-02 -3.330789e-02
## lysoPC.a.C18.1_T2 -7.168029e-03 6.562473e-02 5.350483e-02 -8.218161e-02
## lysoPC.a.C18.2_T2 -1.281283e-02 5.720073e-02 6.436753e-02 -6.609383e-02
## lysoPC.a.C20.3_T2 -4.856328e-02 2.413333e-02 2.823329e-02 -1.929142e-02
## lysoPC.a.C20.4_T2 -3.083156e-02 3.708094e-02 2.702869e-02 -6.382399e-02
## lysoPC.a.C24.0_T2 -5.250876e-02 -5.785631e-03 7.645641e-03 8.490239e-04
## lysoPC.a.C26.0_T2 -3.694677e-02 -1.823682e-03 8.127999e-03 -2.731974e-02
## lysoPC.a.C26.1_T2 -5.242601e-02 -8.338033e-03 6.106086e-03 -1.056458e-03
## lysoPC.a.C28.0_T2 -2.936705e-02 1.280549e-02 1.984245e-02 -3.555226e-02
## lysoPC.a.C28.1_T2 -5.241746e-02 -4.941967e-03 6.137211e-03 -8.752074e-04
## PC.aa.C24.0_T2 -1.427309e-02 -3.239714e-02 2.729680e-02 -2.494807e-02
## PC.aa.C28.1_T2 -5.132681e-02 9.440831e-03 3.099406e-02 -1.031314e-02
## PC.aa.C30.0_T2 -5.202883e-02 -1.455034e-03 1.700220e-02 -8.123360e-03
## PC.aa.C32.0_T2 -3.869823e-02 2.687094e-02 5.608107e-02 -5.442115e-02
## PC.aa.C32.1_T2 -3.876949e-02 3.663324e-02 3.865157e-02 -3.515520e-02
## PC.aa.C32.3_T2 -5.253778e-02 -7.642949e-03 6.702165e-03 -4.443329e-04
## PC.aa.C34.1_T2 -6.871676e-03 6.605999e-02 9.276728e-02 -7.690553e-02
## PC.aa.C34.2_T2 -2.109368e-02 6.180995e-02 9.372387e-02 -4.502574e-02
## PC.aa.C34.3_T2 -3.948838e-02 4.385576e-02 5.840761e-02 -2.567210e-02
## PC.aa.C34.4_T2 -5.250617e-02 -4.972344e-03 1.066010e-02 -1.586721e-03
## PC.aa.C36.0_T2 -5.175205e-02 6.067581e-03 7.172530e-03 -6.574652e-03
## PC.aa.C36.1_T2 -2.360321e-02 8.036915e-02 7.265451e-02 -3.386197e-02
## PC.aa.C36.2_T2 -1.459649e-02 7.477894e-02 9.525628e-02 -1.698838e-02
## PC.aa.C36.3_T2 -1.460511e-02 7.605173e-02 8.745500e-02 -3.869726e-02
## PC.aa.C36.4_T2 -2.018011e-02 3.026035e-02 5.029445e-02 -5.499788e-02
## PC.aa.C36.5_T2 -2.966238e-02 3.767907e-02 4.615501e-02 -4.347601e-02
## PC.aa.C38.0_T2 -5.023731e-02 2.264437e-02 2.931214e-02 -1.909040e-02
## PC.aa.C38.1_T2 -4.530134e-02 2.682410e-02 -2.860314e-04 -2.944812e-02
## PC.aa.C38.3_T2 -2.349020e-02 8.168681e-02 7.646186e-02 -2.231953e-02
## PC.aa.C38.4_T2 -1.962151e-02 6.048277e-02 8.261177e-02 -5.319342e-02
## PC.aa.C38.5_T2 -2.422760e-02 5.609569e-02 8.694400e-02 -6.374079e-02
## PC.aa.C38.6_T2 -1.405830e-02 4.953124e-02 6.309218e-02 -3.780808e-02
## PC.aa.C40.1_T2 -2.775708e-02 3.940623e-02 7.435345e-03 -5.730204e-02
## PC.aa.C40.2_T2 -5.042860e-02 6.634111e-03 -1.657985e-02 7.106866e-03
## PC.aa.C40.3_T2 -5.124411e-02 4.023766e-03 -5.621997e-03 -1.139779e-03
## PC.aa.C40.4_T2 -5.049400e-02 2.448560e-02 1.043348e-02 -7.141418e-03
## PC.aa.C40.5_T2 -4.539757e-02 3.198962e-02 5.355546e-02 -2.436583e-02
## PC.aa.C40.6_T2 -2.352882e-02 6.759138e-02 6.843537e-02 -2.036261e-02
## PC.aa.C42.0_T2 -5.253554e-02 -3.916966e-03 5.710044e-03 -2.719226e-03
## PC.aa.C42.1_T2 -5.252381e-02 -5.140283e-03 5.328132e-03 -1.722765e-03
## PC.aa.C42.2_T2 -5.233557e-02 -2.056739e-03 -3.032401e-03 9.581801e-04
## PC.aa.C42.4_T2 -5.248732e-02 -2.398640e-03 -3.353148e-03 4.047450e-03
## PC.aa.C42.5_T2 -5.260377e-02 -4.255415e-03 4.630732e-03 2.678030e-04
## PC.aa.C42.6_T2 -4.149299e-02 -7.351144e-03 2.247671e-02 -1.793776e-02
## PC.ae.C30.0_T2 -3.866764e-02 3.953976e-03 1.315170e-02 -3.710400e-02
## PC.ae.C32.1_T2 -5.158453e-02 6.287398e-03 2.350916e-02 -1.888153e-02
## PC.ae.C32.2_T2 -5.256756e-02 -3.948619e-03 1.068639e-02 -4.495941e-03
## PC.ae.C34.0_T2 -5.254033e-02 -3.562469e-03 1.103251e-02 -1.613118e-03
## PC.ae.C34.1_T2 -4.645693e-02 3.031314e-02 4.895663e-02 -3.711287e-02
## PC.ae.C34.2_T2 -4.617194e-02 3.563224e-02 5.082014e-02 -3.033178e-02
## PC.ae.C34.3_T2 -4.844283e-02 2.431023e-02 4.018361e-02 -1.851495e-02
## PC.ae.C36.0_T2 -5.258760e-02 3.198468e-03 7.374210e-03 -5.493374e-03
## PC.ae.C36.1_T2 -3.117258e-02 4.693675e-02 -3.237397e-02 2.902262e-03
## PC.ae.C36.2_T2 -4.512749e-02 3.938198e-02 4.617977e-02 -2.463510e-02
## PC.ae.C36.3_T2 -5.032515e-02 1.799711e-02 3.413767e-02 -1.825086e-02
## PC.ae.C36.4_T2 -4.494408e-02 3.281381e-02 5.986622e-02 -4.009632e-02
## PC.ae.C36.5_T2 -4.560357e-02 3.248087e-02 5.238353e-02 -3.456805e-02
## PC.ae.C38.0_T2 -5.193794e-02 8.088385e-03 1.926391e-02 -7.537202e-03
## PC.ae.C38.2_T2 -4.133954e-02 3.041475e-02 -3.077215e-02 1.035068e-02
## PC.ae.C38.3_T2 -3.854888e-02 3.658070e-02 -4.625893e-02 1.518008e-02
## PC.ae.C38.4_T2 -4.751978e-02 3.432325e-02 4.018823e-02 -3.478686e-02
## PC.ae.C38.5_T2 -4.018721e-02 3.833141e-02 6.642050e-02 -5.865205e-02
## PC.ae.C38.6_T2 -4.949739e-02 2.061775e-02 4.156293e-02 -2.144402e-02
## PC.ae.C40.1_T2 -5.075761e-02 1.149852e-02 -2.444890e-03 -3.679518e-03
## PC.ae.C40.2_T2 -5.148151e-02 1.317231e-02 1.771201e-03 -1.264436e-03
## PC.ae.C40.3_T2 -4.283186e-02 2.643150e-02 -4.399597e-02 1.635151e-02
## PC.ae.C40.4_T2 -4.962281e-02 2.384091e-02 -1.290434e-02 -5.914266e-03
## PC.ae.C40.5_T2 -4.731579e-02 3.100539e-02 -3.163526e-02 1.496497e-03
## PC.ae.C40.6_T2 -5.135826e-02 1.550029e-02 2.686007e-02 -1.532806e-02
## PC.ae.C42.1_T2 -5.189516e-02 1.142358e-03 -4.632406e-03 2.442960e-03
## PC.ae.C42.2_T2 -5.205024e-02 3.838136e-04 6.813092e-04 -2.497777e-03
## PC.ae.C42.3_T2 -5.176138e-02 6.231921e-03 -6.203187e-03 5.002887e-04
## PC.ae.C42.4_T2 -5.244812e-02 1.292784e-03 6.611616e-03 -3.296204e-03
## PC.ae.C42.5_T2 -5.161280e-02 1.297242e-02 2.214389e-03 -1.455270e-02
## PC.ae.C44.3_T2 -4.360104e-02 4.895102e-03 2.906923e-02 1.629672e-02
## PC.ae.C44.4_T2 -5.251256e-02 -5.460471e-03 6.536077e-03 -1.266908e-03
## PC.ae.C44.5_T2 -5.106780e-02 6.549883e-04 2.490225e-02 -2.180662e-02
## PC.ae.C44.6_T2 -5.192468e-02 -4.793165e-03 1.721883e-02 -1.264488e-02
## SM..OH..C14.1_T2 -4.880184e-02 1.826323e-02 4.003102e-02 -1.380669e-02
## SM..OH..C16.1_T2 -5.176974e-02 5.650898e-03 2.461918e-02 -1.938129e-03
## SM..OH..C22.1_T2 -4.818457e-02 3.029608e-02 4.304018e-02 -3.241965e-03
## SM..OH..C22.2_T2 -4.752607e-02 3.605125e-02 3.492114e-02 -9.298929e-03
## SM..OH..C24.1_T2 -5.255810e-02 -3.864650e-03 1.121992e-02 1.417137e-04
## SM.C16.0_T2 -1.835175e-02 6.548734e-02 9.266550e-02 -2.850688e-02
## SM.C16.1_T2 -3.935709e-02 3.352410e-02 4.735321e-02 -2.714570e-02
## SM.C18.0_T2 -2.653149e-02 3.169499e-02 6.981412e-02 3.677801e-03
## SM.C18.1_T2 -3.952526e-02 1.579564e-02 4.474842e-02 -9.096202e-03
## SM.C20.2_T2 -5.248856e-02 -8.014355e-03 8.616849e-03 2.762188e-05
## SM.C24.0_T2 -4.357222e-02 4.788717e-02 4.456885e-02 -4.712070e-03
## SM.C24.1_T2 -2.191563e-02 6.491029e-02 8.093587e-02 -2.428401e-02
## MEDDM_T4 -5.232131e-02 -9.587091e-03 7.383240e-03 9.461683e-04
## MEDCOL_T4 -5.233223e-02 -8.672076e-03 8.971278e-03 1.229109e-03
## MEDINF_T4 -5.225489e-02 -1.098214e-02 6.806316e-03 3.441130e-03
## MEDHTA_T4 -5.196640e-02 -4.783872e-03 3.883764e-03 9.995554e-03
## GLU_T4 3.776587e-02 9.708867e-03 -5.493337e-03 1.930741e-02
## INS_T4 -8.057575e-03 -1.788429e-02 2.241292e-02 -8.746490e-03
## HOMA_T4 -4.833630e-02 -1.115173e-02 9.878051e-03 3.709219e-03
## HBA1C_T4 -4.735918e-02 -1.419374e-02 2.491052e-02 -2.095342e-03
## HBA1C.mmol.mol_T4 3.326820e-02 2.034290e-03 4.200954e-02 -4.767790e-03
## PESO_T4 3.288495e-02 -8.905267e-03 -2.403978e-02 -4.005446e-02
## bmi_T4 3.094881e-02 -1.048555e-02 -2.612189e-02 -2.319682e-02
## CC_T4 -5.215970e-02 -1.286902e-02 5.244644e-03 -1.417420e-03
## CINT_T4 4.279097e-02 -2.547964e-03 -8.785329e-03 -1.697358e-02
## CAD_T4 3.820527e-02 1.988881e-03 6.380656e-03 -1.054119e-02
## TAD_T4 3.888406e-02 -2.264666e-03 4.187906e-02 7.651832e-03
## TAS_T4 4.239813e-02 5.360805e-03 4.200986e-02 -1.453473e-02
## TG_T4 2.759201e-02 -1.336125e-02 3.672854e-03 5.090264e-02
## COL_T4 3.621061e-02 -8.279696e-03 7.623956e-02 -7.160270e-04
## LDL_T4 3.831689e-02 8.833033e-03 5.682105e-02 1.894601e-02
## HDL_T4 1.453665e-02 -1.994897e-02 6.643885e-02 -2.669485e-02
## VLDL_T4 9.870018e-03 -4.033020e-02 1.802995e-02 5.564629e-02
## PCR_T4 -2.166929e-02 1.217278e-03 2.833520e-02 -2.946358e-02
## LEP_T4 1.455570e-02 -1.568257e-02 2.964047e-02 -6.557642e-03
## ADIPO_T4 -4.504446e-03 1.127687e-02 -3.303355e-02 -2.535030e-02
## GOT_T4 -5.335540e-03 -2.610513e-02 -1.364143e-02 2.050602e-02
## GPT_T4 3.887932e-03 -2.283927e-02 -3.072336e-02 4.906735e-02
## GGT_T4 3.954245e-03 4.308871e-03 1.292712e-02 1.266444e-03
## URICO_T4 -4.156842e-02 -2.498072e-02 2.054556e-02 1.741022e-02
## CREAT_T4 -5.211554e-02 -1.083001e-02 5.202121e-03 -1.823182e-03
## UREA_T4 1.689411e-02 1.411641e-02 -1.529797e-02 3.072658e-02
## HIERRO_T4 4.260482e-03 -2.449553e-02 1.241037e-02 4.234017e-02
## TRANSF_T4 3.678199e-02 -7.980235e-03 6.058152e-02 1.680610e-03
## FERR_T4 1.079934e-02 1.832551e-02 -3.696757e-02 8.470054e-03
## Ile_T4 9.262907e-03 -8.640029e-02 -4.576903e-02 -4.984219e-02
## Leu_T4 9.422412e-03 -8.796663e-02 -5.678239e-02 -7.056775e-02
## Val_T4 1.001374e-02 -8.727427e-02 -5.667147e-02 -8.636508e-02
## Ala_T4 1.726081e-02 -9.022227e-02 -5.553461e-02 -3.481182e-02
## Pro_T4 1.140462e-02 -6.154606e-02 -6.179894e-02 -7.409421e-02
## Gly_T4 5.556011e-03 -7.761374e-02 -3.371671e-03 -7.567848e-02
## Ser_T4 1.463329e-02 -3.311877e-02 -3.267483e-03 -2.855353e-02
## Trp_T4 -1.381675e-03 -9.454777e-02 -3.107555e-02 -8.216936e-02
## Phe_T4 5.788309e-03 -7.585191e-02 -6.444177e-02 -9.993741e-02
## Met_T4 -1.699207e-02 -6.642533e-02 4.589468e-02 -8.793842e-02
## Orn_T4 -2.300997e-03 -8.507586e-02 -3.841970e-02 -7.731444e-02
## Arg_T4 1.727422e-02 -8.035830e-02 -5.833876e-02 -5.863482e-02
## His_T4 7.593302e-03 -8.450097e-02 -7.253802e-02 -7.107802e-02
## Asn_T4 -3.936490e-03 -1.044768e-01 -1.519229e-02 -8.279319e-02
## Asp_T4 -3.282301e-03 -2.824834e-02 -6.080712e-02 -1.565711e-02
## Glu_T4 2.061895e-02 1.539095e-02 -1.058520e-01 5.156662e-02
## Gln_T4 1.303804e-02 -1.050770e-02 5.064413e-02 4.448180e-02
## Cit_T4 -6.288421e-03 -9.584785e-02 -3.430173e-02 -6.596955e-02
## Tyr_T4 1.554605e-03 -8.454654e-02 -4.993335e-02 -8.158786e-02
## Thr_T4 4.983106e-03 -8.900770e-02 2.722186e-03 -7.678495e-02
## Lys_T4 1.420386e-02 -5.292446e-02 1.299039e-02 -2.968199e-02
## Creatinine_T4 7.388703e-03 -8.833154e-02 -5.368672e-02 -5.931448e-02
## Kynurenine_T4 -1.549081e-02 -5.617529e-03 -3.994171e-02 -5.408187e-02
## Putrescine_T4 -4.081949e-03 -1.353443e-02 2.323255e-02 2.264845e-03
## Sarcosine_T4 -2.423799e-02 -3.485859e-02 -8.979389e-03 1.408779e-02
## Serotonin_T4 -1.100873e-02 7.112118e-03 -9.217869e-03 -3.478700e-02
## Taurine_T4 1.222143e-02 3.682083e-02 5.409716e-02 1.939982e-02
## SDMA_T4 -5.133143e-02 -2.778403e-02 3.129862e-04 -1.014630e-02
## C0_T4 -1.577593e-03 -8.812115e-02 -6.511264e-02 -6.111451e-02
## C2_T4 -2.191465e-02 -8.727889e-02 1.952410e-02 -4.392680e-03
## C3.OH_T4 -5.240269e-02 -9.192554e-03 6.613897e-03 -5.927405e-04
## C6..C4.1.DC._T4 3.086552e-03 3.624466e-02 3.066182e-02 3.903211e-02
## C5.DC..C6.OH._T4 -3.776637e-02 2.286194e-03 -2.741385e-02 -3.617937e-02
## C7.DC_T4 -3.918263e-02 -1.357590e-02 -1.525952e-02 1.418613e-03
## C8_T4 -5.231163e-02 -1.044477e-02 6.015725e-03 -2.244538e-03
## C10_T4 -5.228081e-02 -1.251930e-02 4.201056e-03 -2.919374e-03
## C10.1_T4 -5.238288e-02 -1.119416e-02 5.391740e-03 2.614087e-05
## C10.2_T4 -5.242964e-02 -9.721547e-03 7.304200e-03 2.644183e-04
## C14.1_T4 -5.239423e-02 -1.100754e-02 6.403639e-03 -5.615208e-04
## C14.2_T4 -5.242313e-02 -1.008755e-02 6.660763e-03 4.522273e-04
## C16.1_T4 -4.571691e-02 -1.086825e-02 8.704063e-05 6.301137e-03
## C16.2_T4 -5.244948e-02 -9.609665e-03 6.737918e-03 1.135550e-03
## C16.2.OH_T4 -4.582815e-02 -1.059955e-02 1.470787e-05 6.660216e-03
## C18.1_T4 -5.239694e-02 -1.156639e-02 6.212138e-03 -7.840861e-04
## C18.1.OH_T4 -5.244969e-02 -9.540861e-03 6.859970e-03 9.155320e-04
## C18.2_T4 -5.243200e-02 -1.009875e-02 6.686196e-03 5.992285e-04
## lysoPC.a.C16.0_T4 1.713196e-02 -7.138737e-02 -8.209270e-02 -2.393707e-02
## lysoPC.a.C16.1_T4 -4.027309e-02 -4.251549e-02 -5.491598e-02 -2.199679e-02
## lysoPC.a.C17.0_T4 -4.928457e-02 -2.815814e-02 -2.395334e-02 -1.046205e-02
## lysoPC.a.C18.0_T4 1.413599e-02 -5.238706e-02 -8.900639e-02 -1.301527e-02
## lysoPC.a.C18.1_T4 5.038105e-03 -8.082093e-02 -6.025839e-02 -4.679781e-02
## lysoPC.a.C18.2_T4 -1.491493e-03 -9.588730e-02 -5.134648e-02 -4.717478e-02
## lysoPC.a.C20.3_T4 -4.884794e-02 -3.296966e-02 -2.043077e-02 -3.217678e-03
## lysoPC.a.C20.4_T4 -1.417880e-02 -8.274569e-02 -3.412700e-02 -2.518016e-02
## lysoPC.a.C24.0_T4 -5.245141e-02 -8.250638e-03 3.619021e-03 1.066094e-03
## lysoPC.a.C26.0_T4 -3.856085e-02 -1.341375e-02 -1.743713e-02 -1.873343e-02
## lysoPC.a.C26.1_T4 -5.247117e-02 -9.099357e-03 8.160507e-04 8.595927e-04
## lysoPC.a.C28.0_T4 -3.516106e-02 -1.816111e-02 -4.611272e-02 -2.461032e-02
## lysoPC.a.C28.1_T4 -5.246483e-02 -9.063869e-03 -1.807198e-03 3.881281e-03
## PC.aa.C24.0_T4 -3.164774e-02 -9.324753e-03 -2.704195e-02 -1.317167e-02
## PC.aa.C28.1_T4 -5.022019e-02 -3.179324e-02 5.546469e-03 -1.914702e-02
## PC.aa.C30.0_T4 -5.100076e-02 -2.698390e-02 4.912533e-03 -1.292185e-03
## PC.aa.C32.0_T4 -1.647288e-02 -1.003664e-01 -1.015577e-02 -4.807823e-02
## PC.aa.C32.1_T4 -1.892055e-02 -5.558125e-02 -3.809191e-02 -2.862147e-02
## PC.aa.C32.3_T4 -5.245559e-02 -1.173329e-02 5.160321e-03 3.379655e-04
## PC.aa.C34.1_T4 1.409626e-02 -9.104317e-02 -2.358959e-02 -4.504567e-02
## PC.aa.C34.2_T4 7.209987e-03 -1.071653e-01 -1.273804e-02 -3.102972e-02
## PC.aa.C34.3_T4 -2.922942e-02 -6.244900e-02 -3.840478e-02 -1.984401e-02
## PC.aa.C34.4_T4 -5.232296e-02 -1.387201e-02 4.576163e-03 2.359843e-04
## PC.aa.C36.0_T4 -5.173241e-02 -1.899562e-02 -8.811460e-03 2.920794e-03
## PC.aa.C36.1_T4 -1.032037e-02 -7.115917e-02 -1.124918e-02 -3.905434e-02
## PC.aa.C36.2_T4 7.555204e-03 -9.117929e-02 -9.295991e-03 -4.530973e-02
## PC.aa.C36.3_T4 7.099049e-03 -8.297010e-02 -7.683613e-03 -3.580771e-02
## PC.aa.C36.4_T4 7.730246e-03 -9.962392e-02 1.352704e-02 -2.015163e-02
## PC.aa.C36.5_T4 -2.533029e-02 -6.763111e-02 -2.385244e-02 -3.456147e-02
## PC.aa.C38.0_T4 -4.772214e-02 -4.203239e-02 -5.801135e-03 -2.038307e-02
## PC.aa.C38.1_T4 -5.116917e-02 -1.275558e-02 -1.823866e-02 1.873576e-02
## PC.aa.C38.3_T4 5.259916e-03 -7.584427e-02 -9.527220e-03 -3.220045e-02
## PC.aa.C38.4_T4 9.180663e-03 -9.531148e-02 8.052211e-03 -4.808785e-02
## PC.aa.C38.5_T4 -4.965751e-04 -1.000333e-01 -1.741344e-03 -6.204222e-02
## PC.aa.C38.6_T4 6.768952e-03 -8.764110e-02 -3.264173e-03 -7.004607e-03
## PC.aa.C40.1_T4 -3.389054e-02 -2.801690e-02 -3.432404e-02 -4.573889e-03
## PC.aa.C40.2_T4 -5.092157e-02 2.877257e-03 -2.541736e-02 2.067328e-02
## PC.aa.C40.3_T4 -5.171111e-02 -4.423233e-03 -1.904176e-02 1.375604e-02
## PC.aa.C40.4_T4 -4.928070e-02 -1.818413e-02 -3.194470e-02 2.931356e-03
## PC.aa.C40.5_T4 -4.256444e-02 -5.996266e-02 1.345227e-03 -2.742795e-02
## PC.aa.C40.6_T4 -3.830424e-03 -8.943352e-02 -1.282754e-03 -1.147365e-02
## PC.aa.C42.0_T4 -5.226782e-02 -1.641383e-02 -2.238445e-03 -4.074328e-04
## PC.aa.C42.1_T4 -5.249195e-02 -1.077104e-02 -8.519061e-04 2.153613e-03
## PC.aa.C42.2_T4 -5.244790e-02 -6.414860e-03 -7.032941e-03 6.514160e-03
## PC.aa.C42.4_T4 -5.236424e-02 -4.784123e-03 -9.218458e-03 8.616250e-03
## PC.aa.C42.5_T4 -5.249389e-02 -1.162755e-02 -5.653181e-04 3.276734e-03
## PC.aa.C42.6_T4 -4.000615e-02 -2.481959e-02 -2.258466e-02 -2.354775e-03
## PC.ae.C30.0_T4 -4.191499e-02 -2.207880e-02 1.030657e-02 -1.402873e-02
## PC.ae.C32.1_T4 -4.939342e-02 -4.074802e-02 1.649122e-03 -2.386045e-02
## PC.ae.C32.2_T4 -5.218699e-02 -1.831028e-02 1.679541e-03 -6.964678e-03
## PC.ae.C34.0_T4 -5.235198e-02 -1.424114e-02 5.960183e-03 -3.558667e-03
## PC.ae.C34.1_T4 -4.061515e-02 -6.791533e-02 -7.813853e-04 -5.040955e-02
## PC.ae.C34.2_T4 -3.655876e-02 -7.488340e-02 -6.960182e-03 -5.563544e-02
## PC.ae.C34.3_T4 -3.940780e-02 -6.814094e-02 2.714868e-03 -3.598939e-02
## PC.ae.C36.0_T4 -5.216797e-02 -1.831788e-02 1.998333e-04 -5.647126e-03
## PC.ae.C36.1_T4 -2.673550e-02 1.030129e-02 -9.677020e-02 2.719704e-02
## PC.ae.C36.2_T4 -3.968251e-02 -6.131523e-02 -2.554263e-02 -2.504375e-02
## PC.ae.C36.3_T4 -4.817349e-02 -4.603808e-02 -2.356109e-03 -2.583440e-02
## PC.ae.C36.4_T4 -3.365439e-02 -7.733988e-02 5.319832e-07 -6.532096e-02
## PC.ae.C36.5_T4 -3.441805e-02 -8.167917e-02 4.396732e-03 -5.025253e-02
## PC.ae.C38.0_T4 -5.107980e-02 -2.705217e-02 -4.754182e-03 -4.389361e-03
## PC.ae.C38.2_T4 -3.251521e-02 2.003178e-02 -8.543100e-02 3.823899e-02
## PC.ae.C38.3_T4 -3.276376e-02 2.145729e-02 -8.128558e-02 5.303645e-02
## PC.ae.C38.4_T4 -4.280554e-02 -5.827199e-02 -5.359582e-03 -3.899559e-02
## PC.ae.C38.5_T4 -2.607104e-02 -8.351648e-02 8.783486e-03 -6.756581e-02
## PC.ae.C38.6_T4 -4.580786e-02 -5.588684e-02 5.973495e-03 -3.165104e-02
## PC.ae.C40.1_T4 -5.151444e-02 -1.217382e-02 -2.108544e-02 1.003652e-02
## PC.ae.C40.2_T4 -5.039888e-02 -7.600454e-03 -2.773796e-02 1.385474e-02
## PC.ae.C40.3_T4 -3.745867e-02 1.955701e-02 -7.309303e-02 4.691796e-02
## PC.ae.C40.4_T4 -4.579107e-02 -5.475700e-03 -5.314290e-02 1.583794e-02
## PC.ae.C40.5_T4 -4.060167e-02 -1.832017e-03 -7.349792e-02 1.551030e-02
## PC.ae.C40.6_T4 -5.003971e-02 -3.815300e-02 -1.241504e-03 -1.623764e-02
## PC.ae.C42.1_T4 -5.215109e-02 -5.778763e-03 -1.236943e-02 1.216057e-02
## PC.ae.C42.2_T4 -5.232789e-02 -7.731871e-03 -9.310328e-03 7.574398e-03
## PC.ae.C42.3_T4 -5.168568e-02 -8.194570e-03 -2.183769e-02 8.086212e-03
## PC.ae.C42.4_T4 -5.212115e-02 -1.336107e-02 -8.742491e-03 6.003850e-04
## PC.ae.C42.5_T4 -4.821479e-02 -3.021840e-02 -3.149769e-02 -1.430080e-02
## PC.ae.C44.3_T4 -5.253276e-02 -6.925788e-03 -2.523453e-03 4.897807e-03
## PC.ae.C44.4_T4 -5.243211e-02 -1.157038e-02 2.064830e-03 8.127635e-04
## PC.ae.C44.5_T4 -4.808206e-02 -4.321302e-02 -2.101124e-03 -2.560206e-02
## PC.ae.C44.6_T4 -5.065478e-02 -3.031522e-02 4.643480e-04 -1.293130e-02
## SM..OH..C14.1_T4 -4.464298e-02 -5.221134e-02 8.126572e-03 -3.452157e-02
## SM..OH..C16.1_T4 -5.067272e-02 -2.882120e-02 9.079541e-03 -8.134989e-03
## SM..OH..C22.1_T4 -4.611094e-02 -4.176324e-02 1.554981e-02 -1.572935e-02
## SM..OH..C22.2_T4 -4.448851e-02 -5.348386e-02 -7.229770e-03 -1.426901e-02
## SM..OH..C24.1_T4 -5.228478e-02 -1.415748e-02 6.742601e-03 -1.739562e-04
## SM.C16.0_T4 1.291397e-02 -1.018592e-01 6.458077e-03 -4.162183e-02
## SM.C16.1_T4 -1.581946e-02 -9.631158e-02 -7.437753e-03 -4.231515e-02
## SM.C18.0_T4 -4.589461e-03 -8.799884e-02 8.513275e-03 1.926188e-02
## SM.C18.1_T4 -2.294203e-02 -8.631346e-02 -3.427442e-03 -1.092838e-02
## SM.C20.2_T4 -5.237725e-02 -1.306412e-02 6.092465e-03 6.583696e-04
## SM.C24.0_T4 -3.860105e-02 -5.500487e-02 -2.059113e-03 -1.005620e-02
## SM.C24.1_T4 1.019777e-02 -9.989735e-02 -7.273003e-03 -6.633316e-03
## MEDDM_T5 -5.150080e-02 -3.237145e-03 3.624385e-03 1.010204e-02
## MEDCOL_T5 -5.150080e-02 -3.237145e-03 3.624385e-03 1.010204e-02
## MEDINF_T5 -5.147425e-02 -4.520952e-03 3.540330e-03 1.237918e-02
## MEDHTA_T5 -5.144547e-02 -3.290546e-03 4.415548e-03 9.942508e-03
## GLU_T5 -4.932356e-03 8.827364e-02 2.392928e-02 2.086465e-02
## INS_T5 -3.656599e-02 3.097675e-02 1.651235e-02 3.040778e-02
## HOMA_T5 -5.044671e-02 5.744586e-03 1.377589e-02 1.311854e-02
## HBA1C_T5 -4.740661e-02 -1.726258e-02 2.114776e-02 -1.609879e-03
## HBA1C.mmol.mol_T5 3.435251e-02 -8.243280e-03 2.939061e-02 -3.154598e-03
## PESO_T5 -2.080252e-02 8.848088e-02 -3.398739e-02 -6.389771e-03
## bmi_T5 -2.237296e-02 9.031373e-02 -3.361876e-02 6.714940e-03
## CC_T5 -5.219480e-02 -1.130866e-02 8.353558e-03 1.394497e-03
## CINT_T5 -2.298862e-02 9.986742e-02 -2.057489e-02 2.146791e-02
## CAD_T5 -1.107638e-02 1.027230e-01 -2.940514e-02 2.045903e-03
## TAD_T5 3.879234e-02 5.728967e-03 2.662768e-02 2.104849e-02
## TAS_T5 4.134639e-02 1.224887e-02 1.332890e-02 2.122096e-03
## TG_T5 -1.296414e-02 5.106110e-02 1.744704e-02 6.915014e-02
## COL_T5 1.030419e-02 3.538364e-02 9.360254e-02 2.797949e-02
## LDL_T5 2.068921e-02 4.370577e-02 6.554792e-02 3.320838e-02
## HDL_T5 -9.409149e-03 7.674480e-03 6.183629e-02 1.216976e-02
## VLDL_T5 -3.165450e-02 3.064036e-02 1.568542e-02 7.712265e-02
## PCR_T5 -3.820377e-02 2.402352e-02 3.775250e-02 -4.537154e-02
## LEP_T5 -2.092006e-02 7.537560e-02 2.583980e-02 -1.449497e-02
## ADIPO_T5 -1.194825e-02 2.956043e-02 -1.952951e-02 -9.008070e-03
## GOT_T5 -2.025115e-02 3.161952e-02 -7.807932e-03 8.795260e-03
## GPT_T5 -1.211157e-02 5.657011e-02 -2.766752e-02 2.687791e-02
## GGT_T5 -3.310877e-02 7.348772e-02 -1.661329e-02 4.534138e-02
## URICO_T5 -4.899134e-02 1.976455e-02 2.344549e-04 2.449636e-02
## CREAT_T5 -5.247049e-02 -4.689248e-03 6.840599e-03 -1.884846e-04
## UREA_T5 -1.447445e-02 6.533065e-02 -1.604312e-02 4.974307e-03
## HIERRO_T5 -4.796012e-03 6.332439e-04 1.148873e-02 7.421884e-02
## TRANSF_T5 -1.355665e-02 6.965061e-02 3.776407e-02 2.406428e-02
## FERR_T5 1.195663e-03 2.637314e-02 -4.554595e-02 3.085219e-02
## Ile_T5 3.465359e-02 -8.079058e-03 -2.817134e-02 5.863541e-02
## Leu_T5 3.353699e-02 -1.673166e-02 -1.775763e-02 4.551440e-02
## Val_T5 3.577992e-02 -1.360018e-02 3.709242e-03 3.393547e-02
## Ala_T5 4.356605e-02 1.599638e-02 -1.211484e-02 6.537560e-02
## Pro_T5 3.821640e-02 -8.080291e-03 -1.398297e-02 2.737739e-02
## Gly_T5 2.963037e-02 -2.137027e-02 3.944158e-02 3.703296e-02
## Ser_T5 3.513482e-02 -3.761597e-02 3.179049e-02 1.723059e-02
## Trp_T5 2.121909e-02 -1.242593e-02 4.457891e-02 5.339619e-02
## Phe_T5 3.252321e-02 -2.805376e-03 -1.502318e-02 4.471480e-02
## Met_T5 1.384154e-02 -4.230277e-02 8.062186e-02 2.833562e-02
## Orn_T5 2.846596e-02 -2.453541e-02 2.363622e-02 4.225131e-02
## Arg_T5 3.627374e-02 -3.391671e-04 -2.278124e-03 9.847268e-02
## His_T5 3.298185e-02 -8.154079e-03 -4.140090e-02 7.439198e-02
## Asn_T5 3.107940e-02 -3.627083e-02 4.541242e-02 4.194208e-02
## Asp_T5 9.369929e-03 1.453723e-02 2.249959e-02 4.561277e-02
## Glu_T5 2.226301e-02 4.292080e-02 -7.259913e-02 6.952453e-02
## Gln_T5 2.810448e-02 -5.990639e-02 5.466750e-02 4.683917e-02
## Cit_T5 2.621963e-02 -7.355723e-03 2.464372e-02 6.534109e-02
## Tyr_T5 3.543152e-02 9.604781e-04 8.252083e-03 5.498797e-02
## Thr_T5 3.183640e-02 -1.746851e-02 7.279472e-02 1.029979e-02
## Lys_T5 4.125049e-02 -6.561489e-03 1.465518e-02 6.663065e-02
## Creatinine_T5 2.401439e-02 -2.828510e-02 3.363679e-02 3.403529e-02
## Kynurenine_T5 -6.222454e-03 -8.007623e-03 9.589713e-02 1.346008e-02
## Putrescine_T5 -9.185678e-03 -3.704751e-03 -3.769871e-02 4.288502e-02
## Sarcosine_T5 -2.136796e-02 1.621620e-02 3.700191e-03 3.974124e-02
## Serotonin_T5 -1.326178e-02 1.282109e-03 -1.678207e-02 -3.395655e-02
## Taurine_T5 2.022184e-02 1.322162e-02 1.453510e-02 -3.155788e-02
## SDMA_T5 -5.184739e-02 -1.465096e-02 1.452524e-02 1.157047e-02
## C0_T5 2.960476e-02 4.178836e-03 2.111815e-03 8.299266e-02
## C2_T5 -2.218936e-02 -4.967117e-02 6.677972e-02 4.401575e-02
## C3.OH_T5 -5.238162e-02 -1.044421e-02 7.088899e-03 8.029096e-05
## C6..C4.1.DC._T5 -3.334221e-03 1.183923e-03 -4.458075e-02 3.625662e-02
## C5.DC..C6.OH._T5 -4.574370e-02 -6.148936e-03 -3.807181e-03 -1.703594e-02
## C7.DC_T5 -4.120378e-02 -2.786588e-02 2.621333e-02 -2.092243e-02
## C8_T5 -5.225193e-02 -1.067114e-02 8.435645e-03 8.035746e-05
## C10_T5 -5.216199e-02 -1.137957e-02 8.743399e-03 1.517650e-03
## C10.1_T5 -4.000612e-02 -1.197213e-02 1.832955e-02 3.550731e-02
## C10.2_T5 -5.239715e-02 -1.026692e-02 7.127743e-03 6.733821e-04
## C14.1_T5 -5.238913e-02 -1.048270e-02 7.702819e-03 1.966301e-03
## C14.2_T5 -5.241707e-02 -9.923341e-03 6.784646e-03 1.245400e-03
## C16.1_T5 -5.243229e-02 -9.892061e-03 6.872788e-03 1.296953e-03
## C16.2_T5 -5.244414e-02 -9.750169e-03 6.708102e-03 1.064722e-03
## C16.2.OH_T5 -4.268832e-02 -1.280140e-02 -3.344134e-02 -3.205222e-02
## C18.1_T5 -5.242291e-02 -1.004155e-02 7.210269e-03 2.320689e-03
## C18.1.OH_T5 -5.244673e-02 -9.784750e-03 6.796257e-03 1.004841e-03
## C18.2_T5 -5.243392e-02 -9.888021e-03 6.550968e-03 1.622239e-03
## lysoPC.a.C16.0_T5 2.907325e-02 -1.432611e-02 -4.024542e-03 1.049269e-01
## lysoPC.a.C16.1_T5 -3.770926e-02 -3.027073e-03 -3.943408e-02 5.920804e-02
## lysoPC.a.C17.0_T5 -4.988898e-02 -1.018307e-02 1.042120e-02 3.926384e-02
## lysoPC.a.C18.0_T5 2.688807e-02 6.407240e-03 -4.838211e-03 1.145931e-01
## lysoPC.a.C18.1_T5 2.054466e-02 -2.087372e-02 2.111059e-03 9.161491e-02
## lysoPC.a.C18.2_T5 1.494636e-02 -3.181746e-02 1.523820e-02 1.036081e-01
## lysoPC.a.C20.3_T5 -4.278276e-02 -1.101158e-02 -2.985152e-03 7.534093e-02
## lysoPC.a.C20.4_T5 -1.554890e-03 -2.765956e-02 9.501379e-03 9.692562e-02
## lysoPC.a.C24.0_T5 -5.240408e-02 -8.990629e-03 5.033681e-03 3.108793e-03
## lysoPC.a.C26.0_T5 -5.242397e-02 -6.845549e-03 -4.610364e-04 8.050022e-03
## lysoPC.a.C26.1_T5 -5.240065e-02 -1.021802e-02 5.164947e-03 5.007766e-03
## lysoPC.a.C28.0_T5 -3.058255e-02 -8.995770e-03 4.522804e-03 7.876446e-02
## lysoPC.a.C28.1_T5 -5.243372e-02 -9.282513e-03 4.969562e-03 6.307637e-03
## PC.aa.C24.0_T5 -2.996863e-02 -4.164895e-03 1.888470e-02 1.128320e-02
## PC.aa.C28.1_T5 -5.049343e-02 -2.076042e-02 2.944869e-02 2.385457e-02
## PC.aa.C30.0_T5 -5.022501e-02 -2.013622e-02 1.900439e-02 2.462978e-02
## PC.aa.C32.0_T5 -1.299253e-02 -6.246764e-02 8.907183e-02 9.105592e-02
## PC.aa.C32.1_T5 -1.865142e-02 -2.706506e-02 1.888486e-02 7.939344e-02
## PC.aa.C32.3_T5 -5.244319e-02 -9.996895e-03 7.662508e-03 2.925786e-03
## PC.aa.C34.1_T5 2.626829e-02 -4.407915e-02 7.721770e-02 9.794823e-02
## PC.aa.C34.2_T5 2.013604e-02 -5.430590e-02 8.325655e-02 1.031700e-01
## PC.aa.C34.3_T5 -2.049242e-02 -3.036288e-02 3.911787e-02 1.015323e-01
## PC.aa.C34.4_T5 -5.226023e-02 -1.091114e-02 7.744382e-03 8.979559e-03
## PC.aa.C36.0_T5 -5.154809e-02 -1.118056e-02 3.369201e-03 2.459519e-02
## PC.aa.C36.1_T5 4.658680e-03 -2.188069e-02 7.480618e-02 1.242558e-01
## PC.aa.C36.2_T5 2.214578e-02 -3.266877e-02 8.478424e-02 1.080345e-01
## PC.aa.C36.3_T5 2.272746e-02 -2.994081e-02 7.403130e-02 1.099153e-01
## PC.aa.C36.4_T5 2.079923e-02 -5.039248e-02 7.343672e-02 8.974764e-02
## PC.aa.C36.5_T5 -2.826087e-02 -2.924563e-02 4.671139e-02 7.374215e-02
## PC.aa.C38.0_T5 -4.741980e-02 -2.308284e-02 2.709394e-02 4.359518e-02
## PC.aa.C38.1_T5 -5.146515e-02 -2.945281e-03 5.442573e-03 1.679289e-02
## PC.aa.C38.3_T5 1.901366e-02 -1.173850e-02 4.177319e-02 1.178720e-01
## PC.aa.C38.4_T5 2.479418e-02 -2.775443e-02 8.306046e-02 9.282048e-02
## PC.aa.C38.5_T5 1.667028e-02 -4.590749e-02 9.941096e-02 8.733492e-02
## PC.aa.C38.6_T5 2.250060e-02 -3.984975e-02 6.314098e-02 1.135098e-01
## PC.aa.C40.1_T5 -3.198230e-02 -1.566270e-02 1.408036e-02 5.864319e-02
## PC.aa.C40.2_T5 -5.171586e-02 -8.661961e-04 -1.559623e-02 1.466316e-02
## PC.aa.C40.3_T5 -5.169293e-02 -3.568410e-03 -9.416695e-03 1.329640e-02
## PC.aa.C40.4_T5 -5.019211e-02 -1.275151e-02 8.257900e-03 3.448146e-02
## PC.aa.C40.5_T5 -4.094825e-02 -2.889005e-02 6.263438e-02 6.649408e-02
## PC.aa.C40.6_T5 1.455528e-02 -2.215147e-02 6.117233e-02 1.346530e-01
## PC.aa.C42.0_T5 -5.231470e-02 -1.156519e-02 6.669088e-03 9.862692e-03
## PC.aa.C42.1_T5 -5.246941e-02 -9.591139e-03 4.616755e-03 5.910429e-03
## PC.aa.C42.2_T5 -5.244764e-02 -6.501827e-03 -2.657050e-03 7.038771e-03
## PC.aa.C42.4_T5 -5.238574e-02 -5.151438e-03 -5.477948e-03 8.607143e-03
## PC.aa.C42.5_T5 -5.243442e-02 -9.774281e-03 3.240068e-03 8.726349e-03
## PC.aa.C42.6_T5 -3.883784e-02 4.446195e-03 2.885925e-02 2.931491e-02
## PC.ae.C30.0_T5 -4.338125e-02 1.230531e-03 3.757069e-02 1.544726e-02
## PC.ae.C32.1_T5 -5.000798e-02 -2.463406e-02 3.016962e-02 2.190687e-02
## PC.ae.C32.2_T5 -5.228321e-02 -1.246613e-02 1.090434e-02 6.976597e-03
## PC.ae.C34.0_T5 -5.230840e-02 -1.059795e-02 1.208706e-02 5.232805e-03
## PC.ae.C34.1_T5 -4.048060e-02 -3.767488e-02 7.322595e-02 5.577031e-02
## PC.ae.C34.2_T5 -3.249940e-02 -4.658514e-02 7.552751e-02 6.816774e-02
## PC.ae.C34.3_T5 -3.650278e-02 -4.556629e-02 5.977278e-02 5.952175e-02
## PC.ae.C36.0_T5 -5.214814e-02 -1.253209e-02 1.143110e-02 1.205451e-02
## PC.ae.C36.1_T5 -3.399604e-02 1.780170e-02 -4.805272e-02 6.258786e-02
## PC.ae.C36.2_T5 -3.698098e-02 -2.696795e-02 5.992963e-02 7.752413e-02
## PC.ae.C36.3_T5 -4.709058e-02 -2.744909e-02 4.481171e-02 3.842484e-02
## PC.ae.C36.4_T5 -3.082485e-02 -5.476116e-02 7.887616e-02 5.879241e-02
## PC.ae.C36.5_T5 -2.920571e-02 -5.754691e-02 7.636102e-02 6.537629e-02
## PC.ae.C38.0_T5 -5.165695e-02 -1.421318e-02 1.269032e-02 2.363743e-02
## PC.ae.C38.2_T5 -3.716498e-02 1.788185e-02 -5.784289e-02 4.351079e-02
## PC.ae.C38.3_T5 -4.081035e-02 2.084427e-02 -4.695902e-02 6.010280e-02
## PC.ae.C38.4_T5 -4.211157e-02 -2.866996e-02 6.975017e-02 5.656605e-02
## PC.ae.C38.5_T5 -1.797039e-02 -5.504358e-02 9.519102e-02 6.293168e-02
## PC.ae.C38.6_T5 -4.478431e-02 -3.529525e-02 5.314466e-02 4.865804e-02
## PC.ae.C40.1_T5 -5.186014e-02 -7.165665e-03 -3.167751e-03 2.450672e-02
## PC.ae.C40.2_T5 -5.085067e-02 -1.608866e-03 -1.202225e-02 3.121778e-02
## PC.ae.C40.3_T5 -4.110564e-02 2.082306e-02 -5.621954e-02 5.430364e-02
## PC.ae.C40.4_T5 -4.847784e-02 2.352035e-03 -1.905042e-02 4.171745e-02
## PC.ae.C40.5_T5 -4.479973e-02 5.846900e-03 -3.249299e-02 5.523492e-02
## PC.ae.C40.6_T5 -5.007202e-02 -2.001413e-02 3.049148e-02 3.288928e-02
## PC.ae.C42.1_T5 -5.233277e-02 -5.129929e-03 -5.171104e-03 1.303470e-02
## PC.ae.C42.2_T5 -5.240686e-02 -5.697950e-03 -1.342449e-03 1.010146e-02
## PC.ae.C42.3_T5 -5.199001e-02 -5.210296e-03 -7.307275e-03 1.701921e-02
## PC.ae.C42.4_T5 -5.214477e-02 -9.002769e-03 2.398404e-03 1.525033e-02
## PC.ae.C42.5_T5 -4.919234e-02 -1.100229e-02 -5.061407e-03 4.178787e-02
## PC.ae.C44.3_T5 -5.249463e-02 -6.823690e-03 -1.539056e-03 6.112403e-03
## PC.ae.C44.4_T5 -5.240055e-02 -9.800095e-03 6.272282e-03 6.023474e-03
## PC.ae.C44.5_T5 -4.952147e-02 -2.504813e-02 2.919331e-02 2.260792e-02
## PC.ae.C44.6_T5 -5.081071e-02 -2.120197e-02 1.897629e-02 1.626352e-02
## SM..OH..C14.1_T5 -4.546559e-02 -2.704088e-02 6.026883e-02 3.922726e-02
## SM..OH..C16.1_T5 -5.123293e-02 -1.555209e-02 2.719542e-02 1.767007e-02
## SM..OH..C22.1_T5 -4.081127e-02 -3.174242e-02 5.776840e-02 4.910790e-02
## SM..OH..C22.2_T5 -4.280667e-02 -2.744135e-02 4.966870e-02 6.182782e-02
## SM..OH..C24.1_T5 -5.225125e-02 -1.193210e-02 1.215401e-02 4.825664e-03
## SM.C16.0_T5 2.511732e-02 -4.307651e-02 9.079469e-02 9.336900e-02
## SM.C16.1_T5 -1.059342e-02 -5.039223e-02 9.530042e-02 7.761307e-02
## SM.C18.0_T5 1.577563e-03 -3.445486e-02 7.254780e-02 1.129948e-01
## SM.C18.1_T5 -2.851238e-02 -3.932298e-02 6.635420e-02 7.695362e-02
## SM.C20.2_T5 -5.234350e-02 -1.104973e-02 8.486420e-03 4.303566e-03
## SM.C24.0_T5 -2.543839e-02 -4.487573e-02 4.899507e-02 9.971798e-02
## SM.C24.1_T5 1.987643e-02 -4.300291e-02 6.967238e-02 1.136367e-01
## PC5 PC6 PC7 PC8
## GLU_T0 -1.720638e-02 5.225217e-02 -8.167498e-02 -9.482512e-02
## INS_T0 -4.680565e-03 1.730841e-02 -9.167174e-02 -3.646095e-02
## HOMA_T0 -3.741193e-03 1.957496e-02 -8.456639e-02 -3.776664e-02
## HBA1C_T0 -3.651642e-03 -7.550311e-02 2.605982e-02 -4.682885e-02
## HBA1C.mmol.mol_T0 -7.868349e-03 -9.884411e-02 5.186465e-02 -8.635331e-02
## PESO_T0 -1.571945e-02 -1.853918e-02 -1.015980e-01 -4.935067e-02
## bmi_T0 -1.499417e-02 -2.546247e-03 -7.231073e-02 -8.336802e-02
## CC_T0 -8.783815e-04 -1.672638e-02 -6.702046e-03 -3.477634e-03
## CINT_T0 -9.147539e-03 6.461575e-03 -5.710439e-02 -2.950765e-02
## CAD_T0 -2.201109e-02 4.748038e-03 -2.472878e-02 -8.230949e-02
## TAD_T0 1.245867e-03 -5.554776e-02 3.420465e-02 -1.381334e-01
## TAS_T0 -2.246549e-03 -6.898702e-02 3.331780e-02 -7.178541e-02
## TG_T0 1.198507e-03 1.147710e-01 -2.812192e-02 -1.178921e-01
## COL_T0 -5.145790e-02 6.776599e-02 4.855158e-02 -1.474685e-01
## LDL_T0 -5.645871e-02 5.741456e-02 3.208877e-03 -1.039765e-01
## HDL_T0 9.606825e-03 -2.049912e-02 1.517202e-01 -6.373278e-02
## VLDL_T0 1.300810e-03 1.127417e-01 -2.928555e-02 -1.193238e-01
## PCR_T0 -6.154786e-02 2.831460e-02 -2.763230e-02 -4.876511e-02
## LEP_T0 -2.436914e-02 6.605562e-02 -3.959974e-02 -5.872691e-02
## ADIPO_T0 5.368261e-02 -3.865827e-02 1.314290e-01 -6.910006e-02
## GOT_T0 6.108101e-02 2.095381e-02 -2.327114e-02 2.338151e-02
## GPT_T0 2.777123e-02 -1.406648e-02 -9.987168e-02 -2.821359e-02
## GGT_T0 4.267764e-03 5.452914e-02 -6.165759e-02 1.632076e-02
## URICO_T0 -5.514437e-03 -2.317072e-02 -3.966028e-02 -2.211302e-02
## CREAT_T0 -2.221790e-03 -1.696298e-02 -6.561388e-03 -1.009235e-02
## UREA_T0 2.230292e-02 -6.647338e-03 5.907549e-02 -3.659304e-02
## HIERRO_T0 -1.598124e-02 -7.663829e-03 9.753732e-02 -4.882519e-02
## TRANSF_T0 -2.004095e-02 -4.090444e-02 6.306716e-02 -8.195304e-02
## FERR_T0 1.554729e-02 -8.481643e-02 -5.392052e-02 5.102036e-02
## Ile_T0 -5.137047e-02 -1.814508e-02 -9.762338e-02 6.681650e-02
## Leu_T0 -4.979559e-02 -3.952419e-02 -6.160850e-02 9.519243e-02
## Val_T0 -8.624054e-02 -6.936978e-02 -5.354972e-02 7.621330e-02
## Ala_T0 -5.731886e-02 1.032876e-02 -3.375025e-02 -3.066922e-02
## Pro_T0 -5.170318e-02 3.301973e-04 -3.183349e-02 4.499325e-02
## Gly_T0 2.584130e-02 9.960660e-03 8.524526e-02 -1.637441e-02
## Ser_T0 9.667183e-03 7.528748e-04 2.183134e-02 3.237344e-02
## Trp_T0 -7.514744e-02 -4.320357e-02 -1.008027e-02 7.696338e-02
## Phe_T0 -3.174623e-03 -1.305164e-02 -3.630534e-02 5.554906e-02
## Met_T0 -4.561577e-02 -8.413285e-02 -1.434409e-02 6.786305e-02
## Orn_T0 2.626557e-02 -3.866191e-02 5.930407e-02 1.107789e-01
## Arg_T0 3.758529e-03 2.559945e-02 -9.669983e-03 3.575544e-02
## His_T0 -5.772913e-02 -4.527846e-02 5.579843e-02 9.148808e-03
## Asn_T0 -7.118079e-02 -7.034770e-02 5.249856e-02 7.005387e-02
## Asp_T0 5.081524e-02 6.263675e-02 -1.416829e-02 2.775880e-03
## Glu_T0 2.911597e-02 5.553226e-02 -2.818070e-02 1.876658e-02
## Gln_T0 -8.858740e-02 -9.707748e-02 2.529117e-02 4.358871e-02
## Cit_T0 -3.348022e-02 -2.887103e-02 6.845149e-02 3.061526e-02
## Tyr_T0 -3.299038e-02 -5.502142e-02 -2.302697e-02 5.891471e-02
## Thr_T0 -3.758933e-02 -3.088679e-02 7.741645e-06 3.502390e-02
## Lys_T0 -8.360483e-02 -2.639707e-02 -2.841377e-02 9.333770e-02
## Creatinine_T0 -7.268980e-02 -1.946597e-02 -5.505576e-02 -1.971956e-03
## Kynurenine_T0 -2.184854e-02 -2.927665e-02 -2.226942e-03 1.634914e-02
## Putrescine_T0 -1.422032e-03 2.653869e-02 -2.151411e-02 -8.102914e-02
## Sarcosine_T0 -4.702161e-02 -3.998080e-02 -8.360544e-02 4.504707e-03
## Serotonin_T0 -3.660384e-02 -4.174247e-02 -3.714212e-02 2.028322e-02
## Taurine_T0 2.303257e-02 8.874477e-03 5.537447e-02 5.992887e-02
## SDMA_T0 -1.083996e-02 -1.442000e-02 -5.837398e-03 5.334632e-03
## C0_T0 -5.546852e-02 -9.703710e-03 7.288252e-03 6.949636e-02
## C2_T0 -5.357889e-02 -1.853974e-02 -7.294737e-04 3.031611e-02
## C3.OH_T0 -8.049950e-04 -1.685275e-02 -5.720577e-03 -4.501664e-03
## C6..C4.1.DC._T0 6.345401e-02 1.514277e-02 2.980171e-02 1.486396e-02
## C5.DC..C6.OH._T0 7.444036e-03 3.325842e-02 -1.126359e-02 -5.711161e-02
## C7.DC_T0 2.030726e-02 9.218933e-03 -3.946623e-02 -6.761951e-02
## C8_T0 5.195643e-04 -1.544026e-02 -6.039082e-03 -5.888426e-03
## C10_T0 -5.194313e-03 -1.390781e-02 -8.961734e-03 -8.080121e-03
## C10.1_T0 -1.149999e-03 -1.654954e-02 -5.999145e-03 -2.400591e-03
## C10.2_T0 -1.097363e-03 -1.741047e-02 -6.384232e-03 -4.243890e-03
## C14.1_T0 -1.253263e-03 -1.556003e-02 -7.347215e-03 -4.047762e-03
## C14.2_T0 -3.964059e-04 -1.654552e-02 -6.779788e-03 -4.183592e-03
## C16.1_T0 -4.211973e-04 -1.642898e-02 -6.473875e-03 -3.383211e-03
## C16.2_T0 1.722988e-04 -1.658912e-02 -5.823732e-03 -3.149858e-03
## C16.2.OH_T0 3.835253e-04 -1.642682e-02 -5.763418e-03 -3.266227e-03
## C18.1_T0 -5.738362e-04 -1.499314e-02 -5.094615e-03 -3.146759e-03
## C18.1.OH_T0 3.341911e-04 -1.667711e-02 -5.460129e-03 -3.208975e-03
## C18.2_T0 -8.515310e-05 -1.642368e-02 -5.634036e-03 -2.927529e-03
## lysoPC.a.C16.0_T0 -1.995276e-02 5.948158e-02 3.836247e-02 -1.932225e-02
## lysoPC.a.C16.1_T0 -9.343917e-03 2.293789e-02 2.386768e-02 -3.062042e-02
## lysoPC.a.C17.0_T0 3.778171e-04 2.923538e-03 2.190826e-02 -1.362318e-02
## lysoPC.a.C18.0_T0 -4.834820e-03 3.863049e-02 7.027255e-02 -4.261001e-03
## lysoPC.a.C18.1_T0 -4.225782e-02 2.608724e-02 6.014253e-02 -2.527009e-02
## lysoPC.a.C18.2_T0 -5.465281e-02 -3.844544e-02 6.696464e-02 2.407618e-02
## lysoPC.a.C20.3_T0 -3.637022e-02 -1.191781e-03 3.786481e-02 -1.880932e-02
## lysoPC.a.C20.4_T0 -6.922633e-02 -9.356772e-03 3.990059e-02 1.728300e-02
## lysoPC.a.C24.0_T0 -1.561510e-03 -1.288768e-02 -2.857343e-03 -7.335436e-03
## lysoPC.a.C26.0_T0 -1.616745e-02 1.731921e-02 2.893751e-03 -2.142149e-02
## lysoPC.a.C26.1_T0 -1.729590e-03 -1.368794e-02 -6.056346e-03 -5.898450e-03
## lysoPC.a.C28.0_T0 4.752687e-03 3.482702e-03 3.577506e-02 -9.533845e-03
## lysoPC.a.C28.1_T0 -1.893440e-03 -7.688304e-03 -3.171737e-03 -9.315131e-03
## PC.aa.C24.0_T0 -7.983825e-03 -5.865434e-04 9.092212e-03 4.676275e-03
## PC.aa.C28.1_T0 -3.280171e-02 -1.913532e-02 7.975742e-03 -5.340965e-03
## PC.aa.C30.0_T0 -2.399085e-02 -6.928877e-03 4.078529e-03 -6.915216e-03
## PC.aa.C32.0_T0 -8.762208e-02 6.070100e-03 -2.024989e-02 -6.062551e-03
## PC.aa.C32.1_T0 -7.973980e-02 4.021222e-02 2.102517e-02 -5.529703e-02
## PC.aa.C32.3_T0 -1.634294e-03 -1.442280e-02 -4.024442e-03 -3.545690e-03
## PC.aa.C34.1_T0 -1.358691e-01 6.207255e-02 1.554621e-02 -4.307656e-02
## PC.aa.C34.2_T0 -1.123287e-01 1.886532e-02 1.450294e-02 -4.542198e-03
## PC.aa.C34.3_T0 -7.558684e-02 2.855907e-02 4.723807e-02 -3.041284e-02
## PC.aa.C34.4_T0 -1.114983e-02 -1.466927e-02 4.880546e-03 -9.268556e-04
## PC.aa.C36.0_T0 -4.866453e-03 1.096711e-02 9.491798e-03 -4.336857e-03
## PC.aa.C36.1_T0 -8.995863e-02 4.629354e-03 6.238861e-02 1.911958e-02
## PC.aa.C36.2_T0 -1.065939e-01 -1.792491e-02 8.123840e-02 4.749818e-02
## PC.aa.C36.3_T0 -1.181771e-01 3.399225e-02 4.548404e-02 -1.760972e-02
## PC.aa.C36.4_T0 -1.507633e-01 2.487290e-02 2.653414e-02 3.092012e-02
## PC.aa.C36.5_T0 -9.318970e-02 1.338077e-02 1.927210e-02 -9.116457e-03
## PC.aa.C38.0_T0 -2.628371e-02 1.543167e-02 2.688698e-02 3.004131e-03
## PC.aa.C38.1_T0 4.536433e-02 2.736050e-02 1.142073e-02 4.422727e-02
## PC.aa.C38.3_T0 -1.040235e-01 2.104650e-02 5.442356e-02 1.178817e-02
## PC.aa.C38.4_T0 -1.375978e-01 6.906655e-03 7.441293e-02 5.955489e-02
## PC.aa.C38.5_T0 -1.360513e-01 1.946649e-02 7.619882e-02 1.220394e-02
## PC.aa.C38.6_T0 -1.293613e-01 5.835488e-02 -2.094383e-03 1.803024e-02
## PC.aa.C40.1_T0 -1.007534e-02 1.674150e-02 1.933822e-02 1.014350e-02
## PC.aa.C40.2_T0 2.054555e-02 2.057545e-02 5.585775e-03 -1.713532e-02
## PC.aa.C40.3_T0 1.201239e-02 1.621059e-02 5.295341e-03 -1.596623e-02
## PC.aa.C40.4_T0 -7.560109e-03 1.638590e-02 1.959575e-02 5.641087e-04
## PC.aa.C40.5_T0 -6.222018e-02 5.328775e-03 3.972368e-02 1.891533e-02
## PC.aa.C40.6_T0 -1.213666e-01 4.723530e-02 1.831895e-02 5.592893e-02
## PC.aa.C42.0_T0 -3.384753e-04 -5.771281e-03 -2.023808e-03 -3.683554e-03
## PC.aa.C42.1_T0 1.536492e-03 -5.732066e-03 -1.758631e-03 -4.819984e-03
## PC.aa.C42.2_T0 6.728100e-03 1.601493e-03 8.878431e-04 -9.612972e-03
## PC.aa.C42.4_T0 1.079405e-02 4.747745e-04 2.569766e-03 -1.080221e-02
## PC.aa.C42.5_T0 2.582920e-03 -6.418000e-03 -5.546819e-04 -6.565432e-03
## PC.aa.C42.6_T0 -9.373045e-03 1.035186e-03 3.348758e-02 8.827461e-03
## PC.ae.C30.0_T0 -1.338956e-03 -1.545288e-02 -2.544031e-03 -6.353871e-03
## PC.ae.C32.1_T0 -2.601108e-02 -2.400430e-02 6.346597e-03 -4.861273e-03
## PC.ae.C32.2_T0 -4.140936e-03 -1.560429e-02 3.069318e-03 -3.652162e-03
## PC.ae.C34.0_T0 -4.019683e-03 -1.529466e-02 -1.046053e-03 -7.209058e-04
## PC.ae.C34.1_T0 -5.235666e-02 -1.821602e-03 2.540444e-02 -8.241284e-03
## PC.ae.C34.2_T0 -5.706711e-02 -3.910851e-02 6.903988e-02 1.429663e-02
## PC.ae.C34.3_T0 -4.383190e-02 -3.545553e-02 4.977467e-02 1.912311e-02
## PC.ae.C36.0_T0 -5.235953e-03 -3.264953e-03 3.508926e-03 -8.524646e-03
## PC.ae.C36.1_T0 1.866281e-02 5.270931e-02 1.827000e-02 -2.680179e-02
## PC.ae.C36.2_T0 -2.318909e-02 1.469721e-02 5.072248e-02 -1.326027e-02
## PC.ae.C36.3_T0 -4.434208e-02 -2.650860e-02 4.082930e-02 1.552741e-02
## PC.ae.C36.4_T0 -8.882630e-02 -6.402228e-02 4.444892e-02 5.145780e-02
## PC.ae.C36.5_T0 -8.686783e-02 -5.279710e-02 3.934474e-02 3.862369e-02
## PC.ae.C38.0_T0 -2.114916e-02 -7.383581e-04 1.324741e-02 -1.162616e-02
## PC.ae.C38.2_T0 4.363949e-02 5.447120e-02 3.109223e-02 -4.030964e-02
## PC.ae.C38.3_T0 2.251487e-02 4.497601e-02 8.119311e-03 -4.358758e-03
## PC.ae.C38.4_T0 -5.871994e-02 -1.710438e-02 3.978414e-02 3.367602e-02
## PC.ae.C38.5_T0 -1.054947e-01 -3.663010e-02 4.535264e-02 6.952506e-02
## PC.ae.C38.6_T0 -6.775473e-02 -2.766233e-02 2.528899e-02 3.025771e-02
## PC.ae.C40.1_T0 1.541510e-03 1.496883e-02 9.974178e-03 -1.410046e-02
## PC.ae.C40.2_T0 2.551408e-02 2.865062e-02 1.227763e-02 -2.580354e-02
## PC.ae.C40.3_T0 3.878820e-02 4.275935e-02 1.210894e-02 -1.321489e-02
## PC.ae.C40.4_T0 1.397030e-02 2.240093e-02 1.841033e-02 -5.708208e-03
## PC.ae.C40.5_T0 1.469480e-02 2.967998e-02 1.396232e-02 -6.595387e-03
## PC.ae.C40.6_T0 -2.906283e-02 -1.362632e-02 8.384364e-03 8.826663e-03
## PC.ae.C42.1_T0 9.406807e-03 1.054053e-02 4.049812e-03 -1.241204e-02
## PC.ae.C42.2_T0 5.632220e-03 3.395982e-03 2.729262e-03 -1.066297e-02
## PC.ae.C42.3_T0 9.635461e-03 6.570715e-03 6.286944e-03 -1.427222e-02
## PC.ae.C42.4_T0 1.946517e-03 -6.975062e-03 3.670406e-03 -4.764727e-03
## PC.ae.C42.5_T0 7.755425e-04 2.655460e-03 8.816230e-03 -5.572373e-03
## PC.ae.C44.3_T0 7.631846e-03 -5.533673e-03 -6.850433e-04 -8.754091e-03
## PC.ae.C44.4_T0 1.008239e-03 -1.222418e-02 -5.388078e-04 -7.079159e-03
## PC.ae.C44.5_T0 -2.071341e-02 -3.508820e-02 4.879852e-04 4.048929e-03
## PC.ae.C44.6_T0 -9.501347e-03 -3.081684e-02 6.255986e-03 1.050685e-02
## SM..OH..C14.1_T0 -3.141344e-02 -2.799530e-02 1.121089e-02 1.003209e-03
## SM..OH..C16.1_T0 -1.588592e-02 -1.852399e-02 -7.180153e-03 -2.388051e-03
## SM..OH..C22.1_T0 -9.104943e-02 -3.802572e-02 6.990730e-03 1.814329e-02
## SM..OH..C22.2_T0 -5.178924e-02 -2.480375e-03 2.360438e-02 -6.091544e-03
## SM..OH..C24.1_T0 -8.649874e-03 -1.966559e-02 -6.434049e-03 1.124302e-03
## SM.C16.0_T0 -1.488562e-01 -2.262330e-02 -2.134145e-02 4.166406e-02
## SM.C16.1_T0 -1.130297e-01 -1.969845e-02 1.669600e-02 1.420524e-02
## SM.C18.0_T0 -9.126795e-02 2.476338e-02 -9.998411e-02 7.515556e-03
## SM.C18.1_T0 -7.861392e-02 5.088848e-03 -4.145136e-02 -6.687798e-03
## SM.C20.2_T0 -2.986033e-03 -1.536661e-02 -6.170579e-03 -2.569133e-03
## SM.C24.0_T0 -1.067910e-01 -2.352615e-02 -6.989770e-03 1.212503e-02
## SM.C24.1_T0 -1.317757e-01 3.616167e-02 -4.653525e-02 1.629150e-02
## MEDDM_T2 5.335230e-04 -1.671410e-02 -5.427374e-03 -2.991869e-03
## MEDCOL_T2 5.335230e-04 -1.671410e-02 -5.427374e-03 -2.991869e-03
## MEDINF_T2 -1.621857e-03 -1.473630e-02 -3.032059e-03 -2.519910e-03
## MEDHTA_T2 -2.083133e-04 -2.368360e-02 -1.279995e-02 -1.143359e-02
## GLU_T2 -1.118887e-02 -5.800370e-02 8.254125e-03 -1.092430e-01
## INS_T2 3.090819e-02 -1.930247e-02 -1.230006e-01 -6.664509e-02
## HOMA_T2 1.440253e-02 -2.047260e-02 -8.632747e-02 -5.830863e-02
## HBA1C_T2 -2.599691e-04 -6.317939e-02 3.261653e-02 -3.200315e-02
## HBA1C.mmol.mol_T2 2.548893e-03 -9.128519e-02 9.628494e-02 -6.058926e-02
## PESO_T2 -8.422618e-03 -1.074308e-01 -8.275442e-02 -3.714993e-02
## bmi_T2 -7.553918e-03 -9.080199e-02 -4.640095e-02 -7.189316e-02
## CC_T2 5.353340e-04 -2.547399e-02 -5.263104e-03 -4.043000e-03
## CINT_T2 -3.628044e-03 -9.286452e-02 -4.509006e-02 -2.668227e-02
## CAD_T2 -1.030943e-02 -7.455611e-02 -5.792459e-03 -6.552317e-02
## TAD_T2 1.854242e-02 -4.129855e-02 4.584529e-02 -2.928613e-02
## TAS_T2 -8.975238e-03 -8.755485e-02 4.203579e-02 -1.106377e-02
## TG_T2 -8.086568e-03 2.133527e-02 -6.690457e-02 -1.054053e-01
## COL_T2 -3.390887e-02 4.053377e-02 5.647826e-02 -9.609843e-02
## LDL_T2 -3.529295e-02 4.725990e-02 1.961007e-02 -5.152556e-02
## HDL_T2 -1.236031e-02 -4.874211e-03 1.700483e-01 -3.913569e-02
## VLDL_T2 1.734216e-02 -1.787368e-03 -7.586753e-02 -1.041669e-01
## PCR_T2 -5.048295e-02 -5.045871e-02 -2.795160e-02 -7.567664e-02
## LEP_T2 -2.613449e-02 -2.895721e-03 -2.138457e-02 -1.238293e-01
## ADIPO_T2 5.953662e-02 -6.960679e-02 1.319751e-01 -1.363074e-01
## GOT_T2 7.922514e-02 -6.309165e-02 -3.240167e-02 1.361872e-02
## GPT_T2 2.797536e-02 -1.220010e-01 -9.896424e-02 6.792265e-03
## GGT_T2 4.093309e-03 -1.092805e-02 -3.107587e-02 -2.375686e-02
## URICO_T2 6.449549e-03 -9.003131e-02 -7.113357e-02 -6.111930e-02
## CREAT_T2 -1.101451e-03 -2.428540e-02 -8.121712e-03 -1.727923e-02
## UREA_T2 9.246213e-03 -6.329688e-02 1.065763e-02 -9.997231e-03
## HIERRO_T2 2.519406e-02 -6.479921e-02 4.174764e-02 -2.156146e-02
## TRANSF_T2 -5.450842e-03 2.204272e-02 3.987572e-02 -5.594969e-02
## FERR_T2 2.388398e-02 -1.071755e-01 -2.777856e-02 1.422247e-02
## Ile_T2 1.721587e-02 2.206445e-02 -8.740408e-02 1.344094e-02
## Leu_T2 4.333834e-02 1.040659e-02 -8.080355e-02 1.721225e-03
## Val_T2 3.157222e-02 3.083556e-02 -8.045533e-02 1.987207e-02
## Ala_T2 2.511295e-02 2.607178e-02 -3.506455e-02 3.353766e-02
## Pro_T2 2.682571e-02 3.102300e-02 -1.958630e-02 7.097354e-02
## Gly_T2 6.015683e-02 8.152288e-03 7.403439e-02 -1.341439e-02
## Ser_T2 5.469659e-02 -3.715034e-03 6.888119e-02 1.962146e-02
## Trp_T2 1.051456e-02 2.220434e-05 -4.249277e-02 6.963794e-02
## Phe_T2 5.919895e-02 -1.875741e-03 -5.919607e-02 1.386829e-02
## Met_T2 -4.358204e-02 -1.350427e-02 3.030178e-02 -2.177592e-02
## Orn_T2 8.910752e-02 3.440769e-03 3.481043e-02 9.715690e-02
## Arg_T2 6.449982e-02 1.334019e-02 1.130873e-02 2.978265e-02
## His_T2 5.598669e-02 -1.558040e-02 6.451985e-03 -5.906079e-03
## Asn_T2 2.967764e-02 -2.541473e-02 1.983555e-02 6.247737e-02
## Asp_T2 9.303459e-02 3.777466e-02 8.463650e-03 1.013563e-01
## Glu_T2 8.972179e-02 5.666394e-02 -2.963553e-02 6.097157e-02
## Gln_T2 1.979045e-03 -3.800938e-02 2.249517e-02 4.005224e-02
## Cit_T2 5.104910e-02 1.006388e-02 2.982796e-02 7.170646e-02
## Tyr_T2 3.225136e-02 1.711157e-02 -4.908838e-02 7.053955e-02
## Thr_T2 1.405572e-02 -3.251896e-02 3.622022e-02 1.057131e-01
## Lys_T2 3.625433e-02 2.472168e-02 -4.211960e-02 8.376134e-02
## Creatinine_T2 1.057030e-02 -4.221868e-02 -8.522527e-02 -2.521644e-02
## Kynurenine_T2 4.286078e-03 -1.084459e-02 -2.183669e-02 1.270585e-02
## Putrescine_T2 -3.517004e-02 4.758360e-02 -1.088779e-01 -7.627085e-03
## Sarcosine_T2 -1.389908e-02 -3.597845e-02 -8.449580e-02 1.159279e-02
## Serotonin_T2 2.677595e-03 -7.077001e-03 -5.041005e-02 -4.238170e-02
## Taurine_T2 -1.135532e-02 4.302486e-02 7.650946e-02 8.742790e-03
## SDMA_T2 2.331070e-03 -1.687652e-02 -1.117736e-02 -1.308855e-02
## C0_T2 5.136815e-02 1.912499e-02 -4.566347e-03 6.330069e-02
## C2_T2 -2.619780e-02 -1.845573e-02 6.319407e-03 -3.738991e-03
## C3.OH_T2 -3.210998e-04 -1.654680e-02 -5.493435e-03 -4.559499e-03
## C6..C4.1.DC._T2 -4.799601e-02 -1.765527e-02 -4.809238e-02 6.924043e-02
## C5.DC..C6.OH._T2 7.977267e-03 -2.763121e-02 -1.523796e-02 -2.478041e-02
## C7.DC_T2 -6.199207e-03 -6.434166e-04 3.408793e-02 -4.390904e-02
## C8_T2 -2.038211e-04 -1.568240e-02 -3.131575e-03 -5.629342e-03
## C10_T2 2.576608e-04 -1.564540e-02 -2.324640e-03 -4.254671e-03
## C10.1_T2 8.993374e-04 -1.705864e-02 -3.760236e-03 -2.635805e-03
## C10.2_T2 -1.168486e-03 -1.583713e-02 -4.687215e-03 -4.230737e-03
## C14.1_T2 8.301354e-04 -1.734898e-02 -5.369053e-03 -4.701638e-03
## C14.2_T2 3.900950e-04 -1.744887e-02 -4.983423e-03 -5.154641e-03
## C16.1_T2 3.981869e-04 -1.663127e-02 -5.459102e-03 -4.131066e-03
## C16.2_T2 1.703462e-04 -1.667970e-02 -5.303536e-03 -3.501014e-03
## C16.2.OH_T2 4.198663e-04 -1.670490e-02 -5.096444e-03 -3.297112e-03
## C18.1_T2 9.965502e-04 -1.652432e-02 -5.393868e-03 -3.573192e-03
## C18.1.OH_T2 3.563761e-04 -1.662586e-02 -5.484417e-03 -3.195867e-03
## C18.2_T2 5.830794e-04 -1.698207e-02 -6.357399e-03 -2.959610e-03
## lysoPC.a.C14.0_T2 4.129155e-02 1.482926e-02 -2.949976e-02 2.092916e-02
## lysoPC.a.C16.0_T2 4.867326e-02 6.091244e-02 2.343420e-02 3.995517e-02
## lysoPC.a.C16.1_T2 2.112456e-02 7.879195e-03 -3.084212e-03 3.967863e-03
## lysoPC.a.C17.0_T2 1.870546e-02 1.829343e-03 9.362323e-03 2.559791e-03
## lysoPC.a.C18.0_T2 4.008249e-02 5.508928e-02 4.925094e-02 5.926997e-02
## lysoPC.a.C18.1_T2 3.494736e-02 3.657744e-02 3.136254e-02 2.450641e-02
## lysoPC.a.C18.2_T2 2.967963e-02 2.411989e-02 4.622274e-02 5.362413e-02
## lysoPC.a.C20.3_T2 1.679209e-02 -5.474501e-03 -6.932282e-03 4.182618e-03
## lysoPC.a.C20.4_T2 2.233838e-02 4.602703e-03 1.012627e-02 -1.208096e-02
## lysoPC.a.C24.0_T2 2.521468e-03 -1.454099e-02 -2.993237e-03 -2.099184e-03
## lysoPC.a.C26.0_T2 2.314272e-02 3.940453e-02 2.757015e-03 6.353454e-02
## lysoPC.a.C26.1_T2 3.669205e-03 -1.461972e-02 -6.244206e-03 -5.180545e-03
## lysoPC.a.C28.0_T2 7.017750e-02 6.829672e-02 3.719571e-02 -3.808971e-03
## lysoPC.a.C28.1_T2 7.107187e-03 -1.265816e-02 -4.638762e-03 -7.794940e-04
## PC.aa.C24.0_T2 4.792009e-02 1.611711e-04 -1.496589e-03 -4.104744e-02
## PC.aa.C28.1_T2 -2.258037e-03 1.742778e-03 7.092117e-03 -1.395301e-02
## PC.aa.C30.0_T2 -2.257284e-03 -7.089688e-03 -1.561367e-02 -4.578557e-03
## PC.aa.C32.0_T2 -1.661137e-02 4.223363e-02 -3.946283e-02 -2.872698e-02
## PC.aa.C32.1_T2 -1.024004e-02 2.490432e-02 -3.466535e-02 -4.431384e-03
## PC.aa.C32.3_T2 1.468439e-03 -1.434961e-02 -5.246711e-03 -4.469718e-03
## PC.aa.C34.1_T2 -2.412064e-02 7.179342e-02 4.922817e-04 -1.312027e-02
## PC.aa.C34.2_T2 -2.398395e-02 6.458885e-02 2.008649e-02 2.544103e-02
## PC.aa.C34.3_T2 4.525159e-03 2.199950e-02 -4.887854e-03 2.757410e-02
## PC.aa.C34.4_T2 4.276433e-04 -1.386276e-02 -5.283069e-03 -1.829460e-03
## PC.aa.C36.0_T2 1.408847e-02 -7.568838e-04 -1.798447e-03 8.260845e-03
## PC.aa.C36.1_T2 -1.320246e-02 4.004558e-02 2.420103e-02 3.831552e-02
## PC.aa.C36.2_T2 -1.097672e-02 5.296806e-02 4.244622e-02 5.035341e-02
## PC.aa.C36.3_T2 -7.883061e-03 3.470613e-02 -3.594529e-03 2.246660e-02
## PC.aa.C36.4_T2 -6.117462e-02 4.168411e-02 -3.227996e-02 -5.108840e-02
## PC.aa.C36.5_T2 -1.562816e-02 2.784808e-02 -3.803730e-02 -1.854257e-02
## PC.aa.C38.0_T2 3.405639e-04 1.700928e-02 -7.435578e-03 7.176823e-03
## PC.aa.C38.1_T2 3.208236e-02 -2.523213e-02 -3.909691e-03 1.273222e-02
## PC.aa.C38.3_T2 -1.969331e-03 5.004234e-02 -2.832662e-03 1.391324e-02
## PC.aa.C38.4_T2 -3.046920e-02 4.311556e-02 1.295728e-02 2.341789e-03
## PC.aa.C38.5_T2 -2.194054e-02 4.601320e-02 7.204815e-03 -2.232764e-02
## PC.aa.C38.6_T2 -5.865667e-02 9.728755e-02 5.502724e-03 -4.098206e-02
## PC.aa.C40.1_T2 5.417858e-02 3.581962e-02 3.471026e-02 8.593136e-02
## PC.aa.C40.2_T2 3.038402e-02 -3.411823e-03 -1.051319e-02 9.636587e-03
## PC.aa.C40.3_T2 2.418455e-02 -5.609226e-03 -9.403537e-03 4.191854e-03
## PC.aa.C40.4_T2 2.630906e-02 5.646747e-03 8.326972e-03 7.019310e-03
## PC.aa.C40.5_T2 1.564386e-03 1.596877e-02 9.921107e-03 -1.055617e-03
## PC.aa.C40.6_T2 -3.603300e-02 8.247443e-02 1.434684e-02 -4.994244e-03
## PC.aa.C42.0_T2 7.115705e-03 -1.191451e-02 -6.953877e-03 2.351273e-03
## PC.aa.C42.1_T2 6.158132e-03 -1.346536e-02 -6.127439e-03 5.922023e-04
## PC.aa.C42.2_T2 1.484610e-02 -1.043891e-02 -4.496974e-03 -2.062524e-03
## PC.aa.C42.4_T2 1.320982e-02 -1.065920e-02 -4.646656e-03 -1.215163e-03
## PC.aa.C42.5_T2 6.680523e-03 -1.147817e-02 -4.461174e-03 -2.857915e-03
## PC.aa.C42.6_T2 1.996814e-02 4.411738e-02 1.493972e-02 -5.713965e-04
## PC.ae.C30.0_T2 3.344044e-02 5.892940e-03 -7.509632e-03 7.031713e-03
## PC.ae.C32.1_T2 -1.816300e-03 -1.007400e-02 -1.102167e-03 -4.259471e-03
## PC.ae.C32.2_T2 2.381175e-03 -1.171621e-02 -1.992898e-03 -4.359325e-03
## PC.ae.C34.0_T2 5.582478e-04 -1.256390e-02 -3.668750e-03 -5.859613e-03
## PC.ae.C34.1_T2 -2.985953e-04 1.197044e-02 2.199209e-03 -1.768993e-03
## PC.ae.C34.2_T2 5.129224e-04 1.072902e-02 2.740043e-02 1.067954e-02
## PC.ae.C34.3_T2 -1.300180e-03 8.174920e-03 3.433070e-02 1.316832e-02
## PC.ae.C36.0_T2 4.867268e-03 -5.772549e-03 -2.255814e-03 -4.840174e-03
## PC.ae.C36.1_T2 7.044954e-02 3.139541e-02 -7.032701e-03 2.285183e-02
## PC.ae.C36.2_T2 1.700228e-02 1.895934e-02 2.429909e-02 1.517971e-02
## PC.ae.C36.3_T2 -1.330701e-03 -3.871002e-03 8.505231e-03 1.221621e-02
## PC.ae.C36.4_T2 -1.206516e-02 3.448680e-05 9.839231e-03 6.630659e-03
## PC.ae.C36.5_T2 -1.529576e-02 1.811101e-03 1.269579e-02 2.510083e-03
## PC.ae.C38.0_T2 2.152600e-03 1.407403e-03 -2.567785e-03 -5.155444e-03
## PC.ae.C38.2_T2 6.184151e-02 1.645891e-02 -2.053148e-03 2.334096e-02
## PC.ae.C38.3_T2 6.958746e-02 2.055900e-02 -8.981885e-03 1.317036e-02
## PC.ae.C38.4_T2 -4.858352e-03 4.199892e-03 7.550304e-03 -1.992471e-03
## PC.ae.C38.5_T2 -2.245176e-02 1.581575e-02 -2.724343e-04 8.627956e-03
## PC.ae.C38.6_T2 -1.416607e-02 8.489767e-03 1.292476e-04 2.397077e-03
## PC.ae.C40.1_T2 2.618671e-02 -2.334381e-06 -3.587997e-03 4.106083e-03
## PC.ae.C40.2_T2 2.075903e-02 1.629994e-03 -7.748417e-03 -1.420783e-04
## PC.ae.C40.3_T2 6.288411e-02 1.382446e-02 -5.954528e-03 1.386434e-02
## PC.ae.C40.4_T2 3.725597e-02 3.616552e-03 1.250103e-03 4.348071e-03
## PC.ae.C40.5_T2 5.241610e-02 2.138607e-02 5.258925e-03 -5.391652e-03
## PC.ae.C40.6_T2 -3.626280e-03 4.752329e-03 3.786571e-03 -6.588993e-03
## PC.ae.C42.1_T2 1.789557e-02 -9.265420e-03 -7.450293e-03 5.251726e-03
## PC.ae.C42.2_T2 1.548579e-02 -1.068046e-02 -7.401324e-03 2.925121e-03
## PC.ae.C42.3_T2 2.289089e-02 -4.500102e-03 -1.418794e-03 3.917259e-04
## PC.ae.C42.4_T2 9.786602e-03 -1.231603e-02 -9.382795e-04 -1.052683e-03
## PC.ae.C42.5_T2 2.097016e-02 -1.684919e-03 -2.401746e-03 6.243628e-03
## PC.ae.C44.3_T2 4.489241e-02 5.319532e-03 1.677958e-03 6.267753e-02
## PC.ae.C44.4_T2 4.575337e-03 -1.649072e-02 -4.433444e-03 -2.019262e-03
## PC.ae.C44.5_T2 2.689887e-04 -1.850295e-02 -7.228189e-03 6.827175e-03
## PC.ae.C44.6_T2 2.281602e-03 -2.003565e-02 -5.540281e-03 9.672714e-03
## SM..OH..C14.1_T2 -3.128806e-03 7.491248e-03 2.846838e-02 -2.012743e-02
## SM..OH..C16.1_T2 -2.337047e-03 -1.996498e-03 3.425147e-03 -1.401822e-02
## SM..OH..C22.1_T2 -1.460378e-02 1.283401e-02 2.095862e-02 -1.166198e-02
## SM..OH..C22.2_T2 1.103739e-02 2.124836e-02 2.330506e-02 -1.459678e-02
## SM..OH..C24.1_T2 -1.506632e-03 -1.132405e-02 -4.409095e-03 -4.372059e-03
## SM.C16.0_T2 -2.953034e-02 6.955873e-02 2.968863e-02 -1.429604e-02
## SM.C16.1_T2 -2.176239e-02 4.520771e-02 2.844724e-02 -1.435402e-02
## SM.C18.0_T2 -3.193996e-02 5.061410e-02 -2.953849e-02 -5.102235e-02
## SM.C18.1_T2 -2.472939e-02 3.823218e-02 6.380900e-03 -3.559307e-02
## SM.C20.2_T2 3.941159e-04 -1.496786e-02 -7.424851e-03 -3.102055e-03
## SM.C24.0_T2 -2.343616e-02 3.750628e-02 1.502857e-02 -2.759474e-03
## SM.C24.1_T2 -2.394161e-02 6.834633e-02 -9.549456e-03 -1.125271e-02
## MEDDM_T4 6.221103e-04 -1.705296e-02 -4.746287e-03 -1.258012e-02
## MEDCOL_T4 -1.279878e-03 -1.462806e-02 -4.335024e-03 -5.317345e-03
## MEDINF_T4 -1.077442e-03 -1.600652e-02 -9.408243e-03 -4.101081e-03
## MEDHTA_T4 -7.630148e-04 -2.206942e-02 -8.189762e-03 5.209798e-04
## GLU_T4 -2.335043e-02 -7.303913e-02 3.325266e-02 -4.895984e-02
## INS_T4 6.262207e-03 -7.832525e-02 -8.589785e-02 -1.552017e-02
## HOMA_T4 -2.913690e-03 -4.379960e-02 -3.602175e-02 -9.687979e-03
## HBA1C_T4 -3.063996e-03 -6.986846e-02 2.777070e-02 -3.937712e-02
## HBA1C.mmol.mol_T4 -7.227177e-03 -9.957181e-02 6.688474e-02 -7.666988e-02
## PESO_T4 -5.581687e-03 -1.113947e-01 -8.267917e-02 -1.958222e-02
## bmi_T4 -6.284647e-03 -9.656870e-02 -4.804764e-02 -5.061252e-02
## CC_T4 -4.927665e-04 -2.135734e-02 -4.243705e-04 -1.795031e-03
## CINT_T4 -2.542294e-03 -9.694827e-02 -3.110850e-02 -1.952803e-02
## CAD_T4 -3.078503e-03 -8.988065e-02 -1.714567e-02 -7.752544e-02
## TAD_T4 -1.051695e-02 -3.504618e-02 8.120200e-03 -5.891459e-02
## TAS_T4 -3.017671e-02 -5.098324e-02 5.464420e-03 -5.655045e-02
## TG_T4 -4.312488e-02 5.874859e-02 -7.270923e-02 -7.012975e-02
## COL_T4 -3.381578e-02 4.722974e-02 6.574965e-02 -6.535415e-02
## LDL_T4 -2.136601e-02 5.759097e-02 2.882439e-02 -5.418709e-02
## HDL_T4 -2.386914e-02 -9.187241e-03 1.784191e-01 -7.362755e-03
## VLDL_T4 -5.363939e-03 6.989135e-02 -6.740415e-02 -8.616311e-02
## PCR_T4 -8.291790e-02 -4.313247e-02 -4.297700e-03 -1.222779e-02
## LEP_T4 -5.003410e-02 -9.852481e-03 -2.310543e-02 -3.564679e-02
## ADIPO_T4 8.887434e-02 -2.827812e-02 1.045157e-01 -1.467068e-01
## GOT_T4 7.457260e-02 -8.108751e-02 3.989564e-02 -9.971311e-04
## GPT_T4 3.503376e-02 -9.067913e-02 -2.791009e-02 -6.942741e-03
## GGT_T4 -1.079355e-02 1.347402e-02 -1.209469e-02 5.379085e-02
## URICO_T4 1.216507e-02 -7.685507e-02 -6.200506e-02 -3.406470e-02
## CREAT_T4 3.378724e-04 -2.445086e-02 -8.398565e-03 -9.871337e-03
## UREA_T4 8.528855e-03 -5.255088e-02 1.295444e-01 4.712962e-02
## HIERRO_T4 -1.662116e-02 1.615284e-02 5.311776e-04 -1.093656e-01
## TRANSF_T4 -3.037808e-02 -2.602045e-02 4.948900e-02 4.605902e-03
## FERR_T4 2.197843e-02 -8.527818e-02 -2.604519e-02 1.790478e-02
## Ile_T4 6.543982e-02 5.926885e-03 -7.198042e-02 -2.585782e-02
## Leu_T4 5.069705e-02 -5.163313e-03 -6.172129e-02 -5.965764e-03
## Val_T4 2.705059e-02 1.359068e-02 -2.942072e-02 -1.671233e-02
## Ala_T4 3.727865e-02 3.287996e-02 -5.343688e-02 1.735262e-02
## Pro_T4 3.423316e-02 3.056576e-02 1.449866e-02 3.752052e-02
## Gly_T4 8.064635e-02 4.319920e-02 2.923927e-02 -3.900687e-02
## Ser_T4 1.068991e-02 -5.360095e-04 2.055315e-02 -1.833503e-02
## Trp_T4 -6.711082e-03 -8.434375e-03 -1.371399e-02 5.703897e-02
## Phe_T4 5.878263e-02 1.152045e-02 -7.751260e-03 -3.971354e-03
## Met_T4 -1.571397e-02 -3.681075e-02 1.401116e-03 -2.851400e-02
## Orn_T4 4.259717e-02 1.855289e-02 6.309745e-02 3.943508e-02
## Arg_T4 3.475179e-02 3.817134e-02 1.042684e-04 -3.191402e-02
## His_T4 6.035623e-02 1.428180e-02 2.091095e-02 -3.206589e-02
## Asn_T4 4.563756e-02 -7.671654e-03 7.756611e-03 1.896251e-02
## Asp_T4 4.927814e-02 1.872835e-03 -5.607167e-03 2.995203e-02
## Glu_T4 6.366851e-02 5.005528e-02 5.878442e-03 2.707172e-02
## Gln_T4 -3.129997e-02 -1.168173e-01 3.990498e-02 -2.741574e-02
## Cit_T4 1.129950e-02 1.543412e-02 4.084034e-02 -3.487535e-03
## Tyr_T4 3.542797e-02 7.505496e-03 -2.542831e-03 4.446905e-02
## Thr_T4 3.370749e-02 1.114443e-02 2.791434e-02 3.492639e-02
## Lys_T4 3.838280e-02 -2.497339e-02 -2.867644e-02 -3.597825e-02
## Creatinine_T4 3.309588e-02 1.104996e-02 -5.124964e-02 -3.218996e-02
## Kynurenine_T4 2.106531e-02 -1.394489e-02 -3.474016e-02 7.061174e-02
## Putrescine_T4 -8.483349e-02 1.529647e-02 -5.026553e-02 1.190210e-01
## Sarcosine_T4 -1.177845e-02 -3.288678e-02 -3.811990e-02 7.868818e-02
## Serotonin_T4 -4.284880e-03 -4.406096e-03 -4.100236e-02 -4.564248e-02
## Taurine_T4 -8.950146e-03 -7.928578e-02 4.921781e-02 -2.440191e-02
## SDMA_T4 3.687367e-03 -7.157059e-03 -1.148116e-02 -6.233502e-03
## C0_T4 -5.141620e-03 2.045451e-02 2.580952e-02 2.051326e-02
## C2_T4 1.784705e-02 1.161645e-02 -4.414147e-02 -5.831901e-02
## C3.OH_T4 7.054105e-04 -1.895762e-02 -4.814558e-03 -3.414600e-03
## C6..C4.1.DC._T4 -9.159270e-02 -3.639221e-02 -4.041502e-02 9.696004e-02
## C5.DC..C6.OH._T4 2.287131e-03 -1.252604e-02 1.462209e-02 2.657713e-02
## C7.DC_T4 1.676911e-02 -1.226962e-02 6.814039e-03 4.522521e-03
## C8_T4 2.049179e-03 -2.013561e-02 -4.256355e-03 -4.126333e-03
## C10_T4 4.748747e-03 -1.757094e-02 -3.597221e-03 -5.067743e-03
## C10.1_T4 2.951269e-03 -1.834806e-02 -4.631755e-03 -3.266517e-03
## C10.2_T4 2.915242e-04 -1.767538e-02 -4.867431e-03 -1.801703e-03
## C14.1_T4 1.352338e-03 -1.712699e-02 -5.719900e-03 -5.573397e-03
## C14.2_T4 8.748731e-04 -1.744915e-02 -5.186923e-03 -3.217442e-03
## C16.1_T4 -4.802218e-03 1.706512e-03 4.550589e-02 -8.860807e-03
## C16.2_T4 4.153818e-04 -1.671166e-02 -5.930076e-03 -3.482852e-03
## C16.2.OH_T4 -4.855219e-03 1.592772e-03 4.493913e-02 -8.718487e-03
## C18.1_T4 1.489636e-03 -1.580470e-02 -6.624890e-03 -5.587097e-03
## C18.1.OH_T4 5.327879e-04 -1.689038e-02 -5.554705e-03 -3.282125e-03
## C18.2_T4 7.599482e-04 -1.704478e-02 -5.220560e-03 -3.241188e-03
## lysoPC.a.C16.0_T4 5.121107e-02 7.177351e-02 -6.433101e-03 -1.512495e-02
## lysoPC.a.C16.1_T4 4.814257e-02 3.372299e-02 -7.522975e-03 -1.211151e-02
## lysoPC.a.C17.0_T4 2.472207e-02 3.021292e-03 1.075846e-02 -1.401078e-02
## lysoPC.a.C18.0_T4 5.044986e-02 6.161521e-02 5.457132e-02 6.720166e-03
## lysoPC.a.C18.1_T4 5.704308e-02 6.094733e-02 1.642761e-02 -4.281159e-02
## lysoPC.a.C18.2_T4 5.740298e-02 -5.790233e-03 4.470806e-02 5.948071e-04
## lysoPC.a.C20.3_T4 1.076509e-02 1.195988e-03 -1.496281e-02 -1.061877e-02
## lysoPC.a.C20.4_T4 4.276114e-02 3.096234e-02 -3.870057e-02 -6.418373e-02
## lysoPC.a.C24.0_T4 3.073208e-03 -1.730292e-02 -4.485640e-03 -2.884361e-03
## lysoPC.a.C26.0_T4 2.253355e-02 2.152669e-02 -2.563499e-02 1.470922e-02
## lysoPC.a.C26.1_T4 2.694835e-03 -1.483558e-02 -5.639067e-03 -2.672828e-03
## lysoPC.a.C28.0_T4 2.424564e-02 4.551225e-03 -1.081909e-02 5.637048e-02
## lysoPC.a.C28.1_T4 6.121849e-03 -1.263217e-02 -3.313464e-03 -1.035523e-03
## PC.aa.C24.0_T4 2.262053e-02 3.122511e-02 -1.725024e-02 4.618926e-02
## PC.aa.C28.1_T4 2.529209e-03 6.709833e-04 1.005991e-02 -7.491789e-03
## PC.aa.C30.0_T4 4.828646e-03 -1.120518e-03 -1.796308e-02 -1.577906e-03
## PC.aa.C32.0_T4 2.773994e-02 8.742806e-02 -5.272916e-02 -1.707745e-02
## PC.aa.C32.1_T4 1.250721e-02 8.838460e-02 -3.227590e-02 2.784093e-02
## PC.aa.C32.3_T4 1.584270e-03 -1.381786e-02 -4.848805e-03 -3.628922e-03
## PC.aa.C34.1_T4 -7.739405e-03 1.226862e-01 -2.378326e-02 -1.623161e-02
## PC.aa.C34.2_T4 -1.050548e-02 7.313568e-02 4.059138e-03 1.255993e-02
## PC.aa.C34.3_T4 -4.237827e-03 4.912400e-02 2.700112e-02 2.639334e-02
## PC.aa.C34.4_T4 -2.372289e-03 -1.199562e-02 -5.594563e-03 6.523612e-04
## PC.aa.C36.0_T4 1.056348e-02 8.040621e-03 8.857315e-03 3.155503e-03
## PC.aa.C36.1_T4 -4.853587e-02 8.863772e-02 3.882958e-02 3.827715e-02
## PC.aa.C36.2_T4 -3.864676e-02 6.195056e-02 5.833934e-02 6.176635e-02
## PC.aa.C36.3_T4 -4.622997e-02 8.342419e-02 -5.710335e-03 4.040688e-02
## PC.aa.C36.4_T4 -1.250613e-02 9.577756e-02 -6.300606e-02 -1.884866e-02
## PC.aa.C36.5_T4 -3.147602e-02 6.800822e-02 -2.056615e-02 -1.076283e-03
## PC.aa.C38.0_T4 -1.271027e-03 3.186359e-02 7.769639e-03 5.174960e-03
## PC.aa.C38.1_T4 1.431643e-02 1.496266e-02 1.484004e-03 3.358954e-03
## PC.aa.C38.3_T4 -4.019321e-02 1.009897e-01 -1.306164e-02 5.102613e-02
## PC.aa.C38.4_T4 -2.762959e-02 9.572786e-02 -3.111845e-02 1.860275e-02
## PC.aa.C38.5_T4 -2.445981e-02 1.092561e-01 -3.035773e-02 -1.520907e-02
## PC.aa.C38.6_T4 -3.976156e-02 1.161441e-01 -2.856020e-02 -2.705500e-02
## PC.aa.C40.1_T4 3.734444e-02 4.698770e-02 6.506392e-03 2.205278e-02
## PC.aa.C40.2_T4 2.635762e-02 1.129636e-03 3.073795e-03 -1.863949e-03
## PC.aa.C40.3_T4 2.113096e-02 2.412896e-03 9.991507e-04 -1.754358e-03
## PC.aa.C40.4_T4 2.783414e-02 2.153183e-02 8.284951e-03 6.439017e-03
## PC.aa.C40.5_T4 -6.780948e-03 5.739093e-02 -1.462312e-02 4.327099e-03
## PC.aa.C40.6_T4 -4.344218e-02 1.087207e-01 -1.447058e-02 -1.103246e-02
## PC.aa.C42.0_T4 6.296538e-03 -8.657984e-03 -3.562393e-03 -1.602326e-03
## PC.aa.C42.1_T4 6.544875e-03 -1.114046e-02 -3.810689e-03 -1.921457e-03
## PC.aa.C42.2_T4 1.236289e-02 -8.144499e-03 -4.522907e-04 -6.254228e-03
## PC.aa.C42.4_T4 1.430619e-02 -8.063084e-03 5.862469e-04 -4.519321e-03
## PC.aa.C42.5_T4 6.171514e-03 -7.397710e-03 -4.726447e-03 -3.228396e-03
## PC.aa.C42.6_T4 1.434618e-02 1.573248e-02 -9.302576e-03 3.748314e-02
## PC.ae.C30.0_T4 1.476514e-02 4.263130e-02 1.181647e-02 4.249945e-03
## PC.ae.C32.1_T4 1.118356e-02 3.837654e-03 -2.766908e-03 -6.171587e-03
## PC.ae.C32.2_T4 6.153218e-03 -6.410174e-03 -3.992508e-03 -5.453986e-03
## PC.ae.C34.0_T4 2.179413e-03 -1.218479e-02 -5.208531e-03 -5.132130e-03
## PC.ae.C34.1_T4 -2.327206e-04 3.447648e-02 -5.272682e-04 -8.623733e-03
## PC.ae.C34.2_T4 7.819869e-03 2.604721e-02 5.200774e-02 5.487904e-03
## PC.ae.C34.3_T4 1.518003e-02 1.510617e-02 3.798394e-02 4.350871e-03
## PC.ae.C36.0_T4 4.670864e-03 -6.028202e-03 -2.119175e-03 -7.292384e-03
## PC.ae.C36.1_T4 7.921180e-02 5.695052e-02 5.009061e-02 -3.983171e-02
## PC.ae.C36.2_T4 8.465069e-03 3.295427e-02 4.840333e-02 7.954082e-04
## PC.ae.C36.3_T4 -5.425292e-03 6.361628e-03 2.665651e-02 1.638287e-02
## PC.ae.C36.4_T4 -1.336785e-02 2.596308e-02 1.075799e-02 1.711794e-02
## PC.ae.C36.5_T4 -6.016467e-03 3.200970e-02 8.579059e-03 1.127039e-02
## PC.ae.C38.0_T4 -5.724563e-03 9.901465e-03 -1.501623e-03 -4.189372e-03
## PC.ae.C38.2_T4 7.826863e-02 3.701886e-02 3.787274e-02 -9.320256e-03
## PC.ae.C38.3_T4 6.469396e-02 4.091143e-02 1.543588e-02 3.876735e-03
## PC.ae.C38.4_T4 -2.321748e-03 2.000925e-02 6.869525e-03 6.784508e-03
## PC.ae.C38.5_T4 -1.349853e-02 3.611045e-02 6.419068e-03 1.618844e-02
## PC.ae.C38.6_T4 -1.652951e-02 2.068113e-02 1.173129e-02 5.346097e-03
## PC.ae.C40.1_T4 1.627970e-02 5.313140e-03 6.054934e-03 4.178487e-05
## PC.ae.C40.2_T4 2.914961e-02 1.233505e-02 -1.494000e-03 -5.972933e-03
## PC.ae.C40.3_T4 6.497773e-02 2.926602e-02 1.589755e-02 8.522216e-04
## PC.ae.C40.4_T4 4.842871e-02 2.006119e-02 1.564379e-02 -1.418520e-03
## PC.ae.C40.5_T4 6.573000e-02 3.924799e-02 2.030707e-02 -1.807145e-02
## PC.ae.C40.6_T4 -5.342771e-03 1.101446e-02 1.659878e-03 -4.951780e-03
## PC.ae.C42.1_T4 1.395189e-02 -4.227097e-03 -8.699923e-04 -1.324381e-04
## PC.ae.C42.2_T4 1.026979e-02 -8.269396e-03 1.884920e-04 -8.149770e-04
## PC.ae.C42.3_T4 2.066689e-02 -2.015175e-03 7.682697e-03 -7.274655e-03
## PC.ae.C42.4_T4 1.111241e-02 -1.055521e-02 6.923911e-03 1.121604e-03
## PC.ae.C42.5_T4 3.459445e-02 1.199763e-02 3.987607e-04 -1.645389e-02
## PC.ae.C44.3_T4 9.049013e-03 -1.192936e-02 -1.099771e-03 -5.020693e-03
## PC.ae.C44.4_T4 4.294970e-03 -1.532038e-02 -2.566633e-03 -4.929617e-03
## PC.ae.C44.5_T4 3.222760e-03 -1.434472e-02 -1.086216e-02 -4.559887e-03
## PC.ae.C44.6_T4 6.820969e-03 -2.018065e-02 -4.071994e-03 3.479071e-04
## SM..OH..C14.1_T4 6.848421e-03 3.621023e-03 3.348323e-03 -3.866911e-02
## SM..OH..C16.1_T4 3.716071e-03 -4.686472e-03 -1.134484e-02 -2.325436e-02
## SM..OH..C22.1_T4 -4.151286e-02 -2.791574e-03 1.215903e-02 -6.981507e-03
## SM..OH..C22.2_T4 -1.095592e-03 2.375439e-02 2.135809e-02 -2.696514e-02
## SM..OH..C24.1_T4 -2.392746e-03 -1.511789e-02 -6.669545e-03 -4.195342e-03
## SM.C16.0_T4 -1.278910e-02 6.332065e-02 -2.274655e-02 -3.649563e-02
## SM.C16.1_T4 1.136336e-02 4.342851e-02 2.267820e-03 -4.960311e-02
## SM.C18.0_T4 3.942216e-03 6.945102e-02 -8.990950e-02 -6.874163e-02
## SM.C18.1_T4 1.761095e-02 5.892245e-02 -3.208513e-02 -7.174301e-02
## SM.C20.2_T4 1.036226e-03 -1.361141e-02 -7.427236e-03 -3.264413e-03
## SM.C24.0_T4 -5.001151e-02 1.702962e-02 1.843063e-02 2.425378e-02
## SM.C24.1_T4 -2.457752e-02 8.751003e-02 -4.356497e-02 -2.877841e-02
## MEDDM_T5 1.541726e-03 -2.849761e-02 -2.993495e-03 -1.568098e-02
## MEDCOL_T5 1.541726e-03 -2.849761e-02 -2.993495e-03 -1.568098e-02
## MEDINF_T5 3.187324e-04 -2.830269e-02 -8.097097e-03 -1.609873e-02
## MEDHTA_T5 1.631254e-03 -2.884248e-02 -2.306314e-03 -2.553045e-02
## GLU_T5 -5.527453e-02 -2.476306e-02 4.620418e-02 -8.763713e-02
## INS_T5 -4.071259e-03 -7.052698e-03 -1.010909e-01 -1.985246e-02
## HOMA_T5 -6.458594e-03 -1.875732e-02 -3.615516e-02 -1.173150e-02
## HBA1C_T5 -4.985002e-03 -6.739199e-02 3.365910e-02 -3.980743e-02
## HBA1C.mmol.mol_T5 -1.389622e-02 -9.161159e-02 8.775688e-02 -7.883002e-02
## PESO_T5 -2.179200e-02 -1.743265e-02 -8.966485e-02 -2.569118e-02
## bmi_T5 -2.150532e-02 6.569099e-04 -5.662520e-02 -3.639503e-02
## CC_T5 7.249484e-05 -2.415086e-02 -3.209995e-03 -4.924151e-03
## CINT_T5 -2.481676e-02 9.062593e-03 -6.193861e-02 -2.112038e-02
## CAD_T5 -2.543660e-02 1.344483e-02 -3.063541e-02 -8.651131e-02
## TAD_T5 -9.652439e-03 -6.385695e-02 6.541223e-02 -4.907469e-02
## TAS_T5 -5.731885e-04 -8.874218e-02 5.653855e-02 -5.204994e-03
## TG_T5 -5.063651e-02 9.927692e-02 -2.358428e-02 -9.542054e-02
## COL_T5 -6.630115e-02 7.337893e-02 8.637781e-02 -7.195214e-02
## LDL_T5 -5.459825e-02 7.575803e-02 5.339063e-02 -5.157834e-02
## HDL_T5 -2.128401e-02 1.008567e-02 1.538598e-01 -5.010872e-02
## VLDL_T5 -3.610009e-02 7.916395e-02 -4.088093e-02 -5.943094e-02
## PCR_T5 -5.089461e-02 8.309171e-03 -1.656186e-02 -8.089484e-03
## LEP_T5 -4.461574e-02 3.865464e-02 -4.633159e-03 -7.178361e-02
## ADIPO_T5 8.287738e-02 -1.397499e-02 1.188456e-01 -1.440083e-01
## GOT_T5 7.650004e-02 -4.735164e-02 2.626216e-02 -3.511994e-02
## GPT_T5 3.879732e-02 -7.825684e-02 -4.833914e-02 -4.640349e-02
## GGT_T5 1.371071e-02 4.304554e-02 -1.870616e-02 -1.201446e-02
## URICO_T5 1.750099e-03 -1.531693e-02 -4.368160e-02 -1.074753e-02
## CREAT_T5 1.526487e-04 -1.710771e-02 -8.572132e-03 -1.079947e-02
## UREA_T5 1.438625e-03 -2.261755e-02 7.992962e-02 4.763995e-02
## HIERRO_T5 2.410971e-03 -8.427796e-02 6.709630e-02 -2.060320e-03
## TRANSF_T5 -4.065783e-02 3.554980e-02 3.069176e-02 -6.478675e-03
## FERR_T5 7.311036e-03 -8.570257e-02 -4.028338e-02 -2.009189e-02
## Ile_T5 6.129890e-02 -1.666252e-02 -5.840193e-02 6.039952e-02
## Leu_T5 6.038558e-02 -4.559871e-02 -7.763930e-03 6.181194e-02
## Val_T5 4.059724e-02 -3.210582e-02 -4.171412e-03 7.112565e-02
## Ala_T5 3.978706e-02 1.317591e-02 -4.460490e-03 -2.495122e-03
## Pro_T5 6.525215e-02 -2.058756e-02 -2.213686e-02 3.287735e-02
## Gly_T5 6.657912e-02 1.914752e-02 4.520885e-02 -4.569807e-03
## Ser_T5 7.261378e-02 -2.481652e-02 -5.150885e-03 -4.236959e-02
## Trp_T5 8.324534e-03 -5.162927e-02 1.447775e-02 1.236680e-01
## Phe_T5 7.489163e-02 -1.366845e-02 2.949598e-02 2.778611e-02
## Met_T5 -1.800008e-02 -7.305444e-02 -2.840993e-02 8.711630e-02
## Orn_T5 1.019141e-01 -4.146962e-03 8.377865e-02 5.465269e-02
## Arg_T5 4.046660e-02 4.062245e-03 5.737180e-03 3.295377e-02
## His_T5 8.287990e-02 -2.552736e-02 3.708990e-02 -2.721187e-02
## Asn_T5 8.112528e-02 -3.836674e-02 -1.530230e-02 7.068078e-03
## Asp_T5 9.374592e-02 5.220115e-02 1.615056e-02 8.300922e-02
## Glu_T5 5.834101e-02 4.788402e-02 7.269412e-03 3.781849e-02
## Gln_T5 4.361097e-02 -6.386021e-02 -3.539830e-02 -1.811416e-02
## Cit_T5 1.036185e-01 -1.999110e-02 3.933326e-02 1.879824e-02
## Tyr_T5 7.664697e-02 -2.220519e-02 2.846423e-02 4.788779e-02
## Thr_T5 9.804510e-03 -2.324482e-02 1.268395e-02 6.584655e-02
## Lys_T5 1.077291e-02 1.167722e-02 1.186584e-02 5.304529e-02
## Creatinine_T5 2.462916e-02 -1.123241e-01 -7.763835e-02 -3.300848e-02
## Kynurenine_T5 -8.851449e-03 -7.068805e-03 -3.525099e-02 1.367677e-01
## Putrescine_T5 -2.499126e-02 3.659217e-03 -1.232352e-01 -6.563615e-03
## Sarcosine_T5 -1.309200e-03 -8.511145e-02 -7.574182e-02 -3.427045e-02
## Serotonin_T5 5.082634e-03 -6.754399e-03 -5.106285e-02 -4.064373e-02
## Taurine_T5 4.741507e-02 -4.708094e-02 1.418005e-02 2.091455e-02
## SDMA_T5 3.343762e-03 -2.072065e-02 -9.211640e-03 -2.264523e-03
## C0_T5 3.783909e-02 -2.135769e-02 -3.198523e-02 5.584267e-02
## C2_T5 1.585730e-02 -4.506457e-02 -2.991364e-02 5.162807e-03
## C3.OH_T5 7.224460e-04 -1.768228e-02 -4.798772e-03 -4.062188e-03
## C6..C4.1.DC._T5 -1.463326e-02 -3.892352e-02 -6.236010e-03 1.037224e-01
## C5.DC..C6.OH._T5 3.343447e-03 -1.516615e-02 -3.034681e-02 -2.334195e-02
## C7.DC_T5 -9.757712e-03 1.446298e-02 3.266875e-02 -4.915976e-02
## C8_T5 1.766735e-03 -2.036470e-02 -6.958868e-03 -4.334618e-03
## C10_T5 3.071888e-03 -2.052322e-02 -7.761144e-03 -5.174210e-03
## C10.1_T5 6.500279e-02 -2.494447e-02 -1.048334e-02 2.953837e-02
## C10.2_T5 6.744042e-04 -1.788651e-02 -5.670678e-03 -3.795668e-03
## C14.1_T5 1.246695e-03 -1.786041e-02 -5.143623e-03 -3.082646e-03
## C14.2_T5 1.016741e-03 -1.776352e-02 -5.281143e-03 -3.498403e-03
## C16.1_T5 5.211026e-04 -1.722812e-02 -5.016716e-03 -3.038556e-03
## C16.2_T5 5.672111e-04 -1.686587e-02 -5.538483e-03 -3.032647e-03
## C16.2.OH_T5 1.053338e-02 -2.164978e-02 -2.190764e-02 2.292170e-02
## C18.1_T5 1.956490e-03 -1.704430e-02 -5.771966e-03 -3.042850e-03
## C18.1.OH_T5 4.442292e-04 -1.668763e-02 -5.399711e-03 -2.942755e-03
## C18.2_T5 9.834848e-04 -1.718802e-02 -5.762315e-03 -2.680992e-03
## lysoPC.a.C16.0_T5 7.080223e-02 3.813469e-03 -4.165594e-02 -3.730536e-02
## lysoPC.a.C16.1_T5 6.900519e-02 -1.341190e-02 -1.066626e-02 -6.450577e-02
## lysoPC.a.C17.0_T5 2.487366e-02 -2.280832e-02 6.208461e-03 -1.254888e-02
## lysoPC.a.C18.0_T5 7.257095e-02 2.097141e-02 1.917232e-02 -9.816001e-03
## lysoPC.a.C18.1_T5 8.201356e-02 -1.183655e-03 -3.310276e-02 -5.780339e-02
## lysoPC.a.C18.2_T5 7.123098e-02 -5.169550e-02 -5.141749e-02 -1.626370e-02
## lysoPC.a.C20.3_T5 3.758766e-02 -1.500908e-02 -4.541578e-02 -1.344349e-02
## lysoPC.a.C20.4_T5 5.087245e-02 -2.825781e-02 -9.560753e-02 -1.624428e-02
## lysoPC.a.C24.0_T5 5.029244e-03 -1.724646e-02 -1.178378e-03 -6.888565e-03
## lysoPC.a.C26.0_T5 1.097507e-02 -1.018114e-02 -1.067626e-03 -8.000479e-03
## lysoPC.a.C26.1_T5 3.042777e-03 -1.463654e-02 -5.990520e-03 -3.808208e-03
## lysoPC.a.C28.0_T5 3.751754e-02 2.688244e-02 4.180641e-02 6.088762e-02
## lysoPC.a.C28.1_T5 4.852821e-03 -1.441850e-02 -3.722307e-03 -5.420191e-03
## PC.aa.C24.0_T5 1.902667e-02 1.029317e-01 5.592628e-03 2.327887e-02
## PC.aa.C28.1_T5 3.609349e-03 -1.163538e-02 6.425658e-03 1.036317e-02
## PC.aa.C30.0_T5 2.100091e-03 -9.604424e-03 -9.927398e-03 4.992370e-04
## PC.aa.C32.0_T5 4.776583e-02 1.800694e-02 -5.971899e-02 4.332068e-03
## PC.aa.C32.1_T5 3.429672e-02 3.630285e-02 1.533203e-03 -5.482252e-02
## PC.aa.C32.3_T5 1.614148e-03 -1.547499e-02 -4.610883e-03 -3.613500e-03
## PC.aa.C34.1_T5 2.761893e-02 5.089718e-02 -1.950930e-02 -3.673821e-02
## PC.aa.C34.2_T5 1.135867e-02 3.844365e-02 -1.530700e-02 1.639475e-02
## PC.aa.C34.3_T5 1.254723e-02 3.725922e-02 -8.986230e-04 1.708291e-03
## PC.aa.C34.4_T5 3.564734e-04 -1.414360e-02 -6.706927e-03 7.095643e-04
## PC.aa.C36.0_T5 1.467368e-02 1.637358e-03 9.001790e-03 -9.223767e-03
## PC.aa.C36.1_T5 4.375246e-02 3.868550e-02 6.665434e-02 2.779955e-02
## PC.aa.C36.2_T5 1.135660e-02 3.634538e-02 3.571460e-02 5.005929e-02
## PC.aa.C36.3_T5 7.302783e-03 3.804636e-02 -1.758279e-02 3.697830e-02
## PC.aa.C36.4_T5 -4.911345e-03 3.422378e-02 -7.179767e-02 3.182023e-02
## PC.aa.C36.5_T5 -2.951559e-02 1.929588e-02 -5.366847e-02 1.963963e-03
## PC.aa.C38.0_T5 7.425625e-03 8.548694e-03 1.915956e-02 1.425086e-03
## PC.aa.C38.1_T5 2.500377e-02 -6.390971e-03 1.614475e-02 -1.185600e-02
## PC.aa.C38.3_T5 8.581703e-03 5.881153e-02 -5.618626e-03 7.608727e-02
## PC.aa.C38.4_T5 -1.115337e-03 4.528570e-02 -2.464253e-02 5.377187e-02
## PC.aa.C38.5_T5 -2.278655e-03 4.950092e-02 -4.418336e-02 7.951087e-03
## PC.aa.C38.6_T5 -3.171722e-02 5.052549e-02 -4.403237e-02 9.278388e-03
## PC.aa.C40.1_T5 5.057646e-02 5.337592e-02 3.727134e-02 7.253678e-02
## PC.aa.C40.2_T5 2.390378e-02 -3.401774e-03 8.249943e-03 -1.236759e-02
## PC.aa.C40.3_T5 2.484305e-02 -3.321701e-03 9.327076e-03 -1.591358e-02
## PC.aa.C40.4_T5 2.942227e-02 1.020356e-02 3.484427e-03 -5.326501e-03
## PC.aa.C40.5_T5 1.472309e-02 2.495197e-02 -9.886069e-03 -3.718390e-03
## PC.aa.C40.6_T5 -2.198015e-02 5.577399e-02 -2.221719e-02 3.176114e-02
## PC.aa.C42.0_T5 5.582795e-03 -1.524493e-02 -1.339190e-03 -2.416744e-03
## PC.aa.C42.1_T5 4.445405e-03 -1.500554e-02 -2.067898e-03 -3.272964e-03
## PC.aa.C42.2_T5 1.134628e-02 -1.060588e-02 1.387126e-03 -9.011786e-03
## PC.aa.C42.4_T5 1.436200e-02 -9.078345e-03 1.910065e-03 -8.276968e-03
## PC.aa.C42.5_T5 8.337280e-03 -1.023938e-02 -3.132676e-03 -5.857119e-03
## PC.aa.C42.6_T5 3.059907e-02 1.772433e-02 3.327346e-02 4.770274e-02
## PC.ae.C30.0_T5 4.123809e-02 2.551173e-03 3.011578e-03 6.151764e-02
## PC.ae.C32.1_T5 1.464275e-02 -1.881502e-02 4.605090e-03 -3.990791e-03
## PC.ae.C32.2_T5 6.155085e-03 -1.396863e-02 5.778248e-04 -4.532878e-03
## PC.ae.C34.0_T5 4.204792e-03 -1.549245e-02 -3.383304e-03 -3.448050e-04
## PC.ae.C34.1_T5 1.500118e-02 4.682033e-03 1.869484e-02 1.162104e-03
## PC.ae.C34.2_T5 2.976525e-02 -3.134157e-03 5.747666e-02 1.428608e-02
## PC.ae.C34.3_T5 3.032804e-02 -4.137577e-04 3.366499e-02 4.786173e-03
## PC.ae.C36.0_T5 1.012804e-02 -1.211150e-02 -1.481114e-04 -4.683142e-03
## PC.ae.C36.1_T5 8.529050e-02 3.366812e-02 5.841114e-02 -3.737904e-02
## PC.ae.C36.2_T5 3.312514e-02 1.130067e-02 5.109737e-02 4.222601e-03
## PC.ae.C36.3_T5 1.091268e-02 -1.171201e-02 2.730497e-02 1.009591e-02
## PC.ae.C36.4_T5 1.211299e-02 -4.213648e-04 5.323768e-03 4.557527e-02
## PC.ae.C36.5_T5 9.455720e-03 9.487964e-03 -4.751863e-03 1.461187e-02
## PC.ae.C38.0_T5 -3.775928e-04 -7.523064e-03 -4.925656e-03 -1.442187e-03
## PC.ae.C38.2_T5 7.961989e-02 2.653794e-02 5.121811e-02 -3.425456e-02
## PC.ae.C38.3_T5 5.944123e-02 2.164338e-02 1.715554e-02 9.669008e-03
## PC.ae.C38.4_T5 2.808046e-03 -5.103262e-03 6.818595e-03 3.817361e-02
## PC.ae.C38.5_T5 -5.304074e-04 4.184585e-03 -1.701410e-02 4.579457e-02
## PC.ae.C38.6_T5 -5.422127e-03 2.228251e-03 4.434281e-04 1.316128e-02
## PC.ae.C40.1_T5 1.752307e-02 -5.276469e-03 6.689195e-04 -9.876361e-03
## PC.ae.C40.2_T5 3.109212e-02 2.143312e-03 7.229232e-03 -7.645975e-03
## PC.ae.C40.3_T5 6.101128e-02 2.036306e-02 1.588517e-02 2.419691e-03
## PC.ae.C40.4_T5 4.657417e-02 4.679170e-03 2.518755e-02 2.294853e-03
## PC.ae.C40.5_T5 5.827443e-02 1.581681e-02 9.322981e-03 2.320437e-03
## PC.ae.C40.6_T5 -1.353030e-05 -1.138217e-02 -5.227260e-03 5.994736e-03
## PC.ae.C42.1_T5 1.483743e-02 -7.959172e-03 6.368443e-05 -6.763585e-03
## PC.ae.C42.2_T5 1.296022e-02 -1.149058e-02 1.594072e-03 -7.583493e-03
## PC.ae.C42.3_T5 2.042069e-02 -6.966034e-03 8.290229e-03 -8.830890e-03
## PC.ae.C42.4_T5 1.466883e-02 -1.394389e-02 6.450968e-03 -1.856290e-03
## PC.ae.C42.5_T5 3.683359e-02 -6.289557e-03 6.145650e-03 1.283623e-02
## PC.ae.C44.3_T5 9.591082e-03 -1.242455e-02 -3.536827e-04 -7.342401e-03
## PC.ae.C44.4_T5 5.611252e-03 -1.649394e-02 1.922577e-04 -2.873987e-03
## PC.ae.C44.5_T5 2.671604e-03 -2.647666e-02 -2.356225e-03 1.437847e-02
## PC.ae.C44.6_T5 6.367906e-03 -2.830281e-02 -2.654624e-03 1.196712e-02
## SM..OH..C14.1_T5 5.134371e-03 -1.587543e-02 1.221979e-02 6.846117e-05
## SM..OH..C16.1_T5 1.238687e-03 -1.691769e-02 -5.327015e-03 -1.637048e-03
## SM..OH..C22.1_T5 -2.926439e-02 1.590346e-02 1.561327e-02 3.755648e-02
## SM..OH..C22.2_T5 -3.646292e-03 1.614545e-02 2.483269e-02 2.874542e-02
## SM..OH..C24.1_T5 -1.647480e-03 -1.615893e-02 -5.033890e-03 1.526793e-03
## SM.C16.0_T5 9.260947e-03 3.082699e-02 -3.813692e-02 2.319293e-02
## SM.C16.1_T5 2.088881e-02 6.418725e-03 -4.246977e-03 2.389299e-02
## SM.C18.0_T5 2.338297e-03 1.698358e-02 -1.131566e-01 -1.020511e-03
## SM.C18.1_T5 1.268094e-02 2.386554e-05 -5.257770e-02 -6.577657e-03
## SM.C20.2_T5 2.555965e-04 -1.638825e-02 -8.379642e-03 -2.673729e-03
## SM.C24.0_T5 -2.272492e-02 4.159004e-02 -7.619512e-04 3.837586e-02
## SM.C24.1_T5 3.476208e-03 3.909833e-02 -7.438568e-02 1.825088e-02
## PC9 PC10 PC11 PC12
## GLU_T0 2.438452e-02 1.566445e-01 -4.372887e-02 0.0011411416
## INS_T0 1.184253e-02 8.319994e-02 2.652871e-03 -0.0733849937
## HOMA_T0 3.823989e-03 8.110610e-02 -9.874944e-03 -0.0358306318
## HBA1C_T0 -1.177425e-02 1.898548e-03 1.669542e-02 -0.0205642309
## HBA1C.mmol.mol_T0 -1.407810e-02 6.920943e-03 3.176609e-02 -0.0459906567
## PESO_T0 3.890771e-02 6.941303e-02 -2.343311e-02 -0.0275387049
## bmi_T0 3.080049e-02 -9.919143e-03 -4.904091e-02 -0.0080915758
## CC_T0 2.226370e-03 1.272202e-02 6.092447e-03 -0.0015101419
## CINT_T0 4.588102e-02 7.945161e-02 1.348185e-02 -0.0298353579
## CAD_T0 3.684231e-02 4.255537e-03 8.382336e-03 -0.0379595877
## TAD_T0 -2.067237e-02 -2.303461e-02 2.661606e-02 0.0410332013
## TAS_T0 -3.590976e-02 -8.087202e-04 -2.106133e-02 0.0555980575
## TG_T0 -3.087772e-02 4.398666e-03 5.465659e-02 -0.0269775481
## COL_T0 4.909724e-02 1.136076e-01 -5.689940e-02 -0.0587275521
## LDL_T0 7.350369e-02 9.894287e-02 -6.425331e-02 -0.0261281662
## HDL_T0 -2.763510e-02 6.424031e-02 -1.577859e-03 -0.0382009746
## VLDL_T0 -3.142117e-02 4.394110e-03 5.604014e-02 -0.0268912269
## PCR_T0 -5.438458e-02 -1.818322e-02 -1.701929e-02 0.0066885346
## LEP_T0 3.243940e-02 8.085803e-03 -1.464749e-02 0.0451618844
## ADIPO_T0 2.705243e-02 9.432527e-02 4.728377e-02 -0.0598368878
## GOT_T0 4.412787e-02 1.216938e-01 9.602560e-03 0.1195336419
## GPT_T0 2.567755e-02 1.458978e-01 -6.485978e-02 0.0588308400
## GGT_T0 8.337893e-03 9.089830e-02 -5.241746e-02 -0.0369032701
## URICO_T0 2.206514e-02 5.224728e-02 8.756666e-03 -0.0183215461
## CREAT_T0 1.669129e-04 1.252453e-02 1.380460e-03 -0.0017000046
## UREA_T0 1.003705e-01 1.401143e-01 1.664338e-02 0.0387527116
## HIERRO_T0 1.580885e-02 9.101780e-02 -6.653866e-02 -0.0965712555
## TRANSF_T0 3.419223e-02 -2.891149e-02 -5.468015e-03 0.0077835440
## FERR_T0 -3.973643e-02 1.150497e-01 2.706092e-02 0.0529335138
## Ile_T0 9.714631e-03 3.195125e-02 3.548193e-02 -0.0784626187
## Leu_T0 1.715408e-02 3.827818e-02 6.259876e-02 -0.0614262919
## Val_T0 3.354803e-02 2.610879e-02 5.710035e-02 -0.0330814993
## Ala_T0 4.255389e-02 -4.268654e-02 1.958970e-02 -0.0162419783
## Pro_T0 7.449581e-03 -5.826336e-02 -5.016666e-02 -0.0728170160
## Gly_T0 2.899142e-02 -7.114528e-02 -8.053249e-02 0.0824415977
## Ser_T0 9.080881e-02 -5.795801e-02 2.589640e-02 0.0177973175
## Trp_T0 3.092291e-03 -3.051119e-02 -1.147493e-02 -0.0593995380
## Phe_T0 5.006890e-02 -4.229088e-02 6.253676e-02 -0.0759304170
## Met_T0 -1.787007e-02 -3.264462e-02 -1.073945e-02 -0.0124652071
## Orn_T0 5.396143e-02 -9.152832e-02 -4.525014e-02 0.0342398428
## Arg_T0 3.893213e-03 -3.853434e-02 8.349294e-03 -0.0542870877
## His_T0 3.311645e-02 -3.783414e-02 2.667074e-03 -0.0074564206
## Asn_T0 -6.447793e-04 -7.022776e-02 4.598260e-02 -0.0387297410
## Asp_T0 5.205696e-02 -9.000165e-03 7.080223e-02 -0.0027085193
## Glu_T0 6.328748e-03 3.259883e-02 -3.338263e-03 -0.0180519533
## Gln_T0 1.752337e-02 -4.199215e-02 -7.537963e-02 0.0236704461
## Cit_T0 2.048357e-02 -3.828404e-02 -6.401562e-02 0.0119408129
## Tyr_T0 4.656140e-02 -5.165183e-03 -4.602666e-02 -0.0290117151
## Thr_T0 -4.020490e-03 -1.891177e-01 8.955926e-02 -0.0349854585
## Lys_T0 5.415181e-02 -5.341548e-02 -4.635663e-03 -0.0229300537
## Creatinine_T0 4.199168e-04 6.992753e-02 -3.718438e-02 0.0106878588
## Kynurenine_T0 7.045162e-03 -1.758450e-02 -1.133900e-02 0.0185493986
## Putrescine_T0 -4.498463e-02 -4.222731e-02 -5.938579e-02 -0.0791321129
## Sarcosine_T0 8.238727e-02 1.190373e-03 -8.262403e-03 -0.0363316116
## Serotonin_T0 2.137453e-03 5.210545e-02 3.048434e-02 -0.0700331395
## Taurine_T0 1.168160e-01 -8.913214e-03 6.970391e-02 0.0786319497
## SDMA_T0 3.129001e-03 2.935570e-03 -2.498528e-03 0.0010150726
## C0_T0 2.522264e-02 1.451991e-02 -7.608140e-02 0.0040093251
## C2_T0 -7.703068e-03 4.628583e-02 -4.883553e-02 0.0698138643
## C3.OH_T0 -8.229066e-04 -4.331127e-04 4.626461e-03 -0.0001621719
## C6..C4.1.DC._T0 6.613895e-02 -8.018376e-03 7.753703e-02 0.0285756020
## C5.DC..C6.OH._T0 -1.936501e-02 -3.520575e-02 -4.000415e-02 0.0104659989
## C7.DC_T0 -5.297089e-02 -2.337867e-03 6.483862e-03 -0.0431429736
## C8_T0 -4.018189e-03 1.315918e-03 3.441526e-03 0.0016369018
## C10_T0 -1.189032e-03 -9.512684e-04 2.073752e-03 -0.0012961270
## C10.1_T0 -1.675055e-03 -4.256642e-04 4.915413e-03 0.0001980352
## C10.2_T0 4.375004e-04 -2.949667e-04 5.114624e-03 0.0015851432
## C14.1_T0 -1.302469e-03 1.079755e-03 3.161211e-03 0.0020159229
## C14.2_T0 -8.302591e-04 2.098108e-04 4.375547e-03 0.0004363813
## C16.1_T0 -9.019826e-04 3.333817e-04 4.200210e-03 0.0013036524
## C16.2_T0 -1.488416e-03 1.346483e-04 5.072529e-03 0.0011937387
## C16.2.OH_T0 -1.597754e-03 5.810142e-05 4.577058e-03 0.0011110285
## C18.1_T0 2.370344e-04 4.841495e-04 2.668645e-03 0.0033654899
## C18.1.OH_T0 -1.265610e-03 -2.457760e-04 5.206536e-03 0.0013025119
## C18.2_T0 -4.375405e-04 4.393503e-04 4.163872e-03 0.0007574662
## lysoPC.a.C16.0_T0 2.952183e-02 -9.151482e-03 1.950465e-03 0.0018750756
## lysoPC.a.C16.1_T0 9.804633e-03 -1.591580e-02 -1.064637e-02 0.0134362415
## lysoPC.a.C17.0_T0 3.074221e-02 1.165314e-02 7.607259e-03 0.0122885026
## lysoPC.a.C18.0_T0 5.276709e-02 5.532772e-03 -1.292071e-02 0.0034371271
## lysoPC.a.C18.1_T0 5.647095e-02 6.249979e-03 -4.035763e-02 0.0299229016
## lysoPC.a.C18.2_T0 5.771512e-02 -1.249026e-02 -1.159836e-02 -0.0478989673
## lysoPC.a.C20.3_T0 2.024000e-02 -2.110278e-02 1.341915e-02 -0.0138092960
## lysoPC.a.C20.4_T0 5.429436e-02 -9.571835e-03 -5.333094e-02 0.0305718464
## lysoPC.a.C24.0_T0 1.683707e-03 3.982614e-03 2.888444e-03 0.0030942051
## lysoPC.a.C26.0_T0 1.142585e-02 -2.043052e-02 -2.291047e-02 0.0092098645
## lysoPC.a.C26.1_T0 -8.536606e-04 2.172839e-04 2.711270e-03 0.0022013004
## lysoPC.a.C28.0_T0 5.415131e-02 -5.602505e-02 5.623046e-03 -0.0049046401
## lysoPC.a.C28.1_T0 4.221111e-03 5.483069e-03 3.155003e-03 0.0051117391
## PC.aa.C24.0_T0 -2.370547e-02 -7.568416e-02 -4.140068e-02 0.1001484003
## PC.aa.C28.1_T0 1.433741e-02 -1.574586e-02 -3.609275e-03 -0.0020953317
## PC.aa.C30.0_T0 -5.517825e-03 5.867289e-04 2.102904e-02 -0.0111722717
## PC.aa.C32.0_T0 -7.125569e-02 1.235553e-02 -9.650078e-03 0.0192225755
## PC.aa.C32.1_T0 -7.477015e-02 -3.052369e-02 5.952072e-02 -0.0094079819
## PC.aa.C32.3_T0 -2.544614e-03 -1.197704e-03 6.434538e-03 0.0032198141
## PC.aa.C34.1_T0 -6.521834e-02 1.032839e-02 -1.764965e-02 0.0264169199
## PC.aa.C34.2_T0 -9.417528e-02 -9.981003e-03 1.192865e-01 -0.0588832164
## PC.aa.C34.3_T0 -2.675132e-02 -2.877577e-02 5.858419e-02 -0.0309529646
## PC.aa.C34.4_T0 -1.842264e-04 -5.941290e-03 1.748494e-02 0.0005875088
## PC.aa.C36.0_T0 4.355774e-03 1.614224e-02 2.485147e-02 0.0028001971
## PC.aa.C36.1_T0 1.822949e-02 -1.081130e-02 -2.947106e-02 0.0323889882
## PC.aa.C36.2_T0 -9.126208e-03 -6.798199e-03 2.489167e-02 -0.0371985333
## PC.aa.C36.3_T0 -4.365393e-02 -3.021804e-02 9.277189e-02 -0.0503029036
## PC.aa.C36.4_T0 -4.239864e-02 -1.748278e-02 2.365256e-03 0.0401675619
## PC.aa.C36.5_T0 -2.114021e-02 6.598235e-02 7.518126e-02 0.1085964277
## PC.aa.C38.0_T0 1.355538e-02 1.537954e-02 2.712888e-02 0.0327262647
## PC.aa.C38.1_T0 4.764418e-02 2.274842e-03 2.995523e-02 0.0644095041
## PC.aa.C38.3_T0 -1.727412e-03 -1.510051e-02 1.070440e-02 -0.0231376372
## PC.aa.C38.4_T0 1.734799e-02 -1.567909e-02 -6.460058e-02 0.0480786275
## PC.aa.C38.5_T0 -7.951134e-03 8.587592e-03 -3.954710e-02 0.0814483467
## PC.aa.C38.6_T0 -3.630422e-02 5.637563e-02 9.206512e-02 0.0920466975
## PC.aa.C40.1_T0 1.136515e-02 -6.965453e-02 4.466369e-02 0.0255149472
## PC.aa.C40.2_T0 7.325809e-04 8.216582e-03 1.826894e-03 0.0005781338
## PC.aa.C40.3_T0 9.536780e-04 1.045175e-02 1.729133e-03 0.0020497739
## PC.aa.C40.4_T0 1.618590e-03 1.931190e-03 -1.298123e-02 -0.0011867244
## PC.aa.C40.5_T0 8.379472e-03 -3.490584e-03 -2.318493e-02 0.0089595565
## PC.aa.C40.6_T0 3.624991e-04 7.298149e-02 5.257308e-02 0.1255662350
## PC.aa.C42.0_T0 1.267314e-03 7.067169e-03 3.931522e-03 0.0079873705
## PC.aa.C42.1_T0 2.842658e-04 4.958987e-03 4.880249e-03 0.0040170308
## PC.aa.C42.2_T0 2.255935e-03 7.844077e-03 6.074108e-03 0.0027357295
## PC.aa.C42.4_T0 -1.472881e-03 2.275456e-03 4.388978e-03 0.0032091634
## PC.aa.C42.5_T0 -1.274033e-03 3.942851e-03 5.976009e-03 0.0041176892
## PC.aa.C42.6_T0 -2.334212e-02 -7.500383e-03 -1.209203e-02 0.0141781417
## PC.ae.C30.0_T0 -4.943242e-04 1.490677e-03 5.369465e-03 0.0013963966
## PC.ae.C32.1_T0 -1.636935e-02 3.128040e-03 -7.280748e-03 -0.0129938734
## PC.ae.C32.2_T0 -3.009282e-03 2.700478e-03 2.619852e-03 0.0041373636
## PC.ae.C34.0_T0 1.782242e-03 4.001094e-03 7.452979e-03 0.0045768555
## PC.ae.C34.1_T0 3.504717e-03 4.608150e-03 -1.192594e-02 0.0160042828
## PC.ae.C34.2_T0 7.022528e-03 -9.633279e-03 3.374992e-02 -0.0542376956
## PC.ae.C34.3_T0 1.759964e-03 8.646178e-03 1.453944e-02 -0.0390958436
## PC.ae.C36.0_T0 2.511810e-03 1.004379e-02 2.534522e-03 0.0073115957
## PC.ae.C36.1_T0 1.460929e-02 2.380984e-02 -1.675301e-03 0.0014039384
## PC.ae.C36.2_T0 2.622372e-02 3.295569e-02 3.914351e-02 0.0032068335
## PC.ae.C36.3_T0 7.390643e-03 -1.776337e-02 1.389654e-02 -0.0272429216
## PC.ae.C36.4_T0 1.433152e-03 -3.786745e-02 -2.220332e-02 -0.0408082383
## PC.ae.C36.5_T0 -1.430431e-02 -5.625388e-03 -1.031319e-02 -0.0051490795
## PC.ae.C38.0_T0 -6.650855e-04 8.698859e-03 2.565479e-02 0.0192403984
## PC.ae.C38.2_T0 3.529208e-03 1.178361e-02 6.063624e-03 0.0067734282
## PC.ae.C38.3_T0 -5.857545e-03 1.328929e-02 -1.316389e-02 -0.0103970992
## PC.ae.C38.4_T0 2.632344e-02 -2.344048e-02 -2.749089e-02 -0.0042413289
## PC.ae.C38.5_T0 9.085294e-03 -3.257597e-02 -7.211317e-02 0.0079272112
## PC.ae.C38.6_T0 3.029811e-03 -8.265778e-03 1.892851e-02 0.0171124478
## PC.ae.C40.1_T0 4.990820e-03 1.413786e-02 1.158104e-02 0.0069045360
## PC.ae.C40.2_T0 5.060404e-03 1.187921e-02 1.975034e-03 0.0120109428
## PC.ae.C40.3_T0 -1.158306e-02 8.218780e-03 -1.497619e-02 -0.0059401797
## PC.ae.C40.4_T0 -8.715934e-04 1.237714e-03 -1.353653e-02 0.0016546849
## PC.ae.C40.5_T0 -1.559573e-03 4.185351e-03 -1.851578e-02 0.0070963923
## PC.ae.C40.6_T0 6.496662e-03 1.251684e-02 1.253491e-02 0.0268623443
## PC.ae.C42.1_T0 1.420075e-03 8.505136e-03 3.505950e-03 0.0015166277
## PC.ae.C42.2_T0 5.969172e-03 8.676059e-03 5.429485e-03 0.0025691465
## PC.ae.C42.3_T0 5.230356e-03 1.031070e-02 7.538531e-03 0.0071826508
## PC.ae.C42.4_T0 -5.092435e-04 4.642052e-04 2.317941e-03 -0.0004316179
## PC.ae.C42.5_T0 -1.835085e-03 6.738746e-03 -1.932829e-02 0.0109449010
## PC.ae.C44.3_T0 -6.174146e-04 2.184672e-03 5.447010e-03 0.0030380544
## PC.ae.C44.4_T0 -2.536603e-04 1.947117e-03 7.210890e-03 0.0022865689
## PC.ae.C44.5_T0 1.028352e-02 6.216483e-03 -1.347160e-02 0.0108280937
## PC.ae.C44.6_T0 2.009489e-03 4.229734e-03 6.993864e-04 0.0074084055
## SM..OH..C14.1_T0 3.217281e-02 1.866019e-02 8.742795e-04 0.0253016283
## SM..OH..C16.1_T0 1.427308e-02 1.092237e-02 -2.176544e-03 0.0146051251
## SM..OH..C22.1_T0 4.601709e-02 1.686346e-03 3.999732e-02 -0.0024603102
## SM..OH..C22.2_T0 4.591399e-02 2.460958e-02 4.396110e-03 0.0255602683
## SM..OH..C24.1_T0 5.169412e-03 3.576971e-03 4.772324e-03 0.0020432097
## SM.C16.0_T0 3.023888e-02 2.527331e-03 -7.891104e-02 0.0098137398
## SM.C16.1_T0 3.089070e-02 -1.398498e-02 -4.848559e-02 0.0417026555
## SM.C18.0_T0 -1.202560e-02 3.421147e-02 -6.737069e-02 0.0269109807
## SM.C18.1_T0 9.935133e-03 5.650201e-03 -5.749871e-02 0.0423722595
## SM.C20.2_T0 -2.204906e-03 2.889194e-04 5.498236e-03 0.0026832657
## SM.C24.0_T0 2.590007e-02 1.812651e-02 1.379958e-02 -0.0549488414
## SM.C24.1_T0 3.172821e-02 6.053888e-02 -6.070472e-02 0.0211836450
## MEDDM_T2 -1.749600e-03 -2.207597e-04 5.514135e-03 0.0016886642
## MEDCOL_T2 -1.749600e-03 -2.207597e-04 5.514135e-03 0.0016886642
## MEDINF_T2 1.073802e-02 -2.169181e-03 5.499598e-03 0.0096684667
## MEDHTA_T2 2.744333e-03 -2.493038e-03 3.551650e-03 0.0105892151
## GLU_T2 -8.040464e-02 -1.534454e-03 -3.645192e-02 -0.0826727365
## INS_T2 -1.455470e-03 1.058576e-01 2.636846e-02 0.0166082812
## HOMA_T2 -1.721233e-02 5.896013e-02 9.024573e-03 -0.0029057547
## HBA1C_T2 -1.866469e-02 1.934431e-03 9.089025e-03 -0.0147388426
## HBA1C.mmol.mol_T2 -4.687372e-02 9.282276e-03 1.385515e-02 -0.0395754867
## PESO_T2 -3.996100e-02 4.792402e-03 -5.610296e-02 -0.0046861161
## bmi_T2 -5.439833e-02 -8.760790e-02 -9.176157e-02 0.0125181754
## CC_T2 -3.330115e-03 3.180395e-03 7.853189e-03 0.0010885893
## CINT_T2 -3.267537e-02 -2.547401e-02 -3.721482e-03 0.0071539976
## CAD_T2 -4.376061e-02 -7.694771e-02 -3.730201e-02 -0.0014229483
## TAD_T2 -3.674138e-02 2.408975e-02 3.165393e-02 0.0021022451
## TAS_T2 -5.144915e-02 1.032674e-02 4.199758e-02 0.0282620518
## TG_T2 -5.238165e-02 -5.699211e-02 7.491251e-02 -0.0437275392
## COL_T2 3.732244e-03 4.966492e-03 -3.789377e-02 -0.0946462474
## LDL_T2 1.868101e-02 1.230630e-02 -8.715048e-02 -0.0976904420
## HDL_T2 -6.677259e-02 2.488449e-02 5.257104e-03 -0.0273675031
## VLDL_T2 -5.209887e-02 -1.132747e-01 1.754740e-01 0.0015005900
## PCR_T2 -1.830017e-02 -3.935942e-03 2.791217e-02 -0.0086044179
## LEP_T2 3.168884e-02 -6.125718e-02 -5.771016e-02 0.1438405149
## ADIPO_T2 1.571897e-02 8.014546e-02 4.411104e-02 -0.0062582151
## GOT_T2 2.228021e-02 4.052539e-02 -7.888622e-03 0.0882646606
## GPT_T2 8.101769e-03 3.634105e-02 2.623692e-02 0.0274718446
## GGT_T2 -4.851850e-02 5.059467e-02 -7.101961e-02 -0.1222737983
## URICO_T2 4.227973e-02 -5.331745e-02 8.082714e-02 0.0082861230
## CREAT_T2 -4.360571e-03 2.414756e-03 -2.007411e-03 0.0012131230
## UREA_T2 3.772326e-02 7.648248e-02 1.399225e-03 0.0026558020
## HIERRO_T2 6.913364e-02 6.104554e-02 -1.399134e-02 -0.0139462552
## TRANSF_T2 3.210866e-03 1.271075e-02 3.315105e-03 -0.0221571207
## FERR_T2 1.640012e-02 8.245482e-02 6.465144e-02 0.0230298027
## Ile_T2 5.052063e-02 -3.179452e-02 8.082869e-02 -0.0612761661
## Leu_T2 7.510430e-02 -7.317111e-03 1.184252e-01 -0.0390664414
## Val_T2 6.062708e-02 2.970554e-02 8.673447e-02 -0.0273913175
## Ala_T2 -4.965361e-02 -2.150844e-02 -8.922136e-02 0.0809352864
## Pro_T2 -3.229892e-02 -4.038788e-02 -3.638602e-02 -0.0241970817
## Gly_T2 -1.098524e-02 -1.134044e-01 -6.184091e-02 0.0755340322
## Ser_T2 1.802550e-02 -7.278438e-02 -3.313766e-02 0.0018552613
## Trp_T2 -3.226769e-02 6.286561e-02 2.801016e-02 -0.0349236430
## Phe_T2 3.813385e-02 -2.650647e-02 2.434629e-02 -0.0220316415
## Met_T2 -3.780731e-02 1.155330e-02 -6.735303e-02 0.1020735886
## Orn_T2 -8.681249e-03 -5.927436e-03 3.052949e-02 -0.0575022395
## Arg_T2 -1.016715e-02 5.989284e-03 -4.137115e-02 -0.0197440405
## His_T2 1.943650e-02 1.098003e-03 5.240918e-02 -0.0054791098
## Asn_T2 -5.908132e-02 -1.065075e-02 4.395179e-03 0.0033795614
## Asp_T2 9.302471e-02 -4.634613e-02 8.179066e-02 0.0508354728
## Glu_T2 -7.865619e-03 -2.968862e-02 -2.048585e-02 -0.0534555661
## Gln_T2 -7.726617e-02 -6.747845e-02 -3.214801e-02 0.0505391910
## Cit_T2 -5.613445e-02 7.249721e-03 -5.316835e-02 0.0022949046
## Tyr_T2 -6.655879e-04 3.641485e-02 -4.457884e-02 0.0194684259
## Thr_T2 6.619701e-03 -6.844192e-02 -6.759000e-02 -0.0412902764
## Lys_T2 2.555269e-02 1.658001e-02 -2.124907e-03 -0.0300684878
## Creatinine_T2 -1.900106e-03 -3.145752e-02 -9.801935e-02 0.0484549215
## Kynurenine_T2 -2.485123e-03 2.593708e-02 -2.030821e-02 0.0129233877
## Putrescine_T2 6.652030e-02 -6.024775e-02 2.980903e-02 0.0781277213
## Sarcosine_T2 -3.042963e-02 -6.332374e-02 -5.049497e-02 -0.0244823342
## Serotonin_T2 -7.673519e-02 -3.001253e-02 -1.614245e-02 -0.1243642193
## Taurine_T2 7.108312e-02 5.139463e-02 1.233043e-01 0.0763686610
## SDMA_T2 4.421092e-03 -6.543397e-03 -4.931097e-03 0.0126166768
## C0_T2 -6.316472e-02 -1.204439e-04 -8.497564e-02 0.0059315116
## C2_T2 1.189102e-01 -6.412399e-02 -7.030720e-02 0.1126108396
## C3.OH_T2 -2.290726e-03 6.545155e-04 2.744649e-03 -0.0022078970
## C6..C4.1.DC._T2 2.258994e-02 -7.766120e-02 1.090785e-02 -0.0254367965
## C5.DC..C6.OH._T2 -1.619005e-02 5.155818e-03 -1.095532e-01 -0.0155756251
## C7.DC_T2 2.990464e-02 -1.466274e-02 1.138201e-02 -0.0023680199
## C8_T2 -3.946277e-03 -2.016438e-03 -4.892815e-03 -0.0044819213
## C10_T2 -1.689649e-03 -2.955533e-03 -6.081421e-03 -0.0007395848
## C10.1_T2 -2.513332e-03 -2.849664e-03 1.533687e-03 0.0020764589
## C10.2_T2 -2.458157e-03 5.095748e-04 3.015318e-03 -0.0003455321
## C14.1_T2 9.581341e-04 -1.831067e-04 2.607623e-03 0.0011376951
## C14.2_T2 -6.780064e-04 -3.354923e-04 3.439437e-03 -0.0002416523
## C16.1_T2 -1.197514e-03 -2.329373e-04 3.646585e-03 0.0011283228
## C16.2_T2 -1.620023e-03 -2.986397e-04 4.920638e-03 0.0005425549
## C16.2.OH_T2 -1.925349e-03 -1.971836e-04 4.958466e-03 0.0007408784
## C18.1_T2 1.320525e-03 -2.112072e-03 3.154135e-03 0.0043350990
## C18.1.OH_T2 -1.464172e-03 -4.929566e-04 4.604429e-03 0.0007351050
## C18.2_T2 -1.373893e-03 -2.224329e-03 3.251917e-03 0.0007809380
## lysoPC.a.C14.0_T2 -3.677995e-02 -2.923850e-02 8.876420e-02 0.0581908527
## lysoPC.a.C16.0_T2 -1.208685e-02 -8.192508e-02 8.029034e-02 -0.0241047995
## lysoPC.a.C16.1_T2 -3.948579e-02 -1.446009e-02 8.883838e-03 0.0025430176
## lysoPC.a.C17.0_T2 -3.598833e-03 3.700620e-03 3.558876e-02 -0.0076883248
## lysoPC.a.C18.0_T2 -5.269251e-02 -2.915075e-02 6.362648e-02 -0.0239291566
## lysoPC.a.C18.1_T2 -2.505871e-02 -1.663872e-02 8.150667e-02 -0.0106986872
## lysoPC.a.C18.2_T2 -4.657792e-02 -2.341282e-02 9.445091e-02 -0.0658712176
## lysoPC.a.C20.3_T2 -3.207203e-02 2.221072e-02 3.415974e-02 -0.0229755470
## lysoPC.a.C20.4_T2 1.444971e-02 -1.112530e-01 9.779859e-02 -0.0213018757
## lysoPC.a.C24.0_T2 -2.777105e-03 8.500908e-05 5.345103e-03 -0.0080323068
## lysoPC.a.C26.0_T2 -9.179566e-03 -1.052720e-02 3.340391e-03 -0.1091144974
## lysoPC.a.C26.1_T2 -1.041887e-03 -3.110108e-03 5.151420e-03 -0.0075153838
## lysoPC.a.C28.0_T2 -2.385781e-02 -3.988558e-02 5.401882e-03 -0.0379939865
## lysoPC.a.C28.1_T2 -3.709839e-04 -1.106363e-03 8.998397e-03 -0.0085302107
## PC.aa.C24.0_T2 -1.298118e-01 -5.620048e-02 -8.064836e-02 -0.0829207712
## PC.aa.C28.1_T2 2.930604e-03 6.755254e-03 -9.384665e-04 -0.0124008972
## PC.aa.C30.0_T2 2.208935e-03 9.623885e-04 -1.712576e-02 -0.0126165401
## PC.aa.C32.0_T2 1.432949e-02 -4.641975e-02 -7.541881e-02 0.0057901909
## PC.aa.C32.1_T2 -8.722052e-02 9.063347e-03 -5.166026e-02 0.0119539189
## PC.aa.C32.3_T2 -6.695932e-04 -1.191564e-03 3.837161e-03 0.0023916435
## PC.aa.C34.1_T2 -7.697083e-03 -1.766733e-03 -5.023240e-02 0.0367099852
## PC.aa.C34.2_T2 -2.965096e-02 1.111724e-02 -3.471691e-02 -0.0108464339
## PC.aa.C34.3_T2 -8.067233e-02 4.185582e-02 -1.766267e-02 -0.0134416475
## PC.aa.C34.4_T2 -6.765616e-03 1.787664e-03 6.783151e-03 -0.0007239137
## PC.aa.C36.0_T2 -6.341451e-03 -5.793066e-03 2.698436e-02 -0.0150658643
## PC.aa.C36.1_T2 -3.845061e-02 4.876843e-02 -1.576159e-02 -0.0237283902
## PC.aa.C36.2_T2 -6.480395e-02 4.552595e-02 -4.789780e-02 -0.0137201942
## PC.aa.C36.3_T2 -6.441610e-02 8.761223e-02 -5.126831e-02 -0.0255967184
## PC.aa.C36.4_T2 5.568241e-02 -1.041115e-01 -3.371356e-03 0.0205163678
## PC.aa.C36.5_T2 -3.314449e-02 -3.607944e-03 1.515417e-01 0.0162920791
## PC.aa.C38.0_T2 8.104002e-04 2.896619e-03 1.602915e-02 0.0013676368
## PC.aa.C38.1_T2 5.861455e-02 -2.871147e-03 -3.771339e-02 -0.0221693999
## PC.aa.C38.3_T2 -3.806647e-02 6.544571e-02 -3.214165e-02 -0.0224144753
## PC.aa.C38.4_T2 1.558178e-03 -5.662668e-02 -6.919775e-03 0.0199731246
## PC.aa.C38.5_T2 -1.228018e-02 -1.200290e-02 1.706041e-02 0.0100805882
## PC.aa.C38.6_T2 2.917421e-03 -1.986587e-02 3.934234e-02 0.0816818640
## PC.aa.C40.1_T2 -6.924124e-02 -4.710837e-02 -7.295041e-03 -0.0143671371
## PC.aa.C40.2_T2 -4.678656e-03 -1.185868e-02 1.511581e-02 -0.0285623410
## PC.aa.C40.3_T2 1.189317e-03 -9.438854e-03 1.953338e-02 -0.0239311423
## PC.aa.C40.4_T2 -1.479429e-02 -8.520032e-03 -5.890299e-03 -0.0190113742
## PC.aa.C40.5_T2 -1.885592e-02 8.027006e-04 2.434047e-04 0.0021328353
## PC.aa.C40.6_T2 -3.058009e-02 -1.144868e-02 4.012578e-02 0.0608298334
## PC.aa.C42.0_T2 1.204363e-03 -2.812403e-03 6.591418e-03 -0.0034106153
## PC.aa.C42.1_T2 -8.630676e-04 -2.820587e-03 8.053977e-03 -0.0046885445
## PC.aa.C42.2_T2 -2.441937e-03 -6.136856e-03 1.532725e-02 -0.0088556520
## PC.aa.C42.4_T2 -5.244581e-03 -6.079982e-03 6.639555e-03 -0.0066574129
## PC.aa.C42.5_T2 -2.000450e-03 -2.636467e-03 9.132261e-03 -0.0037164715
## PC.aa.C42.6_T2 -2.984007e-02 -5.499950e-02 -4.436935e-02 -0.0534398559
## PC.ae.C30.0_T2 2.049246e-02 -2.869912e-02 -6.201548e-02 -0.0513567092
## PC.ae.C32.1_T2 -7.289163e-03 2.414964e-03 -3.817822e-03 -0.0092611737
## PC.ae.C32.2_T2 1.951732e-04 2.526118e-04 4.904568e-03 0.0004368340
## PC.ae.C34.0_T2 -2.687920e-04 2.624590e-03 6.139950e-03 0.0001831408
## PC.ae.C34.1_T2 1.971999e-03 3.323629e-02 -4.184153e-02 0.0136219169
## PC.ae.C34.2_T2 -5.188830e-03 4.079203e-02 7.715860e-04 -0.0161392083
## PC.ae.C34.3_T2 -9.197479e-03 2.884276e-02 1.884646e-02 -0.0177151862
## PC.ae.C36.0_T2 1.809620e-03 -2.074499e-04 6.262309e-03 -0.0059805546
## PC.ae.C36.1_T2 -1.689664e-03 -1.214117e-02 3.060512e-02 -0.0762661885
## PC.ae.C36.2_T2 -4.355065e-03 4.436821e-02 4.843645e-03 -0.0359354720
## PC.ae.C36.3_T2 -9.220431e-03 2.740392e-02 -3.608369e-03 -0.0036803256
## PC.ae.C36.4_T2 -1.033174e-02 1.068833e-03 -2.060577e-02 -0.0094113266
## PC.ae.C36.5_T2 -1.550596e-02 -9.174313e-03 2.554035e-02 -0.0050455480
## PC.ae.C38.0_T2 -1.471433e-02 1.123126e-03 1.836527e-02 0.0022830359
## PC.ae.C38.2_T2 -4.165890e-03 -9.514809e-03 2.407472e-02 -0.0597408459
## PC.ae.C38.3_T2 -9.173288e-03 -1.231086e-02 1.316578e-02 -0.0585365805
## PC.ae.C38.4_T2 3.414948e-03 -4.508882e-03 -1.125733e-02 -0.0078507268
## PC.ae.C38.5_T2 5.980881e-03 -9.338991e-03 -4.362373e-02 0.0179816901
## PC.ae.C38.6_T2 -9.233326e-03 4.946235e-03 2.626247e-03 0.0158618594
## PC.ae.C40.1_T2 -3.938301e-03 -1.171860e-02 2.784093e-02 -0.0273968282
## PC.ae.C40.2_T2 5.906797e-03 -1.431966e-03 1.157519e-02 -0.0151763794
## PC.ae.C40.3_T2 -8.555471e-03 -2.147302e-02 9.936931e-03 -0.0475325693
## PC.ae.C40.4_T2 -9.996471e-04 -1.631708e-02 9.088828e-03 -0.0306577721
## PC.ae.C40.5_T2 -6.578600e-03 -3.262640e-02 -1.387098e-02 -0.0102971379
## PC.ae.C40.6_T2 2.967512e-03 2.887625e-03 5.880075e-03 0.0113148288
## PC.ae.C42.1_T2 -2.775885e-03 -5.528474e-03 1.248924e-02 -0.0182332770
## PC.ae.C42.2_T2 1.180939e-03 -4.653578e-03 1.604582e-02 -0.0164618813
## PC.ae.C42.3_T2 -2.580995e-03 -8.777222e-03 1.598032e-02 -0.0167319200
## PC.ae.C42.4_T2 -2.236861e-03 -4.914132e-03 2.543882e-03 -0.0125497480
## PC.ae.C42.5_T2 2.604033e-03 -1.864488e-02 -1.719446e-02 -0.0029721488
## PC.ae.C44.3_T2 4.386574e-02 -1.097872e-02 3.348892e-02 0.0477667398
## PC.ae.C44.4_T2 -1.651125e-03 4.000952e-04 5.684539e-03 -0.0046074118
## PC.ae.C44.5_T2 1.207539e-02 -2.856619e-03 -1.189010e-02 0.0011050811
## PC.ae.C44.6_T2 4.470381e-03 -8.023470e-03 7.614233e-04 -0.0089197136
## SM..OH..C14.1_T2 3.407758e-02 1.827549e-02 -2.352631e-03 0.0049211529
## SM..OH..C16.1_T2 1.532831e-02 8.149757e-03 -5.247941e-03 0.0039515263
## SM..OH..C22.1_T2 8.762428e-03 2.387552e-02 6.283526e-03 -0.0273168232
## SM..OH..C22.2_T2 2.452668e-02 2.054029e-02 -3.807063e-03 -0.0154546613
## SM..OH..C24.1_T2 1.038283e-03 2.179560e-03 4.906484e-03 -0.0024402279
## SM.C16.0_T2 3.535308e-02 -1.372327e-02 -5.475868e-02 -0.0439789305
## SM.C16.1_T2 5.265534e-02 -3.926306e-02 -5.504333e-02 0.0218098268
## SM.C18.0_T2 4.089960e-02 -4.009198e-02 -8.600465e-02 -0.0128112110
## SM.C18.1_T2 3.536327e-02 -4.405124e-02 -6.496450e-02 0.0428750458
## SM.C20.2_T2 -1.331726e-03 -5.017183e-04 1.868595e-03 0.0006729776
## SM.C24.0_T2 2.164601e-04 -2.475467e-03 1.275686e-02 -0.0519350681
## SM.C24.1_T2 2.829636e-02 -2.668050e-03 -4.834760e-02 0.0027343204
## MEDDM_T4 -1.295473e-03 -5.331804e-03 5.530460e-03 0.0097149252
## MEDCOL_T4 -2.650089e-03 -5.983372e-04 3.549935e-03 0.0054578323
## MEDINF_T4 3.318262e-03 -1.372820e-03 2.427305e-03 0.0019825183
## MEDHTA_T4 -6.455330e-03 5.089846e-03 8.611329e-04 0.0108380690
## GLU_T4 -7.493697e-02 2.376852e-02 3.139682e-02 -0.0445207893
## INS_T4 -2.340086e-02 1.127757e-01 2.021811e-02 0.0578442030
## HOMA_T4 -2.509828e-02 4.256145e-02 1.368028e-02 0.0209313295
## HBA1C_T4 -2.010392e-02 -2.015043e-03 6.295856e-03 -0.0130612070
## HBA1C.mmol.mol_T4 -4.527543e-02 -5.261190e-03 2.236632e-03 -0.0284371325
## PESO_T4 -5.312961e-02 1.809541e-02 -5.026330e-02 -0.0063546167
## bmi_T4 -7.402317e-02 -7.316531e-02 -9.495582e-02 0.0136152531
## CC_T4 -7.056194e-04 5.256027e-03 9.987147e-03 0.0024911345
## CINT_T4 -2.697782e-02 -2.008694e-02 1.800854e-02 0.0026937986
## CAD_T4 -4.924032e-02 -7.074472e-02 -4.318821e-02 -0.0083538540
## TAD_T4 -4.321823e-02 -2.328115e-02 -6.655867e-03 0.0072105683
## TAS_T4 -2.975666e-02 -2.650662e-02 3.241129e-02 0.0122856330
## TG_T4 -1.174818e-01 -6.447793e-02 5.175604e-02 0.0115176366
## COL_T4 3.723046e-02 1.441646e-03 -2.590997e-02 -0.0426816828
## LDL_T4 5.956884e-02 1.164449e-02 -6.159743e-02 -0.0403188683
## HDL_T4 -3.760033e-02 2.357316e-03 -2.754176e-02 -0.0687380226
## VLDL_T4 -7.524685e-02 -1.205780e-01 1.377404e-01 0.0435821939
## PCR_T4 -6.069087e-02 -3.194738e-02 -3.272802e-02 0.0124664058
## LEP_T4 -1.018098e-02 -9.596398e-03 -8.770465e-02 0.1675452062
## ADIPO_T4 2.289002e-03 -5.989597e-03 2.140253e-02 0.0303903548
## GOT_T4 -4.115118e-02 -3.525690e-02 -4.441703e-02 0.0865174808
## GPT_T4 -8.637388e-02 2.736998e-02 -5.735997e-02 0.0716564597
## GGT_T4 -8.546196e-02 1.954159e-03 -2.662139e-02 -0.0027861727
## URICO_T4 1.068767e-02 -1.214144e-02 -5.310204e-03 0.0180252855
## CREAT_T4 -9.150039e-03 2.085617e-03 -1.853854e-03 0.0068742710
## UREA_T4 2.133015e-04 8.106883e-02 -3.805009e-02 -0.0104724145
## HIERRO_T4 -4.348133e-02 -3.944859e-02 8.162162e-02 0.1245721974
## TRANSF_T4 -3.453523e-02 -1.667368e-02 -7.195757e-03 0.0116768459
## FERR_T4 -7.816823e-03 9.822035e-02 4.360047e-02 0.0421972259
## Ile_T4 1.163504e-02 5.193232e-02 2.405492e-02 -0.0828697675
## Leu_T4 2.297811e-02 4.197335e-02 2.729327e-02 -0.0534384897
## Val_T4 9.445198e-03 6.522680e-02 2.092756e-02 -0.0380519760
## Ala_T4 -1.763418e-02 4.546700e-02 -2.391798e-02 0.0257009908
## Pro_T4 -2.278118e-02 2.859739e-02 -4.347456e-02 -0.0015923672
## Gly_T4 5.739095e-02 1.747084e-02 -3.888554e-02 0.0603150933
## Ser_T4 7.153170e-02 -5.511175e-02 7.909896e-02 0.0398153550
## Trp_T4 -2.676004e-02 8.555640e-02 -1.227187e-03 -0.0386540416
## Phe_T4 -2.049453e-02 8.016591e-03 2.689865e-02 0.0096587295
## Met_T4 4.800276e-02 4.112174e-02 5.443935e-02 0.0135018112
## Orn_T4 1.122618e-02 4.395973e-02 -7.633567e-03 -0.0011770820
## Arg_T4 -4.245186e-04 2.720594e-02 3.275895e-02 -0.0485316685
## His_T4 1.146091e-02 3.378728e-02 5.347014e-02 0.0032244036
## Asn_T4 4.670200e-03 5.058516e-02 2.127590e-02 -0.0173025573
## Asp_T4 2.658399e-02 -2.661118e-02 7.518619e-02 -0.0403337687
## Glu_T4 -6.579921e-02 -1.925407e-02 -2.812359e-02 -0.0231977186
## Gln_T4 -2.593357e-02 -9.741863e-02 8.213071e-02 -0.0168638094
## Cit_T4 -4.439789e-02 5.884181e-02 -7.484107e-02 0.0048290743
## Tyr_T4 -5.397288e-03 7.515435e-02 -4.532767e-02 0.0132189660
## Thr_T4 3.149534e-02 7.354850e-02 2.410017e-02 -0.0485327644
## Lys_T4 -2.347232e-02 1.263432e-02 1.645377e-02 -0.0697487960
## Creatinine_T4 -2.590991e-02 3.789686e-02 -7.452025e-02 -0.0064326814
## Kynurenine_T4 -7.620445e-02 -4.202042e-02 5.501209e-02 0.1265185922
## Putrescine_T4 4.423712e-02 1.334575e-01 -7.661190e-02 -0.0814278634
## Sarcosine_T4 -6.045354e-02 -2.451042e-02 -1.054396e-01 -0.0223365154
## Serotonin_T4 -8.411942e-02 -3.496282e-02 -2.381245e-02 -0.1033833319
## Taurine_T4 3.545426e-02 -4.708329e-02 2.572742e-02 -0.0312944405
## SDMA_T4 8.916119e-03 3.956933e-03 -2.056975e-03 0.0106525786
## C0_T4 -5.421013e-02 4.133338e-02 -5.315085e-02 0.0150384969
## C2_T4 1.113633e-01 -5.976079e-02 4.059245e-03 -0.0349456801
## C3.OH_T4 -9.781871e-04 -1.658117e-03 5.651928e-03 0.0024056703
## C6..C4.1.DC._T4 1.407094e-02 1.375677e-02 5.126134e-02 -0.1105328308
## C5.DC..C6.OH._T4 -3.389654e-02 -1.282606e-02 2.850482e-02 0.0848781270
## C7.DC_T4 2.193740e-02 -1.220653e-02 2.853109e-02 -0.0297964024
## C8_T4 -8.918929e-04 -3.387141e-03 4.262850e-03 0.0042676275
## C10_T4 1.240142e-03 -5.756215e-03 3.949145e-03 0.0083002701
## C10.1_T4 -1.166841e-03 -1.045918e-03 5.606479e-03 0.0037787876
## C10.2_T4 -1.830344e-03 -9.723453e-04 4.566798e-03 0.0013333581
## C14.1_T4 1.020480e-03 -1.907603e-03 4.578690e-03 0.0023696824
## C14.2_T4 -8.037149e-04 -7.107741e-04 5.414957e-03 0.0014237106
## C16.1_T4 3.751107e-02 -3.243110e-02 1.858516e-02 -0.0018264391
## C16.2_T4 -1.126651e-03 -7.809452e-04 5.077796e-03 0.0015449444
## C16.2.OH_T4 3.736621e-02 -3.208838e-02 1.918626e-02 -0.0020701484
## C18.1_T4 1.755487e-03 -3.035026e-04 3.763649e-03 0.0036094795
## C18.1.OH_T4 -1.576510e-03 -4.564687e-04 5.127279e-03 0.0013681041
## C18.2_T4 -9.847642e-04 -9.932597e-04 4.923804e-03 0.0019841141
## lysoPC.a.C16.0_T4 4.037983e-02 7.544760e-03 -3.310141e-02 0.0115412067
## lysoPC.a.C16.1_T4 -2.723577e-02 1.393745e-02 -5.499241e-02 0.0440453833
## lysoPC.a.C17.0_T4 -5.800321e-03 2.598344e-02 -1.117355e-02 0.0128179911
## lysoPC.a.C18.0_T4 1.112485e-02 2.918098e-02 -1.060694e-01 0.0176435860
## lysoPC.a.C18.1_T4 4.429074e-02 6.319496e-02 -8.939372e-02 0.0681703998
## lysoPC.a.C18.2_T4 1.578698e-02 9.278644e-02 -6.053442e-02 -0.0237613762
## lysoPC.a.C20.3_T4 -4.325612e-02 2.258825e-02 -1.070803e-02 0.0039024720
## lysoPC.a.C20.4_T4 9.082234e-02 -1.459664e-04 -6.507288e-02 0.0011632926
## lysoPC.a.C24.0_T4 -6.517620e-03 -1.212414e-03 3.279045e-04 0.0004975587
## lysoPC.a.C26.0_T4 -6.810683e-02 -5.640325e-02 1.065247e-02 0.0779078192
## lysoPC.a.C26.1_T4 -2.069844e-03 -3.928337e-03 -6.978009e-04 0.0035508310
## lysoPC.a.C28.0_T4 -7.398017e-02 1.194107e-03 -1.732627e-02 -0.0499178987
## lysoPC.a.C28.1_T4 -6.808825e-03 -5.394078e-04 -3.374665e-03 0.0018973755
## PC.aa.C24.0_T4 -7.051444e-02 2.596789e-02 -8.264745e-02 0.0638251598
## PC.aa.C28.1_T4 -1.082328e-03 6.940969e-03 -1.902713e-02 -0.0117843172
## PC.aa.C30.0_T4 -1.847169e-02 -1.317830e-03 -4.181354e-03 -0.0154490899
## PC.aa.C32.0_T4 1.668858e-02 1.666794e-02 2.792293e-03 -0.0032078459
## PC.aa.C32.1_T4 -1.399527e-01 -9.440877e-03 -2.535094e-02 0.0307321516
## PC.aa.C32.3_T4 -9.201313e-04 -1.182859e-03 4.904797e-03 0.0031834647
## PC.aa.C34.1_T4 -2.100532e-02 2.065384e-02 1.186823e-02 0.0358508612
## PC.aa.C34.2_T4 -4.637610e-02 2.027928e-02 9.766321e-02 -0.0411198330
## PC.aa.C34.3_T4 -1.257884e-01 3.302441e-02 7.458715e-03 0.0106919465
## PC.aa.C34.4_T4 -1.229109e-02 2.888821e-04 6.136133e-03 0.0022554930
## PC.aa.C36.0_T4 -1.524409e-02 2.413201e-03 3.147619e-03 0.0057142936
## PC.aa.C36.1_T4 -9.404976e-02 1.731575e-02 -7.178422e-02 0.0088955135
## PC.aa.C36.2_T4 -7.241037e-02 4.377590e-02 -4.812382e-02 -0.0145522606
## PC.aa.C36.3_T4 -1.239933e-01 2.884162e-02 4.338030e-02 -0.0050689253
## PC.aa.C36.4_T4 5.251400e-02 -3.912048e-02 4.341864e-02 -0.0300822379
## PC.aa.C36.5_T4 -4.321603e-02 6.057243e-02 4.913536e-02 0.0748988472
## PC.aa.C38.0_T4 6.521981e-03 1.275282e-02 -1.650410e-02 0.0186605785
## PC.aa.C38.1_T4 -1.748230e-02 1.304953e-03 -5.250107e-03 -0.0002006813
## PC.aa.C38.3_T4 -1.033076e-01 2.484938e-02 -2.837121e-02 0.0023824832
## PC.aa.C38.4_T4 4.534849e-02 -9.485006e-03 -6.920821e-02 -0.0129272609
## PC.aa.C38.5_T4 2.143364e-02 1.654691e-02 -3.914828e-02 0.0083500721
## PC.aa.C38.6_T4 1.702596e-03 3.532248e-02 7.096462e-02 0.0360990449
## PC.aa.C40.1_T4 -8.474161e-02 -1.229185e-02 2.478016e-03 0.0106947333
## PC.aa.C40.2_T4 -2.132563e-02 -1.145196e-02 -1.386711e-02 -0.0020841038
## PC.aa.C40.3_T4 -1.551076e-02 -8.432729e-03 -1.038642e-02 -0.0010668881
## PC.aa.C40.4_T4 -2.320279e-02 -2.394261e-02 -3.453169e-02 -0.0121040357
## PC.aa.C40.5_T4 2.307931e-03 -8.444595e-03 -4.986669e-02 -0.0167174637
## PC.aa.C40.6_T4 -2.475407e-02 4.127912e-02 -6.010511e-03 0.0487025383
## PC.aa.C42.0_T4 -3.870217e-03 4.360429e-03 -2.426919e-03 -0.0004417728
## PC.aa.C42.1_T4 -5.114811e-03 -1.085054e-04 3.747784e-04 0.0011432534
## PC.aa.C42.2_T4 -9.262751e-03 -2.642589e-03 -7.594724e-05 0.0022149311
## PC.aa.C42.4_T4 -1.052726e-02 -6.405428e-03 -8.049988e-04 0.0008754701
## PC.aa.C42.5_T4 -7.323015e-03 -2.400807e-03 2.884554e-03 0.0014305754
## PC.aa.C42.6_T4 -6.054114e-02 -4.924675e-02 -2.898328e-03 0.0683357786
## PC.ae.C30.0_T4 -2.203024e-02 -7.578749e-02 -1.912135e-02 -0.0185215624
## PC.ae.C32.1_T4 9.371062e-03 3.689998e-03 -1.189111e-02 -0.0045905359
## PC.ae.C32.2_T4 1.086619e-03 3.918959e-03 6.520971e-04 0.0055431117
## PC.ae.C34.0_T4 -2.640836e-03 2.582667e-03 2.715145e-03 0.0007981227
## PC.ae.C34.1_T4 4.116153e-03 2.238277e-02 -3.026539e-02 0.0113338502
## PC.ae.C34.2_T4 5.078699e-03 4.567501e-02 -1.321030e-03 -0.0303250354
## PC.ae.C34.3_T4 3.957786e-02 3.918072e-02 3.077758e-02 -0.0545512347
## PC.ae.C36.0_T4 -2.447907e-03 5.289520e-03 -2.311451e-03 -0.0011379638
## PC.ae.C36.1_T4 -5.829928e-02 -1.941394e-02 -2.693233e-02 0.0069053814
## PC.ae.C36.2_T4 -4.702053e-02 5.051322e-02 1.368048e-02 -0.0169190054
## PC.ae.C36.3_T4 1.334863e-04 1.531508e-02 -1.742777e-04 -0.0133291460
## PC.ae.C36.4_T4 4.367763e-02 -2.341534e-02 -2.525184e-02 -0.0183500304
## PC.ae.C36.5_T4 4.453169e-02 9.629096e-03 -7.336372e-03 -0.0141288387
## PC.ae.C38.0_T4 -1.777307e-02 1.548673e-02 1.038314e-02 0.0139101803
## PC.ae.C38.2_T4 -5.790050e-02 -1.554894e-02 -3.499079e-02 0.0017937244
## PC.ae.C38.3_T4 -6.477336e-02 -2.644613e-02 -4.097382e-02 -0.0073185533
## PC.ae.C38.4_T4 1.608328e-02 -1.126379e-02 -3.116375e-02 -0.0249284683
## PC.ae.C38.5_T4 6.674743e-02 -1.770418e-02 -6.574850e-02 -0.0043392121
## PC.ae.C38.6_T4 1.956796e-02 3.195460e-03 -6.375032e-03 0.0093377754
## PC.ae.C40.1_T4 -1.811397e-02 -2.586041e-03 -1.397305e-02 0.0012474342
## PC.ae.C40.2_T4 -1.500571e-02 -2.820296e-03 -1.666790e-02 0.0063025899
## PC.ae.C40.3_T4 -4.676762e-02 -2.052814e-02 -4.034991e-02 -0.0074752094
## PC.ae.C40.4_T4 -3.236552e-02 -1.495357e-02 -4.178233e-02 -0.0159697227
## PC.ae.C40.5_T4 -1.637092e-02 -3.271541e-02 -4.258599e-02 0.0049547833
## PC.ae.C40.6_T4 3.779801e-03 1.019306e-02 -3.216061e-03 -0.0019570226
## PC.ae.C42.1_T4 -1.599005e-02 -5.173152e-03 -6.604195e-03 0.0004231795
## PC.ae.C42.2_T4 -1.386100e-02 5.028259e-05 -7.429963e-03 -0.0013216977
## PC.ae.C42.3_T4 -1.589464e-02 -3.814850e-03 -5.022884e-03 0.0034947117
## PC.ae.C42.4_T4 -1.207602e-02 -1.894867e-03 -7.221414e-03 -0.0079837073
## PC.ae.C42.5_T4 6.300763e-03 -5.421748e-04 -3.765709e-02 -0.0010889071
## PC.ae.C44.3_T4 -6.826162e-03 -2.207277e-03 2.053766e-03 0.0024287768
## PC.ae.C44.4_T4 -5.741591e-03 1.191747e-03 1.924667e-03 -0.0021985656
## PC.ae.C44.5_T4 1.709520e-02 1.620136e-02 -1.897851e-02 -0.0137942015
## PC.ae.C44.6_T4 2.162904e-03 1.032298e-02 -7.603335e-03 -0.0166169021
## SM..OH..C14.1_T4 4.780053e-02 2.720107e-02 -2.271664e-04 0.0005496719
## SM..OH..C16.1_T4 2.352904e-02 1.407374e-02 4.451120e-03 0.0079479161
## SM..OH..C22.1_T4 -3.576727e-03 6.416017e-03 1.660380e-02 -0.0365897134
## SM..OH..C22.2_T4 2.778896e-02 1.927775e-02 5.258520e-03 -0.0102785912
## SM..OH..C24.1_T4 -5.972742e-04 2.067723e-03 6.147719e-03 -0.0035982009
## SM.C16.0_T4 9.719893e-02 -1.283219e-03 -2.714603e-02 -0.0380455309
## SM.C16.1_T4 1.117830e-01 -1.129718e-02 -1.636837e-02 0.0060722674
## SM.C18.0_T4 8.678898e-02 -4.460900e-03 1.913085e-02 -0.0158605584
## SM.C18.1_T4 1.050777e-01 9.065340e-04 7.384252e-03 0.0186197115
## SM.C20.2_T4 -2.077015e-05 -4.417493e-04 7.731068e-03 0.0014703816
## SM.C24.0_T4 -1.547723e-02 -1.798613e-02 -1.609691e-02 -0.0805591119
## SM.C24.1_T4 6.460294e-02 1.248107e-02 1.246190e-02 -0.0248924860
## MEDDM_T5 -2.081174e-02 1.056882e-02 -7.765598e-03 -0.0039299087
## MEDCOL_T5 -2.081174e-02 1.056882e-02 -7.765598e-03 -0.0039299087
## MEDINF_T5 -1.562626e-02 9.368336e-03 -1.014908e-02 -0.0058726748
## MEDHTA_T5 -2.029859e-02 5.276411e-03 -7.706921e-03 0.0043546784
## GLU_T5 -4.850176e-02 8.815011e-02 -3.588817e-02 -0.0608892550
## INS_T5 -2.914502e-02 6.020734e-02 -1.844044e-02 0.0632741786
## HOMA_T5 -2.224748e-02 2.130206e-02 -7.098189e-03 0.0292288118
## HBA1C_T5 -1.398728e-02 6.576271e-03 6.188167e-03 -0.0180955006
## HBA1C.mmol.mol_T5 -2.469779e-02 2.414254e-02 1.775917e-03 -0.0459650659
## PESO_T5 -1.549499e-02 8.774059e-02 -5.724180e-02 -0.0066225623
## bmi_T5 -2.948982e-02 3.666861e-02 -8.377885e-02 -0.0032648621
## CC_T5 -1.976964e-03 1.275530e-03 6.416352e-03 0.0013134145
## CINT_T5 2.636169e-02 6.735410e-02 -7.109619e-03 -0.0187550742
## CAD_T5 -1.879027e-03 3.834517e-02 -3.794307e-02 -0.0162866081
## TAD_T5 -4.854968e-02 -2.153560e-02 -1.952808e-02 -0.0542149538
## TAS_T5 -3.507771e-02 -6.366392e-03 -2.581057e-02 -0.0155192250
## TG_T5 -3.797592e-02 1.111037e-02 4.466578e-02 0.0348026225
## COL_T5 6.626638e-02 2.055128e-02 -2.699682e-02 0.0071322784
## LDL_T5 6.665046e-02 -8.472541e-03 -6.801093e-02 0.0428541658
## HDL_T5 1.488909e-02 6.985152e-02 2.085830e-02 -0.0910290601
## VLDL_T5 -2.392753e-02 7.682472e-03 3.734754e-02 0.0161033589
## PCR_T5 -5.071122e-02 -5.009994e-02 -3.546458e-02 0.0112419839
## LEP_T5 -4.134818e-02 -1.028549e-02 -3.014177e-02 0.1162121439
## ADIPO_T5 2.051206e-02 3.396495e-02 2.540838e-02 -0.0252458677
## GOT_T5 -3.068490e-02 1.275141e-02 5.060946e-02 0.1258844589
## GPT_T5 -4.343434e-02 1.247998e-01 1.539874e-02 -0.0002728195
## GGT_T5 -4.526442e-02 5.488615e-02 -5.448673e-02 -0.0398235266
## URICO_T5 8.480467e-03 2.192658e-02 -1.625237e-02 0.0171849560
## CREAT_T5 -3.509225e-03 3.737331e-03 2.195526e-03 -0.0009646659
## UREA_T5 3.323230e-02 1.235930e-01 3.873472e-02 -0.0486405975
## HIERRO_T5 9.666549e-02 9.877007e-03 2.441010e-02 0.0629378810
## TRANSF_T5 8.463357e-03 1.015686e-01 6.807358e-02 0.0110761344
## FERR_T5 6.369155e-03 5.604180e-02 7.838224e-03 0.0855653557
## Ile_T5 -3.336954e-02 4.904461e-02 1.376321e-03 0.0211100523
## Leu_T5 -1.226412e-02 6.550521e-02 2.355205e-03 0.0831055150
## Val_T5 8.561579e-03 5.148652e-02 3.524355e-04 0.0631247085
## Ala_T5 -4.279643e-02 -3.753889e-02 -1.515545e-02 0.0120853408
## Pro_T5 -1.548274e-02 -3.581537e-02 -6.748290e-02 -0.0470365194
## Gly_T5 5.110683e-02 5.064507e-03 -4.531085e-02 0.0800065704
## Ser_T5 9.573323e-02 -3.281263e-02 1.582205e-02 0.0332329245
## Trp_T5 -6.489964e-02 9.255702e-02 -1.766283e-03 0.0649768499
## Phe_T5 -6.020638e-02 2.843089e-02 7.487516e-03 0.1048608106
## Met_T5 -3.116552e-02 1.358938e-01 1.940083e-02 0.0116821619
## Orn_T5 -1.063276e-02 1.983470e-02 1.400235e-03 0.0742736238
## Arg_T5 -6.133284e-03 4.969942e-02 -2.487106e-02 -0.0142279137
## His_T5 -1.065237e-02 5.017631e-02 4.421831e-02 0.0380128807
## Asn_T5 4.016550e-02 3.968642e-02 2.486978e-02 0.0006018909
## Asp_T5 5.652827e-02 -4.405295e-02 6.944922e-02 0.1040657890
## Glu_T5 -7.596332e-02 -4.206812e-02 -6.550175e-02 -0.0072195118
## Gln_T5 4.561856e-02 4.329151e-02 8.141199e-03 0.0040326035
## Cit_T5 -3.769347e-02 8.063827e-03 -2.266801e-02 -0.0012472115
## Tyr_T5 -4.804466e-02 6.530464e-02 -4.718506e-02 0.0370228578
## Thr_T5 6.606665e-02 4.352222e-03 1.051103e-02 -0.0728558160
## Lys_T5 -6.104850e-03 6.392268e-02 2.823993e-03 0.0417210684
## Creatinine_T5 -6.518946e-02 2.181837e-02 -5.235192e-02 0.0198717582
## Kynurenine_T5 6.785544e-02 2.194862e-02 1.775936e-02 0.0499149696
## Putrescine_T5 2.719406e-02 -9.670620e-02 -1.667975e-02 0.1132713134
## Sarcosine_T5 -9.345545e-02 -6.952194e-02 -1.749498e-02 0.0734954566
## Serotonin_T5 -8.591257e-02 -4.374103e-02 -1.610258e-02 -0.1078159776
## Taurine_T5 1.077503e-01 -1.716561e-02 -8.698445e-02 0.0552367466
## SDMA_T5 -4.224464e-04 -3.736524e-03 1.276075e-03 0.0088220795
## C0_T5 -5.126281e-02 -4.727597e-03 -1.019627e-01 0.0227227533
## C2_T5 1.041443e-01 -1.868672e-02 -6.272151e-02 0.0470593600
## C3.OH_T5 -2.468334e-03 1.207828e-04 7.344300e-03 0.0017412401
## C6..C4.1.DC._T5 -3.011431e-04 2.924333e-02 4.014715e-02 -0.1492243831
## C5.DC..C6.OH._T5 -4.565800e-02 -2.436569e-02 -4.850992e-03 -0.0537736075
## C7.DC_T5 4.927564e-02 -2.413672e-02 1.949181e-02 0.0249028950
## C8_T5 -1.468589e-03 -5.079379e-03 3.260574e-03 0.0040353782
## C10_T5 1.209398e-04 -7.536917e-03 4.751249e-04 0.0061069470
## C10.1_T5 5.625801e-02 2.653400e-02 4.729538e-02 0.0460891279
## C10.2_T5 -1.405341e-03 -1.181242e-03 5.948637e-03 0.0017513635
## C14.1_T5 -4.788676e-04 -5.594180e-04 4.071114e-03 0.0033600112
## C14.2_T5 -1.842739e-03 -9.676381e-04 5.817099e-03 0.0027097426
## C16.1_T5 -2.063751e-03 -3.208800e-04 6.088143e-03 0.0023769162
## C16.2_T5 -1.884189e-03 -6.080136e-04 5.628540e-03 0.0018887851
## C16.2.OH_T5 -2.143942e-02 -2.639279e-02 4.992767e-02 0.0427751311
## C18.1_T5 -5.696302e-04 -6.520994e-04 3.513107e-03 0.0034940070
## C18.1.OH_T5 -1.977882e-03 -5.208588e-04 5.616562e-03 0.0017998338
## C18.2_T5 -1.811747e-03 -1.189840e-03 5.334482e-03 0.0019002457
## lysoPC.a.C16.0_T5 5.382241e-02 -4.164355e-02 -5.346017e-02 -0.0464451069
## lysoPC.a.C16.1_T5 -1.750179e-02 7.999928e-03 -2.727774e-02 0.0263609031
## lysoPC.a.C17.0_T5 1.705870e-02 8.507843e-03 -7.338015e-03 0.0024993974
## lysoPC.a.C18.0_T5 4.328994e-02 -4.144375e-02 -8.426773e-02 -0.0193554833
## lysoPC.a.C18.1_T5 8.918043e-02 -1.695322e-02 -8.285669e-02 -0.0502891957
## lysoPC.a.C18.2_T5 6.050813e-02 9.555206e-04 -4.958579e-02 -0.0900901983
## lysoPC.a.C20.3_T5 -1.558597e-02 1.822192e-03 -9.387871e-03 -0.0465404893
## lysoPC.a.C20.4_T5 7.430601e-02 -4.716172e-02 -4.170576e-02 -0.0896028541
## lysoPC.a.C24.0_T5 -2.045402e-03 4.862511e-04 8.528908e-03 0.0028554268
## lysoPC.a.C26.0_T5 -6.285003e-03 -2.453344e-03 8.517389e-03 0.0041849214
## lysoPC.a.C26.1_T5 -2.513678e-03 -7.387196e-04 9.935515e-03 0.0023878997
## lysoPC.a.C28.0_T5 3.794343e-02 5.972795e-02 3.942727e-02 0.0163230039
## lysoPC.a.C28.1_T5 -3.552208e-03 -1.714241e-03 8.940690e-03 0.0031638404
## PC.aa.C24.0_T5 -2.362515e-02 -4.718940e-04 8.798264e-03 -0.0275975449
## PC.aa.C28.1_T5 -1.014045e-02 -2.291068e-03 1.234597e-02 0.0036569985
## PC.aa.C30.0_T5 -4.025812e-02 1.146180e-02 2.671709e-02 -0.0109451415
## PC.aa.C32.0_T5 -1.305416e-02 -1.852370e-02 -5.022008e-02 -0.0380100985
## PC.aa.C32.1_T5 -1.564272e-01 1.756958e-02 3.156633e-02 0.0561304941
## PC.aa.C32.3_T5 -2.867420e-03 -1.426002e-03 5.411692e-03 0.0016981573
## PC.aa.C34.1_T5 -4.306572e-03 -2.731269e-02 -9.376047e-03 0.0071543826
## PC.aa.C34.2_T5 -3.688509e-02 -3.251400e-03 3.644399e-02 -0.0430441207
## PC.aa.C34.3_T5 -1.398913e-01 5.135844e-02 5.871286e-02 0.0058776565
## PC.aa.C34.4_T5 -1.475974e-02 4.617115e-03 1.204351e-02 -0.0009490277
## PC.aa.C36.0_T5 -1.498868e-02 -2.460533e-03 9.165472e-03 0.0021215915
## PC.aa.C36.1_T5 -3.495045e-02 -2.491547e-02 -4.181222e-02 0.0168199076
## PC.aa.C36.2_T5 -4.326090e-02 5.196599e-03 -1.022633e-02 0.0040416153
## PC.aa.C36.3_T5 -7.517671e-02 4.505375e-02 2.919006e-02 -0.0349186683
## PC.aa.C36.4_T5 1.019703e-02 -4.219500e-02 3.366874e-02 -0.0586223784
## PC.aa.C36.5_T5 -6.315968e-02 8.785641e-02 6.420561e-02 0.0193465031
## PC.aa.C38.0_T5 2.780755e-02 1.517900e-02 -2.002826e-02 0.0181399640
## PC.aa.C38.1_T5 -1.797375e-03 -4.507246e-03 -5.578676e-03 -0.0121219299
## PC.aa.C38.3_T5 -1.149923e-01 6.823213e-03 8.612151e-03 0.0129592670
## PC.aa.C38.4_T5 1.347900e-02 -3.448057e-02 -1.325481e-02 -0.0251950256
## PC.aa.C38.5_T5 4.063183e-02 9.058113e-03 -1.450735e-03 -0.0569493819
## PC.aa.C38.6_T5 1.305196e-02 3.971434e-02 3.326100e-02 0.0037503416
## PC.aa.C40.1_T5 3.289395e-02 -8.623366e-03 -1.000701e-02 -0.0124305464
## PC.aa.C40.2_T5 -1.118613e-02 -1.069594e-02 -6.004076e-05 0.0035016565
## PC.aa.C40.3_T5 -1.013637e-02 -1.099005e-02 2.626527e-03 0.0046237440
## PC.aa.C40.4_T5 -9.866928e-03 -1.940447e-02 -4.954589e-04 -0.0082103897
## PC.aa.C40.5_T5 1.911970e-03 -1.478236e-02 -1.829028e-02 -0.0362889705
## PC.aa.C40.6_T5 -1.849756e-02 4.335719e-02 8.295702e-03 0.0474317438
## PC.aa.C42.0_T5 -1.240998e-03 2.019969e-03 2.462554e-03 0.0021215176
## PC.aa.C42.1_T5 -1.806202e-03 6.061763e-04 3.402504e-03 0.0049084707
## PC.aa.C42.2_T5 -4.228066e-03 -3.552449e-03 4.633014e-03 0.0046101971
## PC.aa.C42.4_T5 -6.308198e-03 -6.863599e-03 3.560124e-03 0.0022740676
## PC.aa.C42.5_T5 -5.366168e-03 -2.930076e-03 6.013056e-03 0.0005530058
## PC.aa.C42.6_T5 4.071468e-02 3.551084e-02 7.770383e-02 0.0598464133
## PC.ae.C30.0_T5 4.291719e-02 -7.121238e-03 3.301150e-02 0.0543764595
## PC.ae.C32.1_T5 2.683900e-03 -2.988532e-03 -1.127892e-02 -0.0148835464
## PC.ae.C32.2_T5 -7.593506e-04 -7.632967e-04 4.510395e-05 0.0024565860
## PC.ae.C34.0_T5 -6.905260e-03 3.500301e-03 3.832511e-03 0.0031883212
## PC.ae.C34.1_T5 -8.218752e-04 5.505601e-03 -2.956941e-02 0.0112164182
## PC.ae.C34.2_T5 1.065364e-02 4.128241e-02 -3.252644e-02 -0.0481666502
## PC.ae.C34.3_T5 4.301486e-02 1.424191e-02 -1.555203e-02 -0.0811720803
## PC.ae.C36.0_T5 -6.463950e-04 -6.041231e-04 -4.904825e-03 0.0014831578
## PC.ae.C36.1_T5 -3.941162e-02 -2.702503e-02 -9.584730e-03 0.0214162134
## PC.ae.C36.2_T5 -2.949747e-02 2.446285e-02 1.740811e-02 0.0263046444
## PC.ae.C36.3_T5 9.495029e-03 1.092583e-02 -1.238406e-02 -0.0315957989
## PC.ae.C36.4_T5 1.455233e-02 -3.693983e-02 -7.105231e-02 -0.0452336949
## PC.ae.C36.5_T5 4.708954e-02 -3.352299e-02 -2.424009e-02 -0.0848383266
## PC.ae.C38.0_T5 -1.200264e-02 1.560144e-02 1.267460e-02 0.0077399859
## PC.ae.C38.2_T5 -2.622793e-02 -2.508219e-02 -7.236827e-03 0.0225878633
## PC.ae.C38.3_T5 -5.640747e-02 -2.004228e-02 -3.016690e-02 -0.0058085900
## PC.ae.C38.4_T5 8.018037e-03 -3.132280e-02 -1.202821e-02 -0.0248438082
## PC.ae.C38.5_T5 6.984241e-02 -6.275260e-02 -8.631091e-02 -0.0576176363
## PC.ae.C38.6_T5 2.406211e-02 -2.515467e-03 -1.670834e-02 -0.0181967745
## PC.ae.C40.1_T5 -4.490480e-03 -7.113942e-03 2.382028e-03 -0.0028566607
## PC.ae.C40.2_T5 -1.410563e-02 -5.020531e-03 -6.118382e-03 0.0103271885
## PC.ae.C40.3_T5 -4.128023e-02 -2.191925e-02 -3.215633e-02 -0.0029269174
## PC.ae.C40.4_T5 -2.057014e-02 -2.521142e-02 -2.237836e-02 -0.0063500844
## PC.ae.C40.5_T5 -1.445916e-02 -4.230486e-02 -3.935509e-02 -0.0219391199
## PC.ae.C40.6_T5 1.045541e-02 5.053656e-03 1.777008e-05 -0.0085295768
## PC.ae.C42.1_T5 -7.886287e-03 -5.319467e-03 2.233230e-03 0.0020880933
## PC.ae.C42.2_T5 -5.663892e-03 5.160064e-04 1.562981e-03 0.0033011567
## PC.ae.C42.3_T5 -4.678175e-03 -5.246893e-03 1.283646e-04 0.0068582778
## PC.ae.C42.4_T5 -7.433297e-03 -4.612452e-03 1.953919e-03 0.0002139039
## PC.ae.C42.5_T5 -5.808928e-03 -1.698748e-02 -3.294375e-02 -0.0059125315
## PC.ae.C44.3_T5 -4.963524e-03 -3.838780e-03 4.558069e-03 0.0037987458
## PC.ae.C44.4_T5 -4.656586e-03 2.410085e-03 5.014143e-03 0.0012256193
## PC.ae.C44.5_T5 1.797740e-02 1.157092e-02 -8.220314e-03 0.0049614066
## PC.ae.C44.6_T5 7.048495e-03 8.400843e-03 8.375004e-04 -0.0009822000
## SM..OH..C14.1_T5 2.897710e-02 1.112334e-02 -3.324202e-04 0.0157039796
## SM..OH..C16.1_T5 4.470688e-03 4.904259e-03 5.222737e-03 0.0053724613
## SM..OH..C22.1_T5 -2.398802e-02 -1.090786e-03 4.819043e-02 -0.0001437126
## SM..OH..C22.2_T5 -3.152649e-03 6.724051e-03 3.099522e-02 0.0354596196
## SM..OH..C24.1_T5 -2.512636e-03 8.914316e-04 9.459098e-03 0.0007749265
## SM.C16.0_T5 4.042694e-02 -3.327086e-02 -2.713603e-02 -0.0529319062
## SM.C16.1_T5 6.674743e-02 -1.007469e-01 -5.995091e-02 0.0134431083
## SM.C18.0_T5 3.709264e-03 -5.553475e-02 -1.426900e-02 -0.0303357430
## SM.C18.1_T5 5.455986e-02 -8.278639e-02 -3.939433e-02 0.0416899192
## SM.C20.2_T5 -3.669526e-03 -1.460582e-04 8.291470e-03 0.0010177266
## SM.C24.0_T5 -4.985417e-02 -1.554525e-02 7.993107e-02 -0.0226156245
## SM.C24.1_T5 2.046299e-02 -2.194082e-02 2.002126e-02 -0.0404614627
## PC13 PC14 PC15 PC16
## GLU_T0 5.141493e-02 -7.219548e-02 -5.962212e-02 -2.705124e-02
## INS_T0 -5.384979e-02 1.128731e-02 3.458168e-02 4.471072e-02
## HOMA_T0 -3.760427e-02 -1.613231e-02 1.811031e-02 1.248858e-02
## HBA1C_T0 3.474008e-02 -2.580934e-02 -3.194377e-02 -7.560693e-03
## HBA1C.mmol.mol_T0 8.374654e-02 -5.809960e-02 -4.806977e-02 -2.526540e-02
## PESO_T0 -1.950702e-02 -8.854584e-03 4.051256e-02 6.041467e-02
## bmi_T0 -3.245784e-04 -2.833772e-02 6.593482e-02 3.441530e-02
## CC_T0 -3.910616e-03 1.304292e-03 -6.995302e-03 3.414125e-03
## CINT_T0 -1.712961e-02 -2.747807e-02 4.440789e-02 3.862337e-02
## CAD_T0 7.429343e-02 -4.922629e-02 6.012169e-02 3.671128e-02
## TAD_T0 1.019066e-01 2.601276e-03 -5.922777e-04 -1.511037e-02
## TAS_T0 1.366959e-02 1.708692e-02 1.672540e-02 -1.675028e-02
## TG_T0 2.058515e-02 4.920415e-02 -6.785753e-02 -5.173345e-02
## COL_T0 -4.732177e-03 6.335156e-02 -1.557457e-02 1.380372e-02
## LDL_T0 -4.103886e-02 8.649787e-02 -9.259378e-03 3.747076e-02
## HDL_T0 8.695766e-02 -4.221359e-02 2.079271e-02 9.428390e-03
## VLDL_T0 2.063367e-02 4.976862e-02 -6.934742e-02 -5.238978e-02
## PCR_T0 8.490935e-02 4.475327e-02 -1.689150e-01 7.079026e-02
## LEP_T0 -2.383195e-02 -7.471570e-03 1.915333e-02 2.717318e-02
## ADIPO_T0 9.950859e-03 4.122024e-02 2.048858e-02 2.142389e-02
## GOT_T0 2.720371e-02 -1.134246e-01 8.506484e-02 -2.945194e-02
## GPT_T0 7.478975e-02 -2.455289e-02 5.919745e-02 -7.179674e-02
## GGT_T0 -4.027772e-02 -9.503562e-02 -3.859045e-02 -5.213714e-02
## URICO_T0 -3.424369e-02 -1.167318e-02 -1.642718e-02 -9.566314e-03
## CREAT_T0 1.756781e-03 6.099136e-03 -1.250414e-02 1.116741e-03
## UREA_T0 1.484683e-02 3.438809e-02 -1.489944e-01 2.835839e-02
## HIERRO_T0 2.570517e-02 1.355956e-01 1.262175e-01 -2.559464e-02
## TRANSF_T0 8.270035e-02 -3.057057e-02 -9.537038e-03 2.557368e-03
## FERR_T0 -1.645238e-01 9.168878e-02 4.144697e-02 -1.285887e-01
## Ile_T0 2.977558e-03 -3.461059e-02 -3.184301e-02 2.321505e-02
## Leu_T0 1.405504e-02 -3.608303e-02 -4.971406e-02 -3.799123e-03
## Val_T0 -1.350105e-03 -5.719301e-02 -4.167736e-02 -5.918682e-02
## Ala_T0 1.385045e-02 -5.650804e-02 -7.000370e-03 -4.254846e-02
## Pro_T0 -5.068030e-02 5.302423e-03 1.367785e-02 2.876428e-02
## Gly_T0 -3.631442e-02 3.623082e-03 -5.686230e-02 4.272030e-02
## Ser_T0 3.657978e-02 3.271255e-02 8.147758e-02 3.907260e-02
## Trp_T0 4.985822e-02 1.336987e-02 -3.466175e-02 -8.932330e-02
## Phe_T0 6.113769e-02 -7.751617e-02 -3.761134e-02 6.109606e-02
## Met_T0 1.393038e-02 -2.870804e-02 -2.953293e-02 -5.203493e-02
## Orn_T0 -1.492541e-02 -3.306024e-03 -3.535536e-02 -1.458473e-02
## Arg_T0 1.089058e-01 7.726472e-03 1.703543e-02 -1.406654e-02
## His_T0 4.922757e-02 2.834948e-02 9.399472e-03 -2.588782e-02
## Asn_T0 2.389645e-03 7.580417e-02 -7.769315e-02 7.057634e-02
## Asp_T0 2.502621e-02 -1.010975e-02 -6.375996e-03 -1.646077e-03
## Glu_T0 3.843436e-02 -7.249976e-03 -1.235150e-02 -3.494354e-02
## Gln_T0 -3.142882e-02 2.800834e-02 -2.493432e-04 2.869976e-02
## Cit_T0 2.629486e-02 9.355353e-02 -7.187075e-02 5.349005e-02
## Tyr_T0 1.831215e-02 -8.003535e-02 3.770730e-03 2.836779e-02
## Thr_T0 6.703424e-02 9.738595e-02 -1.592595e-02 7.126582e-02
## Lys_T0 2.296256e-02 9.594787e-03 4.366680e-02 -2.067158e-02
## Creatinine_T0 3.046334e-02 1.171250e-01 -1.254451e-01 1.017965e-01
## Kynurenine_T0 3.260037e-02 -5.683234e-03 -2.720072e-02 2.994437e-03
## Putrescine_T0 8.177455e-02 7.379027e-02 5.072922e-04 -4.402862e-02
## Sarcosine_T0 3.295754e-03 1.146212e-01 -1.005133e-02 8.919530e-02
## Serotonin_T0 1.032980e-02 -1.047646e-02 3.837678e-02 -9.569734e-05
## Taurine_T0 -1.396424e-02 3.356557e-02 -3.524098e-02 2.554831e-02
## SDMA_T0 7.131088e-03 8.455406e-03 -1.045002e-02 4.227258e-03
## C0_T0 7.460148e-03 -2.917975e-02 4.032854e-02 -1.521683e-03
## C2_T0 -1.838454e-02 6.664284e-03 -1.491165e-02 -2.560137e-02
## C3.OH_T0 2.196000e-03 6.413780e-04 -4.093030e-03 -2.088462e-03
## C6..C4.1.DC._T0 1.091920e-01 1.623566e-01 3.224757e-03 3.403693e-02
## C5.DC..C6.OH._T0 8.192831e-02 -5.073287e-02 -2.874541e-02 6.358915e-03
## C7.DC_T0 5.509703e-02 3.485395e-02 2.575489e-03 -8.048818e-02
## C8_T0 8.291835e-03 -6.725543e-05 -4.635540e-03 -2.860514e-04
## C10_T0 4.702815e-03 -1.958622e-03 -2.691206e-03 -2.269376e-03
## C10.1_T0 3.462443e-04 2.190417e-04 -4.868716e-03 -2.038216e-03
## C10.2_T0 2.362772e-03 1.769956e-03 -4.483577e-03 -1.283480e-03
## C14.1_T0 8.708582e-04 1.407440e-03 -4.093697e-03 -4.056312e-04
## C14.2_T0 1.115296e-03 1.711299e-03 -4.297274e-03 -9.486105e-04
## C16.1_T0 1.055483e-03 2.362971e-03 -4.741371e-03 -2.263651e-04
## C16.2_T0 2.496446e-04 1.086648e-03 -5.070221e-03 -1.531425e-03
## C16.2.OH_T0 3.901981e-04 1.565536e-03 -4.927108e-03 -1.519926e-03
## C18.1_T0 2.763410e-04 2.179048e-03 -5.165564e-03 -1.377643e-03
## C18.1.OH_T0 1.248136e-04 1.452536e-03 -5.236728e-03 -1.626770e-03
## C18.2_T0 -5.130158e-04 1.787879e-03 -5.097074e-03 -1.708657e-03
## lysoPC.a.C16.0_T0 -3.785797e-02 4.808480e-02 1.634566e-02 -5.667091e-03
## lysoPC.a.C16.1_T0 -2.034498e-02 6.877860e-03 -1.269925e-04 -9.489678e-04
## lysoPC.a.C17.0_T0 -5.325760e-03 2.234076e-02 -1.298986e-03 2.507557e-03
## lysoPC.a.C18.0_T0 -6.339316e-02 1.746026e-02 4.345781e-02 6.637351e-03
## lysoPC.a.C18.1_T0 -4.051902e-02 3.322446e-02 2.689819e-02 1.155800e-02
## lysoPC.a.C18.2_T0 -5.716420e-02 5.851120e-02 6.031152e-02 7.842613e-05
## lysoPC.a.C20.3_T0 -7.093241e-03 -2.216467e-02 3.182628e-03 -3.258144e-02
## lysoPC.a.C20.4_T0 -3.021985e-02 1.223304e-01 -2.973055e-02 -3.844636e-02
## lysoPC.a.C24.0_T0 -1.678607e-03 3.136869e-03 2.892817e-03 -2.784118e-03
## lysoPC.a.C26.0_T0 5.699692e-02 1.132216e-03 -1.561724e-04 3.122316e-02
## lysoPC.a.C26.1_T0 2.423102e-03 4.248632e-03 8.650749e-04 -3.366425e-04
## lysoPC.a.C28.0_T0 4.740925e-02 -3.950280e-02 8.292573e-02 -3.544344e-02
## lysoPC.a.C28.1_T0 2.883367e-03 3.105138e-03 1.313087e-03 5.328662e-04
## PC.aa.C24.0_T0 3.464479e-02 -6.356230e-02 6.579008e-02 -4.524986e-02
## PC.aa.C28.1_T0 2.479188e-02 -2.432316e-04 1.093844e-02 -9.499456e-03
## PC.aa.C30.0_T0 1.249357e-02 -1.791912e-02 -1.231911e-02 -9.342000e-03
## PC.aa.C32.0_T0 -4.888838e-03 -1.320407e-02 -6.853638e-03 -1.165747e-03
## PC.aa.C32.1_T0 -1.200132e-04 -1.269324e-01 -2.210905e-02 -6.049645e-02
## PC.aa.C32.3_T0 -4.713011e-04 1.958680e-04 -4.580818e-03 -7.200718e-04
## PC.aa.C34.1_T0 3.660730e-03 -1.073689e-01 1.267320e-03 -5.185610e-02
## PC.aa.C34.2_T0 6.598531e-03 -4.612110e-02 6.178844e-02 -1.040059e-02
## PC.aa.C34.3_T0 -9.492147e-03 -6.104216e-02 1.400844e-02 -5.505875e-02
## PC.aa.C34.4_T0 9.884340e-04 1.386741e-03 -1.391656e-02 -1.577393e-02
## PC.aa.C36.0_T0 -1.893221e-03 -6.569817e-03 7.988761e-03 1.116967e-02
## PC.aa.C36.1_T0 -1.836230e-02 -1.202581e-01 1.483459e-02 8.071728e-03
## PC.aa.C36.2_T0 -2.103913e-02 -8.933309e-02 8.983268e-02 -1.817039e-02
## PC.aa.C36.3_T0 2.522455e-02 -6.618847e-02 2.737256e-02 -4.184537e-02
## PC.aa.C36.4_T0 -1.849946e-02 1.143852e-01 -6.645978e-02 -6.613121e-02
## PC.aa.C36.5_T0 4.037981e-02 -4.228888e-02 -6.405307e-02 1.197798e-02
## PC.aa.C38.0_T0 -8.975539e-03 -3.282948e-02 1.193377e-03 2.558358e-02
## PC.aa.C38.1_T0 3.867578e-02 6.783972e-02 5.575626e-03 2.013685e-02
## PC.aa.C38.3_T0 -1.917174e-02 -1.277987e-01 1.219045e-02 -5.094172e-02
## PC.aa.C38.4_T0 -5.618505e-02 5.595347e-02 -8.085370e-02 -6.585803e-02
## PC.aa.C38.5_T0 -2.170904e-02 1.608613e-03 -9.419634e-02 -3.487353e-02
## PC.aa.C38.6_T0 1.394747e-02 3.551615e-02 -1.300633e-02 -3.463032e-02
## PC.aa.C40.1_T0 3.479592e-02 -2.432720e-02 -6.761821e-03 -4.286994e-02
## PC.aa.C40.2_T0 3.989885e-03 7.576605e-03 5.120283e-03 1.093685e-02
## PC.aa.C40.3_T0 3.177388e-04 4.922704e-03 5.720531e-03 9.938541e-03
## PC.aa.C40.4_T0 -1.186984e-02 4.786807e-03 -3.218408e-03 -1.141253e-02
## PC.aa.C40.5_T0 -2.024552e-02 -2.258866e-03 -2.040589e-02 -3.999110e-02
## PC.aa.C40.6_T0 -3.176927e-02 -5.054418e-02 -4.215727e-02 -1.228442e-02
## PC.aa.C42.0_T0 8.810937e-04 3.564343e-03 -5.980087e-03 8.268680e-03
## PC.aa.C42.1_T0 2.933362e-04 2.948889e-03 -3.465918e-03 3.664683e-03
## PC.aa.C42.2_T0 -1.557129e-04 2.241100e-03 1.374323e-03 5.607611e-03
## PC.aa.C42.4_T0 -4.239552e-04 6.360258e-03 1.263988e-04 5.065807e-03
## PC.aa.C42.5_T0 -1.830270e-03 2.568251e-03 -2.362554e-03 2.285540e-03
## PC.aa.C42.6_T0 4.782772e-02 5.200264e-03 -6.553857e-02 2.245861e-02
## PC.ae.C30.0_T0 1.696284e-03 -3.931237e-04 -4.151497e-03 -1.520336e-04
## PC.ae.C32.1_T0 3.134637e-03 -1.795266e-02 2.432973e-03 3.050484e-03
## PC.ae.C32.2_T0 2.634999e-03 -5.772320e-03 -8.040432e-04 8.742123e-04
## PC.ae.C34.0_T0 2.598012e-03 -2.079743e-03 -3.583714e-03 -1.077498e-03
## PC.ae.C34.1_T0 2.642443e-02 -3.379091e-02 1.447874e-02 1.149519e-02
## PC.ae.C34.2_T0 -9.762540e-03 -5.300837e-02 4.123903e-02 -2.894434e-02
## PC.ae.C34.3_T0 -9.063899e-03 -7.928826e-02 3.921920e-02 -8.313935e-03
## PC.ae.C36.0_T0 -2.885341e-04 -2.701254e-03 3.509939e-04 6.585892e-03
## PC.ae.C36.1_T0 1.478402e-02 9.333740e-03 1.730939e-02 1.594435e-02
## PC.ae.C36.2_T0 1.943157e-02 4.412193e-04 3.170225e-02 1.551789e-02
## PC.ae.C36.3_T0 -4.903614e-03 -5.947667e-02 2.760065e-02 -2.298529e-03
## PC.ae.C36.4_T0 -3.496347e-02 1.883937e-03 8.249445e-03 -1.571874e-02
## PC.ae.C36.5_T0 -4.118014e-02 -4.227569e-03 -2.330245e-02 -2.584864e-02
## PC.ae.C38.0_T0 -2.625893e-03 -1.083361e-02 -8.322198e-03 -6.398684e-03
## PC.ae.C38.2_T0 2.674084e-03 1.390881e-02 2.233899e-02 2.969783e-02
## PC.ae.C38.3_T0 3.265775e-02 -7.647747e-03 -1.170029e-03 -1.692200e-02
## PC.ae.C38.4_T0 5.276245e-03 4.549940e-02 -2.076707e-02 -6.490052e-03
## PC.ae.C38.5_T0 -2.622850e-02 8.434287e-03 -8.540692e-03 2.348713e-02
## PC.ae.C38.6_T0 -1.643416e-02 -2.462850e-02 -1.356813e-02 8.392318e-03
## PC.ae.C40.1_T0 -1.740521e-03 6.089795e-03 1.989327e-03 8.460741e-07
## PC.ae.C40.2_T0 1.059935e-02 9.476409e-03 2.397696e-03 1.223490e-02
## PC.ae.C40.3_T0 2.129185e-02 -3.818543e-03 2.147321e-03 -6.602165e-03
## PC.ae.C40.4_T0 1.414097e-02 7.741999e-03 1.958565e-03 2.444524e-03
## PC.ae.C40.5_T0 1.352562e-02 1.351781e-02 -7.399324e-04 1.196612e-02
## PC.ae.C40.6_T0 6.379463e-03 1.122148e-02 -9.504315e-03 5.840895e-03
## PC.ae.C42.1_T0 2.082964e-03 6.084880e-03 4.218070e-03 4.440637e-03
## PC.ae.C42.2_T0 1.181774e-03 1.747407e-03 1.905149e-03 9.159710e-03
## PC.ae.C42.3_T0 6.216542e-04 3.381969e-03 6.001378e-03 1.284790e-02
## PC.ae.C42.4_T0 1.316112e-03 2.634260e-03 1.254553e-03 9.075825e-03
## PC.ae.C42.5_T0 6.101065e-03 1.214696e-02 -1.039876e-02 1.533583e-02
## PC.ae.C44.3_T0 7.964914e-04 2.566270e-03 -5.017488e-04 2.924902e-03
## PC.ae.C44.4_T0 -8.061217e-04 -3.074091e-03 -3.626500e-03 3.578851e-03
## PC.ae.C44.5_T0 -1.126738e-03 8.682700e-03 -2.377922e-02 1.782739e-02
## PC.ae.C44.6_T0 -2.893364e-03 1.105769e-02 -1.022339e-02 8.450013e-03
## SM..OH..C14.1_T0 1.471195e-02 3.597448e-03 1.504151e-02 3.490243e-04
## SM..OH..C16.1_T0 1.323938e-02 1.136795e-02 5.238075e-03 6.220306e-03
## SM..OH..C22.1_T0 1.020686e-02 2.720062e-02 2.769171e-02 -1.701451e-03
## SM..OH..C22.2_T0 2.777604e-02 3.944366e-03 3.986884e-02 1.529814e-02
## SM..OH..C24.1_T0 4.035855e-03 4.010034e-03 -3.159141e-03 1.103572e-03
## SM.C16.0_T0 8.966225e-03 5.011620e-02 8.111722e-02 7.177895e-02
## SM.C16.1_T0 -4.168141e-03 -1.814328e-02 7.120288e-02 2.479448e-02
## SM.C18.0_T0 3.881198e-02 4.017650e-02 4.598871e-02 7.248017e-02
## SM.C18.1_T0 2.492715e-02 2.137486e-02 5.242820e-02 4.495264e-02
## SM.C20.2_T0 9.551794e-04 3.736142e-03 -4.984414e-03 -9.834921e-04
## SM.C24.0_T0 -3.210074e-02 2.142028e-02 3.378150e-02 3.508423e-02
## SM.C24.1_T0 7.657633e-03 3.024682e-02 4.692087e-03 7.839615e-02
## MEDDM_T2 -6.326798e-04 1.059160e-03 -5.539757e-03 -1.473953e-03
## MEDCOL_T2 -6.326798e-04 1.059160e-03 -5.539757e-03 -1.473953e-03
## MEDINF_T2 -9.121179e-04 -9.586752e-03 -8.041185e-03 1.039645e-02
## MEDHTA_T2 8.061119e-04 1.227364e-02 -4.983204e-03 -1.782546e-02
## GLU_T2 9.350781e-03 -6.278613e-02 -2.369142e-02 -4.506491e-03
## INS_T2 -8.617130e-02 -5.526547e-02 3.991158e-02 -4.610161e-02
## HOMA_T2 -5.565246e-02 -4.599978e-02 1.971273e-02 -2.910912e-02
## HBA1C_T2 7.862005e-03 -1.729714e-02 -2.986157e-02 -6.809452e-03
## HBA1C.mmol.mol_T2 8.137538e-03 -4.546425e-02 -5.886404e-02 -3.072465e-02
## PESO_T2 -5.438108e-02 -2.530322e-02 1.539625e-02 4.132320e-02
## bmi_T2 -3.165464e-02 -5.006560e-02 4.964663e-02 7.448623e-03
## CC_T2 -2.946218e-03 1.025572e-03 -9.422958e-03 9.332539e-04
## CINT_T2 -4.400599e-02 -3.305180e-02 1.025548e-02 2.355471e-02
## CAD_T2 6.756681e-03 -5.160421e-02 3.408813e-02 1.993775e-02
## TAD_T2 1.083174e-02 7.266658e-02 -3.619307e-02 -7.187794e-04
## TAS_T2 1.467240e-02 5.204716e-02 -1.080706e-03 1.248665e-02
## TG_T2 -1.893121e-02 -1.103048e-02 -9.115766e-02 -7.488817e-02
## COL_T2 -3.946427e-02 -1.768500e-02 -2.769848e-02 2.364854e-02
## LDL_T2 -3.110856e-02 -2.636761e-02 -6.486996e-02 1.775975e-03
## HDL_T2 3.263405e-02 -1.288514e-02 7.173996e-02 7.366983e-03
## VLDL_T2 -6.905812e-03 2.311292e-03 -5.320807e-02 -9.604348e-02
## PCR_T2 5.856280e-02 3.980025e-02 -1.919771e-01 7.815210e-02
## LEP_T2 -3.974982e-02 2.537677e-02 2.695993e-02 3.397929e-03
## ADIPO_T2 -3.786693e-02 -5.546065e-03 1.578712e-02 4.852057e-02
## GOT_T2 4.914469e-02 -4.697854e-02 1.271663e-01 -4.751020e-02
## GPT_T2 1.821548e-02 3.053827e-02 2.038778e-02 -8.054915e-02
## GGT_T2 -1.222554e-01 -1.528576e-01 -1.255513e-01 -3.409508e-02
## URICO_T2 -4.643969e-02 -2.643273e-02 -3.283768e-02 -1.010573e-02
## CREAT_T2 -2.408870e-03 5.417166e-03 -1.437668e-02 3.550719e-03
## UREA_T2 -1.256310e-02 7.118011e-02 -1.280093e-01 -2.501470e-02
## HIERRO_T2 -1.184192e-02 4.115598e-02 1.038736e-01 -6.096987e-02
## TRANSF_T2 7.376553e-02 6.868813e-03 1.468806e-04 5.878652e-02
## FERR_T2 -1.632554e-01 9.183291e-02 -8.653558e-03 -1.198349e-01
## Ile_T2 1.003857e-01 -9.713288e-02 -7.046952e-02 -4.035576e-02
## Leu_T2 4.144123e-02 -9.722142e-02 -2.195430e-02 4.406444e-03
## Val_T2 3.593813e-02 -7.803513e-02 -3.253781e-02 -4.633412e-02
## Ala_T2 4.003189e-02 -3.243588e-03 5.327163e-02 2.174263e-02
## Pro_T2 -3.572455e-02 4.700785e-02 5.104814e-02 -1.564948e-02
## Gly_T2 -8.513115e-03 -3.501778e-02 -4.605620e-02 -9.253253e-03
## Ser_T2 -2.139544e-03 -9.178226e-03 8.304373e-02 6.659456e-02
## Trp_T2 -1.673609e-02 -3.650011e-02 -2.192451e-02 -2.031219e-03
## Phe_T2 4.236728e-02 -1.124732e-01 1.164182e-02 9.561406e-02
## Met_T2 9.452130e-02 2.295926e-02 2.915914e-02 -1.407375e-01
## Orn_T2 -1.031977e-01 7.095966e-04 3.775721e-02 8.640909e-02
## Arg_T2 6.139015e-02 -1.879644e-02 1.188963e-02 -3.675991e-02
## His_T2 -1.122724e-02 -3.416954e-02 3.734464e-02 1.099532e-02
## Asn_T2 1.263931e-02 1.121431e-02 -3.413093e-02 1.094542e-02
## Asp_T2 8.035581e-02 8.681272e-02 -3.481744e-03 7.455982e-02
## Glu_T2 1.039534e-02 -5.446109e-02 -5.485602e-02 6.545485e-02
## Gln_T2 -8.750061e-03 9.716368e-03 7.335052e-03 -7.499125e-02
## Cit_T2 -3.539220e-02 4.675906e-02 1.818760e-02 1.923396e-02
## Tyr_T2 1.318725e-02 -6.008389e-02 6.994963e-02 2.502266e-02
## Thr_T2 9.025659e-02 7.646080e-02 3.731938e-02 2.537751e-02
## Lys_T2 -4.649238e-02 3.013603e-02 6.063760e-02 2.477337e-02
## Creatinine_T2 6.875635e-02 -6.931724e-03 -4.954919e-02 4.897313e-02
## Kynurenine_T2 8.403295e-03 -1.442436e-02 -1.046153e-02 6.039147e-03
## Putrescine_T2 -4.745542e-02 3.605097e-02 -1.104985e-01 1.164949e-04
## Sarcosine_T2 1.000703e-01 1.348478e-02 1.372094e-03 9.617832e-02
## Serotonin_T2 3.630437e-02 1.943064e-01 7.791274e-02 -1.354449e-01
## Taurine_T2 5.321597e-02 -3.649554e-02 -2.459143e-02 5.150173e-02
## SDMA_T2 3.531896e-02 -1.253089e-02 -1.044710e-02 -5.990132e-03
## C0_T2 -1.500933e-01 1.923320e-02 -6.641469e-03 1.045569e-02
## C2_T2 2.386822e-02 -2.627650e-03 1.325707e-02 -5.877731e-02
## C3.OH_T2 -1.660150e-04 5.662184e-04 -6.000623e-03 1.376144e-03
## C6..C4.1.DC._T2 5.991282e-02 -3.819600e-03 2.804719e-02 8.562766e-02
## C5.DC..C6.OH._T2 -1.594042e-02 4.360766e-04 -1.815285e-02 7.168817e-02
## C7.DC_T2 -9.896347e-02 -2.357557e-03 -2.298620e-02 2.240515e-02
## C8_T2 -1.815828e-04 3.271434e-03 -2.341619e-03 2.541412e-03
## C10_T2 -3.990294e-04 3.668712e-03 -1.983937e-03 -5.231246e-04
## C10.1_T2 -3.091855e-04 2.014319e-03 -4.844262e-03 -3.821902e-04
## C10.2_T2 8.728725e-04 2.646955e-03 -5.035899e-03 8.223303e-04
## C14.1_T2 -3.207274e-04 4.582067e-04 -3.996584e-03 -1.160395e-03
## C14.2_T2 9.360768e-04 1.351992e-03 -4.753815e-03 1.079183e-06
## C16.1_T2 4.533145e-04 1.130795e-03 -5.501983e-03 -6.033391e-05
## C16.2_T2 -2.749975e-04 1.027599e-03 -5.480526e-03 -1.049023e-03
## C16.2.OH_T2 -3.902568e-04 1.017807e-03 -5.462334e-03 -1.247418e-03
## C18.1_T2 1.333672e-03 -1.334800e-03 -4.967531e-03 -7.307867e-04
## C18.1.OH_T2 9.846712e-05 1.523486e-03 -5.403214e-03 -9.496299e-04
## C18.2_T2 8.949679e-04 1.259238e-03 -5.196709e-03 1.026003e-03
## lysoPC.a.C14.0_T2 -9.365629e-02 -5.840007e-02 -5.740143e-02 -1.368262e-01
## lysoPC.a.C16.0_T2 -9.533823e-02 5.666791e-03 -5.679068e-02 6.414596e-02
## lysoPC.a.C16.1_T2 -6.789421e-02 1.463903e-02 -3.346351e-02 3.302474e-02
## lysoPC.a.C17.0_T2 -3.040921e-02 2.437687e-03 -2.037008e-02 6.281676e-03
## lysoPC.a.C18.0_T2 -9.787438e-02 -1.008583e-02 -3.263450e-02 2.061985e-03
## lysoPC.a.C18.1_T2 -1.302669e-01 -3.204378e-03 -4.109207e-02 7.564884e-03
## lysoPC.a.C18.2_T2 -8.185391e-02 1.750199e-03 -2.279847e-02 2.038532e-02
## lysoPC.a.C20.3_T2 -4.623137e-02 -1.787683e-05 -1.310579e-02 9.188645e-04
## lysoPC.a.C20.4_T2 -5.547825e-02 3.456941e-02 -6.265633e-02 -2.464685e-02
## lysoPC.a.C24.0_T2 -5.621334e-03 1.355849e-03 -5.252476e-03 6.390051e-03
## lysoPC.a.C26.0_T2 1.530361e-02 -5.523155e-02 2.658450e-03 2.390633e-02
## lysoPC.a.C26.1_T2 -4.003085e-03 1.124614e-03 -3.835603e-03 2.734087e-03
## lysoPC.a.C28.0_T2 8.088059e-03 -1.460960e-02 3.324420e-02 -1.022739e-01
## lysoPC.a.C28.1_T2 -9.411705e-03 5.014138e-04 -2.751737e-03 1.069941e-02
## PC.aa.C24.0_T2 3.778500e-03 2.058863e-02 -6.064652e-02 -1.744685e-02
## PC.aa.C28.1_T2 1.759698e-02 -3.254769e-03 7.779857e-03 1.889940e-03
## PC.aa.C30.0_T2 1.290643e-02 3.718361e-03 8.994413e-03 3.644523e-03
## PC.aa.C32.0_T2 2.262820e-02 -1.859553e-02 2.569098e-02 -7.021967e-03
## PC.aa.C32.1_T2 -1.754019e-02 1.226913e-02 8.643266e-03 3.079659e-02
## PC.aa.C32.3_T2 4.686812e-04 1.839891e-04 -3.272473e-03 1.749659e-04
## PC.aa.C34.1_T2 -3.994193e-03 -4.627020e-02 -1.234824e-02 -4.846945e-02
## PC.aa.C34.2_T2 3.252849e-02 -2.524561e-02 2.010386e-02 -2.794630e-02
## PC.aa.C34.3_T2 -3.908675e-02 2.151033e-02 -1.646772e-02 1.637816e-02
## PC.aa.C34.4_T2 -2.316208e-03 3.320647e-03 -6.341178e-03 -1.822269e-03
## PC.aa.C36.0_T2 -1.840152e-02 -1.302808e-02 -7.246843e-03 1.532394e-02
## PC.aa.C36.1_T2 -5.545692e-02 -7.181744e-03 1.969921e-02 -2.056611e-02
## PC.aa.C36.2_T2 -3.138339e-02 -9.280604e-03 3.175182e-02 -3.678299e-02
## PC.aa.C36.3_T2 -3.275081e-02 -5.068542e-03 1.166071e-02 -9.815208e-04
## PC.aa.C36.4_T2 8.678055e-02 -1.352424e-03 -1.163083e-02 -1.120463e-01
## PC.aa.C36.5_T2 8.908044e-02 -5.656334e-02 -3.658508e-02 -6.173624e-02
## PC.aa.C38.0_T2 -9.998351e-03 -2.956397e-02 -1.810016e-03 -9.893530e-03
## PC.aa.C38.1_T2 -4.603703e-02 -3.823576e-02 -2.632578e-02 -2.270047e-02
## PC.aa.C38.3_T2 -3.199977e-02 -2.375347e-02 1.927997e-02 -1.871984e-02
## PC.aa.C38.4_T2 2.281620e-03 -1.174480e-02 -2.538176e-02 -1.231914e-01
## PC.aa.C38.5_T2 -2.441759e-02 7.440815e-04 -3.661474e-02 -7.519680e-02
## PC.aa.C38.6_T2 5.222342e-02 -5.479544e-02 -1.780555e-03 -1.147982e-01
## PC.aa.C40.1_T2 -2.027133e-02 -3.132274e-02 3.445065e-02 -6.237272e-02
## PC.aa.C40.2_T2 -1.978470e-02 -1.109860e-02 -1.055398e-02 2.874791e-02
## PC.aa.C40.3_T2 -2.594864e-02 -9.207968e-03 -9.741338e-03 2.974194e-02
## PC.aa.C40.4_T2 -2.514054e-02 1.150986e-03 -1.100483e-02 6.660198e-03
## PC.aa.C40.5_T2 -3.716915e-02 2.400775e-03 -2.501222e-02 -4.335309e-02
## PC.aa.C40.6_T2 1.908357e-02 -4.321728e-02 -1.675011e-02 -9.526325e-02
## PC.aa.C42.0_T2 -6.902895e-03 -3.196903e-03 -8.762809e-03 7.819547e-03
## PC.aa.C42.1_T2 -7.872628e-03 -1.620072e-03 -6.668701e-03 6.652441e-03
## PC.aa.C42.2_T2 -1.181522e-02 -3.377043e-03 -6.588114e-03 1.595073e-02
## PC.aa.C42.4_T2 -6.980322e-03 -1.353018e-03 -7.857742e-03 6.389045e-03
## PC.aa.C42.5_T2 -5.541659e-03 -5.396577e-04 -6.042674e-03 1.870209e-03
## PC.aa.C42.6_T2 -1.886848e-02 -4.284424e-02 -1.651880e-02 4.457640e-02
## PC.ae.C30.0_T2 -3.710566e-02 -6.573013e-02 3.240951e-02 2.259127e-03
## PC.ae.C32.1_T2 9.176575e-03 -1.305609e-02 4.993385e-04 -5.019867e-03
## PC.ae.C32.2_T2 -1.360720e-03 -3.032428e-03 -3.159555e-03 6.904608e-05
## PC.ae.C34.0_T2 5.155635e-03 5.774620e-04 -1.837535e-03 -1.472085e-03
## PC.ae.C34.1_T2 -1.021868e-02 -1.319330e-03 9.949986e-03 1.211967e-02
## PC.ae.C34.2_T2 -9.272281e-03 -1.187913e-02 4.458355e-03 -3.714092e-03
## PC.ae.C34.3_T2 9.962916e-03 -3.083606e-02 3.980064e-03 -1.181164e-02
## PC.ae.C36.0_T2 -1.665937e-03 -4.042974e-03 -7.377642e-03 1.444906e-03
## PC.ae.C36.1_T2 -5.998657e-02 -2.539602e-02 -1.598709e-02 7.600106e-02
## PC.ae.C36.2_T2 -2.034888e-02 -1.144047e-02 -7.447458e-05 1.552485e-02
## PC.ae.C36.3_T2 -1.390479e-02 -9.316155e-03 1.189622e-02 9.211049e-04
## PC.ae.C36.4_T2 9.315405e-03 5.966908e-03 5.608696e-03 -2.377272e-02
## PC.ae.C36.5_T2 3.439986e-03 -7.316017e-03 -1.203053e-02 -4.747148e-02
## PC.ae.C38.0_T2 -1.629010e-02 -2.186771e-03 -1.264818e-02 -1.036690e-02
## PC.ae.C38.2_T2 -4.410727e-02 -2.718390e-02 -1.119659e-02 6.464701e-02
## PC.ae.C38.3_T2 -3.909529e-02 -2.464807e-02 -7.035601e-03 6.908495e-02
## PC.ae.C38.4_T2 2.274098e-02 1.370104e-02 5.389871e-03 -1.923119e-02
## PC.ae.C38.5_T2 1.329868e-02 -8.180840e-03 2.399916e-02 -2.418652e-02
## PC.ae.C38.6_T2 3.475561e-03 -1.299780e-02 -2.469994e-03 -2.688441e-02
## PC.ae.C40.1_T2 -3.310003e-02 -3.688816e-03 -1.284723e-02 2.828099e-02
## PC.ae.C40.2_T2 -3.943195e-03 -1.661354e-02 -9.038716e-03 1.725591e-02
## PC.ae.C40.3_T2 -2.787244e-02 -2.010652e-02 -9.918548e-03 5.122218e-02
## PC.ae.C40.4_T2 -2.123979e-02 -5.679497e-03 -7.044808e-03 3.277380e-02
## PC.ae.C40.5_T2 -8.615418e-03 -8.009806e-03 -4.394572e-03 2.038005e-02
## PC.ae.C40.6_T2 1.394389e-02 -4.715064e-03 -8.658742e-03 -2.192161e-02
## PC.ae.C42.1_T2 -1.783160e-02 -5.196413e-03 -9.022386e-03 1.828677e-02
## PC.ae.C42.2_T2 -1.469556e-02 -6.237485e-03 -9.867524e-03 2.114717e-02
## PC.ae.C42.3_T2 -2.022567e-02 -7.640153e-03 -1.048333e-02 2.542849e-02
## PC.ae.C42.4_T2 -6.998390e-03 1.183103e-03 -6.298545e-03 1.679914e-02
## PC.ae.C42.5_T2 -3.959389e-03 3.885332e-03 -1.204315e-02 5.666786e-03
## PC.ae.C44.3_T2 4.091706e-02 8.664270e-02 -2.775953e-03 4.095166e-03
## PC.ae.C44.4_T2 -6.395072e-03 -1.056110e-03 -7.266386e-03 5.547778e-03
## PC.ae.C44.5_T2 -1.401818e-03 2.059569e-03 -2.124414e-02 -1.087812e-04
## PC.ae.C44.6_T2 5.904430e-04 5.268991e-03 -1.410377e-02 3.409129e-03
## SM..OH..C14.1_T2 3.366527e-02 -2.077587e-02 1.017706e-02 -1.840531e-02
## SM..OH..C16.1_T2 1.951528e-02 -9.783968e-03 6.572520e-03 -1.101476e-02
## SM..OH..C22.1_T2 1.884935e-02 -2.303099e-03 1.635293e-02 -2.690542e-02
## SM..OH..C22.2_T2 1.320650e-02 -3.092845e-02 1.368827e-02 2.916233e-03
## SM..OH..C24.1_T2 2.728188e-03 -4.509923e-04 -4.680979e-03 -2.906238e-03
## SM.C16.0_T2 6.615277e-02 -5.376878e-02 3.611990e-02 -2.929132e-02
## SM.C16.1_T2 8.904834e-02 -4.765072e-02 5.527723e-02 -3.073057e-02
## SM.C18.0_T2 9.910947e-02 -7.392411e-02 5.224966e-02 -4.347552e-02
## SM.C18.1_T2 7.748519e-02 -7.008898e-02 5.826868e-02 -4.969709e-02
## SM.C20.2_T2 1.846460e-03 -4.554238e-04 -3.021821e-03 -2.786772e-04
## SM.C24.0_T2 2.360632e-02 -1.531693e-02 6.666605e-04 -2.533367e-02
## SM.C24.1_T2 5.959837e-02 -6.845371e-02 -1.741256e-02 -4.567576e-02
## MEDDM_T4 -2.963370e-03 5.754962e-03 -3.768225e-03 -1.275726e-03
## MEDCOL_T4 -1.009762e-03 2.588154e-03 -1.444164e-02 -8.026152e-04
## MEDINF_T4 -1.252232e-03 -3.886012e-04 2.556351e-03 3.396193e-03
## MEDHTA_T4 -1.246162e-03 1.109517e-02 -1.726624e-02 -2.226849e-02
## GLU_T4 -3.561347e-02 -4.254452e-02 -7.877162e-02 -1.950549e-02
## INS_T4 -1.287056e-02 -3.939134e-02 1.306936e-01 6.291596e-02
## HOMA_T4 -1.179270e-02 -1.280699e-02 3.160142e-02 7.475613e-03
## HBA1C_T4 2.465549e-02 -2.781268e-02 -2.660195e-02 -2.773457e-03
## HBA1C.mmol.mol_T4 6.369202e-02 -7.490325e-02 -3.919187e-02 -1.313265e-02
## PESO_T4 -6.496623e-02 -7.592117e-03 1.591003e-02 4.639575e-02
## bmi_T4 -4.897977e-02 -2.726190e-02 4.791430e-02 1.541889e-02
## CC_T4 -4.464760e-03 2.957888e-03 -6.671185e-03 -7.523118e-03
## CINT_T4 -3.995109e-02 -2.975764e-02 -8.947627e-04 1.290638e-02
## CAD_T4 2.481504e-02 -5.354541e-02 6.695252e-03 6.343576e-02
## TAD_T4 4.548365e-02 1.214054e-02 -6.121800e-02 2.133890e-02
## TAS_T4 1.960126e-02 3.628588e-03 -3.699696e-02 -2.248791e-02
## TG_T4 -3.559311e-02 -1.529501e-02 -6.007111e-02 5.204960e-03
## COL_T4 -4.523528e-02 6.263504e-03 -1.076065e-02 4.672200e-02
## LDL_T4 -5.084284e-02 -6.422519e-03 -4.023937e-02 1.027389e-02
## HDL_T4 4.065310e-02 -2.642804e-02 5.991443e-02 2.338926e-02
## VLDL_T4 9.990379e-03 6.265937e-03 3.972424e-02 3.378397e-02
## PCR_T4 9.644593e-03 -2.159609e-02 -8.550667e-02 1.196478e-02
## LEP_T4 -3.669077e-02 -1.462298e-02 4.954674e-02 -1.047840e-02
## ADIPO_T4 -5.534688e-02 2.649450e-02 3.569385e-03 9.030047e-02
## GOT_T4 7.116236e-02 -3.123040e-02 1.673978e-01 -2.172159e-02
## GPT_T4 5.182040e-02 -5.091878e-03 1.104699e-01 -8.088319e-02
## GGT_T4 -9.891025e-02 2.055996e-02 -3.191489e-02 3.929081e-03
## URICO_T4 -4.705529e-02 -1.125586e-02 -1.456970e-02 -7.303651e-03
## CREAT_T4 -2.214782e-03 2.748368e-03 -1.199887e-02 2.998650e-03
## UREA_T4 3.108793e-03 4.932091e-03 -7.299718e-02 -2.505290e-02
## HIERRO_T4 -2.953150e-02 1.039663e-01 5.881875e-02 4.987392e-02
## TRANSF_T4 5.615200e-02 -8.735025e-03 -3.575571e-03 4.734691e-02
## FERR_T4 -1.887409e-01 7.540082e-02 6.221148e-02 -1.050779e-01
## Ile_T4 5.176401e-02 4.142027e-03 -4.056747e-03 1.153198e-02
## Leu_T4 4.850454e-02 -1.203267e-02 6.065030e-04 -2.050638e-04
## Val_T4 2.177057e-02 -5.302552e-02 -2.718385e-03 -5.083716e-02
## Ala_T4 5.110747e-02 1.770078e-02 2.922883e-02 3.156298e-03
## Pro_T4 -8.904453e-03 5.014361e-02 2.802227e-02 -9.338261e-02
## Gly_T4 1.891929e-02 -1.661869e-02 -8.955855e-02 2.853030e-02
## Ser_T4 -5.898379e-02 -5.989303e-02 1.839494e-01 -3.918096e-02
## Trp_T4 3.138003e-02 -7.409548e-02 -6.901881e-03 -2.668616e-02
## Phe_T4 6.850176e-02 -4.890943e-02 2.520552e-02 2.484411e-02
## Met_T4 -4.291478e-02 5.605554e-02 4.660805e-02 1.042586e-01
## Orn_T4 -1.324555e-02 5.547998e-03 1.974369e-02 -5.195545e-02
## Arg_T4 7.489732e-02 2.431003e-02 9.469686e-03 -2.534225e-02
## His_T4 4.326684e-02 4.416760e-02 -3.342290e-02 7.068245e-03
## Asn_T4 5.354641e-02 3.397750e-02 -1.258241e-02 4.207726e-02
## Asp_T4 8.256375e-03 -4.735445e-02 1.332316e-01 -5.408302e-03
## Glu_T4 2.400231e-02 -3.405638e-02 -2.262181e-02 -3.767125e-02
## Gln_T4 -6.194906e-02 -1.239127e-03 7.700237e-02 1.186514e-01
## Cit_T4 3.202020e-02 3.148642e-02 -3.302790e-02 3.749636e-02
## Tyr_T4 2.991269e-02 -1.353366e-02 5.505923e-02 -1.711026e-02
## Thr_T4 9.671230e-02 2.838351e-02 1.828151e-02 -4.089753e-03
## Lys_T4 7.334530e-02 -1.128077e-02 -2.640214e-02 8.137383e-02
## Creatinine_T4 5.132582e-02 1.243044e-02 -5.617787e-02 1.669197e-02
## Kynurenine_T4 -2.730343e-02 -1.847466e-02 -1.227162e-02 3.583644e-02
## Putrescine_T4 -5.446253e-04 -2.158068e-02 -4.729452e-02 -8.298705e-03
## Sarcosine_T4 3.734667e-02 -1.406874e-02 -1.710724e-02 1.081941e-01
## Serotonin_T4 4.575838e-02 1.963682e-01 6.932396e-02 -1.511642e-01
## Taurine_T4 -7.228980e-02 -1.418049e-01 3.191974e-02 4.162199e-02
## SDMA_T4 4.079096e-03 4.797180e-03 -1.344244e-02 -2.782485e-03
## C0_T4 -3.584924e-02 -1.590551e-02 4.073423e-02 -3.093013e-02
## C2_T4 -2.084882e-02 1.958785e-02 -1.944354e-03 -2.148055e-03
## C3.OH_T4 2.515937e-03 -1.584006e-03 -5.311720e-03 -3.434000e-03
## C6..C4.1.DC._T4 3.956603e-02 -2.091188e-02 2.262537e-02 4.061761e-02
## C5.DC..C6.OH._T4 -3.857755e-02 -3.629710e-02 3.755755e-02 -2.622176e-02
## C7.DC_T4 -4.347495e-02 -3.995431e-02 8.455304e-02 -6.109431e-02
## C8_T4 9.500520e-04 -5.612604e-04 -2.319623e-04 -4.295046e-03
## C10_T4 5.807210e-04 -9.306810e-05 1.931915e-04 -4.093998e-03
## C10.1_T4 -3.460423e-04 5.876391e-04 -4.592493e-03 -3.370593e-03
## C10.2_T4 4.937268e-05 1.593245e-04 -4.293878e-03 -1.162801e-03
## C14.1_T4 5.649514e-04 8.169459e-04 -3.380149e-03 -4.605279e-04
## C14.2_T4 -1.232382e-04 1.285401e-03 -3.965783e-03 -1.886381e-03
## C16.1_T4 -3.550093e-02 -1.538306e-02 1.275756e-03 -7.087088e-02
## C16.2_T4 -5.430206e-04 1.021309e-03 -4.246364e-03 -1.186287e-03
## C16.2.OH_T4 -3.511668e-02 -1.516488e-02 6.848548e-04 -7.107119e-02
## C18.1_T4 -4.058621e-04 7.239718e-04 -5.762999e-03 -5.359580e-04
## C18.1.OH_T4 -2.162845e-04 7.563391e-04 -4.836495e-03 -1.689858e-03
## C18.2_T4 -9.969098e-04 1.040148e-03 -5.207111e-03 -1.184258e-03
## lysoPC.a.C16.0_T4 -1.500528e-02 3.028293e-02 -5.261373e-02 -4.445840e-02
## lysoPC.a.C16.1_T4 -1.475630e-02 2.088092e-02 -4.753900e-02 2.191916e-02
## lysoPC.a.C17.0_T4 -2.977030e-03 1.028008e-03 -2.588104e-02 -3.425948e-02
## lysoPC.a.C18.0_T4 -6.292688e-02 -1.917215e-03 -5.118291e-02 -4.780054e-02
## lysoPC.a.C18.1_T4 -3.635266e-02 -3.618606e-04 -5.697115e-02 1.110732e-02
## lysoPC.a.C18.2_T4 -4.698036e-02 2.808918e-02 4.498640e-03 9.141209e-03
## lysoPC.a.C20.3_T4 -4.552917e-04 -1.630779e-03 -2.200788e-02 1.611703e-02
## lysoPC.a.C20.4_T4 4.203631e-03 7.370996e-02 -8.276289e-02 -3.052636e-02
## lysoPC.a.C24.0_T4 3.688759e-03 -4.718529e-03 -6.763800e-03 -3.847699e-03
## lysoPC.a.C26.0_T4 3.456902e-02 -6.212138e-02 2.127690e-03 1.204251e-02
## lysoPC.a.C26.1_T4 2.799536e-03 -8.775036e-04 -4.431155e-03 -3.180345e-03
## lysoPC.a.C28.0_T4 4.113247e-02 1.343145e-02 -3.980310e-02 -1.828396e-02
## lysoPC.a.C28.1_T4 5.416476e-03 -4.116920e-03 -6.312627e-03 -7.219282e-03
## PC.aa.C24.0_T4 -1.454696e-02 6.389067e-03 -1.436802e-02 4.787197e-02
## PC.aa.C28.1_T4 7.332123e-04 -1.184850e-02 2.099866e-02 3.998909e-03
## PC.aa.C30.0_T4 1.937616e-02 2.044104e-03 1.423889e-02 1.123421e-02
## PC.aa.C32.0_T4 1.935176e-02 2.357976e-02 -1.800722e-04 -7.264520e-03
## PC.aa.C32.1_T4 1.027950e-02 4.242482e-02 -7.140470e-03 4.521253e-02
## PC.aa.C32.3_T4 -9.141163e-04 2.032059e-03 -3.874716e-03 -6.955930e-04
## PC.aa.C34.1_T4 -9.043615e-03 3.190697e-03 -1.051438e-02 4.597056e-02
## PC.aa.C34.2_T4 -1.821035e-02 2.047105e-02 3.310523e-02 1.933254e-02
## PC.aa.C34.3_T4 -2.571070e-02 1.975993e-02 1.974746e-02 4.901624e-02
## PC.aa.C34.4_T4 1.631276e-03 5.272035e-03 -4.611263e-03 -9.621557e-04
## PC.aa.C36.0_T4 3.762923e-03 -4.420274e-03 -3.055163e-03 -2.052492e-02
## PC.aa.C36.1_T4 -3.873746e-02 4.221674e-03 4.388857e-02 1.122760e-01
## PC.aa.C36.2_T4 -5.894697e-02 -1.271242e-02 5.760406e-02 6.790256e-02
## PC.aa.C36.3_T4 1.661220e-03 5.393592e-03 1.338428e-02 9.357018e-02
## PC.aa.C36.4_T4 1.012471e-02 5.598967e-02 -3.305237e-02 -2.349966e-02
## PC.aa.C36.5_T4 6.227664e-04 -5.172429e-02 -3.017690e-03 -5.291586e-02
## PC.aa.C38.0_T4 -4.218488e-03 -2.767010e-02 1.846627e-03 -2.909064e-02
## PC.aa.C38.1_T4 1.091106e-02 -1.255861e-02 -2.032183e-03 -1.966418e-02
## PC.aa.C38.3_T4 -1.652286e-04 -1.795751e-02 -2.188948e-03 1.172520e-01
## PC.aa.C38.4_T4 -9.924405e-03 5.361878e-02 -3.975321e-02 -7.164609e-03
## PC.aa.C38.5_T4 3.813333e-03 3.360340e-02 -4.083679e-02 2.582135e-03
## PC.aa.C38.6_T4 -1.070665e-02 -2.748657e-02 3.807845e-02 -1.026598e-02
## PC.aa.C40.1_T4 -2.758569e-02 -1.816828e-02 2.841681e-03 3.397345e-02
## PC.aa.C40.2_T4 1.151710e-02 -6.580791e-03 -1.300279e-02 -1.767198e-02
## PC.aa.C40.3_T4 7.399126e-03 -7.016055e-03 -1.321395e-02 -1.425730e-02
## PC.aa.C40.4_T4 9.659133e-03 2.226419e-02 -2.455291e-02 3.192652e-03
## PC.aa.C40.5_T4 -1.420854e-02 2.446304e-02 -4.423761e-02 2.330266e-02
## PC.aa.C40.6_T4 -5.740346e-02 -4.675677e-02 2.867114e-02 1.172806e-02
## PC.aa.C42.0_T4 3.211356e-03 -4.088026e-03 -9.353651e-03 -7.517196e-03
## PC.aa.C42.1_T4 2.742538e-03 -2.035903e-03 -8.902093e-03 -8.707637e-03
## PC.aa.C42.2_T4 6.576323e-04 -2.606677e-03 -6.697159e-03 -5.433644e-03
## PC.aa.C42.4_T4 2.398073e-03 7.624295e-04 -8.742372e-03 -6.170174e-03
## PC.aa.C42.5_T4 1.559011e-03 9.681936e-04 -7.667086e-03 -4.869320e-03
## PC.aa.C42.6_T4 -5.025214e-02 2.408472e-02 -2.273495e-02 -8.674651e-04
## PC.ae.C30.0_T4 4.140842e-02 -4.154219e-02 -8.115773e-03 6.065665e-03
## PC.ae.C32.1_T4 8.613174e-03 1.223357e-02 -1.033448e-02 -6.536506e-04
## PC.ae.C32.2_T4 1.323237e-03 -9.585992e-04 -6.492289e-03 -5.849582e-03
## PC.ae.C34.0_T4 4.596985e-03 1.299996e-03 -4.108269e-03 -2.255847e-03
## PC.ae.C34.1_T4 1.752782e-02 5.648758e-03 -3.656550e-03 2.189463e-02
## PC.ae.C34.2_T4 8.172422e-03 9.429071e-03 1.327800e-02 -7.563946e-03
## PC.ae.C34.3_T4 -3.799324e-03 1.109603e-02 5.787021e-03 -2.800531e-02
## PC.ae.C36.0_T4 4.971041e-04 -1.900905e-03 -6.262126e-03 -7.064893e-03
## PC.ae.C36.1_T4 1.747832e-03 -7.143418e-03 4.010631e-03 7.404392e-03
## PC.ae.C36.2_T4 2.114275e-02 -1.774703e-02 3.098957e-02 -1.892833e-03
## PC.ae.C36.3_T4 -5.987296e-03 -3.020419e-03 5.717328e-03 4.800440e-03
## PC.ae.C36.4_T4 1.217160e-02 6.035299e-02 -1.276623e-02 -8.089785e-03
## PC.ae.C36.5_T4 1.908077e-03 5.015545e-02 -3.337034e-02 -4.710168e-02
## PC.ae.C38.0_T4 -8.790066e-03 -6.080608e-03 1.918166e-03 -4.500598e-03
## PC.ae.C38.2_T4 1.260397e-02 -3.357180e-02 -5.125020e-03 -3.154795e-02
## PC.ae.C38.3_T4 4.180329e-02 -2.449110e-02 -2.180616e-02 -4.038967e-02
## PC.ae.C38.4_T4 3.907820e-02 3.292004e-02 -1.712313e-02 -9.444771e-03
## PC.ae.C38.5_T4 2.307605e-02 5.220559e-02 -3.252722e-02 1.712560e-02
## PC.ae.C38.6_T4 2.168232e-03 8.302269e-03 -1.367573e-02 -8.646555e-03
## PC.ae.C40.1_T4 2.330914e-03 -8.867139e-03 -7.667027e-03 -2.043705e-02
## PC.ae.C40.2_T4 2.174075e-02 -2.686093e-02 -1.267464e-02 -2.265496e-02
## PC.ae.C40.3_T4 3.304654e-02 -2.807556e-02 -1.766457e-02 -4.773803e-02
## PC.ae.C40.4_T4 2.864004e-02 -2.423660e-04 -1.650785e-02 -3.204556e-02
## PC.ae.C40.5_T4 1.659836e-02 4.029261e-03 -1.338881e-02 -4.077159e-03
## PC.ae.C40.6_T4 5.776207e-03 -7.089510e-03 -2.360621e-03 -8.062906e-03
## PC.ae.C42.1_T4 6.148986e-03 -2.878741e-03 -1.275110e-02 -1.428392e-02
## PC.ae.C42.2_T4 4.732492e-03 -6.458944e-03 -1.128253e-02 -1.062454e-02
## PC.ae.C42.3_T4 -1.752186e-04 -1.035665e-02 -6.158558e-03 -4.124481e-03
## PC.ae.C42.4_T4 9.254661e-03 -4.073508e-03 -7.860874e-03 -2.467861e-03
## PC.ae.C42.5_T4 1.200472e-02 1.086484e-02 -2.195848e-02 2.353944e-04
## PC.ae.C44.3_T4 3.781439e-04 -1.050858e-03 -6.770637e-03 -1.058234e-03
## PC.ae.C44.4_T4 1.392722e-03 -1.333537e-03 -8.575811e-03 -1.468193e-03
## PC.ae.C44.5_T4 1.470236e-02 -3.289855e-03 -2.837573e-02 9.999868e-03
## PC.ae.C44.6_T4 5.865092e-03 4.838563e-03 -2.019941e-02 -4.824050e-03
## SM..OH..C14.1_T4 -8.085517e-04 -1.394831e-02 5.109055e-03 -7.773918e-03
## SM..OH..C16.1_T4 5.112711e-03 -1.177992e-02 5.538557e-03 5.817460e-04
## SM..OH..C22.1_T4 1.271011e-02 -3.368750e-03 1.451929e-02 2.676360e-02
## SM..OH..C22.2_T4 2.664727e-02 -3.945542e-02 3.105138e-03 1.714058e-02
## SM..OH..C24.1_T4 3.607805e-04 -8.097127e-04 -2.837958e-03 -1.467274e-03
## SM.C16.0_T4 -2.865638e-03 -1.003923e-02 1.826795e-02 3.383555e-02
## SM.C16.1_T4 -2.556143e-02 -2.491917e-02 5.221987e-02 2.914989e-02
## SM.C18.0_T4 7.557248e-03 -2.816922e-02 7.063108e-02 7.668434e-02
## SM.C18.1_T4 -1.110620e-02 -3.020417e-02 6.108626e-02 4.501951e-02
## SM.C20.2_T4 1.445860e-03 -3.337010e-04 -3.335444e-03 1.377575e-03
## SM.C24.0_T4 -8.474767e-03 8.847687e-03 -3.645598e-03 2.930436e-02
## SM.C24.1_T4 1.174740e-02 -7.009045e-02 3.905329e-03 6.463422e-02
## MEDDM_T5 -1.082724e-02 2.716964e-03 -2.887446e-02 -1.550444e-02
## MEDCOL_T5 -1.082724e-02 2.716964e-03 -2.887446e-02 -1.550444e-02
## MEDINF_T5 -1.407457e-02 6.078103e-04 -2.135812e-02 -8.639601e-03
## MEDHTA_T5 -1.320338e-02 7.551553e-03 -2.699927e-02 -1.526716e-02
## GLU_T5 1.593337e-02 2.258016e-02 -3.593125e-02 1.057958e-02
## INS_T5 3.637082e-02 9.222479e-03 3.109441e-02 6.327813e-03
## HOMA_T5 6.861174e-03 7.239727e-03 3.033774e-03 1.590169e-03
## HBA1C_T5 2.319046e-02 -1.649563e-02 -3.635850e-02 -1.165799e-04
## HBA1C.mmol.mol_T5 5.933693e-02 -3.686090e-02 -7.293033e-02 -4.188524e-03
## PESO_T5 2.526089e-02 2.618555e-02 3.738233e-02 7.551976e-02
## bmi_T5 3.819461e-02 9.534181e-03 6.171513e-02 4.534238e-02
## CC_T5 4.077414e-04 -1.415735e-03 -8.727145e-03 -1.566226e-03
## CINT_T5 4.143594e-02 6.225134e-03 2.513947e-02 4.691841e-02
## CAD_T5 4.956387e-02 1.208554e-02 6.053630e-02 6.961486e-02
## TAD_T5 1.186149e-02 2.761942e-02 -4.430733e-02 -3.390019e-02
## TAS_T5 2.959896e-02 7.734190e-03 -3.419118e-03 -2.132550e-02
## TG_T5 -3.897188e-02 6.768212e-02 -1.218975e-02 6.267905e-02
## COL_T5 -3.126460e-03 3.558914e-02 -1.766657e-02 1.972132e-02
## LDL_T5 -2.169419e-02 1.792490e-02 -6.559580e-02 -2.143061e-02
## HDL_T5 8.426584e-02 7.329597e-04 8.533006e-02 2.839523e-02
## VLDL_T5 1.873769e-02 4.834002e-02 6.317885e-02 5.878735e-02
## PCR_T5 1.267620e-02 5.304451e-02 -8.897455e-02 4.649102e-02
## LEP_T5 8.288139e-03 3.294235e-02 2.645899e-02 -8.494065e-03
## ADIPO_T5 -3.023114e-02 3.668397e-02 3.546695e-02 5.171272e-02
## GOT_T5 9.033558e-02 2.507465e-03 1.145424e-01 2.548381e-02
## GPT_T5 8.450890e-02 3.256861e-02 7.842056e-02 -2.414958e-02
## GGT_T5 -3.557564e-03 -4.734071e-02 -2.406235e-02 -6.231113e-03
## URICO_T5 1.325283e-02 -6.624057e-03 -9.136216e-03 1.078658e-02
## CREAT_T5 -3.217406e-03 4.430666e-03 -5.994361e-03 5.725033e-03
## UREA_T5 -4.296566e-02 -3.504833e-02 -1.203151e-01 5.452864e-02
## HIERRO_T5 -3.355250e-02 -3.013288e-02 -2.156559e-02 1.207686e-02
## TRANSF_T5 1.173092e-01 2.820142e-02 1.784916e-03 4.299777e-02
## FERR_T5 -1.512618e-01 1.037964e-01 3.275237e-03 -7.730720e-02
## Ile_T5 7.887115e-02 -7.188085e-03 -4.881575e-02 -2.637823e-02
## Leu_T5 4.055398e-02 -4.825904e-02 -7.521742e-02 3.208108e-02
## Val_T5 6.714787e-02 -7.414388e-02 -1.102458e-01 -1.371006e-02
## Ala_T5 5.677335e-02 9.678885e-03 -8.571009e-03 -1.502031e-02
## Pro_T5 5.340331e-02 2.666044e-02 -2.320341e-02 -2.971552e-02
## Gly_T5 -2.418874e-02 -1.019911e-01 -1.422973e-01 1.431207e-02
## Ser_T5 1.077362e-02 -3.863298e-02 -1.711425e-03 2.443934e-03
## Trp_T5 1.174078e-01 -8.825179e-03 -9.313282e-02 3.170049e-03
## Phe_T5 6.474094e-02 -5.999250e-02 -5.553184e-02 7.561041e-02
## Met_T5 8.154424e-02 1.376329e-02 -2.348760e-02 -2.496780e-02
## Orn_T5 -1.739963e-02 -2.805629e-02 -1.105739e-02 1.340920e-02
## Arg_T5 6.173632e-02 1.894404e-03 -4.257213e-02 -6.530664e-02
## His_T5 9.532990e-03 -9.889437e-03 -5.150260e-02 3.613048e-03
## Asn_T5 5.381699e-02 -4.945631e-03 -3.371726e-02 1.037367e-03
## Asp_T5 7.164767e-02 1.250238e-01 -4.212546e-03 4.898193e-02
## Glu_T5 6.077581e-02 -3.668342e-02 -3.113666e-02 -6.761728e-02
## Gln_T5 -4.387029e-02 4.596215e-03 -4.824594e-02 2.967048e-02
## Cit_T5 5.608761e-02 3.589517e-02 -1.344817e-02 -3.186934e-02
## Tyr_T5 5.687923e-02 -2.059850e-02 -3.692183e-02 2.290953e-02
## Thr_T5 1.208512e-01 1.644566e-02 -6.631512e-02 3.781645e-03
## Lys_T5 4.163185e-02 -2.538073e-02 4.232822e-03 -4.219093e-02
## Creatinine_T5 3.067504e-02 3.700952e-02 -5.904528e-03 4.219677e-02
## Kynurenine_T5 1.034619e-01 8.805927e-02 -2.010897e-02 -6.162148e-02
## Putrescine_T5 -3.480266e-02 -2.556432e-03 -7.791559e-02 -1.057361e-02
## Sarcosine_T5 4.591262e-02 2.481420e-02 1.040022e-02 1.284915e-01
## Serotonin_T5 5.492071e-02 1.754091e-01 9.444887e-02 -1.560732e-01
## Taurine_T5 -2.109221e-02 -8.867027e-02 -7.574716e-02 3.185287e-02
## SDMA_T5 4.952849e-03 -3.750518e-03 -8.369683e-03 2.875524e-05
## C0_T5 7.074340e-02 -4.407271e-02 3.072072e-03 -1.078739e-01
## C2_T5 -1.336890e-02 -4.103824e-02 -2.415932e-03 1.360997e-02
## C3.OH_T5 2.755685e-04 9.650116e-04 -8.839217e-03 1.276385e-04
## C6..C4.1.DC._T5 6.978304e-02 1.046737e-02 3.565767e-02 8.782238e-02
## C5.DC..C6.OH._T5 2.734851e-02 8.913988e-02 4.393648e-02 -7.964627e-02
## C7.DC_T5 -2.247382e-02 -2.080318e-02 5.477337e-02 3.375473e-02
## C8_T5 1.309397e-03 1.972525e-03 -8.888040e-03 9.240959e-04
## C10_T5 3.293169e-03 3.495705e-03 -6.233288e-03 2.230721e-03
## C10.1_T5 3.498937e-02 4.393752e-02 1.593568e-02 -2.358467e-02
## C10.2_T5 -2.137309e-04 8.530129e-04 -6.362194e-03 9.046966e-05
## C14.1_T5 -2.524459e-04 5.534664e-05 -7.005526e-03 3.814462e-04
## C14.2_T5 -4.054586e-04 9.410324e-04 -6.485425e-03 -3.964931e-04
## C16.1_T5 -3.081682e-04 1.504487e-03 -5.729879e-03 7.205978e-05
## C16.2_T5 -4.174391e-04 1.172119e-03 -5.690396e-03 -1.028407e-03
## C16.2.OH_T5 1.487932e-02 -1.971082e-02 -4.787517e-02 3.576454e-02
## C18.1_T5 -5.733491e-04 -4.275764e-04 -6.244103e-03 -1.226126e-03
## C18.1.OH_T5 -3.877681e-04 1.214227e-03 -5.872578e-03 -1.061695e-03
## C18.2_T5 -4.642825e-04 1.582082e-03 -5.346257e-03 -8.980237e-04
## lysoPC.a.C16.0_T5 -5.471362e-02 1.645155e-02 -2.053319e-02 -1.382439e-02
## lysoPC.a.C16.1_T5 -6.792216e-02 2.515535e-03 -2.330933e-02 3.142821e-02
## lysoPC.a.C17.0_T5 -1.856638e-02 5.256809e-03 -3.140394e-02 -1.866769e-02
## lysoPC.a.C18.0_T5 -5.296130e-02 -1.483974e-02 -3.396037e-02 -4.106450e-02
## lysoPC.a.C18.1_T5 -5.255595e-02 -2.239905e-02 -1.627358e-02 -3.640602e-02
## lysoPC.a.C18.2_T5 -3.282580e-02 2.122661e-02 -3.527273e-02 -7.182280e-02
## lysoPC.a.C20.3_T5 -2.113241e-02 -9.989028e-03 -2.393847e-02 -4.138575e-02
## lysoPC.a.C20.4_T5 -4.684367e-02 2.087319e-02 -2.536830e-02 -1.120820e-01
## lysoPC.a.C24.0_T5 -1.097509e-03 3.242205e-03 -8.497102e-03 -9.847666e-04
## lysoPC.a.C26.0_T5 -1.830063e-03 6.116493e-03 -4.985887e-03 -2.699504e-04
## lysoPC.a.C26.1_T5 -1.909900e-03 5.266169e-03 -7.372260e-03 -4.421433e-03
## lysoPC.a.C28.0_T5 -5.166134e-02 4.255938e-03 7.223814e-02 -8.609684e-02
## lysoPC.a.C28.1_T5 -2.527876e-03 4.516208e-03 -3.164599e-03 -2.336600e-03
## PC.aa.C24.0_T5 -1.974045e-02 1.314509e-01 3.624454e-02 -4.787912e-02
## PC.aa.C28.1_T5 1.922035e-03 -1.973625e-03 1.443536e-04 2.437260e-02
## PC.aa.C30.0_T5 1.448301e-02 1.475720e-02 9.323869e-03 1.830472e-02
## PC.aa.C32.0_T5 -3.312024e-02 -1.496585e-03 2.280646e-02 3.102177e-02
## PC.aa.C32.1_T5 -5.405710e-02 3.182436e-02 4.903303e-02 9.931536e-02
## PC.aa.C32.3_T5 -7.091728e-04 1.092055e-03 -5.295728e-03 -7.835971e-04
## PC.aa.C34.1_T5 -4.599543e-02 -4.230836e-03 3.813402e-02 5.768874e-02
## PC.aa.C34.2_T5 -3.899521e-03 2.922977e-02 3.090340e-02 3.576069e-02
## PC.aa.C34.3_T5 2.622451e-03 4.670333e-02 2.049960e-02 6.111297e-02
## PC.aa.C34.4_T5 4.354316e-03 4.119463e-03 -4.112614e-03 1.295607e-05
## PC.aa.C36.0_T5 -5.894989e-04 6.127455e-03 3.811406e-03 2.316950e-03
## PC.aa.C36.1_T5 -1.901234e-02 -2.694626e-02 6.598997e-02 2.916175e-02
## PC.aa.C36.2_T5 -7.120586e-03 -7.879003e-03 3.244387e-02 1.532605e-02
## PC.aa.C36.3_T5 5.902780e-03 6.395788e-03 1.913230e-02 3.694396e-02
## PC.aa.C36.4_T5 -2.225722e-02 3.084513e-02 3.031005e-02 -2.073018e-02
## PC.aa.C36.5_T5 6.062396e-02 -3.148680e-02 2.398368e-02 -2.264831e-02
## PC.aa.C38.0_T5 -1.509765e-02 -3.907219e-02 1.629524e-03 1.254236e-03
## PC.aa.C38.1_T5 -5.814336e-03 -7.794358e-04 -1.614005e-03 1.175180e-03
## PC.aa.C38.3_T5 9.565654e-03 -3.195084e-02 1.359375e-02 3.228411e-02
## PC.aa.C38.4_T5 -3.991045e-02 -1.812893e-02 -9.072570e-03 -4.697243e-02
## PC.aa.C38.5_T5 -4.079310e-02 -5.723186e-04 1.255423e-02 -3.181502e-02
## PC.aa.C38.6_T5 -1.792001e-02 -3.169056e-02 1.599709e-02 -5.276672e-04
## PC.aa.C40.1_T5 -3.338536e-02 -1.984812e-02 7.715903e-02 -3.863455e-02
## PC.aa.C40.2_T5 -3.909371e-03 7.432887e-04 -4.173958e-03 4.653526e-03
## PC.aa.C40.3_T5 -9.260919e-03 2.508676e-03 -2.902500e-03 1.019346e-02
## PC.aa.C40.4_T5 -1.606629e-02 1.227898e-02 -2.026298e-03 3.595386e-03
## PC.aa.C40.5_T5 -4.020912e-02 6.639409e-03 -4.564533e-03 -1.816658e-02
## PC.aa.C40.6_T5 -2.679179e-02 -6.181423e-02 -1.399013e-02 -1.465100e-02
## PC.aa.C42.0_T5 -1.403202e-03 -2.868960e-03 -6.368567e-03 2.749895e-03
## PC.aa.C42.1_T5 -2.935291e-03 -7.127344e-04 -6.050230e-03 1.739649e-03
## PC.aa.C42.2_T5 -3.976534e-03 5.075848e-04 -4.333639e-03 3.846843e-03
## PC.aa.C42.4_T5 -3.377493e-03 1.240568e-03 -5.268685e-03 1.204601e-03
## PC.aa.C42.5_T5 -3.364013e-03 1.017347e-03 -4.890348e-03 2.318342e-03
## PC.aa.C42.6_T5 4.159511e-02 8.156988e-02 -6.555945e-03 -3.000682e-02
## PC.ae.C30.0_T5 4.972991e-02 9.226792e-02 -3.498840e-03 1.417795e-03
## PC.ae.C32.1_T5 2.410719e-03 -7.045593e-03 -9.124176e-03 8.737994e-03
## PC.ae.C32.2_T5 -3.108654e-03 -3.023928e-03 -6.308563e-03 1.786993e-03
## PC.ae.C34.0_T5 1.212609e-03 1.508917e-04 -4.971144e-03 3.762786e-04
## PC.ae.C34.1_T5 -7.530571e-03 -5.118293e-03 -9.498190e-03 4.296218e-02
## PC.ae.C34.2_T5 1.636470e-02 -1.503742e-02 3.645595e-03 1.151942e-03
## PC.ae.C34.3_T5 2.339873e-02 -9.549721e-03 1.337139e-02 -1.446075e-02
## PC.ae.C36.0_T5 -1.170980e-03 -1.973370e-03 -2.125910e-03 1.020281e-03
## PC.ae.C36.1_T5 -1.336667e-02 1.060894e-02 8.798051e-03 2.418592e-02
## PC.ae.C36.2_T5 -1.907588e-02 1.858680e-02 1.243998e-02 2.333826e-02
## PC.ae.C36.3_T5 8.008667e-03 -7.199332e-03 -3.255585e-04 8.810628e-03
## PC.ae.C36.4_T5 6.406507e-03 1.208116e-02 2.278356e-02 -3.373778e-02
## PC.ae.C36.5_T5 -1.030469e-02 4.912747e-03 -1.540687e-03 -5.463286e-02
## PC.ae.C38.0_T5 -7.587657e-04 -5.709134e-03 -7.422416e-03 -1.040486e-03
## PC.ae.C38.2_T5 -2.099311e-02 -5.637477e-04 -7.078014e-03 2.771965e-02
## PC.ae.C38.3_T5 3.143354e-02 -1.686693e-02 -1.134667e-02 -3.742623e-02
## PC.ae.C38.4_T5 5.370301e-03 2.249926e-02 -1.026004e-02 -5.107049e-03
## PC.ae.C38.5_T5 -1.422989e-04 -2.420935e-02 8.095097e-03 -1.715914e-02
## PC.ae.C38.6_T5 -6.802001e-03 -2.724048e-02 1.359874e-04 -1.948833e-02
## PC.ae.C40.1_T5 -6.598398e-03 6.138561e-03 -1.194759e-04 -7.372958e-03
## PC.ae.C40.2_T5 1.972888e-03 -1.076203e-02 -9.200504e-03 -1.152093e-03
## PC.ae.C40.3_T5 2.569959e-02 -2.394463e-02 -1.524560e-02 -3.500761e-02
## PC.ae.C40.4_T5 6.658703e-03 -4.151128e-03 -9.376796e-03 -7.457102e-03
## PC.ae.C40.5_T5 2.132805e-02 -1.140110e-02 -6.251833e-03 -2.610947e-02
## PC.ae.C40.6_T5 4.960592e-03 -7.936952e-03 -6.000405e-03 -6.772828e-03
## PC.ae.C42.1_T5 -2.438481e-03 8.003791e-04 -6.724632e-03 -2.484172e-03
## PC.ae.C42.2_T5 -2.041887e-03 -1.155705e-03 -7.414620e-03 3.828835e-03
## PC.ae.C42.3_T5 -4.452670e-03 -2.282944e-03 -7.194325e-03 7.546645e-03
## PC.ae.C42.4_T5 -1.365282e-03 2.624759e-03 -9.843153e-03 8.121802e-03
## PC.ae.C42.5_T5 1.239169e-02 -1.361381e-02 -2.078686e-02 -1.031392e-02
## PC.ae.C44.3_T5 -3.353828e-03 2.143957e-03 -4.924470e-03 1.627147e-03
## PC.ae.C44.4_T5 2.303713e-04 3.227515e-04 -5.864993e-03 6.018613e-03
## PC.ae.C44.5_T5 7.859187e-04 -7.644451e-03 -2.689118e-02 1.021455e-02
## PC.ae.C44.6_T5 -2.164362e-03 -2.675255e-03 -1.535366e-02 3.897754e-03
## SM..OH..C14.1_T5 -1.626661e-02 -5.471280e-03 -1.555359e-02 1.216396e-02
## SM..OH..C16.1_T5 -3.489231e-03 2.715945e-04 -2.363452e-03 -2.716691e-04
## SM..OH..C22.1_T5 2.977165e-02 2.589509e-02 8.844331e-03 2.166580e-02
## SM..OH..C22.2_T5 2.959706e-02 -1.511184e-02 1.097070e-03 2.479967e-02
## SM..OH..C24.1_T5 3.277646e-03 7.960143e-04 -5.219787e-03 1.034501e-04
## SM.C16.0_T5 -8.042288e-03 -6.162363e-03 -2.033084e-03 1.674143e-02
## SM.C16.1_T5 3.355513e-03 -4.088337e-03 3.831553e-02 4.858587e-02
## SM.C18.0_T5 -3.086206e-02 -1.593002e-02 5.534244e-02 4.877763e-02
## SM.C18.1_T5 -1.812959e-02 -4.730669e-02 4.855678e-02 3.976350e-02
## SM.C20.2_T5 -5.730904e-04 2.264618e-03 -4.415141e-03 1.282638e-03
## SM.C24.0_T5 2.202035e-02 5.786355e-02 1.051895e-02 3.888651e-02
## SM.C24.1_T5 -5.112339e-03 -1.654842e-02 1.111090e-03 1.824336e-02
## PC17 PC18 PC19 PC20
## GLU_T0 -5.490559e-02 -4.092355e-02 -2.700875e-02 -1.092410e-02
## INS_T0 2.152062e-02 -3.112322e-02 -7.659210e-02 5.312025e-02
## HOMA_T0 -5.838586e-03 -3.607597e-02 -5.470274e-02 2.363576e-02
## HBA1C_T0 4.507277e-03 7.368920e-03 1.416281e-03 1.651632e-02
## HBA1C.mmol.mol_T0 -2.925114e-03 4.367383e-03 -1.865977e-02 2.629169e-02
## PESO_T0 3.777103e-02 1.999627e-02 -3.415349e-02 2.010457e-03
## bmi_T0 5.810855e-02 3.762993e-03 -5.293962e-02 1.250522e-02
## CC_T0 -1.150354e-03 2.958652e-03 3.072767e-03 1.662323e-03
## CINT_T0 -5.708371e-03 4.021221e-02 5.715867e-04 -2.095159e-03
## CAD_T0 3.437720e-02 1.671407e-02 -4.252091e-03 1.787218e-02
## TAD_T0 4.804160e-02 -4.603080e-02 6.501406e-02 -1.300588e-02
## TAS_T0 9.848741e-02 4.699694e-03 -1.543890e-03 -2.030729e-02
## TG_T0 -3.521471e-02 7.168451e-02 1.574124e-02 -5.895809e-02
## COL_T0 5.081130e-03 -3.747983e-02 -3.208476e-02 -5.746933e-02
## LDL_T0 -2.144503e-02 -5.361011e-02 -1.844223e-02 -2.198473e-02
## HDL_T0 1.147506e-01 -5.890404e-02 -2.898241e-02 -8.397055e-02
## VLDL_T0 -3.565936e-02 7.232983e-02 1.637269e-02 -5.927650e-02
## PCR_T0 -5.844114e-02 -1.024094e-01 2.876870e-03 -3.309160e-02
## LEP_T0 7.243700e-02 -8.725377e-02 -1.250407e-01 -4.302222e-02
## ADIPO_T0 -4.398236e-02 2.860206e-02 2.417553e-02 -2.621730e-02
## GOT_T0 6.200685e-03 -1.111685e-01 8.660861e-02 -8.368214e-02
## GPT_T0 -1.251327e-01 -1.588052e-01 3.588752e-02 6.251228e-02
## GGT_T0 3.295591e-03 -6.950814e-02 2.312116e-03 -1.021958e-02
## URICO_T0 2.206526e-02 -2.993976e-03 -2.055602e-02 -8.002801e-03
## CREAT_T0 3.515568e-04 -1.780627e-03 9.066594e-03 1.376834e-04
## UREA_T0 1.804580e-02 -1.011850e-01 -8.791940e-02 4.307207e-02
## HIERRO_T0 -5.978473e-02 3.575671e-02 1.555624e-03 -8.945251e-02
## TRANSF_T0 1.506982e-02 -3.168481e-02 -8.212400e-03 -3.623487e-02
## FERR_T0 2.340281e-02 2.215590e-02 2.075967e-02 -2.552899e-02
## Ile_T0 -2.865453e-02 -1.453687e-01 2.189191e-02 2.393135e-02
## Leu_T0 -5.859747e-02 -1.497893e-01 1.095779e-02 -2.821243e-03
## Val_T0 -4.385671e-02 -9.245595e-02 -1.730010e-02 -2.040455e-03
## Ala_T0 -1.953238e-02 9.540596e-03 -4.031451e-02 -2.403085e-02
## Pro_T0 5.083875e-02 5.240022e-02 -9.887717e-03 -9.887871e-02
## Gly_T0 -3.676431e-02 8.702232e-02 1.044961e-01 9.478790e-02
## Ser_T0 4.072374e-02 -6.718970e-02 1.638522e-01 2.923717e-02
## Trp_T0 4.902278e-02 -4.258436e-02 6.106003e-02 8.666461e-03
## Phe_T0 -1.382246e-02 -8.006035e-02 -7.788665e-02 -6.834349e-03
## Met_T0 6.443877e-02 -3.289585e-02 -3.822541e-02 2.303215e-02
## Orn_T0 5.004120e-02 -1.537992e-01 2.315806e-02 -2.271006e-02
## Arg_T0 5.697562e-02 1.243153e-02 2.078512e-02 -5.648961e-03
## His_T0 -3.727264e-02 7.022382e-02 3.873787e-02 -2.472786e-02
## Asn_T0 -3.383845e-02 -4.219928e-02 6.834984e-02 -4.697194e-02
## Asp_T0 2.958171e-02 -1.054945e-02 3.272341e-02 -4.050921e-02
## Glu_T0 4.334157e-02 -1.386181e-02 2.155820e-02 7.586685e-03
## Gln_T0 -2.940615e-02 4.975070e-02 3.493979e-02 -1.976730e-02
## Cit_T0 -3.850184e-02 -8.457599e-03 -2.043511e-02 2.442743e-02
## Tyr_T0 2.759608e-02 -5.393141e-02 -3.682083e-02 -8.961691e-02
## Thr_T0 8.924578e-03 2.119175e-02 1.197457e-01 -7.346313e-02
## Lys_T0 2.562233e-02 -4.942886e-02 -5.091650e-03 4.401607e-02
## Creatinine_T0 -2.553138e-02 3.068423e-02 9.040506e-02 3.195362e-02
## Kynurenine_T0 -7.661044e-03 -9.114695e-03 -1.865947e-03 -1.147008e-02
## Putrescine_T0 -1.065581e-02 -2.456077e-03 -1.471124e-01 -2.754960e-02
## Sarcosine_T0 8.185517e-03 1.196955e-03 -9.202355e-03 -1.701965e-02
## Serotonin_T0 1.576485e-01 -2.065110e-02 -1.830018e-03 6.784788e-02
## Taurine_T0 3.203646e-02 -4.971706e-02 9.174274e-02 2.989000e-02
## SDMA_T0 -4.645847e-03 -3.213100e-03 8.343395e-03 5.236851e-03
## C0_T0 7.327077e-02 2.682715e-02 4.116881e-02 3.196716e-02
## C2_T0 -6.140331e-02 -1.108695e-01 1.142423e-01 1.639608e-01
## C3.OH_T0 -5.673324e-04 -1.639289e-03 5.337222e-03 1.520526e-03
## C6..C4.1.DC._T0 9.429948e-02 3.741788e-02 4.541936e-02 8.629913e-03
## C5.DC..C6.OH._T0 -3.075516e-02 -9.096595e-02 -1.385846e-01 -3.347217e-02
## C7.DC_T0 -5.254710e-02 -1.084659e-01 -6.569024e-02 5.978080e-02
## C8_T0 -2.357011e-03 -1.471525e-04 -2.899519e-04 -2.465910e-03
## C10_T0 1.682372e-04 -1.227066e-05 7.050194e-03 2.457647e-03
## C10.1_T0 -8.296375e-04 1.391292e-03 2.422097e-03 -3.764435e-04
## C10.2_T0 -4.132659e-04 6.273444e-04 4.136222e-03 8.660498e-04
## C14.1_T0 -2.702882e-04 -2.574005e-04 6.340751e-03 1.651799e-03
## C14.2_T0 -5.235453e-04 7.735441e-04 4.385455e-03 1.158334e-04
## C16.1_T0 -6.488350e-04 7.493572e-04 4.325097e-03 5.345033e-04
## C16.2_T0 -8.403745e-04 4.441637e-04 3.762748e-03 1.224126e-03
## C16.2.OH_T0 -9.070440e-04 4.199846e-04 3.055061e-03 1.448113e-03
## C18.1_T0 -1.148225e-03 -1.389285e-03 5.629066e-03 3.591435e-03
## C18.1.OH_T0 -9.234118e-04 2.672951e-04 3.648286e-03 7.110216e-04
## C18.2_T0 -9.846057e-04 1.299383e-03 4.224655e-03 1.619939e-03
## lysoPC.a.C16.0_T0 2.556280e-02 4.178108e-02 4.862934e-03 -3.086857e-02
## lysoPC.a.C16.1_T0 2.014913e-02 2.186324e-02 -1.372626e-02 -3.418675e-02
## lysoPC.a.C17.0_T0 7.783182e-03 1.614362e-02 -1.278502e-02 1.044028e-02
## lysoPC.a.C18.0_T0 1.542520e-02 6.500378e-02 -2.206736e-02 -1.473379e-02
## lysoPC.a.C18.1_T0 3.521016e-02 4.982641e-02 -1.942835e-02 -2.245310e-02
## lysoPC.a.C18.2_T0 6.329539e-02 1.096234e-01 -3.240428e-02 1.586087e-02
## lysoPC.a.C20.3_T0 7.304141e-03 5.034228e-02 -4.593012e-02 -1.618127e-02
## lysoPC.a.C20.4_T0 8.815317e-02 2.069575e-04 -5.929056e-02 -2.366674e-02
## lysoPC.a.C24.0_T0 -9.700802e-03 -2.515753e-04 6.442238e-03 -3.240191e-03
## lysoPC.a.C26.0_T0 -4.689553e-02 -4.899630e-02 -3.165835e-02 -3.326241e-02
## lysoPC.a.C26.1_T0 -2.677324e-03 -2.039666e-03 8.983271e-03 -4.889560e-04
## lysoPC.a.C28.0_T0 9.875283e-03 -7.104205e-02 -7.017408e-02 2.606919e-02
## lysoPC.a.C28.1_T0 -5.243889e-03 -2.717692e-03 5.266199e-03 1.870487e-03
## PC.aa.C24.0_T0 -7.941871e-03 -8.178057e-03 7.033402e-02 -6.905883e-02
## PC.aa.C28.1_T0 2.512899e-02 -9.880709e-03 1.873153e-02 -4.889612e-03
## PC.aa.C30.0_T0 1.721981e-02 -2.002867e-02 3.621551e-03 -3.439713e-02
## PC.aa.C32.0_T0 1.850971e-02 -4.740190e-02 3.483033e-02 -7.052074e-02
## PC.aa.C32.1_T0 3.907812e-02 3.132373e-03 -4.809612e-02 -9.936810e-02
## PC.aa.C32.3_T0 -5.184625e-04 1.085737e-03 3.190905e-03 -4.024116e-04
## PC.aa.C34.1_T0 -1.363685e-02 -3.028159e-02 -2.130208e-03 -1.680484e-02
## PC.aa.C34.2_T0 -3.320273e-03 3.713830e-02 -1.533421e-03 5.019943e-02
## PC.aa.C34.3_T0 2.317214e-02 8.875097e-02 -8.070000e-02 -3.359351e-02
## PC.aa.C34.4_T0 6.124671e-03 9.971465e-03 -1.868074e-02 -6.653369e-03
## PC.aa.C36.0_T0 -1.900783e-02 -2.767140e-03 2.527396e-03 -1.216610e-02
## PC.aa.C36.1_T0 1.534398e-03 3.569262e-02 -2.201023e-02 -4.302561e-02
## PC.aa.C36.2_T0 -1.390494e-02 4.634680e-02 -3.978655e-02 3.880724e-02
## PC.aa.C36.3_T0 -3.123463e-03 8.594698e-02 -4.409940e-02 1.856482e-02
## PC.aa.C36.4_T0 2.674258e-02 -6.466226e-03 -5.288930e-02 -4.058045e-04
## PC.aa.C36.5_T0 4.751567e-03 3.640604e-02 -5.697816e-02 -2.475218e-02
## PC.aa.C38.0_T0 -4.330025e-02 -1.812313e-02 7.844610e-03 -3.432196e-02
## PC.aa.C38.1_T0 -4.752403e-02 1.998789e-02 -8.566905e-03 -1.029621e-02
## PC.aa.C38.3_T0 -2.137518e-02 4.557289e-02 -6.459026e-02 -2.934414e-02
## PC.aa.C38.4_T0 2.779411e-02 -2.512343e-02 -6.799635e-02 -2.397106e-02
## PC.aa.C38.5_T0 7.165282e-02 2.167231e-02 -7.055039e-02 -3.329998e-02
## PC.aa.C38.6_T0 -1.089760e-01 -7.277295e-02 3.123919e-02 3.225996e-02
## PC.aa.C40.1_T0 -5.706020e-02 -9.645459e-02 -8.463728e-02 -6.083184e-02
## PC.aa.C40.2_T0 -1.710732e-02 9.889803e-03 2.285828e-02 -5.435965e-03
## PC.aa.C40.3_T0 -1.710833e-02 8.218577e-03 1.660331e-02 -7.656318e-03
## PC.aa.C40.4_T0 4.347806e-03 1.198486e-02 -6.272019e-03 -2.146941e-02
## PC.aa.C40.5_T0 9.927903e-03 -1.088410e-03 -5.284861e-02 -3.408879e-02
## PC.aa.C40.6_T0 -8.576444e-02 -7.974956e-02 -1.424585e-02 -3.170629e-02
## PC.aa.C42.0_T0 -3.252043e-03 -5.191612e-03 7.379707e-03 -1.437790e-02
## PC.aa.C42.1_T0 -4.188265e-03 -1.841826e-03 6.646036e-03 -5.765321e-03
## PC.aa.C42.2_T0 -8.124026e-03 4.533972e-03 8.917749e-03 -5.652817e-03
## PC.aa.C42.4_T0 -1.089395e-02 5.917717e-03 1.274648e-02 -3.840830e-03
## PC.aa.C42.5_T0 -9.068456e-03 2.469674e-03 7.481896e-03 -3.792296e-03
## PC.aa.C42.6_T0 -7.900507e-02 -4.354078e-02 -5.889573e-02 -1.643085e-02
## PC.ae.C30.0_T0 1.296718e-03 -1.583829e-03 3.771343e-03 -5.385731e-04
## PC.ae.C32.1_T0 9.087599e-03 -1.262309e-02 1.215224e-02 -1.656462e-02
## PC.ae.C32.2_T0 -6.082830e-04 -5.697287e-04 6.371665e-03 -3.986349e-03
## PC.ae.C34.0_T0 -1.439885e-03 -1.290965e-03 -5.602199e-04 -8.102079e-04
## PC.ae.C34.1_T0 8.660111e-03 -2.152220e-02 -8.517863e-04 -1.555633e-02
## PC.ae.C34.2_T0 -3.987401e-03 5.850034e-02 -7.183275e-02 5.369075e-03
## PC.ae.C34.3_T0 3.270389e-02 5.815911e-02 -8.012056e-03 5.204708e-03
## PC.ae.C36.0_T0 -8.505557e-03 -1.998137e-03 7.517168e-03 -4.731469e-03
## PC.ae.C36.1_T0 -2.543279e-02 1.143504e-02 2.383421e-02 -5.118934e-03
## PC.ae.C36.2_T0 -3.317209e-02 2.755614e-02 -1.645852e-02 3.154139e-02
## PC.ae.C36.3_T0 -1.022092e-02 3.885585e-02 -2.880692e-02 7.472467e-03
## PC.ae.C36.4_T0 2.426792e-02 -7.808073e-03 -7.944811e-02 -1.130506e-02
## PC.ae.C36.5_T0 2.510836e-02 4.868956e-03 -6.941803e-02 -2.607342e-02
## PC.ae.C38.0_T0 -1.584973e-02 6.806525e-03 -7.792178e-03 -6.403096e-03
## PC.ae.C38.2_T0 -5.016557e-02 2.832665e-02 3.698204e-02 -7.304292e-03
## PC.ae.C38.3_T0 2.355175e-02 9.053426e-03 2.041065e-02 1.272542e-02
## PC.ae.C38.4_T0 2.742137e-02 -2.199119e-02 -1.012060e-02 -1.183907e-03
## PC.ae.C38.5_T0 5.443913e-03 -2.157281e-02 -3.354511e-02 -3.664634e-03
## PC.ae.C38.6_T0 -6.755905e-03 -1.179576e-02 -4.846104e-02 -8.939368e-03
## PC.ae.C40.1_T0 -3.112303e-05 1.027990e-02 3.562830e-03 -1.729371e-02
## PC.ae.C40.2_T0 -2.764086e-02 1.129196e-02 3.144882e-02 6.466890e-03
## PC.ae.C40.3_T0 2.773855e-03 9.473914e-03 3.468408e-02 5.565826e-03
## PC.ae.C40.4_T0 7.771939e-03 7.038050e-04 2.626553e-02 -9.098433e-03
## PC.ae.C40.5_T0 -4.284959e-03 7.576031e-04 3.357796e-02 -1.500948e-03
## PC.ae.C40.6_T0 -1.219459e-02 -1.878090e-02 -2.897199e-03 -3.382792e-03
## PC.ae.C42.1_T0 -1.036169e-02 6.472336e-03 1.165624e-02 -4.964482e-03
## PC.ae.C42.2_T0 -8.377548e-03 7.293215e-03 1.168847e-02 -4.231508e-03
## PC.ae.C42.3_T0 -1.491342e-02 7.199068e-03 1.701073e-02 -6.867910e-03
## PC.ae.C42.4_T0 1.286503e-03 3.072302e-03 1.387848e-02 -1.257395e-02
## PC.ae.C42.5_T0 2.836173e-03 -1.582374e-02 2.359212e-02 -1.704043e-02
## PC.ae.C44.3_T0 -8.626726e-03 3.945037e-03 1.007617e-02 -2.418848e-03
## PC.ae.C44.4_T0 -1.995410e-03 1.134433e-03 4.567722e-03 -7.471991e-03
## PC.ae.C44.5_T0 1.701369e-02 -1.747354e-02 -3.501194e-03 -2.521859e-02
## PC.ae.C44.6_T0 8.644917e-03 -1.355020e-02 -9.016693e-04 -2.523803e-02
## SM..OH..C14.1_T0 -1.862868e-03 -6.541354e-03 4.368223e-03 2.973083e-02
## SM..OH..C16.1_T0 -8.638892e-03 -1.128518e-02 1.026700e-02 1.403261e-02
## SM..OH..C22.1_T0 -5.939349e-02 -3.541977e-02 -2.330311e-02 6.197891e-02
## SM..OH..C22.2_T0 -4.864624e-02 5.492834e-03 7.342730e-03 2.235689e-02
## SM..OH..C24.1_T0 -3.233136e-03 -1.623579e-03 3.172475e-03 7.312356e-03
## SM.C16.0_T0 -4.325044e-02 -6.421901e-02 8.763426e-02 1.641196e-02
## SM.C16.1_T0 -5.245865e-02 2.947474e-03 5.266606e-02 2.130010e-02
## SM.C18.0_T0 -6.308961e-02 -6.555852e-02 8.666762e-02 1.502255e-03
## SM.C18.1_T0 -5.418426e-02 -5.156286e-02 8.296813e-02 1.122693e-02
## SM.C20.2_T0 -2.023827e-03 -2.769167e-04 1.297574e-03 -7.727625e-04
## SM.C24.0_T0 -8.121286e-02 -3.239787e-02 1.824048e-02 2.058159e-02
## SM.C24.1_T0 -9.245548e-02 -5.964406e-02 6.424187e-02 1.212290e-02
## MEDDM_T2 -9.911653e-04 5.279635e-04 2.923889e-03 7.832266e-04
## MEDCOL_T2 -9.911653e-04 5.279635e-04 2.923889e-03 7.832266e-04
## MEDINF_T2 8.953846e-03 -1.650953e-03 6.330719e-03 -6.772204e-03
## MEDHTA_T2 2.593182e-02 -1.300926e-02 -4.772018e-03 4.026684e-03
## GLU_T2 1.648931e-02 -8.477003e-04 1.950746e-02 -3.770850e-03
## INS_T2 4.675348e-02 5.321836e-02 1.196790e-01 3.509012e-02
## HOMA_T2 2.344932e-02 2.522946e-02 7.343362e-02 1.442762e-02
## HBA1C_T2 1.941188e-02 1.798991e-02 1.225033e-02 7.925426e-03
## HBA1C.mmol.mol_T2 5.513343e-02 4.828663e-02 1.865908e-02 2.933667e-03
## PESO_T2 -1.862619e-02 6.391804e-02 -3.853431e-02 3.139737e-02
## bmi_T2 -1.355935e-03 4.972415e-02 -6.195746e-02 5.127104e-02
## CC_T2 -2.024593e-03 3.978531e-03 8.788991e-03 -2.754333e-04
## CINT_T2 -1.314651e-02 4.106960e-02 6.710103e-03 -1.144727e-03
## CAD_T2 2.637435e-02 2.665748e-02 -3.393187e-02 4.110680e-02
## TAD_T2 4.412112e-02 -5.541372e-02 7.881840e-02 6.562472e-02
## TAS_T2 1.865424e-02 -1.142595e-02 5.868610e-02 3.010707e-02
## TG_T2 -1.153820e-02 -8.979319e-03 2.028678e-02 -4.262034e-02
## COL_T2 -7.118528e-02 -5.750565e-02 1.910225e-02 -7.010333e-03
## LDL_T2 -4.042741e-02 -8.438368e-02 4.707772e-02 4.861225e-02
## HDL_T2 6.122039e-02 -5.605841e-02 -6.546252e-02 -6.684238e-02
## VLDL_T2 2.580204e-02 -5.590872e-02 1.035389e-02 -6.321582e-02
## PCR_T2 -1.392201e-02 -1.752635e-02 -2.959524e-02 6.015660e-02
## LEP_T2 1.445160e-01 -1.062939e-01 -9.307188e-02 -4.570599e-02
## ADIPO_T2 -6.813448e-02 2.299460e-02 -2.859411e-02 -1.615461e-02
## GOT_T2 -3.501413e-02 -5.997599e-02 -5.862521e-02 -1.236363e-01
## GPT_T2 -8.944025e-02 -4.007684e-02 -3.428534e-02 -7.958998e-02
## GGT_T2 -2.495619e-02 8.842103e-03 4.434617e-02 -5.037853e-02
## URICO_T2 6.160087e-02 3.683242e-02 5.654905e-02 1.024030e-02
## CREAT_T2 3.674025e-03 3.927328e-03 1.585899e-03 4.740251e-03
## UREA_T2 -3.197970e-02 -1.071864e-01 4.194784e-02 4.091856e-02
## HIERRO_T2 -8.365778e-02 2.588859e-02 -2.444644e-02 2.503881e-02
## TRANSF_T2 7.785915e-02 -6.306755e-02 3.694109e-02 -2.484630e-02
## FERR_T2 2.183598e-02 9.826416e-02 -7.859597e-03 5.483070e-02
## Ile_T2 -6.273345e-02 -1.868071e-02 -4.056459e-02 9.998340e-04
## Leu_T2 -1.997158e-02 1.656612e-02 -3.019838e-02 1.468440e-02
## Val_T2 -1.187340e-02 3.282317e-02 -1.890109e-02 -1.149232e-03
## Ala_T2 7.879184e-03 1.088893e-02 -7.198308e-02 1.313082e-02
## Pro_T2 -7.532557e-03 3.850072e-02 -8.450104e-02 -9.525547e-02
## Gly_T2 -2.433292e-02 2.625074e-03 -4.353830e-02 1.527929e-01
## Ser_T2 -3.126137e-02 -1.048416e-01 -6.180767e-02 1.301290e-01
## Trp_T2 2.335186e-02 5.660772e-02 6.739933e-02 -3.294382e-02
## Phe_T2 -2.847649e-02 2.443280e-02 -6.375444e-02 6.734116e-02
## Met_T2 -4.330558e-02 9.504658e-02 2.172273e-01 -8.193944e-02
## Orn_T2 1.545383e-02 -5.788844e-02 -5.925626e-02 5.763853e-02
## Arg_T2 -8.891368e-03 -1.923063e-02 -6.816146e-02 7.383555e-02
## His_T2 3.492720e-03 4.511903e-02 -1.896388e-02 -3.515106e-02
## Asn_T2 -4.206102e-02 1.079415e-03 -3.182359e-02 -6.703040e-02
## Asp_T2 -3.523461e-02 4.774158e-02 -9.843374e-02 -1.668647e-02
## Glu_T2 3.110277e-02 -8.787970e-03 -6.405101e-02 4.759389e-02
## Gln_T2 -6.721056e-02 -1.601074e-02 -5.372785e-02 -1.073045e-01
## Cit_T2 -3.934930e-03 -1.518388e-02 -1.478855e-02 -2.560720e-02
## Tyr_T2 -3.336147e-02 -1.149655e-02 -3.710853e-03 -5.850776e-02
## Thr_T2 -8.755445e-02 1.759466e-02 6.279467e-02 6.816541e-02
## Lys_T2 1.086899e-02 -3.429129e-02 -5.466171e-02 8.064243e-02
## Creatinine_T2 4.565924e-02 7.950216e-02 -2.342095e-02 5.287791e-02
## Kynurenine_T2 -3.876817e-03 2.256423e-03 1.487923e-02 1.266606e-02
## Putrescine_T2 1.789566e-02 1.064492e-01 2.711229e-04 2.141453e-02
## Sarcosine_T2 -3.949477e-02 1.069276e-01 -4.978811e-02 4.461097e-03
## Serotonin_T2 -6.193062e-02 4.545791e-03 -4.397605e-02 1.041369e-01
## Taurine_T2 5.835401e-02 1.595743e-02 -2.662333e-02 -4.287134e-02
## SDMA_T2 -6.719965e-03 7.138080e-03 -1.510335e-02 1.579310e-02
## C0_T2 4.990572e-02 6.824856e-03 -5.368667e-02 1.053199e-01
## C2_T2 2.626879e-02 7.378811e-02 3.790811e-02 1.200610e-01
## C3.OH_T2 1.900806e-05 -8.185863e-04 1.876807e-03 2.722125e-03
## C6..C4.1.DC._T2 -9.699887e-02 6.615711e-02 -8.976763e-03 -9.545094e-02
## C5.DC..C6.OH._T2 1.544145e-02 2.332764e-02 -3.952583e-02 1.311442e-02
## C7.DC_T2 -1.768305e-02 5.818780e-02 -6.453658e-02 -3.963598e-03
## C8_T2 -2.412043e-05 7.252282e-03 1.684626e-03 7.247103e-03
## C10_T2 9.098022e-04 9.002288e-03 3.789834e-03 1.232534e-02
## C10.1_T2 -1.646129e-03 1.842566e-03 2.288822e-03 3.456666e-03
## C10.2_T2 -7.716303e-04 3.742090e-05 3.040271e-03 6.499677e-04
## C14.1_T2 -6.832956e-04 5.790824e-03 4.320679e-03 5.876488e-03
## C14.2_T2 -1.346614e-03 2.573006e-03 2.508106e-03 3.918485e-03
## C16.1_T2 -1.456296e-03 2.445837e-03 2.187982e-03 2.307675e-03
## C16.2_T2 -1.333018e-03 1.218888e-03 2.413656e-03 1.584779e-03
## C16.2.OH_T2 -1.136716e-03 1.335409e-03 2.778955e-03 1.098748e-03
## C18.1_T2 -2.087711e-03 1.974950e-03 2.711001e-03 6.386003e-03
## C18.1.OH_T2 -1.139894e-03 1.153167e-03 3.147127e-03 1.240323e-03
## C18.2_T2 -2.337988e-03 3.140107e-03 3.062750e-03 4.513659e-03
## lysoPC.a.C14.0_T2 -1.290242e-02 2.311099e-02 7.247146e-02 6.462281e-02
## lysoPC.a.C16.0_T2 -3.373182e-03 -4.176391e-02 -1.167032e-02 -5.369710e-02
## lysoPC.a.C16.1_T2 2.093264e-02 -1.537314e-02 1.512132e-02 -3.985207e-02
## lysoPC.a.C17.0_T2 8.861219e-03 -1.214418e-02 -7.731017e-03 -9.642615e-04
## lysoPC.a.C18.0_T2 2.466081e-02 -4.193506e-02 9.119549e-03 -6.317242e-02
## lysoPC.a.C18.1_T2 6.525411e-02 -2.307826e-02 4.128789e-02 -4.989409e-02
## lysoPC.a.C18.2_T2 4.037329e-02 -4.363632e-02 -1.643024e-02 -9.078565e-02
## lysoPC.a.C20.3_T2 2.406327e-02 9.949472e-03 2.719932e-02 -1.898636e-02
## lysoPC.a.C20.4_T2 5.418730e-02 -5.300595e-02 -3.978769e-02 -6.029016e-02
## lysoPC.a.C24.0_T2 -2.263129e-03 -2.476125e-03 -7.596989e-03 5.339777e-03
## lysoPC.a.C26.0_T2 -4.201151e-02 3.090640e-02 6.476857e-02 -4.017543e-03
## lysoPC.a.C26.1_T2 -5.733265e-03 -1.140023e-03 -1.048346e-02 9.056414e-03
## lysoPC.a.C28.0_T2 -1.965011e-02 -7.322814e-02 -1.059041e-01 -1.391190e-02
## lysoPC.a.C28.1_T2 -2.487253e-03 -7.862979e-03 -2.094905e-02 1.282482e-02
## PC.aa.C24.0_T2 -7.619948e-02 -8.510572e-02 -6.746034e-02 5.207658e-02
## PC.aa.C28.1_T2 -7.522110e-04 5.902900e-03 9.915304e-03 -5.552527e-03
## PC.aa.C30.0_T2 -9.170630e-04 2.550480e-03 2.206746e-02 -6.476651e-03
## PC.aa.C32.0_T2 -7.837872e-03 -2.817911e-02 3.364653e-02 1.713642e-03
## PC.aa.C32.1_T2 4.655480e-02 -1.852516e-02 4.605838e-02 -1.089279e-01
## PC.aa.C32.3_T2 -1.039996e-03 -1.035697e-03 1.295425e-03 2.255788e-03
## PC.aa.C34.1_T2 -5.612380e-03 1.170510e-02 6.233425e-02 1.566495e-02
## PC.aa.C34.2_T2 -4.958195e-02 3.204665e-02 1.968838e-02 -2.717822e-02
## PC.aa.C34.3_T2 1.211790e-02 1.672660e-02 2.866664e-02 -5.746633e-02
## PC.aa.C34.4_T2 1.068949e-03 2.834393e-05 6.423944e-03 -6.812104e-03
## PC.aa.C36.0_T2 -1.046101e-03 -2.386681e-02 -3.644379e-02 7.040659e-03
## PC.aa.C36.1_T2 3.420778e-02 3.131029e-02 4.040003e-02 -2.274348e-02
## PC.aa.C36.2_T2 4.809134e-03 3.027541e-02 2.200022e-02 -5.029402e-02
## PC.aa.C36.3_T2 3.803844e-04 7.412622e-02 5.902022e-02 -2.014688e-02
## PC.aa.C36.4_T2 -2.893374e-03 3.393603e-03 1.594108e-02 -4.024144e-02
## PC.aa.C36.5_T2 -3.055038e-02 3.955556e-02 2.605335e-02 -7.736875e-02
## PC.aa.C38.0_T2 -2.082187e-03 -1.132232e-02 -6.934888e-03 -2.454134e-04
## PC.aa.C38.1_T2 -2.979076e-04 -4.261484e-02 -2.249659e-02 -5.492872e-02
## PC.aa.C38.3_T2 2.339337e-02 6.422720e-02 5.100430e-02 1.336287e-03
## PC.aa.C38.4_T2 1.016358e-02 6.017015e-03 3.244952e-02 -3.066981e-02
## PC.aa.C38.5_T2 3.269357e-02 4.001305e-02 7.216809e-02 -1.245234e-02
## PC.aa.C38.6_T2 -8.760519e-02 1.825248e-03 3.169386e-02 3.297879e-02
## PC.aa.C40.1_T2 -5.307732e-02 6.411882e-03 -7.720692e-02 -4.684757e-03
## PC.aa.C40.2_T2 1.158437e-02 -2.683461e-02 -5.094810e-02 2.816061e-02
## PC.aa.C40.3_T2 1.475254e-03 -1.924734e-02 -4.121777e-02 2.472294e-02
## PC.aa.C40.4_T2 1.102322e-02 1.291791e-03 -6.473533e-03 2.344694e-02
## PC.aa.C40.5_T2 1.902375e-02 1.717305e-02 3.592169e-02 9.882339e-03
## PC.aa.C40.6_T2 -4.100870e-02 -4.944293e-03 1.947667e-02 -1.188588e-02
## PC.aa.C42.0_T2 -1.579538e-03 -6.408509e-03 -1.117576e-02 1.870584e-03
## PC.aa.C42.1_T2 -1.011722e-03 -7.428280e-03 -1.043462e-02 5.213001e-03
## PC.aa.C42.2_T2 -5.006902e-03 -7.661909e-03 -1.544219e-02 7.878895e-03
## PC.aa.C42.4_T2 8.230681e-04 -5.648232e-03 -7.991772e-03 9.493368e-03
## PC.aa.C42.5_T2 -7.062597e-04 -3.432880e-03 -3.363849e-03 3.402878e-03
## PC.aa.C42.6_T2 4.180381e-02 5.380262e-02 -2.494620e-02 -4.220958e-02
## PC.ae.C30.0_T2 9.857296e-03 -2.142449e-02 4.635733e-02 -3.694638e-02
## PC.ae.C32.1_T2 1.056437e-02 -5.112871e-03 5.929425e-03 -2.678552e-02
## PC.ae.C32.2_T2 7.525500e-04 -3.487802e-03 -1.412438e-03 -1.984904e-04
## PC.ae.C34.0_T2 2.511828e-03 -1.256412e-03 1.643247e-03 1.725880e-04
## PC.ae.C34.1_T2 2.151178e-02 4.098190e-03 1.625254e-02 1.551675e-04
## PC.ae.C34.2_T2 2.247647e-02 2.699204e-02 1.797107e-02 -1.969179e-02
## PC.ae.C34.3_T2 1.057634e-02 2.191938e-02 7.978442e-03 -2.924764e-02
## PC.ae.C36.0_T2 -1.929937e-03 -7.905445e-03 2.060631e-03 2.000558e-03
## PC.ae.C36.1_T2 2.649298e-02 -7.847719e-02 -1.421712e-01 8.844985e-02
## PC.ae.C36.2_T2 3.689088e-03 -6.733470e-03 -4.224726e-02 3.415376e-02
## PC.ae.C36.3_T2 8.756143e-03 2.741273e-02 1.999911e-02 -1.406624e-02
## PC.ae.C36.4_T2 2.511441e-02 2.253640e-02 2.319460e-02 -4.572623e-02
## PC.ae.C36.5_T2 1.207346e-02 1.108545e-02 1.241656e-02 -6.442925e-02
## PC.ae.C38.0_T2 -6.143848e-03 8.566650e-04 1.158745e-02 -6.102618e-03
## PC.ae.C38.2_T2 1.679473e-02 -5.016050e-02 -9.801692e-02 6.129040e-02
## PC.ae.C38.3_T2 1.628826e-02 -4.505650e-02 -9.261536e-02 6.930505e-02
## PC.ae.C38.4_T2 3.060318e-02 1.147827e-02 -9.815141e-03 -8.952688e-03
## PC.ae.C38.5_T2 1.829871e-02 1.877486e-02 3.418726e-02 -2.928527e-02
## PC.ae.C38.6_T2 -2.568127e-03 1.006919e-02 1.301371e-02 -1.951128e-02
## PC.ae.C40.1_T2 2.920801e-03 -2.859503e-02 -4.416215e-02 1.693979e-02
## PC.ae.C40.2_T2 5.104808e-03 -2.067963e-02 -4.460841e-02 2.230650e-02
## PC.ae.C40.3_T2 1.478070e-02 -4.020752e-02 -7.947540e-02 5.722529e-02
## PC.ae.C40.4_T2 1.167521e-02 -1.922302e-02 -4.386429e-02 2.462032e-02
## PC.ae.C40.5_T2 -9.635409e-03 -1.845568e-03 -1.231624e-02 3.086145e-02
## PC.ae.C40.6_T2 -5.015901e-03 6.984081e-03 5.088424e-03 4.368430e-03
## PC.ae.C42.1_T2 5.750852e-03 -1.818105e-02 -3.227890e-02 1.963234e-02
## PC.ae.C42.2_T2 2.189558e-03 -1.426261e-02 -3.027909e-02 1.618346e-02
## PC.ae.C42.3_T2 -3.256397e-03 -1.141929e-02 -2.641010e-02 1.493025e-02
## PC.ae.C42.4_T2 -5.150273e-04 2.767487e-03 -1.386642e-02 4.704500e-03
## PC.ae.C42.5_T2 1.176983e-02 6.246561e-03 1.914015e-03 -3.892522e-03
## PC.ae.C44.3_T2 -1.715944e-02 1.112528e-02 -4.336781e-02 -8.376182e-03
## PC.ae.C44.4_T2 1.205511e-03 -1.017853e-03 -5.176044e-03 3.624032e-03
## PC.ae.C44.5_T2 1.296075e-02 2.601980e-02 -1.662745e-03 -1.120594e-02
## PC.ae.C44.6_T2 5.213568e-03 7.944752e-03 -2.879640e-03 -1.387815e-02
## SM..OH..C14.1_T2 -6.504266e-05 1.642401e-02 -2.284534e-02 2.180980e-02
## SM..OH..C16.1_T2 -9.184391e-03 6.326241e-03 -1.629110e-02 1.085252e-02
## SM..OH..C22.1_T2 -1.307015e-05 3.550178e-02 -2.815050e-04 -6.589501e-03
## SM..OH..C22.2_T2 7.592869e-03 3.482566e-02 -4.189834e-02 3.290540e-02
## SM..OH..C24.1_T2 -3.100937e-03 6.481472e-03 2.422095e-03 5.342837e-04
## SM.C16.0_T2 -2.083033e-02 5.175418e-02 -2.046697e-02 1.864689e-02
## SM.C16.1_T2 -2.910929e-02 1.867744e-02 5.097994e-03 2.096646e-02
## SM.C18.0_T2 -8.409755e-02 3.386352e-02 -5.466597e-02 1.805527e-02
## SM.C18.1_T2 -3.513079e-02 1.325355e-02 -4.367383e-02 3.792925e-02
## SM.C20.2_T2 -2.369519e-03 3.248041e-03 1.716455e-03 7.287069e-04
## SM.C24.0_T2 -1.705611e-02 4.081277e-02 -2.995803e-03 -9.755392e-04
## SM.C24.1_T2 -4.878942e-02 9.746449e-02 -1.800363e-02 4.525373e-02
## MEDDM_T4 9.375667e-03 -4.715606e-03 -2.700106e-03 1.185366e-03
## MEDCOL_T4 -2.905991e-03 5.713674e-03 1.121273e-03 2.368012e-03
## MEDINF_T4 3.184360e-03 -1.160451e-03 4.095999e-03 2.811296e-03
## MEDHTA_T4 5.575104e-03 -3.126832e-03 -5.776509e-03 1.338355e-03
## GLU_T4 1.531282e-02 -7.437063e-02 -4.972259e-02 -1.841961e-02
## INS_T4 9.701305e-02 -6.705788e-02 2.364217e-02 -6.026444e-02
## HOMA_T4 2.767984e-02 -3.037831e-02 9.135631e-03 -2.986632e-02
## HBA1C_T4 4.805742e-03 1.298056e-02 1.539079e-03 2.262702e-02
## HBA1C.mmol.mol_T4 -1.919091e-03 2.461866e-02 -2.060330e-02 5.200551e-02
## PESO_T4 -1.237741e-02 5.213147e-02 -4.464756e-02 1.723046e-02
## bmi_T4 5.941836e-03 3.496368e-02 -7.038966e-02 3.919279e-02
## CC_T4 3.398367e-05 8.538546e-03 -7.051784e-05 2.776486e-05
## CINT_T4 1.038574e-03 5.766510e-02 -5.141747e-03 3.183460e-02
## CAD_T4 3.688257e-02 -1.049550e-02 -1.001525e-03 4.556738e-02
## TAD_T4 1.859987e-02 -3.115785e-02 2.428072e-02 4.360761e-02
## TAS_T4 2.059857e-02 7.207492e-03 1.521389e-02 3.137333e-02
## TG_T4 9.851057e-03 -1.807109e-02 -2.098855e-02 -2.835984e-02
## COL_T4 -4.023795e-02 -4.036589e-02 2.031726e-02 2.183079e-02
## LDL_T4 -1.336198e-02 -5.116587e-02 4.803542e-02 5.035156e-02
## HDL_T4 1.536171e-02 -3.914597e-02 -2.076336e-02 1.032260e-02
## VLDL_T4 4.506481e-02 -5.336568e-02 -4.231559e-02 -2.404274e-02
## PCR_T4 -8.730175e-02 -6.820554e-02 -6.628358e-02 4.278771e-04
## LEP_T4 -1.195295e-02 -6.094294e-02 -1.351342e-01 -5.621609e-02
## ADIPO_T4 -9.497587e-02 1.759113e-02 -3.835188e-02 -2.122840e-02
## GOT_T4 -1.716073e-02 -1.093425e-01 1.622295e-02 -6.203767e-02
## GPT_T4 -7.926390e-02 -1.209965e-01 -1.514575e-02 -7.208136e-02
## GGT_T4 -6.103930e-02 -2.918049e-02 4.003520e-02 -1.071619e-01
## URICO_T4 4.641773e-02 1.350547e-02 -3.514068e-03 -4.446251e-02
## CREAT_T4 1.528890e-03 -5.255960e-03 4.627117e-03 -1.364635e-03
## UREA_T4 -1.318951e-02 -9.664817e-02 2.661167e-02 3.694428e-02
## HIERRO_T4 1.345436e-01 1.672480e-03 -6.313214e-02 1.069178e-01
## TRANSF_T4 8.403574e-02 -3.307887e-02 1.256826e-02 -8.202724e-03
## FERR_T4 -1.483132e-02 6.496308e-02 -2.263683e-02 -1.464655e-02
## Ile_T4 -1.584069e-02 1.182269e-02 2.545157e-02 -3.545495e-02
## Leu_T4 9.827905e-03 3.605711e-02 4.905854e-02 -1.570006e-02
## Val_T4 2.362936e-02 4.986030e-02 -4.803926e-03 5.006326e-03
## Ala_T4 4.202115e-02 -2.898063e-02 -3.351849e-02 8.394300e-04
## Pro_T4 5.673297e-02 8.061497e-02 -1.011808e-01 -8.311945e-02
## Gly_T4 2.134783e-02 -6.508990e-03 -5.637388e-03 5.533592e-02
## Ser_T4 -3.719768e-02 -3.256816e-02 1.046736e-01 7.916213e-02
## Trp_T4 8.627060e-02 1.301158e-03 3.169436e-02 3.567947e-02
## Phe_T4 -2.653100e-02 3.317093e-02 2.703264e-02 -3.995161e-02
## Met_T4 -1.178148e-01 -1.307719e-03 -2.532248e-02 -5.443656e-02
## Orn_T4 3.396041e-02 -2.406326e-02 -1.167396e-02 -9.885195e-04
## Arg_T4 4.404821e-02 5.443284e-03 -2.207176e-02 2.038828e-02
## His_T4 4.727921e-03 6.799257e-02 -6.592408e-03 6.372457e-03
## Asn_T4 2.297180e-02 -2.867287e-02 5.032455e-03 -3.727870e-02
## Asp_T4 4.320115e-02 -3.607691e-02 6.753731e-02 -3.056107e-02
## Glu_T4 6.168194e-02 8.999204e-03 9.338409e-02 1.426145e-02
## Gln_T4 -4.406654e-02 -5.482482e-02 7.896679e-02 2.929557e-02
## Cit_T4 -1.722345e-02 -3.349623e-02 -5.517251e-02 4.457848e-02
## Tyr_T4 9.124156e-03 -4.981697e-03 -6.882342e-02 -6.003172e-02
## Thr_T4 1.092593e-01 -5.769026e-02 -3.930174e-03 5.964011e-03
## Lys_T4 2.158478e-02 -9.238020e-02 1.147208e-01 4.054135e-02
## Creatinine_T4 9.161301e-02 -2.103046e-02 1.432104e-02 2.878718e-05
## Kynurenine_T4 9.065129e-02 -5.703054e-02 7.016001e-02 2.555024e-02
## Putrescine_T4 -1.598576e-02 4.899005e-02 -1.206852e-02 1.012728e-01
## Sarcosine_T4 5.513152e-02 6.123845e-02 -3.151420e-02 -6.165565e-02
## Serotonin_T4 -6.784092e-02 2.221400e-02 -3.324008e-02 9.927074e-02
## Taurine_T4 -4.555942e-02 -9.764327e-02 6.540877e-02 -2.940683e-02
## SDMA_T4 8.995936e-03 2.236678e-03 -1.724019e-03 3.232206e-03
## C0_T4 1.490256e-02 2.649854e-02 -5.917645e-02 3.499645e-02
## C2_T4 6.756532e-02 1.261699e-02 1.321794e-02 2.308569e-02
## C3.OH_T4 3.838651e-04 3.104994e-03 2.495082e-03 3.443113e-03
## C6..C4.1.DC._T4 4.082851e-02 6.612392e-02 7.651801e-02 -4.155221e-02
## C5.DC..C6.OH._T4 7.181940e-02 -1.250130e-02 7.342475e-03 5.700975e-02
## C7.DC_T4 3.494437e-02 -3.299639e-02 7.039747e-04 2.537542e-02
## C8_T4 1.300244e-03 7.865992e-03 2.040908e-03 5.163441e-03
## C10_T4 -1.521317e-03 7.500242e-03 1.862983e-03 3.318611e-03
## C10.1_T4 3.384993e-04 2.750351e-03 1.193753e-03 6.287707e-04
## C10.2_T4 1.161433e-03 9.993309e-04 3.944564e-03 -1.074417e-04
## C14.1_T4 2.709125e-03 1.728858e-03 3.996609e-03 2.326651e-03
## C14.2_T4 6.919060e-04 -9.752861e-05 4.849237e-03 2.649213e-03
## C16.1_T4 1.879098e-02 -1.048728e-02 -1.025397e-02 3.751389e-02
## C16.2_T4 8.195999e-05 9.420312e-04 3.574284e-03 9.823322e-04
## C16.2.OH_T4 1.750015e-02 -1.067913e-02 -1.067683e-02 3.694400e-02
## C18.1_T4 3.643137e-04 -7.939965e-04 3.731587e-03 9.539115e-04
## C18.1.OH_T4 -5.075112e-04 1.044260e-03 2.921219e-03 1.065857e-03
## C18.2_T4 1.854538e-04 7.450239e-04 3.789210e-03 6.083981e-04
## lysoPC.a.C16.0_T4 8.411185e-02 2.444081e-02 3.253363e-02 -6.602494e-03
## lysoPC.a.C16.1_T4 5.626986e-03 1.013164e-02 -9.507944e-03 -3.903546e-02
## lysoPC.a.C17.0_T4 2.382299e-02 9.234446e-03 -2.246153e-03 1.796287e-02
## lysoPC.a.C18.0_T4 7.514289e-02 3.065902e-02 4.205850e-02 3.422429e-02
## lysoPC.a.C18.1_T4 3.638672e-02 -3.418943e-03 -8.331861e-03 -1.760473e-02
## lysoPC.a.C18.2_T4 3.153534e-02 7.739094e-03 -2.433305e-02 -4.873898e-02
## lysoPC.a.C20.3_T4 -1.034663e-05 1.946724e-02 -1.294383e-02 -3.139607e-02
## lysoPC.a.C20.4_T4 1.053791e-01 -3.844102e-02 -3.133316e-02 -6.346333e-02
## lysoPC.a.C24.0_T4 1.384890e-03 2.447628e-05 9.207406e-03 5.225380e-03
## lysoPC.a.C26.0_T4 3.073576e-02 -4.883490e-02 4.100989e-02 3.154628e-02
## lysoPC.a.C26.1_T4 3.544097e-03 1.874351e-03 8.646300e-03 5.656429e-03
## lysoPC.a.C28.0_T4 -5.568138e-02 -8.477421e-02 9.116639e-02 9.249561e-02
## lysoPC.a.C28.1_T4 9.064796e-03 1.158993e-03 6.704579e-03 7.530077e-03
## PC.aa.C24.0_T4 6.303839e-02 9.310462e-03 6.984261e-02 -7.674350e-03
## PC.aa.C28.1_T4 2.325534e-02 -7.587546e-03 1.823628e-02 1.391811e-02
## PC.aa.C30.0_T4 -6.889432e-04 -1.555062e-02 1.238168e-02 -8.163480e-03
## PC.aa.C32.0_T4 8.410499e-03 -1.451199e-02 1.144552e-02 -3.574214e-02
## PC.aa.C32.1_T4 -4.154297e-02 1.006364e-02 -3.246710e-02 -5.969915e-02
## PC.aa.C32.3_T4 -4.673074e-04 1.543659e-03 2.561619e-03 1.514657e-03
## PC.aa.C34.1_T4 -1.962152e-02 -3.592362e-03 1.071038e-02 1.392639e-04
## PC.aa.C34.2_T4 -2.320414e-02 4.550460e-02 -2.154261e-03 1.138052e-02
## PC.aa.C34.3_T4 -5.791237e-02 6.268274e-02 -6.266998e-02 -1.047678e-02
## PC.aa.C34.4_T4 -3.816432e-03 3.444104e-03 -3.857447e-03 -1.795302e-04
## PC.aa.C36.0_T4 -7.420024e-03 6.618358e-03 -1.326989e-03 1.028064e-02
## PC.aa.C36.1_T4 -3.998255e-02 -1.501742e-02 6.065667e-02 3.111147e-02
## PC.aa.C36.2_T4 -3.469857e-02 1.328543e-02 8.209447e-03 3.247730e-02
## PC.aa.C36.3_T4 -5.293483e-02 6.177476e-02 5.790445e-03 -1.059155e-02
## PC.aa.C36.4_T4 2.095114e-02 -4.052000e-03 -7.465802e-03 -3.795882e-02
## PC.aa.C36.5_T4 -5.078897e-02 3.036902e-02 -6.545073e-02 2.855971e-02
## PC.aa.C38.0_T4 -2.965355e-02 -8.691793e-03 6.667009e-03 1.148638e-02
## PC.aa.C38.1_T4 9.438477e-03 1.476308e-02 3.357674e-03 1.721104e-02
## PC.aa.C38.3_T4 -5.505681e-02 4.007609e-02 6.975127e-03 -7.552169e-02
## PC.aa.C38.4_T4 -8.876724e-03 -2.166112e-02 -1.535632e-02 -4.785513e-02
## PC.aa.C38.5_T4 9.925727e-03 -8.110210e-03 -1.957103e-02 -9.000037e-03
## PC.aa.C38.6_T4 -8.614923e-02 1.190750e-02 -2.800232e-02 7.542684e-02
## PC.aa.C40.1_T4 5.902004e-02 -5.533734e-02 8.892759e-02 -8.880476e-02
## PC.aa.C40.2_T4 1.109472e-02 4.519020e-03 2.188598e-02 9.198743e-03
## PC.aa.C40.3_T4 5.289911e-03 3.513017e-03 1.779659e-02 3.758991e-03
## PC.aa.C40.4_T4 8.021023e-03 3.640565e-03 3.390468e-02 -7.746156e-03
## PC.aa.C40.5_T4 -9.181247e-03 -5.614183e-03 1.789618e-02 -2.571620e-02
## PC.aa.C40.6_T4 -1.286915e-01 -1.894850e-02 -2.607117e-02 6.726414e-02
## PC.aa.C42.0_T4 6.478901e-03 -1.366334e-04 4.241212e-03 -5.958891e-03
## PC.aa.C42.1_T4 1.220505e-03 1.743250e-03 5.611076e-03 1.033000e-03
## PC.aa.C42.2_T4 -5.171334e-03 3.157764e-03 9.734613e-03 4.090590e-03
## PC.aa.C42.4_T4 -3.239655e-03 3.288130e-03 1.226676e-02 4.975388e-03
## PC.aa.C42.5_T4 -1.380341e-03 2.601796e-03 5.253784e-03 2.275272e-03
## PC.aa.C42.6_T4 4.521876e-02 -9.247101e-02 7.104816e-02 5.244620e-03
## PC.ae.C30.0_T4 -1.237983e-02 -6.493066e-02 3.785597e-02 3.199201e-02
## PC.ae.C32.1_T4 1.871629e-02 -1.346502e-02 2.451525e-03 -1.472791e-02
## PC.ae.C32.2_T4 -9.893207e-04 3.817871e-03 3.981198e-04 2.023999e-03
## PC.ae.C34.0_T4 9.590224e-04 -2.655974e-03 1.159839e-03 -8.383511e-04
## PC.ae.C34.1_T4 5.330578e-03 -2.163956e-02 -2.842625e-03 -1.000097e-02
## PC.ae.C34.2_T4 1.730273e-02 2.649407e-02 -1.963397e-02 -4.599712e-03
## PC.ae.C34.3_T4 1.299543e-02 5.122898e-02 -1.032637e-02 1.363244e-03
## PC.ae.C36.0_T4 -2.730378e-03 -2.564113e-03 8.105480e-03 2.957311e-03
## PC.ae.C36.1_T4 -4.860999e-02 2.311193e-02 5.425870e-02 2.942109e-02
## PC.ae.C36.2_T4 5.703749e-03 3.256920e-02 -1.312221e-02 5.230160e-02
## PC.ae.C36.3_T4 -7.020505e-03 1.637412e-02 6.033171e-03 -3.454729e-03
## PC.ae.C36.4_T4 2.997787e-02 -5.461901e-04 1.087326e-02 -4.245943e-02
## PC.ae.C36.5_T4 8.332583e-03 5.412611e-03 -3.152128e-02 -1.715636e-02
## PC.ae.C38.0_T4 -2.460732e-02 8.462289e-03 -1.034089e-02 1.645968e-02
## PC.ae.C38.2_T4 -8.157852e-03 1.283343e-02 4.899620e-02 3.231701e-02
## PC.ae.C38.3_T4 3.526950e-02 1.723112e-02 4.566952e-02 3.332654e-02
## PC.ae.C38.4_T4 4.638408e-02 -2.148264e-02 1.346489e-02 -1.157717e-02
## PC.ae.C38.5_T4 3.489666e-02 -2.110927e-02 1.518068e-02 -2.930928e-02
## PC.ae.C38.6_T4 -1.151427e-02 7.437395e-03 -1.196848e-02 1.100663e-02
## PC.ae.C40.1_T4 7.223748e-03 7.197248e-04 1.197322e-02 1.420845e-02
## PC.ae.C40.2_T4 7.206387e-03 2.505834e-04 1.681976e-02 1.223638e-02
## PC.ae.C40.3_T4 2.816495e-02 5.975287e-03 4.076077e-02 2.781941e-02
## PC.ae.C40.4_T4 3.175338e-02 -6.604172e-03 3.606933e-02 5.960865e-03
## PC.ae.C40.5_T4 -1.076078e-02 6.601024e-03 5.699620e-02 1.010308e-02
## PC.ae.C40.6_T4 -1.118982e-02 1.986514e-04 2.618872e-03 1.444210e-02
## PC.ae.C42.1_T4 4.725414e-03 4.159007e-03 9.864597e-03 8.464361e-03
## PC.ae.C42.2_T4 6.285191e-03 9.543061e-04 8.446800e-03 4.647624e-03
## PC.ae.C42.3_T4 -6.116317e-03 7.419067e-03 1.585936e-02 6.189339e-03
## PC.ae.C42.4_T4 1.563540e-02 8.618701e-06 1.628043e-02 1.473037e-03
## PC.ae.C42.5_T4 1.276672e-02 -3.592395e-03 2.371201e-02 -2.540933e-02
## PC.ae.C44.3_T4 -3.480361e-03 1.984622e-03 7.966998e-03 1.807225e-03
## PC.ae.C44.4_T4 3.413962e-03 1.610075e-03 4.345039e-03 -3.133981e-03
## PC.ae.C44.5_T4 4.503514e-02 -8.292321e-03 4.824990e-03 -3.094764e-02
## PC.ae.C44.6_T4 2.741137e-02 -1.969836e-03 6.692098e-03 -2.004821e-02
## SM..OH..C14.1_T4 2.440396e-02 9.285132e-03 -1.250743e-02 2.643307e-02
## SM..OH..C16.1_T4 -4.872765e-03 -2.321801e-03 -7.461149e-03 1.069332e-02
## SM..OH..C22.1_T4 1.650875e-02 1.332188e-02 1.841842e-02 5.943881e-02
## SM..OH..C22.2_T4 3.230161e-02 4.260669e-02 -1.998289e-03 4.305373e-02
## SM..OH..C24.1_T4 1.353230e-04 3.638098e-03 3.688542e-03 5.231323e-03
## SM.C16.0_T4 1.833635e-02 2.438541e-03 2.775730e-02 2.614842e-02
## SM.C16.1_T4 1.696420e-02 3.968417e-02 1.238405e-02 3.986600e-02
## SM.C18.0_T4 -2.520796e-02 -2.259156e-02 3.757762e-03 -2.285185e-02
## SM.C18.1_T4 -8.758456e-03 1.190193e-02 -1.444105e-02 1.218703e-02
## SM.C20.2_T4 -1.672315e-03 2.041671e-03 1.356264e-03 -9.266718e-04
## SM.C24.0_T4 -1.001864e-02 -8.351687e-03 8.862881e-02 4.554744e-02
## SM.C24.1_T4 5.891252e-04 4.626708e-02 7.878966e-03 -1.103599e-02
## MEDDM_T5 -1.492733e-02 8.154353e-03 9.101135e-03 1.048376e-03
## MEDCOL_T5 -1.492733e-02 8.154353e-03 9.101135e-03 1.048376e-03
## MEDINF_T5 -1.081073e-02 5.106787e-03 6.656784e-03 3.726885e-03
## MEDHTA_T5 -4.214855e-03 2.734542e-03 3.296751e-03 1.463147e-03
## GLU_T5 8.043309e-02 -1.207994e-02 -1.671121e-02 -1.665350e-02
## INS_T5 7.301582e-02 -1.098654e-02 -8.712424e-03 -4.298040e-02
## HOMA_T5 2.931704e-02 -6.754483e-03 -5.668148e-03 -2.047715e-02
## HBA1C_T5 1.223229e-02 1.717109e-02 8.631266e-03 1.164594e-02
## HBA1C.mmol.mol_T5 2.350175e-02 3.924956e-02 3.340921e-03 1.478818e-02
## PESO_T5 3.673310e-02 2.014526e-02 -1.386006e-02 4.964842e-03
## bmi_T5 4.696449e-02 2.280369e-02 -3.993394e-03 2.449037e-02
## CC_T5 -1.979421e-03 1.165159e-03 5.220987e-03 4.017664e-03
## CINT_T5 3.942444e-02 1.349129e-03 -1.004816e-02 2.141498e-02
## CAD_T5 1.097828e-01 2.031511e-02 -6.425707e-03 1.139558e-02
## TAD_T5 1.005277e-02 -2.492230e-02 5.989210e-02 3.025281e-02
## TAS_T5 1.335740e-02 2.338894e-02 -1.545072e-02 3.365492e-02
## TG_T5 2.180793e-02 7.056522e-02 1.578080e-02 3.630547e-02
## COL_T5 2.047714e-02 9.748486e-03 5.047338e-02 -2.760246e-02
## LDL_T5 1.644639e-02 8.970165e-03 6.297824e-02 -1.178856e-02
## HDL_T5 6.761987e-02 -2.888907e-02 4.568486e-02 -6.432973e-02
## VLDL_T5 6.703063e-02 9.645210e-03 2.071417e-03 1.662894e-02
## PCR_T5 -5.144323e-03 -3.194223e-02 -2.855846e-02 1.554260e-02
## LEP_T5 2.511148e-02 -2.664271e-02 -1.180057e-01 -7.336785e-02
## ADIPO_T5 -5.975505e-02 3.593471e-02 4.398430e-02 -4.003941e-02
## GOT_T5 4.818860e-02 -1.026677e-01 -3.642833e-03 2.256528e-03
## GPT_T5 7.307368e-03 -5.210322e-02 -2.632477e-02 -4.476496e-03
## GGT_T5 5.489090e-02 -5.308075e-02 1.516896e-02 1.370718e-02
## URICO_T5 6.969940e-02 1.425892e-02 -1.182312e-02 -1.580250e-03
## CREAT_T5 2.836846e-03 -4.840654e-04 -1.167632e-04 2.655480e-03
## UREA_T5 -8.324976e-02 -4.535956e-02 -1.324840e-02 9.828564e-02
## HIERRO_T5 -1.118394e-02 7.903840e-02 5.634485e-02 2.086069e-02
## TRANSF_T5 1.326972e-01 -3.004051e-02 -1.969505e-02 6.625238e-03
## FERR_T5 -5.795884e-02 5.506407e-03 -4.303407e-02 -2.419635e-02
## Ile_T5 -2.462488e-02 6.809796e-02 2.663435e-02 1.705043e-02
## Leu_T5 -3.820974e-02 1.037080e-01 -4.524245e-03 1.895827e-02
## Val_T5 -2.826975e-02 9.506843e-02 -3.938249e-02 5.845612e-02
## Ala_T5 -2.444334e-02 3.754688e-04 1.057012e-02 -2.485855e-02
## Pro_T5 -6.138517e-02 8.456734e-02 -4.407137e-03 -8.928364e-02
## Gly_T5 2.256159e-02 -3.808204e-03 9.046876e-03 6.329486e-02
## Ser_T5 -2.051900e-02 -3.894390e-02 2.399399e-02 -8.501249e-03
## Trp_T5 5.241202e-02 1.856615e-02 -4.766627e-02 3.510451e-02
## Phe_T5 -6.803265e-02 6.525385e-02 -2.438022e-02 -1.686608e-02
## Met_T5 3.281770e-02 1.370370e-02 -2.627611e-02 -6.783614e-02
## Orn_T5 -1.289099e-02 -3.748112e-02 -2.048279e-02 -3.706453e-02
## Arg_T5 4.437063e-02 -1.239266e-02 3.887023e-03 7.998977e-02
## His_T5 -5.622365e-02 6.128382e-02 2.045188e-03 2.282216e-02
## Asn_T5 -1.014877e-01 -2.524992e-02 4.768320e-03 -8.965462e-02
## Asp_T5 -5.716459e-02 5.371626e-02 -4.437566e-02 -2.787588e-02
## Glu_T5 6.650561e-02 9.760607e-03 2.680373e-02 3.352352e-02
## Gln_T5 -1.054887e-01 -1.600436e-02 -1.886931e-02 -5.499753e-02
## Cit_T5 -1.072702e-01 2.702962e-02 -4.672066e-02 3.822929e-02
## Tyr_T5 -2.121925e-02 6.568040e-03 -1.632930e-02 -1.047446e-01
## Thr_T5 -6.406524e-02 6.102821e-02 -5.416587e-02 -2.893787e-02
## Lys_T5 6.169776e-02 7.071954e-02 -3.539628e-02 6.721611e-02
## Creatinine_T5 -2.950075e-02 4.622804e-02 -2.899898e-04 -2.416784e-02
## Kynurenine_T5 9.529266e-02 -9.706311e-03 -7.624938e-02 -6.400807e-03
## Putrescine_T5 -6.426129e-02 1.605630e-02 -5.318474e-02 1.671161e-02
## Sarcosine_T5 -7.629812e-02 8.715425e-02 1.079893e-02 -1.901496e-02
## Serotonin_T5 -6.875483e-02 -1.812511e-02 -2.494936e-02 1.013165e-01
## Taurine_T5 -6.661825e-02 8.476342e-02 -5.257247e-02 -1.536932e-01
## SDMA_T5 1.273393e-03 6.669647e-03 -1.496250e-03 7.472402e-03
## C0_T5 7.107287e-02 4.364648e-02 -3.889479e-02 7.017129e-02
## C2_T5 6.229803e-02 8.389036e-02 -1.027343e-02 5.141901e-02
## C3.OH_T5 5.766425e-04 1.699025e-03 3.407612e-03 4.513155e-03
## C6..C4.1.DC._T5 -5.541216e-02 9.998629e-02 3.145246e-02 -1.735505e-01
## C5.DC..C6.OH._T5 -3.419164e-02 -7.999951e-03 -9.979929e-03 5.164655e-02
## C7.DC_T5 -5.082467e-02 1.549199e-02 -2.190862e-02 1.798675e-02
## C8_T5 2.433200e-05 6.619215e-03 2.536661e-03 1.160011e-02
## C10_T5 4.648504e-04 1.086576e-02 -7.871088e-04 1.248654e-02
## C10.1_T5 -3.597069e-03 7.316071e-02 -5.112992e-02 2.521614e-02
## C10.2_T5 -2.879248e-04 2.082646e-03 2.910898e-03 2.785591e-03
## C14.1_T5 1.982849e-04 3.174771e-03 2.188628e-03 2.752668e-03
## C14.2_T5 -3.805271e-04 2.127277e-03 2.642841e-03 2.343229e-03
## C16.1_T5 -4.839571e-04 1.503781e-03 3.289972e-03 1.847540e-03
## C16.2_T5 -7.334044e-04 9.997878e-04 2.910110e-03 1.370850e-03
## C16.2.OH_T5 4.753160e-02 -4.352040e-02 6.514721e-02 5.118032e-02
## C18.1_T5 -2.728360e-04 1.327440e-03 2.544430e-03 9.088137e-04
## C18.1.OH_T5 -5.448195e-04 9.417668e-04 3.162776e-03 1.654159e-03
## C18.2_T5 -7.275322e-04 1.445578e-03 3.448112e-03 1.843226e-03
## lysoPC.a.C16.0_T5 -5.918469e-02 6.397535e-03 2.554940e-02 -4.400208e-02
## lysoPC.a.C16.1_T5 -6.554518e-02 1.304287e-02 2.660929e-02 -6.174621e-02
## lysoPC.a.C17.0_T5 -2.032970e-02 1.330498e-03 -4.016691e-03 -1.379653e-03
## lysoPC.a.C18.0_T5 -4.165100e-02 -2.711865e-02 2.592887e-02 -3.522536e-02
## lysoPC.a.C18.1_T5 -8.015555e-02 -1.839953e-02 3.193164e-02 -7.169892e-02
## lysoPC.a.C18.2_T5 -3.753834e-02 -4.753697e-02 3.439477e-02 -6.326926e-02
## lysoPC.a.C20.3_T5 1.504407e-02 -9.299572e-03 2.684530e-02 -3.065565e-02
## lysoPC.a.C20.4_T5 2.217338e-02 -4.086197e-02 2.422893e-02 -7.261905e-02
## lysoPC.a.C24.0_T5 -7.079186e-03 2.751878e-03 2.488362e-03 5.884898e-03
## lysoPC.a.C26.0_T5 -1.215757e-02 5.869605e-03 5.608570e-03 7.231116e-03
## lysoPC.a.C26.1_T5 -9.835987e-04 3.011186e-03 3.514608e-03 7.575950e-03
## lysoPC.a.C28.0_T5 -6.705423e-02 -4.182490e-02 -9.439820e-03 1.881973e-02
## lysoPC.a.C28.1_T5 -3.589007e-03 3.963810e-03 3.297258e-03 5.404086e-03
## PC.aa.C24.0_T5 -1.520165e-02 -9.717384e-02 -1.207664e-02 -8.662240e-03
## PC.aa.C28.1_T5 4.815877e-03 4.750510e-03 3.671117e-03 1.007975e-02
## PC.aa.C30.0_T5 -1.374898e-03 5.457477e-03 4.600135e-03 2.892339e-03
## PC.aa.C32.0_T5 -2.441472e-02 7.598446e-03 -2.607389e-03 -4.355055e-02
## PC.aa.C32.1_T5 -1.126731e-03 9.078799e-03 -9.570046e-03 -2.334517e-02
## PC.aa.C32.3_T5 -1.578368e-03 2.174330e-03 2.471459e-03 2.899191e-03
## PC.aa.C34.1_T5 9.389333e-03 -1.924202e-02 -8.884574e-03 -1.189911e-02
## PC.aa.C34.2_T5 7.398243e-03 -5.208666e-03 -1.117389e-02 3.657786e-02
## PC.aa.C34.3_T5 5.098545e-02 1.839193e-02 -1.432668e-02 3.243323e-02
## PC.aa.C34.4_T5 5.298588e-03 3.101970e-03 2.614447e-03 3.720891e-03
## PC.aa.C36.0_T5 -2.881344e-02 9.024540e-03 3.277729e-03 2.046271e-02
## PC.aa.C36.1_T5 -6.005119e-03 -4.306534e-02 3.485792e-03 -2.037038e-02
## PC.aa.C36.2_T5 1.900708e-02 -3.408053e-02 -1.928141e-02 1.179801e-02
## PC.aa.C36.3_T5 3.029553e-02 1.626781e-02 -7.063769e-03 -1.974275e-03
## PC.aa.C36.4_T5 5.684072e-02 -1.205967e-02 -4.310921e-03 -2.387016e-02
## PC.aa.C36.5_T5 1.740887e-03 5.066035e-02 -4.086140e-02 6.129109e-02
## PC.aa.C38.0_T5 -4.983680e-02 9.381092e-03 -3.681809e-03 -1.506852e-03
## PC.aa.C38.1_T5 -4.287909e-02 1.185873e-02 1.147681e-02 -2.140268e-03
## PC.aa.C38.3_T5 6.422314e-02 -1.111482e-02 2.165365e-02 9.678585e-03
## PC.aa.C38.4_T5 8.537931e-02 -4.623884e-02 6.121190e-03 2.406207e-03
## PC.aa.C38.5_T5 4.695444e-02 -1.557805e-02 -2.675484e-03 1.486678e-02
## PC.aa.C38.6_T5 -2.500727e-02 2.181494e-02 -1.908359e-02 7.894354e-02
## PC.aa.C40.1_T5 -7.594319e-02 -2.106902e-02 1.277025e-02 4.953116e-02
## PC.aa.C40.2_T5 -2.050390e-02 7.185354e-03 1.642061e-02 4.866025e-03
## PC.aa.C40.3_T5 -2.798137e-02 7.885703e-03 1.582498e-02 4.322096e-03
## PC.aa.C40.4_T5 -8.294594e-03 -1.122626e-03 2.449390e-02 7.383588e-03
## PC.aa.C40.5_T5 8.074072e-03 -2.850004e-02 2.502696e-02 1.949720e-02
## PC.aa.C40.6_T5 1.407665e-03 6.023764e-03 -1.656764e-02 6.415946e-02
## PC.aa.C42.0_T5 -7.193645e-03 4.476364e-03 3.624367e-03 -8.142157e-03
## PC.aa.C42.1_T5 -5.611133e-03 3.412564e-03 3.592221e-03 -3.197704e-03
## PC.aa.C42.2_T5 -1.463151e-02 4.798664e-03 8.411637e-03 2.662988e-03
## PC.aa.C42.4_T5 -1.184998e-02 3.246323e-03 1.143670e-02 3.029367e-03
## PC.aa.C42.5_T5 -8.225948e-03 2.328199e-03 7.573494e-03 1.743895e-03
## PC.aa.C42.6_T5 4.668949e-03 -3.571032e-02 -3.024078e-02 -4.891028e-02
## PC.ae.C30.0_T5 -1.336987e-02 1.731220e-02 -3.265876e-02 -1.187367e-02
## PC.ae.C32.1_T5 5.820305e-03 -4.413149e-03 -5.258365e-03 -1.841190e-02
## PC.ae.C32.2_T5 -4.604439e-03 7.145050e-04 1.415791e-03 -8.614840e-04
## PC.ae.C34.0_T5 5.533407e-04 -1.162461e-03 1.876335e-03 -1.209878e-03
## PC.ae.C34.1_T5 1.735333e-02 -1.500111e-03 -1.834309e-02 -2.071614e-02
## PC.ae.C34.2_T5 1.771596e-02 6.743035e-04 -2.452367e-02 -1.585102e-02
## PC.ae.C34.3_T5 1.249906e-02 5.383625e-03 -3.771691e-03 -2.153739e-02
## PC.ae.C36.0_T5 -9.122838e-03 -2.552523e-03 4.283442e-03 -2.025777e-03
## PC.ae.C36.1_T5 -6.509284e-02 2.016282e-02 2.709270e-02 9.825684e-03
## PC.ae.C36.2_T5 -1.956342e-02 4.213038e-03 -2.829247e-02 2.533855e-02
## PC.ae.C36.3_T5 -1.283916e-03 1.704888e-02 -5.602802e-03 -1.581490e-02
## PC.ae.C36.4_T5 3.046142e-02 -1.771018e-02 -2.621915e-02 -5.872472e-02
## PC.ae.C36.5_T5 1.655516e-02 -2.728881e-02 -1.924893e-02 -2.953620e-02
## PC.ae.C38.0_T5 -3.668063e-03 4.203321e-03 -2.159609e-03 1.558643e-02
## PC.ae.C38.2_T5 -6.796540e-02 2.532005e-02 3.633431e-02 1.738817e-02
## PC.ae.C38.3_T5 3.226777e-02 8.062792e-03 3.125532e-02 2.366371e-02
## PC.ae.C38.4_T5 3.522579e-02 -9.024663e-03 -7.899123e-03 -1.423163e-02
## PC.ae.C38.5_T5 -8.880838e-03 -8.892285e-03 -1.086085e-02 -6.330055e-02
## PC.ae.C38.6_T5 -1.231890e-02 2.605106e-03 -1.924609e-02 -7.687933e-04
## PC.ae.C40.1_T5 -1.563262e-02 2.379945e-03 9.257024e-03 4.068045e-03
## PC.ae.C40.2_T5 -1.356979e-02 1.191084e-02 1.297754e-02 1.137412e-02
## PC.ae.C40.3_T5 2.098634e-02 7.848262e-03 3.351974e-02 1.776933e-02
## PC.ae.C40.4_T5 -7.106426e-03 -6.521422e-04 2.578670e-02 -1.631166e-03
## PC.ae.C40.5_T5 4.272696e-03 7.924883e-03 3.736924e-02 -4.166376e-03
## PC.ae.C40.6_T5 -1.241546e-02 7.759592e-03 5.897724e-04 5.738866e-03
## PC.ae.C42.1_T5 -7.878662e-03 4.312717e-03 1.008655e-02 3.926387e-03
## PC.ae.C42.2_T5 -1.034993e-02 6.861331e-03 9.628673e-03 6.968290e-04
## PC.ae.C42.3_T5 -1.699272e-02 1.003974e-02 1.052967e-02 1.180314e-03
## PC.ae.C42.4_T5 -6.745711e-03 4.608796e-03 7.736108e-03 -5.163520e-03
## PC.ae.C42.5_T5 1.156860e-02 -4.156430e-03 2.167070e-02 -2.389179e-02
## PC.ae.C44.3_T5 -9.403399e-03 4.281731e-03 6.593407e-03 1.875237e-03
## PC.ae.C44.4_T5 -2.388976e-03 4.136077e-03 6.354441e-03 -2.392169e-03
## PC.ae.C44.5_T5 1.720753e-02 7.691381e-03 -9.619912e-03 -3.338587e-02
## PC.ae.C44.6_T5 8.152685e-03 2.719654e-03 -2.807243e-03 -2.532016e-02
## SM..OH..C14.1_T5 1.351241e-02 1.608400e-02 -1.964000e-02 3.118450e-02
## SM..OH..C16.1_T5 6.221486e-03 6.600213e-03 -5.855184e-03 3.006906e-03
## SM..OH..C22.1_T5 1.029574e-02 1.630085e-02 -1.791714e-02 8.337666e-02
## SM..OH..C22.2_T5 2.595380e-02 4.500628e-02 -2.155923e-02 6.270444e-02
## SM..OH..C24.1_T5 -3.865653e-04 3.897812e-03 1.494272e-03 7.284430e-03
## SM.C16.0_T5 1.092952e-02 2.160591e-02 4.890286e-03 3.377397e-02
## SM.C16.1_T5 2.699232e-02 3.274674e-02 5.658439e-04 5.380719e-02
## SM.C18.0_T5 5.560081e-02 2.052028e-02 3.271713e-02 -3.880701e-02
## SM.C18.1_T5 6.950989e-02 3.380155e-02 5.275534e-03 -8.057623e-03
## SM.C20.2_T5 -7.482163e-04 3.915984e-03 2.728008e-03 1.183930e-03
## SM.C24.0_T5 -5.734913e-03 2.496196e-02 6.956574e-04 1.011805e-01
## SM.C24.1_T5 1.721927e-02 5.153144e-02 1.739368e-02 4.402552e-02
## PC21 PC22 PC23 PC24
## GLU_T0 -2.660904e-03 1.017133e-03 9.489369e-02 -1.463972e-01
## INS_T0 -7.664985e-02 1.472125e-02 5.694250e-02 -3.423064e-02
## HOMA_T0 -5.015224e-02 8.590032e-03 7.626397e-02 -6.799401e-02
## HBA1C_T0 -1.305859e-02 2.758540e-02 -1.241834e-02 1.445865e-02
## HBA1C.mmol.mol_T0 2.715487e-03 4.632943e-02 -2.868234e-02 1.883234e-02
## PESO_T0 4.358539e-02 -4.819771e-02 -1.975462e-02 1.690658e-03
## bmi_T0 8.194675e-02 -1.589245e-02 -3.442594e-03 3.159154e-02
## CC_T0 -5.557655e-03 -5.462141e-03 1.027548e-03 1.486506e-02
## CINT_T0 -4.587460e-03 -2.168875e-02 1.554266e-02 4.766560e-02
## CAD_T0 -7.904624e-03 9.704495e-02 -2.746324e-02 -1.341494e-02
## TAD_T0 8.188016e-02 -1.373494e-02 -3.020119e-02 2.910485e-02
## TAS_T0 7.059031e-02 -1.926044e-02 6.153269e-02 5.182175e-02
## TG_T0 -3.036266e-02 9.404918e-02 -2.861136e-02 5.869965e-02
## COL_T0 -3.580579e-02 -7.037485e-03 4.684837e-02 4.143166e-02
## LDL_T0 -4.026272e-02 -2.871084e-02 -4.250826e-03 2.830872e-02
## HDL_T0 -4.035605e-02 -1.037590e-01 1.392393e-01 -2.476838e-02
## VLDL_T0 -3.158190e-02 9.553066e-02 -2.886993e-02 5.966530e-02
## PCR_T0 1.981787e-02 -1.004087e-01 7.348809e-02 -1.285529e-02
## LEP_T0 8.375946e-02 6.697929e-03 -9.550603e-02 1.897002e-03
## ADIPO_T0 1.058470e-02 -9.762073e-02 -7.889339e-02 -5.278824e-02
## GOT_T0 5.835502e-02 9.555714e-02 8.792123e-02 -1.327353e-01
## GPT_T0 -2.275780e-02 4.831187e-02 3.150132e-02 -8.540781e-02
## GGT_T0 2.819636e-02 -2.465380e-02 -5.291562e-02 -4.976560e-02
## URICO_T0 7.319150e-03 2.819820e-02 -3.885160e-02 2.060979e-04
## CREAT_T0 -1.127715e-02 1.204082e-02 -5.170258e-04 8.123476e-03
## UREA_T0 -2.173875e-02 -5.794882e-03 8.976738e-03 8.502152e-02
## HIERRO_T0 2.961958e-02 5.247408e-02 3.712242e-02 -5.932121e-02
## TRANSF_T0 -7.991814e-02 -5.297309e-04 2.331229e-02 1.893758e-02
## FERR_T0 5.594256e-02 -1.090745e-02 6.267454e-02 -4.431604e-02
## Ile_T0 3.395651e-03 2.304603e-02 -1.056735e-01 -5.987706e-03
## Leu_T0 4.970968e-02 1.821549e-02 -5.042700e-02 3.728352e-03
## Val_T0 1.689927e-02 7.532976e-03 -1.373951e-02 3.432954e-03
## Ala_T0 6.604340e-02 -1.660397e-02 -1.462294e-02 -7.373428e-02
## Pro_T0 2.782039e-02 2.401809e-02 -5.564526e-02 -8.057570e-02
## Gly_T0 -7.761953e-02 1.001663e-02 -4.639539e-02 -8.581869e-02
## Ser_T0 4.327584e-02 3.152186e-02 2.159147e-02 -9.804476e-04
## Trp_T0 5.787379e-02 -4.276533e-02 2.789210e-02 -3.060454e-02
## Phe_T0 1.104121e-01 -5.295521e-02 4.733975e-02 -5.226069e-02
## Met_T0 1.017366e-02 1.235856e-02 3.518358e-03 -2.189554e-02
## Orn_T0 3.822309e-02 7.602203e-02 -8.135143e-02 -7.536793e-02
## Arg_T0 5.557682e-02 -1.010432e-01 -2.845934e-02 2.310187e-02
## His_T0 1.729179e-02 7.682785e-02 -8.215211e-03 -1.002662e-01
## Asn_T0 6.900797e-02 -4.080765e-03 1.872903e-02 -9.923161e-02
## Asp_T0 2.955212e-02 -2.622420e-02 7.966970e-02 4.054407e-03
## Glu_T0 8.262029e-04 1.876110e-02 2.118263e-02 3.193098e-02
## Gln_T0 2.306887e-02 8.280404e-02 -2.659546e-02 -2.212773e-02
## Cit_T0 1.516162e-02 -4.609605e-03 -1.118956e-02 -9.433486e-02
## Tyr_T0 1.334120e-01 2.554741e-02 -8.618099e-03 -2.198119e-02
## Thr_T0 5.929230e-02 2.291329e-03 -7.200678e-02 -1.115989e-01
## Lys_T0 -2.549142e-02 7.789991e-02 -8.820467e-02 -3.072685e-02
## Creatinine_T0 4.430811e-02 2.129597e-02 2.456332e-02 7.690757e-02
## Kynurenine_T0 4.820368e-02 -1.745607e-02 -7.128262e-03 -9.945709e-03
## Putrescine_T0 -5.399463e-02 -4.691128e-02 -4.334442e-02 -1.598777e-01
## Sarcosine_T0 -3.221132e-02 -1.483003e-02 -6.538133e-02 -1.935448e-03
## Serotonin_T0 2.765412e-02 7.205205e-02 5.319443e-02 2.049851e-01
## Taurine_T0 1.106887e-01 -1.746091e-02 1.196136e-01 7.765279e-02
## SDMA_T0 4.754986e-04 1.150961e-02 1.620961e-03 1.148604e-02
## C0_T0 6.460713e-02 5.096983e-02 -3.309087e-02 2.727628e-02
## C2_T0 5.490867e-02 -1.735666e-02 2.675310e-02 1.209811e-01
## C3.OH_T0 -5.406346e-03 5.587244e-03 -1.006682e-03 3.914717e-03
## C6..C4.1.DC._T0 -9.276023e-02 1.412857e-01 3.276223e-02 7.502015e-02
## C5.DC..C6.OH._T0 -6.901117e-02 4.098150e-03 -4.340927e-02 3.198907e-05
## C7.DC_T0 1.324376e-02 1.223507e-02 -3.577122e-02 6.131771e-03
## C8_T0 -2.520103e-03 7.881745e-03 -1.888201e-03 1.711657e-03
## C10_T0 -5.753430e-03 7.091076e-03 3.869226e-03 1.271581e-03
## C10.1_T0 -3.997122e-03 6.021989e-03 6.406460e-04 1.358133e-03
## C10.2_T0 -6.456550e-03 5.168369e-03 -1.310472e-03 2.398501e-03
## C14.1_T0 -4.023852e-03 3.409407e-03 1.485420e-03 5.268622e-03
## C14.2_T0 -4.873070e-03 5.433458e-03 -2.455833e-04 3.842981e-03
## C16.1_T0 -5.090879e-03 4.325183e-03 -1.168654e-03 4.216949e-03
## C16.2_T0 -5.202726e-03 4.690172e-03 -8.108974e-05 3.500349e-03
## C16.2.OH_T0 -5.809423e-03 4.475587e-03 -3.839762e-04 3.435325e-03
## C18.1_T0 -3.672698e-03 3.871774e-03 8.380528e-04 5.225071e-03
## C18.1.OH_T0 -5.716876e-03 4.665758e-03 -2.945549e-04 3.344407e-03
## C18.2_T0 -3.930321e-03 5.617024e-03 3.351362e-06 4.338852e-03
## lysoPC.a.C16.0_T0 -2.134343e-02 3.743800e-03 1.287191e-02 4.394119e-02
## lysoPC.a.C16.1_T0 7.748809e-04 -1.607392e-02 -2.014709e-03 2.299559e-02
## lysoPC.a.C17.0_T0 -5.403075e-03 -3.238671e-03 -2.266306e-03 9.910772e-03
## lysoPC.a.C18.0_T0 -2.629219e-02 -2.892140e-02 4.434385e-03 2.599563e-02
## lysoPC.a.C18.1_T0 -5.245793e-02 -6.163163e-02 1.398347e-02 2.378385e-02
## lysoPC.a.C18.2_T0 -5.820817e-02 -1.750238e-02 1.780834e-02 -4.250961e-02
## lysoPC.a.C20.3_T0 3.014886e-03 -4.147989e-02 4.142017e-03 2.705076e-02
## lysoPC.a.C20.4_T0 -6.945572e-02 -2.052838e-02 3.417776e-02 -1.561288e-02
## lysoPC.a.C24.0_T0 -6.845912e-03 7.686118e-03 8.344806e-04 4.087006e-03
## lysoPC.a.C26.0_T0 -5.847114e-02 2.904459e-02 -5.320172e-03 -4.019862e-03
## lysoPC.a.C26.1_T0 -1.254706e-02 -1.130307e-04 -3.521323e-03 7.100026e-04
## lysoPC.a.C28.0_T0 -1.060572e-02 -5.662747e-02 9.422890e-02 -6.844535e-02
## lysoPC.a.C28.1_T0 -7.672318e-03 -6.356979e-04 -3.711990e-03 6.269812e-03
## PC.aa.C24.0_T0 -1.616366e-01 3.171936e-02 -2.766906e-02 2.039084e-03
## PC.aa.C28.1_T0 -4.251611e-03 -2.388648e-03 3.239090e-03 2.383256e-02
## PC.aa.C30.0_T0 -4.221711e-02 1.394274e-02 1.109975e-02 1.417078e-02
## PC.aa.C32.0_T0 -3.458645e-02 1.723584e-02 -1.907953e-02 1.220014e-02
## PC.aa.C32.1_T0 -9.024864e-03 -1.422043e-03 1.615664e-02 3.592131e-02
## PC.aa.C32.3_T0 -6.091637e-03 4.037644e-03 -1.297045e-04 2.379098e-03
## PC.aa.C34.1_T0 -5.834127e-02 -7.706651e-02 8.000328e-03 1.309401e-02
## PC.aa.C34.2_T0 3.532217e-03 4.543362e-02 2.367754e-02 -3.303962e-02
## PC.aa.C34.3_T0 1.411124e-03 -1.656373e-02 -5.803398e-03 2.817519e-02
## PC.aa.C34.4_T0 -2.137011e-02 1.625245e-03 -1.324589e-03 4.838159e-04
## PC.aa.C36.0_T0 6.120939e-04 -4.485794e-03 -1.590091e-03 5.212269e-03
## PC.aa.C36.1_T0 -3.404000e-02 -1.057271e-01 -1.702225e-02 -4.045330e-03
## PC.aa.C36.2_T0 -1.377041e-02 -4.857371e-02 -1.621517e-02 -1.957323e-02
## PC.aa.C36.3_T0 2.668125e-02 -2.053750e-02 2.529809e-02 -1.546980e-02
## PC.aa.C36.4_T0 -9.370333e-02 3.446336e-02 4.108394e-02 -3.564227e-02
## PC.aa.C36.5_T0 -1.091772e-01 5.696176e-02 8.471169e-02 2.257125e-02
## PC.aa.C38.0_T0 8.306569e-03 -7.997263e-03 1.224780e-02 1.689547e-02
## PC.aa.C38.1_T0 3.698873e-02 -5.059621e-02 -4.378150e-02 7.533228e-03
## PC.aa.C38.3_T0 3.507486e-02 -8.082852e-02 -2.706213e-02 1.343877e-02
## PC.aa.C38.4_T0 -5.948573e-02 6.825259e-03 2.574987e-03 -4.958849e-02
## PC.aa.C38.5_T0 -8.545998e-02 8.934315e-03 7.762100e-03 -2.279510e-02
## PC.aa.C38.6_T0 -1.800701e-02 5.550767e-02 4.138029e-02 8.583107e-02
## PC.aa.C40.1_T0 7.125208e-02 -9.475528e-03 1.413530e-01 -8.927423e-04
## PC.aa.C40.2_T0 -2.243557e-03 -2.544980e-03 -4.242697e-03 9.587743e-04
## PC.aa.C40.3_T0 -2.858170e-03 -2.753460e-03 -1.133894e-02 6.168490e-03
## PC.aa.C40.4_T0 -3.836378e-03 -3.538479e-03 -2.879267e-02 -7.240184e-03
## PC.aa.C40.5_T0 5.716488e-03 -7.146566e-03 -4.987869e-02 -9.341846e-03
## PC.aa.C40.6_T0 -9.390358e-04 3.942724e-02 -2.390936e-02 7.186921e-02
## PC.aa.C42.0_T0 -2.490441e-03 2.638444e-03 -1.898260e-03 3.173319e-03
## PC.aa.C42.1_T0 -4.493872e-03 4.150011e-03 -2.722040e-03 5.043364e-03
## PC.aa.C42.2_T0 -4.879546e-03 5.173603e-03 -4.529910e-03 5.944500e-03
## PC.aa.C42.4_T0 -4.888651e-03 2.033107e-03 -3.411676e-03 2.861894e-03
## PC.aa.C42.5_T0 -4.674271e-03 3.802810e-03 -3.034824e-03 2.211064e-03
## PC.aa.C42.6_T0 -9.904419e-03 5.463189e-02 5.569172e-02 -1.512833e-02
## PC.ae.C30.0_T0 -6.533212e-03 5.949881e-03 1.286286e-03 4.533220e-03
## PC.ae.C32.1_T0 9.652063e-04 -5.016575e-04 -1.101362e-03 -4.312423e-03
## PC.ae.C32.2_T0 -5.094422e-03 2.769860e-04 -3.885245e-03 2.635403e-03
## PC.ae.C34.0_T0 -4.996940e-03 4.864672e-03 -3.256860e-03 2.824093e-03
## PC.ae.C34.1_T0 1.545725e-02 -3.402509e-02 8.286210e-03 1.472431e-02
## PC.ae.C34.2_T0 2.846537e-02 -5.585550e-02 -1.590988e-02 6.477958e-03
## PC.ae.C34.3_T0 1.427904e-02 -2.568299e-02 -4.437586e-03 1.485059e-02
## PC.ae.C36.0_T0 -8.351106e-04 2.626941e-04 -3.351730e-03 6.177560e-03
## PC.ae.C36.1_T0 3.759408e-03 -1.513598e-02 -8.792128e-03 6.726114e-03
## PC.ae.C36.2_T0 1.609175e-02 -1.773599e-02 -1.920867e-02 -6.683460e-03
## PC.ae.C36.3_T0 3.974742e-02 -5.654343e-02 -3.367762e-03 1.273893e-02
## PC.ae.C36.4_T0 1.123678e-02 -9.162782e-02 -8.883070e-03 -4.011241e-02
## PC.ae.C36.5_T0 -6.764726e-03 -4.319059e-02 -1.093138e-02 -6.057921e-02
## PC.ae.C38.0_T0 -1.031633e-02 5.048450e-03 5.396925e-03 7.627883e-03
## PC.ae.C38.2_T0 6.374635e-04 -7.358313e-03 -1.083271e-02 -3.534681e-03
## PC.ae.C38.3_T0 1.302106e-02 -8.213513e-03 -7.831394e-03 8.138747e-03
## PC.ae.C38.4_T0 2.270922e-02 -1.504780e-02 -5.387053e-04 -4.755621e-02
## PC.ae.C38.5_T0 3.414178e-02 -9.235962e-02 -3.632915e-03 -2.321505e-02
## PC.ae.C38.6_T0 5.190681e-03 -2.565139e-02 1.423045e-02 1.095885e-02
## PC.ae.C40.1_T0 -1.706994e-02 1.042788e-03 -2.454399e-03 5.361070e-03
## PC.ae.C40.2_T0 7.114985e-03 -4.440692e-03 -1.306797e-03 7.998088e-03
## PC.ae.C40.3_T0 9.625826e-03 -2.033411e-03 -6.665684e-03 6.851542e-03
## PC.ae.C40.4_T0 7.898862e-03 5.767171e-04 -3.129890e-05 -5.692637e-03
## PC.ae.C40.5_T0 8.174889e-03 -4.023269e-03 6.415351e-04 -7.450802e-03
## PC.ae.C40.6_T0 4.309265e-03 3.084836e-03 2.410586e-04 9.360345e-03
## PC.ae.C42.1_T0 -5.042294e-03 2.054160e-04 -6.734174e-03 1.866176e-03
## PC.ae.C42.2_T0 -3.474823e-03 -3.885444e-04 -1.268969e-03 7.053560e-03
## PC.ae.C42.3_T0 -5.103258e-03 -3.846605e-04 -1.519939e-03 9.248121e-03
## PC.ae.C42.4_T0 3.024904e-03 -7.325530e-04 -8.973668e-04 1.550448e-03
## PC.ae.C42.5_T0 4.301815e-03 3.039509e-03 -5.654119e-05 1.290757e-04
## PC.ae.C44.3_T0 -5.622527e-03 1.575303e-03 -2.346358e-03 3.835481e-03
## PC.ae.C44.4_T0 5.504026e-04 1.195374e-03 -2.953591e-03 8.001748e-03
## PC.ae.C44.5_T0 1.109976e-02 -1.400341e-02 9.287683e-04 1.001067e-02
## PC.ae.C44.6_T0 -2.694147e-03 1.097528e-02 -3.462870e-04 6.250188e-03
## SM..OH..C14.1_T0 3.049254e-02 -1.929500e-02 -2.492272e-02 3.385236e-02
## SM..OH..C16.1_T0 9.609168e-03 -6.424030e-03 -7.719562e-03 1.469116e-02
## SM..OH..C22.1_T0 -2.189725e-03 -6.166216e-02 4.448778e-02 2.585237e-02
## SM..OH..C22.2_T0 1.534506e-02 -4.641121e-02 1.075477e-02 5.387071e-02
## SM..OH..C24.1_T0 2.775985e-03 2.395038e-04 4.298799e-03 9.593728e-03
## SM.C16.0_T0 -5.203024e-03 -9.967891e-02 -2.948147e-02 4.742703e-02
## SM.C16.1_T0 1.472698e-02 -9.321720e-02 1.694619e-02 6.101777e-02
## SM.C18.0_T0 6.433952e-03 -2.117095e-02 -2.293661e-02 5.613905e-02
## SM.C18.1_T0 7.330947e-03 -2.257162e-02 3.549909e-02 4.680275e-02
## SM.C20.2_T0 -5.169666e-03 3.252993e-03 -1.147687e-03 2.883341e-03
## SM.C24.0_T0 -1.892334e-02 -5.087931e-02 -3.612703e-03 2.275833e-02
## SM.C24.1_T0 2.550854e-02 -6.951043e-02 -2.658977e-02 8.235152e-02
## MEDDM_T2 -5.647053e-03 4.332562e-03 -2.164938e-04 2.939173e-03
## MEDCOL_T2 -5.647053e-03 4.332562e-03 -2.164938e-04 2.939173e-03
## MEDINF_T2 -1.914760e-02 5.161343e-03 -9.015937e-03 -2.859771e-03
## MEDHTA_T2 -1.374323e-02 2.906695e-03 -1.174204e-02 -1.585824e-03
## GLU_T2 2.716340e-02 7.064815e-02 -1.500781e-03 -3.103372e-02
## INS_T2 3.462670e-02 -3.144018e-02 9.185568e-02 -9.121508e-02
## HOMA_T2 1.678498e-02 -3.152628e-03 5.741918e-02 -6.409010e-02
## HBA1C_T2 -2.328997e-02 2.222714e-02 -1.939861e-03 1.540459e-02
## HBA1C.mmol.mol_T2 -3.863300e-02 4.307448e-02 2.088484e-03 3.021217e-02
## PESO_T2 2.508410e-02 -6.724665e-02 -1.335381e-02 5.441241e-03
## bmi_T2 7.033280e-02 -3.390832e-02 1.068669e-02 4.791537e-02
## CC_T2 -1.236467e-02 4.594047e-03 -1.133727e-03 4.983190e-03
## CINT_T2 -3.463027e-02 -3.057984e-02 3.643843e-03 3.719033e-02
## CAD_T2 3.331080e-02 4.362142e-03 2.656497e-02 4.213692e-02
## TAD_T2 4.071224e-02 2.379414e-02 8.893025e-02 -5.311398e-02
## TAS_T2 7.975247e-02 6.910725e-03 4.092092e-02 -3.077764e-02
## TG_T2 8.670518e-02 4.974422e-02 -6.410668e-02 7.821884e-02
## COL_T2 2.990573e-02 1.367541e-02 1.478802e-02 3.146150e-02
## LDL_T2 6.730292e-03 1.027524e-02 1.398044e-02 4.721617e-02
## HDL_T2 -3.118468e-02 -1.339647e-02 3.909516e-03 -6.517669e-02
## VLDL_T2 7.493219e-02 4.610652e-02 1.052768e-02 6.499330e-02
## PCR_T2 2.406686e-02 -2.421502e-02 9.946925e-02 -6.720439e-03
## LEP_T2 1.616393e-01 9.551618e-03 -1.233722e-01 -1.445196e-02
## ADIPO_T2 1.883187e-02 -9.581942e-02 -8.340251e-02 1.821099e-02
## GOT_T2 -6.366960e-03 2.122981e-02 9.091510e-02 -1.324892e-01
## GPT_T2 -1.274907e-01 -2.192959e-02 7.380633e-02 -2.806278e-02
## GGT_T2 -5.072136e-03 -1.183896e-02 -1.539996e-01 -6.822001e-03
## URICO_T2 4.046120e-02 7.532450e-02 3.697128e-02 4.437855e-03
## CREAT_T2 -2.379394e-03 1.880537e-03 2.211570e-03 6.283827e-03
## UREA_T2 1.191456e-01 9.253559e-02 -1.533211e-01 -2.664027e-02
## HIERRO_T2 1.330138e-01 1.130590e-01 1.312023e-01 1.464896e-02
## TRANSF_T2 -6.661902e-02 -6.682500e-03 -3.469919e-02 4.271203e-03
## FERR_T2 9.107312e-02 -5.547831e-04 -6.635881e-03 -6.193044e-02
## Ile_T2 1.079236e-02 3.396355e-02 1.211537e-03 3.260166e-02
## Leu_T2 1.005543e-02 4.809037e-02 -2.065583e-02 -2.038056e-02
## Val_T2 3.112768e-03 1.959982e-02 -2.584322e-02 -1.778443e-02
## Ala_T2 7.487821e-02 2.078153e-02 5.992179e-02 2.313938e-03
## Pro_T2 1.983822e-02 4.536243e-02 -2.447678e-03 -4.206498e-02
## Gly_T2 -1.104231e-01 2.892966e-03 6.525290e-03 1.366471e-02
## Ser_T2 -1.378367e-01 4.827872e-02 6.469087e-02 1.428006e-02
## Trp_T2 -3.534670e-02 -1.449500e-02 -8.599155e-03 1.979101e-02
## Phe_T2 -5.809973e-04 5.718736e-02 -4.945535e-03 -8.461445e-02
## Met_T2 2.540210e-02 -8.330509e-03 -2.929490e-02 -9.610980e-03
## Orn_T2 -6.273824e-02 3.297679e-02 1.408285e-02 1.880508e-02
## Arg_T2 -2.248062e-02 1.440731e-02 2.103565e-02 -2.601225e-02
## His_T2 -4.083747e-02 4.823196e-02 1.455390e-02 -6.076379e-02
## Asn_T2 -5.986992e-03 4.941951e-02 -3.641842e-02 7.609891e-03
## Asp_T2 3.030385e-02 -4.225531e-02 -4.954397e-02 1.741965e-02
## Glu_T2 3.456695e-02 3.337941e-02 4.270252e-02 2.877535e-02
## Gln_T2 -2.238406e-02 -1.814964e-02 5.409253e-02 5.942386e-02
## Cit_T2 3.279962e-02 1.581571e-02 -1.323972e-02 2.117800e-02
## Tyr_T2 2.871365e-02 8.094222e-02 4.212957e-02 -4.082473e-02
## Thr_T2 -8.997719e-03 9.399578e-02 5.469209e-02 -2.051561e-02
## Lys_T2 -5.244900e-02 3.757511e-02 5.362147e-03 -9.727781e-04
## Creatinine_T2 1.561004e-02 3.150553e-02 -4.469933e-02 -1.782099e-02
## Kynurenine_T2 1.108584e-02 3.536700e-03 -2.426323e-02 -1.672419e-02
## Putrescine_T2 6.885393e-02 4.070253e-02 1.384271e-01 4.673640e-02
## Sarcosine_T2 1.588803e-03 2.673061e-02 -2.657869e-02 7.388833e-02
## Serotonin_T2 -3.134583e-03 -8.759220e-02 -1.268502e-02 3.239083e-02
## Taurine_T2 1.049097e-02 -1.144086e-01 -1.228118e-02 3.825956e-02
## SDMA_T2 7.483506e-03 1.949727e-02 -6.483341e-03 -8.912980e-03
## C0_T2 -2.003742e-02 -3.725999e-02 -7.072928e-03 2.575559e-02
## C2_T2 -1.701185e-02 5.250649e-02 -8.090352e-03 4.638326e-02
## C3.OH_T2 -6.723606e-03 6.141254e-03 9.222234e-04 1.618005e-03
## C6..C4.1.DC._T2 -5.928673e-02 1.677235e-01 1.120311e-01 6.964081e-02
## C5.DC..C6.OH._T2 -4.724031e-02 -1.019853e-01 -1.598378e-02 -1.517626e-01
## C7.DC_T2 -2.765650e-02 -2.803394e-02 3.427247e-02 -7.477050e-02
## C8_T2 -5.728947e-03 7.073062e-03 3.643668e-03 -3.890490e-04
## C10_T2 -1.335346e-04 3.477713e-03 9.447104e-03 -4.596706e-03
## C10.1_T2 -4.593452e-03 5.727387e-03 1.931597e-03 6.075713e-04
## C10.2_T2 -6.749083e-03 4.539506e-03 7.573396e-04 3.233261e-03
## C14.1_T2 -9.325247e-04 5.447898e-03 3.656333e-03 2.913789e-03
## C14.2_T2 -3.266453e-03 6.481087e-03 1.404440e-03 2.836705e-03
## C16.1_T2 -3.734171e-03 5.429714e-03 3.100520e-05 3.399308e-03
## C16.2_T2 -5.139273e-03 4.754904e-03 7.624193e-04 3.385922e-03
## C16.2.OH_T2 -5.374274e-03 4.604203e-03 -2.227188e-05 3.019491e-03
## C18.1_T2 -3.765515e-03 4.571775e-03 2.847564e-03 2.673644e-03
## C18.1.OH_T2 -5.238710e-03 4.817083e-03 5.650617e-04 3.163231e-03
## C18.2_T2 -5.724921e-03 7.626283e-03 2.416288e-03 3.603615e-03
## lysoPC.a.C14.0_T2 4.804203e-02 -9.110435e-02 1.282267e-02 -1.760023e-03
## lysoPC.a.C16.0_T2 -1.944739e-02 -5.610710e-02 1.009667e-01 7.694070e-02
## lysoPC.a.C16.1_T2 2.888849e-02 -3.349453e-02 3.008299e-02 2.968252e-02
## lysoPC.a.C17.0_T2 -6.759379e-04 -7.276311e-03 2.603400e-04 1.889623e-02
## lysoPC.a.C18.0_T2 8.573847e-03 -4.714347e-02 6.141555e-02 4.642427e-02
## lysoPC.a.C18.1_T2 4.421627e-02 -8.246725e-02 8.119565e-02 4.354159e-02
## lysoPC.a.C18.2_T2 -6.127915e-03 -2.591090e-02 5.533266e-02 5.891621e-02
## lysoPC.a.C20.3_T2 2.142928e-02 -2.525092e-02 -2.134211e-03 9.152226e-03
## lysoPC.a.C20.4_T2 -1.886739e-02 -5.337222e-02 6.445766e-02 5.719489e-03
## lysoPC.a.C24.0_T2 -1.079554e-02 5.749952e-03 3.582219e-03 5.049893e-03
## lysoPC.a.C26.0_T2 -8.996303e-03 9.757192e-02 5.666218e-03 -6.695782e-02
## lysoPC.a.C26.1_T2 -9.990168e-03 4.113194e-03 6.749214e-03 5.122615e-03
## lysoPC.a.C28.0_T2 4.017201e-02 -3.522917e-02 4.442088e-02 6.764506e-02
## lysoPC.a.C28.1_T2 -7.603652e-03 4.470365e-03 6.742961e-03 1.853206e-03
## PC.aa.C24.0_T2 5.554916e-02 3.535899e-02 -2.892497e-02 -1.571072e-01
## PC.aa.C28.1_T2 -6.792857e-04 9.691182e-03 -1.583698e-03 1.382416e-02
## PC.aa.C30.0_T2 -8.791981e-03 7.566723e-03 -8.265771e-04 -1.250206e-02
## PC.aa.C32.0_T2 -3.800838e-02 -2.484743e-02 -4.105993e-03 -5.886669e-02
## PC.aa.C32.1_T2 3.752856e-02 -4.521059e-02 -3.298722e-02 1.793975e-02
## PC.aa.C32.3_T2 -6.445084e-03 4.359853e-03 -1.834523e-03 2.310004e-03
## PC.aa.C34.1_T2 3.258877e-02 -7.509129e-02 1.636045e-02 -2.041533e-03
## PC.aa.C34.2_T2 -5.022158e-03 2.925552e-02 -9.808112e-03 1.533776e-02
## PC.aa.C34.3_T2 1.793154e-02 -1.944263e-02 -5.021000e-02 3.208744e-02
## PC.aa.C34.4_T2 -2.895633e-03 2.738449e-03 -3.426609e-03 4.841654e-03
## PC.aa.C36.0_T2 -6.907551e-03 5.065437e-03 1.284010e-02 5.119886e-03
## PC.aa.C36.1_T2 1.140002e-02 -4.899864e-02 2.068607e-02 -1.224939e-02
## PC.aa.C36.2_T2 2.497729e-02 -1.778247e-02 6.393991e-03 7.080856e-03
## PC.aa.C36.3_T2 3.853570e-02 -3.476737e-02 -5.261683e-02 -2.071358e-02
## PC.aa.C36.4_T2 -6.683169e-02 -2.235015e-02 -1.004863e-02 -7.579776e-02
## PC.aa.C36.5_T2 6.838250e-02 3.982843e-03 -1.403392e-02 3.171266e-02
## PC.aa.C38.0_T2 5.989798e-03 -1.968162e-02 1.967961e-02 -2.148167e-03
## PC.aa.C38.1_T2 -1.201734e-02 3.444467e-03 4.367880e-03 6.239402e-02
## PC.aa.C38.3_T2 3.779344e-02 -4.547230e-02 -1.947005e-02 -1.445855e-02
## PC.aa.C38.4_T2 -1.715225e-02 -7.085962e-02 -1.845079e-02 -6.447090e-02
## PC.aa.C38.5_T2 2.916516e-02 -7.422598e-02 -4.308922e-02 -1.418022e-02
## PC.aa.C38.6_T2 -9.150250e-03 -6.287777e-02 -7.194321e-03 2.243587e-02
## PC.aa.C40.1_T2 -5.025455e-02 -3.007559e-03 -2.993545e-03 -6.814832e-02
## PC.aa.C40.2_T2 -1.091738e-02 7.083422e-03 1.200059e-02 -1.448739e-03
## PC.aa.C40.3_T2 -1.088373e-02 2.895125e-03 1.149036e-02 -2.472077e-04
## PC.aa.C40.4_T2 -1.419836e-02 -2.171985e-02 -9.682713e-03 -1.605446e-02
## PC.aa.C40.5_T2 5.690129e-03 -5.604116e-02 -2.263591e-02 -1.338214e-02
## PC.aa.C40.6_T2 9.359078e-03 -7.498030e-02 -5.580804e-03 3.622815e-02
## PC.aa.C42.0_T2 -4.434257e-03 -6.536096e-04 2.611072e-03 -4.636352e-03
## PC.aa.C42.1_T2 -6.706121e-03 3.194187e-03 2.673671e-03 -1.150074e-03
## PC.aa.C42.2_T2 -8.262254e-03 3.135930e-03 4.651893e-03 1.796301e-03
## PC.aa.C42.4_T2 -6.498891e-03 3.709008e-03 2.164396e-03 8.603802e-04
## PC.aa.C42.5_T2 -6.722100e-03 6.781413e-04 1.927441e-03 2.412219e-03
## PC.aa.C42.6_T2 6.993153e-02 -2.584284e-03 -6.940464e-02 -7.405866e-02
## PC.ae.C30.0_T2 1.382319e-01 5.071426e-02 -4.750294e-02 6.234329e-02
## PC.ae.C32.1_T2 2.999471e-03 5.808732e-03 -1.004281e-03 -1.884786e-02
## PC.ae.C32.2_T2 -4.823066e-03 -3.448834e-04 -5.328450e-04 1.478103e-03
## PC.ae.C34.0_T2 -4.597997e-03 6.485945e-03 -6.487735e-03 -1.587909e-03
## PC.ae.C34.1_T2 1.872385e-02 -1.521865e-02 5.834113e-03 -3.091390e-02
## PC.ae.C34.2_T2 6.975442e-03 -1.190303e-02 -3.395602e-03 -5.097485e-03
## PC.ae.C34.3_T2 -1.402924e-02 -9.662318e-03 1.237596e-03 1.332325e-02
## PC.ae.C36.0_T2 -6.995866e-03 -8.909829e-04 3.459556e-03 -2.224356e-03
## PC.ae.C36.1_T2 -5.541997e-03 5.239892e-03 2.453102e-02 -1.213874e-02
## PC.ae.C36.2_T2 1.251499e-02 6.103885e-03 -2.605660e-02 -2.357470e-03
## PC.ae.C36.3_T2 1.065060e-02 -6.031808e-03 8.649056e-03 -4.394099e-03
## PC.ae.C36.4_T2 8.137542e-03 -1.384398e-02 -3.157390e-03 -3.623133e-02
## PC.ae.C36.5_T2 3.188456e-03 -1.887045e-02 -2.079814e-03 -2.115953e-02
## PC.ae.C38.0_T2 2.736344e-03 -1.104218e-02 -6.084979e-03 1.424161e-02
## PC.ae.C38.2_T2 -1.443384e-02 7.702847e-03 2.640397e-02 -1.207711e-02
## PC.ae.C38.3_T2 -7.700341e-03 7.441143e-03 1.214162e-02 -1.283814e-02
## PC.ae.C38.4_T2 3.298992e-03 -1.418516e-02 -1.614363e-02 -3.864497e-02
## PC.ae.C38.5_T2 1.419973e-02 -3.483367e-02 2.003702e-02 -3.912264e-02
## PC.ae.C38.6_T2 1.750243e-03 -2.441967e-02 4.943319e-04 -1.132525e-02
## PC.ae.C40.1_T2 -1.259196e-02 2.162624e-04 1.119220e-02 7.522200e-03
## PC.ae.C40.2_T2 1.217117e-03 6.001922e-03 9.631739e-03 -4.553370e-03
## PC.ae.C40.3_T2 -1.094975e-02 6.588115e-03 1.836642e-02 -1.031902e-02
## PC.ae.C40.4_T2 -5.302424e-03 5.127576e-03 1.679691e-02 -1.372730e-02
## PC.ae.C40.5_T2 -3.852000e-03 -1.102239e-02 1.243155e-02 -1.722050e-02
## PC.ae.C40.6_T2 3.224532e-03 -8.090076e-03 -6.007182e-03 -5.383144e-03
## PC.ae.C42.1_T2 -9.316577e-03 5.651865e-03 5.444636e-03 -1.509460e-03
## PC.ae.C42.2_T2 -6.647905e-03 3.927427e-03 7.896672e-03 2.217682e-03
## PC.ae.C42.3_T2 -5.648440e-03 6.250042e-03 7.786561e-03 4.923425e-03
## PC.ae.C42.4_T2 -3.395588e-04 8.354888e-03 9.168212e-03 -5.723533e-03
## PC.ae.C42.5_T2 3.784640e-03 -1.138601e-02 2.090197e-02 -1.960646e-02
## PC.ae.C44.3_T2 2.072341e-02 -4.576393e-02 -6.356861e-02 5.396924e-03
## PC.ae.C44.4_T2 -4.920381e-03 5.433694e-03 2.089216e-03 1.833664e-03
## PC.ae.C44.5_T2 1.173774e-02 -1.191122e-02 1.455718e-02 -3.093515e-03
## PC.ae.C44.6_T2 -2.233828e-03 2.317780e-03 6.191623e-03 -3.434410e-03
## SM..OH..C14.1_T2 1.481211e-02 2.203863e-03 -4.398135e-04 -1.389084e-03
## SM..OH..C16.1_T2 8.859520e-03 5.012238e-03 -2.099675e-03 -7.379418e-03
## SM..OH..C22.1_T2 2.181656e-02 6.203827e-03 1.750249e-02 9.923480e-03
## SM..OH..C22.2_T2 1.768375e-02 3.489201e-03 1.275672e-02 -5.912787e-03
## SM..OH..C24.1_T2 -1.857330e-03 4.790593e-03 3.067397e-03 2.281870e-03
## SM.C16.0_T2 -6.366424e-03 -3.386829e-02 1.684031e-02 2.406161e-03
## SM.C16.1_T2 -1.639727e-02 -2.634012e-02 -4.344807e-04 -5.903990e-03
## SM.C18.0_T2 4.242775e-02 8.560488e-03 -2.673524e-03 -3.830637e-02
## SM.C18.1_T2 -7.260572e-03 -1.046593e-02 -9.008579e-03 -1.063372e-02
## SM.C20.2_T2 -6.517770e-03 3.846352e-03 5.755403e-05 5.949217e-04
## SM.C24.0_T2 1.315773e-02 1.478035e-03 3.247184e-02 2.164713e-02
## SM.C24.1_T2 3.786321e-02 -3.557987e-02 3.462546e-02 1.323666e-02
## MEDDM_T4 2.508434e-03 4.870160e-03 -4.776899e-03 2.677181e-03
## MEDCOL_T4 -1.384518e-02 1.225993e-02 1.322321e-03 3.109870e-03
## MEDINF_T4 -4.242920e-03 -8.359897e-03 -1.044165e-02 1.213151e-02
## MEDHTA_T4 -2.157971e-02 1.726334e-02 1.308972e-02 -7.248935e-03
## GLU_T4 -2.796766e-02 3.626081e-02 -3.187176e-02 -1.007246e-02
## INS_T4 -2.897064e-02 6.506788e-03 5.132772e-02 -6.639868e-02
## HOMA_T4 -1.326719e-02 7.525372e-03 1.366825e-02 -2.443525e-02
## HBA1C_T4 -1.997643e-02 2.748430e-02 -1.517388e-02 1.265312e-02
## HBA1C.mmol.mol_T4 -2.147223e-02 5.459895e-02 -4.292567e-02 1.655110e-02
## PESO_T4 2.301618e-02 -7.843506e-02 -2.520099e-02 7.751511e-03
## bmi_T4 6.432248e-02 -4.471862e-02 -3.767954e-03 4.777567e-02
## CC_T4 -1.253662e-02 1.879126e-02 -6.997433e-03 1.242675e-02
## CINT_T4 -5.362056e-02 -2.684733e-02 -7.185531e-03 3.165020e-02
## CAD_T4 2.014083e-02 -8.183955e-02 4.490191e-02 -1.929139e-02
## TAD_T4 3.610070e-02 3.786844e-02 8.902148e-03 -4.475886e-02
## TAS_T4 -5.910334e-03 5.994257e-02 4.121433e-02 -1.116807e-02
## TG_T4 -3.213873e-02 5.550445e-02 -8.396935e-02 2.319197e-02
## COL_T4 6.567734e-03 5.140433e-02 9.404397e-03 2.823289e-03
## LDL_T4 8.492874e-03 6.099565e-02 1.022495e-02 4.096304e-03
## HDL_T4 2.952112e-04 -1.711580e-02 2.950970e-02 -7.318850e-03
## VLDL_T4 -1.456424e-02 3.688473e-02 -1.405722e-02 -1.395398e-02
## PCR_T4 7.312830e-02 -1.042426e-01 -4.418798e-02 -3.752878e-02
## LEP_T4 1.599664e-01 7.029590e-02 -6.854348e-02 -6.437785e-03
## ADIPO_T4 1.877317e-02 -6.545773e-02 -7.842275e-02 2.602972e-02
## GOT_T4 -3.242940e-02 7.496264e-04 6.372312e-02 -1.592187e-03
## GPT_T4 -8.796385e-02 -1.567016e-02 5.696371e-02 8.241547e-02
## GGT_T4 1.027323e-02 7.945686e-02 -3.447359e-02 7.023728e-02
## URICO_T4 -4.813527e-03 1.965039e-02 -1.487337e-02 1.718731e-03
## CREAT_T4 -8.525386e-03 7.002448e-03 -7.570450e-03 3.753693e-03
## UREA_T4 5.385048e-02 1.110158e-02 -2.117312e-01 -3.046161e-02
## HIERRO_T4 1.181617e-01 3.963327e-02 -8.094247e-03 -9.731080e-02
## TRANSF_T4 -1.185584e-01 6.507996e-03 -1.984152e-02 9.846482e-03
## FERR_T4 5.774335e-02 -5.495662e-02 -8.044663e-03 -6.151897e-02
## Ile_T4 -1.967427e-04 -3.055432e-02 -8.360020e-02 2.498952e-02
## Leu_T4 2.257979e-02 -1.664303e-02 -7.917226e-02 -1.534312e-02
## Val_T4 -3.973642e-04 5.291291e-02 -6.404066e-02 -2.151953e-03
## Ala_T4 3.095796e-02 -3.535405e-02 -6.356472e-02 3.759823e-02
## Pro_T4 -1.164282e-03 8.968424e-02 -1.148549e-01 4.418561e-02
## Gly_T4 -6.912120e-02 -5.596814e-02 4.700065e-02 7.104190e-03
## Ser_T4 -8.443747e-02 6.608164e-02 -1.585138e-01 -2.560333e-02
## Trp_T4 -2.861821e-02 -3.808498e-03 2.848291e-02 -1.951224e-02
## Phe_T4 3.617479e-02 1.992278e-03 -5.594926e-02 -3.236459e-02
## Met_T4 -2.972295e-02 -4.308341e-03 -1.737468e-02 -1.067518e-02
## Orn_T4 -4.071618e-02 8.597385e-02 -1.042141e-02 1.203250e-01
## Arg_T4 -1.792825e-02 -6.547252e-02 -3.113070e-02 8.201527e-02
## His_T4 -8.187885e-03 -1.670941e-02 3.968147e-02 -3.124100e-02
## Asn_T4 1.042119e-02 -1.179582e-02 1.585498e-02 3.401079e-02
## Asp_T4 9.264415e-02 -1.268640e-01 -8.687490e-03 2.500465e-02
## Glu_T4 3.399174e-02 -2.201978e-02 3.663499e-02 6.316285e-02
## Gln_T4 -2.436204e-02 -4.475599e-02 -6.363202e-02 4.148409e-03
## Cit_T4 -3.161073e-03 4.811348e-02 3.952640e-02 7.604606e-02
## Tyr_T4 2.312036e-02 9.183821e-02 -8.943701e-02 6.007730e-02
## Thr_T4 2.387008e-02 1.617229e-02 5.117714e-02 2.464209e-02
## Lys_T4 -3.917993e-02 -1.886752e-01 8.332008e-02 -1.359798e-01
## Creatinine_T4 4.275386e-02 -8.285910e-02 5.566753e-02 4.498624e-02
## Kynurenine_T4 -1.644333e-01 -4.382565e-02 -6.412979e-02 -4.413363e-02
## Putrescine_T4 -7.301318e-02 -1.440920e-02 -6.166780e-03 -6.004165e-02
## Sarcosine_T4 5.367996e-02 -3.297248e-02 -6.715649e-03 -3.173486e-02
## Serotonin_T4 -1.119941e-02 -8.305339e-02 -2.816009e-03 3.067306e-02
## Taurine_T4 -5.143450e-04 -4.896481e-02 2.135425e-02 1.902580e-01
## SDMA_T4 6.813168e-03 7.647936e-04 5.812947e-03 1.030796e-02
## C0_T4 -5.733516e-02 7.925852e-02 -8.469695e-02 8.462246e-02
## C2_T4 2.083066e-02 -4.736085e-02 1.454934e-02 2.038693e-02
## C3.OH_T4 -8.187933e-03 5.291407e-03 -2.035788e-04 -3.216316e-04
## C6..C4.1.DC._T4 -5.332547e-02 3.281948e-02 7.952225e-02 -3.090727e-02
## C5.DC..C6.OH._T4 -2.404025e-02 -1.125975e-02 4.741985e-02 -5.950654e-03
## C7.DC_T4 7.170297e-02 -3.560200e-02 6.796280e-02 5.352362e-03
## C8_T4 -7.172460e-03 1.904332e-03 1.183668e-03 -4.948719e-03
## C10_T4 1.704737e-03 -1.765077e-03 6.622547e-03 -8.488984e-03
## C10.1_T4 -1.950357e-03 3.976535e-03 1.228558e-03 6.412111e-04
## C10.2_T4 -7.012335e-03 4.863610e-03 6.467764e-04 3.285210e-04
## C14.1_T4 -4.585043e-03 1.505333e-03 1.498130e-03 2.149498e-03
## C14.2_T4 -4.847810e-03 4.414798e-03 1.486645e-04 2.431060e-03
## C16.1_T4 -2.327870e-02 -6.239678e-03 8.153571e-02 -3.277827e-02
## C16.2_T4 -6.361499e-03 4.127998e-03 -7.578455e-04 2.908179e-03
## C16.2.OH_T4 -2.333395e-02 -5.653149e-03 8.100473e-02 -3.226099e-02
## C18.1_T4 -4.067647e-03 7.570343e-04 2.846456e-03 3.615752e-03
## C18.1.OH_T4 -6.119909e-03 4.188596e-03 -2.775104e-04 2.854606e-03
## C18.2_T4 -5.438666e-03 4.131768e-03 1.152314e-04 3.767473e-03
## lysoPC.a.C16.0_T4 -1.381257e-02 -7.097296e-03 2.784585e-02 4.963523e-02
## lysoPC.a.C16.1_T4 5.704631e-03 -2.719967e-02 -1.218288e-02 4.452730e-02
## lysoPC.a.C17.0_T4 2.675018e-03 2.626255e-02 9.364139e-04 1.623174e-02
## lysoPC.a.C18.0_T4 2.215515e-02 1.420911e-02 6.089263e-02 9.640186e-03
## lysoPC.a.C18.1_T4 -6.937168e-03 -1.902819e-02 5.327266e-02 1.473048e-02
## lysoPC.a.C18.2_T4 1.021252e-02 -9.080657e-03 7.605759e-03 5.059452e-02
## lysoPC.a.C20.3_T4 -2.608192e-02 -2.827310e-03 -2.717383e-02 2.028160e-02
## lysoPC.a.C20.4_T4 -3.601772e-02 -3.313640e-02 2.198117e-02 -2.255425e-02
## lysoPC.a.C24.0_T4 -1.021676e-02 8.409333e-03 -1.779476e-03 -2.444575e-04
## lysoPC.a.C26.0_T4 -9.304755e-02 -2.693065e-02 -2.794041e-02 7.476734e-02
## lysoPC.a.C26.1_T4 -1.453121e-02 4.484050e-03 -4.624069e-03 1.734890e-03
## lysoPC.a.C28.0_T4 6.154008e-02 2.038442e-03 -8.112585e-02 -8.188759e-02
## lysoPC.a.C28.1_T4 -1.014451e-02 7.388130e-03 -7.242066e-03 1.196955e-03
## PC.aa.C24.0_T4 -1.527911e-01 3.335566e-02 1.046086e-02 -3.122589e-02
## PC.aa.C28.1_T4 -7.254787e-03 8.014087e-03 -5.326452e-03 -1.496244e-04
## PC.aa.C30.0_T4 -2.019084e-02 1.208517e-03 -7.897741e-03 -1.104816e-02
## PC.aa.C32.0_T4 1.324747e-02 -2.092217e-03 2.884147e-02 -3.307938e-02
## PC.aa.C32.1_T4 2.803879e-02 -1.973467e-02 -4.958534e-02 2.664901e-02
## PC.aa.C32.3_T4 -5.085426e-03 3.905245e-03 -8.006566e-04 3.440716e-03
## PC.aa.C34.1_T4 -6.595726e-03 -9.846764e-04 2.508365e-02 4.610500e-03
## PC.aa.C34.2_T4 4.322501e-02 2.207347e-02 2.142425e-02 6.143162e-02
## PC.aa.C34.3_T4 -9.469286e-03 2.188451e-02 -4.364843e-02 8.648320e-02
## PC.aa.C34.4_T4 -9.660318e-03 8.820428e-03 -1.229211e-03 3.614071e-03
## PC.aa.C36.0_T4 -2.260315e-03 1.600287e-02 9.678507e-03 1.058111e-02
## PC.aa.C36.1_T4 1.601375e-03 1.509665e-02 6.619623e-02 -4.810951e-02
## PC.aa.C36.2_T4 4.442043e-02 2.028428e-02 6.110516e-02 4.318071e-02
## PC.aa.C36.3_T4 -2.944165e-02 3.323586e-02 7.603023e-03 2.493638e-02
## PC.aa.C36.4_T4 -3.854598e-02 3.684671e-02 1.195988e-02 -3.726904e-02
## PC.aa.C36.5_T4 -2.252797e-02 1.366816e-01 -3.385310e-02 1.277031e-02
## PC.aa.C38.0_T4 1.656264e-02 2.668836e-02 9.334643e-03 -1.000353e-02
## PC.aa.C38.1_T4 5.469469e-03 6.678147e-03 9.504219e-03 -1.046901e-02
## PC.aa.C38.3_T4 -1.976416e-02 1.584560e-02 -2.925924e-02 -3.538871e-02
## PC.aa.C38.4_T4 -1.994753e-02 3.774513e-02 2.486078e-02 -6.328470e-02
## PC.aa.C38.5_T4 -2.222147e-02 4.673839e-02 -1.821374e-02 -1.862563e-02
## PC.aa.C38.6_T4 -6.129141e-04 5.249354e-02 -1.021458e-02 -4.372803e-02
## PC.aa.C40.1_T4 7.152310e-02 -1.526180e-02 1.123455e-02 -2.216307e-02
## PC.aa.C40.2_T4 3.830389e-05 4.374812e-03 9.079790e-04 1.796629e-03
## PC.aa.C40.3_T4 -4.000145e-03 5.950825e-03 -2.612270e-03 3.100583e-03
## PC.aa.C40.4_T4 -6.871661e-03 -4.243698e-03 -9.323736e-03 -8.112658e-03
## PC.aa.C40.5_T4 -7.887108e-03 7.367724e-03 -3.048297e-03 -2.529517e-03
## PC.aa.C40.6_T4 1.632974e-02 2.024363e-02 4.194646e-03 -4.698708e-02
## PC.aa.C42.0_T4 -1.334421e-03 1.229716e-02 -3.190394e-03 2.897407e-03
## PC.aa.C42.1_T4 -3.369105e-03 5.858374e-03 -1.248847e-03 1.156329e-03
## PC.aa.C42.2_T4 -4.279150e-03 5.653893e-03 -4.599671e-04 6.683901e-04
## PC.aa.C42.4_T4 -2.639499e-03 2.986416e-03 1.471338e-04 1.565787e-03
## PC.aa.C42.5_T4 -5.535402e-03 4.098337e-03 8.503594e-04 6.685228e-04
## PC.aa.C42.6_T4 -8.652523e-02 -1.848144e-02 -2.349163e-02 4.991766e-02
## PC.ae.C30.0_T4 1.042870e-01 5.618084e-02 -4.831562e-02 1.944339e-02
## PC.ae.C32.1_T4 9.532226e-03 6.482226e-03 1.666047e-02 -4.195589e-03
## PC.ae.C32.2_T4 -6.461246e-04 7.661033e-03 -1.679511e-03 1.936868e-03
## PC.ae.C34.0_T4 -1.266336e-03 6.945387e-03 1.401022e-04 6.213203e-04
## PC.ae.C34.1_T4 3.060989e-02 2.108431e-03 3.531407e-02 9.101806e-03
## PC.ae.C34.2_T4 3.222867e-02 1.636585e-02 6.029575e-03 3.070680e-02
## PC.ae.C34.3_T4 4.114118e-02 -5.512996e-03 3.149864e-02 3.847484e-02
## PC.ae.C36.0_T4 -7.164558e-03 9.705851e-03 7.471223e-03 -1.510893e-03
## PC.ae.C36.1_T4 9.315830e-03 1.466162e-02 3.254249e-03 -1.747499e-02
## PC.ae.C36.2_T4 3.282826e-02 5.533273e-02 -8.756347e-03 3.053305e-02
## PC.ae.C36.3_T4 1.670650e-02 4.683757e-03 1.104073e-02 2.755198e-02
## PC.ae.C36.4_T4 3.937410e-02 1.033507e-02 3.148937e-02 -1.253070e-02
## PC.ae.C36.5_T4 2.110316e-02 3.050218e-02 2.678366e-02 -1.037593e-02
## PC.ae.C38.0_T4 -6.814011e-03 2.297505e-02 -9.929525e-03 1.003899e-02
## PC.ae.C38.2_T4 1.386379e-02 6.182628e-03 9.597137e-04 3.403381e-03
## PC.ae.C38.3_T4 1.007959e-02 4.716838e-03 -3.142989e-03 3.909301e-03
## PC.ae.C38.4_T4 2.710081e-02 2.273790e-02 2.304636e-02 -3.414765e-02
## PC.ae.C38.5_T4 3.239949e-02 -3.506096e-02 6.151785e-02 -3.199994e-02
## PC.ae.C38.6_T4 1.056011e-02 1.014550e-02 1.618036e-02 -1.835603e-04
## PC.ae.C40.1_T4 -6.809151e-03 1.987709e-02 -2.619125e-03 3.556002e-03
## PC.ae.C40.2_T4 1.182944e-02 3.943378e-03 9.352693e-03 -8.270877e-03
## PC.ae.C40.3_T4 1.516808e-02 4.206094e-03 -2.697602e-03 6.250806e-04
## PC.ae.C40.4_T4 1.535261e-02 1.204341e-02 1.332582e-02 -4.529246e-03
## PC.ae.C40.5_T4 1.733183e-02 -1.166012e-02 1.864294e-02 -2.016295e-02
## PC.ae.C40.6_T4 7.411119e-03 2.107496e-02 1.183315e-02 -7.537284e-03
## PC.ae.C42.1_T4 -3.183858e-03 5.574680e-03 -2.810018e-03 2.171316e-03
## PC.ae.C42.2_T4 -2.628540e-03 1.379839e-03 -3.671398e-03 6.641031e-03
## PC.ae.C42.3_T4 1.713493e-03 8.480083e-03 -9.635469e-04 6.874990e-03
## PC.ae.C42.4_T4 2.547868e-03 8.750867e-03 2.521791e-03 1.520830e-03
## PC.ae.C42.5_T4 1.431299e-02 9.628487e-03 2.046082e-02 -1.371107e-02
## PC.ae.C44.3_T4 -5.040785e-03 3.879295e-03 -1.109215e-03 3.013444e-03
## PC.ae.C44.4_T4 -2.511094e-03 5.028627e-03 1.429768e-03 5.044472e-03
## PC.ae.C44.5_T4 1.590095e-02 -1.198712e-03 1.811448e-02 5.095274e-03
## PC.ae.C44.6_T4 1.633537e-03 5.988863e-03 -3.108884e-04 -3.811170e-03
## SM..OH..C14.1_T4 4.231129e-02 1.390833e-02 3.690612e-03 1.083393e-02
## SM..OH..C16.1_T4 2.029405e-02 7.406794e-03 -4.347228e-03 -8.082512e-03
## SM..OH..C22.1_T4 2.166997e-02 -5.818154e-03 5.879100e-02 -1.076471e-02
## SM..OH..C22.2_T4 3.762161e-02 6.756919e-03 3.086037e-02 2.333675e-02
## SM..OH..C24.1_T4 -4.824727e-03 8.765468e-04 2.642172e-03 4.468085e-03
## SM.C16.0_T4 3.118398e-02 -7.024760e-02 2.560135e-02 -7.890368e-03
## SM.C16.1_T4 5.922895e-02 -6.245483e-02 3.200607e-02 1.488804e-02
## SM.C18.0_T4 1.354725e-02 -5.630575e-02 -6.798019e-02 -2.121373e-02
## SM.C18.1_T4 4.749996e-02 -5.452484e-02 -1.664905e-02 -3.437479e-03
## SM.C20.2_T4 -6.315210e-03 1.588522e-03 -1.886474e-03 3.572672e-03
## SM.C24.0_T4 2.042534e-02 -1.115038e-02 5.559609e-02 1.195155e-02
## SM.C24.1_T4 7.909938e-03 -5.400842e-02 -7.134715e-03 -1.175692e-02
## MEDDM_T5 -1.215140e-02 1.892288e-02 -3.713846e-03 1.173748e-02
## MEDCOL_T5 -1.215140e-02 1.892288e-02 -3.713846e-03 1.173748e-02
## MEDINF_T5 -1.024351e-02 5.471865e-03 -1.618744e-02 2.092101e-02
## MEDHTA_T5 -3.742653e-03 1.944652e-02 -8.403044e-03 1.144993e-02
## GLU_T5 -1.105012e-03 6.305845e-02 -4.705090e-02 2.030164e-02
## INS_T5 2.311529e-02 -1.783853e-02 3.730757e-02 -5.745260e-02
## HOMA_T5 8.139185e-03 9.690831e-04 1.085535e-02 -1.653347e-02
## HBA1C_T5 -2.982021e-02 2.207284e-02 -1.165776e-02 7.457689e-03
## HBA1C.mmol.mol_T5 -5.534167e-02 3.653455e-02 -3.134225e-02 -1.237305e-03
## PESO_T5 -1.817232e-02 -1.110993e-02 1.342098e-02 6.950555e-02
## bmi_T5 4.890168e-03 2.121263e-02 4.474003e-02 1.104184e-01
## CC_T5 -1.233951e-02 4.804718e-03 -4.954778e-04 3.110967e-03
## CINT_T5 -5.356064e-02 5.402418e-03 5.392996e-03 5.143261e-02
## CAD_T5 2.083178e-02 2.193120e-02 3.600915e-03 7.138528e-02
## TAD_T5 5.992323e-02 8.560809e-02 8.269473e-02 2.869023e-02
## TAS_T5 2.944324e-02 5.324271e-02 5.263534e-02 3.271713e-02
## TG_T5 -4.717724e-02 2.950024e-02 -1.883436e-02 -7.533243e-02
## COL_T5 1.430683e-02 4.252766e-02 -2.938254e-02 -3.616568e-02
## LDL_T5 1.714855e-02 3.789657e-02 -2.462774e-02 -9.887372e-03
## HDL_T5 -1.062221e-03 2.813056e-02 -1.603932e-02 -5.031757e-02
## VLDL_T5 5.987851e-03 -8.215912e-04 -1.856685e-02 -6.779953e-02
## PCR_T5 -1.650239e-02 5.461012e-02 6.661945e-02 -2.266853e-02
## LEP_T5 4.238692e-02 6.386480e-02 6.515016e-02 -2.185587e-02
## ADIPO_T5 -2.519766e-02 -3.980061e-02 -9.282826e-02 3.075407e-03
## GOT_T5 -2.448110e-03 1.391990e-02 -1.181854e-01 1.646274e-02
## GPT_T5 -4.018479e-02 -1.019588e-02 -6.806221e-02 1.026326e-01
## GGT_T5 2.161463e-02 1.888396e-02 -2.871833e-02 -1.335035e-03
## URICO_T5 -9.768863e-03 1.824812e-02 -1.615705e-02 2.845385e-03
## CREAT_T5 -3.451838e-03 6.670789e-03 1.313926e-03 3.035012e-03
## UREA_T5 3.352206e-02 3.464872e-03 -8.967631e-02 -7.332202e-03
## HIERRO_T5 1.067073e-01 1.567044e-01 3.471872e-03 -1.361022e-01
## TRANSF_T5 -7.245228e-02 -2.990592e-02 -5.825228e-02 1.148397e-02
## FERR_T5 -2.872008e-02 7.341960e-02 4.369494e-02 -5.849928e-02
## Ile_T5 -6.432331e-02 -9.845810e-02 4.098951e-03 -5.113138e-03
## Leu_T5 -1.403814e-02 -8.744255e-02 3.551757e-03 -2.428432e-02
## Val_T5 7.790214e-03 -5.304747e-02 -1.488802e-02 -4.205263e-03
## Ala_T5 1.899563e-02 -5.526083e-02 4.356429e-02 -5.344926e-02
## Pro_T5 -1.503003e-02 -4.487801e-03 2.713716e-02 -8.009313e-02
## Gly_T5 -3.729110e-02 -4.345035e-02 -3.080865e-02 -4.116782e-02
## Ser_T5 -5.395963e-02 -5.491676e-03 -6.311721e-02 -3.998163e-02
## Trp_T5 3.936330e-02 -5.985207e-02 -2.875734e-04 4.624235e-02
## Phe_T5 4.677485e-02 -5.685823e-02 1.565464e-02 -3.312902e-02
## Met_T5 -1.616842e-02 -5.262867e-02 5.239984e-02 -4.771190e-02
## Orn_T5 -2.997053e-02 1.000444e-04 -4.882588e-03 7.014798e-03
## Arg_T5 4.538897e-02 -2.707296e-02 2.587029e-02 5.464752e-02
## His_T5 -3.363089e-02 -5.977011e-03 3.833129e-02 -5.943247e-02
## Asn_T5 -2.219351e-02 -5.263356e-02 2.343692e-02 -2.100980e-02
## Asp_T5 2.316658e-02 -7.608379e-02 -8.197946e-02 -2.693028e-02
## Glu_T5 9.384528e-03 -4.537996e-04 2.113355e-02 7.318846e-03
## Gln_T5 3.939724e-03 -2.550476e-02 2.840303e-03 2.837727e-02
## Cit_T5 8.393797e-03 -5.780100e-02 6.112893e-02 6.693653e-02
## Tyr_T5 6.358557e-02 -3.101869e-02 2.743415e-02 3.236549e-02
## Thr_T5 4.611357e-02 -4.041097e-02 2.880014e-02 7.051668e-03
## Lys_T5 -1.322205e-02 -2.915154e-02 -1.863957e-02 6.309170e-03
## Creatinine_T5 -6.097603e-02 -6.075438e-02 1.074014e-03 6.575272e-02
## Kynurenine_T5 3.564197e-02 -3.829533e-02 -7.114218e-02 2.049746e-02
## Putrescine_T5 1.049769e-01 2.626105e-02 1.107551e-01 8.081849e-02
## Sarcosine_T5 3.171243e-02 -4.417270e-02 -2.204180e-03 7.980427e-02
## Serotonin_T5 2.828304e-02 -8.950605e-02 -7.971390e-03 5.175864e-02
## Taurine_T5 2.777413e-02 -1.840745e-03 -3.884006e-02 1.269154e-01
## SDMA_T5 3.295324e-03 4.765195e-03 1.060532e-03 8.285319e-03
## C0_T5 -5.129948e-03 2.687638e-02 1.566814e-02 6.273020e-02
## C2_T5 -1.399926e-02 3.684642e-02 -3.870773e-02 5.698967e-02
## C3.OH_T5 -8.185160e-03 2.287981e-03 -3.815484e-03 2.413609e-03
## C6..C4.1.DC._T5 -2.539170e-02 5.264564e-02 7.212189e-02 6.941495e-02
## C5.DC..C6.OH._T5 8.037170e-03 -4.335125e-02 -5.801437e-03 2.652536e-02
## C7.DC_T5 -6.864648e-02 -2.135950e-02 9.652906e-02 3.777382e-02
## C8_T5 -7.819134e-03 5.714559e-03 -2.060818e-03 2.918537e-03
## C10_T5 -1.783372e-03 9.576553e-03 1.480912e-03 3.162692e-03
## C10.1_T5 1.996965e-02 -9.972567e-03 -9.790865e-02 -4.026544e-03
## C10.2_T5 -6.468859e-03 4.203589e-03 -1.557475e-03 3.109347e-03
## C14.1_T5 -4.487179e-03 4.815074e-03 -7.424407e-05 3.491280e-03
## C14.2_T5 -6.114909e-03 4.378355e-03 -2.022769e-04 2.527573e-03
## C16.1_T5 -6.061560e-03 3.070626e-03 -1.014295e-03 3.104406e-03
## C16.2_T5 -5.834181e-03 4.175961e-03 -4.588976e-04 3.429980e-03
## C16.2.OH_T5 -9.009077e-02 -4.269014e-02 -9.499330e-02 1.088605e-02
## C18.1_T5 -5.042262e-03 4.332070e-03 -1.819053e-04 3.362380e-03
## C18.1.OH_T5 -5.533229e-03 4.192024e-03 -4.748739e-04 2.783911e-03
## C18.2_T5 -6.378266e-03 3.838254e-03 -4.259228e-04 3.456339e-03
## lysoPC.a.C16.0_T5 -3.873738e-02 -1.267373e-02 3.636362e-02 2.002333e-02
## lysoPC.a.C16.1_T5 -3.829708e-02 -3.255085e-02 3.019638e-02 1.018716e-02
## lysoPC.a.C17.0_T5 1.813623e-02 4.269653e-03 1.249543e-02 4.688479e-03
## lysoPC.a.C18.0_T5 2.519892e-02 4.294300e-03 6.018725e-02 1.564792e-02
## lysoPC.a.C18.1_T5 -3.352309e-02 -7.663331e-03 6.006357e-02 7.494720e-03
## lysoPC.a.C18.2_T5 -6.969217e-02 1.425284e-02 5.406400e-02 1.957501e-02
## lysoPC.a.C20.3_T5 -6.035783e-02 -1.120130e-02 1.248141e-02 2.121477e-03
## lysoPC.a.C20.4_T5 -1.390086e-01 -5.426873e-02 5.936057e-03 1.308377e-02
## lysoPC.a.C24.0_T5 -9.013414e-03 1.618317e-03 -1.914464e-03 5.110832e-03
## lysoPC.a.C26.0_T5 -8.604082e-03 -5.247227e-05 -6.533187e-04 1.271960e-03
## lysoPC.a.C26.1_T5 -1.212332e-02 -2.193522e-03 -1.586512e-03 2.009346e-03
## lysoPC.a.C28.0_T5 -9.389237e-02 -1.652437e-02 -4.007335e-02 2.500278e-02
## lysoPC.a.C28.1_T5 -9.621449e-03 3.591146e-03 -6.980944e-04 3.059061e-03
## PC.aa.C24.0_T5 7.412056e-02 -8.533977e-02 -9.176177e-02 6.572837e-02
## PC.aa.C28.1_T5 -3.021375e-05 -7.942036e-03 -5.581699e-03 -5.942852e-04
## PC.aa.C30.0_T5 6.823444e-03 1.034953e-02 1.382321e-02 -2.785525e-02
## PC.aa.C32.0_T5 9.272560e-03 2.793733e-02 7.116401e-03 -3.780354e-02
## PC.aa.C32.1_T5 1.032250e-02 6.585482e-03 3.863071e-02 -8.221348e-02
## PC.aa.C32.3_T5 -5.348563e-03 3.927045e-03 -1.237436e-03 2.320950e-03
## PC.aa.C34.1_T5 1.631738e-02 1.650260e-02 -4.742566e-03 -1.698106e-02
## PC.aa.C34.2_T5 2.900727e-02 4.888776e-02 2.756644e-02 -3.366856e-02
## PC.aa.C34.3_T5 2.768041e-02 -1.009231e-02 -6.720290e-03 -3.898531e-02
## PC.aa.C34.4_T5 -5.515969e-03 3.121036e-03 -1.070423e-03 -8.622692e-04
## PC.aa.C36.0_T5 1.403007e-02 1.343016e-03 -5.244533e-03 -4.124545e-03
## PC.aa.C36.1_T5 7.514059e-02 1.639929e-02 3.068525e-02 4.511941e-02
## PC.aa.C36.2_T5 7.088417e-02 3.404170e-02 3.572179e-02 6.064015e-04
## PC.aa.C36.3_T5 2.877815e-02 2.317888e-02 -7.970238e-03 -1.922684e-02
## PC.aa.C36.4_T5 -8.531380e-02 -3.443551e-02 -3.449996e-02 1.348940e-02
## PC.aa.C36.5_T5 3.016534e-02 -5.162969e-02 8.101686e-03 -5.365024e-02
## PC.aa.C38.0_T5 3.152916e-02 -7.652392e-03 4.823872e-03 -2.046743e-03
## PC.aa.C38.1_T5 -1.300652e-03 9.983090e-03 -1.157302e-02 4.707218e-03
## PC.aa.C38.3_T5 2.084485e-02 -1.286731e-03 6.398425e-03 -3.369665e-02
## PC.aa.C38.4_T5 -6.371574e-02 -2.953303e-02 -4.145715e-02 1.427516e-02
## PC.aa.C38.5_T5 -5.847056e-02 -4.283536e-02 -7.248366e-02 -2.696453e-03
## PC.aa.C38.6_T5 2.505914e-02 -4.025805e-02 -5.427639e-03 -1.480731e-03
## PC.aa.C40.1_T5 -1.431560e-02 4.613106e-02 -5.358810e-02 1.780685e-02
## PC.aa.C40.2_T5 -3.053985e-03 -6.410837e-06 1.219572e-03 1.843365e-03
## PC.aa.C40.3_T5 -6.582579e-03 -1.159644e-03 -1.346880e-03 -4.034917e-03
## PC.aa.C40.4_T5 -2.000199e-02 -3.906552e-03 -1.439995e-02 -1.733878e-02
## PC.aa.C40.5_T5 -2.767040e-02 -2.662283e-02 -2.307393e-02 -1.698011e-02
## PC.aa.C40.6_T5 9.338937e-03 -6.016125e-02 1.067868e-02 -1.528508e-02
## PC.aa.C42.0_T5 -1.892685e-03 3.082203e-03 -2.516186e-03 -2.762301e-03
## PC.aa.C42.1_T5 -4.384102e-03 3.577044e-03 -1.047590e-03 5.908845e-04
## PC.aa.C42.2_T5 -3.614694e-03 1.261895e-03 -2.016438e-04 -4.681893e-05
## PC.aa.C42.4_T5 -6.558825e-03 1.928285e-03 -1.543899e-03 -4.299503e-04
## PC.aa.C42.5_T5 -6.279784e-03 5.964528e-04 -2.905200e-03 -1.099878e-03
## PC.aa.C42.6_T5 1.787565e-02 -8.701089e-02 -7.682071e-02 -7.274189e-03
## PC.ae.C30.0_T5 1.887365e-02 -3.651824e-02 -5.833333e-02 2.271805e-03
## PC.ae.C32.1_T5 4.582441e-03 2.679035e-02 -1.138120e-03 -7.898968e-04
## PC.ae.C32.2_T5 -2.229861e-03 3.359177e-03 -3.393983e-03 3.597612e-03
## PC.ae.C34.0_T5 -1.050750e-03 5.655223e-03 1.198243e-05 -3.208524e-03
## PC.ae.C34.1_T5 5.799964e-02 1.636578e-02 2.454352e-02 -5.107226e-03
## PC.ae.C34.2_T5 5.498135e-02 5.875105e-02 2.595042e-03 1.988874e-02
## PC.ae.C34.3_T5 3.035519e-02 6.976189e-02 -2.198506e-03 1.523999e-02
## PC.ae.C36.0_T5 4.944732e-04 2.545093e-03 3.617524e-03 1.881442e-03
## PC.ae.C36.1_T5 4.446147e-02 -3.027289e-03 -5.544536e-04 -1.155167e-02
## PC.ae.C36.2_T5 7.878705e-02 3.654099e-02 1.087024e-02 2.739436e-03
## PC.ae.C36.3_T5 2.998245e-02 4.436523e-02 2.118648e-03 1.220342e-02
## PC.ae.C36.4_T5 2.768888e-02 2.310491e-02 -9.494884e-05 4.516457e-02
## PC.ae.C36.5_T5 5.805164e-03 3.130386e-02 -5.116751e-02 3.109121e-02
## PC.ae.C38.0_T5 2.992672e-03 -3.797577e-03 -1.095134e-03 1.182157e-03
## PC.ae.C38.2_T5 6.235138e-03 -3.101608e-03 7.646260e-03 -8.762313e-03
## PC.ae.C38.3_T5 1.409136e-02 3.016004e-03 -3.616922e-03 2.080159e-03
## PC.ae.C38.4_T5 2.257883e-02 1.808276e-02 2.651427e-03 3.044689e-03
## PC.ae.C38.5_T5 2.465686e-02 -2.224427e-02 -8.433865e-03 4.290491e-02
## PC.ae.C38.6_T5 1.823559e-02 -2.369599e-04 -1.421820e-02 3.224378e-02
## PC.ae.C40.1_T5 -6.062066e-03 -4.207754e-03 -7.103092e-03 1.067661e-02
## PC.ae.C40.2_T5 1.495444e-02 -9.340337e-03 -5.836347e-03 -6.487278e-03
## PC.ae.C40.3_T5 1.055723e-02 2.897995e-03 -3.760303e-03 7.175329e-04
## PC.ae.C40.4_T5 5.431572e-03 5.897197e-03 5.709263e-03 -1.004195e-02
## PC.ae.C40.5_T5 1.147169e-03 -5.932811e-03 -9.399763e-03 5.643133e-03
## PC.ae.C40.6_T5 1.865545e-02 -7.024796e-03 -7.460783e-03 4.931803e-03
## PC.ae.C42.1_T5 -7.160504e-03 7.010356e-04 -1.127678e-03 2.302273e-03
## PC.ae.C42.2_T5 -4.714585e-03 2.596480e-03 -2.220277e-03 2.844605e-03
## PC.ae.C42.3_T5 -1.067570e-03 4.420974e-03 2.848160e-03 2.488997e-03
## PC.ae.C42.4_T5 -2.459294e-03 6.652095e-03 3.177797e-03 -1.480182e-03
## PC.ae.C42.5_T5 2.726002e-03 4.451191e-03 6.000405e-03 -1.254294e-02
## PC.ae.C44.3_T5 -4.167404e-03 3.467226e-03 -7.311345e-04 1.155251e-03
## PC.ae.C44.4_T5 -3.205895e-03 7.818614e-03 -1.983892e-03 -5.643425e-04
## PC.ae.C44.5_T5 -5.797146e-03 -2.964582e-03 3.570962e-03 -1.008328e-04
## PC.ae.C44.6_T5 -1.366006e-02 4.769439e-03 -3.828909e-03 -4.180973e-03
## SM..OH..C14.1_T5 3.496955e-02 9.518628e-03 -2.781957e-02 6.342583e-03
## SM..OH..C16.1_T5 8.917218e-03 6.298961e-03 -9.878243e-03 2.909236e-03
## SM..OH..C22.1_T5 5.226469e-02 2.877245e-02 4.600481e-02 -1.965507e-02
## SM..OH..C22.2_T5 2.818473e-02 2.190884e-02 2.388689e-02 -8.266062e-03
## SM..OH..C24.1_T5 -5.870362e-03 6.001159e-03 3.661400e-03 1.247500e-03
## SM.C16.0_T5 -9.074720e-03 -6.234250e-03 -4.074202e-02 9.402622e-03
## SM.C16.1_T5 -2.062436e-02 -2.701496e-02 -2.036069e-02 9.722972e-02
## SM.C18.0_T5 -3.565447e-02 1.192970e-02 -6.371519e-02 -6.285627e-03
## SM.C18.1_T5 -5.534570e-02 1.813187e-02 -3.617685e-02 1.969706e-02
## SM.C20.2_T5 -8.726744e-03 3.942740e-03 3.411247e-04 1.871840e-03
## SM.C24.0_T5 4.271421e-02 3.158936e-03 6.182170e-02 -3.598210e-02
## SM.C24.1_T5 -3.069986e-02 -6.552131e-04 -4.247792e-02 -2.974281e-02
## PC25 PC26 PC27 PC28
## GLU_T0 -3.330054e-02 3.809685e-02 -5.984541e-03 -3.993760e-02
## INS_T0 4.845736e-02 3.918137e-02 -7.349649e-03 1.312606e-02
## HOMA_T0 2.657087e-02 2.609894e-02 -9.720048e-03 -5.593836e-03
## HBA1C_T0 7.925780e-03 2.225520e-03 2.287503e-04 2.099946e-03
## HBA1C.mmol.mol_T0 2.211683e-02 3.310134e-02 1.859428e-02 1.500561e-02
## PESO_T0 -3.366372e-03 -2.222508e-02 -1.148339e-02 -3.624408e-02
## bmi_T0 2.850679e-02 6.437569e-03 5.353911e-02 -9.553134e-03
## CC_T0 -2.031878e-03 1.135222e-03 2.148525e-03 -5.967980e-03
## CINT_T0 -9.995999e-03 -3.918056e-03 1.009256e-02 -5.026496e-02
## CAD_T0 3.062469e-03 -6.669389e-02 -5.635790e-03 4.681426e-03
## TAD_T0 1.835299e-03 -6.806184e-02 1.540754e-02 2.619026e-02
## TAS_T0 1.873608e-02 -3.735233e-02 -6.545144e-03 4.413566e-02
## TG_T0 -1.864583e-02 -1.512732e-02 5.442141e-02 -2.235447e-02
## COL_T0 8.942922e-02 -4.662701e-02 5.411291e-03 3.240192e-03
## LDL_T0 7.646534e-02 -6.012967e-02 2.614230e-02 1.144671e-02
## HDL_T0 4.986223e-02 -1.848923e-02 3.392558e-03 7.460098e-02
## VLDL_T0 -1.866767e-02 -1.608761e-02 5.540571e-02 -2.279264e-02
## PCR_T0 -1.822117e-02 8.651302e-02 1.710767e-01 1.377245e-01
## LEP_T0 -3.104812e-02 -1.978473e-03 -8.976349e-03 -5.305803e-02
## ADIPO_T0 -7.942763e-02 -4.593602e-02 -3.295254e-02 6.599733e-02
## GOT_T0 1.846781e-02 -1.642873e-02 1.202688e-02 -4.154410e-02
## GPT_T0 -4.416726e-02 -3.119580e-02 -7.318923e-02 -2.557512e-02
## GGT_T0 -9.718381e-02 -1.066398e-01 3.894927e-02 3.678129e-02
## URICO_T0 -1.679055e-02 2.774808e-03 2.814160e-02 -9.094829e-03
## CREAT_T0 -8.546869e-03 -9.927954e-03 -3.387069e-03 -4.283873e-03
## UREA_T0 7.286605e-02 7.420884e-03 -1.831310e-02 -5.237735e-02
## HIERRO_T0 -9.845866e-02 -6.588482e-02 -7.737152e-02 -1.222320e-03
## TRANSF_T0 2.503537e-02 -1.591491e-02 4.917946e-02 -9.232554e-02
## FERR_T0 5.969186e-02 -5.105256e-03 1.110999e-01 7.464203e-02
## Ile_T0 3.888989e-02 -1.279594e-02 -1.033675e-02 -8.097743e-03
## Leu_T0 4.355098e-02 -5.213360e-02 -2.113348e-02 1.867682e-02
## Val_T0 3.640352e-02 3.121451e-02 5.261240e-03 6.493416e-02
## Ala_T0 -2.350146e-02 -4.088889e-02 1.058294e-02 8.918158e-02
## Pro_T0 -3.497489e-02 -1.443069e-02 -3.943538e-02 -6.967149e-02
## Gly_T0 -1.553461e-01 4.658208e-02 -7.048778e-02 -3.682505e-02
## Ser_T0 -9.636958e-02 8.945607e-02 -9.808661e-02 1.006051e-01
## Trp_T0 -9.353378e-02 -2.741809e-02 -5.671870e-02 6.246888e-02
## Phe_T0 -2.103098e-02 7.107888e-03 -2.592687e-04 1.380308e-03
## Met_T0 -2.776063e-02 -2.648523e-02 -4.542412e-02 2.451612e-03
## Orn_T0 9.782356e-02 2.319961e-02 1.482175e-02 -7.467745e-02
## Arg_T0 -2.369518e-02 1.918694e-03 1.309650e-02 -6.402030e-02
## His_T0 -7.523202e-02 1.025048e-02 -5.418427e-02 -3.292692e-02
## Asn_T0 -8.069119e-02 -2.504625e-02 -4.917429e-02 -6.184984e-02
## Asp_T0 -2.016592e-03 4.370644e-02 -3.743410e-02 1.730055e-02
## Glu_T0 -2.147228e-02 1.592260e-02 4.553922e-03 3.391945e-02
## Gln_T0 -5.267490e-02 3.392320e-02 -4.507679e-02 -4.522152e-02
## Cit_T0 -2.410307e-02 4.633545e-02 -5.597435e-02 -1.121199e-01
## Tyr_T0 -3.462433e-03 -3.039762e-02 6.714476e-02 -2.955029e-02
## Thr_T0 4.963024e-02 1.830474e-02 -9.501448e-02 -3.041556e-02
## Lys_T0 -9.671786e-03 -2.851258e-02 3.521468e-02 -3.462360e-02
## Creatinine_T0 -1.445012e-01 -2.816963e-02 -8.940134e-03 -3.663187e-02
## Kynurenine_T0 -3.412793e-02 1.478782e-02 2.260526e-02 1.357466e-02
## Putrescine_T0 -3.661601e-02 2.462366e-01 -8.144857e-02 4.324627e-02
## Sarcosine_T0 2.914719e-02 3.819487e-02 4.334260e-02 -1.941869e-02
## Serotonin_T0 -1.355130e-01 5.443486e-03 1.045855e-01 1.982184e-01
## Taurine_T0 9.729396e-02 1.345444e-01 -1.202688e-01 2.562568e-02
## SDMA_T0 -1.058463e-02 -6.091790e-03 -1.807065e-03 -7.336744e-03
## C0_T0 -6.865593e-02 2.895294e-02 5.696480e-02 2.200393e-02
## C2_T0 -1.876082e-02 -7.247281e-02 -1.766367e-02 -2.032418e-02
## C3.OH_T0 8.934073e-04 -3.957710e-03 -9.741250e-04 -1.394909e-03
## C6..C4.1.DC._T0 7.094878e-03 1.365737e-02 4.642873e-02 8.072364e-02
## C5.DC..C6.OH._T0 1.063392e-01 1.259778e-01 3.184775e-02 -7.288365e-03
## C7.DC_T0 1.211704e-01 1.164593e-01 1.287695e-02 -2.836254e-02
## C8_T0 4.413582e-03 1.086296e-03 5.205319e-03 -3.425584e-03
## C10_T0 1.333799e-03 -1.162068e-02 2.382208e-03 -4.615143e-03
## C10.1_T0 2.422591e-03 -8.596753e-03 4.144417e-03 -1.766763e-03
## C10.2_T0 1.409969e-03 -4.396764e-03 2.982493e-03 -8.290319e-04
## C14.1_T0 5.049174e-05 -6.327317e-03 3.017323e-03 -3.725295e-03
## C14.2_T0 1.175555e-03 -5.371601e-03 2.721009e-03 -2.443442e-03
## C16.1_T0 1.107711e-03 -3.959504e-03 2.289520e-03 -2.178135e-03
## C16.2_T0 3.866039e-04 -5.003172e-03 2.687751e-03 -2.250161e-03
## C16.2.OH_T0 7.658804e-04 -5.002360e-03 2.562434e-03 -1.609395e-03
## C18.1_T0 -9.617001e-04 -4.615310e-03 3.873796e-03 -1.922777e-03
## C18.1.OH_T0 4.989377e-04 -5.075618e-03 2.426532e-03 -1.484552e-03
## C18.2_T0 -2.343982e-05 -4.721157e-03 3.129958e-03 -3.120903e-03
## lysoPC.a.C16.0_T0 -1.870301e-02 3.512434e-02 -4.592251e-02 6.317796e-03
## lysoPC.a.C16.1_T0 -1.845907e-03 1.253718e-02 -1.473056e-02 5.655034e-03
## lysoPC.a.C17.0_T0 -5.328167e-03 -1.175649e-02 -2.295085e-02 -2.126710e-03
## lysoPC.a.C18.0_T0 -8.469935e-03 2.961744e-02 -3.531389e-02 -6.344503e-04
## lysoPC.a.C18.1_T0 -4.198487e-02 1.059321e-02 -4.451378e-02 3.747749e-02
## lysoPC.a.C18.2_T0 -2.700846e-03 1.343363e-02 -6.794170e-02 3.422970e-02
## lysoPC.a.C20.3_T0 2.240033e-02 -1.443432e-02 -2.203777e-02 2.278857e-03
## lysoPC.a.C20.4_T0 -1.242449e-02 -3.301955e-02 -6.107513e-02 2.083692e-02
## lysoPC.a.C24.0_T0 5.069645e-03 -4.588508e-03 -4.381027e-04 4.569009e-04
## lysoPC.a.C26.0_T0 -5.217926e-02 -1.104135e-02 -3.125919e-02 2.632270e-02
## lysoPC.a.C26.1_T0 -1.365466e-03 -1.165172e-03 -1.519471e-03 2.352402e-03
## lysoPC.a.C28.0_T0 5.927951e-02 4.440307e-02 -8.144027e-03 3.673299e-02
## lysoPC.a.C28.1_T0 2.181103e-03 -1.939573e-03 2.882247e-03 -1.040130e-04
## PC.aa.C24.0_T0 -1.513975e-02 -4.692310e-02 -6.309735e-02 1.054152e-01
## PC.aa.C28.1_T0 2.942373e-02 5.112064e-03 -2.360315e-02 -1.526898e-02
## PC.aa.C30.0_T0 4.061275e-02 3.108154e-02 -2.692304e-02 -1.282818e-02
## PC.aa.C32.0_T0 4.492813e-03 5.545250e-02 -6.505378e-02 -5.699927e-03
## PC.aa.C32.1_T0 3.342163e-02 2.083617e-02 8.775351e-03 -1.208507e-02
## PC.aa.C32.3_T0 1.480180e-03 -4.124255e-03 2.872014e-03 -4.412433e-04
## PC.aa.C34.1_T0 -5.808964e-02 -1.563675e-02 -1.061359e-02 2.333182e-02
## PC.aa.C34.2_T0 1.436220e-02 8.398923e-03 2.274165e-03 -1.645876e-02
## PC.aa.C34.3_T0 2.110576e-02 2.382366e-02 5.674041e-03 1.595010e-03
## PC.aa.C34.4_T0 2.100460e-02 4.796933e-03 -5.396030e-03 -6.313318e-03
## PC.aa.C36.0_T0 4.743830e-03 -2.076239e-03 1.588252e-02 1.150201e-02
## PC.aa.C36.1_T0 4.192878e-03 -8.655264e-03 1.092506e-02 -7.219185e-03
## PC.aa.C36.2_T0 1.708872e-02 6.357398e-03 3.012547e-02 -2.905896e-02
## PC.aa.C36.3_T0 -1.491128e-02 2.087706e-02 -3.972879e-03 -3.247733e-02
## PC.aa.C36.4_T0 -2.808845e-02 -9.020701e-03 -4.243885e-02 -2.279725e-02
## PC.aa.C36.5_T0 4.519894e-03 -5.421899e-02 -2.089515e-02 1.958969e-02
## PC.aa.C38.0_T0 4.111184e-03 2.761207e-02 -8.255482e-03 4.794942e-02
## PC.aa.C38.1_T0 -3.258459e-02 -1.002271e-02 2.496111e-02 3.620296e-02
## PC.aa.C38.3_T0 1.021853e-02 4.669903e-03 -2.002377e-03 -1.546600e-02
## PC.aa.C38.4_T0 -3.104154e-02 -4.196877e-02 -2.067803e-02 -4.024057e-02
## PC.aa.C38.5_T0 -1.841474e-02 -5.399198e-02 -6.547889e-02 -2.717177e-02
## PC.aa.C38.6_T0 -5.467285e-02 -1.107600e-01 -8.499544e-02 3.308588e-02
## PC.aa.C40.1_T0 1.651679e-02 -3.315109e-02 -8.073915e-03 2.240687e-02
## PC.aa.C40.2_T0 4.605046e-03 6.181711e-03 1.539797e-02 -1.834220e-03
## PC.aa.C40.3_T0 3.138362e-03 1.247876e-03 1.524201e-02 1.204366e-03
## PC.aa.C40.4_T0 1.628764e-02 1.815537e-03 1.398212e-02 -2.671448e-02
## PC.aa.C40.5_T0 1.988256e-02 -1.882302e-02 2.354005e-02 -4.412979e-02
## PC.aa.C40.6_T0 -6.379228e-03 -9.945029e-02 -4.576195e-02 5.678932e-02
## PC.aa.C42.0_T0 1.975904e-03 2.193840e-03 -1.247909e-03 4.132466e-03
## PC.aa.C42.1_T0 2.127755e-03 -8.979214e-04 4.511503e-03 3.259690e-03
## PC.aa.C42.2_T0 2.073819e-03 2.233701e-03 9.120718e-03 2.492344e-03
## PC.aa.C42.4_T0 3.489023e-03 2.673122e-03 8.552888e-03 1.650155e-03
## PC.aa.C42.5_T0 -8.698651e-04 -2.165399e-03 6.494679e-03 -1.463061e-03
## PC.aa.C42.6_T0 -3.656740e-02 -3.595061e-02 -1.113042e-01 9.891552e-02
## PC.ae.C30.0_T0 4.361420e-03 -4.268271e-03 9.307923e-04 -6.630248e-04
## PC.ae.C32.1_T0 8.428638e-03 4.069566e-03 -1.763825e-02 3.389163e-03
## PC.ae.C32.2_T0 -9.036987e-05 -2.376690e-03 -2.446197e-03 1.694265e-03
## PC.ae.C34.0_T0 2.091888e-03 -4.031750e-03 3.882454e-03 2.583615e-03
## PC.ae.C34.1_T0 -1.436590e-02 6.716330e-03 -1.376056e-02 2.362471e-02
## PC.ae.C34.2_T0 -7.044878e-03 3.239347e-02 -9.283667e-03 2.487518e-02
## PC.ae.C34.3_T0 4.579224e-03 -1.257199e-02 2.503348e-02 4.864475e-04
## PC.ae.C36.0_T0 -5.001608e-03 -8.934826e-04 9.387882e-03 3.438685e-03
## PC.ae.C36.1_T0 3.424320e-03 1.659465e-03 2.479726e-02 3.904239e-03
## PC.ae.C36.2_T0 8.980820e-03 -1.105245e-02 9.893605e-03 1.191535e-02
## PC.ae.C36.3_T0 -2.692045e-02 2.660190e-02 2.003209e-04 2.137064e-02
## PC.ae.C36.4_T0 -2.297885e-02 7.366323e-02 1.605332e-02 2.567313e-02
## PC.ae.C36.5_T0 1.257403e-02 -6.861069e-03 1.974356e-02 -2.059912e-03
## PC.ae.C38.0_T0 8.322461e-04 -1.064627e-02 2.965298e-04 5.979182e-03
## PC.ae.C38.2_T0 1.288090e-02 1.864372e-02 2.850289e-02 -9.005732e-04
## PC.ae.C38.3_T0 2.071864e-03 -2.082762e-03 1.313521e-02 1.040205e-02
## PC.ae.C38.4_T0 -1.529690e-02 -1.348010e-03 -1.036695e-02 4.749441e-03
## PC.ae.C38.5_T0 -4.944449e-02 7.229523e-02 -1.899714e-02 5.327872e-02
## PC.ae.C38.6_T0 4.382384e-03 2.154078e-02 -2.081345e-02 2.281552e-02
## PC.ae.C40.1_T0 7.608788e-03 5.239730e-03 6.240455e-03 7.949047e-03
## PC.ae.C40.2_T0 9.562458e-03 -1.583930e-03 1.540024e-02 4.228771e-03
## PC.ae.C40.3_T0 6.331691e-03 3.914821e-03 1.367756e-02 7.911060e-03
## PC.ae.C40.4_T0 6.799696e-03 1.650369e-02 1.571506e-02 1.028256e-02
## PC.ae.C40.5_T0 5.587116e-03 1.633641e-02 1.077752e-02 8.605029e-03
## PC.ae.C40.6_T0 -1.517744e-03 -8.106331e-03 -2.548882e-02 1.862299e-02
## PC.ae.C42.1_T0 1.746463e-03 1.579200e-03 1.104234e-02 1.409377e-03
## PC.ae.C42.2_T0 3.982469e-03 -7.635549e-04 9.864865e-03 9.236661e-04
## PC.ae.C42.3_T0 7.482663e-03 1.789302e-03 1.102160e-02 2.302031e-03
## PC.ae.C42.4_T0 7.888267e-03 8.034372e-03 7.582853e-03 -1.912100e-04
## PC.ae.C42.5_T0 4.099723e-03 2.231904e-02 -3.976034e-03 1.299555e-02
## PC.ae.C44.3_T0 7.499331e-04 -1.865707e-04 6.727290e-03 -7.154628e-04
## PC.ae.C44.4_T0 2.535591e-03 -5.670317e-04 3.733760e-03 1.322408e-03
## PC.ae.C44.5_T0 2.072903e-04 1.308042e-02 -1.190590e-02 1.861736e-02
## PC.ae.C44.6_T0 -6.771930e-04 4.451195e-03 -8.436449e-03 1.028663e-02
## SM..OH..C14.1_T0 4.935202e-02 3.305772e-03 -1.755801e-02 -2.270471e-04
## SM..OH..C16.1_T0 1.038489e-02 -1.090486e-02 -5.374343e-03 -1.851818e-03
## SM..OH..C22.1_T0 4.949688e-02 -1.953625e-02 4.786934e-02 -2.299655e-02
## SM..OH..C22.2_T0 3.493459e-02 2.336677e-02 1.839277e-02 3.240324e-03
## SM..OH..C24.1_T0 3.643929e-03 -6.949653e-03 -9.435219e-04 -4.215584e-03
## SM.C16.0_T0 4.252676e-02 5.977779e-02 -3.214053e-02 3.056961e-02
## SM.C16.1_T0 1.178434e-02 3.428425e-02 -5.861956e-02 1.510777e-02
## SM.C18.0_T0 4.753968e-02 3.226785e-03 -4.484791e-02 1.845132e-02
## SM.C18.1_T0 -2.804140e-04 -1.466128e-02 -4.112668e-02 1.229994e-02
## SM.C20.2_T0 5.114063e-03 -9.438369e-04 1.446218e-03 -2.479887e-03
## SM.C24.0_T0 5.402258e-02 -9.818250e-03 4.902267e-02 2.082081e-03
## SM.C24.1_T0 1.097507e-02 5.687388e-02 -1.456455e-02 3.542257e-02
## MEDDM_T2 6.998534e-04 -4.836481e-03 3.235408e-03 -1.523158e-03
## MEDCOL_T2 6.998534e-04 -4.836481e-03 3.235408e-03 -1.523158e-03
## MEDINF_T2 1.394490e-02 2.103480e-04 1.348739e-02 -2.116349e-02
## MEDHTA_T2 2.368225e-03 -4.087830e-03 9.559456e-03 2.144600e-03
## GLU_T2 4.162062e-04 3.768484e-02 -5.173236e-02 5.507467e-02
## INS_T2 -5.090253e-05 -2.204381e-04 -1.695279e-01 3.650285e-02
## HOMA_T2 3.508930e-03 7.909645e-03 -1.075929e-01 2.906683e-02
## HBA1C_T2 5.689852e-03 -4.401258e-03 -1.856358e-02 -1.850236e-03
## HBA1C.mmol.mol_T2 2.094425e-02 1.696108e-02 -4.943232e-02 4.053430e-03
## PESO_T2 -1.202393e-02 -1.816431e-03 -3.082973e-02 -5.378427e-02
## bmi_T2 2.059910e-02 4.284446e-02 5.330095e-02 -3.066399e-02
## CC_T2 -1.419569e-03 -5.303957e-03 -3.802548e-04 -7.995151e-03
## CINT_T2 -3.233283e-03 1.724534e-02 -4.533327e-02 -8.378264e-02
## CAD_T2 1.967395e-02 -4.076300e-04 -2.660120e-02 -1.912732e-02
## TAD_T2 -1.430830e-02 1.151383e-02 6.497055e-02 -3.974195e-02
## TAS_T2 3.032212e-02 -2.667577e-02 3.848225e-02 1.184886e-02
## TG_T2 -1.622393e-03 -3.389280e-02 -9.138060e-02 -8.773202e-03
## COL_T2 -5.692757e-03 3.395374e-02 -1.272024e-03 2.418753e-02
## LDL_T2 -1.774196e-02 6.710270e-02 3.703686e-02 4.382402e-02
## HDL_T2 -1.974047e-02 -2.798570e-02 -5.138166e-02 4.607126e-02
## VLDL_T2 -3.777867e-02 1.005763e-02 -5.875104e-02 5.399645e-02
## PCR_T2 -2.691619e-02 1.193408e-01 8.454947e-02 1.812146e-01
## LEP_T2 1.003336e-03 -6.464399e-03 -5.423093e-02 -2.933910e-02
## ADIPO_T2 -2.962755e-02 -5.789072e-02 4.103032e-03 6.900283e-03
## GOT_T2 -1.348351e-02 -1.520924e-03 4.951287e-02 -1.645674e-01
## GPT_T2 -5.400541e-03 6.253057e-03 7.650758e-03 -3.211812e-02
## GGT_T2 -5.698567e-02 -1.388399e-01 4.971686e-02 9.377692e-03
## URICO_T2 5.922603e-02 -6.496633e-02 -9.312060e-03 3.787208e-02
## CREAT_T2 -2.983144e-03 -1.032551e-02 -5.117270e-05 -1.373610e-03
## UREA_T2 1.012490e-01 4.299118e-02 -3.553496e-02 -2.554139e-02
## HIERRO_T2 -1.148357e-01 -4.558793e-02 -4.215030e-03 -1.032257e-01
## TRANSF_T2 -4.039948e-02 2.561546e-02 2.452554e-02 -1.129316e-01
## FERR_T2 5.672556e-02 2.962909e-02 1.070536e-01 9.831528e-02
## Ile_T2 -9.277706e-03 -3.514753e-02 -2.090282e-03 1.556115e-02
## Leu_T2 -2.515499e-02 -4.751944e-03 -2.293138e-02 1.606344e-02
## Val_T2 -3.773886e-03 3.823318e-02 -3.534470e-02 -2.400145e-03
## Ala_T2 -1.944525e-03 -9.604644e-02 -9.411155e-02 4.474848e-02
## Pro_T2 5.627874e-02 -1.138931e-01 -9.639464e-02 -4.540719e-02
## Gly_T2 -6.124116e-03 -3.328652e-02 -5.763656e-02 2.661025e-02
## Ser_T2 2.042361e-02 1.332197e-02 1.744942e-02 1.339566e-01
## Trp_T2 -1.013802e-01 9.298686e-02 4.139280e-02 -1.402729e-02
## Phe_T2 -1.279818e-03 -1.717475e-02 -2.034441e-02 8.390415e-02
## Met_T2 6.683424e-02 -2.213170e-02 6.330154e-02 7.032882e-02
## Orn_T2 3.548677e-02 2.156503e-02 -1.427909e-02 -2.393250e-02
## Arg_T2 1.909496e-02 -8.069319e-03 4.658211e-02 -1.349586e-02
## His_T2 3.118064e-02 -9.614713e-03 -5.366835e-02 -2.761082e-03
## Asn_T2 3.265797e-02 -7.192697e-02 -4.223948e-02 -3.200968e-02
## Asp_T2 -2.971175e-02 -3.830532e-03 1.575607e-02 1.021018e-01
## Glu_T2 -3.085381e-02 -3.769164e-02 -2.887519e-02 4.030868e-02
## Gln_T2 7.800338e-02 -3.629995e-02 -2.719242e-03 -3.290286e-02
## Cit_T2 -2.031636e-02 2.810881e-02 -8.416384e-04 -4.709511e-02
## Tyr_T2 -1.251962e-02 9.146484e-03 -1.668865e-02 -3.500278e-03
## Thr_T2 6.507257e-02 4.436037e-02 -1.537285e-02 4.561494e-02
## Lys_T2 4.902485e-02 -5.835242e-02 -5.007756e-02 -2.434442e-02
## Creatinine_T2 1.094159e-02 -1.799225e-02 -2.907651e-02 6.644879e-02
## Kynurenine_T2 -5.309466e-03 1.908021e-02 2.959299e-02 -1.340452e-02
## Putrescine_T2 1.591330e-01 -4.163553e-03 -3.855072e-02 -8.753355e-02
## Sarcosine_T2 7.789150e-02 -8.442334e-02 -1.616977e-02 2.017387e-02
## Serotonin_T2 -5.781388e-02 1.954975e-02 -5.831070e-02 -6.417695e-02
## Taurine_T2 1.773786e-02 1.633644e-02 1.034508e-02 -3.843011e-03
## SDMA_T2 -4.518724e-03 -1.301404e-02 2.118971e-02 1.917940e-02
## C0_T2 -1.505898e-02 1.123809e-02 -1.327228e-02 -6.845577e-04
## C2_T2 9.496882e-02 -4.432794e-02 -2.722596e-02 5.017186e-02
## C3.OH_T2 -1.555335e-03 -3.075115e-03 5.953722e-03 5.882872e-04
## C6..C4.1.DC._T2 2.438482e-03 1.259964e-01 1.406865e-02 -7.629619e-02
## C5.DC..C6.OH._T2 4.568371e-04 -3.459540e-02 7.660597e-02 2.052815e-02
## C7.DC_T2 -5.015267e-02 8.898420e-02 9.115935e-02 1.214092e-02
## C8_T2 -2.397523e-03 -8.678811e-03 2.895251e-03 5.564288e-03
## C10_T2 -3.210234e-03 -9.246425e-03 -1.304516e-05 6.905900e-03
## C10.1_T2 -1.580838e-03 -9.464917e-03 3.261271e-03 2.162673e-03
## C10.2_T2 -5.446424e-04 -4.050147e-03 4.043942e-03 2.085832e-03
## C14.1_T2 1.163385e-03 -6.944509e-03 4.054226e-03 -8.209696e-04
## C14.2_T2 2.233051e-05 -5.812067e-03 2.269188e-03 3.135194e-04
## C16.1_T2 5.594039e-04 -6.167057e-03 3.595101e-03 -1.324978e-04
## C16.2_T2 5.646758e-04 -4.415496e-03 3.171602e-03 -1.307753e-03
## C16.2.OH_T2 4.407068e-04 -4.679345e-03 3.255912e-03 -9.166691e-04
## C18.1_T2 3.266645e-03 -7.203968e-03 5.622545e-03 1.198231e-03
## C18.1.OH_T2 3.463694e-04 -4.744781e-03 3.008169e-03 -6.917152e-04
## C18.2_T2 2.100470e-03 -6.853267e-03 4.145624e-03 1.738631e-03
## lysoPC.a.C14.0_T2 -7.865800e-03 6.986285e-02 -5.635120e-02 -1.024472e-01
## lysoPC.a.C16.0_T2 -1.776449e-02 7.564841e-02 -3.463363e-02 -6.406657e-02
## lysoPC.a.C16.1_T2 -1.344105e-02 2.978104e-02 -1.142903e-02 -1.465473e-02
## lysoPC.a.C17.0_T2 -2.101403e-02 6.864866e-03 -2.221256e-02 -2.421921e-02
## lysoPC.a.C18.0_T2 -5.463776e-02 5.913111e-02 -1.891964e-02 -4.778604e-02
## lysoPC.a.C18.1_T2 -3.718389e-02 6.551454e-02 -3.808418e-02 -2.452425e-02
## lysoPC.a.C18.2_T2 -7.540309e-02 2.401944e-02 -5.784078e-02 -2.407433e-02
## lysoPC.a.C20.3_T2 8.868036e-03 -2.105039e-04 -5.110575e-03 1.214995e-02
## lysoPC.a.C20.4_T2 5.242166e-02 -2.280628e-02 -6.068596e-02 -1.451184e-02
## lysoPC.a.C24.0_T2 -3.541675e-03 -4.868678e-03 -8.539904e-04 -3.753407e-03
## lysoPC.a.C26.0_T2 -1.165158e-02 -1.849652e-02 1.069871e-01 -1.121858e-01
## lysoPC.a.C26.1_T2 3.164357e-03 -8.268879e-03 7.857158e-03 -6.089077e-03
## lysoPC.a.C28.0_T2 -8.425902e-02 -4.918792e-02 4.281451e-02 8.725376e-02
## lysoPC.a.C28.1_T2 -3.101720e-03 -4.912896e-03 -9.086597e-04 -9.272758e-03
## PC.aa.C24.0_T2 6.615407e-02 -7.542048e-02 4.662428e-02 1.794969e-02
## PC.aa.C28.1_T2 -9.578932e-03 2.053343e-03 -2.201411e-03 5.932682e-03
## PC.aa.C30.0_T2 5.146175e-03 -1.202302e-02 -4.125162e-03 1.098094e-03
## PC.aa.C32.0_T2 3.703221e-02 1.900813e-02 5.253314e-02 -4.437209e-02
## PC.aa.C32.1_T2 1.071991e-02 5.155102e-02 -1.257806e-02 -3.132313e-02
## PC.aa.C32.3_T2 3.437940e-03 -5.912304e-03 4.991191e-03 -2.744278e-03
## PC.aa.C34.1_T2 -4.991508e-03 5.919593e-02 4.472964e-02 -2.306195e-02
## PC.aa.C34.2_T2 1.033764e-02 2.293205e-02 7.574617e-02 4.315617e-03
## PC.aa.C34.3_T2 -2.341333e-02 1.508502e-02 3.939269e-03 -2.000927e-02
## PC.aa.C34.4_T2 -1.687908e-04 -5.885663e-03 6.491171e-04 -1.966997e-03
## PC.aa.C36.0_T2 -8.781772e-03 -1.081215e-02 -1.032287e-02 -1.350850e-02
## PC.aa.C36.1_T2 -8.473033e-02 4.057865e-02 2.725674e-03 1.171940e-02
## PC.aa.C36.2_T2 -4.183608e-02 5.899868e-03 3.513874e-02 -1.111677e-02
## PC.aa.C36.3_T2 -2.013500e-02 2.941428e-02 2.163019e-02 4.435400e-02
## PC.aa.C36.4_T2 1.290916e-01 -5.467540e-02 3.772775e-02 -1.388765e-02
## PC.aa.C36.5_T2 -3.037296e-02 3.579817e-02 -5.172052e-02 -3.448212e-02
## PC.aa.C38.0_T2 -3.341014e-02 1.947930e-02 -1.233495e-02 -5.572661e-03
## PC.aa.C38.1_T2 -8.246032e-03 1.598314e-02 -5.169707e-02 9.891511e-03
## PC.aa.C38.3_T2 1.088045e-02 1.824627e-02 3.047354e-02 1.814052e-02
## PC.aa.C38.4_T2 8.701720e-02 -7.577204e-03 1.712621e-02 -7.029014e-02
## PC.aa.C38.5_T2 3.927457e-02 4.817727e-02 1.289335e-02 -7.130332e-02
## PC.aa.C38.6_T2 3.078560e-04 4.597543e-02 4.889243e-03 -3.090124e-02
## PC.aa.C40.1_T2 -4.888288e-02 2.466799e-02 2.781324e-02 2.460397e-02
## PC.aa.C40.2_T2 -1.546601e-02 -4.422479e-03 -1.737390e-02 -1.698561e-02
## PC.aa.C40.3_T2 -9.429098e-03 -2.660978e-03 -1.435469e-02 -1.699187e-02
## PC.aa.C40.4_T2 3.720933e-04 1.133868e-02 -4.481289e-03 -2.197799e-02
## PC.aa.C40.5_T2 7.677037e-03 3.281838e-02 4.469446e-03 -5.184969e-02
## PC.aa.C40.6_T2 -2.383667e-02 3.393701e-02 -1.296864e-02 -2.938792e-02
## PC.aa.C42.0_T2 -4.071051e-03 -3.172661e-03 -2.399154e-03 -9.541374e-03
## PC.aa.C42.1_T2 -2.922460e-03 -1.423440e-03 -1.793647e-03 -6.657031e-03
## PC.aa.C42.2_T2 -4.673693e-03 -4.492740e-04 -3.529342e-03 -8.659363e-03
## PC.aa.C42.4_T2 -1.432236e-03 -3.643751e-03 -1.031940e-03 -5.816925e-03
## PC.aa.C42.5_T2 -1.878761e-03 -2.253900e-03 -1.079197e-04 -7.182319e-03
## PC.aa.C42.6_T2 -2.800234e-02 5.293228e-02 5.899719e-02 -4.630914e-02
## PC.ae.C30.0_T2 -8.224521e-02 -3.404002e-02 5.036798e-02 3.159408e-02
## PC.ae.C32.1_T2 -7.279932e-03 -2.881711e-03 8.059367e-03 -1.721769e-03
## PC.ae.C32.2_T2 -1.541029e-03 -8.007441e-04 4.060182e-03 -5.944006e-03
## PC.ae.C34.0_T2 -2.071206e-03 -3.019915e-03 5.414778e-03 4.548138e-04
## PC.ae.C34.1_T2 -2.319864e-02 7.287006e-03 4.202390e-03 2.333605e-02
## PC.ae.C34.2_T2 -1.348874e-02 1.026655e-02 1.052127e-02 6.598739e-03
## PC.ae.C34.3_T2 -1.266869e-02 -2.521473e-02 1.551308e-02 -2.024701e-02
## PC.ae.C36.0_T2 -1.050255e-02 2.153468e-03 6.727401e-03 -6.666185e-03
## PC.ae.C36.1_T2 -5.081757e-02 5.112664e-03 -5.315768e-02 -3.790796e-02
## PC.ae.C36.2_T2 -3.522629e-02 2.422484e-04 -2.605162e-02 -3.562486e-03
## PC.ae.C36.3_T2 -9.165042e-03 7.182374e-03 8.823655e-03 1.146196e-02
## PC.ae.C36.4_T2 -3.158380e-03 1.199106e-02 2.357470e-02 -8.134691e-03
## PC.ae.C36.5_T2 1.697954e-02 8.548097e-03 1.976865e-02 -3.121207e-02
## PC.ae.C38.0_T2 -1.012734e-02 1.102249e-02 -1.334399e-03 -1.072611e-02
## PC.ae.C38.2_T2 -3.639771e-02 4.680880e-03 -4.619784e-02 -2.696280e-02
## PC.ae.C38.3_T2 -2.332690e-02 -5.058986e-03 -3.288476e-02 -2.045538e-02
## PC.ae.C38.4_T2 -4.654992e-03 -1.125958e-02 -7.223303e-03 2.708958e-02
## PC.ae.C38.5_T2 -1.797652e-03 -2.653740e-03 1.795799e-02 -8.813725e-03
## PC.ae.C38.6_T2 3.931314e-03 1.966757e-02 7.949014e-03 -1.460355e-02
## PC.ae.C40.1_T2 -1.745620e-02 -1.594973e-03 -1.282657e-02 -2.269313e-02
## PC.ae.C40.2_T2 -2.305664e-02 -4.695761e-03 -1.540794e-02 -8.529866e-04
## PC.ae.C40.3_T2 -2.152589e-02 -5.045298e-03 -2.334010e-02 -1.684616e-02
## PC.ae.C40.4_T2 -1.847106e-02 8.155691e-03 -7.144110e-03 -5.235712e-03
## PC.ae.C40.5_T2 6.397115e-03 1.793127e-03 -1.787770e-03 -1.154301e-02
## PC.ae.C40.6_T2 -5.680904e-03 1.166555e-03 -2.109518e-03 5.125290e-03
## PC.ae.C42.1_T2 -7.909593e-03 -7.146552e-03 -9.615536e-03 -1.556510e-02
## PC.ae.C42.2_T2 -1.194363e-02 -1.907025e-03 -8.541325e-03 -1.042020e-02
## PC.ae.C42.3_T2 -1.474416e-02 -1.584993e-03 -6.332825e-03 -1.255145e-02
## PC.ae.C42.4_T2 -7.025133e-03 -1.625929e-03 -2.702209e-03 5.677997e-03
## PC.ae.C42.5_T2 -5.001142e-03 6.188174e-04 2.071662e-04 -1.513416e-03
## PC.ae.C44.3_T2 -3.697745e-02 -8.366746e-03 2.186352e-02 3.920146e-02
## PC.ae.C44.4_T2 -3.069554e-03 -4.093503e-03 -1.042890e-03 -2.887303e-03
## PC.ae.C44.5_T2 -2.961117e-03 -1.179575e-02 -5.694363e-03 -7.892793e-03
## PC.ae.C44.6_T2 -4.674248e-03 -1.211823e-02 2.213640e-04 -4.215689e-03
## SM..OH..C14.1_T2 9.942621e-03 -9.932170e-03 -1.235504e-02 1.326694e-03
## SM..OH..C16.1_T2 4.626666e-03 -1.016903e-02 -6.696141e-03 4.300770e-03
## SM..OH..C22.1_T2 -1.904979e-02 7.464701e-03 2.658704e-03 -5.715427e-04
## SM..OH..C22.2_T2 -1.083230e-02 -7.005616e-03 -1.444536e-02 3.605460e-03
## SM..OH..C24.1_T2 -3.046617e-03 -5.490036e-03 9.187242e-04 -6.896580e-04
## SM.C16.0_T2 2.001695e-02 -1.509264e-02 -3.931704e-03 1.792236e-02
## SM.C16.1_T2 3.511162e-02 -2.720934e-02 6.797752e-03 1.468980e-03
## SM.C18.0_T2 7.730339e-02 -3.227226e-02 1.799971e-02 6.100133e-02
## SM.C18.1_T2 7.299691e-02 -4.046844e-02 2.280768e-02 1.914312e-02
## SM.C20.2_T2 4.827234e-03 -7.607502e-03 7.882929e-04 -3.049654e-04
## SM.C24.0_T2 -2.695671e-02 -1.398219e-02 -2.704923e-02 -8.847864e-03
## SM.C24.1_T2 1.970881e-02 -4.368514e-02 -4.657549e-02 4.106153e-02
## MEDDM_T4 -9.383916e-04 -1.229670e-02 -4.615668e-03 6.893428e-03
## MEDCOL_T4 -9.730286e-03 -2.979860e-03 7.672935e-03 -4.696380e-03
## MEDINF_T4 1.023270e-04 6.844283e-03 1.283825e-02 -1.439484e-02
## MEDHTA_T4 9.131447e-04 6.136403e-04 1.454952e-02 2.834590e-03
## GLU_T4 -4.230280e-02 3.472474e-03 -7.334732e-02 -8.510670e-02
## INS_T4 1.405955e-02 5.189941e-02 -2.137009e-02 5.043239e-02
## HOMA_T4 4.089748e-03 1.639104e-02 -1.597011e-02 5.567863e-03
## HBA1C_T4 1.009226e-02 -3.433935e-03 -7.202547e-03 6.970531e-03
## HBA1C.mmol.mol_T4 3.319927e-02 1.855462e-02 -4.060057e-03 3.359695e-02
## PESO_T4 9.668799e-04 -2.429384e-03 -3.941603e-02 -2.358927e-02
## bmi_T4 3.570487e-02 4.338217e-02 4.780044e-02 4.839325e-03
## CC_T4 -9.021067e-05 3.608555e-03 2.446192e-03 -1.298986e-03
## CINT_T4 -2.005571e-02 -7.282791e-03 1.666228e-02 -5.688193e-02
## CAD_T4 5.072528e-03 -6.976389e-02 -2.002414e-03 -3.464311e-02
## TAD_T4 -1.110884e-01 9.063517e-02 1.253132e-01 -9.307605e-02
## TAS_T4 -4.005693e-02 2.158012e-02 7.380090e-02 -9.937673e-02
## TG_T4 -6.054939e-02 -7.290611e-02 2.206064e-02 -3.568949e-02
## COL_T4 -1.878036e-02 3.202473e-02 -7.262518e-03 3.190474e-02
## LDL_T4 -2.910346e-02 5.395570e-02 2.796813e-03 4.737974e-02
## HDL_T4 3.593194e-02 -4.319409e-03 -6.075227e-02 6.199951e-02
## VLDL_T4 -2.925260e-02 3.499537e-02 4.499024e-02 -4.518061e-02
## PCR_T4 -6.115342e-02 5.938293e-02 9.857231e-02 1.634456e-01
## LEP_T4 5.781935e-02 1.234155e-01 3.550567e-02 -4.732903e-02
## ADIPO_T4 3.317430e-02 -5.764601e-02 8.820750e-03 -2.252433e-05
## GOT_T4 -1.468206e-01 3.994702e-02 6.191304e-02 -6.262857e-02
## GPT_T4 -1.483731e-01 2.891827e-02 4.959004e-02 -6.295915e-03
## GGT_T4 -1.634235e-01 -2.602860e-01 7.691349e-02 6.047146e-04
## URICO_T4 -2.855702e-02 -7.256085e-02 -1.207012e-03 1.406780e-02
## CREAT_T4 1.921042e-03 -1.006526e-02 -5.492213e-04 -4.638354e-03
## UREA_T4 1.196943e-01 1.144192e-01 -5.910676e-02 -1.411842e-02
## HIERRO_T4 -5.653604e-02 -1.350882e-01 -3.510620e-02 7.966195e-02
## TRANSF_T4 -7.658653e-02 4.094899e-02 1.895947e-02 -9.095033e-02
## FERR_T4 6.787866e-02 3.307919e-02 1.021986e-01 1.201265e-01
## Ile_T4 -3.834829e-02 4.286030e-02 5.967508e-02 2.445271e-02
## Leu_T4 -4.466059e-02 1.189065e-02 5.174837e-03 1.255840e-02
## Val_T4 -2.552049e-02 8.799074e-02 1.939998e-02 2.779421e-02
## Ala_T4 -4.377158e-02 -8.343212e-02 5.715076e-02 4.125949e-02
## Pro_T4 1.561728e-02 1.814744e-02 -1.298274e-02 2.919634e-02
## Gly_T4 -4.108831e-03 -3.786082e-02 3.665862e-02 -4.920889e-02
## Ser_T4 -5.747448e-02 1.074117e-01 -1.003808e-01 1.217544e-02
## Trp_T4 2.333362e-02 7.822499e-02 2.075418e-02 1.815257e-02
## Phe_T4 -4.153724e-03 4.564808e-02 -1.148696e-02 3.864889e-03
## Met_T4 7.686201e-03 7.384340e-03 3.566417e-02 -2.520378e-02
## Orn_T4 6.113002e-02 7.064832e-02 3.529851e-02 -3.556146e-02
## Arg_T4 7.691754e-02 1.025205e-02 6.633176e-02 -9.349149e-02
## His_T4 3.021023e-03 -4.476514e-02 2.998145e-02 -4.408814e-03
## Asn_T4 3.406581e-02 -6.931228e-02 5.043399e-02 -4.670981e-02
## Asp_T4 1.430667e-01 1.430784e-02 -7.715037e-02 1.100978e-02
## Glu_T4 -1.029465e-02 -3.798008e-02 -1.892969e-02 -4.940277e-05
## Gln_T4 1.303501e-02 -1.399487e-02 3.579324e-02 4.157040e-03
## Cit_T4 6.726162e-02 1.365730e-02 -2.376648e-03 -7.332045e-02
## Tyr_T4 3.501742e-02 6.445647e-02 6.777538e-02 3.260595e-02
## Thr_T4 5.396675e-02 1.084231e-02 6.380869e-02 1.436867e-03
## Lys_T4 3.920677e-02 -1.871605e-01 3.490895e-02 -6.313313e-02
## Creatinine_T4 -2.731410e-02 -3.632326e-02 -4.900159e-02 4.718515e-03
## Kynurenine_T4 2.610628e-02 1.073806e-02 8.529830e-02 8.493823e-02
## Putrescine_T4 1.267464e-01 -8.864619e-02 7.450930e-02 2.510479e-02
## Sarcosine_T4 2.947029e-03 -9.783575e-02 3.337760e-02 -9.399243e-02
## Serotonin_T4 -6.137454e-02 2.059712e-02 -4.389755e-02 -5.808980e-02
## Taurine_T4 1.115882e-01 4.436735e-02 2.684279e-02 -4.797747e-02
## SDMA_T4 -6.891292e-03 -9.818778e-03 -7.405098e-03 -6.699304e-03
## C0_T4 -1.184176e-02 6.709609e-02 2.603889e-02 7.600303e-02
## C2_T4 -4.842411e-02 -1.693020e-02 -1.592893e-02 2.899780e-02
## C3.OH_T4 -8.313507e-04 -3.705491e-03 6.617247e-03 5.317939e-04
## C6..C4.1.DC._T4 1.167860e-01 -3.380465e-02 -1.436952e-03 -4.274539e-02
## C5.DC..C6.OH._T4 -1.101545e-01 -2.912210e-02 1.514781e-01 4.006277e-02
## C7.DC_T4 -4.960860e-02 -3.710415e-02 8.280519e-02 8.373481e-02
## C8_T4 -7.666826e-03 -6.149456e-03 1.026761e-02 -7.813555e-05
## C10_T4 -1.391524e-02 -5.248685e-03 5.736083e-03 1.187533e-03
## C10.1_T4 -3.295575e-03 -5.040559e-03 6.311470e-03 -1.020862e-03
## C10.2_T4 -9.807131e-04 -5.217392e-03 5.061078e-03 -1.576417e-03
## C14.1_T4 -3.752931e-03 -5.811230e-03 6.870611e-03 -2.850205e-03
## C14.2_T4 -1.815230e-03 -6.652163e-03 5.270226e-03 -3.017464e-03
## C16.1_T4 -5.131663e-02 -1.880187e-02 9.457067e-02 -4.850139e-03
## C16.2_T4 -1.780196e-04 -4.830604e-03 4.930808e-03 -3.184577e-03
## C16.2.OH_T4 -5.056500e-02 -1.819532e-02 9.342047e-02 -4.950025e-03
## C18.1_T4 -2.173086e-03 -3.757112e-03 6.819669e-03 -5.149098e-03
## C18.1.OH_T4 -5.257854e-05 -4.634744e-03 4.448255e-03 -2.089146e-03
## C18.2_T4 -1.104606e-03 -4.991422e-03 5.617392e-03 -3.274856e-03
## lysoPC.a.C16.0_T4 5.016742e-02 1.580929e-02 -7.885658e-03 -7.172864e-02
## lysoPC.a.C16.1_T4 2.523188e-02 -3.149313e-02 2.464833e-02 -4.994494e-03
## lysoPC.a.C17.0_T4 3.319815e-02 -1.158616e-02 -3.288674e-02 -9.893439e-03
## lysoPC.a.C18.0_T4 4.864338e-02 -2.488886e-03 -4.380413e-02 -3.292454e-02
## lysoPC.a.C18.1_T4 -1.045681e-02 -5.209896e-02 -1.886991e-02 -4.731208e-02
## lysoPC.a.C18.2_T4 1.259878e-02 -9.104039e-03 5.455885e-02 8.582325e-03
## lysoPC.a.C20.3_T4 1.723562e-02 -3.133095e-02 -3.172765e-02 3.107050e-02
## lysoPC.a.C20.4_T4 2.060969e-02 -5.294693e-02 -1.141682e-02 -2.760723e-03
## lysoPC.a.C24.0_T4 -6.077428e-04 -7.584823e-03 3.889839e-03 -1.648267e-03
## lysoPC.a.C26.0_T4 4.782129e-02 -3.451355e-02 -7.515611e-04 3.828022e-02
## lysoPC.a.C26.1_T4 4.096243e-03 2.030318e-03 4.914165e-03 -9.789826e-03
## lysoPC.a.C28.0_T4 4.550749e-02 1.009990e-02 1.337834e-02 2.124657e-02
## lysoPC.a.C28.1_T4 5.645634e-03 -6.297471e-03 6.457816e-04 -1.524638e-03
## PC.aa.C24.0_T4 4.134529e-02 1.108169e-02 1.857120e-02 -1.183766e-01
## PC.aa.C28.1_T4 1.074155e-02 6.523430e-03 -3.928094e-03 -5.661503e-03
## PC.aa.C30.0_T4 -9.841760e-04 -9.880482e-03 1.051343e-02 -7.590681e-03
## PC.aa.C32.0_T4 -1.948407e-02 4.322656e-02 -1.154436e-02 -1.594762e-02
## PC.aa.C32.1_T4 -3.910904e-02 -8.690181e-02 4.681784e-02 3.716744e-02
## PC.aa.C32.3_T4 -7.848910e-04 -3.131392e-03 3.957162e-03 -1.282470e-03
## PC.aa.C34.1_T4 -4.630573e-02 -4.377719e-02 4.132795e-03 -1.926156e-03
## PC.aa.C34.2_T4 1.271898e-02 6.161323e-02 3.926346e-02 -1.655748e-02
## PC.aa.C34.3_T4 2.342860e-02 -1.438350e-03 5.343386e-02 4.292894e-02
## PC.aa.C34.4_T4 1.796357e-03 -4.361839e-03 2.650266e-03 2.184048e-03
## PC.aa.C36.0_T4 4.944963e-03 7.222419e-03 -1.158880e-02 1.315270e-02
## PC.aa.C36.1_T4 -7.435036e-02 -8.079194e-03 1.219066e-02 2.811268e-02
## PC.aa.C36.2_T4 -1.374854e-02 2.629006e-02 3.994852e-02 1.169537e-02
## PC.aa.C36.3_T4 -1.369219e-02 6.151696e-02 -3.290178e-02 5.603427e-02
## PC.aa.C36.4_T4 -1.890483e-02 2.946243e-02 -4.912054e-02 2.128071e-02
## PC.aa.C36.5_T4 -2.067302e-02 3.159903e-02 -8.090908e-02 8.375879e-03
## PC.aa.C38.0_T4 -1.827890e-02 3.160664e-02 -6.314143e-02 1.348623e-03
## PC.aa.C38.1_T4 3.278742e-03 3.073375e-02 -1.472787e-03 1.752902e-02
## PC.aa.C38.3_T4 -2.082771e-02 -2.319765e-02 -6.063594e-02 1.004762e-01
## PC.aa.C38.4_T4 -2.566292e-02 1.669630e-02 -6.353493e-02 2.511039e-02
## PC.aa.C38.5_T4 -2.913118e-03 1.577628e-02 -4.153936e-02 -2.665275e-02
## PC.aa.C38.6_T4 -3.214383e-02 1.284821e-02 -6.755953e-02 -1.582630e-03
## PC.aa.C40.1_T4 3.159923e-02 3.483436e-02 -7.944876e-02 8.770724e-02
## PC.aa.C40.2_T4 3.094742e-03 -3.851109e-03 5.346761e-04 4.458413e-03
## PC.aa.C40.3_T4 4.152626e-04 -5.747972e-03 4.330306e-04 5.429887e-03
## PC.aa.C40.4_T4 5.268347e-03 -8.469543e-03 -7.776729e-04 -2.534184e-04
## PC.aa.C40.5_T4 1.117381e-02 -2.989983e-03 -1.029204e-02 -6.598034e-03
## PC.aa.C40.6_T4 -2.604168e-02 -1.526610e-02 -7.747054e-02 3.477007e-02
## PC.aa.C42.0_T4 1.505914e-03 1.870588e-03 -6.787534e-03 1.995589e-03
## PC.aa.C42.1_T4 1.678036e-03 -2.067487e-03 -1.868049e-03 -4.016141e-04
## PC.aa.C42.2_T4 3.316763e-03 -3.470791e-03 1.880659e-03 -5.218368e-04
## PC.aa.C42.4_T4 2.978436e-03 -3.165559e-03 3.039246e-03 2.695011e-03
## PC.aa.C42.5_T4 -1.164182e-03 -3.275753e-03 3.871577e-03 1.024475e-03
## PC.aa.C42.6_T4 7.062070e-02 -1.301367e-02 -8.065531e-03 -3.810083e-02
## PC.ae.C30.0_T4 5.352201e-02 -3.281107e-02 5.236682e-02 -7.314665e-02
## PC.ae.C32.1_T4 1.260622e-02 7.969304e-03 -6.057103e-03 6.242640e-03
## PC.ae.C32.2_T4 5.360389e-04 1.115152e-04 -4.307824e-03 -2.824457e-03
## PC.ae.C34.0_T4 9.710077e-04 -5.656528e-03 -2.264797e-05 -6.722738e-04
## PC.ae.C34.1_T4 -3.843771e-04 3.469396e-02 -2.637429e-02 1.164089e-02
## PC.ae.C34.2_T4 2.858501e-02 2.584249e-02 -3.786854e-02 9.300457e-03
## PC.ae.C34.3_T4 3.782428e-02 -6.510348e-03 -2.147326e-02 4.133914e-03
## PC.ae.C36.0_T4 -5.331637e-03 -4.913188e-03 -5.961108e-03 -1.571630e-03
## PC.ae.C36.1_T4 2.819993e-02 1.566506e-02 -6.520191e-03 1.530766e-02
## PC.ae.C36.2_T4 3.806288e-02 1.633106e-02 -4.080112e-02 2.215273e-02
## PC.ae.C36.3_T4 1.726688e-03 1.418633e-02 -2.535516e-02 8.931628e-03
## PC.ae.C36.4_T4 -2.639770e-02 6.245655e-02 -3.638806e-02 -5.131865e-05
## PC.ae.C36.5_T4 8.152819e-03 4.775768e-02 -3.352536e-02 -1.572088e-02
## PC.ae.C38.0_T4 -3.381487e-03 -8.663793e-04 -2.097661e-03 7.651297e-03
## PC.ae.C38.2_T4 1.944896e-02 1.637801e-02 4.954651e-03 2.025038e-02
## PC.ae.C38.3_T4 1.081833e-02 7.500801e-03 -9.847179e-03 2.656284e-02
## PC.ae.C38.4_T4 1.338769e-03 4.686998e-02 -4.508668e-02 2.691895e-02
## PC.ae.C38.5_T4 -4.117669e-02 6.548312e-02 -3.499954e-02 -1.908475e-02
## PC.ae.C38.6_T4 -2.606845e-03 3.842872e-02 -3.756273e-02 -1.369255e-02
## PC.ae.C40.1_T4 7.435166e-03 3.798424e-03 -3.529576e-03 9.769995e-03
## PC.ae.C40.2_T4 1.619013e-03 -4.863446e-04 -1.183336e-02 4.985598e-03
## PC.ae.C40.3_T4 1.195453e-02 3.359884e-03 -1.029846e-03 1.832841e-02
## PC.ae.C40.4_T4 4.789127e-03 2.538489e-02 4.594510e-04 1.281591e-02
## PC.ae.C40.5_T4 3.031950e-03 3.193503e-02 3.610340e-04 -5.488736e-03
## PC.ae.C40.6_T4 5.489628e-03 1.709564e-02 -3.066611e-02 -1.733838e-03
## PC.ae.C42.1_T4 7.722434e-04 -6.559735e-03 -8.455351e-04 6.109259e-03
## PC.ae.C42.2_T4 4.914977e-04 -4.310613e-03 4.620055e-03 5.840536e-03
## PC.ae.C42.3_T4 7.730872e-03 4.777045e-03 4.223729e-03 -6.673728e-04
## PC.ae.C42.4_T4 9.210269e-05 5.132488e-03 4.142622e-03 5.237672e-03
## PC.ae.C42.5_T4 1.574754e-03 4.078942e-02 4.954544e-03 -2.098645e-02
## PC.ae.C44.3_T4 4.346605e-03 -4.699102e-03 2.899677e-03 5.440816e-04
## PC.ae.C44.4_T4 2.835871e-03 -3.828077e-03 4.062367e-03 -1.842915e-04
## PC.ae.C44.5_T4 2.358655e-03 1.601070e-02 2.015203e-02 -1.397428e-02
## PC.ae.C44.6_T4 7.711288e-03 1.035433e-02 3.169855e-03 -9.695337e-03
## SM..OH..C14.1_T4 3.955861e-02 -1.011091e-03 -1.695403e-02 -2.690587e-02
## SM..OH..C16.1_T4 8.735004e-03 -7.798223e-03 -1.059034e-02 -3.704249e-03
## SM..OH..C22.1_T4 1.023259e-02 1.367903e-02 2.772078e-02 -4.692367e-02
## SM..OH..C22.2_T4 1.796205e-02 2.664050e-03 -3.944362e-03 -4.876521e-02
## SM..OH..C24.1_T4 -2.086088e-03 -3.029050e-03 8.825109e-03 -9.989451e-03
## SM.C16.0_T4 -2.578615e-02 3.118929e-02 1.277430e-02 -6.126104e-02
## SM.C16.1_T4 -2.745173e-02 1.345921e-02 -3.986571e-03 -6.939342e-02
## SM.C18.0_T4 -7.575350e-03 1.919290e-03 4.852531e-02 2.003990e-03
## SM.C18.1_T4 -2.709565e-02 -2.462113e-02 3.613676e-02 -1.459797e-02
## SM.C20.2_T4 1.533681e-03 -4.924136e-03 5.628410e-03 -2.821648e-03
## SM.C24.0_T4 -3.749614e-02 -6.395831e-02 3.641547e-02 -4.116920e-02
## SM.C24.1_T4 -2.041251e-02 3.666487e-03 1.383720e-02 -6.288198e-02
## MEDDM_T5 -2.063251e-02 3.396545e-03 -2.399198e-03 -1.907715e-02
## MEDCOL_T5 -2.063251e-02 3.396545e-03 -2.399198e-03 -1.907715e-02
## MEDINF_T5 -2.259225e-02 1.481485e-02 7.415911e-03 -3.406658e-02
## MEDHTA_T5 -2.226526e-02 -4.316351e-03 -1.046747e-02 -1.036532e-02
## GLU_T5 -7.661183e-02 4.933121e-02 -6.004942e-02 3.761993e-02
## INS_T5 -4.286528e-02 1.031298e-01 1.044872e-02 7.359608e-02
## HOMA_T5 -1.538664e-02 4.253881e-02 -2.135297e-04 3.253889e-02
## HBA1C_T5 1.068110e-04 4.615063e-03 -2.098526e-02 -3.974273e-03
## HBA1C.mmol.mol_T5 -7.390671e-04 4.657042e-02 -5.135424e-02 -3.462753e-03
## PESO_T5 1.876216e-02 1.435659e-02 -5.357401e-02 -1.995277e-02
## bmi_T5 3.195703e-02 7.905974e-02 3.524438e-02 2.077902e-03
## CC_T5 -1.200656e-04 -4.713545e-03 1.602601e-03 -3.877849e-03
## CINT_T5 -7.842030e-04 -1.595128e-02 -4.584657e-04 -3.275649e-02
## CAD_T5 2.910551e-02 -2.555421e-02 -3.330191e-02 1.604723e-02
## TAD_T5 -1.569007e-02 -1.152572e-02 6.892586e-04 -2.465859e-02
## TAS_T5 4.896416e-02 -9.061131e-02 -4.668352e-02 3.338855e-02
## TG_T5 -2.835336e-02 5.734319e-02 1.016820e-01 -3.951411e-02
## COL_T5 1.396038e-02 2.372425e-02 5.896690e-02 -4.319608e-03
## LDL_T5 1.072550e-02 4.205204e-02 9.367430e-02 -1.085651e-03
## HDL_T5 5.382546e-02 -5.256011e-02 -8.863590e-02 4.859408e-02
## VLDL_T5 -1.285238e-03 5.615610e-02 6.952201e-02 -1.986953e-02
## PCR_T5 -1.940740e-03 7.789043e-02 3.165946e-02 5.105746e-02
## LEP_T5 4.019997e-02 2.832348e-02 6.343014e-02 -4.530587e-02
## ADIPO_T5 1.930971e-02 -4.702523e-02 -4.970920e-02 2.244974e-02
## GOT_T5 -1.016708e-01 6.063685e-02 1.366361e-02 -5.097217e-02
## GPT_T5 -6.529613e-02 1.531429e-01 -5.949180e-02 -2.734485e-02
## GGT_T5 -1.090856e-02 7.764638e-03 -5.273746e-03 -1.921061e-03
## URICO_T5 -7.979250e-03 -1.367467e-02 -1.400036e-02 -1.881807e-02
## CREAT_T5 1.182822e-03 -6.269518e-03 -7.686990e-03 -3.638811e-03
## UREA_T5 1.636254e-02 9.134357e-02 -3.737888e-02 -4.617264e-02
## HIERRO_T5 -5.948542e-02 8.226784e-02 1.042985e-01 -5.850895e-02
## TRANSF_T5 -4.448111e-02 -4.866008e-02 5.912047e-02 -1.178298e-01
## FERR_T5 1.375792e-01 4.168441e-02 3.058181e-02 7.400060e-02
## Ile_T5 -2.335521e-02 2.839629e-02 -6.359413e-02 -9.207185e-03
## Leu_T5 -9.262132e-03 4.261992e-02 -4.286999e-02 -9.051500e-03
## Val_T5 -1.846523e-02 7.233302e-02 1.472181e-02 1.845684e-02
## Ala_T5 -1.218757e-02 1.887469e-02 -2.686723e-02 4.309524e-02
## Pro_T5 4.368967e-02 6.670884e-03 -3.318052e-02 1.146798e-02
## Gly_T5 -5.075802e-02 5.202009e-03 -3.191000e-02 1.356819e-02
## Ser_T5 -6.126752e-02 -6.603536e-03 3.274839e-02 3.959551e-02
## Trp_T5 -4.088646e-02 4.200130e-02 -1.838998e-03 -7.550473e-02
## Phe_T5 6.025645e-03 3.737137e-02 -1.040535e-02 -3.756055e-03
## Met_T5 -1.010016e-02 -4.155338e-02 -1.091402e-01 -5.682001e-02
## Orn_T5 6.846315e-02 -9.632045e-03 3.524526e-02 5.963437e-02
## Arg_T5 -1.685596e-02 -2.745376e-02 6.223140e-03 -3.302044e-02
## His_T5 -3.166296e-03 2.949072e-03 -2.212594e-02 3.119572e-02
## Asn_T5 -4.238956e-02 -3.878704e-03 -2.396376e-02 2.703009e-02
## Asp_T5 -2.046504e-02 -8.070707e-03 2.836920e-02 9.547651e-02
## Glu_T5 1.766212e-02 1.674443e-02 1.817142e-03 4.998342e-02
## Gln_T5 1.455899e-02 1.650833e-02 -3.541299e-02 1.769918e-02
## Cit_T5 -5.940502e-03 4.062371e-02 4.448761e-02 -4.014506e-03
## Tyr_T5 2.175484e-02 1.939684e-02 -3.407922e-02 -3.175147e-02
## Thr_T5 4.643260e-03 -5.158544e-02 6.776607e-02 4.366882e-04
## Lys_T5 1.344589e-02 2.119614e-02 1.850358e-02 -5.820072e-02
## Creatinine_T5 -3.891051e-02 3.192972e-02 -1.233823e-01 -8.780096e-02
## Kynurenine_T5 -6.790225e-02 -2.273415e-02 -1.169923e-02 5.399553e-02
## Putrescine_T5 -4.551039e-02 5.344340e-02 1.041270e-01 -7.064234e-02
## Sarcosine_T5 4.462548e-02 -1.060610e-02 -1.020983e-01 -3.308961e-02
## Serotonin_T5 -2.407684e-02 1.233327e-03 -4.454810e-02 -4.299751e-02
## Taurine_T5 4.275405e-02 -3.400156e-03 -7.477988e-02 8.211890e-02
## SDMA_T5 -7.191241e-03 -9.145204e-03 -6.583529e-03 -5.363682e-03
## C0_T5 -1.159347e-02 5.105701e-02 -2.183733e-02 -9.502992e-03
## C2_T5 -1.258282e-01 4.435295e-02 -4.937393e-02 -3.015263e-02
## C3.OH_T5 1.634429e-03 -3.684104e-03 5.082671e-03 -2.099118e-04
## C6..C4.1.DC._T5 6.500731e-02 8.132438e-02 1.563093e-01 -2.820093e-03
## C5.DC..C6.OH._T5 -1.172526e-02 -1.344788e-03 -1.938603e-02 -2.199761e-02
## C7.DC_T5 -5.039519e-02 -2.142538e-02 2.385362e-02 1.837777e-02
## C8_T5 3.132315e-03 -5.029991e-03 5.172846e-03 4.177123e-03
## C10_T5 1.656454e-03 -9.316374e-03 1.696124e-03 6.397771e-03
## C10.1_T5 -1.191559e-02 -8.165869e-02 -5.870505e-03 -1.891337e-02
## C10.2_T5 1.456168e-03 -5.573318e-03 3.746525e-03 -1.976838e-04
## C14.1_T5 -5.271323e-04 -5.020701e-03 2.890582e-03 -1.719320e-03
## C14.2_T5 6.445596e-04 -4.696579e-03 3.384486e-03 3.984659e-04
## C16.1_T5 5.362316e-04 -4.869440e-03 2.686849e-03 -1.596213e-03
## C16.2_T5 7.029253e-04 -4.988720e-03 3.144477e-03 -1.446168e-03
## C16.2.OH_T5 -8.024819e-03 8.086120e-03 1.355295e-02 4.486308e-02
## C18.1_T5 -3.308839e-04 -4.719361e-03 2.350611e-03 -1.412397e-03
## C18.1.OH_T5 5.119609e-04 -4.819003e-03 2.742021e-03 -1.080217e-03
## C18.2_T5 7.865301e-04 -4.873051e-03 3.557322e-03 -1.485867e-03
## lysoPC.a.C16.0_T5 1.160088e-02 2.176183e-02 1.416990e-02 2.761551e-02
## lysoPC.a.C16.1_T5 4.451875e-02 3.462015e-02 -1.487590e-02 -1.586742e-03
## lysoPC.a.C17.0_T5 2.782078e-03 -1.326639e-02 -1.094991e-02 4.346435e-03
## lysoPC.a.C18.0_T5 1.513190e-03 5.824165e-03 9.514178e-03 3.204567e-03
## lysoPC.a.C18.1_T5 -5.132473e-02 1.259240e-02 -4.092793e-02 1.054859e-02
## lysoPC.a.C18.2_T5 -2.664285e-02 2.070686e-03 -2.585070e-02 6.645601e-02
## lysoPC.a.C20.3_T5 3.824849e-02 4.786458e-03 -1.649133e-02 7.274634e-02
## lysoPC.a.C20.4_T5 -3.595378e-03 1.117060e-02 7.037118e-03 9.208036e-02
## lysoPC.a.C24.0_T5 3.938657e-03 -6.294465e-03 7.307146e-03 -3.814087e-03
## lysoPC.a.C26.0_T5 3.594179e-03 3.299938e-04 8.496731e-03 -2.002815e-03
## lysoPC.a.C26.1_T5 9.351273e-04 -3.927562e-03 5.072345e-03 -7.146002e-04
## lysoPC.a.C28.0_T5 5.921783e-04 -7.830675e-03 4.774435e-02 -1.264752e-01
## lysoPC.a.C28.1_T5 4.217834e-03 -5.825626e-03 4.211584e-03 -3.192744e-04
## PC.aa.C24.0_T5 8.044480e-02 -7.304873e-02 -7.086872e-03 -8.972769e-02
## PC.aa.C28.1_T5 4.825156e-03 2.909717e-03 6.858507e-03 2.856782e-03
## PC.aa.C30.0_T5 6.198450e-03 1.074677e-02 9.016730e-04 6.518261e-03
## PC.aa.C32.0_T5 2.319007e-02 3.914376e-02 -3.010074e-02 1.190019e-02
## PC.aa.C32.1_T5 9.325103e-02 4.770373e-02 -2.072622e-02 -4.017156e-03
## PC.aa.C32.3_T5 1.844037e-03 -5.145061e-03 1.936312e-03 -3.940912e-04
## PC.aa.C34.1_T5 1.213417e-02 1.740112e-02 -2.911015e-02 2.895786e-02
## PC.aa.C34.2_T5 3.812046e-02 -9.466442e-03 2.130815e-02 2.428663e-02
## PC.aa.C34.3_T5 9.697656e-02 1.630324e-02 -1.098011e-02 5.651430e-03
## PC.aa.C34.4_T5 7.181871e-03 -4.397249e-03 -2.377730e-03 4.434318e-03
## PC.aa.C36.0_T5 3.277461e-03 2.475818e-03 -2.541152e-03 -1.422899e-02
## PC.aa.C36.1_T5 1.610321e-02 -2.762112e-02 -5.657103e-02 -5.027229e-03
## PC.aa.C36.2_T5 2.628302e-02 -1.823707e-02 -3.907663e-03 -2.874910e-02
## PC.aa.C36.3_T5 7.216462e-02 1.278404e-02 -5.004173e-02 4.674763e-02
## PC.aa.C36.4_T5 4.300588e-02 -1.752188e-02 -4.579285e-03 6.044402e-02
## PC.aa.C36.5_T5 -1.680914e-02 -1.703603e-02 -1.088333e-01 -4.573507e-02
## PC.aa.C38.0_T5 -3.421383e-02 1.364583e-02 -4.958969e-02 -4.048201e-02
## PC.aa.C38.1_T5 7.032599e-03 6.158823e-03 -3.211169e-03 -1.217964e-02
## PC.aa.C38.3_T5 8.401673e-02 1.544881e-02 -3.539716e-02 4.331257e-02
## PC.aa.C38.4_T5 3.721230e-02 -6.268238e-03 1.069868e-03 3.186767e-02
## PC.aa.C38.5_T5 1.800039e-02 2.457727e-02 -6.642515e-03 -6.969446e-03
## PC.aa.C38.6_T5 -1.273720e-02 1.249064e-02 -5.998865e-02 -3.369463e-02
## PC.aa.C40.1_T5 2.276167e-02 -3.019358e-02 7.158363e-02 -1.353406e-01
## PC.aa.C40.2_T5 7.665041e-03 -2.446329e-04 8.486395e-03 -3.512689e-03
## PC.aa.C40.3_T5 8.252138e-03 2.507984e-03 8.269519e-03 -4.721433e-03
## PC.aa.C40.4_T5 1.317235e-02 1.522707e-02 2.515293e-02 -6.880343e-03
## PC.aa.C40.5_T5 3.892879e-03 2.789110e-02 3.151201e-03 -1.435688e-02
## PC.aa.C40.6_T5 -5.780979e-03 1.351213e-02 -7.592793e-02 -4.681194e-02
## PC.aa.C42.0_T5 -7.478434e-04 -1.450289e-03 -5.688836e-03 -5.589623e-03
## PC.aa.C42.1_T5 1.291793e-03 -1.684390e-03 -8.768155e-04 -3.817198e-03
## PC.aa.C42.2_T5 3.599035e-03 -2.922146e-03 4.831054e-03 -5.608948e-03
## PC.aa.C42.4_T5 4.495157e-03 -1.548334e-03 7.636920e-03 -1.861050e-03
## PC.aa.C42.5_T5 3.494712e-03 -2.408399e-03 1.351638e-03 -6.779735e-04
## PC.aa.C42.6_T5 -7.282870e-02 1.195390e-02 1.238757e-02 -8.004739e-03
## PC.ae.C30.0_T5 -2.880665e-02 -4.372447e-03 1.642803e-02 3.442328e-02
## PC.ae.C32.1_T5 -6.510425e-03 1.398804e-02 1.111944e-02 7.510269e-03
## PC.ae.C32.2_T5 -6.163385e-04 -1.773943e-03 -1.769977e-04 -4.706319e-03
## PC.ae.C34.0_T5 3.869252e-03 -3.471890e-03 -5.329338e-04 3.121347e-03
## PC.ae.C34.1_T5 3.164128e-03 -4.444090e-04 -3.189058e-02 1.112537e-02
## PC.ae.C34.2_T5 -2.524268e-02 5.158723e-03 -3.357219e-02 -1.510845e-02
## PC.ae.C34.3_T5 -2.239865e-02 -4.712179e-02 -2.724658e-02 2.121625e-03
## PC.ae.C36.0_T5 -7.772987e-03 4.144639e-03 3.860922e-03 -1.252618e-02
## PC.ae.C36.1_T5 3.003064e-02 4.621453e-03 -2.887071e-04 4.996455e-03
## PC.ae.C36.2_T5 4.008748e-02 -3.210691e-02 -2.855706e-02 5.260212e-04
## PC.ae.C36.3_T5 -9.709423e-03 -3.701000e-03 -2.624241e-02 -1.332089e-03
## PC.ae.C36.4_T5 -4.900403e-02 6.544854e-02 -2.341743e-02 2.575548e-04
## PC.ae.C36.5_T5 -2.528522e-02 2.316657e-02 -3.515697e-02 5.353526e-02
## PC.ae.C38.0_T5 4.332567e-03 -1.039907e-05 -1.129732e-02 -7.013691e-03
## PC.ae.C38.2_T5 2.942671e-02 1.430953e-03 2.052230e-02 -4.962246e-03
## PC.ae.C38.3_T5 1.962232e-02 -8.564865e-03 -5.485240e-03 1.830710e-02
## PC.ae.C38.4_T5 1.900477e-02 -1.085416e-02 8.696199e-03 3.301920e-02
## PC.ae.C38.5_T5 -6.828767e-02 3.968783e-02 -3.469725e-02 -2.312278e-02
## PC.ae.C38.6_T5 -2.411862e-02 1.424122e-02 -3.278106e-02 -1.274579e-02
## PC.ae.C40.1_T5 7.046339e-03 -2.186589e-03 1.697068e-03 -7.028483e-03
## PC.ae.C40.2_T5 4.095610e-03 -3.079531e-03 -9.385036e-03 -2.288928e-03
## PC.ae.C40.3_T5 1.069446e-02 -2.352761e-03 2.632826e-03 1.313637e-02
## PC.ae.C40.4_T5 5.292970e-03 1.077952e-02 1.488682e-02 8.411714e-03
## PC.ae.C40.5_T5 -8.041828e-03 -1.237549e-03 -2.460355e-04 -2.689182e-03
## PC.ae.C40.6_T5 -1.975660e-02 -4.955494e-03 -3.067441e-02 -1.629586e-02
## PC.ae.C42.1_T5 6.008552e-03 -1.088671e-03 6.570596e-03 -1.725064e-03
## PC.ae.C42.2_T5 4.510001e-03 -1.981541e-03 -2.385275e-03 -2.327841e-03
## PC.ae.C42.3_T5 5.054569e-03 -1.130538e-03 3.508568e-03 -2.563966e-03
## PC.ae.C42.4_T5 5.806277e-03 1.573357e-03 7.260929e-03 4.203770e-03
## PC.ae.C42.5_T5 -1.194159e-02 3.850140e-03 -7.061384e-03 -3.575827e-03
## PC.ae.C44.3_T5 4.181571e-03 -1.954463e-03 5.327805e-03 -1.283833e-03
## PC.ae.C44.4_T5 2.477891e-03 -3.787542e-03 -1.133262e-03 -1.549697e-03
## PC.ae.C44.5_T5 -7.693542e-03 -7.967067e-03 -1.254030e-02 -8.805506e-03
## PC.ae.C44.6_T5 2.767841e-03 -6.806991e-03 -4.169909e-03 -2.431146e-03
## SM..OH..C14.1_T5 7.409197e-03 -2.167392e-02 -1.593811e-02 1.564585e-03
## SM..OH..C16.1_T5 4.775700e-03 -1.234330e-02 -1.653738e-02 7.279738e-03
## SM..OH..C22.1_T5 2.044719e-03 -1.223480e-02 4.998330e-02 -1.828390e-02
## SM..OH..C22.2_T5 -3.466251e-03 -2.757880e-02 9.079549e-03 -1.411447e-02
## SM..OH..C24.1_T5 -3.110955e-04 -3.752284e-03 5.125309e-03 1.154184e-03
## SM.C16.0_T5 -1.099966e-02 3.729468e-02 -1.625917e-02 3.231771e-02
## SM.C16.1_T5 -4.901089e-02 -7.370282e-03 1.928279e-02 -2.890613e-02
## SM.C18.0_T5 5.290456e-02 2.562524e-02 -1.136471e-02 4.160703e-02
## SM.C18.1_T5 -1.367238e-02 -1.103786e-02 4.313382e-03 5.655698e-03
## SM.C20.2_T5 3.329037e-03 -3.948888e-03 2.329421e-03 1.914815e-03
## SM.C24.0_T5 1.201470e-02 -1.136474e-02 2.153050e-02 2.072764e-02
## SM.C24.1_T5 -1.060684e-03 1.788389e-02 -4.742625e-02 4.260675e-02
## PC29 PC30 PC31 PC32
## GLU_T0 -1.790906e-02 7.906290e-03 2.109214e-02 0.0699200309
## INS_T0 -4.452453e-02 5.343923e-02 -1.162893e-02 0.0327575490
## HOMA_T0 -3.711695e-02 4.152912e-02 -6.838792e-03 0.0402124108
## HBA1C_T0 -3.686088e-05 2.207351e-02 2.596719e-02 -0.0254609230
## HBA1C.mmol.mol_T0 1.121399e-02 4.115266e-02 6.145962e-02 -0.0749300698
## PESO_T0 7.025288e-02 -2.980327e-02 -1.907826e-03 -0.0491126100
## bmi_T0 7.101574e-02 -1.592726e-02 3.560747e-02 -0.0190772940
## CC_T0 7.825635e-03 5.455575e-03 7.759674e-03 0.0113747148
## CINT_T0 1.035211e-01 -2.861599e-02 3.125923e-02 -0.0366086110
## CAD_T0 4.542051e-02 -9.497781e-03 3.444639e-02 -0.1142895370
## TAD_T0 1.097964e-02 7.495197e-02 4.481029e-02 -0.0194661854
## TAS_T0 -3.385137e-02 5.090153e-02 1.020968e-02 -0.0163415276
## TG_T0 7.695801e-02 1.079485e-01 -8.787045e-02 0.0412776010
## COL_T0 1.727134e-02 -1.245109e-02 8.711958e-02 -0.0294328560
## LDL_T0 4.330979e-02 -6.025097e-03 1.109099e-01 0.0038175411
## HDL_T0 -3.489376e-02 -7.339026e-02 -2.764138e-03 -0.0507637083
## VLDL_T0 7.738630e-02 1.093717e-01 -8.795318e-02 0.0427887462
## PCR_T0 2.465495e-02 -5.434997e-03 2.345402e-02 0.0352239532
## LEP_T0 3.401750e-02 3.923885e-03 3.643302e-02 -0.0089590480
## ADIPO_T0 -4.700989e-02 1.034369e-02 -7.607591e-02 0.0022763320
## GOT_T0 7.455592e-02 5.429032e-02 -1.849528e-02 -0.0401898259
## GPT_T0 1.288475e-02 2.340881e-02 -3.063516e-02 -0.0233647889
## GGT_T0 1.144469e-01 -1.855699e-02 -1.159828e-02 0.0226001393
## URICO_T0 1.246616e-02 -2.532154e-02 -1.902146e-02 0.0087589019
## CREAT_T0 -3.276429e-04 -7.198971e-03 3.068938e-03 -0.0014782731
## UREA_T0 -3.220845e-02 -1.277350e-01 3.090722e-02 -0.0629677153
## HIERRO_T0 -3.164237e-02 -9.376169e-03 -3.051336e-03 -0.0119760330
## TRANSF_T0 -6.526605e-02 -5.239492e-02 2.995152e-02 0.0666832747
## FERR_T0 9.022415e-03 1.986946e-02 -7.827128e-02 0.0074574583
## Ile_T0 -1.221253e-01 8.621804e-03 5.709224e-02 -0.0310941971
## Leu_T0 -1.296989e-01 -2.161588e-02 7.516511e-02 -0.0254102006
## Val_T0 -5.597950e-02 -6.390066e-02 4.686816e-02 -0.0107106418
## Ala_T0 3.990499e-02 5.436716e-02 -6.768553e-02 0.0346154773
## Pro_T0 -6.895418e-02 -7.286989e-04 -7.074011e-03 0.0601249213
## Gly_T0 -8.277426e-02 -2.357164e-03 -9.258060e-02 -0.0349085739
## Ser_T0 -7.695129e-02 -3.316737e-02 -3.400400e-02 -0.0256928003
## Trp_T0 -6.188935e-03 -7.256690e-03 -1.885192e-02 -0.0659532583
## Phe_T0 -2.958239e-02 1.146229e-02 -1.391154e-02 -0.0340204535
## Met_T0 -9.488313e-04 2.322654e-02 -2.537521e-02 0.0029768618
## Orn_T0 5.274738e-02 1.100935e-03 2.232221e-02 0.0471204569
## Arg_T0 4.891934e-03 -7.876705e-02 3.817732e-02 0.0600741318
## His_T0 -3.789476e-02 -4.348713e-02 3.565227e-02 -0.0179398493
## Asn_T0 -3.564949e-02 3.829716e-02 1.449611e-01 -0.0437593414
## Asp_T0 4.404533e-02 -7.443458e-02 1.390183e-03 0.0288527103
## Glu_T0 4.648941e-02 -2.539456e-02 1.770417e-02 0.0348224299
## Gln_T0 -3.654019e-02 2.094983e-02 -9.085165e-03 0.0535298305
## Cit_T0 8.699491e-02 3.007418e-02 -9.524344e-03 0.0389879036
## Tyr_T0 -1.908489e-02 -1.713954e-02 -5.403030e-02 -0.1057489714
## Thr_T0 -4.216801e-02 -1.112345e-01 1.868544e-02 0.0802896736
## Lys_T0 -4.829986e-02 -3.523697e-02 1.909878e-02 -0.0561113601
## Creatinine_T0 4.145564e-02 -4.036205e-02 -8.986026e-02 0.0391727113
## Kynurenine_T0 -3.001029e-02 -7.495730e-03 1.563664e-02 -0.0049806896
## Putrescine_T0 -1.125457e-01 -5.294667e-02 -1.150327e-01 0.1299070497
## Sarcosine_T0 2.577060e-02 -7.858692e-03 3.930989e-03 -0.0291981994
## Serotonin_T0 -7.011672e-02 -3.742605e-03 -1.560111e-01 -0.0535186815
## Taurine_T0 -3.442256e-02 -9.651421e-02 -2.288664e-02 0.0151027371
## SDMA_T0 -1.399584e-02 -9.195732e-03 3.911046e-03 0.0024730178
## C0_T0 1.654919e-02 5.223791e-02 -3.086012e-02 0.0151413487
## C2_T0 -1.431441e-01 -2.606211e-02 -1.353798e-01 0.0283405831
## C3.OH_T0 -6.812222e-04 4.610043e-03 6.250858e-04 0.0058813809
## C6..C4.1.DC._T0 -6.419746e-02 -5.366519e-03 -1.320337e-02 -0.1685608018
## C5.DC..C6.OH._T0 1.611611e-02 -7.544905e-02 -1.006158e-01 -0.0291494694
## C7.DC_T0 6.002286e-02 -6.292028e-02 -1.029778e-01 -0.0002397127
## C8_T0 2.888853e-03 -1.244414e-03 6.518157e-03 0.0052447631
## C10_T0 -1.186022e-03 7.304987e-03 8.860856e-04 0.0061996843
## C10.1_T0 -3.636043e-04 5.037831e-03 1.965485e-03 0.0074673781
## C10.2_T0 -1.052217e-03 4.058030e-03 5.352966e-03 0.0046641190
## C14.1_T0 -3.572563e-03 5.335782e-03 6.369721e-04 0.0057146188
## C14.2_T0 -1.742656e-03 4.816527e-03 3.146648e-03 0.0045916306
## C16.1_T0 -1.613067e-03 4.059117e-03 1.705855e-03 0.0052273025
## C16.2_T0 -1.350209e-03 2.839213e-03 3.101445e-03 0.0066911939
## C16.2.OH_T0 -1.113140e-03 4.432617e-03 3.547203e-03 0.0069559057
## C18.1_T0 -8.887285e-04 4.405269e-03 -4.011857e-04 0.0058992562
## C18.1.OH_T0 -6.923796e-04 3.982070e-03 2.795359e-03 0.0065296722
## C18.2_T0 -1.696049e-03 3.243124e-03 1.549722e-03 0.0058095430
## lysoPC.a.C16.0_T0 2.278103e-02 3.470751e-02 1.907807e-02 0.0565756587
## lysoPC.a.C16.1_T0 5.215331e-03 1.723693e-02 -2.928816e-03 0.0201107987
## lysoPC.a.C17.0_T0 1.466659e-02 1.351754e-02 -1.274371e-02 0.0004415377
## lysoPC.a.C18.0_T0 6.222894e-03 5.908994e-02 3.042882e-02 0.0325518044
## lysoPC.a.C18.1_T0 3.717808e-02 6.179052e-02 1.686039e-02 0.0224330796
## lysoPC.a.C18.2_T0 -3.313775e-02 1.691171e-02 3.275115e-03 -0.0568513376
## lysoPC.a.C20.3_T0 2.542746e-02 4.158134e-02 2.307099e-02 0.0209903640
## lysoPC.a.C20.4_T0 1.982372e-02 5.222527e-02 1.586266e-02 0.0125064474
## lysoPC.a.C24.0_T0 -1.261630e-03 6.594459e-03 8.492883e-03 0.0062241585
## lysoPC.a.C26.0_T0 -9.971934e-02 -2.590560e-02 1.028428e-02 0.1079828686
## lysoPC.a.C26.1_T0 -5.221029e-03 1.109469e-03 4.170257e-03 0.0042889323
## lysoPC.a.C28.0_T0 -9.957710e-02 -9.974875e-02 8.047244e-02 0.1100546944
## lysoPC.a.C28.1_T0 -2.158756e-04 2.867363e-03 3.952010e-03 0.0050789126
## PC.aa.C24.0_T0 -6.464941e-02 2.890112e-02 3.873059e-02 0.0953659065
## PC.aa.C28.1_T0 -1.818031e-03 2.466749e-02 9.570470e-03 -0.0166098239
## PC.aa.C30.0_T0 1.346791e-02 -1.762702e-02 3.542120e-02 -0.0004891281
## PC.aa.C32.0_T0 -2.845990e-02 -3.344366e-02 4.020143e-02 0.0100132286
## PC.aa.C32.1_T0 -2.721617e-03 -5.717273e-02 1.302132e-02 0.0274397083
## PC.aa.C32.3_T0 -1.326742e-03 1.358822e-03 -1.202298e-03 0.0057162638
## PC.aa.C34.1_T0 8.268198e-02 -1.503835e-02 -2.321759e-02 0.0185427051
## PC.aa.C34.2_T0 3.824176e-03 -6.324836e-02 -2.093637e-02 -0.0419569559
## PC.aa.C34.3_T0 7.146951e-03 -3.989076e-02 -4.832858e-02 -0.0048329895
## PC.aa.C34.4_T0 1.155246e-02 3.241958e-04 8.249238e-03 0.0098205652
## PC.aa.C36.0_T0 -1.022778e-04 -2.792512e-02 1.117922e-02 -0.0045563000
## PC.aa.C36.1_T0 5.637854e-02 8.942451e-03 2.563754e-02 0.0075930254
## PC.aa.C36.2_T0 2.188382e-02 -1.981692e-04 -5.062547e-02 -0.0430179492
## PC.aa.C36.3_T0 3.775965e-02 1.990245e-02 -2.328135e-02 0.0179392364
## PC.aa.C36.4_T0 1.352496e-02 3.735576e-02 -5.288880e-02 0.0007457426
## PC.aa.C36.5_T0 3.690502e-02 -6.380547e-02 -6.652613e-02 -0.0423527726
## PC.aa.C38.0_T0 1.822822e-03 -3.480853e-02 1.311450e-02 -0.0102994483
## PC.aa.C38.1_T0 1.016866e-02 -4.999918e-02 -1.873934e-02 -0.0031285638
## PC.aa.C38.3_T0 4.942999e-02 2.272257e-02 -1.322075e-02 0.0567563443
## PC.aa.C38.4_T0 2.040964e-02 6.478635e-02 -4.044923e-02 0.0037376541
## PC.aa.C38.5_T0 2.376327e-02 4.874092e-02 -3.065225e-02 0.0001071658
## PC.aa.C38.6_T0 3.762915e-02 1.755173e-02 1.979482e-03 0.0252780025
## PC.aa.C40.1_T0 -1.429707e-02 4.481177e-02 1.101069e-01 -0.0937719027
## PC.aa.C40.2_T0 1.599586e-03 -4.077868e-03 8.102805e-03 -0.0056586583
## PC.aa.C40.3_T0 1.037417e-03 -4.530252e-03 8.296582e-03 -0.0051231970
## PC.aa.C40.4_T0 -1.234193e-02 4.071040e-03 3.317557e-02 0.0016014422
## PC.aa.C40.5_T0 -1.404386e-02 1.236360e-02 4.339190e-02 -0.0118559984
## PC.aa.C40.6_T0 1.963705e-02 -9.249186e-03 5.693849e-02 0.0042173881
## PC.aa.C42.0_T0 8.984994e-04 -1.034848e-02 6.600593e-03 -0.0076405936
## PC.aa.C42.1_T0 1.250003e-03 -2.591078e-03 3.312594e-03 0.0008810293
## PC.aa.C42.2_T0 -1.105136e-03 -2.902180e-03 5.553019e-03 -0.0004162862
## PC.aa.C42.4_T0 -2.523066e-03 5.130427e-04 5.221071e-03 0.0016085183
## PC.aa.C42.5_T0 -1.435327e-03 1.896476e-03 7.082665e-03 0.0011515799
## PC.aa.C42.6_T0 -6.208633e-02 6.935339e-03 -2.501179e-02 0.0851544280
## PC.ae.C30.0_T0 -5.512167e-04 1.770539e-03 6.392285e-03 0.0033765323
## PC.ae.C32.1_T0 -1.808206e-02 -2.399661e-02 -8.754739e-03 -0.0118085882
## PC.ae.C32.2_T0 -5.741194e-03 -2.047457e-03 -3.641724e-03 0.0015824449
## PC.ae.C34.0_T0 -6.614384e-03 -6.869939e-03 8.029580e-03 -0.0003631068
## PC.ae.C34.1_T0 2.221788e-02 -3.660257e-02 -1.928058e-02 -0.0225323733
## PC.ae.C34.2_T0 3.844037e-03 -6.342241e-02 -5.083556e-02 -0.0576134113
## PC.ae.C34.3_T0 -2.562429e-02 -1.741075e-02 -1.130061e-02 -0.0639319620
## PC.ae.C36.0_T0 2.353337e-03 -3.107331e-03 1.148635e-02 0.0005434930
## PC.ae.C36.1_T0 1.488635e-02 -1.557179e-02 -3.849856e-03 -0.0180860090
## PC.ae.C36.2_T0 2.015028e-02 -5.986327e-02 -4.856170e-02 -0.0598486074
## PC.ae.C36.3_T0 4.066390e-03 -2.114421e-02 -3.575580e-02 -0.0258423539
## PC.ae.C36.4_T0 -2.006872e-02 -3.696623e-02 -2.558443e-03 -0.0165274609
## PC.ae.C36.5_T0 -5.371087e-02 -4.403529e-02 1.752392e-02 0.0062780592
## PC.ae.C38.0_T0 1.222305e-02 -3.775995e-03 -2.804655e-03 0.0051052381
## PC.ae.C38.2_T0 -3.072747e-03 -1.249479e-02 5.878003e-03 -0.0192193673
## PC.ae.C38.3_T0 2.730203e-02 -8.889442e-03 -5.855107e-03 -0.0041369090
## PC.ae.C38.4_T0 2.971129e-03 -4.799703e-03 -5.693192e-02 -0.0246223841
## PC.ae.C38.5_T0 -2.358203e-02 1.194882e-02 -2.854795e-02 -0.0161675684
## PC.ae.C38.6_T0 -1.010720e-02 -1.941612e-02 -3.221375e-03 0.0136858404
## PC.ae.C40.1_T0 2.719211e-03 -1.724733e-02 1.796234e-02 -0.0028604139
## PC.ae.C40.2_T0 5.546202e-03 -4.186633e-03 -2.766600e-03 -0.0118616515
## PC.ae.C40.3_T0 1.132596e-02 -9.502117e-03 -2.214264e-03 -0.0063642361
## PC.ae.C40.4_T0 7.051962e-03 -1.712420e-02 1.028350e-03 -0.0218775183
## PC.ae.C40.5_T0 1.090023e-03 -8.850024e-03 -3.777063e-03 -0.0132708760
## PC.ae.C40.6_T0 3.451749e-03 -9.588795e-03 -7.879364e-03 -0.0106839541
## PC.ae.C42.1_T0 9.621177e-04 -2.254911e-03 9.016444e-03 0.0015389183
## PC.ae.C42.2_T0 -2.931984e-04 -2.886981e-03 6.091558e-03 -0.0059233274
## PC.ae.C42.3_T0 5.585012e-03 -1.320907e-02 4.804788e-03 -0.0084697631
## PC.ae.C42.4_T0 3.563536e-04 -1.136190e-02 1.564971e-03 -0.0155894620
## PC.ae.C42.5_T0 1.329867e-02 -2.274850e-02 -1.101669e-02 -0.0285630320
## PC.ae.C44.3_T0 -8.778543e-04 -7.408456e-04 4.556560e-03 0.0009401359
## PC.ae.C44.4_T0 3.995532e-03 -6.548327e-03 1.960472e-03 0.0002676674
## PC.ae.C44.5_T0 1.998637e-02 -4.218418e-02 -1.761055e-02 -0.0384873370
## PC.ae.C44.6_T0 5.805583e-03 -2.563532e-02 2.212979e-03 -0.0246109932
## SM..OH..C14.1_T0 -4.195609e-03 1.846113e-02 -4.732172e-02 0.0048966577
## SM..OH..C16.1_T0 6.674251e-03 1.194834e-02 -2.204807e-02 0.0024676850
## SM..OH..C22.1_T0 4.085128e-02 -5.979411e-03 -8.295999e-02 0.0086728371
## SM..OH..C22.2_T0 2.384887e-02 1.488855e-02 -8.334611e-02 0.0129637300
## SM..OH..C24.1_T0 5.236532e-03 5.497596e-03 -4.210537e-03 0.0058197175
## SM.C16.0_T0 -2.045637e-02 2.536576e-02 4.600780e-05 0.0025033478
## SM.C16.1_T0 -2.019508e-02 4.337024e-02 -8.567100e-02 0.0029739792
## SM.C18.0_T0 -1.366248e-03 3.866667e-03 -8.748730e-02 -0.0299372878
## SM.C18.1_T0 9.370472e-03 1.187689e-02 -1.421612e-01 0.0186642033
## SM.C20.2_T0 8.933152e-04 2.857140e-03 4.396774e-04 0.0077166783
## SM.C24.0_T0 3.117807e-02 1.804560e-02 -1.401395e-03 0.0020127468
## SM.C24.1_T0 5.457287e-02 2.286903e-03 -3.772816e-02 -0.0125704548
## MEDDM_T2 -9.497074e-04 3.383742e-03 3.413898e-03 0.0068377480
## MEDCOL_T2 -9.497074e-04 3.383742e-03 3.413898e-03 0.0068377480
## MEDINF_T2 5.985861e-03 9.355440e-04 1.464672e-02 0.0036884320
## MEDHTA_T2 1.277765e-03 -1.503679e-02 8.271847e-03 0.0027388128
## GLU_T2 -2.073921e-02 -7.180508e-03 3.304928e-02 0.0005226389
## INS_T2 8.462513e-02 -2.205072e-02 -1.710465e-03 0.0440111141
## HOMA_T2 4.942707e-02 -2.877420e-03 1.026834e-02 0.0403512113
## HBA1C_T2 -7.737721e-03 8.366559e-03 4.671216e-03 -0.0169795052
## HBA1C.mmol.mol_T2 -1.564479e-02 2.861639e-03 4.261627e-05 -0.0669343859
## PESO_T2 4.216915e-02 -1.815537e-02 -4.663942e-02 -0.0350836507
## bmi_T2 3.901522e-02 -9.867025e-03 1.922719e-03 -0.0047823405
## CC_T2 3.047670e-03 2.089774e-03 4.416354e-03 0.0065567280
## CINT_T2 7.540875e-02 -1.496831e-02 -3.787001e-02 -0.0087269955
## CAD_T2 1.672855e-02 2.142761e-02 -3.182390e-02 -0.0174488755
## TAD_T2 2.723325e-02 -2.757661e-02 1.031454e-03 0.0095987763
## TAS_T2 3.251339e-02 8.279241e-02 -3.994126e-02 0.0335271966
## TG_T2 -5.707769e-02 -4.866613e-02 -5.017962e-02 0.0274140711
## COL_T2 -5.430221e-02 -6.057967e-02 2.485863e-02 0.0002265004
## LDL_T2 -5.051644e-02 -4.899702e-02 5.809641e-02 0.0109682392
## HDL_T2 3.212886e-03 -6.186067e-02 -3.898585e-02 0.0464712754
## VLDL_T2 -7.685339e-03 -1.819517e-02 -1.139976e-02 0.1142620980
## PCR_T2 -9.967722e-03 7.132866e-02 1.118727e-01 0.0338669754
## LEP_T2 -8.733534e-03 1.803437e-02 7.877823e-02 0.0080273201
## ADIPO_T2 -4.398614e-02 1.538199e-02 -6.586366e-03 0.0336526987
## GOT_T2 4.888928e-02 -7.108459e-04 -7.385087e-02 0.0053225352
## GPT_T2 2.241124e-02 -1.074990e-01 -9.630821e-02 -0.0595542772
## GGT_T2 -8.311785e-02 -6.240225e-02 -2.212471e-02 0.0377337374
## URICO_T2 9.150903e-02 -3.284151e-02 -5.202346e-02 0.0510883437
## CREAT_T2 1.066616e-03 -7.678323e-04 3.573025e-03 -0.0010781735
## UREA_T2 9.051390e-02 -5.279393e-02 2.382425e-03 -0.0061993180
## HIERRO_T2 -1.143768e-01 -1.660937e-02 1.972413e-02 0.0083488953
## TRANSF_T2 -4.716083e-02 -1.090264e-01 1.367580e-02 0.0428983516
## FERR_T2 9.510143e-02 -3.940589e-03 -3.832529e-03 -0.0446729441
## Ile_T2 -3.432251e-03 3.190502e-02 -2.648356e-02 0.0302927397
## Leu_T2 1.994781e-02 3.840470e-04 -1.515197e-02 0.0779481106
## Val_T2 4.633080e-02 -2.075093e-02 -8.263372e-03 0.0364420420
## Ala_T2 -4.516590e-02 -2.129542e-02 4.458338e-03 0.0181030634
## Pro_T2 -8.426322e-03 1.462293e-02 -7.022733e-02 -0.0774286231
## Gly_T2 -9.081203e-02 -2.575842e-02 3.705112e-04 -0.0661071738
## Ser_T2 -2.445377e-02 7.810635e-03 -3.148286e-02 -0.0646681130
## Trp_T2 3.255063e-02 -2.255854e-02 5.524468e-02 -0.0005555078
## Phe_T2 1.816335e-02 4.373714e-02 -1.176163e-02 0.0104061992
## Met_T2 -6.401129e-03 -4.302871e-02 2.220155e-03 0.0342064155
## Orn_T2 1.112678e-01 -1.307602e-02 -3.381062e-03 0.0254676889
## Arg_T2 2.748280e-02 -7.882931e-03 5.826219e-02 -0.0015068535
## His_T2 4.428325e-02 -7.150117e-02 -6.020504e-03 0.0444248413
## Asn_T2 8.190224e-03 5.287786e-03 3.651508e-02 -0.0188816045
## Asp_T2 4.515307e-02 -8.438275e-02 -3.695025e-02 0.0247181677
## Glu_T2 4.730526e-02 -5.361973e-02 -9.813538e-03 0.0044471591
## Gln_T2 5.680365e-02 -6.222405e-02 -2.521032e-02 0.0199807989
## Cit_T2 1.033802e-01 -1.897749e-02 8.246520e-04 -0.0930729717
## Tyr_T2 -2.389599e-02 6.744119e-03 -3.442682e-02 0.0666316706
## Thr_T2 5.188428e-02 -5.405602e-02 -6.299646e-02 0.0534324874
## Lys_T2 -3.102876e-02 2.182606e-02 -2.077196e-03 0.0930420241
## Creatinine_T2 3.730509e-02 -7.413865e-02 2.260438e-02 -0.0539056101
## Kynurenine_T2 7.304717e-03 1.964796e-02 2.883168e-02 -0.0429064216
## Putrescine_T2 -1.151153e-01 1.110171e-01 8.747377e-02 -0.0038149203
## Sarcosine_T2 -1.727606e-02 -6.030211e-02 -4.673680e-02 0.0298182280
## Serotonin_T2 1.536161e-02 1.002270e-01 5.471002e-02 0.0895954338
## Taurine_T2 -1.540692e-01 2.733487e-01 -1.027343e-01 -0.0483065382
## SDMA_T2 -4.069087e-03 2.245293e-02 2.665943e-02 0.0075094967
## C0_T2 -3.052908e-02 -5.246276e-02 3.348664e-02 -0.0554572502
## C2_T2 4.425609e-02 -8.922361e-03 -2.945755e-03 -0.0078255954
## C3.OH_T2 1.287496e-03 7.805327e-04 9.359364e-03 0.0029951954
## C6..C4.1.DC._T2 -7.680802e-02 8.104879e-02 8.834765e-02 0.0268625274
## C5.DC..C6.OH._T2 2.851453e-02 4.892637e-02 2.142828e-02 -0.1246763115
## C7.DC_T2 2.445334e-02 -3.904791e-02 1.391596e-01 -0.0078091005
## C8_T2 -6.635091e-04 -8.091426e-03 1.330632e-02 -0.0020952806
## C10_T2 -2.217841e-03 -4.098693e-03 6.820634e-03 -0.0094090812
## C10.1_T2 -2.106094e-03 7.590579e-04 6.609297e-03 0.0031867687
## C10.2_T2 -1.467959e-03 1.036223e-03 6.360983e-03 0.0021386800
## C14.1_T2 1.622729e-03 1.757812e-03 3.946817e-03 0.0017643735
## C14.2_T2 -8.518796e-04 7.026953e-04 3.849890e-03 0.0048342342
## C16.1_T2 -5.563015e-04 1.276138e-03 4.775914e-03 0.0039011183
## C16.2_T2 -7.623318e-04 2.703099e-03 3.908874e-03 0.0055918800
## C16.2.OH_T2 -7.696037e-04 2.415227e-03 3.601662e-03 0.0071768503
## C18.1_T2 1.469156e-03 4.629146e-03 1.945267e-03 0.0061236936
## C18.1.OH_T2 -3.174461e-04 1.289509e-03 4.215547e-03 0.0063532258
## C18.2_T2 5.940853e-04 -1.934315e-03 4.137495e-03 0.0071486699
## lysoPC.a.C14.0_T2 6.803812e-03 -8.090128e-02 -4.503701e-02 -0.0231883311
## lysoPC.a.C16.0_T2 -3.701925e-02 -9.423080e-03 -6.847138e-02 -0.0370137903
## lysoPC.a.C16.1_T2 -5.372858e-02 -2.339875e-03 -1.889563e-02 -0.0130883092
## lysoPC.a.C17.0_T2 -1.436626e-02 -3.248140e-03 -1.094789e-02 0.0075703485
## lysoPC.a.C18.0_T2 -2.098959e-02 -5.391135e-03 -2.694524e-02 -0.0300965114
## lysoPC.a.C18.1_T2 5.153069e-02 2.443475e-03 -4.721459e-02 -0.0657606887
## lysoPC.a.C18.2_T2 -5.745338e-03 -3.638285e-02 -5.629656e-02 0.0184781806
## lysoPC.a.C20.3_T2 3.459489e-02 3.546131e-02 1.523237e-03 -0.0426790672
## lysoPC.a.C20.4_T2 5.167493e-02 3.759927e-02 -6.804761e-02 -0.0969485815
## lysoPC.a.C24.0_T2 -4.386681e-03 3.879069e-03 4.846344e-03 -0.0021809560
## lysoPC.a.C26.0_T2 -5.954251e-02 3.745744e-02 -6.116975e-02 -0.0332570654
## lysoPC.a.C26.1_T2 -4.402748e-03 5.526351e-03 1.698182e-03 -0.0040603922
## lysoPC.a.C28.0_T2 3.212886e-02 8.140669e-02 -1.057765e-02 -0.1420366497
## lysoPC.a.C28.1_T2 -6.352877e-03 1.145286e-02 -2.009197e-03 -0.0042693780
## PC.aa.C24.0_T2 6.322546e-02 4.430853e-02 -3.375443e-02 -0.1611950298
## PC.aa.C28.1_T2 -1.938914e-02 -1.467351e-02 2.126706e-03 0.0044635550
## PC.aa.C30.0_T2 -1.179557e-02 -1.217926e-02 -1.044601e-03 0.0164795979
## PC.aa.C32.0_T2 -2.013819e-02 -8.895564e-03 3.510552e-02 0.0127174866
## PC.aa.C32.1_T2 -7.375952e-02 -1.513784e-02 -2.266809e-02 -0.0181123749
## PC.aa.C32.3_T2 -4.557442e-03 6.232130e-03 1.571862e-03 0.0048479034
## PC.aa.C34.1_T2 3.576762e-03 4.945200e-03 4.156478e-02 -0.0382652513
## PC.aa.C34.2_T2 -7.926799e-02 -2.980601e-02 9.868852e-03 0.0590806626
## PC.aa.C34.3_T2 -8.244041e-02 1.024259e-03 2.002537e-02 -0.0031503799
## PC.aa.C34.4_T2 -2.223735e-03 3.477715e-03 5.020362e-03 0.0051846116
## PC.aa.C36.0_T2 -2.369750e-03 1.268301e-02 -2.845645e-03 -0.0003478142
## PC.aa.C36.1_T2 -1.641381e-02 1.274590e-02 7.593331e-02 0.0442317392
## PC.aa.C36.2_T2 -6.692101e-02 -1.686672e-02 2.005941e-02 0.0331721558
## PC.aa.C36.3_T2 -6.038746e-02 4.854008e-02 4.816142e-02 0.0028888238
## PC.aa.C36.4_T2 -2.423422e-02 6.600755e-02 2.668116e-02 -0.0783385531
## PC.aa.C36.5_T2 8.177455e-03 -2.987802e-02 -2.744422e-02 0.0328467475
## PC.aa.C38.0_T2 4.486381e-03 4.297527e-03 1.346417e-02 0.0072223082
## PC.aa.C38.1_T2 4.176888e-03 4.362837e-02 -4.630653e-02 0.0325082637
## PC.aa.C38.3_T2 -2.108277e-02 3.390138e-02 3.620842e-02 -0.0587140879
## PC.aa.C38.4_T2 -1.930091e-02 1.507074e-02 -1.199089e-03 -0.0949230028
## PC.aa.C38.5_T2 -2.710126e-02 -1.785946e-02 2.745041e-03 -0.0647733528
## PC.aa.C38.6_T2 -5.814953e-02 -1.555811e-02 7.543406e-03 -0.0631151153
## PC.aa.C40.1_T2 6.523215e-02 -7.264122e-03 7.110316e-02 0.0745539535
## PC.aa.C40.2_T2 -2.180065e-03 2.131241e-02 -6.923877e-03 -0.0017672892
## PC.aa.C40.3_T2 -3.149615e-03 2.052013e-02 -1.099408e-03 -0.0042131015
## PC.aa.C40.4_T2 -1.556660e-02 2.378500e-03 1.631785e-02 -0.0127573741
## PC.aa.C40.5_T2 -3.277791e-02 -1.614803e-02 1.431656e-02 -0.0228463819
## PC.aa.C40.6_T2 -7.671306e-02 -2.544723e-02 -1.070136e-02 -0.0328447472
## PC.aa.C42.0_T2 -1.184692e-03 2.649861e-03 -3.605943e-03 -0.0014584986
## PC.aa.C42.1_T2 -1.507257e-03 5.771683e-03 -6.311264e-05 0.0012316930
## PC.aa.C42.2_T2 -1.998675e-03 8.105359e-03 -1.643521e-03 0.0037105637
## PC.aa.C42.4_T2 -1.115497e-03 6.336128e-03 7.543580e-04 0.0038326119
## PC.aa.C42.5_T2 -1.751277e-04 4.856493e-03 1.970322e-03 0.0032286153
## PC.aa.C42.6_T2 3.407055e-02 7.616336e-02 -1.718157e-02 -0.0135188090
## PC.ae.C30.0_T2 -7.723492e-02 5.403360e-02 -1.065534e-01 0.0697837733
## PC.ae.C32.1_T2 6.237234e-03 4.968595e-03 3.877524e-03 0.0253393794
## PC.ae.C32.2_T2 -4.923509e-03 5.890310e-03 -8.503143e-04 0.0071969950
## PC.ae.C34.0_T2 -1.434132e-03 1.300537e-03 7.262205e-03 0.0131313594
## PC.ae.C34.1_T2 -8.318771e-03 1.297130e-02 1.995302e-02 0.0238103232
## PC.ae.C34.2_T2 4.836924e-03 4.906140e-03 2.819383e-03 0.0170791886
## PC.ae.C34.3_T2 2.705724e-03 1.199169e-02 -5.090060e-03 -0.0020562300
## PC.ae.C36.0_T2 3.384367e-03 6.456238e-03 1.478141e-02 0.0104596348
## PC.ae.C36.1_T2 -7.228107e-03 5.004675e-02 -8.823947e-03 -0.0175763976
## PC.ae.C36.2_T2 -4.097739e-02 -5.887170e-05 -1.230963e-02 0.0313303297
## PC.ae.C36.3_T2 9.012759e-03 1.119082e-02 4.672158e-03 0.0051662073
## PC.ae.C36.4_T2 -1.779118e-03 8.126459e-04 3.395399e-02 0.0192807828
## PC.ae.C36.5_T2 1.215462e-02 1.259713e-02 3.097793e-02 0.0255529375
## PC.ae.C38.0_T2 -2.180825e-02 -8.235758e-03 -9.692936e-04 0.0018291391
## PC.ae.C38.2_T2 -7.006499e-03 2.814630e-02 -1.787792e-02 0.0166377041
## PC.ae.C38.3_T2 -1.343737e-02 4.683908e-02 -1.094230e-02 -0.0109095092
## PC.ae.C38.4_T2 1.041735e-02 2.470569e-02 2.914182e-02 -0.0060009408
## PC.ae.C38.5_T2 1.457104e-02 9.201464e-03 4.902436e-02 -0.0047561374
## PC.ae.C38.6_T2 -1.563058e-02 1.570798e-02 1.866775e-02 0.0056428757
## PC.ae.C40.1_T2 -4.058653e-03 8.632019e-03 -3.336651e-03 -0.0086592244
## PC.ae.C40.2_T2 -1.397320e-02 1.849790e-02 -2.375493e-03 0.0071456971
## PC.ae.C40.3_T2 -4.621150e-03 2.807497e-02 -1.629327e-02 -0.0025852673
## PC.ae.C40.4_T2 -5.027669e-04 1.765373e-02 -2.669149e-04 -0.0052087820
## PC.ae.C40.5_T2 -8.791269e-04 7.508333e-03 -4.325849e-03 -0.0088893027
## PC.ae.C40.6_T2 -4.236543e-03 3.781812e-04 9.527653e-03 -0.0028663039
## PC.ae.C42.1_T2 -2.215029e-03 2.041789e-02 1.220151e-03 -0.0030558292
## PC.ae.C42.2_T2 -2.110335e-04 8.841618e-03 -3.177140e-03 0.0012895078
## PC.ae.C42.3_T2 -5.185497e-03 3.960469e-03 -5.340424e-03 -0.0001250811
## PC.ae.C42.4_T2 -1.623012e-03 -2.409758e-03 3.263416e-03 0.0024303971
## PC.ae.C42.5_T2 1.202924e-02 -1.091861e-02 -7.109041e-03 -0.0108095499
## PC.ae.C44.3_T2 1.316009e-02 -3.370845e-02 -4.539936e-03 -0.0115199453
## PC.ae.C44.4_T2 2.566196e-03 9.633982e-04 4.271703e-04 0.0044371295
## PC.ae.C44.5_T2 2.186158e-02 -4.127807e-02 -1.360610e-02 -0.0041717718
## PC.ae.C44.6_T2 -1.652568e-04 -1.919990e-02 -1.720654e-02 -0.0037327064
## SM..OH..C14.1_T2 -3.650526e-02 1.492696e-02 -1.666299e-02 0.0210879854
## SM..OH..C16.1_T2 -1.975400e-02 5.277373e-03 -5.144316e-03 0.0119512549
## SM..OH..C22.1_T2 4.162315e-03 -2.455377e-02 2.417644e-03 0.0041008800
## SM..OH..C22.2_T2 -1.878745e-02 4.352088e-03 -2.584616e-02 -0.0132039081
## SM..OH..C24.1_T2 -5.674997e-03 -2.291561e-03 4.195809e-03 0.0111671399
## SM.C16.0_T2 -4.920302e-02 1.695097e-03 1.353241e-02 -0.0217303224
## SM.C16.1_T2 -3.567154e-02 2.097960e-02 -5.100684e-02 -0.0462138625
## SM.C18.0_T2 -1.146853e-01 2.631583e-02 -4.121353e-02 -0.0046123083
## SM.C18.1_T2 -7.457914e-02 2.587863e-02 -8.410673e-02 -0.0332386421
## SM.C20.2_T2 -6.060613e-03 3.535631e-03 -1.326018e-03 0.0077175477
## SM.C24.0_T2 -1.724191e-02 -3.232030e-02 3.490383e-02 -0.0042643587
## SM.C24.1_T2 -4.969681e-02 -2.673997e-02 -1.657483e-04 -0.0308045617
## MEDDM_T4 4.782671e-03 4.716376e-03 5.140205e-03 0.0079096462
## MEDCOL_T4 8.695962e-03 1.132873e-02 -1.675890e-02 0.0150345502
## MEDINF_T4 -9.081027e-04 4.714583e-03 1.121098e-02 0.0200309188
## MEDHTA_T4 5.259192e-03 2.891223e-03 -2.538751e-02 0.0112701013
## GLU_T4 -4.463627e-02 9.156790e-02 -3.587839e-02 -0.0359284893
## INS_T4 -1.269570e-01 6.766797e-02 6.203589e-02 0.1846963255
## HOMA_T4 -5.338236e-02 4.084692e-02 1.423498e-02 0.0640151838
## HBA1C_T4 -3.927332e-03 2.335918e-02 1.842397e-02 -0.0208772330
## HBA1C.mmol.mol_T4 -4.114109e-04 5.286301e-02 4.636535e-02 -0.0715666908
## PESO_T4 2.177502e-02 -3.107971e-02 -1.310314e-02 -0.0073741916
## bmi_T4 2.269799e-02 -1.905624e-02 3.128140e-02 0.0310240860
## CC_T4 -1.748899e-04 4.890503e-03 1.039700e-02 0.0038060158
## CINT_T4 7.169335e-02 -4.503607e-02 -7.565221e-03 0.0372748515
## CAD_T4 2.892002e-02 -1.533444e-02 -3.285460e-02 0.0134064072
## TAD_T4 4.330325e-02 9.391807e-03 -6.667919e-02 0.0061577043
## TAS_T4 2.976380e-02 6.439689e-02 -6.126094e-02 0.0198780016
## TG_T4 -5.468188e-02 -4.062371e-02 -4.458670e-02 -0.0357340204
## COL_T4 2.725478e-02 -2.373873e-02 -6.296225e-03 -0.0449906969
## LDL_T4 3.783804e-02 -2.219554e-02 -4.666023e-03 -0.0036584772
## HDL_T4 6.407029e-02 -9.997140e-03 -1.582140e-02 -0.0937957110
## VLDL_T4 -5.941315e-02 -7.196396e-02 4.757700e-03 -0.0244830002
## PCR_T4 1.231865e-01 -7.841961e-02 -2.317822e-02 0.0705140991
## LEP_T4 4.089542e-02 -2.276415e-02 1.033019e-01 0.0821985137
## ADIPO_T4 1.079087e-03 -2.328511e-02 2.119844e-02 0.0410811936
## GOT_T4 3.490688e-02 7.376572e-02 -6.419714e-02 -0.0973078840
## GPT_T4 -1.683782e-02 2.631425e-02 1.111403e-04 -0.1110012695
## GGT_T4 -3.405185e-03 5.853112e-02 2.518190e-01 -0.0949821740
## URICO_T4 3.069141e-02 -8.183821e-02 -2.334029e-03 0.0001807418
## CREAT_T4 -6.805653e-03 2.807470e-03 -3.554776e-03 -0.0027573625
## UREA_T4 -5.684494e-03 7.531597e-04 1.037383e-02 -0.0911625547
## HIERRO_T4 3.856863e-02 -1.948759e-02 6.531951e-02 -0.0150107394
## TRANSF_T4 -2.371737e-03 -1.071210e-01 1.062154e-01 0.0728046168
## FERR_T4 2.795304e-02 -2.050520e-02 -1.001522e-01 -0.0208526000
## Ile_T4 -6.599218e-02 4.829631e-03 -4.413209e-03 -0.0123536505
## Leu_T4 -8.735445e-02 3.069254e-02 -1.995210e-02 -0.0514758687
## Val_T4 -4.694382e-02 2.584725e-02 9.598329e-03 -0.0140547850
## Ala_T4 -3.382306e-02 -5.948897e-02 -5.017289e-02 0.0526945679
## Pro_T4 -2.600847e-02 -2.870149e-02 -6.675291e-03 0.0350736543
## Gly_T4 -5.016845e-02 2.639476e-02 -3.091378e-02 -0.0225632993
## Ser_T4 6.710656e-02 6.455897e-02 5.908807e-02 -0.0442595247
## Trp_T4 2.212341e-02 1.004609e-02 5.918550e-03 -0.0285454370
## Phe_T4 -2.979167e-02 1.878319e-02 7.607107e-03 -0.0539140239
## Met_T4 -6.548029e-02 -4.510472e-03 8.608013e-03 -0.0068917692
## Orn_T4 6.067697e-02 4.917542e-02 7.311960e-02 -0.0035694299
## Arg_T4 -6.202662e-02 -7.480640e-02 2.503443e-02 0.0630196824
## His_T4 -5.898161e-02 -1.615150e-02 -3.734526e-02 -0.0291528413
## Asn_T4 -1.122411e-02 -8.712497e-03 2.729503e-02 -0.0086609146
## Asp_T4 -1.181088e-01 -1.154564e-01 2.389522e-01 -0.0859156310
## Glu_T4 3.270226e-03 1.028338e-02 5.644548e-02 0.0267126176
## Gln_T4 7.173932e-02 9.916118e-02 -2.712640e-02 -0.0286939451
## Cit_T4 -1.595386e-02 5.423099e-02 3.864010e-04 0.0980877968
## Tyr_T4 -1.329079e-02 -2.054751e-03 5.745343e-03 -0.0391361647
## Thr_T4 -3.173802e-02 -2.650430e-02 5.093517e-02 0.0486170835
## Lys_T4 -7.162791e-03 -4.781387e-02 -1.458812e-02 0.0431618047
## Creatinine_T4 -4.015297e-02 -3.599387e-03 -6.380839e-02 -0.0383869044
## Kynurenine_T4 2.841984e-02 1.118974e-01 -4.468500e-03 0.1801657829
## Putrescine_T4 -4.242641e-02 8.432148e-02 -1.564256e-02 -0.0247173531
## Sarcosine_T4 -8.916247e-02 -5.297631e-02 -3.223404e-02 0.0792041064
## Serotonin_T4 2.458545e-02 1.055879e-01 3.397682e-02 0.1117828535
## Taurine_T4 9.693296e-02 3.188829e-02 4.882934e-02 0.0489096220
## SDMA_T4 1.868387e-03 1.211198e-02 8.186285e-03 0.0060413111
## C0_T4 -4.597886e-02 5.186567e-02 7.498962e-02 -0.0281683998
## C2_T4 -7.066272e-02 8.701931e-02 1.030999e-02 -0.0943430068
## C3.OH_T4 -3.213324e-03 7.632071e-03 9.306951e-03 0.0028103856
## C6..C4.1.DC._T4 5.911302e-02 9.378016e-02 2.626646e-02 0.0237228584
## C5.DC..C6.OH._T4 -2.165011e-02 -6.936770e-02 -6.489522e-03 0.1151802097
## C7.DC_T4 -9.662332e-02 -1.204483e-01 1.291949e-01 -0.0072158090
## C8_T4 -1.295941e-02 5.080057e-03 9.689346e-03 0.0027930813
## C10_T4 -8.806188e-03 1.240695e-03 3.228017e-03 0.0031140466
## C10.1_T4 -4.643128e-03 2.348777e-03 4.382214e-03 0.0063529403
## C10.2_T4 -2.815765e-03 2.254311e-03 5.235627e-03 0.0064031630
## C14.1_T4 -5.565329e-03 3.528273e-03 4.179311e-03 0.0042048575
## C14.2_T4 -4.314390e-03 2.650138e-03 3.898209e-03 0.0070723737
## C16.1_T4 4.396935e-02 -3.943263e-02 8.631091e-02 0.0534711752
## C16.2_T4 -2.387415e-03 3.114819e-03 4.285391e-03 0.0059751157
## C16.2.OH_T4 4.438919e-02 -3.905340e-02 8.588765e-02 0.0545069912
## C18.1_T4 -1.352201e-03 2.221288e-03 3.321842e-03 0.0070751591
## C18.1.OH_T4 -2.193846e-03 3.398243e-03 4.052551e-03 0.0064228014
## C18.2_T4 -2.517465e-03 3.341636e-03 4.067541e-03 0.0060725084
## lysoPC.a.C16.0_T4 -2.298288e-02 2.747877e-02 1.300676e-02 0.0388599309
## lysoPC.a.C16.1_T4 -4.340808e-02 -2.445897e-02 -1.615224e-02 0.0029700374
## lysoPC.a.C17.0_T4 1.107806e-02 7.178495e-03 -1.255418e-02 0.0306054591
## lysoPC.a.C18.0_T4 -2.066928e-02 6.628055e-02 1.262698e-02 0.0862258503
## lysoPC.a.C18.1_T4 -9.118336e-03 -1.931437e-02 -1.799613e-02 0.0639331877
## lysoPC.a.C18.2_T4 -6.322112e-02 -3.850216e-02 -2.575335e-02 0.0331121355
## lysoPC.a.C20.3_T4 -8.878691e-03 -1.117190e-02 -1.429204e-02 0.0090249753
## lysoPC.a.C20.4_T4 -1.077844e-03 7.958515e-03 3.112701e-02 0.0250508783
## lysoPC.a.C24.0_T4 -4.941505e-03 6.570832e-03 6.085754e-03 0.0017864062
## lysoPC.a.C26.0_T4 5.487163e-02 6.621011e-02 1.666054e-03 -0.0510898266
## lysoPC.a.C26.1_T4 -2.623102e-03 5.746402e-03 1.040445e-02 -0.0032015872
## lysoPC.a.C28.0_T4 1.265323e-02 8.067463e-02 7.708868e-02 -0.0277202180
## lysoPC.a.C28.1_T4 9.332290e-04 3.768660e-03 4.229505e-03 0.0031439114
## PC.aa.C24.0_T4 2.829896e-02 -1.770496e-02 9.330993e-03 -0.1541844678
## PC.aa.C28.1_T4 1.489835e-02 9.905481e-05 5.181694e-03 -0.0114773266
## PC.aa.C30.0_T4 7.692463e-03 -1.962786e-02 1.229011e-02 -0.0126414720
## PC.aa.C32.0_T4 5.106322e-02 -4.529076e-02 -5.975948e-03 -0.0411297092
## PC.aa.C32.1_T4 -5.754990e-03 -1.077884e-01 6.405356e-02 -0.1013910240
## PC.aa.C32.3_T4 6.104595e-04 2.479951e-03 3.234311e-03 0.0058393831
## PC.aa.C34.1_T4 6.925470e-02 -3.763927e-02 5.412103e-02 -0.0387837161
## PC.aa.C34.2_T4 1.570780e-02 -2.434680e-02 1.623389e-02 -0.0401134927
## PC.aa.C34.3_T4 -3.523875e-02 -4.616252e-02 -5.123830e-03 -0.0157298624
## PC.aa.C34.4_T4 1.918708e-04 -3.531950e-03 7.636309e-03 0.0041356972
## PC.aa.C36.0_T4 1.559607e-02 -7.209370e-04 6.399088e-03 0.0092976725
## PC.aa.C36.1_T4 5.266121e-02 -3.594932e-03 3.179380e-02 0.0092643951
## PC.aa.C36.2_T4 1.514323e-02 1.024480e-02 2.453395e-02 0.0167975105
## PC.aa.C36.3_T4 8.471486e-03 -5.976314e-03 -6.396900e-02 -0.0096184553
## PC.aa.C36.4_T4 4.184770e-02 2.394290e-02 4.147932e-02 -0.0307961794
## PC.aa.C36.5_T4 1.533387e-02 -7.071836e-02 5.169092e-02 -0.0435907994
## PC.aa.C38.0_T4 4.304036e-02 -1.329687e-02 1.726561e-02 -0.0017508235
## PC.aa.C38.1_T4 2.313971e-02 -8.867637e-03 1.456353e-02 -0.0096924108
## PC.aa.C38.3_T4 1.712325e-02 -3.005174e-02 -6.154575e-02 -0.0115189725
## PC.aa.C38.4_T4 4.356033e-02 3.146010e-02 5.634811e-02 -0.0205778399
## PC.aa.C38.5_T4 2.320561e-03 -1.771780e-02 3.051391e-02 -0.0403356832
## PC.aa.C38.6_T4 4.649171e-02 -5.938191e-02 7.532861e-02 -0.0555584693
## PC.aa.C40.1_T4 1.320841e-01 2.868216e-02 2.398573e-02 -0.0736924448
## PC.aa.C40.2_T4 3.184667e-03 1.476429e-03 -2.047353e-03 0.0081055947
## PC.aa.C40.3_T4 4.271214e-03 3.729163e-03 -7.708800e-04 0.0084328988
## PC.aa.C40.4_T4 -2.204919e-02 -3.331962e-03 2.417183e-02 -0.0077377122
## PC.aa.C40.5_T4 -2.299849e-02 -5.634706e-03 1.691762e-02 -0.0309034301
## PC.aa.C40.6_T4 2.000840e-02 -4.842347e-02 5.622556e-02 -0.0155328996
## PC.aa.C42.0_T4 5.924360e-03 -4.779479e-03 2.434736e-03 -0.0002313004
## PC.aa.C42.1_T4 3.748863e-03 2.993620e-04 8.391006e-04 0.0039439321
## PC.aa.C42.2_T4 -4.937252e-05 1.276476e-03 5.450458e-03 0.0059963805
## PC.aa.C42.4_T4 -3.971156e-04 3.990345e-03 2.583477e-03 0.0044442398
## PC.aa.C42.5_T4 -1.756861e-05 -2.793080e-04 6.212867e-03 0.0038005231
## PC.aa.C42.6_T4 5.950238e-02 -3.872319e-02 -8.181380e-02 -0.0360062520
## PC.ae.C30.0_T4 4.724041e-02 5.834844e-02 -6.315106e-02 -0.0886766510
## PC.ae.C32.1_T4 1.795737e-02 -7.385878e-04 5.503691e-03 -0.0103424751
## PC.ae.C32.2_T4 3.144257e-03 3.335115e-03 6.640222e-03 0.0015220793
## PC.ae.C34.0_T4 6.313407e-03 -9.887752e-04 2.784002e-03 0.0031634489
## PC.ae.C34.1_T4 5.775790e-02 -1.599711e-02 -2.674339e-02 -0.0268347044
## PC.ae.C34.2_T4 4.787880e-02 -1.415214e-02 -4.222458e-03 -0.0203485417
## PC.ae.C34.3_T4 4.407231e-02 1.489554e-02 4.536599e-03 -0.0177330733
## PC.ae.C36.0_T4 6.377251e-03 4.172809e-03 9.522905e-03 0.0103735629
## PC.ae.C36.1_T4 1.934705e-02 -1.516440e-03 -1.525456e-02 -0.0023666017
## PC.ae.C36.2_T4 4.130574e-02 -6.043871e-03 -3.525121e-02 -0.0160326780
## PC.ae.C36.3_T4 2.513686e-02 -6.644258e-04 -1.007524e-02 -0.0153048808
## PC.ae.C36.4_T4 3.300478e-02 2.101007e-02 9.954719e-03 -0.0469947202
## PC.ae.C36.5_T4 6.506393e-02 3.108003e-02 2.612297e-02 0.0175121224
## PC.ae.C38.0_T4 -1.061625e-03 -1.301439e-02 2.001529e-02 -0.0065272378
## PC.ae.C38.2_T4 1.233567e-02 -7.145998e-03 -7.546513e-03 0.0056078674
## PC.ae.C38.3_T4 1.815383e-02 2.897031e-03 -2.831737e-02 0.0085014299
## PC.ae.C38.4_T4 5.452170e-02 1.923919e-02 -1.240333e-02 -0.0157969078
## PC.ae.C38.5_T4 4.363109e-02 2.246513e-02 -7.862893e-03 -0.0092615749
## PC.ae.C38.6_T4 3.664669e-02 1.236489e-02 5.112273e-03 0.0058186566
## PC.ae.C40.1_T4 2.265279e-03 2.541712e-03 1.226559e-02 0.0005718180
## PC.ae.C40.2_T4 2.699756e-02 -6.653917e-03 -1.961616e-02 0.0081096515
## PC.ae.C40.3_T4 1.789768e-02 -5.054063e-03 -1.147818e-02 0.0063058664
## PC.ae.C40.4_T4 2.043756e-02 -5.243066e-03 -2.878021e-03 -0.0062419091
## PC.ae.C40.5_T4 -1.324376e-04 -1.728638e-03 -5.152203e-03 -0.0190118366
## PC.ae.C40.6_T4 1.304306e-02 -2.672310e-03 6.082923e-03 -0.0140233994
## PC.ae.C42.1_T4 2.105964e-03 2.762286e-03 -1.079573e-04 0.0091414879
## PC.ae.C42.2_T4 6.885076e-03 -3.325036e-03 -3.417400e-03 0.0045052069
## PC.ae.C42.3_T4 -1.295261e-04 -1.284316e-03 2.373171e-03 -0.0040239643
## PC.ae.C42.4_T4 2.582164e-03 -2.917155e-03 1.272745e-03 -0.0087685925
## PC.ae.C42.5_T4 1.353818e-02 -1.027434e-02 -1.141230e-02 -0.0218258121
## PC.ae.C44.3_T4 -1.483547e-03 2.419682e-03 3.434879e-03 0.0060804853
## PC.ae.C44.4_T4 1.617966e-03 -8.990964e-04 1.523021e-03 0.0009901088
## PC.ae.C44.5_T4 8.375825e-03 -1.433421e-02 -1.446361e-02 -0.0294125468
## PC.ae.C44.6_T4 5.938996e-03 -9.680259e-03 -3.407703e-03 -0.0150230962
## SM..OH..C14.1_T4 3.311171e-02 2.586297e-02 -2.646339e-02 -0.0094345947
## SM..OH..C16.1_T4 2.192889e-02 1.319694e-02 -1.103629e-02 0.0087253857
## SM..OH..C22.1_T4 1.526934e-02 2.418490e-02 2.134656e-02 0.0124647716
## SM..OH..C22.2_T4 4.136788e-02 1.048579e-02 -4.565778e-02 0.0057622026
## SM..OH..C24.1_T4 2.622983e-03 4.574886e-03 1.251171e-03 0.0131208373
## SM.C16.0_T4 4.388225e-02 4.336737e-02 -5.336043e-03 0.0004064156
## SM.C16.1_T4 2.652389e-02 4.277011e-02 2.215265e-02 -0.0206510972
## SM.C18.0_T4 4.526235e-02 1.916326e-02 -8.205843e-02 0.0197404688
## SM.C18.1_T4 2.223738e-02 7.535450e-04 -6.494792e-02 0.0041886599
## SM.C20.2_T4 1.126141e-04 1.160264e-03 1.297424e-03 0.0094171241
## SM.C24.0_T4 8.973638e-03 5.544327e-02 6.649922e-02 -0.0246293353
## SM.C24.1_T4 2.990172e-02 -3.124843e-02 -9.690472e-02 -0.0053719105
## MEDDM_T5 -1.951234e-02 -8.207121e-03 -4.153529e-03 -0.0156086818
## MEDCOL_T5 -1.951234e-02 -8.207121e-03 -4.153529e-03 -0.0156086818
## MEDINF_T5 -1.868307e-02 -6.961066e-03 2.287041e-03 -0.0028686707
## MEDHTA_T5 -1.356211e-02 -6.800016e-03 -2.350989e-03 -0.0144375490
## GLU_T5 3.946821e-02 -4.802696e-03 -1.042177e-02 -0.0381152571
## INS_T5 -5.403671e-02 3.782656e-02 -4.809892e-02 -0.0295899402
## HOMA_T5 -1.671496e-02 1.677707e-02 -2.153630e-02 -0.0037237445
## HBA1C_T5 -6.076932e-03 2.139274e-02 1.784360e-02 -0.0088492886
## HBA1C.mmol.mol_T5 -7.792253e-03 4.662813e-02 4.484782e-02 -0.0311411373
## PESO_T5 4.736569e-03 -3.052931e-02 3.594963e-02 -0.0523119517
## bmi_T5 9.329127e-03 -1.719303e-02 6.750128e-02 -0.0154212332
## CC_T5 -1.558960e-03 -5.760133e-04 4.474557e-03 0.0046524932
## CINT_T5 6.083968e-02 -3.264689e-02 5.766488e-02 -0.0355488467
## CAD_T5 2.429637e-02 2.813279e-02 5.188585e-03 -0.0295253893
## TAD_T5 -3.243004e-02 -7.434635e-02 -2.956070e-02 0.0091575818
## TAS_T5 3.774555e-02 1.650555e-02 -2.905747e-02 0.0730203455
## TG_T5 -3.738079e-03 6.925571e-03 -5.959140e-02 0.0045283635
## COL_T5 5.282862e-02 -4.616577e-02 -1.087088e-02 0.0628982154
## LDL_T5 5.198142e-02 -4.863785e-02 -1.863269e-02 0.0877373669
## HDL_T5 8.131053e-02 -3.130796e-02 3.233920e-02 0.0096667718
## VLDL_T5 3.503331e-03 -1.758739e-02 5.584311e-02 -0.0491355395
## PCR_T5 3.114229e-02 -4.433540e-02 2.100436e-02 0.0138540737
## LEP_T5 -5.249479e-02 8.124460e-02 -1.041466e-02 -0.0433616936
## ADIPO_T5 -2.950497e-02 -1.190458e-02 1.676287e-02 0.0232770295
## GOT_T5 7.276997e-02 9.452310e-02 2.475117e-02 0.0183285589
## GPT_T5 -2.553337e-02 1.940762e-02 -3.952059e-02 -0.0708541822
## GGT_T5 2.807282e-02 1.912275e-02 -1.366991e-02 0.0761187766
## URICO_T5 2.219095e-02 -4.160329e-02 -3.250279e-03 -0.0205723089
## CREAT_T5 -2.215261e-03 -8.419458e-04 1.916961e-03 0.0023261313
## UREA_T5 -2.596994e-03 2.494744e-02 6.771487e-03 0.0371478339
## HIERRO_T5 -1.007001e-01 4.658165e-03 -1.253491e-02 -0.0880194608
## TRANSF_T5 6.747244e-02 -2.610538e-02 -5.584282e-02 0.0045333196
## FERR_T5 -1.038696e-01 -1.296639e-01 -2.118846e-02 -0.0630443827
## Ile_T5 1.610163e-02 2.595617e-03 4.898517e-02 -0.0425873876
## Leu_T5 -2.530749e-03 3.277011e-02 4.300272e-02 0.0046225504
## Val_T5 -5.339700e-03 7.318794e-02 6.862467e-02 0.0313137996
## Ala_T5 4.028891e-02 3.040108e-02 2.376156e-02 -0.0445480064
## Pro_T5 3.763420e-02 -7.544109e-02 -6.231861e-02 -0.0405490935
## Gly_T5 -6.485603e-02 -3.008629e-02 -3.401015e-02 -0.0162873306
## Ser_T5 2.903794e-02 4.666751e-02 6.165543e-02 0.0396398125
## Trp_T5 1.867824e-02 -3.447721e-02 2.561649e-02 0.0002255213
## Phe_T5 2.220562e-02 6.861859e-02 4.700623e-02 0.0343014228
## Met_T5 8.715455e-03 -1.809027e-02 -2.843251e-02 -0.0436760298
## Orn_T5 3.981184e-02 6.320280e-02 6.258431e-03 0.0988599883
## Arg_T5 4.581244e-03 -3.843742e-02 2.654730e-02 0.0293731169
## His_T5 -1.600109e-02 -1.537728e-02 5.293467e-03 -0.0583977571
## Asn_T5 3.358144e-02 9.943625e-02 4.756919e-02 0.0009314317
## Asp_T5 3.275578e-02 -3.117968e-02 1.448840e-02 -0.0237653182
## Glu_T5 3.359622e-02 -8.992682e-03 -1.026237e-02 -0.0029724020
## Gln_T5 1.130185e-02 6.175865e-02 4.834133e-02 0.0506231254
## Cit_T5 2.666782e-02 6.193977e-02 7.907580e-02 0.0301333641
## Tyr_T5 5.708586e-04 7.175630e-02 -4.856447e-03 0.0198390957
## Thr_T5 8.078216e-02 -3.389766e-03 1.403428e-02 0.0276615041
## Lys_T5 -4.438248e-02 -9.988350e-03 2.286946e-02 -0.0049319073
## Creatinine_T5 -1.040740e-02 -9.746686e-02 3.053278e-02 -0.0659348769
## Kynurenine_T5 5.357051e-02 -4.245351e-02 7.562798e-03 -0.0003737743
## Putrescine_T5 -7.930807e-02 8.163882e-02 2.557913e-02 -0.1098140986
## Sarcosine_T5 7.133715e-02 -4.178248e-02 6.437529e-02 -0.0351813985
## Serotonin_T5 -7.494266e-03 6.394592e-02 5.898545e-02 0.0252973618
## Taurine_T5 2.718955e-02 1.339329e-01 3.510970e-03 0.0421145742
## SDMA_T5 4.409964e-03 4.272004e-03 7.454199e-03 0.0050330628
## C0_T5 5.251697e-02 -6.416533e-02 5.117764e-02 0.0267527657
## C2_T5 -4.653689e-02 -5.445559e-02 2.556095e-02 -0.0473709465
## C3.OH_T5 -4.447206e-03 3.874340e-03 4.671745e-03 0.0087084823
## C6..C4.1.DC._T5 6.642830e-02 2.947613e-02 2.203041e-02 -0.0110694876
## C5.DC..C6.OH._T5 -4.870542e-03 3.527643e-02 3.211865e-02 0.0170105021
## C7.DC_T5 1.485055e-03 -9.261915e-03 6.553088e-02 0.0173169250
## C8_T5 -1.625243e-03 -6.736885e-03 7.070674e-03 0.0133978855
## C10_T5 5.154824e-03 -1.434338e-02 8.091104e-03 0.0154467679
## C10.1_T5 -7.731294e-03 -1.971478e-02 -3.160473e-02 0.0298482628
## C10.2_T5 -4.159456e-04 2.413277e-03 4.565591e-03 0.0086415822
## C14.1_T5 -1.612350e-03 6.121135e-04 3.664097e-03 0.0076326494
## C14.2_T5 -1.430954e-03 3.073952e-03 4.036919e-03 0.0072088125
## C16.1_T5 -1.224667e-03 2.779140e-03 3.986755e-03 0.0068393469
## C16.2_T5 -8.426395e-04 3.291389e-03 3.750417e-03 0.0068032104
## C16.2.OH_T5 4.742613e-02 8.299535e-03 5.488433e-02 0.0463133290
## C18.1_T5 -7.139879e-05 2.414605e-03 4.228214e-03 0.0074772786
## C18.1.OH_T5 -1.226563e-03 3.346488e-03 3.534835e-03 0.0067988236
## C18.2_T5 -1.012641e-03 2.348409e-03 3.785005e-03 0.0071144103
## lysoPC.a.C16.0_T5 -1.560102e-02 -4.643606e-02 -6.266336e-03 -0.0360023737
## lysoPC.a.C16.1_T5 -5.871953e-02 2.590056e-04 1.449541e-03 -0.0252997532
## lysoPC.a.C17.0_T5 -1.041207e-02 2.251778e-03 -1.222677e-02 -0.0058640599
## lysoPC.a.C18.0_T5 -2.928823e-02 -2.436167e-02 -5.352653e-02 -0.0321562139
## lysoPC.a.C18.1_T5 2.888867e-02 -5.031650e-02 7.048866e-03 -0.0434527612
## lysoPC.a.C18.2_T5 2.821315e-02 -6.192426e-02 -1.228401e-02 -0.0221897567
## lysoPC.a.C20.3_T5 -7.303201e-03 3.755614e-02 -9.194248e-04 -0.0014640805
## lysoPC.a.C20.4_T5 2.739976e-02 6.335188e-03 2.883390e-03 -0.0477624224
## lysoPC.a.C24.0_T5 -6.350340e-03 9.959026e-04 3.769123e-03 0.0069317650
## lysoPC.a.C26.0_T5 -1.070209e-02 3.094969e-03 5.139474e-03 0.0027131364
## lysoPC.a.C26.1_T5 -7.655332e-03 5.292386e-03 3.990866e-03 0.0011751471
## lysoPC.a.C28.0_T5 1.145362e-02 -8.275785e-02 -2.546492e-02 0.0009225350
## lysoPC.a.C28.1_T5 -5.518785e-03 3.543462e-03 3.277646e-03 0.0032305922
## PC.aa.C24.0_T5 -2.215582e-02 3.452784e-02 -4.064786e-02 0.0527169404
## PC.aa.C28.1_T5 1.003732e-02 1.429493e-02 1.488456e-02 0.0208947428
## PC.aa.C30.0_T5 -1.656189e-03 1.624257e-02 1.016356e-02 0.0019092628
## PC.aa.C32.0_T5 -4.258002e-03 -3.537116e-03 -9.659442e-03 0.0247571241
## PC.aa.C32.1_T5 -9.415764e-02 2.821417e-02 -2.192053e-02 -0.0221940155
## PC.aa.C32.3_T5 -1.334080e-03 3.036087e-03 3.279295e-03 0.0076317350
## PC.aa.C34.1_T5 -4.035809e-03 8.579751e-03 1.740743e-02 0.0024905468
## PC.aa.C34.2_T5 -2.205376e-02 -6.876762e-03 -1.434340e-02 0.0244750494
## PC.aa.C34.3_T5 -7.700126e-02 2.706427e-02 -1.129760e-02 0.0174501584
## PC.aa.C34.4_T5 6.926877e-04 6.780362e-03 4.224574e-03 0.0067149556
## PC.aa.C36.0_T5 -3.428815e-03 8.597170e-04 8.050801e-03 0.0125797879
## PC.aa.C36.1_T5 1.597105e-02 5.379667e-02 -2.280386e-02 0.0543039854
## PC.aa.C36.2_T5 -2.942839e-02 1.516450e-02 -4.994867e-02 0.0347464075
## PC.aa.C36.3_T5 -3.290151e-02 4.679298e-02 -1.612874e-02 0.0178454832
## PC.aa.C36.4_T5 1.021270e-03 5.683709e-02 -8.535486e-03 -0.0264402049
## PC.aa.C36.5_T5 5.649046e-02 5.738581e-02 7.342387e-02 -0.0317865198
## PC.aa.C38.0_T5 3.108422e-02 -9.270502e-03 1.973415e-02 0.0077358761
## PC.aa.C38.1_T5 -1.092815e-02 7.194315e-04 -5.938916e-03 0.0020006156
## PC.aa.C38.3_T5 -7.324561e-03 5.448871e-02 -2.548073e-02 0.0263232748
## PC.aa.C38.4_T5 -5.005340e-02 5.700526e-02 -5.202469e-02 -0.0216735175
## PC.aa.C38.5_T5 -5.522005e-02 3.576027e-02 3.382943e-04 -0.0142595971
## PC.aa.C38.6_T5 1.446986e-02 3.921851e-03 6.062599e-02 0.0027046772
## PC.aa.C40.1_T5 5.022146e-02 -1.044588e-01 -4.172798e-02 0.0727427118
## PC.aa.C40.2_T5 -5.298059e-03 5.553925e-04 1.999775e-03 0.0055852235
## PC.aa.C40.3_T5 -1.333607e-02 1.841798e-03 -2.682183e-04 0.0039566332
## PC.aa.C40.4_T5 -4.380266e-02 1.132430e-05 -1.715984e-02 -0.0049797072
## PC.aa.C40.5_T5 -7.594313e-02 2.046833e-02 -2.595680e-02 -0.0132371786
## PC.aa.C40.6_T5 -2.781192e-02 -1.861366e-03 6.286795e-03 -0.0299499986
## PC.aa.C42.0_T5 5.642994e-03 -1.011990e-03 7.420265e-04 0.0029467229
## PC.aa.C42.1_T5 1.786022e-03 -1.032878e-03 2.663847e-03 0.0039339991
## PC.aa.C42.2_T5 -2.540146e-03 1.235731e-03 3.699792e-03 0.0060355801
## PC.aa.C42.4_T5 -5.126152e-03 2.466337e-03 1.220442e-03 0.0051508865
## PC.aa.C42.5_T5 -1.663036e-03 4.733873e-03 3.235359e-03 0.0064022044
## PC.aa.C42.6_T5 -5.186381e-02 9.733158e-02 -7.545197e-03 -0.0686448300
## PC.ae.C30.0_T5 9.443831e-03 -3.121534e-02 7.361250e-03 -0.0075923532
## PC.ae.C32.1_T5 1.670762e-02 -4.703480e-03 5.786321e-03 0.0155358846
## PC.ae.C32.2_T5 5.093396e-04 2.587079e-03 3.251630e-03 0.0103826401
## PC.ae.C34.0_T5 4.113138e-04 5.652505e-03 2.891093e-03 0.0123297328
## PC.ae.C34.1_T5 8.869211e-03 -5.543438e-03 -1.807472e-04 0.0209097783
## PC.ae.C34.2_T5 2.309301e-02 -1.887689e-02 -1.138846e-02 0.0311947413
## PC.ae.C34.3_T5 3.349193e-02 -2.645513e-02 -3.047242e-02 0.0256711070
## PC.ae.C36.0_T5 1.886787e-03 -1.715094e-03 7.173019e-03 0.0075120437
## PC.ae.C36.1_T5 -1.553113e-02 1.773331e-02 -6.512865e-03 0.0103540672
## PC.ae.C36.2_T5 -3.695870e-02 3.096609e-02 -2.759611e-02 0.0349470130
## PC.ae.C36.3_T5 4.662992e-03 -6.567343e-03 -1.864416e-02 0.0058276934
## PC.ae.C36.4_T5 2.606341e-02 3.498618e-02 2.991461e-03 -0.0014454987
## PC.ae.C36.5_T5 3.988716e-02 4.979851e-02 1.378634e-03 0.0179328991
## PC.ae.C38.0_T5 3.513271e-03 6.281925e-03 1.553243e-02 0.0093009515
## PC.ae.C38.2_T5 -2.936001e-02 -1.571018e-02 -1.427085e-02 0.0042986752
## PC.ae.C38.3_T5 6.513330e-03 1.076728e-02 -1.728209e-02 0.0108998884
## PC.ae.C38.4_T5 6.669782e-03 1.145001e-02 -2.726235e-02 0.0005438090
## PC.ae.C38.5_T5 5.887094e-02 2.248913e-02 4.970097e-03 0.0027936943
## PC.ae.C38.6_T5 1.877782e-02 3.331856e-02 1.653327e-02 0.0180900226
## PC.ae.C40.1_T5 -2.766885e-03 4.098203e-03 4.624606e-03 0.0039213734
## PC.ae.C40.2_T5 3.826788e-03 1.330901e-02 4.301617e-03 0.0125709721
## PC.ae.C40.3_T5 1.417178e-02 3.531728e-03 -9.681379e-03 0.0099391470
## PC.ae.C40.4_T5 1.452210e-02 -6.815480e-03 -8.323399e-03 0.0034308992
## PC.ae.C40.5_T5 1.889716e-02 -3.560045e-03 -1.467776e-02 -0.0076047843
## PC.ae.C40.6_T5 1.274414e-02 1.663091e-02 6.724663e-03 -0.0020651831
## PC.ae.C42.1_T5 -6.852732e-03 3.567714e-03 1.292205e-03 0.0034874138
## PC.ae.C42.2_T5 -3.738299e-03 -1.445115e-03 2.383150e-03 0.0043191104
## PC.ae.C42.3_T5 -5.470794e-04 -4.983544e-03 2.220554e-03 0.0036125439
## PC.ae.C42.4_T5 2.935018e-03 -2.961872e-03 -1.055659e-03 0.0033645499
## PC.ae.C42.5_T5 3.116598e-02 -2.427286e-02 -1.501583e-02 -0.0082605975
## PC.ae.C44.3_T5 -3.601655e-03 2.814104e-03 2.964487e-03 0.0062040463
## PC.ae.C44.4_T5 2.779208e-04 -2.349325e-03 2.738519e-04 0.0054390647
## PC.ae.C44.5_T5 2.178200e-02 -2.718235e-02 -1.080540e-02 -0.0105922839
## PC.ae.C44.6_T5 2.040884e-02 -1.754755e-02 -9.514237e-03 0.0017289749
## SM..OH..C14.1_T5 -1.737289e-02 1.237569e-03 -3.730687e-03 0.0333877246
## SM..OH..C16.1_T5 -5.378404e-04 1.426684e-02 3.062563e-03 0.0118854174
## SM..OH..C22.1_T5 -8.186528e-03 -1.765717e-02 9.953084e-03 0.0061099224
## SM..OH..C22.2_T5 -1.070244e-03 -2.494113e-02 7.257452e-03 -0.0060721008
## SM..OH..C24.1_T5 2.149863e-03 2.185020e-03 7.390468e-03 0.0062197639
## SM.C16.0_T5 1.116043e-02 -2.498311e-02 2.465440e-02 0.0090531706
## SM.C16.1_T5 1.421905e-02 -6.718143e-02 3.883380e-02 0.0327183130
## SM.C18.0_T5 -1.158250e-02 2.560164e-02 1.429141e-02 0.0055773141
## SM.C18.1_T5 1.060906e-02 -5.203994e-02 1.498737e-02 0.0016753254
## SM.C20.2_T5 -9.491492e-04 3.264879e-03 5.165943e-03 0.0053456626
## SM.C24.0_T5 8.722345e-03 -2.038496e-02 1.822526e-02 -0.0203866694
## SM.C24.1_T5 5.817849e-03 -4.096767e-03 1.698872e-02 -0.0424047647
## PC33 PC34 PC35 PC36
## GLU_T0 6.177124e-02 1.848829e-02 -1.999718e-02 3.080806e-02
## INS_T0 4.723905e-02 -4.426324e-02 -6.465216e-02 -1.210623e-02
## HOMA_T0 5.368581e-02 -9.354879e-03 -5.642162e-02 6.099241e-03
## HBA1C_T0 1.231277e-02 1.544559e-02 3.740204e-03 -2.095100e-02
## HBA1C.mmol.mol_T0 4.656617e-02 5.305374e-02 1.466323e-02 -6.875341e-02
## PESO_T0 6.084033e-02 -4.924924e-02 1.798927e-02 -2.325212e-02
## bmi_T0 5.541750e-02 -3.298134e-02 6.981953e-02 -8.318558e-03
## CC_T0 1.725854e-03 2.058850e-03 -7.255085e-03 -1.058908e-02
## CINT_T0 -2.198962e-02 -3.024485e-02 1.294208e-02 3.282199e-03
## CAD_T0 -1.168879e-02 -7.669047e-02 5.918786e-02 8.714827e-02
## TAD_T0 4.282167e-02 -2.549713e-02 2.923758e-02 -2.841685e-02
## TAS_T0 2.108556e-03 -7.418195e-03 4.115130e-02 -2.897735e-02
## TG_T0 2.588383e-02 6.162383e-03 2.001644e-02 -5.812408e-02
## COL_T0 1.983791e-02 -5.442365e-02 -4.951490e-02 3.563796e-02
## LDL_T0 2.722663e-02 -5.329484e-02 -8.303394e-02 7.697031e-02
## HDL_T0 2.255403e-02 -2.850080e-02 1.509587e-02 -7.474411e-03
## VLDL_T0 2.654905e-02 5.696446e-03 1.990912e-02 -5.818764e-02
## PCR_T0 -4.722453e-02 -5.229116e-02 -2.793291e-02 -3.187893e-03
## LEP_T0 -1.177368e-03 -3.497020e-02 1.940814e-02 -8.283001e-02
## ADIPO_T0 1.240905e-01 -4.092625e-02 -4.577634e-02 -3.212452e-03
## GOT_T0 8.870581e-02 -1.792707e-02 -1.274652e-02 1.034922e-01
## GPT_T0 1.042104e-01 4.855244e-02 5.323874e-02 3.385149e-02
## GGT_T0 9.710785e-03 2.524834e-02 -1.156062e-01 -8.576441e-03
## URICO_T0 -3.971577e-02 -5.652338e-02 -7.131310e-02 5.686408e-03
## CREAT_T0 4.597339e-03 -7.229208e-03 1.878814e-03 -1.232149e-03
## UREA_T0 4.197489e-02 -1.270442e-01 2.747996e-02 -5.667680e-02
## HIERRO_T0 -1.049618e-01 4.280814e-02 -6.547743e-02 -7.632146e-02
## TRANSF_T0 -4.209756e-02 5.024745e-02 7.437484e-03 1.302239e-02
## FERR_T0 4.931887e-02 -2.447155e-02 -9.001433e-02 4.279263e-02
## Ile_T0 -1.557843e-02 -8.290918e-03 3.230823e-02 4.679338e-02
## Leu_T0 -9.252646e-02 4.713734e-02 -1.216784e-02 5.002403e-02
## Val_T0 -2.640394e-02 6.219378e-02 2.376394e-02 7.642563e-03
## Ala_T0 -1.264750e-02 -9.969321e-02 -6.444632e-02 1.343997e-04
## Pro_T0 7.301387e-02 1.765965e-02 1.117267e-01 -1.517798e-02
## Gly_T0 2.103665e-03 3.215125e-02 -4.961049e-02 -3.075851e-02
## Ser_T0 3.064333e-02 2.632949e-02 -4.107496e-02 -1.673735e-02
## Trp_T0 -2.898190e-02 2.750632e-03 7.850388e-02 3.294681e-02
## Phe_T0 -4.497471e-03 1.240967e-02 1.525337e-02 -6.324090e-03
## Met_T0 -2.692811e-03 -1.769305e-02 -3.047385e-02 2.557179e-02
## Orn_T0 4.755048e-02 3.669016e-03 6.826804e-02 2.720700e-02
## Arg_T0 5.463524e-02 -1.226894e-02 -1.748792e-02 -9.163377e-03
## His_T0 -9.819820e-03 -6.826933e-02 2.065264e-02 2.375738e-02
## Asn_T0 -8.788148e-04 -5.039831e-02 -5.648985e-02 3.568835e-02
## Asp_T0 -2.433261e-03 -1.575308e-03 -3.965222e-02 1.963499e-02
## Glu_T0 1.591033e-02 -2.536409e-03 -2.379968e-02 -2.471632e-02
## Gln_T0 2.286603e-02 6.714870e-02 -2.296488e-02 -7.318750e-02
## Cit_T0 2.206265e-02 -1.295856e-01 -2.237554e-02 -3.051934e-02
## Tyr_T0 3.485192e-02 -6.722577e-02 1.010940e-01 -6.520133e-02
## Thr_T0 4.462822e-02 -8.812588e-02 6.550170e-02 -8.145268e-02
## Lys_T0 9.462162e-02 6.920806e-02 5.611503e-02 -8.518370e-02
## Creatinine_T0 7.046319e-02 -2.807934e-02 7.110820e-02 7.724121e-03
## Kynurenine_T0 6.158230e-02 2.157610e-02 4.180384e-02 -2.937582e-02
## Putrescine_T0 1.262800e-01 -1.397757e-02 -1.231080e-01 -7.441364e-02
## Sarcosine_T0 3.116288e-02 5.239484e-02 4.410193e-02 -8.132402e-02
## Serotonin_T0 -7.788962e-02 1.129112e-01 -1.091230e-01 -8.057317e-02
## Taurine_T0 -4.536899e-02 3.720298e-02 -2.123972e-02 -6.664680e-03
## SDMA_T0 -1.677638e-04 1.792789e-03 1.448173e-02 -1.992351e-02
## C0_T0 4.038535e-02 -5.792470e-02 -1.005616e-02 -3.356049e-02
## C2_T0 1.171165e-01 -7.955371e-02 2.799032e-02 -4.013525e-02
## C3.OH_T0 5.656374e-03 -7.083057e-03 -2.633580e-03 4.886923e-03
## C6..C4.1.DC._T0 -1.245313e-02 -9.331689e-02 -9.143165e-02 5.860766e-02
## C5.DC..C6.OH._T0 1.720561e-02 8.794856e-02 -3.591306e-02 1.683146e-02
## C7.DC_T0 1.385245e-01 -4.238119e-03 4.283459e-02 -3.062993e-02
## C8_T0 7.749028e-03 -1.305164e-02 2.522399e-03 -2.925430e-03
## C10_T0 1.760241e-02 -3.705407e-03 -7.673211e-03 -5.000844e-03
## C10.1_T0 1.126625e-02 -2.702988e-03 -4.262000e-03 -3.390677e-03
## C10.2_T0 5.510784e-03 -5.424947e-03 -1.351346e-03 7.842518e-04
## C14.1_T0 6.152193e-03 -3.248544e-03 -2.703965e-03 -2.704157e-03
## C14.2_T0 4.652372e-03 -4.838569e-03 -4.201681e-03 -1.354434e-03
## C16.1_T0 3.683909e-03 -4.229939e-03 -6.482238e-04 -6.800247e-04
## C16.2_T0 3.241681e-03 -3.740274e-03 -1.902303e-03 1.702781e-03
## C16.2.OH_T0 3.404412e-03 -4.405002e-03 -3.422452e-04 1.331919e-03
## C18.1_T0 3.904052e-03 -3.596709e-03 -5.560590e-04 -8.375768e-04
## C18.1.OH_T0 2.579825e-03 -4.007293e-03 -2.116971e-03 2.134725e-03
## C18.2_T0 2.964809e-03 -4.032967e-03 -1.883821e-03 8.011779e-04
## lysoPC.a.C16.0_T0 -1.673356e-02 -1.616807e-02 4.123509e-02 -1.809499e-02
## lysoPC.a.C16.1_T0 -3.617442e-03 9.514075e-03 3.478218e-02 2.809260e-04
## lysoPC.a.C17.0_T0 -4.377135e-03 1.288832e-02 2.312110e-02 1.591319e-02
## lysoPC.a.C18.0_T0 -1.916548e-02 -3.043385e-02 1.686891e-02 -2.883884e-03
## lysoPC.a.C18.1_T0 -9.658178e-03 -2.545349e-02 1.731783e-02 3.710357e-02
## lysoPC.a.C18.2_T0 5.912615e-02 2.355479e-02 -2.207912e-02 -1.318941e-02
## lysoPC.a.C20.3_T0 -2.813953e-02 -1.165988e-03 5.696584e-03 7.203587e-02
## lysoPC.a.C20.4_T0 -7.264832e-02 -3.253345e-03 -1.322614e-02 2.015768e-02
## lysoPC.a.C24.0_T0 6.749710e-03 -9.396803e-03 -9.493631e-04 1.337295e-02
## lysoPC.a.C26.0_T0 1.330837e-02 1.654462e-02 -7.825633e-02 4.822388e-02
## lysoPC.a.C26.1_T0 5.118582e-04 -8.441365e-03 -5.300272e-03 2.819321e-03
## lysoPC.a.C28.0_T0 -4.921513e-02 -3.004106e-02 -3.624107e-02 -1.374686e-02
## lysoPC.a.C28.1_T0 1.521864e-03 -3.650571e-03 -3.724861e-03 8.993916e-05
## PC.aa.C24.0_T0 -2.095431e-02 -9.599628e-02 -1.923210e-02 9.883654e-02
## PC.aa.C28.1_T0 -5.116071e-03 1.828717e-02 9.267266e-03 -2.195270e-02
## PC.aa.C30.0_T0 4.457123e-03 -1.701496e-03 -1.074099e-02 6.322717e-02
## PC.aa.C32.0_T0 8.808951e-03 5.692976e-03 3.715144e-02 1.068255e-01
## PC.aa.C32.1_T0 -4.450511e-03 1.780353e-02 -4.592519e-03 6.559336e-02
## PC.aa.C32.3_T0 3.564139e-03 -5.098695e-03 -4.558131e-04 4.198439e-03
## PC.aa.C34.1_T0 2.077180e-02 -1.007178e-02 -6.108511e-03 5.295730e-02
## PC.aa.C34.2_T0 7.038722e-02 -3.856622e-02 -1.566067e-03 -7.569088e-02
## PC.aa.C34.3_T0 8.697313e-03 -2.014281e-02 6.402077e-04 1.894291e-02
## PC.aa.C34.4_T0 -1.930296e-03 -1.700429e-02 -1.320854e-02 1.492876e-02
## PC.aa.C36.0_T0 3.110768e-03 8.797397e-03 9.989321e-03 -1.900153e-03
## PC.aa.C36.1_T0 -1.360008e-02 -9.502390e-02 -2.087361e-02 4.512986e-02
## PC.aa.C36.2_T0 4.636597e-02 -5.537991e-02 -3.645223e-02 -6.798981e-02
## PC.aa.C36.3_T0 -1.054876e-02 -5.741649e-02 2.280933e-02 6.146668e-02
## PC.aa.C36.4_T0 -3.624542e-02 -4.498101e-02 1.381459e-02 -4.061575e-03
## PC.aa.C36.5_T0 -1.271675e-02 1.479180e-02 1.060578e-01 3.277473e-02
## PC.aa.C38.0_T0 -4.036328e-03 5.467402e-03 3.433405e-02 1.537171e-02
## PC.aa.C38.1_T0 1.818370e-02 -1.019066e-02 1.528518e-02 3.786139e-02
## PC.aa.C38.3_T0 -2.466672e-02 -7.706939e-02 2.240239e-02 6.406367e-02
## PC.aa.C38.4_T0 -4.542884e-02 -6.236637e-02 -9.990160e-03 4.876427e-02
## PC.aa.C38.5_T0 1.464493e-02 2.658236e-02 6.115717e-02 1.513682e-02
## PC.aa.C38.6_T0 5.330052e-02 -2.888469e-02 7.438040e-02 4.556080e-03
## PC.aa.C40.1_T0 -2.805738e-02 3.527967e-02 -1.107484e-02 7.158935e-03
## PC.aa.C40.2_T0 -4.001677e-03 -2.961530e-03 7.373033e-04 -6.647071e-03
## PC.aa.C40.3_T0 -2.019850e-03 -8.097840e-03 3.108839e-03 -2.188646e-04
## PC.aa.C40.4_T0 6.998579e-03 8.495565e-03 1.234807e-02 -1.003835e-02
## PC.aa.C40.5_T0 -1.574397e-03 -8.574212e-03 3.332484e-02 1.052817e-03
## PC.aa.C40.6_T0 4.782177e-02 -4.163116e-02 1.221194e-01 1.178603e-02
## PC.aa.C42.0_T0 -1.648758e-03 -6.355556e-04 4.406960e-03 5.572796e-04
## PC.aa.C42.1_T0 2.425545e-03 -2.545229e-03 2.861560e-03 -1.177896e-04
## PC.aa.C42.2_T0 -4.734955e-05 -4.581570e-03 3.214666e-03 -2.741161e-03
## PC.aa.C42.4_T0 5.912361e-04 -2.661616e-03 3.198605e-03 1.344763e-03
## PC.aa.C42.5_T0 1.826560e-03 -9.324847e-04 -4.932944e-04 3.496773e-03
## PC.aa.C42.6_T0 -2.573963e-02 -1.059639e-02 -4.372586e-02 1.009424e-02
## PC.ae.C30.0_T0 -7.516526e-04 1.005163e-03 2.125731e-03 2.826654e-03
## PC.ae.C32.1_T0 -1.320083e-02 2.311314e-02 2.182880e-02 8.941901e-03
## PC.ae.C32.2_T0 1.042918e-03 -7.199079e-04 9.037812e-03 3.553664e-03
## PC.ae.C34.0_T0 -2.761215e-03 9.281932e-03 9.207850e-03 7.293056e-03
## PC.ae.C34.1_T0 -1.908872e-02 1.262645e-02 2.650650e-02 3.797661e-02
## PC.ae.C34.2_T0 1.490784e-02 5.209626e-03 -1.289851e-02 6.819930e-02
## PC.ae.C34.3_T0 4.123700e-03 -5.634095e-03 -1.703281e-02 -3.473835e-03
## PC.ae.C36.0_T0 2.545226e-03 -2.430401e-03 2.456159e-03 9.474722e-03
## PC.ae.C36.1_T0 -7.216095e-03 5.117093e-03 1.343239e-02 -8.836671e-03
## PC.ae.C36.2_T0 6.509531e-03 1.472681e-02 3.103773e-02 -7.574557e-03
## PC.ae.C36.3_T0 1.400610e-02 -6.371572e-03 -2.112645e-02 5.781125e-02
## PC.ae.C36.4_T0 -3.697684e-02 4.457777e-02 -2.995989e-02 4.339813e-02
## PC.ae.C36.5_T0 -3.111349e-02 4.818214e-02 2.964846e-02 2.129001e-02
## PC.ae.C38.0_T0 -7.113458e-03 -6.666165e-03 2.340031e-03 -5.222475e-03
## PC.ae.C38.2_T0 -1.459864e-02 4.455962e-03 1.562617e-02 -2.569139e-02
## PC.ae.C38.3_T0 -1.741326e-02 -1.834660e-03 1.262245e-03 6.922950e-03
## PC.ae.C38.4_T0 -4.667427e-02 6.083967e-02 4.024411e-03 1.370905e-02
## PC.ae.C38.5_T0 -1.360820e-02 3.912812e-02 2.353043e-02 3.917278e-02
## PC.ae.C38.6_T0 -4.087954e-04 1.976888e-02 4.321303e-02 2.024006e-02
## PC.ae.C40.1_T0 -1.264570e-03 -1.582277e-02 1.374504e-03 -3.756980e-03
## PC.ae.C40.2_T0 -1.079117e-02 1.446540e-02 1.854808e-02 -7.534586e-03
## PC.ae.C40.3_T0 -1.404889e-02 -2.618539e-03 5.051882e-03 -6.241718e-03
## PC.ae.C40.4_T0 -2.150620e-02 2.034679e-02 1.014619e-02 -4.067720e-03
## PC.ae.C40.5_T0 -1.357528e-02 1.513235e-02 1.800984e-02 2.581932e-04
## PC.ae.C40.6_T0 2.207332e-03 2.205004e-02 3.504770e-02 2.628809e-03
## PC.ae.C42.1_T0 3.259163e-03 -5.338091e-03 2.137219e-03 -8.858046e-04
## PC.ae.C42.2_T0 -1.100979e-03 -1.683039e-03 3.220573e-03 -4.365996e-03
## PC.ae.C42.3_T0 1.571863e-03 -7.250826e-03 5.804319e-03 -7.847871e-03
## PC.ae.C42.4_T0 -7.725219e-03 3.086941e-03 -4.239043e-03 -1.220054e-02
## PC.ae.C42.5_T0 -2.459670e-02 1.616318e-02 1.015091e-02 -1.546741e-03
## PC.ae.C44.3_T0 3.259718e-03 -3.865322e-03 1.203264e-03 -2.241184e-04
## PC.ae.C44.4_T0 2.256718e-03 1.299221e-03 -7.543764e-03 7.931163e-04
## PC.ae.C44.5_T0 -9.713322e-03 2.323594e-02 8.407531e-03 -2.326736e-03
## PC.ae.C44.6_T0 -7.869549e-03 9.031787e-03 1.231966e-02 -9.287955e-03
## SM..OH..C14.1_T0 -1.206387e-02 7.637409e-02 1.163991e-02 2.433765e-03
## SM..OH..C16.1_T0 6.236148e-03 1.631472e-02 1.169190e-03 -9.418055e-03
## SM..OH..C22.1_T0 -5.815749e-02 -6.102989e-03 -3.462859e-02 1.257904e-02
## SM..OH..C22.2_T0 -4.652941e-02 1.615973e-02 1.833480e-02 -2.148089e-02
## SM..OH..C24.1_T0 -1.011439e-03 3.854518e-03 1.341700e-03 -2.393987e-03
## SM.C16.0_T0 4.993957e-03 -1.017161e-02 -6.236431e-02 2.848917e-02
## SM.C16.1_T0 4.356535e-02 -6.960150e-03 5.190569e-02 -8.568410e-02
## SM.C18.0_T0 2.421285e-02 2.358433e-02 -9.479895e-02 -3.676540e-02
## SM.C18.1_T0 4.302277e-02 -2.056956e-02 -1.407185e-02 -1.290026e-01
## SM.C20.2_T0 1.007658e-03 3.436142e-04 -2.588749e-03 6.749759e-03
## SM.C24.0_T0 -2.504011e-02 -7.498023e-02 -9.438140e-02 3.108451e-02
## SM.C24.1_T0 -2.294214e-02 -4.313525e-02 -5.539664e-02 6.013529e-02
## MEDDM_T2 2.668735e-03 -2.944163e-03 -1.501050e-03 2.207501e-03
## MEDCOL_T2 2.668735e-03 -2.944163e-03 -1.501050e-03 2.207501e-03
## MEDINF_T2 1.682208e-02 -1.752683e-02 -1.905706e-02 1.547918e-02
## MEDHTA_T2 -6.891035e-03 2.260814e-02 -1.328919e-02 1.275571e-02
## GLU_T2 -4.570527e-02 1.939231e-02 6.362681e-02 1.018006e-02
## INS_T2 -4.114747e-02 -1.854683e-02 5.941759e-02 -6.121257e-02
## HOMA_T2 -3.993229e-02 -9.893382e-03 3.327398e-02 -2.315196e-02
## HBA1C_T2 -2.471319e-03 6.779299e-04 1.164125e-02 5.141815e-04
## HBA1C.mmol.mol_T2 4.000010e-03 1.279270e-02 5.006008e-02 -7.781708e-03
## PESO_T2 2.404442e-02 -1.583119e-02 3.707688e-02 2.486513e-02
## bmi_T2 1.410854e-02 2.741201e-03 9.872995e-02 4.291013e-02
## CC_T2 -9.307507e-03 -5.776549e-03 -6.081675e-03 -2.930638e-03
## CINT_T2 -9.710244e-02 -3.105932e-02 -2.471876e-02 6.089865e-03
## CAD_T2 -3.356667e-03 -2.607943e-02 1.397538e-02 6.476737e-02
## TAD_T2 6.559047e-03 1.805183e-02 6.788121e-02 7.050888e-02
## TAS_T2 7.514144e-02 2.972199e-02 -1.140894e-02 -5.231541e-03
## TG_T2 1.197355e-01 -1.500382e-03 1.021529e-01 -5.224456e-02
## COL_T2 5.996964e-02 -2.992649e-03 8.717807e-02 -1.805720e-02
## LDL_T2 2.401611e-02 -2.843633e-02 8.650587e-02 3.514583e-05
## HDL_T2 7.821812e-02 5.452385e-02 2.597321e-03 -2.426120e-02
## VLDL_T2 1.984380e-02 7.046217e-03 1.563992e-02 -2.658621e-02
## PCR_T2 2.894130e-02 -4.987453e-02 7.954493e-02 -2.653188e-02
## LEP_T2 1.935651e-02 3.951189e-02 7.296870e-03 -4.614283e-02
## ADIPO_T2 3.652449e-02 -9.358185e-03 -2.867175e-02 1.488694e-02
## GOT_T2 -2.940659e-02 7.218945e-03 1.770379e-02 -1.440264e-01
## GPT_T2 -8.044468e-02 3.173460e-02 2.396456e-02 -2.629069e-01
## GGT_T2 7.253275e-02 3.013837e-02 -1.820677e-02 -1.438159e-01
## URICO_T2 -3.211473e-02 -7.391663e-02 -5.578677e-02 -1.619452e-02
## CREAT_T2 2.159655e-03 1.985047e-03 -1.428237e-03 4.911879e-03
## UREA_T2 -1.331356e-01 3.911130e-02 -5.505046e-02 6.943138e-02
## HIERRO_T2 6.728362e-02 -5.426084e-02 3.129780e-02 1.183156e-01
## TRANSF_T2 -4.766121e-02 -1.633539e-02 -2.392136e-02 -4.135679e-02
## FERR_T2 -7.802336e-02 -2.919080e-03 1.187694e-02 2.260922e-03
## Ile_T2 -6.723977e-02 5.678461e-04 -2.419299e-02 1.993041e-02
## Leu_T2 -2.905746e-02 -3.984059e-03 6.115906e-03 2.451041e-02
## Val_T2 -3.317300e-02 1.487754e-02 -1.386384e-02 5.948030e-02
## Ala_T2 -1.749177e-02 7.588916e-02 8.209562e-02 5.865264e-02
## Pro_T2 1.182098e-02 7.541496e-02 -3.794199e-03 1.085118e-04
## Gly_T2 -1.182576e-01 -2.679758e-02 -1.033795e-01 -6.701407e-02
## Ser_T2 -4.900838e-02 4.075130e-02 3.369053e-03 1.765945e-02
## Trp_T2 -7.439418e-02 -1.313949e-03 -3.368107e-02 -4.803597e-02
## Phe_T2 1.375372e-02 1.994784e-03 3.756296e-02 -1.614427e-02
## Met_T2 -5.326031e-02 1.634469e-02 2.782972e-02 -1.848627e-02
## Orn_T2 -8.158957e-03 -1.326520e-02 4.939474e-02 3.324077e-02
## Arg_T2 8.736968e-02 1.223705e-02 5.102004e-03 8.779946e-02
## His_T2 -2.098698e-02 -3.059346e-02 6.529279e-02 7.795623e-02
## Asn_T2 -1.072629e-02 -4.720545e-02 2.775904e-02 2.054086e-02
## Asp_T2 4.322092e-02 -8.501933e-03 -3.906025e-03 5.107535e-03
## Glu_T2 3.798142e-02 7.490913e-03 -1.513502e-02 -2.848395e-02
## Gln_T2 -4.362387e-02 4.088093e-02 -6.188496e-02 7.151829e-02
## Cit_T2 -1.055374e-02 -3.721640e-02 8.982772e-02 -1.515561e-02
## Tyr_T2 -7.088334e-02 -7.024086e-02 8.068050e-02 1.909948e-02
## Thr_T2 1.986340e-03 -8.906686e-02 1.050705e-02 -9.928479e-02
## Lys_T2 -2.097926e-02 -2.735394e-02 1.100230e-01 1.350894e-02
## Creatinine_T2 6.483049e-03 -2.288386e-03 2.469796e-02 1.327157e-04
## Kynurenine_T2 -1.160758e-02 -1.388568e-03 2.169626e-02 -3.947494e-02
## Putrescine_T2 -8.836621e-02 3.284911e-02 -6.474941e-03 -1.205042e-01
## Sarcosine_T2 -2.972583e-02 5.141956e-02 1.541067e-02 -1.284317e-01
## Serotonin_T2 3.305737e-02 1.308341e-02 -6.516640e-03 3.350923e-02
## Taurine_T2 -1.036320e-01 -1.281883e-03 9.857142e-02 -9.249422e-02
## SDMA_T2 1.053032e-02 1.745527e-03 1.059940e-02 -2.096192e-02
## C0_T2 -2.321632e-02 -1.832956e-02 3.270503e-02 5.603542e-02
## C2_T2 6.188228e-02 -8.556484e-02 -7.624467e-02 7.838213e-02
## C3.OH_T2 -6.664685e-04 -2.402473e-03 -3.353376e-03 5.242346e-03
## C6..C4.1.DC._T2 -5.231586e-02 5.845508e-02 -2.896243e-02 -1.284240e-02
## C5.DC..C6.OH._T2 -3.269099e-02 3.322787e-02 -4.081070e-02 -8.453599e-02
## C7.DC_T2 8.816849e-02 1.071233e-01 3.209841e-02 7.288646e-02
## C8_T2 3.041680e-03 3.679926e-03 1.411638e-03 7.003910e-03
## C10_T2 8.945860e-03 4.788566e-03 1.045411e-02 4.848948e-03
## C10.1_T2 8.642744e-03 2.873013e-05 2.053809e-03 3.329449e-03
## C10.2_T2 6.713043e-04 -1.467397e-03 8.938108e-04 3.070415e-03
## C14.1_T2 5.809916e-03 -3.498766e-03 -7.055632e-04 3.970351e-03
## C14.2_T2 3.558564e-03 -1.937667e-03 -1.378428e-03 3.740500e-03
## C16.1_T2 3.265353e-03 -2.719691e-03 -1.348313e-03 3.051986e-03
## C16.2_T2 2.587774e-03 -2.507386e-03 -1.249875e-03 2.733849e-03
## C16.2.OH_T2 2.079065e-03 -2.238689e-03 -1.578909e-03 2.644854e-03
## C18.1_T2 4.683054e-03 -5.545155e-03 -3.635516e-03 4.841087e-04
## C18.1.OH_T2 3.285175e-03 -2.760585e-03 -1.727340e-03 2.754006e-03
## C18.2_T2 4.335498e-03 -2.678537e-03 -5.153155e-03 2.314459e-03
## lysoPC.a.C14.0_T2 -9.458924e-03 -1.130885e-02 1.061336e-02 -1.509022e-02
## lysoPC.a.C16.0_T2 7.218195e-02 2.165287e-03 -4.093626e-02 -3.953906e-03
## lysoPC.a.C16.1_T2 8.665180e-03 -1.265518e-02 1.532068e-02 -1.175359e-02
## lysoPC.a.C17.0_T2 1.569421e-02 8.351613e-04 -8.631425e-03 1.758355e-03
## lysoPC.a.C18.0_T2 5.312906e-02 -1.565574e-02 -3.739553e-03 -5.346418e-02
## lysoPC.a.C18.1_T2 6.040689e-02 -8.298299e-03 1.448888e-02 -1.969357e-03
## lysoPC.a.C18.2_T2 1.295025e-01 8.255837e-02 -8.694193e-02 5.661706e-02
## lysoPC.a.C20.3_T2 1.035077e-02 -1.245017e-02 2.547000e-02 -6.414805e-04
## lysoPC.a.C20.4_T2 4.921307e-02 1.551366e-02 -5.555328e-02 -2.080461e-02
## lysoPC.a.C24.0_T2 1.538288e-03 -4.794982e-03 -3.560304e-03 6.409333e-03
## lysoPC.a.C26.0_T2 -5.021060e-02 -1.514955e-01 -9.414812e-03 1.168179e-01
## lysoPC.a.C26.1_T2 -6.272059e-03 -7.441298e-03 -6.215195e-03 4.297928e-03
## lysoPC.a.C28.0_T2 -7.007297e-02 -4.080513e-03 1.361308e-02 -2.071638e-02
## lysoPC.a.C28.1_T2 1.531585e-03 -9.513638e-03 -1.765673e-03 5.117582e-03
## PC.aa.C24.0_T2 3.594537e-03 -7.208285e-02 -4.243514e-02 -3.313250e-02
## PC.aa.C28.1_T2 6.189109e-05 3.009233e-02 -1.484193e-02 2.557936e-02
## PC.aa.C30.0_T2 -1.513970e-03 7.526320e-03 -4.720736e-03 2.101249e-02
## PC.aa.C32.0_T2 -1.068860e-02 -7.050237e-03 -5.254563e-02 8.734308e-02
## PC.aa.C32.1_T2 -3.395525e-02 -2.174594e-02 4.532836e-02 4.167086e-02
## PC.aa.C32.3_T2 4.888051e-03 -2.329118e-03 -9.813251e-04 6.136585e-04
## PC.aa.C34.1_T2 -6.980173e-04 -5.497794e-02 3.682742e-02 5.548531e-02
## PC.aa.C34.2_T2 1.100421e-01 -3.512901e-02 -7.555538e-02 3.715253e-02
## PC.aa.C34.3_T2 2.778522e-02 -1.692193e-02 2.464009e-02 1.013502e-02
## PC.aa.C34.4_T2 1.738189e-03 -1.570687e-03 1.226521e-03 1.279445e-03
## PC.aa.C36.0_T2 2.254494e-02 8.258316e-03 -3.178536e-03 1.419171e-02
## PC.aa.C36.1_T2 -3.678256e-02 -4.506899e-02 5.278968e-02 -2.547887e-02
## PC.aa.C36.2_T2 5.026118e-02 1.020173e-02 3.427028e-02 -2.636189e-02
## PC.aa.C36.3_T2 -2.184962e-03 -6.691745e-02 5.601544e-02 -3.032912e-02
## PC.aa.C36.4_T2 1.972463e-02 -4.564738e-02 1.863566e-02 -7.138577e-02
## PC.aa.C36.5_T2 5.077912e-02 2.145242e-02 -3.306522e-02 5.454270e-02
## PC.aa.C38.0_T2 -1.448840e-02 -1.757968e-03 -3.768180e-03 6.642462e-04
## PC.aa.C38.1_T2 2.974122e-02 1.763903e-02 -1.426676e-02 2.162158e-02
## PC.aa.C38.3_T2 -1.051315e-02 -3.948858e-02 6.852043e-02 -3.115052e-02
## PC.aa.C38.4_T2 1.107232e-02 -7.356897e-02 6.899774e-02 -9.736762e-02
## PC.aa.C38.5_T2 4.117568e-02 -5.428246e-02 2.391607e-02 -1.109075e-02
## PC.aa.C38.6_T2 5.960159e-02 -4.094345e-02 -6.559571e-02 -1.124812e-02
## PC.aa.C40.1_T2 4.346464e-02 -1.635888e-01 -4.360089e-02 -6.425776e-02
## PC.aa.C40.2_T2 1.358794e-02 -1.034088e-02 -2.064639e-03 1.103148e-02
## PC.aa.C40.3_T2 1.389258e-02 -6.506192e-03 -3.352760e-04 7.699377e-03
## PC.aa.C40.4_T2 1.725314e-03 -1.601053e-02 2.387371e-02 -1.719349e-03
## PC.aa.C40.5_T2 4.587904e-03 -3.588345e-02 6.043888e-02 -1.617522e-02
## PC.aa.C40.6_T2 2.548853e-02 -8.371938e-03 -4.098232e-02 -3.424131e-02
## PC.aa.C42.0_T2 -1.454964e-03 8.294015e-04 -5.954905e-03 5.028339e-03
## PC.aa.C42.1_T2 5.334015e-03 -1.215300e-03 -3.481761e-03 3.508012e-03
## PC.aa.C42.2_T2 6.257972e-03 -2.051431e-03 -1.574913e-03 7.416852e-03
## PC.aa.C42.4_T2 2.500655e-03 -4.452092e-03 -2.174821e-03 5.933997e-03
## PC.aa.C42.5_T2 4.241132e-03 -2.740264e-03 -2.590981e-03 4.780854e-03
## PC.aa.C42.6_T2 -7.304794e-02 1.918219e-05 -1.188027e-01 -3.383129e-02
## PC.ae.C30.0_T2 -9.740284e-02 8.252149e-02 3.422521e-02 -2.848148e-02
## PC.ae.C32.1_T2 -2.404023e-02 6.029461e-03 6.094501e-03 1.003936e-02
## PC.ae.C32.2_T2 1.610532e-03 -4.838884e-03 -3.061818e-03 2.127775e-03
## PC.ae.C34.0_T2 4.029970e-03 4.655621e-03 -2.513155e-03 4.785351e-03
## PC.ae.C34.1_T2 -4.482871e-02 -3.548230e-02 1.976570e-02 -6.724454e-03
## PC.ae.C34.2_T2 -2.117748e-02 -8.920882e-03 1.179441e-02 1.810135e-02
## PC.ae.C34.3_T2 2.375628e-03 5.755991e-03 -2.324995e-02 2.912792e-02
## PC.ae.C36.0_T2 3.487075e-03 -2.956396e-03 -2.506002e-03 1.513722e-02
## PC.ae.C36.1_T2 3.348839e-02 -1.327340e-02 2.297312e-03 2.996057e-02
## PC.ae.C36.2_T2 2.624234e-02 -1.055291e-02 1.745879e-02 -5.823491e-03
## PC.ae.C36.3_T2 -1.708139e-02 -1.602396e-02 -1.558933e-05 -3.178289e-04
## PC.ae.C36.4_T2 -3.592283e-02 5.937461e-03 2.139499e-02 5.784454e-03
## PC.ae.C36.5_T2 -2.231031e-02 1.094410e-03 1.532238e-02 1.220323e-03
## PC.ae.C38.0_T2 1.328339e-02 1.437817e-05 -3.256741e-03 1.079965e-03
## PC.ae.C38.2_T2 2.259013e-02 -1.348594e-02 -1.007522e-02 2.546297e-02
## PC.ae.C38.3_T2 1.430428e-02 -8.371109e-03 3.218888e-03 1.702377e-02
## PC.ae.C38.4_T2 -2.768821e-02 -4.241398e-03 2.685023e-02 -2.948562e-02
## PC.ae.C38.5_T2 -3.650464e-02 2.342516e-02 3.485456e-02 -3.768278e-02
## PC.ae.C38.6_T2 -2.546659e-03 -6.259347e-03 1.131070e-02 -8.534075e-03
## PC.ae.C40.1_T2 2.185674e-02 -6.718110e-03 -3.477198e-03 1.011883e-02
## PC.ae.C40.2_T2 4.276365e-04 5.837607e-03 -1.131886e-02 7.904521e-03
## PC.ae.C40.3_T2 9.430491e-03 -5.625749e-03 -7.128866e-03 1.496590e-02
## PC.ae.C40.4_T2 -3.460634e-03 2.168179e-03 2.222651e-03 5.496605e-04
## PC.ae.C40.5_T2 -1.955950e-02 5.664610e-03 8.645316e-03 -6.229016e-03
## PC.ae.C40.6_T2 -3.493355e-03 -6.485535e-04 -1.187230e-04 -1.379061e-02
## PC.ae.C42.1_T2 1.194923e-02 -7.877520e-03 -2.398041e-03 6.455953e-03
## PC.ae.C42.2_T2 9.192776e-03 -6.136224e-03 -2.886363e-03 7.420195e-03
## PC.ae.C42.3_T2 1.377387e-02 -3.708712e-03 -1.288525e-02 6.272293e-03
## PC.ae.C42.4_T2 -3.276609e-03 4.332534e-03 4.157020e-04 6.021572e-03
## PC.ae.C42.5_T2 -3.636636e-02 8.645520e-03 -6.959770e-03 -2.184907e-02
## PC.ae.C44.3_T2 2.227203e-02 -1.968462e-02 2.165980e-02 3.289356e-02
## PC.ae.C44.4_T2 -3.581303e-03 -1.829357e-03 -6.962391e-03 5.974860e-03
## PC.ae.C44.5_T2 -2.269063e-02 1.094323e-02 -1.543354e-02 -9.053648e-03
## PC.ae.C44.6_T2 -1.017566e-02 1.159292e-02 -1.668212e-02 -6.555222e-03
## SM..OH..C14.1_T2 -1.421702e-02 2.989212e-02 4.427754e-05 2.544525e-02
## SM..OH..C16.1_T2 -9.128909e-03 1.003855e-02 -5.007513e-03 2.623212e-03
## SM..OH..C22.1_T2 -2.030412e-02 -1.314206e-03 -1.926612e-03 -4.301213e-03
## SM..OH..C22.2_T2 -3.112154e-02 -1.890028e-03 4.825164e-03 -1.718870e-02
## SM..OH..C24.1_T2 -2.298941e-03 2.052607e-04 -4.082351e-03 6.138651e-04
## SM.C16.0_T2 -2.985974e-02 6.203384e-02 -2.749436e-02 9.977794e-02
## SM.C16.1_T2 4.458047e-02 3.163078e-02 1.069164e-02 1.329155e-02
## SM.C18.0_T2 -1.330546e-02 2.240846e-02 -2.750105e-02 1.409582e-02
## SM.C18.1_T2 1.160084e-02 3.669603e-03 -3.171694e-02 -4.786518e-02
## SM.C20.2_T2 6.014312e-04 -2.202504e-03 -2.367688e-03 2.055381e-03
## SM.C24.0_T2 -1.526035e-02 1.387457e-02 -3.239311e-02 7.545180e-02
## SM.C24.1_T2 -4.475323e-02 3.925708e-02 -8.052957e-02 5.086350e-02
## MEDDM_T4 -1.600437e-03 -3.158207e-03 -2.321748e-03 2.924357e-03
## MEDCOL_T4 4.538998e-03 -8.824277e-05 7.085685e-03 6.316160e-03
## MEDINF_T4 1.304325e-02 1.725163e-02 -9.676649e-03 -7.921124e-03
## MEDHTA_T4 6.521952e-03 2.314149e-02 -7.898426e-03 1.386024e-02
## GLU_T4 -4.921426e-02 -7.009814e-03 3.983574e-03 3.429229e-03
## INS_T4 -1.653541e-01 -8.850885e-02 -2.823406e-02 -3.477197e-02
## HOMA_T4 -5.944794e-02 -3.199971e-02 -1.359061e-02 -6.687560e-03
## HBA1C_T4 -9.272345e-04 1.093657e-02 7.055293e-03 -1.238532e-02
## HBA1C.mmol.mol_T4 8.932764e-03 4.617307e-02 2.815475e-02 -5.076108e-02
## PESO_T4 3.940905e-02 -3.097104e-02 3.833462e-02 2.721196e-02
## bmi_T4 3.421309e-02 -1.309618e-02 1.130565e-01 4.670757e-02
## CC_T4 -3.721446e-03 -7.700943e-03 -7.355845e-04 -1.302431e-03
## CINT_T4 -6.347752e-02 -5.182826e-02 1.685824e-02 2.106046e-02
## CAD_T4 -1.405526e-02 1.063380e-02 3.185726e-03 6.459644e-02
## TAD_T4 -4.571172e-02 8.372618e-02 -4.920902e-02 1.299523e-01
## TAS_T4 7.224245e-02 2.965270e-02 -5.427674e-02 2.231433e-02
## TG_T4 -2.082365e-02 1.695977e-02 2.381051e-03 -4.968155e-03
## COL_T4 -2.073306e-02 7.865127e-03 7.248325e-02 7.836895e-03
## LDL_T4 -3.133055e-02 -2.519409e-02 8.297498e-02 3.932640e-02
## HDL_T4 9.259855e-03 4.356182e-02 2.648833e-02 -3.599558e-02
## VLDL_T4 -9.434502e-02 8.641345e-03 -9.747899e-03 -5.398595e-02
## PCR_T4 -1.691426e-03 -1.379296e-01 -6.854486e-02 -2.458949e-02
## LEP_T4 7.560696e-02 8.752211e-02 -1.052157e-01 -9.788118e-02
## ADIPO_T4 -7.297401e-02 -1.038839e-02 2.056991e-02 -2.176299e-02
## GOT_T4 -6.027211e-02 -1.043736e-01 -2.307141e-02 -1.019590e-03
## GPT_T4 -2.774868e-02 -3.393208e-02 1.885792e-02 5.889415e-02
## GGT_T4 7.002903e-02 1.325877e-01 -2.030739e-01 -1.645317e-02
## URICO_T4 -3.458830e-02 -7.918033e-02 -1.039450e-01 -1.281032e-03
## CREAT_T4 5.311662e-03 -1.030198e-02 1.659291e-03 5.049302e-03
## UREA_T4 -8.653620e-03 3.858921e-02 -2.657385e-03 2.126116e-02
## HIERRO_T4 -4.965722e-02 7.879370e-03 -8.505779e-03 -1.827753e-02
## TRANSF_T4 -5.636245e-02 -1.920323e-02 -7.010401e-02 1.550246e-02
## FERR_T4 -2.452751e-02 -9.256441e-02 -4.505062e-02 -2.896964e-03
## Ile_T4 -4.660678e-02 -7.611785e-02 3.528492e-02 2.608775e-02
## Leu_T4 1.728129e-02 -2.595442e-02 -8.716304e-03 2.710942e-02
## Val_T4 2.081774e-03 -4.813208e-02 1.922149e-02 -3.306431e-02
## Ala_T4 1.336653e-02 -1.563246e-02 7.113935e-02 6.855911e-02
## Pro_T4 -2.883450e-02 5.674346e-02 1.163350e-01 4.025340e-02
## Gly_T4 -4.246759e-02 3.790522e-03 -2.436069e-02 -8.773170e-04
## Ser_T4 -2.050485e-02 7.388130e-02 2.273140e-03 7.100258e-02
## Trp_T4 -1.217771e-02 -3.496348e-02 -2.875801e-02 -3.005239e-02
## Phe_T4 8.821827e-02 2.585917e-02 2.646442e-02 1.132177e-02
## Met_T4 4.182166e-02 1.077954e-02 3.026729e-02 1.059442e-03
## Orn_T4 1.541962e-02 -9.791146e-02 3.290255e-02 -2.182921e-02
## Arg_T4 4.643117e-02 -1.492571e-02 -2.050039e-02 3.981656e-02
## His_T4 5.992484e-02 -2.708031e-02 3.810857e-02 2.590189e-02
## Asn_T4 2.002470e-02 -1.800838e-02 -1.386367e-02 2.908530e-02
## Asp_T4 -2.795292e-02 -1.095431e-02 -1.021671e-01 -1.556914e-02
## Glu_T4 -1.497819e-02 1.920032e-02 -5.649953e-02 -3.672160e-02
## Gln_T4 -1.689278e-02 -5.345542e-03 -7.481553e-03 6.657152e-02
## Cit_T4 -7.964156e-02 -1.350393e-02 1.976192e-02 -3.560009e-02
## Tyr_T4 1.675295e-02 -4.361453e-02 5.339191e-02 2.466228e-02
## Thr_T4 -1.334614e-02 -5.372407e-02 -6.227500e-02 -1.060384e-02
## Lys_T4 5.606753e-02 2.157416e-02 1.356110e-02 4.606691e-02
## Creatinine_T4 -5.761267e-02 -2.360550e-03 -5.624324e-02 3.887449e-02
## Kynurenine_T4 4.094237e-02 4.295720e-02 -1.239762e-02 -8.232242e-03
## Putrescine_T4 2.383727e-02 2.077736e-03 4.817670e-02 -5.236184e-02
## Sarcosine_T4 -1.150725e-01 -6.156430e-02 2.535994e-01 5.992698e-02
## Serotonin_T4 3.181369e-03 1.742548e-02 1.326357e-04 4.451938e-02
## Taurine_T4 -8.974711e-02 -4.732461e-03 2.850454e-02 -9.378159e-03
## SDMA_T4 -3.925797e-03 6.177070e-03 -7.340829e-03 -3.259422e-03
## C0_T4 -1.231772e-02 -6.061596e-02 -1.118966e-02 -2.491219e-02
## C2_T4 2.595938e-02 -2.391441e-02 1.205669e-03 1.426413e-02
## C3.OH_T4 9.582040e-03 -3.401693e-03 1.071001e-03 -1.520822e-03
## C6..C4.1.DC._T4 1.830586e-02 2.037618e-01 4.681771e-02 -1.026149e-02
## C5.DC..C6.OH._T4 2.024774e-02 1.553347e-01 9.957889e-02 -7.405435e-02
## C7.DC_T4 -3.386637e-02 1.226856e-01 8.701971e-02 -1.106104e-01
## C8_T4 1.453438e-02 3.774238e-03 -1.528850e-03 -6.736945e-04
## C10_T4 1.058426e-02 3.495542e-03 -2.761809e-03 4.558758e-03
## C10.1_T4 5.612448e-03 -2.849661e-03 -2.143731e-03 1.053605e-03
## C10.2_T4 4.823004e-03 -1.158187e-03 7.928496e-04 1.808280e-03
## C14.1_T4 7.282751e-03 6.428245e-05 -3.148795e-03 2.257086e-03
## C14.2_T4 5.858694e-03 -2.182051e-03 -1.375058e-03 1.959070e-03
## C16.1_T4 5.686312e-02 3.149301e-02 6.133650e-02 -6.454650e-02
## C16.2_T4 4.280604e-03 -1.995368e-03 -1.939728e-03 2.675367e-03
## C16.2.OH_T4 5.535980e-02 2.988960e-02 6.108436e-02 -6.390740e-02
## C18.1_T4 4.053500e-03 -3.186287e-03 -3.357790e-03 2.129129e-03
## C18.1.OH_T4 3.695947e-03 -2.592175e-03 -1.895648e-03 2.310735e-03
## C18.2_T4 4.959015e-03 -2.977276e-03 -2.590920e-03 2.132109e-03
## lysoPC.a.C16.0_T4 7.502465e-02 -6.204233e-02 -4.329579e-02 -4.919559e-03
## lysoPC.a.C16.1_T4 4.437699e-02 -5.011678e-03 1.451368e-03 -4.538676e-03
## lysoPC.a.C17.0_T4 1.118164e-02 -1.973645e-02 9.496177e-03 -1.011922e-02
## lysoPC.a.C18.0_T4 3.779568e-02 -7.261444e-02 -5.871279e-02 -6.303536e-02
## lysoPC.a.C18.1_T4 3.122253e-02 -2.516714e-02 -3.429777e-02 -1.428407e-02
## lysoPC.a.C18.2_T4 1.781910e-02 -8.091116e-02 -5.379508e-02 1.036648e-02
## lysoPC.a.C20.3_T4 -1.303882e-02 -5.734536e-03 -2.026632e-02 3.164008e-02
## lysoPC.a.C20.4_T4 2.742801e-03 -9.958965e-03 2.126689e-03 1.997688e-02
## lysoPC.a.C24.0_T4 7.560841e-03 2.392890e-03 -1.270847e-03 3.626729e-04
## lysoPC.a.C26.0_T4 1.992055e-01 3.456238e-02 7.285507e-02 1.921736e-02
## lysoPC.a.C26.1_T4 1.092370e-02 -3.746980e-03 3.168661e-03 2.079154e-03
## lysoPC.a.C28.0_T4 4.415653e-02 -6.398170e-02 1.603632e-03 -9.852624e-02
## lysoPC.a.C28.1_T4 5.286393e-03 4.026612e-03 5.655780e-03 1.755369e-03
## PC.aa.C24.0_T4 1.207526e-01 -1.420696e-02 8.412247e-02 -1.962857e-03
## PC.aa.C28.1_T4 1.195921e-02 6.389590e-02 2.606601e-02 -1.197902e-02
## PC.aa.C30.0_T4 -3.694027e-03 2.019425e-02 2.318341e-02 2.476682e-02
## PC.aa.C32.0_T4 -4.911552e-02 4.540645e-02 1.283022e-02 2.795536e-02
## PC.aa.C32.1_T4 -3.627541e-02 4.697518e-02 -4.722837e-03 3.265280e-02
## PC.aa.C32.3_T4 1.162725e-03 -2.192692e-03 2.476939e-03 2.792404e-03
## PC.aa.C34.1_T4 -2.640936e-02 2.694426e-02 -1.994352e-03 -1.158220e-02
## PC.aa.C34.2_T4 -2.641827e-02 -4.571572e-02 -4.806278e-02 -1.135300e-02
## PC.aa.C34.3_T4 -4.979614e-03 -2.138475e-02 -5.015518e-04 7.467100e-03
## PC.aa.C34.4_T4 1.122445e-03 -1.440784e-03 9.446882e-03 2.604950e-03
## PC.aa.C36.0_T4 -4.321704e-03 -4.305370e-03 -1.419287e-02 4.682787e-03
## PC.aa.C36.1_T4 -5.112616e-02 8.776787e-02 1.012895e-02 -5.537358e-02
## PC.aa.C36.2_T4 -2.358626e-02 1.508495e-02 -6.323706e-03 -6.835054e-02
## PC.aa.C36.3_T4 -7.417754e-03 -3.268962e-03 2.450814e-04 1.075855e-02
## PC.aa.C36.4_T4 -3.096113e-02 2.882766e-03 5.806553e-02 1.543227e-02
## PC.aa.C36.5_T4 -1.330065e-02 -5.046270e-02 1.855757e-03 -1.599423e-02
## PC.aa.C38.0_T4 -4.430949e-04 8.811225e-03 -1.072204e-02 -8.763049e-03
## PC.aa.C38.1_T4 -2.578856e-02 -1.412691e-02 -5.474060e-03 -7.602649e-03
## PC.aa.C38.3_T4 -2.179157e-02 5.213778e-02 1.320121e-02 4.569272e-02
## PC.aa.C38.4_T4 -3.846277e-02 -8.198260e-03 6.240436e-02 -5.921354e-03
## PC.aa.C38.5_T4 -5.128103e-05 3.912776e-03 4.801522e-03 -3.728800e-03
## PC.aa.C38.6_T4 -2.312289e-02 -4.431893e-02 -2.211529e-02 -1.257685e-02
## PC.aa.C40.1_T4 9.675964e-02 -3.347610e-02 -1.400629e-01 -3.304715e-02
## PC.aa.C40.2_T4 -6.505588e-03 1.179774e-03 -8.830938e-04 4.894653e-03
## PC.aa.C40.3_T4 -1.719179e-03 3.191162e-03 -5.341906e-03 5.798385e-03
## PC.aa.C40.4_T4 1.212428e-02 2.946254e-02 1.180934e-02 -7.817479e-03
## PC.aa.C40.5_T4 6.812390e-03 1.148469e-02 2.119952e-02 -8.921470e-03
## PC.aa.C40.6_T4 -2.073451e-02 -2.662811e-02 -2.243670e-02 -4.003033e-02
## PC.aa.C42.0_T4 -2.958893e-03 9.734709e-04 -1.923715e-03 2.917940e-03
## PC.aa.C42.1_T4 1.295215e-03 1.874134e-03 -2.057167e-03 3.700820e-03
## PC.aa.C42.2_T4 -2.543814e-03 1.262108e-03 -8.276287e-04 2.550343e-04
## PC.aa.C42.4_T4 -1.072016e-03 -2.624526e-04 -6.441553e-04 1.291471e-03
## PC.aa.C42.5_T4 1.333048e-03 1.722367e-03 -1.243373e-03 6.600405e-05
## PC.aa.C42.6_T4 5.033167e-02 9.500686e-02 9.943712e-03 6.760756e-02
## PC.ae.C30.0_T4 2.784298e-02 5.815573e-02 -2.685886e-02 5.135484e-02
## PC.ae.C32.1_T4 -8.855390e-03 9.778502e-03 1.901080e-02 1.756055e-03
## PC.ae.C32.2_T4 -4.356185e-04 1.554569e-03 -9.964229e-04 -1.237623e-03
## PC.ae.C34.0_T4 -6.317192e-04 1.811205e-03 5.312508e-03 3.348434e-03
## PC.ae.C34.1_T4 -3.899317e-02 4.569744e-02 2.897851e-02 4.488242e-03
## PC.ae.C34.2_T4 6.664254e-03 2.366688e-02 1.170599e-03 -8.812769e-03
## PC.ae.C34.3_T4 -2.194117e-03 -5.202386e-03 -7.719254e-03 1.673487e-03
## PC.ae.C36.0_T4 -1.955793e-03 1.265743e-03 -4.554129e-03 -1.287918e-03
## PC.ae.C36.1_T4 -4.040160e-02 4.728696e-02 3.380432e-02 -8.469958e-03
## PC.ae.C36.2_T4 -1.984019e-02 1.489487e-03 2.257515e-02 -3.421286e-03
## PC.ae.C36.3_T4 1.068129e-02 6.443674e-03 -6.846794e-03 4.517690e-03
## PC.ae.C36.4_T4 3.396106e-02 2.570873e-02 3.098083e-03 4.139593e-03
## PC.ae.C36.5_T4 -1.622579e-02 3.449021e-02 -1.594009e-04 -2.268382e-02
## PC.ae.C38.0_T4 1.527796e-03 -8.499455e-03 -1.212830e-02 -9.051796e-03
## PC.ae.C38.2_T4 -2.545966e-02 2.993224e-03 6.759060e-03 -5.728060e-03
## PC.ae.C38.3_T4 -3.429049e-02 1.191930e-02 -1.837537e-05 1.544827e-02
## PC.ae.C38.4_T4 -3.490734e-02 4.936183e-02 4.032015e-02 2.505535e-03
## PC.ae.C38.5_T4 3.236537e-02 5.261082e-02 1.737374e-02 -1.426752e-02
## PC.ae.C38.6_T4 2.525562e-02 1.857283e-02 7.286349e-03 -1.819709e-02
## PC.ae.C40.1_T4 -4.775381e-04 -1.233492e-02 -5.699716e-05 -3.158003e-03
## PC.ae.C40.2_T4 -2.010606e-02 2.730191e-02 8.078435e-03 8.841762e-03
## PC.ae.C40.3_T4 -3.021891e-02 4.574039e-03 8.497268e-04 9.897639e-03
## PC.ae.C40.4_T4 -3.197644e-02 2.905206e-02 6.131070e-03 -1.812997e-03
## PC.ae.C40.5_T4 -2.361723e-02 2.910520e-02 9.090541e-03 2.060350e-03
## PC.ae.C40.6_T4 -2.975601e-03 7.641773e-03 5.428278e-03 -4.556518e-03
## PC.ae.C42.1_T4 -4.843676e-04 -3.522996e-03 -1.368652e-03 3.549177e-03
## PC.ae.C42.2_T4 1.364168e-03 -7.114321e-03 -3.093848e-03 5.772239e-03
## PC.ae.C42.3_T4 -1.328188e-03 -2.513758e-03 -2.049090e-03 -9.002504e-05
## PC.ae.C42.4_T4 -3.565436e-04 6.984332e-03 1.556011e-03 -1.995792e-03
## PC.ae.C42.5_T4 -1.583578e-02 1.981641e-02 1.426394e-02 6.132171e-04
## PC.ae.C44.3_T4 -2.931660e-05 2.140661e-04 -7.642360e-04 1.098241e-03
## PC.ae.C44.4_T4 7.600113e-04 -1.938337e-03 -1.033471e-03 2.456895e-03
## PC.ae.C44.5_T4 5.882511e-03 1.116060e-02 3.117408e-03 -3.089450e-03
## PC.ae.C44.6_T4 -9.508869e-04 1.469644e-02 -2.466235e-03 2.258728e-05
## SM..OH..C14.1_T4 -1.542697e-02 7.002952e-02 1.983956e-02 -1.705411e-02
## SM..OH..C16.1_T4 -1.379534e-02 3.588198e-02 1.847949e-03 -2.921447e-04
## SM..OH..C22.1_T4 -2.151326e-02 3.425312e-02 -2.459473e-02 -3.499432e-02
## SM..OH..C22.2_T4 -3.974369e-02 7.286604e-02 1.421135e-03 6.179643e-03
## SM..OH..C24.1_T4 9.928929e-04 1.517957e-03 -3.572265e-03 2.806066e-03
## SM.C16.0_T4 -1.134834e-02 6.174445e-02 -1.025548e-02 1.822182e-03
## SM.C16.1_T4 5.045642e-03 5.998958e-02 2.523099e-02 -5.777156e-03
## SM.C18.0_T4 -1.378445e-02 5.567233e-02 8.116304e-03 9.464677e-02
## SM.C18.1_T4 4.854515e-03 4.333883e-02 9.222658e-03 6.742431e-02
## SM.C20.2_T4 1.572441e-03 -6.764162e-05 2.570329e-03 6.081300e-03
## SM.C24.0_T4 8.498707e-03 7.228352e-02 -9.737863e-02 -2.733304e-02
## SM.C24.1_T4 -2.408041e-02 5.788023e-02 -3.911175e-02 8.341998e-02
## MEDDM_T5 -2.485949e-02 5.337201e-04 -9.345236e-03 1.251720e-02
## MEDCOL_T5 -2.485949e-02 5.337201e-04 -9.345236e-03 1.251720e-02
## MEDINF_T5 -1.048899e-02 1.977233e-02 -1.441494e-02 2.668031e-03
## MEDHTA_T5 -2.918376e-02 2.999828e-04 -1.017317e-02 1.323304e-02
## GLU_T5 -3.952935e-02 1.037616e-01 -5.266658e-03 -4.256215e-02
## INS_T5 8.395506e-02 6.624412e-02 4.408855e-02 1.831092e-02
## HOMA_T5 2.687709e-02 3.086458e-02 1.562355e-02 7.544188e-03
## HBA1C_T5 -5.793288e-03 -1.092596e-02 -7.588497e-03 -6.583269e-03
## HBA1C.mmol.mol_T5 -7.680488e-03 -2.833376e-02 -2.176754e-02 -3.148078e-02
## PESO_T5 2.906036e-02 4.643013e-02 -4.478437e-02 7.263127e-03
## bmi_T5 3.824518e-02 4.744518e-02 -8.318167e-03 6.341292e-03
## CC_T5 1.238147e-03 -2.140287e-03 -9.805890e-04 -2.261526e-03
## CINT_T5 7.231680e-03 -7.759999e-04 -4.462431e-02 -5.264374e-02
## CAD_T5 1.597828e-02 2.252583e-02 -2.621522e-02 -1.351566e-02
## TAD_T5 -1.960856e-03 -1.460174e-02 2.168666e-02 1.001229e-01
## TAS_T5 1.021284e-01 4.844299e-02 -3.775842e-02 9.063098e-03
## TG_T5 -2.577068e-02 6.992093e-02 5.405626e-03 3.745560e-03
## COL_T5 -2.873694e-02 3.389710e-02 3.114222e-02 5.926752e-02
## LDL_T5 -5.006949e-02 6.669428e-02 3.946045e-02 1.186871e-01
## HDL_T5 3.236660e-02 -6.538525e-02 3.295400e-03 -8.332770e-02
## VLDL_T5 9.604219e-03 1.606829e-02 -8.197180e-03 -1.099809e-02
## PCR_T5 -4.642461e-02 -3.640538e-02 7.671201e-02 3.031617e-02
## LEP_T5 -9.095652e-03 1.002778e-02 -2.487577e-02 -2.430228e-02
## ADIPO_T5 -5.256111e-02 3.200255e-03 1.770469e-02 -5.630951e-02
## GOT_T5 -3.996897e-02 -5.378180e-02 2.533926e-02 -5.661530e-03
## GPT_T5 -4.114532e-02 -9.170978e-03 1.101875e-01 -3.952310e-02
## GGT_T5 9.280545e-03 5.046701e-02 -8.710431e-02 -7.328212e-02
## URICO_T5 -2.500309e-02 -1.190546e-02 -5.669855e-02 8.849328e-03
## CREAT_T5 -3.593772e-04 -5.946997e-03 -6.053251e-03 6.503241e-03
## UREA_T5 -5.671266e-02 1.125324e-01 -2.051999e-02 -5.495309e-02
## HIERRO_T5 7.946052e-02 -3.492703e-03 -1.060768e-01 1.184823e-01
## TRANSF_T5 -5.675325e-02 -4.045847e-02 -2.349192e-02 -1.028695e-01
## FERR_T5 4.061778e-02 1.775466e-01 -3.408837e-02 4.493310e-02
## Ile_T5 -4.744230e-03 3.416190e-02 2.158775e-02 4.934370e-02
## Leu_T5 5.538367e-02 1.002973e-01 -2.474982e-02 2.825418e-02
## Val_T5 4.637766e-02 7.400654e-02 -2.282763e-02 -1.937136e-02
## Ala_T5 -1.242582e-02 2.085098e-02 2.978261e-02 -2.297073e-02
## Pro_T5 -4.515079e-02 5.507216e-02 -7.768863e-02 -6.946743e-02
## Gly_T5 -7.603728e-02 -2.309965e-02 6.282186e-04 -3.719495e-02
## Ser_T5 5.185764e-02 1.512557e-02 4.299579e-02 -2.213074e-02
## Trp_T5 -3.648639e-02 -8.089512e-03 -4.093965e-02 -1.845521e-02
## Phe_T5 2.935593e-02 4.240630e-02 -3.499738e-02 -6.556592e-02
## Met_T5 1.504686e-02 2.032075e-02 -2.329733e-02 4.407792e-02
## Orn_T5 1.470236e-02 7.378849e-02 2.373897e-02 2.829111e-02
## Arg_T5 1.445974e-02 -1.435278e-02 3.284360e-02 3.081044e-02
## His_T5 -2.675205e-02 1.299772e-02 5.569801e-02 -1.115980e-03
## Asn_T5 1.829372e-02 -1.391727e-02 6.854081e-02 1.111630e-02
## Asp_T5 9.575048e-03 -2.319255e-03 5.760203e-02 -1.994282e-02
## Glu_T5 -3.767578e-02 -1.472833e-02 -7.297185e-03 4.336002e-03
## Gln_T5 2.180545e-02 2.247513e-02 1.352163e-02 -2.296067e-02
## Cit_T5 -9.114602e-03 4.293070e-02 7.295185e-02 8.699757e-02
## Tyr_T5 1.813067e-02 6.752204e-03 -2.339712e-02 5.721315e-02
## Thr_T5 -2.889878e-02 2.230385e-02 -1.356296e-03 -5.512957e-02
## Lys_T5 6.275206e-02 7.557063e-02 -1.298873e-02 3.592717e-02
## Creatinine_T5 -1.239497e-02 -4.353115e-02 -5.551739e-02 -1.633700e-02
## Kynurenine_T5 2.201459e-02 -2.415973e-02 3.147094e-03 3.280698e-02
## Putrescine_T5 -7.771913e-02 -1.534178e-01 -2.537161e-02 -2.860440e-02
## Sarcosine_T5 -4.223474e-02 -3.931695e-02 -6.288087e-02 -1.711198e-02
## Serotonin_T5 1.500398e-02 7.218701e-02 6.833577e-03 2.940885e-02
## Taurine_T5 5.222365e-02 1.997622e-02 -5.136268e-02 2.681216e-03
## SDMA_T5 -8.097363e-04 -1.048345e-02 -5.619691e-03 2.116106e-03
## C0_T5 2.918709e-02 1.268671e-02 -4.663900e-02 1.405489e-04
## C2_T5 9.478820e-02 -5.249990e-02 -9.149130e-03 7.070315e-02
## C3.OH_T5 4.760343e-03 -1.601900e-03 -2.083323e-03 -1.133961e-03
## C6..C4.1.DC._T5 1.103696e-01 4.863310e-03 2.477830e-02 5.658258e-03
## C5.DC..C6.OH._T5 8.916492e-03 3.611930e-02 1.204673e-03 1.690111e-02
## C7.DC_T5 1.422211e-01 -2.623692e-02 9.061294e-02 -1.090740e-01
## C8_T5 1.065212e-02 -1.783245e-03 -4.476857e-03 -3.510608e-03
## C10_T5 1.289614e-02 -3.779227e-03 -6.250086e-03 -5.252513e-03
## C10.1_T5 3.343081e-02 1.165616e-02 -6.084810e-02 -1.293383e-02
## C10.2_T5 3.900630e-03 -2.050299e-03 -2.304963e-03 1.047730e-03
## C14.1_T5 5.226767e-03 -3.479450e-03 -2.958332e-03 1.317049e-03
## C14.2_T5 4.554015e-03 -2.814851e-03 -1.649126e-03 1.565950e-03
## C16.1_T5 3.647501e-03 -2.105469e-03 -1.477443e-03 1.911557e-03
## C16.2_T5 2.441999e-03 -3.122082e-03 -1.504574e-03 2.363438e-03
## C16.2.OH_T5 -4.064277e-02 1.025247e-02 1.145325e-02 -2.562320e-02
## C18.1_T5 3.415150e-03 -2.654211e-03 -2.036843e-03 3.174203e-03
## C18.1.OH_T5 2.876833e-03 -3.090390e-03 -1.440556e-03 2.384567e-03
## C18.2_T5 3.873392e-03 -2.523847e-03 -1.718223e-03 2.091942e-03
## lysoPC.a.C16.0_T5 -2.447750e-03 -1.574072e-02 3.961046e-02 -3.735949e-03
## lysoPC.a.C16.1_T5 1.337761e-02 1.798634e-02 2.156770e-02 1.578667e-02
## lysoPC.a.C17.0_T5 -2.095466e-02 -6.069610e-05 9.744515e-03 2.115434e-02
## lysoPC.a.C18.0_T5 -2.029664e-02 -2.339936e-02 2.503839e-02 -8.690914e-04
## lysoPC.a.C18.1_T5 -2.272586e-02 -2.123719e-02 6.543293e-02 2.017168e-02
## lysoPC.a.C18.2_T5 3.727262e-03 -5.443675e-02 5.953538e-02 -1.388793e-02
## lysoPC.a.C20.3_T5 1.538795e-02 -5.266097e-03 2.515450e-02 2.579262e-02
## lysoPC.a.C20.4_T5 -1.583335e-02 2.995010e-02 4.885155e-02 1.184439e-02
## lysoPC.a.C24.0_T5 5.718407e-04 -2.262104e-03 9.971491e-04 -3.330639e-03
## lysoPC.a.C26.0_T5 2.595772e-03 -1.990860e-03 6.235824e-03 1.827170e-03
## lysoPC.a.C26.1_T5 2.875726e-04 -1.939861e-04 3.612420e-03 5.147405e-03
## lysoPC.a.C28.0_T5 -5.498140e-02 5.707229e-02 2.068614e-02 -8.675595e-02
## lysoPC.a.C28.1_T5 1.555146e-03 -2.611273e-03 3.181606e-03 5.084160e-03
## PC.aa.C24.0_T5 -1.374629e-01 3.899012e-02 -4.679510e-03 4.290627e-02
## PC.aa.C28.1_T5 1.264262e-02 1.651834e-02 4.697052e-03 1.258869e-02
## PC.aa.C30.0_T5 9.509157e-03 -1.084036e-02 8.763277e-03 1.829344e-02
## PC.aa.C32.0_T5 7.060922e-03 -2.078748e-02 -2.678484e-02 3.781383e-02
## PC.aa.C32.1_T5 8.670366e-03 -8.392716e-03 -1.487628e-02 2.512545e-02
## PC.aa.C32.3_T5 2.635003e-03 -2.539982e-03 -1.971844e-03 2.569586e-05
## PC.aa.C34.1_T5 -1.655541e-03 -4.006371e-02 2.923560e-02 1.562440e-02
## PC.aa.C34.2_T5 1.945522e-02 -7.030490e-02 1.741276e-02 -1.957072e-02
## PC.aa.C34.3_T5 2.436174e-02 -7.569831e-03 -1.129910e-02 1.641046e-02
## PC.aa.C34.4_T5 1.111186e-03 -3.123709e-03 -4.724544e-04 4.223478e-03
## PC.aa.C36.0_T5 -2.758176e-03 4.000139e-03 1.463984e-03 -2.471606e-02
## PC.aa.C36.1_T5 6.005389e-02 -3.790845e-02 1.028768e-02 -2.585613e-02
## PC.aa.C36.2_T5 3.122550e-02 -5.583563e-02 -2.128699e-02 -4.580087e-02
## PC.aa.C36.3_T5 3.092294e-02 -4.437962e-02 4.287035e-03 3.552064e-02
## PC.aa.C36.4_T5 -1.712293e-02 -1.462788e-02 2.110505e-02 -5.582300e-03
## PC.aa.C36.5_T5 -6.253055e-02 3.849062e-02 1.659640e-02 5.373327e-02
## PC.aa.C38.0_T5 -6.146516e-03 2.553412e-02 4.828843e-03 -4.908217e-02
## PC.aa.C38.1_T5 -1.419302e-02 -3.219448e-03 4.633061e-03 2.683355e-04
## PC.aa.C38.3_T5 1.126516e-02 -1.494940e-02 -1.676491e-02 1.577700e-02
## PC.aa.C38.4_T5 -3.247244e-02 -1.391018e-02 1.833673e-03 1.766142e-02
## PC.aa.C38.5_T5 -1.466413e-02 3.121508e-02 2.303888e-02 5.831864e-02
## PC.aa.C38.6_T5 6.169770e-03 1.461959e-02 2.817368e-02 -5.650861e-02
## PC.aa.C40.1_T5 -8.137150e-02 3.068700e-02 -4.029423e-02 -6.065788e-02
## PC.aa.C40.2_T5 -3.256298e-03 1.681962e-03 6.628718e-03 1.215998e-03
## PC.aa.C40.3_T5 -2.242938e-03 2.249144e-03 6.600397e-03 -6.786628e-04
## PC.aa.C40.4_T5 8.997859e-04 1.773309e-04 6.020058e-03 8.165618e-03
## PC.aa.C40.5_T5 -1.923452e-03 1.516576e-03 1.482989e-02 3.027891e-02
## PC.aa.C40.6_T5 -1.625425e-02 -5.754693e-04 9.051873e-04 -8.580777e-02
## PC.aa.C42.0_T5 -5.456340e-03 2.653934e-03 -4.780565e-03 -6.800051e-03
## PC.aa.C42.1_T5 -2.667995e-03 1.410918e-03 -1.772976e-03 -5.731648e-04
## PC.aa.C42.2_T5 -1.848809e-03 2.236950e-03 2.196298e-03 1.033593e-03
## PC.aa.C42.4_T5 -1.995113e-03 2.021471e-05 3.012460e-03 1.417566e-03
## PC.aa.C42.5_T5 -2.325950e-03 -5.382566e-05 1.419426e-03 7.269057e-04
## PC.aa.C42.6_T5 -2.188643e-03 1.392983e-03 5.933789e-02 2.240415e-02
## PC.ae.C30.0_T5 1.639049e-02 -3.764746e-03 2.840548e-02 2.381265e-02
## PC.ae.C32.1_T5 -6.331607e-03 -1.020842e-02 -1.966322e-03 -1.619918e-03
## PC.ae.C32.2_T5 -3.291830e-04 2.119178e-04 -3.426393e-03 -4.246982e-03
## PC.ae.C34.0_T5 5.671627e-03 -6.942966e-04 -2.063212e-03 8.925220e-03
## PC.ae.C34.1_T5 8.039200e-03 -1.171585e-02 7.295347e-03 3.691143e-02
## PC.ae.C34.2_T5 1.066536e-03 -2.879997e-02 9.256011e-03 3.257650e-03
## PC.ae.C34.3_T5 2.657153e-03 -6.043150e-02 1.101527e-02 -2.736713e-02
## PC.ae.C36.0_T5 7.395104e-04 -7.802981e-05 2.460101e-03 5.700756e-03
## PC.ae.C36.1_T5 -1.271832e-02 1.896040e-02 2.415752e-02 1.340672e-02
## PC.ae.C36.2_T5 1.485869e-02 -2.667512e-02 6.654433e-03 2.124652e-02
## PC.ae.C36.3_T5 6.701634e-03 -3.444253e-02 -8.827605e-05 -7.646717e-03
## PC.ae.C36.4_T5 1.716565e-02 -8.999339e-03 -7.533279e-03 -1.569510e-02
## PC.ae.C36.5_T5 -2.588521e-02 -1.883164e-02 8.721595e-03 -6.864960e-02
## PC.ae.C38.0_T5 -5.211221e-03 5.543637e-03 4.594996e-03 -2.207065e-03
## PC.ae.C38.2_T5 -1.306292e-02 7.192535e-03 2.210734e-02 -7.937242e-03
## PC.ae.C38.3_T5 -2.048196e-02 -5.795106e-03 -6.004492e-03 2.709467e-02
## PC.ae.C38.4_T5 -1.273895e-02 -1.202732e-02 3.030520e-03 2.812041e-02
## PC.ae.C38.5_T5 3.758560e-03 1.103210e-02 -2.574631e-02 -6.737946e-02
## PC.ae.C38.6_T5 6.310680e-03 -7.039022e-04 -6.450501e-03 -6.197646e-02
## PC.ae.C40.1_T5 -6.764192e-03 4.466229e-03 6.426117e-03 -5.130751e-03
## PC.ae.C40.2_T5 -6.978808e-03 1.528969e-02 -1.656042e-03 1.027703e-02
## PC.ae.C40.3_T5 -2.380573e-02 5.747370e-04 -3.554878e-03 1.564210e-02
## PC.ae.C40.4_T5 -2.403042e-02 1.119413e-02 9.393846e-03 1.470964e-02
## PC.ae.C40.5_T5 -3.285758e-02 -2.736156e-03 -2.279881e-03 4.065757e-03
## PC.ae.C40.6_T5 -1.213788e-02 9.744098e-04 2.325740e-04 1.473291e-03
## PC.ae.C42.1_T5 -2.808287e-03 -6.335323e-04 3.211426e-03 3.844859e-03
## PC.ae.C42.2_T5 -1.681200e-03 -1.837986e-03 3.116783e-03 6.392945e-03
## PC.ae.C42.3_T5 -4.762189e-03 -4.494899e-04 6.350234e-03 7.672825e-04
## PC.ae.C42.4_T5 -6.943363e-03 -1.624303e-04 3.564018e-03 5.257609e-03
## PC.ae.C42.5_T5 -4.122986e-02 2.159659e-03 -7.417321e-03 3.205233e-03
## PC.ae.C44.3_T5 1.001661e-03 3.166641e-04 8.738107e-04 1.637305e-03
## PC.ae.C44.4_T5 -3.080457e-04 -3.728130e-03 -1.048451e-03 5.468005e-03
## PC.ae.C44.5_T5 -2.629455e-02 4.645727e-03 -1.307019e-02 -8.843564e-03
## PC.ae.C44.6_T5 -1.927815e-02 9.183061e-03 -1.390156e-02 -9.158867e-03
## SM..OH..C14.1_T5 2.329571e-02 1.113566e-02 -1.288062e-02 1.854883e-02
## SM..OH..C16.1_T5 1.015557e-02 1.339242e-03 -3.242055e-03 1.838197e-02
## SM..OH..C22.1_T5 9.607288e-03 -3.074351e-02 2.668303e-02 9.173650e-04
## SM..OH..C22.2_T5 9.790622e-03 -2.825564e-02 1.869615e-02 -5.797061e-03
## SM..OH..C24.1_T5 3.649786e-03 -4.087345e-03 3.821284e-03 5.793181e-03
## SM.C16.0_T5 9.185154e-03 -1.115769e-02 1.773023e-02 5.532379e-03
## SM.C16.1_T5 9.166894e-02 -2.743497e-02 9.657495e-04 -5.794306e-02
## SM.C18.0_T5 6.963746e-02 -2.260284e-02 -3.155269e-02 4.799775e-02
## SM.C18.1_T5 8.156588e-02 -3.190616e-02 -3.437912e-02 -4.845540e-02
## SM.C20.2_T5 4.267424e-03 -3.564258e-03 2.697093e-04 3.545918e-03
## SM.C24.0_T5 -1.683201e-02 -3.826769e-02 6.505490e-02 -1.778616e-02
## SM.C24.1_T5 -3.016514e-02 -3.450708e-02 2.368949e-02 3.171158e-02
## PC37 PC38 PC39
## GLU_T0 2.117568e-03 -2.521041e-02 1.188556e-02
## INS_T0 4.735738e-02 5.755430e-02 3.592134e-02
## HOMA_T0 3.730470e-02 2.761675e-02 -1.589256e-02
## HBA1C_T0 -1.202209e-02 -1.218748e-02 6.074584e-02
## HBA1C.mmol.mol_T0 -4.274389e-02 -4.418981e-02 -3.919113e-02
## PESO_T0 3.539852e-02 -1.092509e-02 1.237722e-03
## bmi_T0 3.112865e-02 3.099812e-02 -6.598075e-02
## CC_T0 2.029228e-03 -2.695357e-03 -7.212352e-02
## CINT_T0 3.978062e-02 2.895238e-02 5.912401e-02
## CAD_T0 2.686217e-02 5.245300e-02 -4.644209e-02
## TAD_T0 -9.794284e-02 5.137471e-02 2.597234e-02
## TAS_T0 -9.729626e-02 6.761506e-02 -9.247554e-02
## TG_T0 3.590398e-02 -1.726802e-03 5.298343e-02
## COL_T0 9.748518e-03 7.010446e-02 4.326379e-02
## LDL_T0 5.916170e-02 7.519742e-02 -4.162080e-03
## HDL_T0 -1.289324e-01 -6.585384e-02 1.423096e-01
## VLDL_T0 3.648229e-02 -2.061246e-03 -9.780679e-03
## PCR_T0 5.733303e-02 1.065152e-01 -5.839563e-02
## LEP_T0 -6.585011e-02 -6.758918e-02 -2.724369e-02
## ADIPO_T0 -2.218169e-02 7.115386e-02 1.725535e-03
## GOT_T0 1.259204e-01 -9.916690e-02 -3.365524e-02
## GPT_T0 1.323132e-01 -1.087630e-01 6.391437e-02
## GGT_T0 3.497811e-02 -3.110783e-02 4.862459e-03
## URICO_T0 7.976503e-02 -2.342045e-02 9.893430e-02
## CREAT_T0 1.573650e-02 -5.510170e-03 -6.715642e-02
## UREA_T0 -9.660382e-02 -4.878547e-03 -6.843538e-02
## HIERRO_T0 -6.993569e-02 1.047185e-01 8.234527e-03
## TRANSF_T0 -5.151651e-02 3.088880e-02 2.227588e-02
## FERR_T0 4.918000e-02 2.243439e-03 1.690832e-02
## Ile_T0 -5.665520e-02 -3.847636e-03 3.702383e-02
## Leu_T0 -2.855698e-02 2.860293e-02 2.402649e-02
## Val_T0 -6.859296e-02 3.747386e-02 -1.315716e-02
## Ala_T0 -3.605949e-02 2.089455e-02 2.584557e-02
## Pro_T0 -1.259067e-02 8.885843e-02 4.479633e-03
## Gly_T0 -1.276684e-02 5.721028e-02 -2.470784e-02
## Ser_T0 -6.756119e-02 4.197696e-02 -3.156729e-02
## Trp_T0 1.063681e-01 -3.594951e-02 -1.116742e-01
## Phe_T0 6.915327e-02 5.799658e-02 1.500370e-02
## Met_T0 1.819382e-02 -6.126613e-03 -9.729197e-03
## Orn_T0 -4.678186e-02 5.323088e-02 4.304997e-03
## Arg_T0 -4.916214e-02 7.919409e-03 -2.783388e-03
## His_T0 -2.421091e-04 2.062609e-02 9.193333e-03
## Asn_T0 3.476578e-02 -6.595617e-02 -1.765577e-03
## Asp_T0 4.603383e-03 -2.789566e-02 4.835413e-03
## Glu_T0 -1.325426e-02 -2.806577e-03 -5.054135e-05
## Gln_T0 -6.081824e-02 4.119007e-02 5.244894e-03
## Cit_T0 8.296081e-02 8.214910e-04 -4.194319e-03
## Tyr_T0 -4.770406e-03 5.084074e-02 1.857719e-02
## Thr_T0 -8.384575e-03 -3.798469e-02 6.323290e-03
## Lys_T0 -2.094840e-02 -2.341168e-02 -3.943616e-03
## Creatinine_T0 1.059260e-01 -6.953307e-02 -1.704559e-02
## Kynurenine_T0 6.891407e-03 6.412697e-02 5.492529e-02
## Putrescine_T0 1.601549e-02 -9.895975e-02 -1.732720e-02
## Sarcosine_T0 2.976800e-02 -1.190703e-01 -3.421078e-02
## Serotonin_T0 1.492662e-02 6.680367e-02 2.224684e-02
## Taurine_T0 6.044062e-02 -6.615121e-03 1.291062e-02
## SDMA_T0 5.632207e-03 1.703686e-03 -3.500861e-02
## C0_T0 4.261089e-02 -6.154687e-02 8.243574e-03
## C2_T0 1.055701e-01 6.564921e-02 2.025772e-02
## C3.OH_T0 5.986354e-04 1.433784e-03 1.306474e-02
## C6..C4.1.DC._T0 1.981837e-02 1.635077e-02 2.055384e-03
## C5.DC..C6.OH._T0 1.286246e-01 5.677075e-02 5.562933e-03
## C7.DC_T0 -1.218531e-01 -1.187377e-01 2.954656e-03
## C8_T0 3.679502e-03 6.842985e-03 -6.464603e-02
## C10_T0 -3.015875e-03 2.678919e-03 -2.560235e-04
## C10.1_T0 -2.147728e-05 2.603568e-03 3.250285e-02
## C10.2_T0 -8.597385e-04 -6.447458e-04 -5.370984e-02
## C14.1_T0 1.640237e-04 3.069930e-04 1.407527e-03
## C14.2_T0 7.321855e-04 -1.723548e-04 5.500712e-02
## C16.1_T0 -1.973569e-04 -1.600472e-03 7.641816e-03
## C16.2_T0 1.089810e-03 -1.636806e-03 -3.070995e-02
## C16.2.OH_T0 7.361522e-04 -1.136436e-03 1.286728e-02
## C18.1_T0 4.878185e-03 -9.030452e-04 -7.732176e-02
## C18.1.OH_T0 1.305695e-03 -1.113823e-03 1.817323e-03
## C18.2_T0 1.517477e-03 -2.168426e-04 6.837206e-02
## lysoPC.a.C16.0_T0 5.925479e-02 -2.323813e-02 -7.086826e-03
## lysoPC.a.C16.1_T0 1.509978e-03 -3.239819e-03 -1.722575e-02
## lysoPC.a.C17.0_T0 8.973994e-03 5.384810e-03 2.803392e-02
## lysoPC.a.C18.0_T0 3.706186e-02 -1.898802e-02 1.464091e-02
## lysoPC.a.C18.1_T0 8.814201e-02 -3.374443e-02 1.153001e-02
## lysoPC.a.C18.2_T0 9.539700e-03 -8.678938e-02 3.232488e-04
## lysoPC.a.C20.3_T0 5.478471e-02 6.289970e-02 6.347960e-02
## lysoPC.a.C20.4_T0 8.204136e-02 -6.089857e-03 1.436889e-02
## lysoPC.a.C24.0_T0 -4.935401e-05 -3.591564e-04 2.601754e-02
## lysoPC.a.C26.0_T0 6.561480e-02 -3.271140e-03 2.421962e-02
## lysoPC.a.C26.1_T0 -1.187051e-02 -3.347539e-03 3.322706e-02
## lysoPC.a.C28.0_T0 9.106006e-03 6.883127e-02 -3.886552e-02
## lysoPC.a.C28.1_T0 -6.673127e-03 -7.640753e-03 -8.165740e-03
## PC.aa.C24.0_T0 -1.097816e-01 8.300824e-02 -2.743200e-02
## PC.aa.C28.1_T0 -1.216964e-02 -1.994863e-02 3.889700e-02
## PC.aa.C30.0_T0 1.339372e-02 -2.561169e-03 5.177903e-02
## PC.aa.C32.0_T0 3.847240e-02 1.782135e-02 -5.157388e-02
## PC.aa.C32.1_T0 3.356918e-02 -1.472330e-02 -4.457246e-04
## PC.aa.C32.3_T0 -2.615994e-03 3.783848e-05 -5.726431e-02
## PC.aa.C34.1_T0 7.273197e-02 -6.059101e-02 1.051268e-03
## PC.aa.C34.2_T0 2.404871e-02 -4.242063e-02 -2.453367e-02
## PC.aa.C34.3_T0 -3.286924e-02 -4.395346e-02 9.134192e-03
## PC.aa.C34.4_T0 -3.461794e-03 -1.009486e-02 1.154565e-02
## PC.aa.C36.0_T0 -2.068842e-02 -1.142615e-02 -3.900238e-02
## PC.aa.C36.1_T0 3.755563e-02 -3.724335e-03 4.302759e-04
## PC.aa.C36.2_T0 -5.722536e-02 -9.240582e-02 -7.058518e-03
## PC.aa.C36.3_T0 9.451291e-03 7.462151e-02 -1.319554e-03
## PC.aa.C36.4_T0 -2.215336e-02 -1.034448e-02 -3.266063e-03
## PC.aa.C36.5_T0 -5.946546e-02 -4.020780e-02 -1.225698e-02
## PC.aa.C38.0_T0 -7.878786e-03 1.893714e-02 -1.745074e-02
## PC.aa.C38.1_T0 -3.444389e-02 -2.722567e-02 -6.153721e-02
## PC.aa.C38.3_T0 -1.647406e-03 8.804287e-02 4.788482e-03
## PC.aa.C38.4_T0 -3.785578e-02 1.395713e-02 1.466887e-03
## PC.aa.C38.5_T0 -5.291211e-02 -6.284827e-02 9.780684e-03
## PC.aa.C38.6_T0 -6.168039e-03 -4.067656e-02 -1.068625e-02
## PC.aa.C40.1_T0 3.577010e-03 -3.384130e-02 -4.386854e-02
## PC.aa.C40.2_T0 -2.629475e-03 1.237590e-03 4.113296e-02
## PC.aa.C40.3_T0 -3.463164e-03 6.695665e-03 -4.002757e-02
## PC.aa.C40.4_T0 -1.772288e-02 5.816073e-03 -6.371919e-02
## PC.aa.C40.5_T0 -3.779104e-02 -2.662079e-02 7.157684e-03
## PC.aa.C40.6_T0 1.732900e-02 5.787835e-03 -9.874514e-03
## PC.aa.C42.0_T0 -1.320910e-03 4.383329e-03 -2.555865e-02
## PC.aa.C42.1_T0 -1.085484e-03 -2.229339e-03 -3.160766e-02
## PC.aa.C42.2_T0 7.101416e-04 -3.054815e-03 -6.288097e-02
## PC.aa.C42.4_T0 -2.311571e-03 3.919037e-04 -1.670791e-02
## PC.aa.C42.5_T0 2.356003e-04 -1.754804e-03 1.602198e-02
## PC.aa.C42.6_T0 1.716956e-01 -3.695328e-03 -5.587172e-03
## PC.ae.C30.0_T0 3.716023e-03 -3.253904e-03 -3.162962e-02
## PC.ae.C32.1_T0 9.050604e-03 1.161370e-03 3.852873e-02
## PC.ae.C32.2_T0 -2.336676e-03 -1.013142e-03 1.426887e-02
## PC.ae.C34.0_T0 7.061533e-03 2.813911e-03 -4.504068e-02
## PC.ae.C34.1_T0 3.850006e-02 -1.271808e-02 -3.097239e-02
## PC.ae.C34.2_T0 -5.391320e-03 -3.329775e-02 2.285789e-02
## PC.ae.C34.3_T0 -4.600721e-02 -6.073001e-02 -2.696889e-02
## PC.ae.C36.0_T0 9.182838e-03 -4.672445e-03 7.306422e-02
## PC.ae.C36.1_T0 -4.298484e-03 1.774548e-03 2.773847e-02
## PC.ae.C36.2_T0 -2.912022e-02 -1.508869e-02 -3.357649e-02
## PC.ae.C36.3_T0 -2.393613e-02 4.406421e-03 4.579653e-02
## PC.ae.C36.4_T0 -2.828252e-02 -7.294735e-02 1.364791e-02
## PC.ae.C36.5_T0 -3.705620e-02 -6.590852e-02 -3.439365e-02
## PC.ae.C38.0_T0 -5.308652e-03 -9.878335e-03 5.384931e-02
## PC.ae.C38.2_T0 -1.081784e-02 1.712723e-03 3.035704e-02
## PC.ae.C38.3_T0 -3.702372e-03 1.308539e-02 4.319602e-03
## PC.ae.C38.4_T0 -1.975884e-02 2.066726e-02 3.521426e-02
## PC.ae.C38.5_T0 4.012896e-03 1.220470e-02 1.746218e-02
## PC.ae.C38.6_T0 -2.287658e-02 -1.326490e-02 -7.524696e-02
## PC.ae.C40.1_T0 -1.079452e-03 -1.257403e-02 -5.175535e-02
## PC.ae.C40.2_T0 -4.167037e-03 6.366996e-03 6.252359e-03
## PC.ae.C40.3_T0 -8.524891e-03 8.644925e-03 -5.459263e-03
## PC.ae.C40.4_T0 7.366403e-04 1.336838e-03 3.886927e-02
## PC.ae.C40.5_T0 -2.481760e-03 1.802017e-02 5.414655e-02
## PC.ae.C40.6_T0 -1.301931e-02 1.603256e-02 -7.367653e-02
## PC.ae.C42.1_T0 -6.175366e-03 -7.021138e-04 -6.542200e-02
## PC.ae.C42.2_T0 7.939073e-04 -1.288031e-03 4.501267e-02
## PC.ae.C42.3_T0 -2.101872e-03 -5.563096e-03 6.188597e-02
## PC.ae.C42.4_T0 -1.086860e-02 1.395128e-03 -6.041033e-02
## PC.ae.C42.5_T0 -1.746493e-03 2.051658e-02 -2.151526e-02
## PC.ae.C44.3_T0 -2.235193e-03 -9.606515e-04 5.805768e-02
## PC.ae.C44.4_T0 2.435699e-03 6.610200e-04 -3.489276e-02
## PC.ae.C44.5_T0 2.196388e-02 3.565254e-02 1.974218e-02
## PC.ae.C44.6_T0 -7.199350e-03 1.654272e-02 -5.522298e-02
## SM..OH..C14.1_T0 2.613352e-02 -2.225322e-02 6.186348e-02
## SM..OH..C16.1_T0 1.028467e-02 -6.051118e-04 2.270264e-02
## SM..OH..C22.1_T0 -1.935843e-02 1.601693e-02 -6.439420e-02
## SM..OH..C22.2_T0 2.130361e-02 -2.950720e-02 -1.476653e-02
## SM..OH..C24.1_T0 -1.617207e-03 -2.862300e-03 -1.290743e-02
## SM.C16.0_T0 -4.935923e-02 3.928988e-02 1.150297e-02
## SM.C16.1_T0 -1.056024e-02 -1.756543e-02 2.789298e-02
## SM.C18.0_T0 -2.919638e-02 -1.507887e-02 3.025550e-02
## SM.C18.1_T0 -1.467773e-02 -5.153687e-02 2.568638e-02
## SM.C20.2_T0 2.869002e-03 -1.685010e-04 7.745966e-02
## SM.C24.0_T0 -2.526073e-02 2.612788e-02 -4.224493e-02
## SM.C24.1_T0 -1.565848e-02 4.674694e-02 -4.357387e-03
## MEDDM_T2 1.727047e-03 -1.841151e-03 5.588307e-02
## MEDCOL_T2 1.727047e-03 -1.841151e-03 5.588307e-02
## MEDINF_T2 -2.176326e-02 -3.830507e-03 -5.284287e-02
## MEDHTA_T2 -1.326789e-02 -3.765270e-03 -4.552373e-02
## GLU_T2 -1.702276e-02 -6.819998e-03 -1.710042e-03
## INS_T2 -1.303917e-01 -2.922503e-02 2.150953e-02
## HOMA_T2 -6.321133e-02 -2.174876e-02 -1.722385e-03
## HBA1C_T2 -1.586130e-02 -2.163517e-02 8.898172e-04
## HBA1C.mmol.mol_T2 -7.162768e-02 -9.539172e-02 -3.290016e-03
## PESO_T2 1.206454e-02 -2.455943e-02 -1.989579e-02
## bmi_T2 7.209663e-03 2.060288e-02 5.070781e-03
## CC_T2 5.355984e-03 -8.068842e-03 4.893326e-02
## CINT_T2 4.104565e-02 -7.716923e-02 -1.523020e-02
## CAD_T2 -1.972592e-02 1.848454e-02 4.275064e-03
## TAD_T2 1.088555e-01 -2.944152e-02 -1.432875e-02
## TAS_T2 7.368593e-02 6.759732e-02 -1.624227e-02
## TG_T2 1.892871e-01 -3.027067e-02 -7.251392e-03
## COL_T2 3.854468e-02 2.546393e-02 5.251871e-03
## LDL_T2 2.913013e-02 -9.520871e-03 -8.599329e-03
## HDL_T2 -9.008435e-03 1.082523e-01 5.690609e-04
## VLDL_T2 -2.268370e-03 7.069026e-03 2.517383e-03
## PCR_T2 -7.241760e-02 9.241763e-03 -3.998204e-02
## LEP_T2 -1.856766e-02 4.635220e-02 1.435715e-02
## ADIPO_T2 -3.405759e-02 1.502118e-02 -5.722906e-02
## GOT_T2 -4.537244e-02 7.891785e-02 -9.798520e-03
## GPT_T2 2.267625e-02 9.915561e-02 -1.686946e-02
## GGT_T2 6.597258e-02 3.079343e-03 4.608398e-04
## URICO_T2 5.875860e-04 5.242098e-02 4.970257e-02
## CREAT_T2 2.589429e-02 -1.293669e-03 6.028493e-02
## UREA_T2 -2.287124e-02 -5.922424e-02 -3.088712e-03
## HIERRO_T2 -1.499520e-01 1.203048e-02 -1.033211e-02
## TRANSF_T2 -4.230566e-03 7.421124e-02 5.239191e-03
## FERR_T2 -1.052530e-01 -5.425341e-02 1.055970e-02
## Ile_T2 -3.219563e-02 6.030086e-02 3.564639e-03
## Leu_T2 -4.583057e-02 1.089027e-01 -5.822811e-03
## Val_T2 -2.366135e-02 9.495871e-02 5.597699e-03
## Ala_T2 9.739590e-03 -3.804099e-02 2.718231e-04
## Pro_T2 1.151864e-02 5.044763e-02 1.532805e-03
## Gly_T2 5.850771e-02 5.090638e-02 -1.088078e-02
## Ser_T2 -1.104827e-01 -6.799471e-02 -1.896526e-03
## Trp_T2 2.855863e-02 9.707229e-03 1.480887e-04
## Phe_T2 -3.982923e-02 -1.903528e-02 -5.924679e-03
## Met_T2 4.976932e-02 2.071089e-02 4.600484e-03
## Orn_T2 4.238182e-03 1.155833e-01 5.493727e-03
## Arg_T2 -5.261855e-02 -8.238660e-02 -2.501668e-02
## His_T2 -2.110801e-02 1.091054e-01 -2.388076e-03
## Asn_T2 -4.886323e-02 -2.891011e-02 -3.525920e-03
## Asp_T2 -5.744949e-02 -5.385716e-04 2.473827e-03
## Glu_T2 -3.755762e-02 -2.057565e-02 1.525296e-02
## Gln_T2 7.848087e-04 -9.487935e-02 8.002747e-03
## Cit_T2 1.081399e-01 -1.650974e-02 1.717362e-03
## Tyr_T2 -1.416134e-02 -4.207483e-02 2.108622e-03
## Thr_T2 -4.209889e-03 5.161762e-02 -7.123486e-03
## Lys_T2 -9.709277e-03 3.470195e-02 -1.026858e-02
## Creatinine_T2 1.037285e-01 -7.119747e-02 -7.315987e-03
## Kynurenine_T2 -1.150693e-02 3.233985e-02 -5.422998e-02
## Putrescine_T2 -1.593938e-02 -7.879843e-02 4.708489e-03
## Sarcosine_T2 8.057070e-02 -7.749958e-02 -3.364467e-02
## Serotonin_T2 5.707764e-02 -1.849802e-02 -2.544118e-02
## Taurine_T2 2.171340e-02 8.307754e-04 1.837967e-02
## SDMA_T2 2.114782e-02 4.684009e-04 -3.067325e-02
## C0_T2 -1.310058e-02 -7.692354e-02 5.802730e-03
## C2_T2 3.723289e-02 9.101173e-02 -2.261781e-02
## C3.OH_T2 -3.452144e-03 -1.557019e-03 4.676120e-02
## C6..C4.1.DC._T2 1.995521e-02 -1.349176e-01 9.291476e-04
## C5.DC..C6.OH._T2 5.752213e-02 2.270151e-02 -7.948905e-03
## C7.DC_T2 9.875934e-02 5.825032e-02 3.622388e-02
## C8_T2 -1.039434e-02 -8.291192e-03 7.850238e-02
## C10_T2 -8.599983e-03 -1.280944e-02 7.259299e-02
## C10.1_T2 -3.532661e-04 -2.172061e-03 -5.073352e-02
## C10.2_T2 -5.327587e-04 -3.737213e-03 -3.451799e-02
## C14.1_T2 -1.824881e-03 -2.581232e-03 3.572699e-02
## C14.2_T2 7.702311e-04 -6.402643e-04 -1.980219e-02
## C16.1_T2 -1.240068e-04 -2.992925e-03 -4.424140e-02
## C16.2_T2 9.781930e-04 -2.903796e-03 4.588878e-02
## C16.2.OH_T2 1.839353e-03 -2.686897e-03 -6.706899e-02
## C18.1_T2 2.812620e-03 -2.407605e-03 4.485224e-04
## C18.1.OH_T2 6.939188e-04 -8.376824e-04 5.140138e-02
## C18.2_T2 1.148901e-03 -2.671858e-03 -5.285828e-03
## lysoPC.a.C14.0_T2 -2.647628e-02 1.024919e-01 3.246854e-02
## lysoPC.a.C16.0_T2 2.817785e-02 2.346681e-02 4.874171e-03
## lysoPC.a.C16.1_T2 -1.035376e-02 3.627476e-02 9.619556e-03
## lysoPC.a.C17.0_T2 1.941928e-02 1.619759e-02 -8.633109e-02
## lysoPC.a.C18.0_T2 -3.732822e-03 5.266436e-03 4.245790e-03
## lysoPC.a.C18.1_T2 6.983115e-03 2.584835e-02 6.756472e-03
## lysoPC.a.C18.2_T2 1.989842e-02 2.253930e-02 -1.038181e-03
## lysoPC.a.C20.3_T2 -3.229930e-02 4.295242e-03 -7.805769e-02
## lysoPC.a.C20.4_T2 -1.660033e-02 4.693672e-02 -2.013690e-02
## lysoPC.a.C24.0_T2 -5.301523e-03 -9.899592e-03 5.177497e-02
## lysoPC.a.C26.0_T2 4.387996e-02 -2.259834e-02 3.849744e-02
## lysoPC.a.C26.1_T2 -1.058859e-02 -1.151435e-02 7.659622e-02
## lysoPC.a.C28.0_T2 -1.401613e-02 1.166300e-01 4.270553e-04
## lysoPC.a.C28.1_T2 -4.376575e-03 -5.651963e-03 -7.337138e-02
## PC.aa.C24.0_T2 4.746064e-02 -1.340958e-01 8.989778e-03
## PC.aa.C28.1_T2 1.730855e-03 1.453062e-02 -2.003571e-02
## PC.aa.C30.0_T2 -1.267358e-02 6.077773e-03 6.599823e-02
## PC.aa.C32.0_T2 -1.227860e-02 1.204394e-02 -1.980014e-02
## PC.aa.C32.1_T2 -4.969026e-02 8.158186e-03 -4.479777e-03
## PC.aa.C32.3_T2 1.226557e-03 3.394883e-04 -2.018918e-02
## PC.aa.C34.1_T2 2.195739e-02 -1.058371e-01 6.322882e-04
## PC.aa.C34.2_T2 3.138937e-02 -7.369280e-02 -5.698837e-03
## PC.aa.C34.3_T2 5.161049e-06 -2.560154e-02 -2.555899e-02
## PC.aa.C34.4_T2 1.606635e-04 1.816655e-03 4.515618e-02
## PC.aa.C36.0_T2 -6.701135e-03 -1.226948e-02 -4.084672e-02
## PC.aa.C36.1_T2 -1.130983e-02 -4.699136e-02 -1.791836e-02
## PC.aa.C36.2_T2 3.546241e-02 -1.035247e-01 3.665310e-03
## PC.aa.C36.3_T2 1.798845e-03 -9.057602e-04 7.940384e-03
## PC.aa.C36.4_T2 -1.189059e-02 7.964878e-02 -1.265546e-02
## PC.aa.C36.5_T2 4.502116e-02 2.123708e-02 1.521398e-02
## PC.aa.C38.0_T2 -8.571626e-03 -3.534871e-03 4.417925e-02
## PC.aa.C38.1_T2 -2.015076e-03 -3.588653e-02 -3.932565e-02
## PC.aa.C38.3_T2 -4.993500e-02 -1.490546e-02 -1.249396e-03
## PC.aa.C38.4_T2 -2.590494e-02 6.308856e-02 5.387572e-03
## PC.aa.C38.5_T2 -2.064996e-02 2.811827e-02 -1.844700e-02
## PC.aa.C38.6_T2 1.727803e-02 -2.955702e-02 -1.957358e-02
## PC.aa.C40.1_T2 -8.562184e-02 -3.962671e-02 -3.555017e-02
## PC.aa.C40.2_T2 -1.171387e-02 -7.428720e-03 7.568071e-02
## PC.aa.C40.3_T2 -1.821950e-02 -6.136713e-03 6.545997e-02
## PC.aa.C40.4_T2 -4.317749e-02 -6.844827e-03 -6.031256e-02
## PC.aa.C40.5_T2 -2.755114e-02 -2.115073e-02 -3.325989e-02
## PC.aa.C40.6_T2 1.322567e-02 -2.702702e-02 -7.136506e-03
## PC.aa.C42.0_T2 -6.635591e-03 -5.009915e-03 7.144013e-02
## PC.aa.C42.1_T2 -4.064263e-03 -3.019624e-03 4.380213e-02
## PC.aa.C42.2_T2 -4.581931e-03 -2.731589e-03 -2.056679e-02
## PC.aa.C42.4_T2 -4.729283e-03 -2.450667e-03 6.637156e-02
## PC.aa.C42.5_T2 -3.058318e-03 -1.932134e-03 -6.764001e-02
## PC.aa.C42.6_T2 9.721978e-02 1.748502e-02 -4.278162e-02
## PC.ae.C30.0_T2 2.194231e-02 -4.091060e-02 -4.827815e-02
## PC.ae.C32.1_T2 9.492724e-03 -1.189321e-02 5.961662e-02
## PC.ae.C32.2_T2 7.885851e-04 3.516164e-03 -3.020032e-02
## PC.ae.C34.0_T2 3.202054e-03 -8.624313e-04 7.373969e-02
## PC.ae.C34.1_T2 2.349103e-02 8.698817e-04 -3.874838e-02
## PC.ae.C34.2_T2 3.435687e-03 -5.340939e-02 3.191004e-02
## PC.ae.C34.3_T2 6.389125e-03 -2.492512e-02 -1.043066e-03
## PC.ae.C36.0_T2 1.258673e-03 -1.230275e-03 -6.859033e-02
## PC.ae.C36.1_T2 -2.476374e-02 -1.273553e-02 -5.882298e-02
## PC.ae.C36.2_T2 2.744198e-02 -4.610516e-03 3.052909e-02
## PC.ae.C36.3_T2 -9.219721e-03 -1.224979e-02 -7.285703e-02
## PC.ae.C36.4_T2 -1.030255e-02 -3.676974e-03 -1.700705e-02
## PC.ae.C36.5_T2 -9.716728e-04 1.608204e-02 4.298450e-02
## PC.ae.C38.0_T2 4.557854e-03 4.822692e-03 3.055495e-02
## PC.ae.C38.2_T2 -2.270883e-02 -1.671835e-02 4.339225e-02
## PC.ae.C38.3_T2 -4.194058e-02 -1.818879e-03 2.162365e-02
## PC.ae.C38.4_T2 -1.852100e-02 -3.937558e-03 2.499104e-02
## PC.ae.C38.5_T2 -1.271872e-02 4.574518e-02 1.570241e-02
## PC.ae.C38.6_T2 -2.393509e-03 -3.867801e-03 6.281870e-02
## PC.ae.C40.1_T2 -9.441027e-03 5.623426e-04 3.741672e-02
## PC.ae.C40.2_T2 1.248168e-03 7.854576e-03 -1.681343e-03
## PC.ae.C40.3_T2 -3.007910e-02 -1.364593e-02 5.940931e-02
## PC.ae.C40.4_T2 -2.032547e-02 -8.558034e-03 -6.715043e-02
## PC.ae.C40.5_T2 -2.500938e-02 -9.480185e-03 2.630184e-02
## PC.ae.C40.6_T2 9.056461e-03 -4.348990e-03 4.889974e-02
## PC.ae.C42.1_T2 -8.996672e-03 9.354325e-04 3.430023e-02
## PC.ae.C42.2_T2 -5.717372e-03 -5.771262e-03 1.812621e-02
## PC.ae.C42.3_T2 -3.194656e-03 -3.787553e-05 -6.742196e-02
## PC.ae.C42.4_T2 -5.676582e-03 -1.066225e-02 1.352830e-02
## PC.ae.C42.5_T2 -1.633710e-02 -1.151189e-02 1.034898e-02
## PC.ae.C44.3_T2 -2.378579e-02 -4.125315e-03 5.509272e-02
## PC.ae.C44.4_T2 -3.568277e-05 -7.554961e-03 1.608434e-02
## PC.ae.C44.5_T2 1.343282e-02 7.668739e-03 -1.671505e-02
## PC.ae.C44.6_T2 -7.658264e-06 -1.787181e-03 3.142630e-02
## SM..OH..C14.1_T2 1.445243e-02 3.236652e-03 -3.312035e-02
## SM..OH..C16.1_T2 3.365645e-03 4.237589e-03 -7.235356e-02
## SM..OH..C22.1_T2 5.482839e-03 -3.315232e-02 3.322581e-03
## SM..OH..C22.2_T2 2.837897e-02 -7.525910e-03 -1.591190e-02
## SM..OH..C24.1_T2 1.460332e-03 -4.834443e-03 -5.393775e-02
## SM.C16.0_T2 -6.032987e-02 -8.018584e-02 8.611628e-03
## SM.C16.1_T2 4.293658e-03 -2.687482e-02 -1.165035e-02
## SM.C18.0_T2 -5.275215e-02 3.266988e-02 -3.587488e-02
## SM.C18.1_T2 2.131152e-02 2.143218e-02 4.293345e-02
## SM.C20.2_T2 9.469069e-04 -8.112077e-04 7.247939e-02
## SM.C24.0_T2 -5.331266e-02 -6.183288e-02 -5.288761e-02
## SM.C24.1_T2 -2.060196e-02 -5.659446e-02 -6.190337e-03
## MEDDM_T4 3.541201e-03 -7.548380e-03 5.220239e-02
## MEDCOL_T4 -1.860532e-02 4.673959e-03 -9.355955e-02
## MEDINF_T4 -2.068164e-02 -5.221715e-04 3.083247e-02
## MEDHTA_T4 -1.225068e-02 1.448771e-02 8.627476e-03
## GLU_T4 -1.863282e-02 1.228925e-02 -4.454295e-03
## INS_T4 -1.071371e-01 1.272969e-01 -3.324858e-02
## HOMA_T4 -3.336362e-02 3.964981e-02 -2.398558e-02
## HBA1C_T4 -1.104605e-02 -1.348865e-02 8.296842e-02
## HBA1C.mmol.mol_T4 -4.626263e-02 -5.563341e-02 -3.783545e-04
## PESO_T4 3.533363e-02 -1.512258e-02 -8.297972e-03
## bmi_T4 3.098577e-02 3.071008e-02 -7.695899e-04
## CC_T4 5.776426e-04 -4.679184e-05 6.441805e-02
## CINT_T4 1.800351e-03 -5.544338e-02 -2.455013e-05
## CAD_T4 -1.600823e-02 1.474144e-03 1.153800e-02
## TAD_T4 -1.703987e-02 8.092855e-02 4.271181e-03
## TAS_T4 4.910076e-02 1.993989e-02 2.685433e-03
## TG_T4 8.167765e-03 1.227116e-02 -6.398831e-03
## COL_T4 4.513533e-02 3.798645e-03 -1.960690e-03
## LDL_T4 5.884380e-02 4.036369e-02 1.287144e-02
## HDL_T4 1.427129e-02 -8.743709e-02 6.176977e-03
## VLDL_T4 2.658765e-02 -5.384980e-02 -2.849029e-03
## PCR_T4 -5.558094e-02 8.473924e-02 5.638109e-02
## LEP_T4 -6.790747e-02 7.964019e-02 3.888201e-03
## ADIPO_T4 5.080642e-02 6.030809e-02 -3.658212e-02
## GOT_T4 3.338537e-02 -3.755571e-02 -5.796492e-04
## GPT_T4 2.536972e-02 1.097926e-01 -1.288439e-02
## GGT_T4 -5.799580e-02 6.377419e-02 -8.853067e-03
## URICO_T4 5.049829e-02 -2.761375e-03 -7.712959e-02
## CREAT_T4 1.698526e-02 -8.069392e-03 8.323277e-02
## UREA_T4 5.623567e-02 -8.984320e-03 -8.188091e-03
## HIERRO_T4 3.748530e-02 -3.841517e-02 2.996718e-03
## TRANSF_T4 4.274531e-02 -6.259713e-02 2.604370e-02
## FERR_T4 -2.479804e-02 1.005537e-02 1.687305e-02
## Ile_T4 -4.936390e-02 -3.575053e-02 6.796585e-03
## Leu_T4 -2.644718e-02 9.943449e-03 1.819621e-02
## Val_T4 -9.890216e-04 2.520751e-03 8.585385e-03
## Ala_T4 -5.500822e-02 -4.890537e-02 -5.497377e-03
## Pro_T4 5.079687e-02 4.990576e-02 1.847718e-02
## Gly_T4 8.057911e-02 -1.508693e-02 4.261088e-03
## Ser_T4 2.312225e-02 -3.726208e-02 -1.167936e-02
## Trp_T4 6.088201e-02 -2.332481e-02 1.925184e-03
## Phe_T4 1.020903e-02 3.294650e-02 -9.790934e-03
## Met_T4 1.827218e-02 5.153875e-03 -1.381989e-02
## Orn_T4 7.407911e-02 7.061721e-02 3.301975e-03
## Arg_T4 -3.254947e-02 -2.405612e-02 -8.754819e-03
## His_T4 1.858451e-02 8.532966e-03 -1.053812e-03
## Asn_T4 1.567921e-02 -3.704667e-02 -2.724477e-03
## Asp_T4 1.795619e-01 -6.283104e-02 3.010575e-03
## Glu_T4 -3.730497e-02 1.876912e-02 4.904714e-03
## Gln_T4 4.200471e-02 3.432836e-02 -3.113812e-04
## Cit_T4 7.553356e-02 5.891736e-03 1.976573e-03
## Tyr_T4 3.433599e-02 2.658149e-02 9.625836e-03
## Thr_T4 7.262812e-02 -7.527740e-02 1.174837e-02
## Lys_T4 2.165776e-02 1.695061e-02 -2.768542e-02
## Creatinine_T4 -2.779948e-03 -4.922814e-02 -6.823370e-03
## Kynurenine_T4 1.721296e-02 -1.172129e-01 -2.066939e-02
## Putrescine_T4 -3.587727e-02 2.796932e-02 -6.187393e-03
## Sarcosine_T4 8.030274e-02 3.455674e-02 7.832482e-03
## Serotonin_T4 -3.388582e-02 2.974088e-02 -6.891250e-03
## Taurine_T4 2.623844e-02 -4.701784e-02 9.123169e-03
## SDMA_T4 2.295269e-03 -4.370276e-03 6.662936e-02
## C0_T4 3.400223e-02 -3.899137e-02 5.009364e-03
## C2_T4 2.222563e-02 -2.574409e-02 3.447928e-02
## C3.OH_T4 4.816187e-03 3.260458e-03 5.013776e-02
## C6..C4.1.DC._T4 -4.391274e-02 -3.319275e-02 -6.991741e-03
## C5.DC..C6.OH._T4 1.550392e-02 -2.805756e-02 3.828026e-02
## C7.DC_T4 1.217091e-01 9.607679e-04 2.437349e-02
## C8_T4 3.519273e-03 -4.371217e-03 5.044278e-02
## C10_T4 1.297557e-03 -1.822612e-02 -6.798629e-03
## C10.1_T4 3.640459e-03 -3.928930e-03 -8.338528e-02
## C10.2_T4 3.037224e-03 -6.228832e-04 -1.008726e-02
## C14.1_T4 -9.808122e-05 -3.787365e-03 4.467123e-02
## C14.2_T4 -6.169711e-04 -2.561592e-03 -1.594554e-02
## C16.1_T4 2.447486e-02 -6.667934e-03 -4.399771e-02
## C16.2_T4 9.466180e-05 -1.980437e-03 4.605233e-03
## C16.2.OH_T4 2.531286e-02 -6.052545e-03 1.783496e-02
## C18.1_T4 -1.185532e-03 -3.546594e-03 4.738480e-02
## C18.1.OH_T4 1.354866e-03 -1.963221e-03 3.694975e-02
## C18.2_T4 -3.070343e-04 -2.076472e-03 -6.933576e-02
## lysoPC.a.C16.0_T4 -8.960688e-02 -3.130023e-02 1.753058e-02
## lysoPC.a.C16.1_T4 -5.560283e-02 1.490320e-02 4.911563e-02
## lysoPC.a.C17.0_T4 -1.179195e-02 2.248875e-03 -9.194845e-02
## lysoPC.a.C18.0_T4 -4.714478e-02 -4.680706e-02 1.056323e-02
## lysoPC.a.C18.1_T4 -5.669431e-02 -5.632950e-02 6.874862e-03
## lysoPC.a.C18.2_T4 -1.448296e-02 -8.277863e-02 1.452448e-02
## lysoPC.a.C20.3_T4 -1.400773e-02 -3.002468e-02 -7.443948e-02
## lysoPC.a.C20.4_T4 6.344671e-03 -1.796050e-02 7.658959e-03
## lysoPC.a.C24.0_T4 -5.356445e-04 3.634277e-03 -1.402007e-02
## lysoPC.a.C26.0_T4 -6.238993e-02 3.214101e-02 -1.999433e-02
## lysoPC.a.C26.1_T4 3.759218e-04 1.112320e-02 8.053970e-02
## lysoPC.a.C28.0_T4 -5.590914e-02 3.905935e-02 2.970499e-02
## lysoPC.a.C28.1_T4 1.224045e-03 7.215176e-03 3.887105e-02
## PC.aa.C24.0_T4 -4.145083e-03 2.459448e-01 6.987118e-03
## PC.aa.C28.1_T4 -5.360296e-04 2.017126e-02 -1.880529e-02
## PC.aa.C30.0_T4 -1.619341e-03 1.100443e-03 6.352610e-02
## PC.aa.C32.0_T4 -1.926690e-02 -2.022390e-02 -1.084107e-02
## PC.aa.C32.1_T4 -7.812108e-02 -4.428512e-02 1.904516e-02
## PC.aa.C32.3_T4 1.880629e-03 -6.574085e-04 -3.876031e-04
## PC.aa.C34.1_T4 -6.707279e-02 -1.640968e-02 -2.801755e-03
## PC.aa.C34.2_T4 -2.706243e-03 4.920455e-04 1.386172e-02
## PC.aa.C34.3_T4 -2.359548e-02 -1.675165e-02 -5.330119e-02
## PC.aa.C34.4_T4 2.502746e-03 -1.743923e-03 -5.287389e-03
## PC.aa.C36.0_T4 1.297474e-03 -2.655497e-02 4.523997e-02
## PC.aa.C36.1_T4 -3.077571e-02 8.609085e-03 3.718572e-02
## PC.aa.C36.2_T4 1.280266e-02 4.924081e-03 1.587826e-02
## PC.aa.C36.3_T4 -3.148612e-02 2.217078e-02 1.009993e-02
## PC.aa.C36.4_T4 2.719424e-02 4.958850e-02 -5.790704e-03
## PC.aa.C36.5_T4 3.298694e-03 1.003592e-02 5.192476e-03
## PC.aa.C38.0_T4 -3.572701e-03 -7.179518e-03 2.232846e-02
## PC.aa.C38.1_T4 1.713964e-02 -9.513107e-04 4.219611e-02
## PC.aa.C38.3_T4 -4.147320e-02 4.188911e-03 1.039604e-03
## PC.aa.C38.4_T4 3.182560e-02 5.823958e-02 1.315510e-02
## PC.aa.C38.5_T4 -5.532962e-02 1.427337e-02 -8.158666e-03
## PC.aa.C38.6_T4 -1.579986e-02 -1.663049e-02 -1.110512e-02
## PC.aa.C40.1_T4 -1.441520e-02 6.013732e-02 -4.036861e-03
## PC.aa.C40.2_T4 -6.841671e-03 3.642220e-03 -9.138817e-02
## PC.aa.C40.3_T4 -6.427382e-03 5.787821e-03 -3.140695e-02
## PC.aa.C40.4_T4 -3.037147e-02 7.677125e-03 4.649973e-02
## PC.aa.C40.5_T4 -6.474920e-02 -7.241818e-03 -1.199201e-02
## PC.aa.C40.6_T4 5.569195e-03 7.885848e-03 -1.084821e-03
## PC.aa.C42.0_T4 4.508229e-04 -5.331988e-05 -5.832180e-02
## PC.aa.C42.1_T4 -2.713788e-03 -4.278105e-03 3.932888e-02
## PC.aa.C42.2_T4 -1.665557e-03 -1.982422e-03 5.752484e-02
## PC.aa.C42.4_T4 -2.352722e-03 7.166621e-04 -5.318721e-02
## PC.aa.C42.5_T4 -5.792581e-04 1.183763e-04 6.545374e-03
## PC.aa.C42.6_T4 -6.889339e-02 -7.229025e-03 -2.549314e-02
## PC.ae.C30.0_T4 -5.351146e-02 2.606355e-02 3.114139e-02
## PC.ae.C32.1_T4 3.000401e-03 -2.245929e-02 8.214277e-02
## PC.ae.C32.2_T4 2.836318e-03 -8.452436e-04 2.929758e-02
## PC.ae.C34.0_T4 4.951641e-03 5.871521e-03 7.638271e-02
## PC.ae.C34.1_T4 -4.612759e-03 -1.459644e-02 -3.439298e-02
## PC.ae.C34.2_T4 2.265143e-02 1.537843e-02 -4.212153e-02
## PC.ae.C34.3_T4 7.519439e-03 -4.607384e-02 -5.229349e-02
## PC.ae.C36.0_T4 2.825495e-03 9.785216e-05 1.383733e-02
## PC.ae.C36.1_T4 -2.490455e-02 1.072065e-02 4.450703e-02
## PC.ae.C36.2_T4 2.693491e-02 2.998863e-02 -3.274973e-02
## PC.ae.C36.3_T4 7.183942e-03 1.170317e-02 -4.091323e-02
## PC.ae.C36.4_T4 -1.070167e-02 1.280544e-02 1.385070e-02
## PC.ae.C36.5_T4 1.964429e-02 -3.959434e-03 -6.019295e-02
## PC.ae.C38.0_T4 -6.896057e-03 -1.534156e-03 2.946692e-02
## PC.ae.C38.2_T4 -1.735111e-02 -7.607331e-03 3.038591e-02
## PC.ae.C38.3_T4 -1.699409e-02 6.688576e-03 -2.892272e-02
## PC.ae.C38.4_T4 2.954729e-02 2.231272e-02 3.468280e-02
## PC.ae.C38.5_T4 -6.448546e-03 2.579717e-02 -4.795265e-02
## PC.ae.C38.6_T4 1.913924e-03 2.072852e-02 6.447955e-02
## PC.ae.C40.1_T4 1.089495e-03 4.911733e-03 -8.162156e-02
## PC.ae.C40.2_T4 7.518083e-03 1.361354e-02 -3.705033e-02
## PC.ae.C40.3_T4 -1.041887e-02 2.388737e-03 5.896205e-02
## PC.ae.C40.4_T4 -1.882456e-03 9.731180e-03 -5.065285e-02
## PC.ae.C40.5_T4 -1.717635e-02 8.625078e-03 5.159758e-02
## PC.ae.C40.6_T4 3.770378e-03 -2.786326e-03 -8.823197e-02
## PC.ae.C42.1_T4 -6.142455e-03 -2.191074e-03 -2.138451e-02
## PC.ae.C42.2_T4 -7.627588e-03 3.756545e-04 -6.684848e-02
## PC.ae.C42.3_T4 -8.059620e-03 -3.842776e-03 -7.228746e-02
## PC.ae.C42.4_T4 -9.260045e-04 1.677662e-03 4.009022e-02
## PC.ae.C42.5_T4 -1.546865e-02 1.030788e-02 -5.391245e-02
## PC.ae.C44.3_T4 -1.002413e-04 -1.119134e-03 -4.566008e-02
## PC.ae.C44.4_T4 -1.178238e-03 -2.284230e-03 4.268307e-02
## PC.ae.C44.5_T4 -2.156955e-04 2.263205e-02 -7.925856e-02
## PC.ae.C44.6_T4 -1.049783e-03 1.083071e-03 8.453695e-03
## SM..OH..C14.1_T4 1.167771e-02 1.907123e-02 3.213269e-02
## SM..OH..C16.1_T4 8.344522e-03 1.253076e-03 -7.172978e-02
## SM..OH..C22.1_T4 2.297454e-02 1.149490e-02 3.079210e-02
## SM..OH..C22.2_T4 4.790855e-03 -7.214427e-03 -2.332117e-02
## SM..OH..C24.1_T4 -2.204073e-03 -3.331860e-03 -2.995442e-02
## SM.C16.0_T4 -3.629509e-02 -1.174250e-02 2.656754e-03
## SM.C16.1_T4 -2.045717e-02 -5.967919e-02 -8.954089e-03
## SM.C18.0_T4 -4.971794e-02 2.908138e-03 -2.636626e-03
## SM.C18.1_T4 -3.384185e-02 -4.320896e-02 -6.258848e-02
## SM.C20.2_T4 3.175940e-03 -9.998631e-04 3.420525e-03
## SM.C24.0_T4 -6.337337e-02 1.277187e-03 -6.819404e-02
## SM.C24.1_T4 -3.170051e-02 1.746461e-02 -3.934003e-03
## MEDDM_T5 -1.355341e-02 1.065473e-02 -1.856397e-03
## MEDCOL_T5 -1.355341e-02 1.065473e-02 -1.856397e-03
## MEDINF_T5 -3.345322e-02 9.419170e-03 6.979941e-02
## MEDHTA_T5 -1.164352e-02 4.741425e-03 -2.631707e-03
## GLU_T5 -5.735239e-02 3.918977e-02 1.692142e-03
## INS_T5 -1.084779e-03 -2.275484e-02 2.764159e-02
## HOMA_T5 -5.606631e-03 -9.078356e-03 -3.662978e-02
## HBA1C_T5 -7.477921e-03 3.337715e-03 1.113166e-01
## HBA1C.mmol.mol_T5 -3.450463e-02 1.399929e-03 -3.700645e-03
## PESO_T5 -1.160869e-02 2.357410e-02 -1.912528e-02
## bmi_T5 2.681734e-02 5.686409e-02 -4.008682e-04
## CC_T5 -2.313234e-04 -2.536317e-03 -9.411360e-02
## CINT_T5 -9.632960e-03 -1.595070e-02 1.938235e-02
## CAD_T5 2.496270e-02 2.643972e-02 -4.359005e-03
## TAD_T5 -9.626002e-02 -1.992305e-02 1.770690e-02
## TAS_T5 -4.958430e-02 2.855518e-03 -3.022694e-03
## TG_T5 -6.476389e-02 2.050843e-02 -1.410450e-02
## COL_T5 -5.198300e-02 -1.261013e-03 1.105661e-02
## LDL_T5 -9.605562e-02 -1.725291e-02 1.475917e-02
## HDL_T5 8.441686e-02 1.351849e-02 1.472178e-02
## VLDL_T5 4.349399e-02 -9.288720e-03 8.405263e-03
## PCR_T5 -6.989847e-02 6.588722e-03 5.109754e-02
## LEP_T5 -3.754050e-03 -2.313493e-02 -4.191885e-03
## ADIPO_T5 7.431132e-02 6.167638e-03 -2.135666e-02
## GOT_T5 1.175744e-02 -1.337260e-01 -8.053676e-03
## GPT_T5 -4.085770e-02 -7.531909e-03 -6.924883e-03
## GGT_T5 -2.795291e-02 -2.007005e-02 6.859558e-03
## URICO_T5 2.858849e-02 -5.738664e-03 -6.599193e-02
## CREAT_T5 2.855504e-03 -1.362841e-03 -6.764623e-04
## UREA_T5 -7.433651e-02 2.754515e-02 1.653994e-03
## HIERRO_T5 2.011792e-02 -2.532321e-02 -1.831837e-02
## TRANSF_T5 -3.471343e-02 -4.245654e-02 -3.027793e-02
## FERR_T5 2.830419e-02 1.056411e-02 -6.064023e-03
## Ile_T5 1.209890e-03 2.255629e-02 -1.762195e-02
## Leu_T5 3.154459e-02 5.447706e-02 -2.810685e-02
## Val_T5 3.074485e-02 6.251918e-02 -2.359785e-02
## Ala_T5 -2.948820e-02 -4.069985e-02 -1.977880e-04
## Pro_T5 2.412245e-02 -1.789637e-02 2.581798e-02
## Gly_T5 4.595468e-02 2.487049e-02 1.443400e-03
## Ser_T5 -5.594041e-02 -1.162319e-01 1.029631e-02
## Trp_T5 -7.724231e-03 3.058947e-02 -9.586423e-03
## Phe_T5 2.333795e-03 -1.433547e-02 -8.448475e-03
## Met_T5 4.189847e-03 -2.108631e-02 -1.334497e-02
## Orn_T5 8.866049e-02 -2.431777e-02 8.231751e-03
## Arg_T5 -7.977362e-02 6.180142e-03 -4.439346e-03
## His_T5 3.506819e-02 1.406799e-02 -1.243201e-02
## Asn_T5 -3.106037e-02 -9.255531e-02 1.249375e-03
## Asp_T5 -9.350662e-03 -1.659064e-02 7.789327e-03
## Glu_T5 9.057909e-03 1.520514e-02 1.068449e-02
## Gln_T5 -2.700433e-02 -5.631390e-02 -1.607484e-02
## Cit_T5 8.875381e-02 8.469419e-02 -1.316876e-02
## Tyr_T5 -2.859062e-02 -2.719041e-02 1.101594e-02
## Thr_T5 1.355772e-02 3.115909e-02 8.355677e-03
## Lys_T5 -1.725057e-03 7.545279e-02 -1.622664e-02
## Creatinine_T5 -3.811462e-02 -6.552830e-04 -5.675477e-03
## Kynurenine_T5 -5.630624e-03 -9.908932e-03 5.133936e-03
## Putrescine_T5 -2.512079e-02 -5.637051e-02 -7.545421e-04
## Sarcosine_T5 -5.636116e-02 -8.964666e-03 5.645416e-02
## Serotonin_T5 1.852217e-04 4.454626e-02 -1.057668e-02
## Taurine_T5 3.690367e-02 3.622172e-02 2.530137e-02
## SDMA_T5 3.800387e-03 -2.313339e-04 -4.692322e-02
## C0_T5 1.098738e-02 4.042561e-02 3.039335e-03
## C2_T5 -3.617009e-03 6.983443e-02 2.891759e-02
## C3.OH_T5 2.103310e-04 -7.996348e-04 6.593871e-02
## C6..C4.1.DC._T5 -5.379892e-02 2.856922e-02 -1.283106e-02
## C5.DC..C6.OH._T5 3.749286e-03 2.262026e-02 4.537416e-02
## C7.DC_T5 7.599385e-03 2.180520e-02 -9.640438e-04
## C8_T5 -5.454730e-04 5.484725e-04 -8.220196e-02
## C10_T5 1.906253e-04 2.807676e-04 7.915053e-02
## C10.1_T5 2.499350e-02 2.103898e-02 2.290239e-02
## C10.2_T5 1.988807e-03 -1.107701e-03 6.610145e-02
## C14.1_T5 1.313815e-03 -3.011631e-04 4.569542e-02
## C14.2_T5 2.504843e-03 -9.013067e-04 -1.814535e-02
## C16.1_T5 1.246863e-03 -9.844696e-04 -7.363480e-02
## C16.2_T5 2.100491e-03 -1.396385e-03 -5.612325e-02
## C16.2.OH_T5 -1.160820e-02 -5.760919e-02 3.406411e-02
## C18.1_T5 1.793672e-03 -1.827356e-03 7.063543e-02
## C18.1.OH_T5 1.748040e-03 -1.456364e-03 3.208977e-02
## C18.2_T5 1.415610e-03 -1.370468e-03 2.107264e-02
## lysoPC.a.C16.0_T5 -3.782188e-02 -1.352514e-02 2.366916e-02
## lysoPC.a.C16.1_T5 -3.249100e-02 -1.172365e-02 8.950006e-02
## lysoPC.a.C17.0_T5 5.826640e-03 8.617134e-03 3.935293e-02
## lysoPC.a.C18.0_T5 -3.954753e-02 -1.489427e-02 1.603754e-02
## lysoPC.a.C18.1_T5 -3.419054e-02 -3.678295e-02 3.115680e-03
## lysoPC.a.C18.2_T5 -3.986185e-02 -6.243956e-02 1.516870e-02
## lysoPC.a.C20.3_T5 1.067299e-02 -1.865153e-03 -8.087957e-02
## lysoPC.a.C20.4_T5 2.675864e-02 -2.464119e-02 -1.491142e-02
## lysoPC.a.C24.0_T5 1.743194e-04 6.928899e-04 3.459723e-02
## lysoPC.a.C26.0_T5 -9.197374e-04 2.715170e-03 3.056951e-02
## lysoPC.a.C26.1_T5 6.123316e-03 4.258241e-03 -2.264614e-02
## lysoPC.a.C28.0_T5 1.305923e-02 5.393367e-03 -8.463442e-03
## lysoPC.a.C28.1_T5 4.765891e-03 2.373059e-03 4.321967e-02
## PC.aa.C24.0_T5 -3.914160e-02 -2.519401e-02 2.896171e-02
## PC.aa.C28.1_T5 1.363425e-02 1.601661e-02 4.789620e-02
## PC.aa.C30.0_T5 7.139112e-03 -2.238949e-03 2.776106e-02
## PC.aa.C32.0_T5 3.010192e-02 -8.492821e-03 -2.730169e-03
## PC.aa.C32.1_T5 3.913081e-02 -2.260303e-03 -2.975586e-02
## PC.aa.C32.3_T5 2.808015e-03 8.106794e-05 -5.671490e-02
## PC.aa.C34.1_T5 1.646312e-03 -1.735917e-02 7.594419e-03
## PC.aa.C34.2_T5 5.903053e-03 -7.464588e-03 -5.700431e-04
## PC.aa.C34.3_T5 3.131404e-03 3.177634e-02 -2.423386e-02
## PC.aa.C34.4_T5 5.907215e-03 1.848646e-03 9.254655e-03
## PC.aa.C36.0_T5 -1.279086e-02 2.669540e-03 1.690902e-02
## PC.aa.C36.1_T5 -2.884510e-02 -1.314773e-02 -9.956478e-03
## PC.aa.C36.2_T5 -1.360047e-02 -1.112680e-02 5.702019e-03
## PC.aa.C36.3_T5 5.311960e-03 2.776806e-02 1.355275e-02
## PC.aa.C36.4_T5 5.782222e-02 1.066611e-02 2.012432e-02
## PC.aa.C36.5_T5 5.762082e-02 5.299252e-02 6.305850e-02
## PC.aa.C38.0_T5 -2.549500e-02 3.117129e-03 2.588167e-02
## PC.aa.C38.1_T5 -4.446399e-03 1.263475e-02 -5.199548e-02
## PC.aa.C38.3_T5 1.504606e-02 5.750614e-03 -3.254522e-03
## PC.aa.C38.4_T5 5.107536e-02 2.686804e-02 1.522907e-02
## PC.aa.C38.5_T5 1.792111e-02 5.100107e-02 2.963566e-04
## PC.aa.C38.6_T5 -3.855621e-02 3.298310e-02 -5.611348e-03
## PC.aa.C40.1_T5 1.941136e-02 7.775974e-05 -1.375261e-02
## PC.aa.C40.2_T5 -6.621693e-03 8.909918e-04 -4.261965e-02
## PC.aa.C40.3_T5 -3.578622e-03 2.207977e-03 6.294528e-03
## PC.aa.C40.4_T5 -9.535723e-03 2.568050e-03 -6.775539e-02
## PC.aa.C40.5_T5 -5.917441e-03 2.638173e-02 -3.730871e-02
## PC.aa.C40.6_T5 -2.159565e-02 3.688033e-02 -9.858462e-03
## PC.aa.C42.0_T5 -3.914248e-04 -3.461133e-03 4.156091e-02
## PC.aa.C42.1_T5 9.898823e-04 -1.601123e-03 -9.147108e-02
## PC.aa.C42.2_T5 -1.857462e-03 -6.513315e-04 -5.453200e-02
## PC.aa.C42.4_T5 -2.072377e-03 -1.472222e-03 -2.550724e-02
## PC.aa.C42.5_T5 1.612050e-03 -6.558268e-04 3.684300e-02
## PC.aa.C42.6_T5 -3.560559e-02 -2.444479e-02 5.494055e-02
## PC.ae.C30.0_T5 -1.725777e-02 -5.426048e-03 6.953575e-02
## PC.ae.C32.1_T5 8.500126e-03 -6.392108e-03 -6.656511e-02
## PC.ae.C32.2_T5 2.200527e-03 7.038120e-05 -1.549870e-02
## PC.ae.C34.0_T5 3.949858e-03 -2.644535e-03 4.533234e-03
## PC.ae.C34.1_T5 6.353584e-03 9.820413e-03 -5.550650e-04
## PC.ae.C34.2_T5 3.332195e-03 2.577345e-02 -5.008930e-03
## PC.ae.C34.3_T5 -1.275685e-02 -3.747289e-03 -2.856195e-02
## PC.ae.C36.0_T5 -3.400683e-03 -2.617800e-03 -5.315497e-02
## PC.ae.C36.1_T5 -1.828426e-02 8.805671e-03 -4.859012e-02
## PC.ae.C36.2_T5 1.340806e-02 2.216055e-02 5.390534e-02
## PC.ae.C36.3_T5 -2.701725e-03 1.710938e-02 8.981970e-03
## PC.ae.C36.4_T5 9.404803e-03 4.741814e-03 -2.063785e-02
## PC.ae.C36.5_T5 8.655186e-03 -7.132377e-03 -4.209059e-02
## PC.ae.C38.0_T5 -2.615771e-04 7.355251e-03 -4.071678e-02
## PC.ae.C38.2_T5 -1.536740e-02 1.052793e-02 -4.215303e-02
## PC.ae.C38.3_T5 1.380575e-03 1.162971e-02 -3.851715e-02
## PC.ae.C38.4_T5 2.258673e-02 1.264488e-02 -7.885753e-02
## PC.ae.C38.5_T5 -1.090380e-02 4.542478e-03 2.532075e-02
## PC.ae.C38.6_T5 -5.986093e-03 1.592318e-02 -4.694887e-03
## PC.ae.C40.1_T5 -8.836806e-03 1.433661e-03 -4.314543e-02
## PC.ae.C40.2_T5 -1.311426e-03 7.418267e-03 -8.725087e-02
## PC.ae.C40.3_T5 -6.951987e-03 2.466045e-03 5.589785e-02
## PC.ae.C40.4_T5 2.929965e-03 8.602193e-04 6.773652e-02
## PC.ae.C40.5_T5 -1.165546e-02 -1.341571e-03 -8.808593e-02
## PC.ae.C40.6_T5 -2.992650e-03 1.195146e-02 6.129472e-02
## PC.ae.C42.1_T5 -1.237884e-03 1.404401e-03 -1.168013e-02
## PC.ae.C42.2_T5 -3.618661e-03 2.300888e-03 -2.342941e-02
## PC.ae.C42.3_T5 -2.828074e-03 2.512145e-03 8.762658e-02
## PC.ae.C42.4_T5 5.500987e-03 1.799558e-03 -9.088007e-03
## PC.ae.C42.5_T5 9.395476e-04 -1.657487e-02 -4.251347e-02
## PC.ae.C44.3_T5 -3.845465e-04 -6.335177e-04 7.074290e-02
## PC.ae.C44.4_T5 3.830698e-05 -1.014468e-03 3.222213e-02
## PC.ae.C44.5_T5 1.661112e-02 1.792846e-03 -5.465262e-02
## PC.ae.C44.6_T5 1.804555e-02 -4.371308e-03 1.979390e-02
## SM..OH..C14.1_T5 2.992407e-03 3.117966e-02 -9.774168e-03
## SM..OH..C16.1_T5 6.404140e-03 7.955493e-03 -9.158340e-02
## SM..OH..C22.1_T5 7.688167e-03 3.093015e-02 3.970707e-03
## SM..OH..C22.2_T5 1.723052e-02 4.043607e-02 9.087486e-02
## SM..OH..C24.1_T5 6.480023e-03 3.595573e-03 -5.531856e-03
## SM.C16.0_T5 -7.941236e-03 4.357139e-02 9.050542e-03
## SM.C16.1_T5 -3.979627e-02 3.931582e-02 3.244983e-02
## SM.C18.0_T5 -4.862009e-02 -2.398544e-02 1.224432e-02
## SM.C18.1_T5 -3.089381e-02 -2.235646e-02 -2.918205e-02
## SM.C20.2_T5 4.011518e-03 4.858889e-04 4.032779e-04
## SM.C24.0_T5 1.628254e-02 3.878261e-02 -2.254805e-02
## SM.C24.1_T5 2.209519e-02 4.338080e-02 4.856202e-04summary(PCAseMA)## Importance of components:
## PC1 PC2 PC3 PC4 PC5 PC6 PC7
## Standard deviation 18.9326 7.37793 5.80678 5.36651 5.21288 4.42129 4.03210
## Proportion of Variance 0.5233 0.07947 0.04922 0.04204 0.03967 0.02854 0.02373
## Cumulative Proportion 0.5233 0.60274 0.65196 0.69401 0.73368 0.76221 0.78595
## PC8 PC9 PC10 PC11 PC12 PC13 PC14
## Standard deviation 3.61080 3.46476 2.99399 2.90510 2.84023 2.67100 2.63356
## Proportion of Variance 0.01903 0.01752 0.01309 0.01232 0.01178 0.01041 0.01013
## Cumulative Proportion 0.80498 0.82251 0.83559 0.84791 0.85969 0.87010 0.88023
## PC15 PC16 PC17 PC18 PC19 PC20 PC21
## Standard deviation 2.59189 2.5504 2.43882 2.28260 2.22287 2.11893 2.06772
## Proportion of Variance 0.00981 0.0095 0.00868 0.00761 0.00721 0.00655 0.00624
## Cumulative Proportion 0.89004 0.8995 0.90821 0.91582 0.92303 0.92959 0.93583
## PC22 PC23 PC24 PC25 PC26 PC27 PC28
## Standard deviation 2.04296 1.98508 1.88904 1.85318 1.80243 1.75920 1.7352
## Proportion of Variance 0.00609 0.00575 0.00521 0.00501 0.00474 0.00452 0.0044
## Cumulative Proportion 0.94192 0.94768 0.95289 0.95790 0.96264 0.96716 0.9716
## PC29 PC30 PC31 PC32 PC33 PC34 PC35
## Standard deviation 1.71137 1.62451 1.53198 1.49427 1.38232 1.37421 1.32833
## Proportion of Variance 0.00428 0.00385 0.00343 0.00326 0.00279 0.00276 0.00258
## Cumulative Proportion 0.97583 0.97968 0.98311 0.98637 0.98916 0.99192 0.99449
## PC36 PC37 PC38 PC39
## Standard deviation 1.22484 1.1091 1.02129 1.161e-14
## Proportion of Variance 0.00219 0.0018 0.00152 0.000e+00
## Cumulative Proportion 0.99668 0.9985 1.00000 1.000e+00L’anàlisi no és molt concloent. Per obtenir un 70% de la variancia ens calen 5 components, el que és molt. Entenc que hi ha massa variables en joc i segurament caldria reduir abans d’alguna altra manera. Segurament hi ha explicacions biològiques que estaria bé aplicar, però a mi se m’escapen ja que no comprenc totes les variables.
# carreguem les dades pel gràfic
loads <- round(PCAseMA$sdev^2/sum(PCAseMA$sdev^2)*100,1)
groupColors <- c(rep("red", 4), rep("blue", 4))
xlab <- c(paste("PC1",loads[1],"%"))
ylab <- c(paste("PC2",loads[2],"%"))
# grafiquem
plot(PCAseMA$x[,1:2],
xlab=xlab,
ylab=ylab,
pch = c(3,21),
col=c("blue","red"),
main ="Principal components (PCA)",
ylim=c(-20,30))
names <- rownames(PCAseMA$x)
text(PCAseMA$x[,1],PCAseMA$x[,2],names, pos=3, cex=.6)
Lo unic destacable que s’aprecia és que la mostra 37 està a molta distància de la resta
library(plotly)## Warning: package 'plotly' was built under R version 4.4.3## Loading required package: ggplot2##
## Attaching package: 'plotly'## The following object is masked from 'package:ggplot2':
##
## last_plot## The following object is masked from 'package:IRanges':
##
## slice## The following object is masked from 'package:S4Vectors':
##
## rename## The following object is masked from 'package:stats':
##
## filter## The following object is masked from 'package:graphics':
##
## layoutfig <- plot_ly(as.data.frame(assay(seMAnormalized)),
x = ~PCAseMA$x[,1], y = ~PCAseMA$x[,2], z = ~PCAseMA$x[,3]) %>%
add_markers(marker = list(size = 3)) %>%
layout(scene = list(xaxis = list(title = "PC1"),
yaxis = list(title = "PC2"),
zaxis = list(title = "PC3")))
figAra ja són 3 els casos que se separen força de la resta
7. Cerca de patrons
Ho farem amb un heatmap de la matriu de correlacions que permetria veure totes les relacions
cor_matrix <- cor(na.omit(assay(seMAnormalized)))
heatmap(cor_matrix)
Es veuen dos grups de variables més correlacionades, però en general les correlacions són debils.
Ara fem un altre heatmap que calcula distancies entre les variables i les mostres
dist_matrix <- t(assay(seMAnormalized))
heatmap(dist_matrix, col=heat.colors(16))
Hi ha tantes mostres i variables que no es poden veure be totes les relacions, però sembla que hi ha un patró clar de proximitat en les primeres variables del gràfic i algunes que estan a molta distància cap a baix. Pel que fa a les mostres, la 37 es mostra clarament diferent a la resta com ja s’havia vist a la PCA